NPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)9.23674158
2proline metabolic process (GO:0006560)9.02868170
3replication fork processing (GO:0031297)7.93601136
4embryonic process involved in female pregnancy (GO:0060136)7.82938084
5positive regulation of protein homooligomerization (GO:0032464)7.25801375
6DNA deamination (GO:0045006)6.75363624
7establishment of apical/basal cell polarity (GO:0035089)6.64811431
8regulation of integrin activation (GO:0033623)6.61735722
9oxidative demethylation (GO:0070989)6.42622227
10regulation of protein homooligomerization (GO:0032462)6.27561367
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.26833831
12tachykinin receptor signaling pathway (GO:0007217)6.19477502
13establishment of monopolar cell polarity (GO:0061162)5.77973008
14establishment or maintenance of monopolar cell polarity (GO:0061339)5.77973008
15cellular response to ATP (GO:0071318)5.58481330
16DNA strand renaturation (GO:0000733)5.45355583
17poly(A)+ mRNA export from nucleus (GO:0016973)5.39027876
18negative regulation of JAK-STAT cascade (GO:0046426)5.35783804
19mitochondrial DNA metabolic process (GO:0032042)5.32193501
20somatic hypermutation of immunoglobulin genes (GO:0016446)5.25608909
21somatic diversification of immune receptors via somatic mutation (GO:0002566)5.25608909
22behavioral response to nicotine (GO:0035095)5.18417128
23establishment of protein localization to mitochondrial membrane (GO:0090151)5.01973768
24mitotic G1 DNA damage checkpoint (GO:0031571)4.95321614
25glutamine family amino acid biosynthetic process (GO:0009084)4.93757436
26viral mRNA export from host cell nucleus (GO:0046784)4.88895204
27embryonic placenta development (GO:0001892)4.77040534
28negative regulation of cell cycle arrest (GO:0071157)4.65162928
29parturition (GO:0007567)4.57300131
30G1 DNA damage checkpoint (GO:0044783)4.49581828
31DNA integration (GO:0015074)4.48755005
32mitotic G1/S transition checkpoint (GO:0044819)4.42192648
33positive regulation of developmental pigmentation (GO:0048087)4.41026864
34cellular response to zinc ion (GO:0071294)4.37164628
35negative regulation of protein oligomerization (GO:0032460)4.35542615
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.32552955
37negative regulation of Ras GTPase activity (GO:0034261)4.29055377
38regulation of translational fidelity (GO:0006450)4.25783117
39glial cell migration (GO:0008347)4.25121199
40negative regulation of fatty acid biosynthetic process (GO:0045717)4.24815937
41mRNA cleavage (GO:0006379)4.20558727
42positive regulation by host of viral transcription (GO:0043923)4.16993338
43convergent extension (GO:0060026)4.10044024
44positive regulation of protein oligomerization (GO:0032461)4.08614317
45regulation of cilium movement (GO:0003352)3.99043871
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.97820494
47face development (GO:0060324)3.95501157
48regulation of protein oligomerization (GO:0032459)3.94713222
49base-excision repair (GO:0006284)3.93897885
50negative regulation of heart rate (GO:0010459)3.92920215
51neurofilament cytoskeleton organization (GO:0060052)3.91756888
52GDP-mannose metabolic process (GO:0019673)3.89055297
53embryonic camera-type eye development (GO:0031076)3.88755397
54non-recombinational repair (GO:0000726)3.83811278
55double-strand break repair via nonhomologous end joining (GO:0006303)3.83811278
56piRNA metabolic process (GO:0034587)3.76728394
57nonmotile primary cilium assembly (GO:0035058)3.76625301
58behavioral response to ethanol (GO:0048149)3.75826961
59detection of light stimulus involved in visual perception (GO:0050908)3.74027303
60detection of light stimulus involved in sensory perception (GO:0050962)3.74027303
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.71296577
62mitochondrial RNA metabolic process (GO:0000959)3.66123739
63base-excision repair, AP site formation (GO:0006285)3.64005192
64labyrinthine layer development (GO:0060711)3.62584988
65alkaloid metabolic process (GO:0009820)3.61531439
66DNA ligation (GO:0006266)3.59994830
67protein targeting to vacuole (GO:0006623)3.56826027
68protein targeting to lysosome (GO:0006622)3.56826027
69establishment of protein localization to vacuole (GO:0072666)3.56826027
70auditory receptor cell stereocilium organization (GO:0060088)3.54336913
71pyrimidine nucleobase catabolic process (GO:0006208)3.52566189
72activation of Rac GTPase activity (GO:0032863)3.51994509
73peristalsis (GO:0030432)3.49753222
74regulation of cAMP-dependent protein kinase activity (GO:2000479)3.49710559
75regulation of synapse structural plasticity (GO:0051823)3.49263209
76epithelial cilium movement (GO:0003351)3.46458522
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45805969
78apoptotic process involved in morphogenesis (GO:0060561)3.45761601
79negative regulation of response to food (GO:0032096)3.43963988
80negative regulation of appetite (GO:0032099)3.43963988
81anatomical structure regression (GO:0060033)3.42989634
82formation of translation preinitiation complex (GO:0001731)3.42600759
83photoreceptor cell maintenance (GO:0045494)3.42180836
84regulation of mitochondrial depolarization (GO:0051900)3.42151568
85positive regulation of DNA repair (GO:0045739)3.41289875
86negative regulation of mRNA processing (GO:0050686)3.40026899
87indolalkylamine metabolic process (GO:0006586)3.39501422
88positive regulation of receptor recycling (GO:0001921)3.39154150
89DNA topological change (GO:0006265)3.38849160
90telomere maintenance via semi-conservative replication (GO:0032201)3.37860313
91regulation of RNA export from nucleus (GO:0046831)3.37474079
92DNA double-strand break processing (GO:0000729)3.37071434
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.34552159
94hypotonic response (GO:0006971)3.32771559
95signal complex assembly (GO:0007172)3.31907014
96histone H4-K12 acetylation (GO:0043983)3.31721839
97regulation of response to reactive oxygen species (GO:1901031)3.31023729
98sulfur amino acid catabolic process (GO:0000098)3.29038141
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27769928
100nuclear envelope reassembly (GO:0031468)3.24809593
101mitotic nuclear envelope reassembly (GO:0007084)3.24809593
102dosage compensation (GO:0007549)3.24525929
103trophectodermal cell differentiation (GO:0001829)3.24364353
104gamma-aminobutyric acid transport (GO:0015812)3.23561363
105negative regulation of tumor necrosis factor production (GO:0032720)3.18769677
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16319456
107regulation of sister chromatid cohesion (GO:0007063)3.15792149
108axoneme assembly (GO:0035082)3.15603234
109regulation of podosome assembly (GO:0071801)3.15405626
110protein neddylation (GO:0045116)3.13999613
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.12859244
