ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.31199890
2	cellular ketone body metabolic process (GO:0046950)	4.65693720
3	behavioral response to nicotine (GO:0035095)	4.33919262
4	ketone body metabolic process (GO:1902224)	4.22852560
5	protein polyglutamylation (GO:0018095)	4.04265759
6	somite development (GO:0061053)	3.81537718
7	regulation of cilium movement (GO:0003352)	3.75891373
8	platelet dense granule organization (GO:0060155)	3.74676612
9	DNA deamination (GO:0045006)	3.68258125
10	indolalkylamine metabolic process (GO:0006586)	3.61407444
11	L-fucose catabolic process (GO:0042355)	3.60846245
12	fucose catabolic process (GO:0019317)	3.60846245
13	L-fucose metabolic process (GO:0042354)	3.60846245
14	acrosome reaction (GO:0007340)	3.50417838
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.47938350
16	detection of light stimulus involved in visual perception (GO:0050908)	3.47938350
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46426366
18	NADH dehydrogenase complex assembly (GO:0010257)	3.46426366
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46426366
20	neural tube formation (GO:0001841)	3.44458595
21	multicellular organism reproduction (GO:0032504)	3.39881424
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39831240
23	protein complex biogenesis (GO:0070271)	3.39418149
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.37723053
25	limb bud formation (GO:0060174)	3.34011828
26	piRNA metabolic process (GO:0034587)	3.32654602
27	sperm motility (GO:0030317)	3.30993574
28	cullin deneddylation (GO:0010388)	3.27315917
29	protein deneddylation (GO:0000338)	3.23643992
30	DNA double-strand break processing (GO:0000729)	3.20068120
31	kynurenine metabolic process (GO:0070189)	3.20023303
32	axoneme assembly (GO:0035082)	3.16725688
33	cornea development in camera-type eye (GO:0061303)	3.15616199
34	kidney morphogenesis (GO:0060993)	3.14573467
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11867197
36	indole-containing compound catabolic process (GO:0042436)	3.11767504
37	indolalkylamine catabolic process (GO:0046218)	3.11767504
38	tryptophan catabolic process (GO:0006569)	3.11767504
39	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.10009958
40	tryptophan metabolic process (GO:0006568)	3.08438443
41	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03128580
42	regulation of meiosis I (GO:0060631)	3.01341156
43	epithelial cilium movement (GO:0003351)	3.00991033
44	negative regulation of telomere maintenance (GO:0032205)	3.00439695
45	indole-containing compound metabolic process (GO:0042430)	3.00035980
46	replication fork processing (GO:0031297)	2.97084922
47	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.96116033
48	ubiquinone biosynthetic process (GO:0006744)	2.95158328
49	regulation of microtubule-based movement (GO:0060632)	2.93583126
50	pyrimidine nucleobase catabolic process (GO:0006208)	2.91762919
51	spinal cord motor neuron differentiation (GO:0021522)	2.90930767
52	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.90248832
53	primary amino compound metabolic process (GO:1901160)	2.89272977
54	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86963967
55	neuronal action potential (GO:0019228)	2.85285793
56	rhodopsin mediated signaling pathway (GO:0016056)	2.81443822
57	respiratory chain complex IV assembly (GO:0008535)	2.78164112
58	synapsis (GO:0007129)	2.76473470
59	serotonin metabolic process (GO:0042428)	2.73902952
60	ubiquinone metabolic process (GO:0006743)	2.73437087
61	regulation of glucokinase activity (GO:0033131)	2.73247381
62	regulation of hexokinase activity (GO:1903299)	2.73247381
63	regulation of telomere maintenance (GO:0032204)	2.73131899
64	DNA demethylation (GO:0080111)	2.68161718
65	cell wall macromolecule catabolic process (GO:0016998)	2.68066964
66	fusion of sperm to egg plasma membrane (GO:0007342)	2.68020061
67	inositol phosphate catabolic process (GO:0071545)	2.66045146
68	photoreceptor cell maintenance (GO:0045494)	2.65505671
69	recombinational repair (GO:0000725)	2.64767611
70	DNA methylation involved in gamete generation (GO:0043046)	2.64624391
71	xenobiotic catabolic process (GO:0042178)	2.64022004
72	double-strand break repair via homologous recombination (GO:0000724)	2.64018467
73	seminiferous tubule development (GO:0072520)	2.63995552
