NPAS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.49008581
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48986425
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.29101468
4regulation of neuronal synaptic plasticity (GO:0048168)5.23361672
5regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.16228491
6regulation of glutamate receptor signaling pathway (GO:1900449)5.11352489
7synaptic vesicle exocytosis (GO:0016079)5.09042685
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98378811
9synaptic vesicle maturation (GO:0016188)4.95942563
10long-term synaptic potentiation (GO:0060291)4.95200542
11glutamate secretion (GO:0014047)4.88916887
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75308958
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.73026597
14positive regulation of synapse maturation (GO:0090129)4.69299558
15glutamate receptor signaling pathway (GO:0007215)4.61205336
16positive regulation of dendritic spine morphogenesis (GO:0061003)4.61154318
17response to corticosterone (GO:0051412)4.59119586
18protein localization to synapse (GO:0035418)4.54020162
19regulation of synaptic vesicle exocytosis (GO:2000300)4.47936295
20neuron recognition (GO:0008038)4.33524450
21serotonin metabolic process (GO:0042428)4.32966121
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22313925
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.14052063
24cerebellar granule cell differentiation (GO:0021707)4.12057060
25regulation of synaptic plasticity (GO:0048167)4.10043913
26locomotory exploration behavior (GO:0035641)4.03717612
27synaptic transmission, glutamatergic (GO:0035249)4.00151163
28response to gravity (GO:0009629)3.99443924
29vocalization behavior (GO:0071625)3.96877228
30response to mineralocorticoid (GO:0051385)3.93468601
31regulation of synaptic vesicle transport (GO:1902803)3.93429808
32positive regulation of membrane potential (GO:0045838)3.93278572
33regulation of inositol phosphate biosynthetic process (GO:0010919)3.92039193
34positive regulation of dendritic spine development (GO:0060999)3.91521726
35behavioral defense response (GO:0002209)3.89006868
36behavioral fear response (GO:0001662)3.89006868
37primary amino compound metabolic process (GO:1901160)3.87614980
38sleep (GO:0030431)3.87118437
39regulation of dendritic spine morphogenesis (GO:0061001)3.86065553
40long term synaptic depression (GO:0060292)3.83893283
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.83737370
42signal complex assembly (GO:0007172)3.81983721
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77984200
44neuron-neuron synaptic transmission (GO:0007270)3.73738525
45neuron cell-cell adhesion (GO:0007158)3.70542694
46fear response (GO:0042596)3.70472993
47exploration behavior (GO:0035640)3.69131260
48neuronal action potential propagation (GO:0019227)3.66019171
49response to pheromone (GO:0019236)3.66018427
50regulation of synapse maturation (GO:0090128)3.65243612
51regulation of synapse structural plasticity (GO:0051823)3.64471644
52axonal fasciculation (GO:0007413)3.62108948
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.57172507
54glycerophospholipid catabolic process (GO:0046475)3.54180677
55regulation of postsynaptic membrane potential (GO:0060078)3.54114452
56negative regulation of dendrite morphogenesis (GO:0050774)3.50504821
57cellular response to gonadotropin stimulus (GO:0071371)3.44797028
58long-term memory (GO:0007616)3.42355512
59neurotransmitter-gated ion channel clustering (GO:0072578)3.40605237
60regulation of glutamate secretion (GO:0014048)3.40577954
61cellular sodium ion homeostasis (GO:0006883)3.39110028
62regulation of dendritic spine development (GO:0060998)3.38166181
63activation of Rac GTPase activity (GO:0032863)3.36105751
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32613680
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.31037978
66alanine transport (GO:0032328)3.30241978
67regulation of vesicle fusion (GO:0031338)3.29986812
68neurotransmitter secretion (GO:0007269)3.29139068
69presynaptic membrane assembly (GO:0097105)3.28844105
70response to histamine (GO:0034776)3.26873228
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26070178
72gamma-aminobutyric acid transport (GO:0015812)3.25085083
73synaptic vesicle endocytosis (GO:0048488)3.24376871
74layer formation in cerebral cortex (GO:0021819)3.21207285
75detection of calcium ion (GO:0005513)3.19984948
76protein localization to cilium (GO:0061512)3.18078242
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17924173
78clathrin coat assembly (GO:0048268)3.17318842
79neurotransmitter transport (GO:0006836)3.17058637
80insulin secretion (GO:0030073)3.15518896
81regulation of sarcomere organization (GO:0060297)3.15285270
82innervation (GO:0060384)3.14635969
83positive regulation of fibroblast migration (GO:0010763)3.14063786
84learning (GO:0007612)3.13908760
85dendrite morphogenesis (GO:0048813)3.13784695
86regulation of glucocorticoid secretion (GO:2000849)3.13689587
87dopamine receptor signaling pathway (GO:0007212)3.12519116