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12859244
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12859244
114transmission of nerve impulse (GO:0019226)3.12697132
115DNA methylation involved in gamete generation (GO:0043046)3.12006253
116termination of RNA polymerase II transcription (GO:0006369)3.11535679
117synaptic vesicle endocytosis (GO:0048488)3.10453269
118substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09447055
119substrate-independent telencephalic tangential migration (GO:0021826)3.09447055
120regulation of cell size (GO:0008361)3.08359770
121regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.08159845
122negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.07888347
123regulation of hydrogen peroxide-induced cell death (GO:1903205)3.07307979
124meiotic chromosome segregation (GO:0045132)3.06820234
125synaptic transmission, cholinergic (GO:0007271)3.06519777
126locomotory exploration behavior (GO:0035641)3.04557190
127brain morphogenesis (GO:0048854)3.03204102
128cilium or flagellum-dependent cell motility (GO:0001539)2.98356161
129positive regulation of mitochondrial fission (GO:0090141)2.93913482
130cilium movement (GO:0003341)2.93896905
131protein import into peroxisome matrix (GO:0016558)2.91979689
132presynaptic membrane organization (GO:0097090)2.90815336
133regulation of microtubule-based movement (GO:0060632)2.90259226
134reciprocal meiotic recombination (GO:0007131)2.85041558
135reciprocal DNA recombination (GO:0035825)2.85041558
136protein localization to synapse (GO:0035418)2.84345808
137protein polyglutamylation (GO:0018095)2.83737802
138NAD biosynthetic process (GO:0009435)2.82034976
139nucleobase catabolic process (GO:0046113)2.81159368
140postsynaptic membrane organization (GO:0001941)2.80336327
141protein complex biogenesis (GO:0070271)2.78567568
142tryptophan catabolic process (GO:0006569)2.75789972
143indole-containing compound catabolic process (GO:0042436)2.75789972
144indolalkylamine catabolic process (GO:0046218)2.75789972
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73724553
146neuronal action potential propagation (GO:0019227)2.72672357
147phenylpropanoid metabolic process (GO:0009698)2.71904560
148cilium morphogenesis (GO:0060271)2.69836964
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69596903
1503-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67710825
151purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67710825
152microtubule bundle formation (GO:0001578)2.65088065
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60940627
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.60940627
155NADH dehydrogenase complex assembly (GO:0010257)2.60940627
156behavioral response to cocaine (GO:0048148)2.60915683
157neuromuscular synaptic transmission (GO:0007274)2.60489904
158retinal cone cell development (GO:0046549)2.58902645
159positive regulation of growth hormone secretion (GO:0060124)2.57389794
160* neuropeptide signaling pathway (GO:0007218)2.56730553
161synaptic transmission, glutamatergic (GO:0035249)2.55820030
162inner ear receptor stereocilium organization (GO:0060122)2.53845024
163startle response (GO:0001964)2.53605808
164cornea development in camera-type eye (GO:0061303)2.53019930
165respiratory chain complex IV assembly (GO:0008535)2.52740231
166regulation of action potential (GO:0098900)2.52647061
167axonal fasciculation (GO:0007413)2.52298116
168regulation of collateral sprouting (GO:0048670)2.50019485
169ovulation cycle (GO:0042698)2.50010520
170striatum development (GO:0021756)2.48103240
171sulfation (GO:0051923)2.46484880
172mechanosensory behavior (GO:0007638)2.45776755
173mitochondrial respiratory chain complex assembly (GO:0033108)2.45626446
174phasic smooth muscle contraction (GO:0014821)2.45271086
175flavonoid metabolic process (GO:0009812)2.44439187
176male meiosis I (GO:0007141)2.44228681
177synaptic transmission, dopaminergic (GO:0001963)2.44126206
178cilium organization (GO:0044782)2.43100935
179auditory behavior (GO:0031223)2.42832349
180rRNA methylation (GO:0031167)2.42425677
181cilium assembly (GO:0042384)2.41484902
182amine catabolic process (GO:0009310)2.40362684
183cellular biogenic amine catabolic process (GO:0042402)2.40362684
184neuron recognition (GO:0008038)2.40082154
185kynurenine metabolic process (GO:0070189)2.39401050
186indole-containing compound metabolic process (GO:0042430)2.39027326
187membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38980140
188mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36299364
189multicellular organism reproduction (GO:0032504)2.35429718
190photoreceptor cell development (GO:0042461)2.35300171
191regulation of mitochondrial fission (GO:0090140)2.33664966
192neuron-neuron synaptic transmission (GO:0007270)2.32831158
193sensory perception of smell (GO:0007608)2.31078475
194proline biosynthetic process (GO:0006561)11.8313247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98866511
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.86910639
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.86910639
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.86910639
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.61585260
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.58465435
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53014236
8VDR_22108803_ChIP-Seq_LS180_Human3.13421176
9GBX2_23144817_ChIP-Seq_PC3_Human3.02029377
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.97555307
11ZNF274_21170338_ChIP-Seq_K562_Hela2.88101582
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.81718461
13VDR_21846776_ChIP-Seq_THP-1_Human2.54554369
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53554202
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.50288298
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.47946517
17POU5F1_16518401_ChIP-PET_MESCs_Mouse2.46060117
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.41775414
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40527478
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.36643317
21LXR_22292898_ChIP-Seq_THP-1_Human2.36237881
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33029696
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.32784686
24REST_21632747_ChIP-Seq_MESCs_Mouse2.29162802
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25885785
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.18615709
27FUS_26573619_Chip-Seq_HEK293_Human2.10147122
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07889406
29TAF15_26573619_Chip-Seq_HEK293_Human2.06263521
30PU.1_20513432_ChIP-Seq_Bcells_Mouse2.04584819
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.04143603
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98500566
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96141719