74	synaptic transmission, cholinergic (GO:0007271)	2.62571202
75	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.62495457
76	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.62495457
77	regulation of translation, ncRNA-mediated (GO:0045974)	2.62495457
78	postsynaptic membrane organization (GO:0001941)	2.62057660
79	retinal cone cell development (GO:0046549)	2.61996125
80	cytochrome complex assembly (GO:0017004)	2.59635534
81	negative regulation of mast cell activation (GO:0033004)	2.59126968
82	mannosylation (GO:0097502)	2.58980337
83	positive regulation of meiosis (GO:0045836)	2.58041136
84	benzene-containing compound metabolic process (GO:0042537)	2.58002319
85	spermatid development (GO:0007286)	2.57434139
86	regulation of mesoderm development (GO:2000380)	2.56830324
87	male meiosis (GO:0007140)	2.55929828
88	regulation of action potential (GO:0098900)	2.55410115
89	dopamine transport (GO:0015872)	2.55273305
90	protein localization to cilium (GO:0061512)	2.54171995
91	axonemal dynein complex assembly (GO:0070286)	2.53807089
92	centriole replication (GO:0007099)	2.52374159
93	proline transport (GO:0015824)	2.52072470
94	sympathetic nervous system development (GO:0048485)	2.51835958
95	nucleobase catabolic process (GO:0046113)	2.51376491
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50543328
97	male meiosis I (GO:0007141)	2.50505171
98	negative regulation of interleukin-1 beta production (GO:0032691)	2.50110011
99	rRNA catabolic process (GO:0016075)	2.49943066
100	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.48729735

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.35459927
2	VDR_22108803_ChIP-Seq_LS180_Human	3.28268070
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.16453636
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.01615024
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.92038866
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.89698861
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55646854
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35492882
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34838598
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30835640
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29888406
12	P300_19829295_ChIP-Seq_ESCs_Human	2.17963346
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16201455
14	FUS_26573619_Chip-Seq_HEK293_Human	2.12298997
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11795757
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03994718
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.94468551
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.94184680
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88848022
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86300083
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81974321
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76226007
23	EWS_26573619_Chip-Seq_HEK293_Human	1.75693503
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67207226
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66894216
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65585575
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64121094
28	AR_25329375_ChIP-Seq_VCAP_Human	1.61783640
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.60807101
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60807101
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59492709
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56092370
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.55774201
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52263873
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51878649
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51861244
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.51586778
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46951418
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46140170
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46140170
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44789428
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44789428
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42054772
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41772249
45	STAT3_23295773_ChIP-Seq_U87_Human	1.40615995
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.40335181