88presynaptic membrane organization (GO:0097090)3.12141324
89adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11775690
90regulation of bile acid biosynthetic process (GO:0070857)3.11509005
91postsynaptic membrane organization (GO:0001941)3.07538967
92response to isoquinoline alkaloid (GO:0014072)3.06140110
93dendritic spine morphogenesis (GO:0060997)3.05809460
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05614829
95chemosensory behavior (GO:0007635)3.05109567
96membrane depolarization (GO:0051899)3.04547531
97dendritic spine organization (GO:0097061)3.02437069
98regulation of calcium ion-dependent exocytosis (GO:0017158)3.00478409
99associative learning (GO:0008306)3.00442331
100positive regulation of synaptic transmission (GO:0050806)2.97940473
101membrane depolarization during action potential (GO:0086010)2.96653740
102cellular response to calcium ion (GO:0071277)2.96361751
103regulation of synaptic transmission (GO:0050804)2.95427810
104response to amphetamine (GO:0001975)2.94667452
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.92584792
106neuromuscular process controlling balance (GO:0050885)2.90971767
107glial cell proliferation (GO:0014009)2.90536372
108synaptic vesicle docking involved in exocytosis (GO:0016081)2.90206951
109regulation of neurotransmitter levels (GO:0001505)2.90002305
110negative regulation of dendrite development (GO:2000171)2.89289499
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88686435
112nucleobase catabolic process (GO:0046113)2.88672664
113negative regulation of amino acid transport (GO:0051956)2.88296626
114relaxation of smooth muscle (GO:0044557)2.87688865
115proline transport (GO:0015824)2.87571899
116cerebellar Purkinje cell layer development (GO:0021680)2.87500590
117learning or memory (GO:0007611)2.86636517
118regulation of neurotransmitter transport (GO:0051588)2.85600718
119negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85470884
120negative regulation of circadian rhythm (GO:0042754)2.84449097
121positive regulation of neurotransmitter transport (GO:0051590)2.83714713
122cellular potassium ion homeostasis (GO:0030007)2.83100174
123dentate gyrus development (GO:0021542)2.82609382
124startle response (GO:0001964)2.81659872
125water-soluble vitamin biosynthetic process (GO:0042364)2.80624752
126positive regulation of meiosis (GO:0045836)2.80367923
127regulation of neurotransmitter uptake (GO:0051580)2.79086026
128response to dietary excess (GO:0002021)2.77656829
129urinary tract smooth muscle contraction (GO:0014848)2.75822646
130negative regulation of neurotransmitter transport (GO:0051589)2.75290604
131glycosphingolipid biosynthetic process (GO:0006688)2.73477498
132synaptic transmission (GO:0007268)2.69884970
133neuron fate determination (GO:0048664)2.69650549
134neuronal ion channel clustering (GO:0045161)2.68627044
135righting reflex (GO:0060013)2.65930523
136regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65438307
137potassium ion transmembrane transport (GO:0071805)2.65283099
138cellular potassium ion transport (GO:0071804)2.65283099
139negative regulation of hormone biosynthetic process (GO:0032353)2.62431441
140macroautophagy (GO:0016236)2.61199295
141calcium ion-dependent exocytosis (GO:0017156)2.60413834
142potassium ion homeostasis (GO:0055075)2.59585442
143signal release (GO:0023061)2.58960555
144positive regulation of meiotic cell cycle (GO:0051446)2.57373464
145indole-containing compound metabolic process (GO:0042430)2.56238885
146calcium ion import (GO:0070509)2.55827388
147regulation of neurotransmitter secretion (GO:0046928)2.55111454
148epithelial cell fate commitment (GO:0072148)2.54386141
149positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52578743
150neurofilament cytoskeleton organization (GO:0060052)2.52368310
151brain morphogenesis (GO:0048854)2.52228881
152response to cocaine (GO:0042220)2.50397049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.54199211
2GBX2_23144817_ChIP-Seq_PC3_Human3.56905965
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25263328
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11218090
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06120714
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89575988
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89575988
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.88560385
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.83921834
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82923782
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.75999138
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.72758384
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66535003
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62313450
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59018462
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58363582
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.48213735
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41664516