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94130575
35EWS_26573619_Chip-Seq_HEK293_Human1.92301137
36IGF1R_20145208_ChIP-Seq_DFB_Human1.91267497
37P300_19829295_ChIP-Seq_ESCs_Human1.87999817
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.86311404
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.83531985
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82237008
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80971279
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79690927
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.79404869
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79349195
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.76487038
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76022586
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75813041
48TP53_22573176_ChIP-Seq_HFKS_Human1.75128698
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75023666
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.74591505
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.74143568
52ER_23166858_ChIP-Seq_MCF-7_Human1.73383502
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73169732
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71331308
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65308571
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.64342904
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.63148512
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62349935
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61824250
60RNF2_27304074_Chip-Seq_NSC_Mouse1.61152141
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60744587
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60535148
63RACK7_27058665_Chip-Seq_MCF-7_Human1.60438794
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59023182
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58623308
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.58206028
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57427940
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56654931
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54566925
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54486757
71STAT3_23295773_ChIP-Seq_U87_Human1.53833261
72ZNF263_19887448_ChIP-Seq_K562_Human1.50210742
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48560098
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48376301
75NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46308465
76SMAD4_21799915_ChIP-Seq_A2780_Human1.46113691
77POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.44224129
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.44143479
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42671719
80CBP_20019798_ChIP-Seq_JUKART_Human1.41676215
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41676215
82TCF4_23295773_ChIP-Seq_U87_Human1.40889871
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.40464650
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39404910
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39259911
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38984312
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.38717686
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38633429
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36041310
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35806643
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34207174
92BCAT_22108803_ChIP-Seq_LS180_Human1.33829776
93* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.32831080
94KDM2B_26808549_Chip-Seq_DND41_Human1.31118427
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30999855
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29495439
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29459183
98AR_21572438_ChIP-Seq_LNCaP_Human1.29379467
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29190970
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28813352
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28582570
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28582570
103* NCOR_22424771_ChIP-Seq_293T_Human1.28083831
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26739626
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25914260
106AR_25329375_ChIP-Seq_VCAP_Human1.25875613
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25727177
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25646279
109* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25592132
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25586891
111* RARB_24833708_ChIP-Seq_LIVER_Mouse1.25496384
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.24677352
113JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24377040
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23933815
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23602090
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23203574
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22451175
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21773102
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21575567
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20758695
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20704751
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20514225
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.20275194
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20157304
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19419638
126STAT1_20625510_ChIP-Seq_HELA_Human1.18776819
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18224433
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17714278
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16883773
130PIAS1_25552417_ChIP-Seq_VCAP_Human1.16747774
131GABP_17652178_ChIP-ChIP_JURKAT_Human1.16087068
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.16048223
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15601495
134CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15540310
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15354482
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14590022
137TP53_20018659_ChIP-ChIP_R1E_Mouse1.12312118
138IRF1_19129219_ChIP-ChIP_H3396_Human1.12296954
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11913319
140MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11562330
141BCOR_27268052_Chip-Seq_Bcells_Human1.10582379
142SALL1_21062744_ChIP-ChIP_HESCs_Human1.10568534
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.10441885
144MYC_19829295_ChIP-Seq_ESCs_Human1.10401850
145EED_16625203_ChIP-ChIP_MESCs_Mouse1.10236476
146* RARA_24833708_ChIP-Seq_LIVER_Mouse1.09863765
147RUNX2_22187159_ChIP-Seq_PCA_Human1.09826038
148SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09250543
149SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09037531