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39379020
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39077911
49	TCF4_23295773_ChIP-Seq_U87_Human	1.39029892
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.38011930
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.38004617
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36945497
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35769865
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35378458
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.35005056
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34755775
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33974555
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33804572
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33053716
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29941563
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28503983
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27373219
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25925698
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25925698
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25901898
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25712415
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24497832
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22599989
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22084786
70	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21328624
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21191729
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20902729
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19307619
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17453565
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15583965
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15550758
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14351109
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13713729
79	NCOR_22424771_ChIP-Seq_293T_Human	1.13314929
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12519321
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10962950
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08358425
83	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08072797
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.06663456
85	AR_20517297_ChIP-Seq_VCAP_Human	1.06080483
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06042604
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03998456
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03432281
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02209150
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00288291
91	CDX2_22108803_ChIP-Seq_LS180_Human	0.99036314
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97877769
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97570840
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96685007
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96587169
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96341620
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95502731
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.94325598
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.94015348
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92512039

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.17714706
2	MP0001968_abnormal_touch/_nociception	3.03166348
3	MP0005410_abnormal_fertilization	2.69685043
4	MP0005551_abnormal_eye_electrophysiolog	2.66964063
5	MP0002736_abnormal_nociception_after	2.61581221
6	MP0003195_calcinosis	2.60319380
7	MP0002102_abnormal_ear_morphology	2.44727363
8	MP0000372_irregular_coat_pigmentation	2.29916663
9	MP0002735_abnormal_chemical_nociception	2.26751966
10	MP0008872_abnormal_physiological_respon	2.24029540
11	MP0004147_increased_porphyrin_level	2.14884089
12	MP0005253_abnormal_eye_physiology	2.09081925
13	MP0006072_abnormal_retinal_apoptosis	2.07720060
14	MP0002234_abnormal_pharynx_morphology	2.01342183
15	MP0005645_abnormal_hypothalamus_physiol	1.99658727
16	MP0006292_abnormal_olfactory_placode	1.87919892
17	MP0002837_dystrophic_cardiac_calcinosis	1.87805576
18	MP0005646_abnormal_pituitary_gland	1.84172748
19	MP0003787_abnormal_imprinting	1.82736384
20	MP0003880_abnormal_central_pattern	1.81386418