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33721507
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27704416
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15857469
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13602568
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11398141
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07964411
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02197486
26IGF1R_20145208_ChIP-Seq_DFB_Human2.00777181
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99154474
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88116060
29AR_21572438_ChIP-Seq_LNCaP_Human1.83870765
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83712839
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78295954
32* DROSHA_22980978_ChIP-Seq_HELA_Human1.77369162
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77149212
34* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73558427
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69568421
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63111007
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57101513
38SMAD4_21799915_ChIP-Seq_A2780_Human1.50146330
39TAF15_26573619_Chip-Seq_HEK293_Human1.44355772
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42067306
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.41938834
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41506910
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40178707
44HTT_18923047_ChIP-ChIP_STHdh_Human1.39451836
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38424437
46FUS_26573619_Chip-Seq_HEK293_Human1.38146137
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36820928
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.36284265
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.32344084
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31667776
51P300_19829295_ChIP-Seq_ESCs_Human1.31492234
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30192334
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30154723
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30154247
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28964216
56TCF4_23295773_ChIP-Seq_U87_Human1.26662353
57AR_25329375_ChIP-Seq_VCAP_Human1.26074593
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24914023
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.24888902
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.22677746
61ZNF274_21170338_ChIP-Seq_K562_Hela1.20319010
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17337304
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16938641
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16757815
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.16739625
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.16481776
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15663771
68VDR_22108803_ChIP-Seq_LS180_Human1.15076959
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14345730
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14143388
71CBP_20019798_ChIP-Seq_JUKART_Human1.14143388
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14014927
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.13504097
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12930931
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.11232632
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11225506
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10012677
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09107979
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07537780
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07100741
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06125362
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05731356
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.05564002
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05556260
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05217922
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.05015911
87STAT3_23295773_ChIP-Seq_U87_Human1.04040715
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.03002661
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02407973
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.02267394
91TP53_18474530_ChIP-ChIP_U2OS_Human1.01357919
92P53_22387025_ChIP-Seq_ESCs_Mouse1.01111480
93AR_19668381_ChIP-Seq_PC3_Human1.01014399
94RNF2_27304074_Chip-Seq_NSC_Mouse1.00440470
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.97755587
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97707148
97* CTCF_27219007_Chip-Seq_Bcells_Human0.97543720
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97417675
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96929179
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94872451
101* PIAS1_25552417_ChIP-Seq_VCAP_Human0.94700336
102TAL1_26923725_Chip-Seq_HPCs_Mouse0.93918930
103TCF4_22108803_ChIP-Seq_LS180_Human0.93688268
104E2F1_18555785_Chip-Seq_ESCs_Mouse0.93288693
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.92572074