150KDM2B_26808549_Chip-Seq_K562_Human1.09014131
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08760344
152* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08410403
153SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07778795
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07778072
155TCF4_22108803_ChIP-Seq_LS180_Human1.07749966
156OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07742192
157SMAD4_21741376_ChIP-Seq_EPCs_Human1.07648317
158ELK3_25401928_ChIP-Seq_HUVEC_Human1.07635395
159CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07297039
160MYC_22102868_ChIP-Seq_BL_Human1.07214791
161YY1_22570637_ChIP-Seq_MALME-3M_Human1.06975894
162CTCF_27219007_Chip-Seq_Bcells_Human1.06784619
163SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06238597
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06175983
165DROSHA_22980978_ChIP-Seq_HELA_Human1.05833570
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05605990
167E2F1_20622854_ChIP-Seq_HELA_Human1.05256872
168RING1B_27294783_Chip-Seq_NPCs_Mouse1.04407956
169P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04176239
170SA1_27219007_Chip-Seq_ERYTHROID_Human1.03611734
171E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03388720
172NANOG_20526341_ChIP-Seq_ESCs_Human1.03325507
173E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03107797
174SMAD3_21741376_ChIP-Seq_EPCs_Human1.02734702
175POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02623781
176CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02427950
177EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02419862
178NANOG_16518401_ChIP-PET_MESCs_Mouse1.02216453
179SOX2_19829295_ChIP-Seq_ESCs_Human1.02161201
180NANOG_19829295_ChIP-Seq_ESCs_Human1.02161201
181JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01678009
182ERA_21632823_ChIP-Seq_H3396_Human1.00980155
183KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00863745
184ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99452413
185PHF8_20622854_ChIP-Seq_HELA_Human0.99197197
186TET1_21490601_ChIP-Seq_MESCs_Mouse0.99136656
187TAF2_19829295_ChIP-Seq_ESCs_Human0.98699533
188OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98614546
189FLI1_21867929_ChIP-Seq_TH2_Mouse0.96743133
190P53_21459846_ChIP-Seq_SAOS-2_Human0.94794926
191EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93930068
192CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92832765
193JUN_21703547_ChIP-Seq_K562_Human0.91312533
194TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90938371
195HOXB7_26014856_ChIP-Seq_BT474_Human0.90540204
196TAL1_26923725_Chip-Seq_HPCs_Mouse0.89993335
197RNF2_27304074_Chip-Seq_ESCs_Mouse0.89141616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.53918920
2MP0005171_absent_coat_pigmentation5.58836194
3MP0009278_abnormal_bone_marrow4.84208903
4MP0010030_abnormal_orbit_morphology3.76891627
5MP0002009_preneoplasia3.73552891
6MP0004233_abnormal_muscle_weight3.59111692
7MP0001968_abnormal_touch/_nociception2.85469830
8MP0008995_early_reproductive_senescence2.84190572
9MP0006276_abnormal_autonomic_nervous2.80490926
10MP0002736_abnormal_nociception_after2.78133117
11MP0005423_abnormal_somatic_nervous2.70576072
12MP0001986_abnormal_taste_sensitivity2.68313188
13MP0003880_abnormal_central_pattern2.67341365
14MP0002822_catalepsy2.63159973
15MP0006072_abnormal_retinal_apoptosis2.59965454
16MP0003283_abnormal_digestive_organ2.49878105
17MP0003890_abnormal_embryonic-extraembry2.49393362
18MP0003787_abnormal_imprinting2.49022043
19MP0001188_hyperpigmentation2.45523228
20MP0005551_abnormal_eye_electrophysiolog2.42394313
21MP0003123_paternal_imprinting2.33929774
22MP0004133_heterotaxia2.33440949
23MP0003195_calcinosis2.28055557
24MP0005646_abnormal_pituitary_gland2.22223055
25MP0009046_muscle_twitch2.18311326
26MP0002249_abnormal_larynx_morphology2.13120623
27MP0005174_abnormal_tail_pigmentation2.11107223
28MP0002735_abnormal_chemical_nociception2.10838566
29MP0003453_abnormal_keratinocyte_physiol2.10833887
30MP0001545_abnormal_hematopoietic_system2.08421441
31MP0005397_hematopoietic_system_phenotyp2.08421441
32MP0002653_abnormal_ependyma_morphology2.04496648
33MP0001984_abnormal_olfaction2.00340440
34MP0003119_abnormal_digestive_system1.94257488
35MP0000579_abnormal_nail_morphology1.93669792
36MP0002272_abnormal_nervous_system1.89960900
37MP0002282_abnormal_trachea_morphology1.89693509
38MP0010386_abnormal_urinary_bladder1.85258758
39MP0003786_premature_aging1.80650930
40MP0002160_abnormal_reproductive_system1.76729785
41MP0001486_abnormal_startle_reflex1.76344494
42MP0003646_muscle_fatigue1.74147885
43MP0003172_abnormal_lysosome_physiology1.73708668
44MP0000372_irregular_coat_pigmentation1.68375652
45MP0010094_abnormal_chromosome_stability1.67275403
46MP0000462_abnormal_digestive_system1.67243215
47MP0008877_abnormal_DNA_methylation1.66185341
48MP0009745_abnormal_behavioral_response1.63449761
49MP0002638_abnormal_pupillary_reflex1.58340617
50MP0003635_abnormal_synaptic_transmissio1.56825805
51MP0001905_abnormal_dopamine_level1.55356372
52MP0001529_abnormal_vocalization1.53949319
53MP0000639_abnormal_adrenal_gland1.53166120
54MP0005058_abnormal_lysosome_morphology1.52452050
55MP0005076_abnormal_cell_differentiation1.52128455
56MP0002572_abnormal_emotion/affect_behav1.51919736
57MP0003011_delayed_dark_adaptation1.51005939
58* MP0001970_abnormal_pain_threshold1.50858287
59MP0000569_abnormal_digit_pigmentation1.50799690
60MP0000470_abnormal_stomach_morphology1.49601159
61MP0001293_anophthalmia1.49019375
62MP0000015_abnormal_ear_pigmentation1.48452918
63MP0000427_abnormal_hair_cycle1.47689999
64MP0002557_abnormal_social/conspecific_i1.44635789
65MP0004043_abnormal_pH_regulation1.43426574
66MP0002084_abnormal_developmental_patter1.41601773
67MP0003121_genomic_imprinting1.40395832
68MP0005075_abnormal_melanosome_morpholog1.40180675
69MP0002067_abnormal_sensory_capabilities1.39955347
70MP0001340_abnormal_eyelid_morphology1.39208326
71MP0005386_behavior/neurological_phenoty1.36566927
72MP0004924_abnormal_behavior1.36566927
73MP0002086_abnormal_extraembryonic_tissu1.36487066
74MP0002184_abnormal_innervation1.35178149
75MP0000631_abnormal_neuroendocrine_gland1.32667752
76MP0002063_abnormal_learning/memory/cond1.32034770
77MP0003879_abnormal_hair_cell1.30601694
78MP0008932_abnormal_embryonic_tissue1.29631596
79MP0008789_abnormal_olfactory_epithelium1.29600305
80MP0005394_taste/olfaction_phenotype1.29001514
81MP0005499_abnormal_olfactory_system1.29001514
82MP0005645_abnormal_hypothalamus_physiol1.28216267
83MP0004145_abnormal_muscle_electrophysio1.27705919
84MP0002102_abnormal_ear_morphology1.27425389
85MP0002796_impaired_skin_barrier1.26240287
86MP0002269_muscular_atrophy1.25870594
87MP0001697_abnormal_embryo_size1.25723717
88MP0000371_diluted_coat_color1.25514865