21	MP0009745_abnormal_behavioral_response	1.80586083
22	MP0003136_yellow_coat_color	1.77172861
23	MP0003646_muscle_fatigue	1.71251097
24	MP0001501_abnormal_sleep_pattern	1.70975998
25	MP0004043_abnormal_pH_regulation	1.68774396
26	MP0001485_abnormal_pinna_reflex	1.68112825
27	MP0000427_abnormal_hair_cycle	1.64892275
28	MP0002272_abnormal_nervous_system	1.62815146
29	MP0000569_abnormal_digit_pigmentation	1.58453342
30	MP0002938_white_spotting	1.57911342
31	MP0003283_abnormal_digestive_organ	1.57746213
32	MP0009046_muscle_twitch	1.56113028
33	MP0003718_maternal_effect	1.55294661
34	MP0008875_abnormal_xenobiotic_pharmacok	1.53147500
35	MP0002160_abnormal_reproductive_system	1.52311920
36	MP0005174_abnormal_tail_pigmentation	1.51245917
37	MP0002653_abnormal_ependyma_morphology	1.48627556
38	MP0001984_abnormal_olfaction	1.48215546
39	MP0004742_abnormal_vestibular_system	1.42939224
40	MP0002638_abnormal_pupillary_reflex	1.40131217
41	MP0003698_abnormal_male_reproductive	1.39743057
42	MP0005389_reproductive_system_phenotype	1.39715552
43	MP0005367_renal/urinary_system_phenotyp	1.36927971
44	MP0000516_abnormal_urinary_system	1.36927971
45	MP0004133_heterotaxia	1.33968035
46	MP0008995_early_reproductive_senescence	1.33486043
47	MP0001986_abnormal_taste_sensitivity	1.29740485
48	MP0004885_abnormal_endolymph	1.29260784
49	MP0001929_abnormal_gametogenesis	1.28868104
50	MP0002751_abnormal_autonomic_nervous	1.28072038
51	MP0001486_abnormal_startle_reflex	1.27793344
52	MP0001529_abnormal_vocalization	1.23473074
53	MP0002282_abnormal_trachea_morphology	1.23334644
54	MP0003011_delayed_dark_adaptation	1.22785310
55	MP0006276_abnormal_autonomic_nervous	1.19474038
56	MP0004142_abnormal_muscle_tone	1.19274655
57	MP0005171_absent_coat_pigmentation	1.18956697
58	MP0002734_abnormal_mechanical_nocicepti	1.14422878
59	MP0002095_abnormal_skin_pigmentation	1.14098088
60	MP0001970_abnormal_pain_threshold	1.12160881
61	MP0005167_abnormal_blood-brain_barrier	1.11560848
62	MP0000383_abnormal_hair_follicle	1.10115472
63	MP0000631_abnormal_neuroendocrine_gland	1.07059361
64	MP0002572_abnormal_emotion/affect_behav	1.06673879
65	MP0002733_abnormal_thermal_nociception	1.06664950
66	MP0002064_seizures	1.06133276
67	MP0002067_abnormal_sensory_capabilities	1.04882001
68	MP0005084_abnormal_gallbladder_morpholo	1.04477811
69	MP0001905_abnormal_dopamine_level	1.03457073
70	MP0003950_abnormal_plasma_membrane	1.02405816
71	MP0003137_abnormal_impulse_conducting	1.00980658
72	MP0002876_abnormal_thyroid_physiology	1.00251952
73	MP0010386_abnormal_urinary_bladder	0.99644302
74	MP0008789_abnormal_olfactory_epithelium	0.99569185
75	MP0005386_behavior/neurological_phenoty	0.98389161
76	MP0004924_abnormal_behavior	0.98389161
77	MP0003119_abnormal_digestive_system	0.98344329
78	MP0005195_abnormal_posterior_eye	0.97995008
79	MP0002557_abnormal_social/conspecific_i	0.96743721
80	MP0000538_abnormal_urinary_bladder	0.96707513
81	MP0002210_abnormal_sex_determination	0.96623550
82	MP0009697_abnormal_copulation	0.93243668
83	MP0005377_hearing/vestibular/ear_phenot	0.91361542
84	MP0003878_abnormal_ear_physiology	0.91361542
85	MP0005379_endocrine/exocrine_gland_phen	0.90986832
86	MP0008058_abnormal_DNA_repair	0.90930858
87	MP0003635_abnormal_synaptic_transmissio	0.89078716
88	MP0001919_abnormal_reproductive_system	0.87828373
89	MP0005391_vision/eye_phenotype	0.87384007
90	MP0000647_abnormal_sebaceous_gland	0.87285894
91	MP0000230_abnormal_systemic_arterial	0.87277312
92	MP0000653_abnormal_sex_gland	0.86260855
93	MP0002752_abnormal_somatic_nervous	0.85261752
94	MP0002928_abnormal_bile_duct	0.81268492
95	MP0002277_abnormal_respiratory_mucosa	0.80422059
96	MP0005075_abnormal_melanosome_morpholog	0.79387352
97	MP0002229_neurodegeneration	0.79310786
98	MP0001145_abnormal_male_reproductive	0.78740988
99	MP0005395_other_phenotype	0.78434246
100	MP0002909_abnormal_adrenal_gland	0.77463008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.93059306
2	Abnormality of midbrain morphology (HP:0002418)	3.91367390
3	Molar tooth sign on MRI (HP:0002419)	3.91367390
4	Pancreatic cysts (HP:0001737)	3.87281262
5	Congenital stationary night blindness (HP:0007642)	3.86214699
6	Birth length less than 3rd percentile (HP:0003561)	3.57009502
7	Nephronophthisis (HP:0000090)	3.54628455
8	Pancreatic fibrosis (HP:0100732)	3.40403788