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92483376
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.92360789
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91585852
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90258703
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90239049
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.89826375
112KDM2B_26808549_Chip-Seq_K562_Human0.89169460
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87882383
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87720571
115BCAT_22108803_ChIP-Seq_LS180_Human0.87625209
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87545858
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86169897
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84753077
119JUN_21703547_ChIP-Seq_K562_Human0.84173714
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82440249
121AHR_22903824_ChIP-Seq_MCF-7_Human0.82284018
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80981242
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79660304
124RUNX2_22187159_ChIP-Seq_PCA_Human0.79230961
125* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79198118
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78756305
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78221617
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78221617
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77075611
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76221464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.99043240
2MP0003880_abnormal_central_pattern5.72049474
3* MP0003635_abnormal_synaptic_transmissio4.22838162
4MP0001501_abnormal_sleep_pattern3.57391531
5MP0002063_abnormal_learning/memory/cond3.36993830
6MP0002638_abnormal_pupillary_reflex3.26097157
7MP0009745_abnormal_behavioral_response3.13001325
8MP0004270_analgesia2.97302626
9* MP0002064_seizures2.93525754
10* MP0002572_abnormal_emotion/affect_behav2.80263905
11MP0003329_amyloid_beta_deposits2.73594107
12MP0005646_abnormal_pituitary_gland2.65713688
13MP0003122_maternal_imprinting2.52411803
14MP0001968_abnormal_touch/_nociception2.40021232
15MP0002272_abnormal_nervous_system2.38336668
16* MP0009046_muscle_twitch2.28017069
17MP0005423_abnormal_somatic_nervous2.27368520
18MP0001486_abnormal_startle_reflex2.19262960
19MP0001440_abnormal_grooming_behavior2.14775693
20MP0002557_abnormal_social/conspecific_i2.09967029
21MP0002736_abnormal_nociception_after1.99540237
22MP0003787_abnormal_imprinting1.94876204
23MP0002735_abnormal_chemical_nociception1.85828402
24MP0002822_catalepsy1.82806197
25MP0010368_abnormal_lymphatic_system1.77620562
26MP0005645_abnormal_hypothalamus_physiol1.72569673
27MP0000778_abnormal_nervous_system1.70326075
28MP0003890_abnormal_embryonic-extraembry1.66663896
29MP0002734_abnormal_mechanical_nocicepti1.64496075
30MP0002067_abnormal_sensory_capabilities1.63183071
31MP0006276_abnormal_autonomic_nervous1.62832421
32MP0008569_lethality_at_weaning1.62689608
33MP0003195_calcinosis1.62204471
34MP0005379_endocrine/exocrine_gland_phen1.61293418
35MP0002184_abnormal_innervation1.58905413
36* MP0005386_behavior/neurological_phenoty1.58675184
37* MP0004924_abnormal_behavior1.58675184
38MP0002733_abnormal_thermal_nociception1.57886900
39MP0002909_abnormal_adrenal_gland1.56978854
40MP0001905_abnormal_dopamine_level1.54134469
41MP0006072_abnormal_retinal_apoptosis1.53142126
42MP0000604_amyloidosis1.49460878
43* MP0004811_abnormal_neuron_physiology1.44551169
44MP0001944_abnormal_pancreas_morphology1.43193289
45MP0009780_abnormal_chondrocyte_physiolo1.43111380
46MP0003075_altered_response_to1.42456002
47MP0002163_abnormal_gland_morphology1.41652935
48MP0001970_abnormal_pain_threshold1.39744986
49MP0003123_paternal_imprinting1.36795354
50MP0001502_abnormal_circadian_rhythm1.32797024
51MP0001984_abnormal_olfaction1.28348133
52MP0002693_abnormal_pancreas_physiology1.27793074
53MP0004858_abnormal_nervous_system1.27770787
54MP0002102_abnormal_ear_morphology1.26969927
55* MP0002066_abnormal_motor_capabilities/c1.25340613
56* MP0002882_abnormal_neuron_morphology1.23568841
57MP0004133_heterotaxia1.19614911
58MP0000955_abnormal_spinal_cord1.16795702
59MP0004142_abnormal_muscle_tone1.15915545
60MP0006292_abnormal_olfactory_placode1.12994571
61MP0003690_abnormal_glial_cell1.12919047
62MP0003172_abnormal_lysosome_physiology1.11792164
63MP0001188_hyperpigmentation1.08993528
64MP0003879_abnormal_hair_cell1.07308571
65MP0010234_abnormal_vibrissa_follicle1.05964480
66MP0010329_abnormal_lipoprotein_level1.05946849
67MP0003631_nervous_system_phenotype1.03572088
68MP0003633_abnormal_nervous_system1.03058196
69MP0002152_abnormal_brain_morphology1.00506799
70MP0000631_abnormal_neuroendocrine_gland1.00145676
71MP0003183_abnormal_peptide_metabolism0.99764851
72MP0003121_genomic_imprinting0.98482205
73MP0002090_abnormal_vision0.97498940
74MP0002069_abnormal_eating/drinking_beha0.97012464
75MP0000569_abnormal_digit_pigmentation0.96291270
76MP0003632_abnormal_nervous_system0.96260516