89MP0003567_abnormal_fetal_cardiomyocyte1.24493097
90MP0002064_seizures1.24490097
91MP0004142_abnormal_muscle_tone1.23624458
92MP0001485_abnormal_pinna_reflex1.22784062
93MP0002085_abnormal_embryonic_tissue1.22281927
94MP0004197_abnormal_fetal_growth/weight/1.21199446
95MP0000538_abnormal_urinary_bladder1.20670116
96MP0005389_reproductive_system_phenotype1.20197370
97MP0002734_abnormal_mechanical_nocicepti1.18724894
98MP0002752_abnormal_somatic_nervous1.17817661
99MP0000762_abnormal_tongue_morphology1.17543504
100MP0004270_analgesia1.17351698
101MP0002882_abnormal_neuron_morphology1.16598804
102MP0005085_abnormal_gallbladder_physiolo1.16539415
103MP0002909_abnormal_adrenal_gland1.16251369
104MP0002234_abnormal_pharynx_morphology1.14197117
105MP0004957_abnormal_blastocyst_morpholog1.12286781
106MP0002111_abnormal_tail_morphology1.08170835
107MP0005410_abnormal_fertilization1.07846736
108MP0001919_abnormal_reproductive_system1.07685263
109MP0008875_abnormal_xenobiotic_pharmacok1.06771470
110MP0002837_dystrophic_cardiac_calcinosis1.06369583
111MP0002938_white_spotting1.05726998
112MP0003045_fibrosis1.05026979
113MP0002210_abnormal_sex_determination1.04494894
114MP0002932_abnormal_joint_morphology1.04443850
115MP0003136_yellow_coat_color1.04205453
116MP0002229_neurodegeneration1.03297397
117MP0001756_abnormal_urination1.03275638
118MP0003137_abnormal_impulse_conducting1.01087918
119MP0004885_abnormal_endolymph1.00911231
120MP0004859_abnormal_synaptic_plasticity0.99278119
121MP0002928_abnormal_bile_duct0.98865721
122MP0002876_abnormal_thyroid_physiology0.98683921
123MP0005195_abnormal_posterior_eye0.97917975
124MP0008058_abnormal_DNA_repair0.95857595
125MP0005253_abnormal_eye_physiology0.95710184
126MP0010352_gastrointestinal_tract_polyps0.94773973
127MP0001440_abnormal_grooming_behavior0.94452861
128MP0003755_abnormal_palate_morphology0.94447156
129MP0005365_abnormal_bile_salt0.94086759
130MP0003698_abnormal_male_reproductive0.92941100
131MP0001501_abnormal_sleep_pattern0.92605796
132MP0003828_pulmonary_edema0.91776675
133MP0001324_abnormal_eye_pigmentation0.91597936
134MP0000490_abnormal_crypts_of0.90573534
135MP0002114_abnormal_axial_skeleton0.90564527
136MP0000467_abnormal_esophagus_morphology0.89730591
137MP0005332_abnormal_amino_acid0.89393138
138MP0005266_abnormal_metabolism0.87480492
139MP0002116_abnormal_craniofacial_bone0.86037001
140MP0003935_abnormal_craniofacial_develop0.85800642
141MP0004134_abnormal_chest_morphology0.84697603
142MP0001672_abnormal_embryogenesis/_devel0.84447403
143MP0005380_embryogenesis_phenotype0.84447403
144MP0008872_abnormal_physiological_respon0.83679719
145MP0002075_abnormal_coat/hair_pigmentati0.82465528
146MP0004742_abnormal_vestibular_system0.82401603
147MP0000026_abnormal_inner_ear0.81605438
148MP0009115_abnormal_fat_cell0.80024820
149MP0004811_abnormal_neuron_physiology0.79968302
150MP0003656_abnormal_erythrocyte_physiolo0.79722962
151MP0001502_abnormal_circadian_rhythm0.79641735
152MP0005501_abnormal_skin_physiology0.79438796
153MP0004264_abnormal_extraembryonic_tissu0.79034263
154MP0002733_abnormal_thermal_nociception0.78070836
155MP0002163_abnormal_gland_morphology0.78044491
156MP0001963_abnormal_hearing_physiology0.76199806
157MP0000955_abnormal_spinal_cord0.75257452
158MP0006082_CNS_inflammation0.73577262
159MP0001186_pigmentation_phenotype0.73377855
160MP0005330_cardiomyopathy0.72974849
161MP0000685_abnormal_immune_system0.71720142
162MP0003385_abnormal_body_wall0.71546205
163MP0000432_abnormal_head_morphology0.70517490
164MP0003718_maternal_effect0.70356704
165MP0005391_vision/eye_phenotype0.68845841
166MP0002060_abnormal_skin_morphology0.68220050
167MP0002019_abnormal_tumor_incidence0.68136368
168MP0003634_abnormal_glial_cell0.67153722
169MP0005367_renal/urinary_system_phenotyp0.67009345
170MP0000516_abnormal_urinary_system0.67009345
171MP0002108_abnormal_muscle_morphology0.65239893
172MP0005508_abnormal_skeleton_morphology0.64504679
173MP0000778_abnormal_nervous_system0.64495034
174MP0000350_abnormal_cell_proliferation0.64126418
175MP0002332_abnormal_exercise_endurance0.63981515
176MP0001730_embryonic_growth_arrest0.62030348
177MP0002080_prenatal_lethality0.61917272
178MP0004019_abnormal_vitamin_homeostasis0.61748024
179MP0003638_abnormal_response/metabolism_0.57467942
180MP0003111_abnormal_nucleus_morphology0.57108074
181MP0002971_abnormal_brown_adipose0.57005093

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.65185465
2Rib fusion (HP:0000902)5.61049292
3Increased IgM level (HP:0003496)5.32305108
4Annular pancreas (HP:0001734)5.19437990
5Rectal fistula (HP:0100590)5.15802599
6Rectovaginal fistula (HP:0000143)5.15802599
7Facial hemangioma (HP:0000329)5.07682419
8Turricephaly (HP:0000262)5.03407895
9Pustule (HP:0200039)5.02946651
10Alopecia of scalp (HP:0002293)4.73530766
11Intestinal fistula (HP:0100819)4.62246908
12Poikiloderma (HP:0001029)4.58599896
13Vaginal fistula (HP:0004320)4.57825521
14Coronal craniosynostosis (HP:0004440)4.39073465
15Ulnar bowing (HP:0003031)4.34824984
16Abnormal hemoglobin (HP:0011902)4.27298876
17Congenital stationary night blindness (HP:0007642)4.20862918
18Hypochromic microcytic anemia (HP:0004840)4.06037752
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.93479961
20Male infertility (HP:0003251)3.83812019
21Alacrima (HP:0000522)3.81247007
22Intestinal atresia (HP:0011100)3.80983266
23Attenuation of retinal blood vessels (HP:0007843)3.79035179
24Bony spicule pigmentary retinopathy (HP:0007737)3.74380815
25Medial flaring of the eyebrow (HP:0010747)3.73429044
26Anteriorly placed anus (HP:0001545)3.71994007
27Tongue fasciculations (HP:0001308)3.71666704
28Pancreatic cysts (HP:0001737)3.62522918
29Short humerus (HP:0005792)3.62217447
30Molar tooth sign on MRI (HP:0002419)3.58908019
31Abnormality of midbrain morphology (HP:0002418)3.58908019
32Orthostatic hypotension (HP:0001278)3.56217146
33Chorioretinal atrophy (HP:0000533)3.51712161
34Premature skin wrinkling (HP:0100678)3.47643281
35Gait imbalance (HP:0002141)3.47622296
36Aplasia/hypoplasia of the humerus (HP:0006507)3.47281904
37Large for gestational age (HP:0001520)3.45430388
38Muscle fibrillation (HP:0010546)3.37799101
39Abnormality of male internal genitalia (HP:0000022)3.35133030
40Congenital primary aphakia (HP:0007707)3.34272319
41Vertebral hypoplasia (HP:0008417)3.30839632
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.30839632
43Pancreatic islet-cell hyperplasia (HP:0004510)3.30594123
44Congenital hip dislocation (HP:0001374)3.28559293
45Short chin (HP:0000331)3.22075349
46Popliteal pterygium (HP:0009756)3.18485119
47Mucopolysacchariduria (HP:0008155)3.15173544
48Urinary glycosaminoglycan excretion (HP:0003541)3.15173544
49Broad alveolar ridges (HP:0000187)3.15158246
50Pancreatic fibrosis (HP:0100732)3.14173442