9	Attenuation of retinal blood vessels (HP:0007843)	3.37784814
10	Type II lissencephaly (HP:0007260)	3.27788408
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.26528572
12	Absent/shortened dynein arms (HP:0200106)	3.26528572
13	Abnormality of the renal medulla (HP:0100957)	3.16019249
14	Abnormality of the renal cortex (HP:0011035)	2.92653369
15	Hyperventilation (HP:0002883)	2.80595205
16	Chronic hepatic failure (HP:0100626)	2.77847103
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.75060184
18	Pendular nystagmus (HP:0012043)	2.63439154
19	Chorioretinal atrophy (HP:0000533)	2.62814035
20	Focal motor seizures (HP:0011153)	2.59896322
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.59391115
22	Abnormal respiratory epithelium morphology (HP:0012253)	2.59391115
23	Abnormality of the labia minora (HP:0012880)	2.57234770
24	Abnormality of alanine metabolism (HP:0010916)	2.56548968
25	Hyperalaninemia (HP:0003348)	2.56548968
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.56548968
27	Intestinal atresia (HP:0011100)	2.52086108
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.44830299
29	Congenital, generalized hypertrichosis (HP:0004540)	2.44202487
30	Decreased central vision (HP:0007663)	2.41296466
31	Abnormal ciliary motility (HP:0012262)	2.39847057
32	Abolished electroretinogram (ERG) (HP:0000550)	2.38799671
33	Inability to walk (HP:0002540)	2.33685033
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.33072101
35	Patellar aplasia (HP:0006443)	2.31556930
36	Increased corneal curvature (HP:0100692)	2.31344098
37	Keratoconus (HP:0000563)	2.31344098
38	Renal cortical cysts (HP:0000803)	2.28487806
39	Abnormality of macular pigmentation (HP:0008002)	2.25638428
40	Medial flaring of the eyebrow (HP:0010747)	2.24930398
41	Sclerocornea (HP:0000647)	2.21709781
42	Cystic liver disease (HP:0006706)	2.20119770
43	Cerebellar dysplasia (HP:0007033)	2.17232146
44	Polydipsia (HP:0001959)	2.17184854
45	Abnormal drinking behavior (HP:0030082)	2.17184854
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.13795980
47	Lissencephaly (HP:0001339)	2.13005743
48	Methylmalonic acidemia (HP:0002912)	2.12504676
49	Progressive inability to walk (HP:0002505)	2.12301298
50	Large for gestational age (HP:0001520)	2.11195501
51	Mitochondrial inheritance (HP:0001427)	2.10968942
52	Tubular atrophy (HP:0000092)	2.10171795
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09712799
54	Increased CSF lactate (HP:0002490)	2.07741326
55	Hypothermia (HP:0002045)	2.06969032
56	Acute necrotizing encephalopathy (HP:0006965)	2.06657715
57	Furrowed tongue (HP:0000221)	2.05871912
58	Male pseudohermaphroditism (HP:0000037)	2.05560044
59	Optic nerve hypoplasia (HP:0000609)	2.03058516
60	Anencephaly (HP:0002323)	2.02583988
61	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.02572450
62	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.02013119
63	Optic disc pallor (HP:0000543)	2.01199905
64	Progressive macrocephaly (HP:0004481)	1.98874061
65	Acute encephalopathy (HP:0006846)	1.96318878
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96089942
67	Congenital sensorineural hearing impairment (HP:0008527)	1.94544024
68	Abnormal biliary tract physiology (HP:0012439)	1.94349624
69	Bile duct proliferation (HP:0001408)	1.94349624
70	Hypoplastic ischia (HP:0003175)	1.92731990
71	Hyperglycinuria (HP:0003108)	1.90393977
72	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.89983180
73	Gaze-evoked nystagmus (HP:0000640)	1.89754066
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88944359
75	Severe muscular hypotonia (HP:0006829)	1.84740021
76	Small hand (HP:0200055)	1.84648893
77	Polyuria (HP:0000103)	1.82893918
78	Absent thumb (HP:0009777)	1.81952320
79	Absent speech (HP:0001344)	1.80699699
80	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.80656628
81	Focal seizures (HP:0007359)	1.80564564
82	Hepatocellular necrosis (HP:0001404)	1.78847524
83	Abnormality of the pons (HP:0007361)	1.76915264
84	Bilateral microphthalmos (HP:0007633)	1.74815233
85	Abnormality of the ileum (HP:0001549)	1.74726749
86	Thyroiditis (HP:0100646)	1.74304895
87	Type 2 muscle fiber atrophy (HP:0003554)	1.72327679
88	3-Methylglutaconic aciduria (HP:0003535)	1.72080616
89	Oligodactyly (hands) (HP:0001180)	1.70674284
90	Gait imbalance (HP:0002141)	1.70476849