77MP0002234_abnormal_pharynx_morphology0.95355998
78MP0005595_abnormal_vascular_smooth0.94623042
79MP0005187_abnormal_penis_morphology0.92698240
80MP0008995_early_reproductive_senescence0.91085642
81MP0005623_abnormal_meninges_morphology0.91002671
82MP0005551_abnormal_eye_electrophysiolog0.90874043
83MP0002078_abnormal_glucose_homeostasis0.90498449
84MP0008872_abnormal_physiological_respon0.87798445
85MP0002254_reproductive_system_inflammat0.87422461
86MP0005409_darkened_coat_color0.85987843
87MP0000751_myopathy0.85566085
88MP0001346_abnormal_lacrimal_gland0.84601114
89MP0001485_abnormal_pinna_reflex0.81210178
90MP0001963_abnormal_hearing_physiology0.81162668
91MP0004885_abnormal_endolymph0.79330764
92* MP0003634_abnormal_glial_cell0.77227073
93MP0002876_abnormal_thyroid_physiology0.76304964
94MP0004145_abnormal_muscle_electrophysio0.74588501
95MP0003119_abnormal_digestive_system0.74464812
96MP0004085_abnormal_heartbeat0.74349683
97MP0004510_myositis0.74056201
98MP0003303_peritoneal_inflammation0.73559714
99MP0003137_abnormal_impulse_conducting0.73013040
100MP0008961_abnormal_basal_metabolism0.72928402
101MP0003953_abnormal_hormone_level0.72141240
102MP0005448_abnormal_energy_balance0.71968354
103MP0001765_abnormal_ion_homeostasis0.71691054
104MP0000920_abnormal_myelination0.71159250
105MP0000013_abnormal_adipose_tissue0.71156538
106MP0001529_abnormal_vocalization0.70039110
107MP0002837_dystrophic_cardiac_calcinosis0.68560933
108* MP0002229_neurodegeneration0.67293115
109MP0010386_abnormal_urinary_bladder0.66952085
110MP0008874_decreased_physiological_sensi0.66840056
111MP0000639_abnormal_adrenal_gland0.66266245
112MP0001756_abnormal_urination0.66040807
113MP0002752_abnormal_somatic_nervous0.63865145
114MP0005084_abnormal_gallbladder_morpholo0.62498778
115MP0008877_abnormal_DNA_methylation0.60866101
116MP0001664_abnormal_digestion0.60149726
117MP0002653_abnormal_ependyma_morphology0.58220817
118MP0003283_abnormal_digestive_organ0.57204323
119MP0005394_taste/olfaction_phenotype0.57097639
120MP0005499_abnormal_olfactory_system0.57097639
121MP0004742_abnormal_vestibular_system0.56061252
122MP0004147_increased_porphyrin_level0.54754032
123MP0001177_atelectasis0.52730385
124MP0005535_abnormal_body_temperature0.51880489
125MP0005253_abnormal_eye_physiology0.51505834
126MP0010770_preweaning_lethality0.49277075

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.53613931
2Focal seizures (HP:0007359)5.45482560
3Myokymia (HP:0002411)5.41892321
4Limb dystonia (HP:0002451)5.36770086
5Visual hallucinations (HP:0002367)5.14722775
6Decreased circulating renin level (HP:0003351)5.07073771
7Epileptic encephalopathy (HP:0200134)4.66963073
8Increased circulating renin level (HP:0000848)4.44242256
9Abnormality of the lower motor neuron (HP:0002366)4.11899961
10Growth hormone excess (HP:0000845)4.03358981
11Hyperactive renin-angiotensin system (HP:0000841)4.00601592
12Atonic seizures (HP:0010819)3.84771509
13Supranuclear gaze palsy (HP:0000605)3.66229300
14Absence seizures (HP:0002121)3.37469477
15Dialeptic seizures (HP:0011146)3.31193223
16Action tremor (HP:0002345)3.24868032
17Anxiety (HP:0000739)3.22143716
18Cerebral inclusion bodies (HP:0100314)3.16344016
19Hyperventilation (HP:0002883)3.11848905
20Hypothermia (HP:0002045)3.11612732
21Abnormal eating behavior (HP:0100738)3.11126973
22Hypoglycemic coma (HP:0001325)3.03066289
23Generalized tonic-clonic seizures (HP:0002069)3.02501526
24Depression (HP:0000716)3.00776668
25Hypoglycemic seizures (HP:0002173)2.90834555
26Epileptiform EEG discharges (HP:0011182)2.88952989
27Febrile seizures (HP:0002373)2.88134580
28Agitation (HP:0000713)2.84074823
29Progressive cerebellar ataxia (HP:0002073)2.79913463
30Excessive salivation (HP:0003781)2.79124303
31Drooling (HP:0002307)2.79124303
32EEG with generalized epileptiform discharges (HP:0011198)2.77432057
33Hyperkalemia (HP:0002153)2.76753272
34Poor eye contact (HP:0000817)2.75208759
35Impaired vibration sensation in the lower limbs (HP:0002166)2.71191791
36Hyperinsulinemic hypoglycemia (HP:0000825)2.70864997
37Broad-based gait (HP:0002136)2.70147371
38Hypsarrhythmia (HP:0002521)2.69710248
39Papilledema (HP:0001085)2.67093175
40Large for gestational age (HP:0001520)2.66764334
41Neurofibrillary tangles (HP:0002185)2.64919244
42Medial flaring of the eyebrow (HP:0010747)2.64090471
43Attenuation of retinal blood vessels (HP:0007843)2.55238045
44Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.52360881
45Abnormality of the labia minora (HP:0012880)2.50448055
46Hypomagnesemia (HP:0002917)2.48897313
47Rapidly progressive (HP:0003678)2.46231307
48Abnormal social behavior (HP:0012433)2.46191144
49Impaired social interactions (HP:0000735)2.46191144
50Toxemia of pregnancy (HP:0100603)2.43546731
51Poor suck (HP:0002033)2.43452702
52Ketoacidosis (HP:0001993)2.42351161
53Delusions (HP:0000746)2.42235324
54Truncal ataxia (HP:0002078)2.41849491
55Genetic anticipation (HP:0003743)2.41691117
56Abnormality of renin-angiotensin system (HP:0000847)2.41576202