51Nephronophthisis (HP:0000090)3.13876682
52Nephrogenic diabetes insipidus (HP:0009806)3.13592587
53Dysautonomia (HP:0002459)3.13285863
54Absent radius (HP:0003974)3.12284235
55Abnormality of the aortic arch (HP:0012303)3.02645535
56Dysostosis multiplex (HP:0000943)3.02531493
57True hermaphroditism (HP:0010459)2.98630617
58Clumsiness (HP:0002312)2.98078554
59Volvulus (HP:0002580)2.97471200
60Hypotrichosis (HP:0001006)2.97172533
61Aplasia involving forearm bones (HP:0009822)2.96010268
62Absent forearm bone (HP:0003953)2.96010268
63Diaphragmatic weakness (HP:0009113)2.94998541
64Chronic hepatic failure (HP:0100626)2.94316057
65Growth hormone excess (HP:0000845)2.93095014
66Hamartoma (HP:0010566)2.92832421
67Squamous cell carcinoma (HP:0002860)2.90940238
68Albinism (HP:0001022)2.88270889
69Decreased lacrimation (HP:0000633)2.86479091
70Abnormality of the renal medulla (HP:0100957)2.85082814
71Choanal stenosis (HP:0000452)2.83437239
72Abnormality of polysaccharide metabolism (HP:0011012)2.81850909
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81850909
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81850909
75Vaginal atresia (HP:0000148)2.75595308
76Hyperventilation (HP:0002883)2.73382276
77Genital tract atresia (HP:0001827)2.72551752
78Aplasia of the musculature (HP:0100854)2.68961298
79Tubular atrophy (HP:0000092)2.66324327
80Abnormality of the renal cortex (HP:0011035)2.65682817
81Hypotelorism (HP:0000601)2.58582851
82Hypokinesia (HP:0002375)2.58329287
83Poor coordination (HP:0002370)2.58235739
84Joint stiffness (HP:0001387)2.56657205
85Basal cell carcinoma (HP:0002671)2.56184098
86Bifid uvula (HP:0000193)2.56090332
87Amelogenesis imperfecta (HP:0000705)2.54463000
88Split hand (HP:0001171)2.53252196
89Progressive cerebellar ataxia (HP:0002073)2.52624771
90Absent speech (HP:0001344)2.51210381
91Absent thumb (HP:0009777)2.47931885
92Polycythemia (HP:0001901)2.47048146
93Abnormality of macular pigmentation (HP:0008002)2.46053994
94Patellar aplasia (HP:0006443)2.45648010
95Bowing of the arm (HP:0006488)2.44660901
96Bowed forearm bones (HP:0003956)2.44660901
97Narrow nasal bridge (HP:0000446)2.40729163
98Retinitis pigmentosa (HP:0000510)2.40275613
99Abnormal rod and cone electroretinograms (HP:0008323)2.38660143
100Abnormal drinking behavior (HP:0030082)2.37047521
101Polydipsia (HP:0001959)2.37047521
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.36102901
103Absent/shortened dynein arms (HP:0200106)2.36102901
104Vertebral fusion (HP:0002948)2.36094704
105Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35036504
106Capillary hemangiomas (HP:0005306)2.34205078
107Hypercortisolism (HP:0001578)2.34105136
108Acute necrotizing encephalopathy (HP:0006965)2.32537964
109Gastrointestinal atresia (HP:0002589)2.30805389
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30614189
111Increased CSF lactate (HP:0002490)2.27916718
112Pendular nystagmus (HP:0012043)2.27596913
113Lower limb hyperreflexia (HP:0002395)2.23863366
114Broad-based gait (HP:0002136)2.23862998
115Bulbar palsy (HP:0001283)2.23808345
116Cystic liver disease (HP:0006706)2.22934025
117Aplasia/Hypoplasia of the patella (HP:0006498)2.22178132
118Acute encephalopathy (HP:0006846)2.21484411
119Premature graying of hair (HP:0002216)2.21189046
120Abnormality of the labia minora (HP:0012880)2.21149264
121Increased number of teeth (HP:0011069)2.21146115
122Mitochondrial inheritance (HP:0001427)2.20777211
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19683686
124Redundant skin (HP:0001582)2.16797042
125Progressive macrocephaly (HP:0004481)2.15305976
126IgA deficiency (HP:0002720)2.14919087
127Decreased central vision (HP:0007663)2.14680458
128Hypoplasia of the radius (HP:0002984)2.14616965
129Sclerocornea (HP:0000647)2.14552845
130Decreased circulating renin level (HP:0003351)2.14349473
131Hypochromic anemia (HP:0001931)2.13098001
132Abolished electroretinogram (ERG) (HP:0000550)2.12863913
133Abnormal mitochondria in muscle tissue (HP:0008316)2.11976779
134Diminished movement (HP:0002374)2.11135805
135Methylmalonic aciduria (HP:0012120)2.10434591
136Type 2 muscle fiber atrophy (HP:0003554)2.10190227
137Protruding tongue (HP:0010808)2.09987408
138Hypoplasia of the ulna (HP:0003022)2.09751770
139Cerebral aneurysm (HP:0004944)2.07066414
140Abnormality of endocrine pancreas physiology (HP:0012093)2.06615897
141Abnormality of the pancreatic islet cells (HP:0006476)2.06615897
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05916895
143Abnormality of alanine metabolism (HP:0010916)2.05916895
144Hyperalaninemia (HP:0003348)2.05916895
145Genetic anticipation (HP:0003743)2.05841853
146Selective tooth agenesis (HP:0001592)2.04845897
147Gaze-evoked nystagmus (HP:0000640)2.03974800
148Congenital hepatic fibrosis (HP:0002612)2.03855411
149Aplasia/Hypoplasia of the lens (HP:0008063)2.02770635
150Fetal akinesia sequence (HP:0001989)2.01882122
151Exertional dyspnea (HP:0002875)2.01286559
152Agitation (HP:0000713)1.98532165
153Congenital sensorineural hearing impairment (HP:0008527)1.98344752
154Adrenal hypoplasia (HP:0000835)1.96775067
155Thickened helices (HP:0000391)1.95697392
156Retinal dysplasia (HP:0007973)1.95507143
157Abnormal pancreas size (HP:0012094)1.94498857
158Asymmetric septal hypertrophy (HP:0001670)1.94360997
159Renal cortical cysts (HP:0000803)1.93367495
160Renal Fanconi syndrome (HP:0001994)1.93320895
161Polyphagia (HP:0002591)1.92796658
162Male pseudohermaphroditism (HP:0000037)1.92203791
163Left ventricular hypertrophy (HP:0001712)1.90310557
164Polyuria (HP:0000103)1.88220207
165Optic disc pallor (HP:0000543)1.88160342
166Amniotic constriction ring (HP:0009775)1.87908912
167Abnormality of placental membranes (HP:0011409)1.87908912
168Abnormal respiratory epithelium morphology (HP:0012253)1.87874191
169Abnormal respiratory motile cilium morphology (HP:0005938)1.87874191
170Tubulointerstitial nephritis (HP:0001970)1.87486123
171Neoplasm of the adrenal cortex (HP:0100641)1.87220913
172Type II lissencephaly (HP:0007260)1.87197064
173Lipid accumulation in hepatocytes (HP:0006561)1.86961157
174Hyperparathyroidism (HP:0000843)1.86429704
175Abnormal respiratory motile cilium physiology (HP:0012261)1.85862874
176Abnormal ciliary motility (HP:0012262)1.85003677
1773-Methylglutaconic aciduria (HP:0003535)1.81385675
178Multicystic kidney dysplasia (HP:0000003)1.80039284
179Poor suck (HP:0002033)1.78858931
180Abnormality of renal resorption (HP:0011038)1.76425392
181Focal seizures (HP:0007359)1.76286241
182Astigmatism (HP:0000483)1.76195829
183Small hand (HP:0200055)1.74694972
184Short foot (HP:0001773)1.73828041
185Increased hepatocellular lipid droplets (HP:0006565)1.73789300
186Abnormal biliary tract physiology (HP:0012439)1.72912569
187Bile duct proliferation (HP:0001408)1.72912569