91	Congenital hepatic fibrosis (HP:0002612)	1.69439554
92	Abnormality of DNA repair (HP:0003254)	1.68385814
93	Depressed nasal tip (HP:0000437)	1.68158826
94	Astigmatism (HP:0000483)	1.67074140
95	Dandy-Walker malformation (HP:0001305)	1.66803149
96	Lipid accumulation in hepatocytes (HP:0006561)	1.66712294
97	Occipital encephalocele (HP:0002085)	1.66322470
98	Postaxial foot polydactyly (HP:0001830)	1.65787420
99	Tubulointerstitial nephritis (HP:0001970)	1.65339176
100	Methylmalonic aciduria (HP:0012120)	1.65066437

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09971663
2	BMPR1B	3.89556369
3	ACVR1B	3.46299678
4	WNK3	3.24366833
5	NUAK1	2.73937585
6	ADRBK2	2.64388945
7	TAOK3	2.56734406
8	MAP4K2	2.52299550
9	ZAK	2.47061465
10	MAPK13	2.28832623
11	INSRR	2.27332073
12	WNK4	2.18805287
13	CASK	2.09272462
14	GRK1	1.86658055
15	DAPK2	1.78814804
16	PNCK	1.69634872
17	OXSR1	1.61913250
18	TGFBR1	1.61882118
19	STK39	1.57482085
20	STK38L	1.55536821
21	MARK1	1.50034375
22	PLK2	1.49979460
23	VRK2	1.47968064
24	PLK4	1.47614949
25	MAP3K4	1.36861373
26	TRIM28	1.33625364
27	VRK1	1.20519641
28	MKNK2	1.20295197
29	TLK1	1.15422857
30	TNIK	1.14790754
31	CAMKK2	1.06130439
32	PINK1	1.04394248
33	ADRBK1	1.04388291
34	DYRK2	1.04027275
35	PLK3	0.97012516
36	TXK	0.96631829
37	BRSK2	0.96443187
38	EPHA3	0.96113452
39	MAPKAPK3	0.91714435
40	MAP2K7	0.89437040
41	PAK3	0.89105757
42	PKN1	0.86151988
43	PDK2	0.84147273
44	PTK2B	0.83587940
45	MUSK	0.82538541
46	ERBB3	0.81159554
47	EPHA4	0.77470691
48	PRKCE	0.71804752
49	FGFR2	0.70596661
50	WEE1	0.67554851
51	CDK3	0.67411825
52	MKNK1	0.67310850
53	PRKCG	0.60359545
54	SIK2	0.59976019
55	MAPKAPK5	0.59664402
56	IKBKB	0.59350988
57	TIE1	0.57750466
58	CSNK1G2	0.57274296
59	CSNK1G1	0.56836935
60	RPS6KA5	0.55247515
61	CAMK2A	0.52784185
62	GRK5	0.52647763
63	CAMK1	0.52427091
64	CSNK1G3	0.48297369
65	STK11	0.47888321
66	PRKCQ	0.47315420
67	EIF2AK3	0.45792290
68	TSSK6	0.44854663
69	BCR	0.44776494
70	FER	0.44735903
71	PLK1	0.44331925
72	TNK2	0.43734202
73	PIK3CA	0.42633611
74	ATR	0.42603967
75	TAF1	0.42530205
76	TRPM7	0.42463299
77	NTRK3	0.41799659
78	MAPK15	0.40409602
79	NLK	0.38629491
80	TEC	0.38123903
81	MAP2K6	0.36604704
82	CSNK1A1L	0.35939956
83	PRKACA	0.35731207
84	NEK2	0.35725360
85	PRKAA2	0.35662136
86	MST4	0.35643735
87	CCNB1	0.35207139
88	IRAK1	0.35084884
89	STK38	0.34925566
90	PHKG2	0.34765630
91	PHKG1	0.34765630
92	MAP2K2	0.34397102
93	CSNK1A1	0.33615571
94	CSNK1D	0.33525760
95	ROCK1	0.32120743
96	PRKCI	0.31793429
97	OBSCN	0.31442526
98	NTRK2	0.29927994
99	MAP2K1	0.29341652
100	PRKCA	0.28061804

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.80511752
2	Phototransduction_Homo sapiens_hsa04744	3.27991427
3	Butanoate metabolism_Homo sapiens_hsa00650	2.88292070
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60858007
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.51042285
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33777033
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20300916
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19208896
9	Protein export_Homo sapiens_hsa03060	2.11492124
10	Homologous recombination_Homo sapiens_hsa03440	2.08761889
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94143505
12	Propanoate metabolism_Homo sapiens_hsa00640	1.91358844
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86230006
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.81124359
15	Caffeine metabolism_Homo sapiens_hsa00232	1.76680588
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.75179592
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72434668
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.70168745
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67156424
20	Parkinsons disease_Homo sapiens_hsa05012	1.65528406
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62397693
22	Nicotine addiction_Homo sapiens_hsa05033	1.61741112
23	RNA polymerase_Homo sapiens_hsa03020	1.60633640
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60142702
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53310650
26	Olfactory transduction_Homo sapiens_hsa04740	1.53100710
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.45300852
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.41127336
29	Basal transcription factors_Homo sapiens_hsa03022	1.40953279