57Split foot (HP:0001839)2.40971761
58Thickened helices (HP:0000391)2.38626531
59Hyperaldosteronism (HP:0000859)2.38505576
60Bony spicule pigmentary retinopathy (HP:0007737)2.38146528
61Focal dystonia (HP:0004373)2.37528169
62Amblyopia (HP:0000646)2.36085132
63Failure to thrive in infancy (HP:0001531)2.35600770
64Congenital primary aphakia (HP:0007707)2.35296742
65Muscular hypotonia of the trunk (HP:0008936)2.34425737
66Dysmetria (HP:0001310)2.33023320
67Abnormal rod and cone electroretinograms (HP:0008323)2.29737611
68Ankle clonus (HP:0011448)2.27046093
69Polyphagia (HP:0002591)2.25644140
70Hemiparesis (HP:0001269)2.24866557
71Akinesia (HP:0002304)2.23810384
72Absent speech (HP:0001344)2.22917426
73Apathy (HP:0000741)2.22598454
74Anteriorly placed anus (HP:0001545)2.21001719
75Prominent supraorbital ridges (HP:0000336)2.20516214
76Narrow nasal bridge (HP:0000446)2.19306390
77Megalencephaly (HP:0001355)2.14554896
78Abnormality of calcium-phosphate metabolism (HP:0100530)2.13747306
79Generalized myoclonic seizures (HP:0002123)2.13382610
80Gaze-evoked nystagmus (HP:0000640)2.12473234
81Sleep apnea (HP:0010535)2.11924193
82Abnormality of the corticospinal tract (HP:0002492)2.10826445
83Hypoventilation (HP:0002791)2.09842873
84Spastic gait (HP:0002064)2.09835874
85Unilateral renal agenesis (HP:0000122)2.09378788
86Esotropia (HP:0000565)2.06805726
87Mildly elevated creatine phosphokinase (HP:0008180)2.05923554
88Blue irides (HP:0000635)2.05860596
89Hyperthyroidism (HP:0000836)2.05026053
90Mesangial abnormality (HP:0001966)2.03564278
91Type II lissencephaly (HP:0007260)2.03163122
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02639379
93Progressive inability to walk (HP:0002505)2.01618070
94Cerebral hypomyelination (HP:0006808)2.01587156
95Aplasia/hypoplasia of the uterus (HP:0008684)2.00394805
96Spastic tetraplegia (HP:0002510)1.99424364
97Peripheral hypomyelination (HP:0007182)1.98843324
98Lissencephaly (HP:0001339)1.98448268
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.98371553
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98371553
101Long palpebral fissure (HP:0000637)1.98245352
102Intention tremor (HP:0002080)1.98232183
103Double outlet right ventricle (HP:0001719)1.97921032
104Congenital malformation of the right heart (HP:0011723)1.97921032
105Bone cyst (HP:0012062)1.96989757
106Nephronophthisis (HP:0000090)1.96901012
107Severe muscular hypotonia (HP:0006829)1.95175833
108Stereotypic behavior (HP:0000733)1.93223130
109Abnormality of magnesium homeostasis (HP:0004921)1.92843895
110Urinary bladder sphincter dysfunction (HP:0002839)1.92302468
111Open mouth (HP:0000194)1.92221121
112Enlarged penis (HP:0000040)1.91840808
113Psychosis (HP:0000709)1.91660269
114Status epilepticus (HP:0002133)1.90780213
115Dysdiadochokinesis (HP:0002075)1.90332406
116Late onset (HP:0003584)1.88692426
117Obstructive sleep apnea (HP:0002870)1.88246233
118Tented upper lip vermilion (HP:0010804)1.88231035
119Craniofacial dystonia (HP:0012179)1.87224117
120Abnormality of salivation (HP:0100755)1.87030846
121Lower limb asymmetry (HP:0100559)1.86883288
122Bowel incontinence (HP:0002607)1.85578382
123Oligodactyly (hands) (HP:0001180)1.85450083
124Insidious onset (HP:0003587)1.84666290
125Termporal pattern (HP:0011008)1.84666290
126Diminished motivation (HP:0000745)1.83699530
127Type I diabetes mellitus (HP:0100651)1.83680971
128Hammertoe (HP:0001765)1.83372402
129Gait imbalance (HP:0002141)1.83358687
130Choroideremia (HP:0001139)1.82772246
131Symptomatic seizures (HP:0011145)1.82389297
132Large hands (HP:0001176)1.81307502
133Conjugated hyperbilirubinemia (HP:0002908)1.81027324
134Hyperglycemia (HP:0003074)1.80273039
135Polydipsia (HP:0001959)1.80092824
136Abnormal drinking behavior (HP:0030082)1.80092824
137Abnormality of binocular vision (HP:0011514)1.79825435
138Diplopia (HP:0000651)1.79825435
139Bradykinesia (HP:0002067)1.79275121
140Nephrogenic diabetes insipidus (HP:0009806)1.78861681
141Postural tremor (HP:0002174)1.77803914
142Unsteady gait (HP:0002317)1.77555342
143Torticollis (HP:0000473)1.77445474
144Genital tract atresia (HP:0001827)1.76256117
145Specific learning disability (HP:0001328)1.76098978
146Impaired smooth pursuit (HP:0007772)1.75981895
147Diastasis recti (HP:0001540)1.75718761
148Abnormality of vitamin B metabolism (HP:0004340)1.71593862
149Sensorimotor neuropathy (HP:0007141)1.70256271
150Intestinal atresia (HP:0011100)1.68627009
151Volvulus (HP:0002580)1.68566342
152Hyperphosphatemia (HP:0002905)1.66536081
153Limb hypertonia (HP:0002509)1.65528056
154Insulin-resistant diabetes mellitus (HP:0000831)1.65332427
155Widely spaced teeth (HP:0000687)1.65019986
156Decreased muscle mass (HP:0003199)1.64993467
157Vaginal atresia (HP:0000148)1.64093463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.03662842
2EPHA44.91175472
3ARAF3.72199741
4MAP3K93.68449826
5FRK3.53331165
6MAPK153.22188855
7MUSK3.21600743
8KSR22.92913303
9FES2.90178472
10TNIK2.79771109
11MAP2K22.40164589
12PTK2B2.26902689
13MAP3K132.21756429
14NTRK22.19819180