188Specific learning disability (HP:0001328)1.71781654
189Prominent nasal bridge (HP:0000426)1.71186099
190Enlarged kidneys (HP:0000105)1.71061362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.23267379
2MAPK156.01281179
3FRK5.93362849
4DDR25.12061432
5MAP3K64.75004657
6CASK3.78922237
7MAP3K113.30396177
8PINK13.30155552
9FGR3.13464061
10BMPR1B3.11956970
11TYRO33.07602335
12UHMK12.96998500
13ADRBK22.87335150
14MATK2.84065064
15NTRK32.70544507
16WNK42.50161495
17DAPK12.43562319
18STK162.42785799
19MARK12.40782483
20PIM22.35460739
21BMX2.30755195
22PRKD22.30447402
23YES12.29594438
24MAP3K42.22957909
25CSK2.22806470
26DYRK1B2.21907285
27ACVR1B2.18870310
28NUAK12.13684024
29MUSK1.99025913
30PDGFRA1.97290461
31MAP2K71.93508828
32GRK11.92542228
33MAP4K21.91310677
34LATS11.81823212
35ZAK1.66546933
36STK391.51134925
37TRIM281.48739115
38MAPK131.48201314
39CDK71.44338793
40MINK11.39004587
41DAPK21.38909103
42AKT31.38182255
43CDK61.36233983
44TRPM71.33903352
45PRKCG1.33690403
46WNK31.33647894
47CSNK1G21.29812417
48RPS6KC11.27444818
49RPS6KL11.27444818
50PIM11.26556036
51INSRR1.23043446
52PHKG11.21680906
53PHKG21.21680906
54ADRBK11.20572581
55CAMKK21.20408673
56CDC42BPA1.18278621
57LATS21.17808650
58PIK3CG1.12872159
59GSK3A1.10727869
60RPS6KA61.10427836
61EPHA41.10061318
62TLK11.09449883
63PAK31.06894655
64HIPK21.02018388
65OXSR10.99700457
66PRPF4B0.99469417
67MAPK110.97483945
68TAF10.97450945
69PDK20.96420229
70CSNK1G30.94713089
71CSNK1A1L0.93209783
72SGK2230.85112892
73SGK4940.85112892
74SIK20.84428492
75CHEK20.81066761
76EIF2AK30.78864749
77PLK20.78211732
78PRKCE0.77895018
79PNCK0.76409260
80BCKDK0.72025756
81DYRK30.71261805
82STK38L0.70431792
83CAMK1G0.70305321
84PLK40.69032464
85BCR0.68255865
86CAMK2B0.67804713
87BLK0.67131892
88CDK50.66587590
89PRKAA10.65162884
90MAP3K100.64483973
91GRK50.64150254
92BRAF0.64034738
93SGK20.63915723
94MST1R0.63912674
95WNK10.63079130
96RPS6KA10.63033722
97PRKCI0.62580469
98MAP3K90.59206713
99RAF10.59182837
100CAMK1D0.58610057
101MTOR0.57085181
102CAMK2G0.53876541
103PRKACA0.53313022
104ARAF0.52000291
105MAP2K40.51977820
106PLK10.51398398
107VRK10.48390848
108MAPKAPK30.47989266
109PKN10.46061171
110NEK20.45108020
111TAOK30.44587254
112EGFR0.44080242
113CAMK10.43961429
114CSNK1G10.43908723
115DYRK20.43323342
116CAMK2D0.41165094
117RIPK10.40411278
118CAMK2A0.39104119
119PDGFRB0.38898629
120CSNK1A10.38259243
121IRAK20.37900849
122TAOK20.37769031
123CSNK1E0.37201781
124CSNK1D0.36816366
125LYN0.36703430
126DYRK1A0.36666416
127CSNK2A10.34176548
128MAPKAPK50.34159383
129PRKG10.34081372
130CAMKK10.33784945
131PRKD30.33614574
132STK110.32964407
133RPS6KB10.32739037
134PRKAA20.32506425
135EIF2AK10.32437487
136CAMK40.32233170
137CDK20.32198018
138RPS6KB20.32130634
139ERBB30.31666142
140RPS6KA20.31275303
141MAPK40.31092160
142MAPK10.30821226
143MAPK30.30705636
144MAPK100.29275690
145CDK80.29113405
146PRKCH0.28719103
147RPS6KA50.28352142
148PTK20.26683130
149EPHA20.26433018
150INSR0.26116065
151CDK150.25323858
152CDK11A0.25106149
153PRKD10.24930139
154TNK20.24462436
155MAPK140.24409687
156SGK10.23923248
157ATR0.22266146
158PRKCZ0.22165760
159CDK180.21437239
160MAPKAPK20.20497253
161AURKA0.20372510
162CSNK2A20.20039574
163STK30.18700713
164PAK20.18110605
165RPS6KA30.16519266
166CDK140.16004825
167EPHB10.15989027
168CDK10.15836547
169TRIB30.15297469
170PAK60.14814716
171DMPK0.14445076
172PRKACG0.14372118
173NTRK20.13693513
174ALK0.13443422
175PRKCD0.13286717
176ATM0.11686096
177CHEK10.11653759
178MET0.11437504
179GSK3B0.11435996
180MARK20.11134904
181ABL10.10781077
182AKT10.08543197
183PAK10.08475843

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.50036911
2Mismatch repair_Homo sapiens_hsa034304.74568472
3Base excision repair_Homo sapiens_hsa034104.67576729
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.19614719
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.12159476
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.11897107
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.10991606
8DNA replication_Homo sapiens_hsa030303.04047459
9Nicotine addiction_Homo sapiens_hsa050333.03038013
10Phototransduction_Homo sapiens_hsa047442.77579274
11Arginine and proline metabolism_Homo sapiens_hsa003302.55318104
12Circadian rhythm_Homo sapiens_hsa047102.45710033
13Oxidative phosphorylation_Homo sapiens_hsa001902.45543751
14Hedgehog signaling pathway_Homo sapiens_hsa043402.17983939
15Nucleotide excision repair_Homo sapiens_hsa034202.14886168
16Notch signaling pathway_Homo sapiens_hsa043302.14734027
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11007236
18Hippo signaling pathway_Homo sapiens_hsa043902.05217839
19mTOR signaling pathway_Homo sapiens_hsa041502.03306440
20Parkinsons disease_Homo sapiens_hsa050121.96997264
21Fatty acid metabolism_Homo sapiens_hsa012121.84186442
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78445900
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74842606
24mRNA surveillance pathway_Homo sapiens_hsa030151.66764006
25Butanoate metabolism_Homo sapiens_hsa006501.64498455
26Morphine addiction_Homo sapiens_hsa050321.62029083
27Adherens junction_Homo sapiens_hsa045201.61145213
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58603377
29Fanconi anemia pathway_Homo sapiens_hsa034601.55385405
30Biosynthesis of amino acids_Homo sapiens_hsa012301.53596914
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51507928
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.50606227
33Sulfur relay system_Homo sapiens_hsa041221.50345821
34Glutamatergic synapse_Homo sapiens_hsa047241.50116816
35Spliceosome_Homo sapiens_hsa030401.48268563
36Taste transduction_Homo sapiens_hsa047421.47997509
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44353308
38TGF-beta signaling pathway_Homo sapiens_hsa043501.43792641
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41226809
40Tryptophan metabolism_Homo sapiens_hsa003801.41071044
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.40039268
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.37439835
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37021973
44Folate biosynthesis_Homo sapiens_hsa007901.36578921
45Wnt signaling pathway_Homo sapiens_hsa043101.36307638
46Basal transcription factors_Homo sapiens_hsa030221.35739112
47GABAergic synapse_Homo sapiens_hsa047271.35666863
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33517072
49Alzheimers disease_Homo sapiens_hsa050101.32284183
50Homologous recombination_Homo sapiens_hsa034401.30896294
51Selenocompound metabolism_Homo sapiens_hsa004501.30191308
52Sphingolipid metabolism_Homo sapiens_hsa006001.29253807
53p53 signaling pathway_Homo sapiens_hsa041151.27963687
54Bladder cancer_Homo sapiens_hsa052191.26060886
55Circadian entrainment_Homo sapiens_hsa047131.25886168
56Ovarian steroidogenesis_Homo sapiens_hsa049131.25841288