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31451118
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28725631
32	Taste transduction_Homo sapiens_hsa04742	1.27420483
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26062497
34	Proteasome_Homo sapiens_hsa03050	1.23908773
35	Peroxisome_Homo sapiens_hsa04146	1.23411463
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.19211346
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.13479895
38	Huntingtons disease_Homo sapiens_hsa05016	1.11895431
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11483499
40	ABC transporters_Homo sapiens_hsa02010	1.11060150
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.08274406
42	RNA degradation_Homo sapiens_hsa03018	1.06257740
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.04514062
44	Asthma_Homo sapiens_hsa05310	1.02883783
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02048337
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01144198
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99830534
48	Alzheimers disease_Homo sapiens_hsa05010	0.98227550
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97861774
50	Morphine addiction_Homo sapiens_hsa05032	0.95208273
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91323257
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91085927
53	One carbon pool by folate_Homo sapiens_hsa00670	0.88702989
54	Retinol metabolism_Homo sapiens_hsa00830	0.87991185
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86844706
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86699032
57	Fatty acid degradation_Homo sapiens_hsa00071	0.84723967
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80890459
59	Circadian entrainment_Homo sapiens_hsa04713	0.78200587
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.77581765
61	Purine metabolism_Homo sapiens_hsa00230	0.71167673
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70252112
63	Insulin secretion_Homo sapiens_hsa04911	0.69811474
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68622113
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.66727320
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63965483
67	Metabolic pathways_Homo sapiens_hsa01100	0.63414600
68	Regulation of autophagy_Homo sapiens_hsa04140	0.61240944
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.60958795
70	Salivary secretion_Homo sapiens_hsa04970	0.59565786
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58030899
72	Serotonergic synapse_Homo sapiens_hsa04726	0.57874826
73	GABAergic synapse_Homo sapiens_hsa04727	0.56481015
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55781402
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55462924
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55349870
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.54571016
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53268005
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51944043
80	Circadian rhythm_Homo sapiens_hsa04710	0.51439827
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50195718
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49033316
83	Allograft rejection_Homo sapiens_hsa05330	0.49025875
84	Glutathione metabolism_Homo sapiens_hsa00480	0.46600577
85	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44795250
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40654485
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39205061
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39044303
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38635612
90	Histidine metabolism_Homo sapiens_hsa00340	0.38086776
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37137645
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36701707
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36316365
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36128908
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.35833531
96	Base excision repair_Homo sapiens_hsa03410	0.34927343
97	Mineral absorption_Homo sapiens_hsa04978	0.34560410
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.33080809
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33070078
100	Sulfur metabolism_Homo sapiens_hsa00920	0.32418573

NPAP1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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