15FER2.02731777
16CSNK1G32.02576417
17PAK61.97871044
18MINK11.92655729
19KSR11.89476948
20RAF11.77099671
21ADRBK21.73976900
22CSNK1G11.68191394
23DAPK21.63136970
24MARK11.61678100
25FGFR21.58872141
26CASK1.54873794
27RIPK41.43787556
28MAP3K21.40708978
29MAPK71.40111842
30RPS6KA21.39301082
31INSRR1.37048497
32ERBB31.36053497
33WNK31.35263084
34MAP4K21.34074116
35TESK11.28186930
36CDK51.22477510
37PAK31.19343433
38UHMK11.14733945
39PLK21.12682693
40CAMK2B1.12009769
41MAP2K71.10318478
42DYRK21.08325919
43MAP3K41.07809398
44STK111.06670886
45CAMK2A1.04945345
46CAMK11.04916695
47SGK21.01906918
48DAPK11.01039678
49GRK50.99028573
50BRAF0.98095308
51TAOK10.96753906
52LIMK10.94373080
53STK38L0.92557047
54PRPF4B0.91867998
55MAP3K10.90719536
56CAMK1G0.84989315
57PRKAA10.84817495
58PRKCG0.84554479
59CCNB10.78941136
60MAPK130.76911695
61MAP2K10.76553285
62GRK10.75578075
63MAP3K110.74648586
64NTRK10.73987940
65MAP2K60.73978154
66CAMK2D0.71868521
67WNK40.71161322
68RPS6KL10.70747526
69RPS6KC10.70747526
70SIK20.69707665
71CDK140.65267240
72CSNK1D0.64195889
73STK160.61023731
74CSNK1E0.61019859
75CDK180.60856010
76BMPR1B0.59835608
77CDK150.59291133
78MOS0.59114177
79MAPK100.57087816
80PRKD30.57013026
81CAMKK10.56500348
82CSNK1A10.56485384
83MARK20.54965751
84AKT30.54466275
85CAMK2G0.54389872
86IRAK20.54118140
87FGR0.53276411
88DMPK0.53169658
89MAP2K40.53088902
90RPS6KA60.52415553
91BMPR20.51523364
92CDK190.51109660
93VRK10.50854427
94PINK10.50759556
95PNCK0.49659122
96MAPK40.49396127
97CDK11A0.47879718
98CSNK1G20.47764440
99PRKCE0.47391915
100PRKACA0.47046426
101TYRO30.45873827
102PHKG20.44753691
103PHKG10.44753691
104DYRK1A0.43755679
105OXSR10.43577822
106SGK30.43022818
107LMTK20.42377884
108FYN0.40903898
109RPS6KA30.40865166
110PAK20.39990824
111ADRBK10.39386761
112PRKCH0.38924698
113PDK10.38438999
114PDPK10.36788405
115NME10.35656573
116CAMK40.34992136
117ICK0.34701332
118STK380.34564530
119ZAK0.34356879
120SGK10.34227349
121TRPM70.33981052
122MAPK80.33579120
123GRK60.33077378
124RPS6KB10.32648592
125PRKCA0.32524375
126GSK3B0.32428394
127PRKD10.32121155
128LATS20.30008321
129SGK2230.29969680
130SGK4940.29969680
131CSNK1A1L0.29658737
132GRK70.29218331
133PRKCZ0.29070747
134HCK0.27990645
135PRKG10.27330311
136MAP3K120.27321487
137STK240.27169843
138PRKD20.27118742
139PRKACB0.26157493

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65194622
2Amphetamine addiction_Homo sapiens_hsa050313.27294638
3Circadian entrainment_Homo sapiens_hsa047133.15532044
4Synaptic vesicle cycle_Homo sapiens_hsa047213.10925871
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.85823117
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75334367
7Circadian rhythm_Homo sapiens_hsa047102.72164102
8Olfactory transduction_Homo sapiens_hsa047402.70945498
9Long-term potentiation_Homo sapiens_hsa047202.64974629
10GABAergic synapse_Homo sapiens_hsa047272.61297349
11Cocaine addiction_Homo sapiens_hsa050302.36738684
12Dopaminergic synapse_Homo sapiens_hsa047282.28735940
13Glutamatergic synapse_Homo sapiens_hsa047242.28547736
14Morphine addiction_Homo sapiens_hsa050322.25472352
15Insulin secretion_Homo sapiens_hsa049112.00253827
16Oxytocin signaling pathway_Homo sapiens_hsa049211.97455952
17Cholinergic synapse_Homo sapiens_hsa047251.96271502
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94324399
19Long-term depression_Homo sapiens_hsa047301.89458884
20Salivary secretion_Homo sapiens_hsa049701.87639745
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86576398
22Taste transduction_Homo sapiens_hsa047421.71328671
23Serotonergic synapse_Homo sapiens_hsa047261.68262282
24Collecting duct acid secretion_Homo sapiens_hsa049661.67141318
25GnRH signaling pathway_Homo sapiens_hsa049121.66161904
26Butanoate metabolism_Homo sapiens_hsa006501.62301276
27Estrogen signaling pathway_Homo sapiens_hsa049151.62228015
28Protein export_Homo sapiens_hsa030601.59619924
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56448771
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56399723
31Gastric acid secretion_Homo sapiens_hsa049711.54835108
32Renin secretion_Homo sapiens_hsa049241.54215133
33Vitamin B6 metabolism_Homo sapiens_hsa007501.50692943
34Prion diseases_Homo sapiens_hsa050201.38315857
35Calcium signaling pathway_Homo sapiens_hsa040201.37866819
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35979115
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.33847699
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31778591
39Regulation of autophagy_Homo sapiens_hsa041401.27473471
40Gap junction_Homo sapiens_hsa045401.26716530
41Vibrio cholerae infection_Homo sapiens_hsa051101.26429468
42cAMP signaling pathway_Homo sapiens_hsa040241.23169800
43Dorso-ventral axis formation_Homo sapiens_hsa043201.12532808
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12130004
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10108970
46Choline metabolism in cancer_Homo sapiens_hsa052311.07576020
47Type II diabetes mellitus_Homo sapiens_hsa049301.05692840
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05677294
49Axon guidance_Homo sapiens_hsa043601.03940357
50Glioma_Homo sapiens_hsa052140.99785284
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96893045
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93016415
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92109356
54Melanogenesis_Homo sapiens_hsa049160.89164279
55Rheumatoid arthritis_Homo sapiens_hsa053230.88859644
56ErbB signaling pathway_Homo sapiens_hsa040120.88239586
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86854397
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.86414036
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.85019371
60Cardiac muscle contraction_Homo sapiens_hsa042600.84213264
61MAPK signaling pathway_Homo sapiens_hsa040100.82594639
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82541065
63Nitrogen metabolism_Homo sapiens_hsa009100.79802058
64Ether lipid metabolism_Homo sapiens_hsa005650.78911658
65Selenocompound metabolism_Homo sapiens_hsa004500.77088543
66Folate biosynthesis_Homo sapiens_hsa007900.76597482
67Parkinsons disease_Homo sapiens_hsa050120.75716447
68Colorectal cancer_Homo sapiens_hsa052100.72092674
69Sphingolipid metabolism_Homo sapiens_hsa006000.68683530
70Tryptophan metabolism_Homo sapiens_hsa003800.65936585
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65522000
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65506536
73Dilated cardiomyopathy_Homo sapiens_hsa054140.65464171
74Mineral absorption_Homo sapiens_hsa049780.64014539
75Thyroid hormone synthesis_Homo sapiens_hsa049180.63805528
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63737228
77Glucagon signaling pathway_Homo sapiens_hsa049220.62277735
78Pancreatic secretion_Homo sapiens_hsa049720.62248213
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60805489
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60773313
81Sulfur metabolism_Homo sapiens_hsa009200.60118707
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59567105
83beta-Alanine metabolism_Homo sapiens_hsa004100.57252307
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57054307
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.56391719
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55796863
87Alcoholism_Homo sapiens_hsa050340.54923101
88VEGF signaling pathway_Homo sapiens_hsa043700.54764130
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.53733469
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52495263
91Renal cell carcinoma_Homo sapiens_hsa052110.52234560
92B cell receptor signaling pathway_Homo sapiens_hsa046620.52170981
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50959106
94Alzheimers disease_Homo sapiens_hsa050100.50649150
95Linoleic acid metabolism_Homo sapiens_hsa005910.50415235
96Oocyte meiosis_Homo sapiens_hsa041140.48318237
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46960368
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46363133
99Phototransduction_Homo sapiens_hsa047440.45434297
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45028467
101Ras signaling pathway_Homo sapiens_hsa040140.44616068
102T cell receptor signaling pathway_Homo sapiens_hsa046600.42839712
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41784486
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41675088
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39341090
106Endometrial cancer_Homo sapiens_hsa052130.39070710
107Prolactin signaling pathway_Homo sapiens_hsa049170.39054401
108African trypanosomiasis_Homo sapiens_hsa051430.38717778
109Osteoclast differentiation_Homo sapiens_hsa043800.38299333
110Non-small cell lung cancer_Homo sapiens_hsa052230.35708544
111Salmonella infection_Homo sapiens_hsa051320.34115846
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33495905
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32104091
114Basal transcription factors_Homo sapiens_hsa030220.31537933
115Wnt signaling pathway_Homo sapiens_hsa043100.31463018
116Huntingtons disease_Homo sapiens_hsa050160.31132202
117AMPK signaling pathway_Homo sapiens_hsa041520.31129318
118Tight junction_Homo sapiens_hsa045300.31118499
119Oxidative phosphorylation_Homo sapiens_hsa001900.30303077
120ABC transporters_Homo sapiens_hsa020100.29191992
121mTOR signaling pathway_Homo sapiens_hsa041500.28207159
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28040141
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.26909202
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26389444
125Chemokine signaling pathway_Homo sapiens_hsa040620.25687558
126Type I diabetes mellitus_Homo sapiens_hsa049400.23912017
127Bile secretion_Homo sapiens_hsa049760.23533684
128Rap1 signaling pathway_Homo sapiens_hsa040150.23036625
129Insulin signaling pathway_Homo sapiens_hsa049100.21691068
130Ovarian steroidogenesis_Homo sapiens_hsa049130.21022042
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19240081
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13862677

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