57Serotonergic synapse_Homo sapiens_hsa047261.23599498
58Collecting duct acid secretion_Homo sapiens_hsa049661.23563731
59Synaptic vesicle cycle_Homo sapiens_hsa047211.23196630
60Ether lipid metabolism_Homo sapiens_hsa005651.22719147
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22636758
62Basal cell carcinoma_Homo sapiens_hsa052171.21956760
63Steroid biosynthesis_Homo sapiens_hsa001001.21361996
64Chemical carcinogenesis_Homo sapiens_hsa052041.18684762
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18554024
66Arginine biosynthesis_Homo sapiens_hsa002201.15703294
67RNA transport_Homo sapiens_hsa030131.15323247
68VEGF signaling pathway_Homo sapiens_hsa043701.10445089
69Insulin secretion_Homo sapiens_hsa049111.10007513
70Lysine degradation_Homo sapiens_hsa003101.09596088
71Fatty acid elongation_Homo sapiens_hsa000621.08330263
72Retinol metabolism_Homo sapiens_hsa008301.08082170
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07429659
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06951521
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05239939
76Regulation of autophagy_Homo sapiens_hsa041401.03697446
77Shigellosis_Homo sapiens_hsa051311.02098304
78Propanoate metabolism_Homo sapiens_hsa006401.01555297
79Fructose and mannose metabolism_Homo sapiens_hsa000511.01253150
80Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00786700
81Peroxisome_Homo sapiens_hsa041461.00612268
82Cocaine addiction_Homo sapiens_hsa050300.99342183
83Nitrogen metabolism_Homo sapiens_hsa009100.98993483
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.98077034
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97177856
86Olfactory transduction_Homo sapiens_hsa047400.96096957
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.95163522
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91920257
89Dopaminergic synapse_Homo sapiens_hsa047280.91191820
90Dorso-ventral axis formation_Homo sapiens_hsa043200.89016564
91ABC transporters_Homo sapiens_hsa020100.86296993
92ErbB signaling pathway_Homo sapiens_hsa040120.82043312
93Oocyte meiosis_Homo sapiens_hsa041140.81698595
94RNA polymerase_Homo sapiens_hsa030200.79737457
95Calcium signaling pathway_Homo sapiens_hsa040200.79288094
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79038537
97Colorectal cancer_Homo sapiens_hsa052100.77915196
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77092213
99Tight junction_Homo sapiens_hsa045300.76306239
100Fatty acid degradation_Homo sapiens_hsa000710.75793086
101Choline metabolism in cancer_Homo sapiens_hsa052310.75733756
102Cell cycle_Homo sapiens_hsa041100.75357238
103Cholinergic synapse_Homo sapiens_hsa047250.74846484
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73896116
105Gap junction_Homo sapiens_hsa045400.72297621
106Metabolic pathways_Homo sapiens_hsa011000.71941372
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.71802328
108Arachidonic acid metabolism_Homo sapiens_hsa005900.71517559
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69404105
110Primary immunodeficiency_Homo sapiens_hsa053400.68427153
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64449592
112Protein export_Homo sapiens_hsa030600.61040482
113beta-Alanine metabolism_Homo sapiens_hsa004100.60347333
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59419041
115MicroRNAs in cancer_Homo sapiens_hsa052060.59116470
116Glutathione metabolism_Homo sapiens_hsa004800.58241433
117Axon guidance_Homo sapiens_hsa043600.56295997
118Caffeine metabolism_Homo sapiens_hsa002320.55297801
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53221861
120AMPK signaling pathway_Homo sapiens_hsa041520.50233481
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.49660379
122Viral myocarditis_Homo sapiens_hsa054160.48243623
123Amphetamine addiction_Homo sapiens_hsa050310.48057451
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.47568037
125Salivary secretion_Homo sapiens_hsa049700.47207363
126Sulfur metabolism_Homo sapiens_hsa009200.46407255
127Pyruvate metabolism_Homo sapiens_hsa006200.46230683
128One carbon pool by folate_Homo sapiens_hsa006700.45035326
129Chronic myeloid leukemia_Homo sapiens_hsa052200.44018821
130Oxytocin signaling pathway_Homo sapiens_hsa049210.43711200
131Ribosome_Homo sapiens_hsa030100.42467608
132Acute myeloid leukemia_Homo sapiens_hsa052210.42173639
133cAMP signaling pathway_Homo sapiens_hsa040240.39842804
134Insulin signaling pathway_Homo sapiens_hsa049100.39691486
135MAPK signaling pathway_Homo sapiens_hsa040100.37756773
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37614455
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37369818
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37355429
139Mineral absorption_Homo sapiens_hsa049780.34912908
140RNA degradation_Homo sapiens_hsa030180.34069738
141Purine metabolism_Homo sapiens_hsa002300.31869738
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31558274
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31176781
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30183803
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29704820
146Endocytosis_Homo sapiens_hsa041440.25762978
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24097012
148Viral carcinogenesis_Homo sapiens_hsa052030.22408911
149Proteoglycans in cancer_Homo sapiens_hsa052050.22161644
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22115561
151Galactose metabolism_Homo sapiens_hsa000520.20557435
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18887983
153Small cell lung cancer_Homo sapiens_hsa052220.18615877
154Linoleic acid metabolism_Homo sapiens_hsa005910.18553348
155Focal adhesion_Homo sapiens_hsa045100.15669232
156Prostate cancer_Homo sapiens_hsa052150.15470066
157Cardiac muscle contraction_Homo sapiens_hsa042600.14961879
158Endometrial cancer_Homo sapiens_hsa052130.14357150
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.13113039
160Lysosome_Homo sapiens_hsa041420.12659493
161Thyroid cancer_Homo sapiens_hsa052160.12215787
162Pathways in cancer_Homo sapiens_hsa052000.10606923
163alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10548365
164Huntingtons disease_Homo sapiens_hsa050160.10182289
165Legionellosis_Homo sapiens_hsa051340.09799699
166Glycerolipid metabolism_Homo sapiens_hsa005610.07720710
167Fat digestion and absorption_Homo sapiens_hsa049750.07541963
168GnRH signaling pathway_Homo sapiens_hsa049120.07362395
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07256768
170Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07013658
171Estrogen signaling pathway_Homo sapiens_hsa049150.06807263
172Sphingolipid signaling pathway_Homo sapiens_hsa040710.06688666
173Long-term depression_Homo sapiens_hsa047300.06013300

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »