NPBWR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.84082273
2desmosome organization (GO:0002934)5.50525241
3cell-substrate junction assembly (GO:0007044)5.14892579
4daunorubicin metabolic process (GO:0044597)5.01096895
5polyketide metabolic process (GO:0030638)5.01096895
6doxorubicin metabolic process (GO:0044598)5.01096895
7axonemal dynein complex assembly (GO:0070286)4.98070585
8regulation of transforming growth factor beta2 production (GO:0032909)4.91445993
9protein localization to endosome (GO:0036010)4.88574401
10negative regulation of keratinocyte proliferation (GO:0010839)4.87726947
11keratinocyte proliferation (GO:0043616)4.79689416
12glomerular basement membrane development (GO:0032836)4.76513574
13cell adhesion mediated by integrin (GO:0033627)4.65440696
14cellular copper ion homeostasis (GO:0006878)4.59328478
15positive regulation of cellular amide metabolic process (GO:0034250)4.54520261
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.33573203
17establishment of planar polarity (GO:0001736)4.08115818
18establishment of tissue polarity (GO:0007164)4.08115818
19superoxide anion generation (GO:0042554)4.06193265
20mesodermal cell differentiation (GO:0048333)3.98999880
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95595847
22regulation of water loss via skin (GO:0033561)3.95485528
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.86614783
24neuron cell-cell adhesion (GO:0007158)3.85316578
25lung epithelium development (GO:0060428)3.84181498
26dopamine transport (GO:0015872)3.84139622
27regulation of keratinocyte proliferation (GO:0010837)3.80115287
28mating behavior (GO:0007617)3.79759564
29diterpenoid biosynthetic process (GO:0016102)3.74667220
30lateral sprouting from an epithelium (GO:0060601)3.74591224
31positive regulation of keratinocyte differentiation (GO:0045618)3.68856497
32primary alcohol catabolic process (GO:0034310)3.68113242
33establishment of skin barrier (GO:0061436)3.63934586
34cerebral cortex radially oriented cell migration (GO:0021799)3.62726408
35presynaptic membrane assembly (GO:0097105)3.60424975
36microglial cell activation (GO:0001774)3.52850525
37positive regulation of hormone biosynthetic process (GO:0046886)3.51559859
38detection of molecule of bacterial origin (GO:0032490)3.47960559
39multicellular organismal water homeostasis (GO:0050891)3.47046576
40positive regulation of heat generation (GO:0031652)3.42906459
41positive regulation of epidermal cell differentiation (GO:0045606)3.41701172
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.40266831
43response to pheromone (GO:0019236)3.37489693
44motile cilium assembly (GO:0044458)3.37115932
45cilium or flagellum-dependent cell motility (GO:0001539)3.34199018
46phosphate ion transmembrane transport (GO:0035435)3.31990892
47substrate-dependent cell migration (GO:0006929)3.31021722
48camera-type eye morphogenesis (GO:0048593)3.30796688
49postsynaptic membrane organization (GO:0001941)3.27589771
50negative regulation of stress fiber assembly (GO:0051497)3.23561924
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22572290
52presynaptic membrane organization (GO:0097090)3.21539472
53endodermal cell differentiation (GO:0035987)3.20010388
54hypotonic response (GO:0006971)3.19732688
55epithelial cell-cell adhesion (GO:0090136)3.19415995
56focal adhesion assembly (GO:0048041)3.19219710
57cell-substrate adherens junction assembly (GO:0007045)3.19219710
58skeletal muscle adaptation (GO:0043501)3.19196824
59glomerular epithelial cell development (GO:0072310)3.15370518
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13069190
61regulation of activation of Janus kinase activity (GO:0010533)3.12966212
62activation of Rac GTPase activity (GO:0032863)3.11721991
63positive regulation of extracellular matrix organization (GO:1903055)3.10059642
64protein hydroxylation (GO:0018126)3.07898801
65positive regulation of uterine smooth muscle contraction (GO:0070474)3.06491575
66peptidyl-proline hydroxylation (GO:0019511)3.06474317
67protein localization to microtubule (GO:0035372)3.05832758
68startle response (GO:0001964)3.04177542
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02918610
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.02918610
71modulation by symbiont of host immune response (GO:0052553)3.02918610
72positive regulation by symbiont of host defense response (GO:0052509)3.02918610
73modulation by symbiont of host defense response (GO:0052031)3.02918610
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02918610
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99253114
76dopamine biosynthetic process (GO:0042416)2.98642878
77adherens junction assembly (GO:0034333)2.97948200
78aminoglycoside antibiotic metabolic process (GO:0030647)2.97458614
79* opioid receptor signaling pathway (GO:0038003)2.96864039
80copper ion homeostasis (GO:0055070)2.95712179
81asymmetric protein localization (GO:0008105)2.95503829
82regulation of response to tumor cell (GO:0002834)2.95419941
83positive regulation of response to tumor cell (GO:0002836)2.95419941
84positive regulation of immune response to tumor cell (GO:0002839)2.95419941
85regulation of immune response to tumor cell (GO:0002837)2.95419941
86glutamate receptor signaling pathway (GO:0007215)2.95134881
87regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.93326800
88negative regulation of mast cell activation (GO:0033004)2.92834692
89semaphorin-plexin signaling pathway (GO:0071526)2.92375605
90regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.92236356
91respiratory burst (GO:0045730)2.90831408
92synaptic transmission, glutamatergic (GO:0035249)2.90749863
93regulation of synapse maturation (GO:0090128)2.88723981
94phagosome maturation (GO:0090382)2.88091879
95positive regulation of epidermis development (GO:0045684)2.87570036
96gap junction assembly (GO:0016264)2.87528195
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.87311634
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87146584
99renal filtration (GO:0097205)2.86822709
100energy homeostasis (GO:0097009)2.86283573
101regulation of fever generation (GO:0031620)2.85369893
102positive regulation of adherens junction organization (GO:1903393)2.84699315
103cell junction assembly (GO:0034329)2.84666546
104auditory receptor cell stereocilium organization (GO:0060088)2.83292281
105negative regulation of chondrocyte differentiation (GO:0032331)2.82640950
106positive regulation of cell junction assembly (GO:1901890)2.82489870
107positive regulation of focal adhesion assembly (GO:0051894)2.82489870
108regulation of heat generation (GO:0031650)2.81623472
109vocalization behavior (GO:0071625)2.81470657
110cell junction organization (GO:0034330)2.80770215
111response to peptidoglycan (GO:0032494)2.78865903
112positive regulation of neurotransmitter secretion (GO:0001956)2.78161492
113protein localization to cell surface (GO:0034394)2.77818244
114water homeostasis (GO:0030104)2.76081860
115cellular response to vitamin D (GO:0071305)2.74943094
116positive regulation of positive chemotaxis (GO:0050927)2.74881316
117serotonin receptor signaling pathway (GO:0007210)2.73592697
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73338030
119response to host immune response (GO:0052572)2.73338030
120neuron-neuron synaptic transmission (GO:0007270)2.71403980
121morphogenesis of embryonic epithelium (GO:0016331)2.71064350
122surfactant homeostasis (GO:0043129)2.69242589
123phosphate ion transport (GO:0006817)2.69236662
124positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.67535279
125developmental pigmentation (GO:0048066)2.67419422
126skin morphogenesis (GO:0043589)2.67316115
127membrane tubulation (GO:0097320)2.67061954
128endothelial cell chemotaxis (GO:0035767)2.66760679
129positive regulation of hormone metabolic process (GO:0032352)2.66649705
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65853548
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65757626
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65391239
133neuron remodeling (GO:0016322)2.65314068
134regulation of catecholamine metabolic process (GO:0042069)2.64182538
135regulation of dopamine metabolic process (GO:0042053)2.64182538
136cilium movement (GO:0003341)2.63931676
137response to gravity (GO:0009629)2.63634903
138macrophage activation (GO:0042116)2.61308757
139regulation of apoptotic process involved in morphogenesis (GO:1902337)2.60890577
140regulation of positive chemotaxis (GO:0050926)2.60436848
141retinoic acid metabolic process (GO:0042573)2.60047493
142regulation of transforming growth factor beta production (GO:0071634)2.55992689
143adherens junction organization (GO:0034332)2.54379581
144urinary tract smooth muscle contraction (GO:0014848)2.53893801
145extracellular matrix disassembly (GO:0022617)2.53802609
146detection of external biotic stimulus (GO:0098581)2.51578536
147negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51003106
148SMAD protein complex assembly (GO:0007183)2.50387083
149negative regulation of neurotransmitter transport (GO:0051589)2.50159635
150regulation of transforming growth factor beta1 production (GO:0032908)2.49687801
151negative regulation of fatty acid transport (GO:2000192)2.49065557
152G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49014646
153epidermis development (GO:0008544)2.48997516
154regulation of glutamate receptor signaling pathway (GO:1900449)2.48882424
155branching involved in salivary gland morphogenesis (GO:0060445)2.48554240
156cell-cell junction maintenance (GO:0045217)2.48060609
157hippo signaling (GO:0035329)2.47976248
158neurotransmitter-gated ion channel clustering (GO:0072578)2.46362696
159response to cocaine (GO:0042220)2.45494610
160positive regulation of type 2 immune response (GO:0002830)2.44956920
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44120565
162catecholamine transport (GO:0051937)2.43297855
163regulation of uterine smooth muscle contraction (GO:0070472)2.42646448
164eosinophil chemotaxis (GO:0048245)2.41445502
165cellular anion homeostasis (GO:0030002)2.40004067
166transmission of nerve impulse (GO:0019226)2.39832712
167regulation of platelet aggregation (GO:0090330)2.39013989
168nucleotide transmembrane transport (GO:1901679)2.38831916
169synaptic vesicle endocytosis (GO:0048488)2.37594679
170positive regulation of interleukin-10 production (GO:0032733)2.34676994
171long-chain fatty acid biosynthetic process (GO:0042759)2.34540756
172regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.34432406
173positive regulation of interleukin-17 production (GO:0032740)2.32957912
174dentate gyrus development (GO:0021542)2.31360613
175neutrophil activation involved in immune response (GO:0002283)2.30955776
176ganglioside metabolic process (GO:0001573)2.30522131
177prostate gland growth (GO:0060736)2.30403495
178inner ear receptor stereocilium organization (GO:0060122)2.29771564
179righting reflex (GO:0060013)2.28572969
180G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.27838396
181regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27671340
182ceramide catabolic process (GO:0046514)2.27285970
183regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.27119453
184positive regulation of monocyte chemotaxis (GO:0090026)2.26801936
185regulation of inositol phosphate biosynthetic process (GO:0010919)2.26377480
186protein localization to synapse (GO:0035418)2.26074846
187detection of light stimulus involved in sensory perception (GO:0050962)2.25961172
188detection of light stimulus involved in visual perception (GO:0050908)2.25961172
189response to auditory stimulus (GO:0010996)2.25523750
190intracellular pH reduction (GO:0051452)2.24610703
191positive regulation of synaptic transmission, GABAergic (GO:0032230)2.24573681
192negative regulation of systemic arterial blood pressure (GO:0003085)2.23018515
193regulation of synaptic transmission, glutamatergic (GO:0051966)2.22592898
194neutrophil activation (GO:0042119)2.22291086
195regulation of interleukin-17 production (GO:0032660)2.22119306
196G-protein coupled receptor internalization (GO:0002031)2.20787342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.50963174
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.55757158
3GBX2_23144817_ChIP-Seq_PC3_Human4.14657222
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.98974523
5EZH2_22144423_ChIP-Seq_EOC_Human3.78566961
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.71866530
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65060405
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.11801993
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90401690
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76463705
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73482060
12ZNF263_19887448_ChIP-Seq_K562_Human2.66099579
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.47122679
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.41993098
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40680592
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33848617
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.31219390
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31181303
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.31028899
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28942184
21TAF15_26573619_Chip-Seq_HEK293_Human2.28876537
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27018577
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.23900684
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.23900684
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.19913439
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.15838927
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.14808563
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14351683
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14330191
30SOX9_24532713_ChIP-Seq_HFSC_Mouse2.12702185
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10521513
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.10438416
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.07619700
34* LXR_22292898_ChIP-Seq_THP-1_Human2.07389161
35RACK7_27058665_Chip-Seq_MCF-7_Human2.05094542
36BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03725024
37P63_26484246_Chip-Seq_KERATINOCYTES_Human2.02664029
38P300_19829295_ChIP-Seq_ESCs_Human2.00254696
39* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99637998
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95422655
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.86788709
42* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86387886
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85692123
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.83365373
45* FLI1_27457419_Chip-Seq_LIVER_Mouse1.81603078
46IGF1R_20145208_ChIP-Seq_DFB_Human1.78963575
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77660352
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74899144
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73365938
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73365938
51* ERG_21242973_ChIP-ChIP_JURKAT_Human1.70680894
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70251558
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69743036
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68054342
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67920167
56* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67094103
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66308263
58* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66137773
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.66072598
60* NANOG_18555785_Chip-Seq_ESCs_Mouse1.65043964
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64296110
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.64241176
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63265661
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63209215
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61438138
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60373186
67* E2F1_18555785_Chip-Seq_ESCs_Mouse1.60125891
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.59704094
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59490436
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59454207
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57543345
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57373596
73* NFE2_27457419_Chip-Seq_LIVER_Mouse1.57237471
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57044083
75* RNF2_27304074_Chip-Seq_ESCs_Mouse1.57015173
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.56683340
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56302496
78TP53_18474530_ChIP-ChIP_U2OS_Human1.54446962
79DROSHA_22980978_ChIP-Seq_HELA_Human1.53910510
80* P53_22387025_ChIP-Seq_ESCs_Mouse1.53887931
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.52553613
82* KLF5_25053715_ChIP-Seq_YYC3_Human1.52441419
83* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52000108
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51880882
85* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51851449
86* PIAS1_25552417_ChIP-Seq_VCAP_Human1.51783396
87RNF2_27304074_Chip-Seq_NSC_Mouse1.51749362
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51650519
89* FUS_26573619_Chip-Seq_HEK293_Human1.51568596
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51533393
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51362097
92REST_21632747_ChIP-Seq_MESCs_Mouse1.51204786
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50083698
94VDR_22108803_ChIP-Seq_LS180_Human1.48012005
95* CMYC_18555785_Chip-Seq_ESCs_Mouse1.47152999
96* STAT3_18555785_Chip-Seq_ESCs_Mouse1.45914825
97* EZH2_27294783_Chip-Seq_NPCs_Mouse1.45905634
98* ATF3_27146783_Chip-Seq_COLON_Human1.45368662
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44282624
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43648604
101ER_23166858_ChIP-Seq_MCF-7_Human1.42809457
102AR_21572438_ChIP-Seq_LNCaP_Human1.40496055
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39194177
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.38783329
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.37632371
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37239069
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36111412
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35741166
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35506246
110* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35460850
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34863730
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.34796084
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.32812448
114AR_25329375_ChIP-Seq_VCAP_Human1.32461798
115* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32376980
116* P300_18555785_Chip-Seq_ESCs_Mouse1.31855876
117CLOCK_20551151_ChIP-Seq_293T_Human1.30570467
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30434879
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27870048
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25301374
121SMC4_20622854_ChIP-Seq_HELA_Human1.25091980
122KDM2B_26808549_Chip-Seq_K562_Human1.25036496
123* PU1_27457419_Chip-Seq_LIVER_Mouse1.24840714
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24515799
125* OCT4_18555785_Chip-Seq_ESCs_Mouse1.23534991
126TP63_22573176_ChIP-Seq_HFKS_Human1.23333809
127SOX2_20726797_ChIP-Seq_SW620_Human1.22960289
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22845336
129TP53_22127205_ChIP-Seq_IMR90_Human1.22565113
130IRF8_22096565_ChIP-ChIP_GC-B_Human1.22248390
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22188164
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21988888
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21812313
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21512457
135CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21284465
136* RUNX2_22187159_ChIP-Seq_PCA_Human1.21036833
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20386312
138* CREB1_26743006_Chip-Seq_LNCaP_Human1.20161154
139* KDM2B_26808549_Chip-Seq_REH_Human1.19164726
140* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17668536
141TAL1_26923725_Chip-Seq_HPCs_Mouse1.17233289
142* ZFX_18555785_Chip-Seq_ESCs_Mouse1.16722215
143* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16609844
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15901761
145* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14998319
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14927218
147* KLF4_18555785_Chip-Seq_ESCs_Mouse1.14493278
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14277441
149STAT3_23295773_ChIP-Seq_U87_Human1.14044684
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14019179
151TCF4_23295773_ChIP-Seq_U87_Human1.13270804
152* CTCF_18555785_Chip-Seq_ESCs_Mouse1.13097151
153SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11672774
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09973727
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09952916
156JUN_21703547_ChIP-Seq_K562_Human1.09632693
157EWS_26573619_Chip-Seq_HEK293_Human1.09146889
158FOXO3_23340844_ChIP-Seq_DLD1_Human1.08572302
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07728100
160RXR_22158963_ChIP-Seq_LIVER_Mouse1.05123461
161AR_21909140_ChIP-Seq_LNCAP_Human1.03221129
162TP63_23658742_ChIP-Seq_EP156T_Human1.02373671
163NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02288701
164CJUN_26792858_Chip-Seq_BT549_Human1.02270377
165SA1_27219007_Chip-Seq_ERYTHROID_Human1.01430824
166CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00984781
167JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00399796
168PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98640732
169SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98600699
170TP53_23651856_ChIP-Seq_MEFs_Mouse0.97757800
171* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97059623
172CTCF_27219007_Chip-Seq_Bcells_Human0.96296192
173ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95882174
174TET1_21490601_ChIP-Seq_MESCs_Mouse0.95580330
175GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95086967
176KDM2B_26808549_Chip-Seq_DND41_Human0.94353300
177TCF7_22412390_ChIP-Seq_EML_Mouse0.94173644
178KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93723721
179ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93683376
180WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91858383
181CDX2_20551321_ChIP-Seq_CACO-2_Human0.91649527
182JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91519337
183TBX20_22328084_ChIP-Seq_HEART_Mouse0.91074241
184TBX20_22080862_ChIP-Seq_HEART_Mouse0.91074241
185* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90438756
186KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89786116
187TET1_21451524_ChIP-Seq_MESCs_Mouse0.88549192
188PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88013588
189RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87900412
190SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87882443
191AHR_22903824_ChIP-Seq_MCF-7_Human0.85893939
192EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85770827
193DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85403384
194* GATA6_25053715_ChIP-Seq_YYC3_Human0.84640963
195STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83458698
196ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83443109
197EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83232156
198PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81835545
199MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80536462
200DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79344649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.63319806
2MP0003880_abnormal_central_pattern4.00878550
3MP0004272_abnormal_basement_membrane3.92334417
4MP0010234_abnormal_vibrissa_follicle3.59016417
5MP0000566_synostosis3.26787007
6MP0003566_abnormal_cell_adhesion3.26168490
7MP0005623_abnormal_meninges_morphology3.11141258
8MP0005377_hearing/vestibular/ear_phenot3.09028230
9MP0003878_abnormal_ear_physiology3.09028230
10MP0006292_abnormal_olfactory_placode2.96897119
11MP0005257_abnormal_intraocular_pressure2.80686213
12MP0002163_abnormal_gland_morphology2.73378070
13MP0000569_abnormal_digit_pigmentation2.71528410
14MP0000537_abnormal_urethra_morphology2.70409249
15MP0002796_impaired_skin_barrier2.64329895
16MP0001188_hyperpigmentation2.55791513
17MP0003453_abnormal_keratinocyte_physiol2.52251685
18MP0005379_endocrine/exocrine_gland_phen2.47852847
19MP0005248_abnormal_Harderian_gland2.47099135
20MP0000762_abnormal_tongue_morphology2.46981329
21MP0002735_abnormal_chemical_nociception2.45911883
22MP0009053_abnormal_anal_canal2.45037816
23MP0003705_abnormal_hypodermis_morpholog2.40091181
24MP0005023_abnormal_wound_healing2.33411662
25MP0001849_ear_inflammation2.31151715
26MP0010678_abnormal_skin_adnexa2.30413289
27MP0002638_abnormal_pupillary_reflex2.26284581
28MP0002736_abnormal_nociception_after2.23738035
29MP0005645_abnormal_hypothalamus_physiol2.22695809
30MP0001968_abnormal_touch/_nociception2.22397108
31MP0002060_abnormal_skin_morphology2.22212178
32MP0005646_abnormal_pituitary_gland2.19621780
33MP0009745_abnormal_behavioral_response2.16387724
34MP0000467_abnormal_esophagus_morphology2.12274710
35MP0001486_abnormal_startle_reflex2.12072534
36MP0002277_abnormal_respiratory_mucosa2.07762452
37MP0003136_yellow_coat_color2.07282787
38MP0001216_abnormal_epidermal_layer2.07057848
39MP0009697_abnormal_copulation2.05980750
40MP0005171_absent_coat_pigmentation2.05291571
41MP0006276_abnormal_autonomic_nervous2.00857251
42MP0009046_muscle_twitch2.00586193
43MP0000383_abnormal_hair_follicle1.97165575
44MP0004859_abnormal_synaptic_plasticity1.96844895
45MP0001905_abnormal_dopamine_level1.94714437
46MP0001501_abnormal_sleep_pattern1.91490978
47MP0003635_abnormal_synaptic_transmissio1.89458215
48MP0001835_abnormal_antigen_presentation1.88778606
49MP0002572_abnormal_emotion/affect_behav1.85387545
50MP0001984_abnormal_olfaction1.85334892
51MP0002877_abnormal_melanocyte_morpholog1.85072441
52MP0005076_abnormal_cell_differentiation1.83777882
53MP0010352_gastrointestinal_tract_polyps1.81562040
54MP0005501_abnormal_skin_physiology1.80643306
55MP0003091_abnormal_cell_migration1.77445162
56MP0002148_abnormal_hypersensitivity_rea1.77209764
57MP0005423_abnormal_somatic_nervous1.75363892
58MP0010386_abnormal_urinary_bladder1.74784622
59MP0002063_abnormal_learning/memory/cond1.72190746
60MP0008875_abnormal_xenobiotic_pharmacok1.71907794
61MP0002064_seizures1.70191955
62MP0005409_darkened_coat_color1.69988495
63MP0001440_abnormal_grooming_behavior1.68597016
64MP0002098_abnormal_vibrissa_morphology1.67786455
65MP0004264_abnormal_extraembryonic_tissu1.65929155
66MP0001529_abnormal_vocalization1.64898719
67MP0001986_abnormal_taste_sensitivity1.57042995
68MP0000015_abnormal_ear_pigmentation1.51587515
69MP0010771_integument_phenotype1.51458692
70MP0004742_abnormal_vestibular_system1.48245667
71MP0001502_abnormal_circadian_rhythm1.46934908
72MP0000465_gastrointestinal_hemorrhage1.46907390
73MP0009785_altered_susceptibility_to1.46634567
74MP0002557_abnormal_social/conspecific_i1.45661751
75MP0001346_abnormal_lacrimal_gland1.44119813
76MP0002132_abnormal_respiratory_system1.42168889
77MP0008004_abnormal_stomach_pH1.41450965
78MP0002067_abnormal_sensory_capabilities1.40902894
79MP0003315_abnormal_perineum_morphology1.39979622
80MP0002876_abnormal_thyroid_physiology1.39562948
81MP0004858_abnormal_nervous_system1.39463539
82MP0004233_abnormal_muscle_weight1.39274201
83MP0002272_abnormal_nervous_system1.36383826
84MP0003300_gastrointestinal_ulcer1.34488789
85MP0001879_abnormal_lymphatic_vessel1.32877953
86MP0006138_congestive_heart_failure1.31385350
87MP0000627_abnormal_mammary_gland1.30160419
88MP0002734_abnormal_mechanical_nocicepti1.30065510
89MP0002102_abnormal_ear_morphology1.28419518
90MP0005671_abnormal_response_to1.28264507
91MP0002419_abnormal_innate_immunity1.26694613
92MP0003329_amyloid_beta_deposits1.26351542
93MP0000858_altered_metastatic_potential1.25313174
94MP0005551_abnormal_eye_electrophysiolog1.24057127
95MP0005083_abnormal_biliary_tract1.23989295
96MP0006082_CNS_inflammation1.22398086
97MP0001970_abnormal_pain_threshold1.21763357
98MP0003787_abnormal_imprinting1.21670835
99MP0001790_abnormal_immune_system1.21494942
100MP0005387_immune_system_phenotype1.21494942
101MP0001963_abnormal_hearing_physiology1.21268291
102MP0004947_skin_inflammation1.21266838
103MP0005310_abnormal_salivary_gland1.20461099
104MP0005165_increased_susceptibility_to1.18845693
105MP0004782_abnormal_surfactant_physiolog1.17547751
106MP0005275_abnormal_skin_tensile1.16814413
107MP0005174_abnormal_tail_pigmentation1.15978114
108MP0003879_abnormal_hair_cell1.15961038
109MP0005000_abnormal_immune_tolerance1.15423696
110MP0010030_abnormal_orbit_morphology1.14489668
111MP0002938_white_spotting1.14054462
112MP0005164_abnormal_response_to1.13430029
113MP0000733_abnormal_muscle_development1.12581219
114MP0002184_abnormal_innervation1.11248345
115MP0000778_abnormal_nervous_system1.10733327
116MP0003724_increased_susceptibility_to1.09840869
117MP0009764_decreased_sensitivity_to1.09254309
118MP0001485_abnormal_pinna_reflex1.07804891
119MP0005193_abnormal_anterior_eye1.07721100
120MP0010368_abnormal_lymphatic_system1.07396732
121MP0000377_abnormal_hair_follicle1.06795076
122MP0000631_abnormal_neuroendocrine_gland1.06007529
123MP0000372_irregular_coat_pigmentation1.04247117
124MP0005386_behavior/neurological_phenoty1.03887943
125MP0004924_abnormal_behavior1.03887943
126MP0000026_abnormal_inner_ear1.02220983
127MP0001873_stomach_inflammation1.00855204
128MP0003943_abnormal_hepatobiliary_system0.99174028
129MP0004381_abnormal_hair_follicle0.99136787
130MP0002089_abnormal_postnatal_growth/wei0.98165371
131MP0000490_abnormal_crypts_of0.96664646
132MP0005197_abnormal_uvea_morphology0.96334115
133MP0009931_abnormal_skin_appearance0.94967510
134MP0000681_abnormal_thyroid_gland0.93817313
135MP0003122_maternal_imprinting0.92913884
136MP0004019_abnormal_vitamin_homeostasis0.92770607
137MP0005253_abnormal_eye_physiology0.92437673
138MP0002139_abnormal_hepatobiliary_system0.91865062
139MP0003828_pulmonary_edema0.91162377
140MP0005025_abnormal_response_to0.91068137
141MP0001661_extended_life_span0.91032597
142MP0002733_abnormal_thermal_nociception0.88280998
143MP0003075_altered_response_to0.85478048
144MP0002998_abnormal_bone_remodeling0.83919134
145MP0001664_abnormal_digestion0.83355904
146MP0003941_abnormal_skin_development0.82278155
147MP0003436_decreased_susceptibility_to0.82096987
148MP0003191_abnormal_cellular_cholesterol0.81757032
149MP0004885_abnormal_endolymph0.81061020
150MP0004270_analgesia0.79091636
151MP0003950_abnormal_plasma_membrane0.76931494
152MP0004142_abnormal_muscle_tone0.76182367
153MP0002723_abnormal_immune_serum0.76117353
154MP0002697_abnormal_eye_size0.75828656
155MP0004185_abnormal_adipocyte_glucose0.75741509
156MP0002452_abnormal_antigen_presenting0.75585353
157MP0003172_abnormal_lysosome_physiology0.75392117
158MP0009780_abnormal_chondrocyte_physiolo0.75327282
159MP0002332_abnormal_exercise_endurance0.75266635
160MP0005670_abnormal_white_adipose0.74304219
161MP0000678_abnormal_parathyroid_gland0.73945604
162MP0008260_abnormal_autophagy0.72313230
163MP0001340_abnormal_eyelid_morphology0.71691248
164MP0001348_abnormal_lacrimal_gland0.71456524
165MP0002234_abnormal_pharynx_morphology0.71434886
166MP0000538_abnormal_urinary_bladder0.71400118
167MP0001186_pigmentation_phenotype0.71049032
168MP0005621_abnormal_cell_physiology0.70427642
169MP0002168_other_aberrant_phenotype0.69965664
170MP0000367_abnormal_coat/_hair0.68986443
171MP0000920_abnormal_myelination0.68050069
172MP0005451_abnormal_body_composition0.67202565
173MP0001915_intracranial_hemorrhage0.66968003
174MP0001819_abnormal_immune_cell0.66353851
175MP0003045_fibrosis0.65597387
176* MP0002066_abnormal_motor_capabilities/c0.65437352
177MP0002882_abnormal_neuron_morphology0.63465310
178MP0003115_abnormal_respiratory_system0.63263682
179MP0000462_abnormal_digestive_system0.62682000
180MP0002896_abnormal_bone_mineralization0.62559651
181MP0002420_abnormal_adaptive_immunity0.62336274
182MP0004510_myositis0.59214291
183MP0002925_abnormal_cardiovascular_devel0.58325995
184MP0001851_eye_inflammation0.58275694
185MP0001614_abnormal_blood_vessel0.58176047
186MP0002282_abnormal_trachea_morphology0.57210675
187MP0000613_abnormal_salivary_gland0.56834371
188MP0005508_abnormal_skeleton_morphology0.55732464
189MP0003634_abnormal_glial_cell0.55029842

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)5.11491354
2Onycholysis (HP:0001806)5.00394377
3Milia (HP:0001056)4.98489578
4Parakeratosis (HP:0001036)4.72392691
5Nonprogressive disorder (HP:0003680)4.38346941
6Atrophic scars (HP:0001075)4.20824581
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.18763409
8Focal motor seizures (HP:0011153)3.80557278
9Plantar hyperkeratosis (HP:0007556)3.79894504
10Arterial tortuosity (HP:0005116)3.71733589
11Pili torti (HP:0003777)3.68616903
12Febrile seizures (HP:0002373)3.58903151
13Selective tooth agenesis (HP:0001592)3.57638275
14Abnormal respiratory motile cilium physiology (HP:0012261)3.56280745
15Neurofibrillary tangles (HP:0002185)3.31931727
16Broad face (HP:0000283)3.29493224
17Aplasia involving bones of the extremities (HP:0009825)3.26833387
18Aplasia involving bones of the upper limbs (HP:0009823)3.26833387
19Aplasia of the phalanges of the hand (HP:0009802)3.26833387
20Congenital sensorineural hearing impairment (HP:0008527)3.24729506
21Recurrent abscess formation (HP:0002722)3.21494471
22White forelock (HP:0002211)3.20860617
23Nail dystrophy (HP:0008404)3.15353124
24Pterygium (HP:0001059)3.11824465
25Rhinitis (HP:0012384)3.11256055
26Epileptic encephalopathy (HP:0200134)3.10105654
27Nasolacrimal duct obstruction (HP:0000579)3.07150894
28Patchy hypopigmentation of hair (HP:0011365)3.05911360
29Chronic bronchitis (HP:0004469)3.01967722
30Septo-optic dysplasia (HP:0100842)3.01662167
31Hypoplasia of dental enamel (HP:0006297)2.99467540
32Vascular tortuosity (HP:0004948)2.98860554
33Increased IgM level (HP:0003496)2.97082321
34Hyperventilation (HP:0002883)2.91781081
35Osteomalacia (HP:0002749)2.89781265
36Eczematoid dermatitis (HP:0000976)2.89767675
37Cerebral inclusion bodies (HP:0100314)2.88680068
38Ulnar bowing (HP:0003031)2.82616601
39Abnormal hair laboratory examination (HP:0003328)2.82528053
40Short nail (HP:0001799)2.82511096
41Alopecia of scalp (HP:0002293)2.80799390
42Cheilitis (HP:0100825)2.76166789
43Ankyloglossia (HP:0010296)2.74710756
44Abnormal hair whorl (HP:0010721)2.73373110
45Recurrent bacterial skin infections (HP:0005406)2.73199562
46Abnormality of oral frenula (HP:0000190)2.72069568
47Thick nail (HP:0001805)2.69860844
48Corneal erosion (HP:0200020)2.62993759
49Medial flaring of the eyebrow (HP:0010747)2.61059522
50Optic neuritis (HP:0100653)2.60255527
51Retrobulbar optic neuritis (HP:0100654)2.60255527
52Ridged nail (HP:0001807)2.60092730
53Mediastinal lymphadenopathy (HP:0100721)2.58565410
54Obstructive lung disease (HP:0006536)2.57810400
55Chronic obstructive pulmonary disease (HP:0006510)2.57810400
56Abnormality of the distal phalanges of the toes (HP:0010182)2.56305003
57Nephrogenic diabetes insipidus (HP:0009806)2.55198267
58Fragile skin (HP:0001030)2.53983537
59Distal lower limb amyotrophy (HP:0008944)2.53833999
60Absent/shortened dynein arms (HP:0200106)2.53529716
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.53529716
62Abnormality of renal resorption (HP:0011038)2.52544220
63Prostate neoplasm (HP:0100787)2.50768155
64Absent eyebrow (HP:0002223)2.49709112
65Nasal polyposis (HP:0100582)2.48360943
66Decreased central vision (HP:0007663)2.47285068
67Limb dystonia (HP:0002451)2.45093883
68Vascular calcification (HP:0004934)2.44980318
69Hypoplasia of the fovea (HP:0007750)2.44100436
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.44100436
71Abnormality of nail color (HP:0100643)2.43999475
72Corneal dystrophy (HP:0001131)2.43680478
73Right ventricular cardiomyopathy (HP:0011663)2.43185572
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.40402335
75Osteolytic defects of the hand bones (HP:0009699)2.40402335
76Lower limb amyotrophy (HP:0007210)2.40044910
77Recurrent pneumonia (HP:0006532)2.38017483
78Tubulointerstitial nephritis (HP:0001970)2.37136670
79Hypotrichosis (HP:0001006)2.36900422
80Conical tooth (HP:0000698)2.32565265
81Distal lower limb muscle weakness (HP:0009053)2.32189739
82Abnormality of the lacrimal duct (HP:0011481)2.25796185
83Abnormality of incisor morphology (HP:0011063)2.25363030
84Interstitial pulmonary disease (HP:0006530)2.25098655
85Abnormality of the salivary glands (HP:0010286)2.24517217
86Gait imbalance (HP:0002141)2.23722121
87Hyperphosphatemia (HP:0002905)2.22703190
88Absent septum pellucidum (HP:0001331)2.20540456
89Decreased circulating renin level (HP:0003351)2.20455457
90Hypoplastic labia majora (HP:0000059)2.19105895
91Chronic hepatic failure (HP:0100626)2.18243372
92Hip dysplasia (HP:0001385)2.17971319
93Fair hair (HP:0002286)2.17453842
94Recurrent gram-negative bacterial infections (HP:0005420)2.17019176
95True hermaphroditism (HP:0010459)2.16269275
96Fetal akinesia sequence (HP:0001989)2.16178935
97Focal segmental glomerulosclerosis (HP:0000097)2.15705655
98Abnormal blistering of the skin (HP:0008066)2.15604445
99Congenital primary aphakia (HP:0007707)2.14590513
100Bronchiectasis (HP:0002110)2.14562230
101Bowing of the arm (HP:0006488)2.12422651
102Bowed forearm bones (HP:0003956)2.12422651
1033-Methylglutaconic aciduria (HP:0003535)2.11491401
104Cardiovascular calcification (HP:0011915)2.11016678
105Recurrent corneal erosions (HP:0000495)2.10401370
106Nephritis (HP:0000123)2.09995894
107Pancreatic fibrosis (HP:0100732)2.09385742
108Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08624693
109Gingivitis (HP:0000230)2.08442029
110Palmoplantar hyperkeratosis (HP:0000972)2.06701413
111Amelogenesis imperfecta (HP:0000705)2.06563099
112Atonic seizures (HP:0010819)2.06006469
113Flattened epiphyses (HP:0003071)2.05304990
114Hypothermia (HP:0002045)2.04257040
115Coxa vara (HP:0002812)2.03944245
116Abnormal ciliary motility (HP:0012262)2.03278086
117Akinesia (HP:0002304)2.01799577
118Abnormality of molar (HP:0011077)2.01423165
119Abnormality of molar morphology (HP:0011070)2.01423165
120Blue irides (HP:0000635)2.01174223
121Radial bowing (HP:0002986)2.01019767
122Supranuclear gaze palsy (HP:0000605)2.00794034
123Absent speech (HP:0001344)1.99910518
124Trismus (HP:0000211)1.97686578
125Bronchomalacia (HP:0002780)1.97360293
126Renal Fanconi syndrome (HP:0001994)1.97128714
127Recurrent cutaneous fungal infections (HP:0011370)1.96392949
128Chronic mucocutaneous candidiasis (HP:0002728)1.96392949
129Small epiphyses (HP:0010585)1.95816477
130Chorioretinal atrophy (HP:0000533)1.95762759
131Abnormality of the dental root (HP:0006486)1.95087139
132Taurodontia (HP:0000679)1.95087139
133Abnormality of permanent molar morphology (HP:0011071)1.95087139
134Genital tract atresia (HP:0001827)1.94822323
135Congenital stationary night blindness (HP:0007642)1.94030913
136Abnormality of the fovea (HP:0000493)1.93800523
137Sparse eyelashes (HP:0000653)1.93729374
138Recurrent skin infections (HP:0001581)1.93043719
139Occipital encephalocele (HP:0002085)1.92607542
140Orchitis (HP:0100796)1.92389002
141Abnormality of the labia majora (HP:0012881)1.92067542
142Optic nerve hypoplasia (HP:0000609)1.92056949
143Conjugated hyperbilirubinemia (HP:0002908)1.90810943
144Spinal cord compression (HP:0002176)1.90801774
145Obstructive sleep apnea (HP:0002870)1.90077039
146Abnormality of the nasal mucosa (HP:0000433)1.89762446
147Dyschromatopsia (HP:0007641)1.88712848
148Vaginal atresia (HP:0000148)1.88618087
149Protruding tongue (HP:0010808)1.87843956
150Abnormality of the septum pellucidum (HP:0007375)1.87705386
151Broad-based gait (HP:0002136)1.87543904
152Follicular hyperkeratosis (HP:0007502)1.86773452
153Generalized hypopigmentation of hair (HP:0011358)1.86284173
154Abnormality of calcium-phosphate metabolism (HP:0100530)1.86263739
155Abnormal ossification of hand bones (HP:0005921)1.85149541
156Premature rupture of membranes (HP:0001788)1.84754060
157Segmental peripheral demyelination/remyelination (HP:0003481)1.84228848
158Abnormality of macrophages (HP:0004311)1.84028929
159Abnormality of the nasolacrimal system (HP:0000614)1.83685387
160Synostosis involving the elbow (HP:0003938)1.82884845
161Humeroradial synostosis (HP:0003041)1.82884845
162Protrusio acetabuli (HP:0003179)1.82319387
163Flat acetabular roof (HP:0003180)1.82308487
164Abnormal respiratory epithelium morphology (HP:0012253)1.81008674
165Abnormal respiratory motile cilium morphology (HP:0005938)1.81008674
166Abnormality of the dental pulp (HP:0006479)1.80763921
167Palmar hyperkeratosis (HP:0010765)1.80417203
168Hyperactive renin-angiotensin system (HP:0000841)1.79770241
169Mitral stenosis (HP:0001718)1.79160388
170Bilateral sensorineural hearing impairment (HP:0008619)1.78190675
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.77575196
172Hyperaldosteronism (HP:0000859)1.77135252
173Aplasia cutis congenita (HP:0001057)1.76632929
174Relative macrocephaly (HP:0004482)1.76612433
175Alveolar cell carcinoma (HP:0006519)1.76335212
176Stomatitis (HP:0010280)1.75670572
177Abnormality of dental color (HP:0011073)1.75632183
178Anomalous pulmonary venous return (HP:0010772)1.74520407
179J-shaped sella turcica (HP:0002680)1.72284280
180Large eyes (HP:0001090)1.71849266
181Popliteal pterygium (HP:0009756)1.71026944
182Unilateral renal agenesis (HP:0000122)1.69683242
183Vasculitis (HP:0002633)1.68838342
184Generalized tonic-clonic seizures (HP:0002069)1.68740941
185Abnormality of the prostate (HP:0008775)1.68164720
186Abnormal rod and cone electroretinograms (HP:0008323)1.66576611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.73255519
2EPHA24.70625072
3CASK4.33486144
4PRPF4B3.04458054
5MET3.00472792
6SIK32.99283669
7EPHA42.98716926
8RIPK42.96589415
9LATS12.95289572
10MAP2K72.94480571
11MAP3K22.73340317
12MAP3K122.64727509
13MAP3K92.61278310
14TNIK2.59161143
15NTRK12.57697642
16EPHB22.49496390
17ADRBK22.47885597
18MAP3K142.42450903
19EPHB12.40420813
20TRIB32.30685812
21TXK2.23899781
22MAP3K32.14543615
23IRAK42.05963583
24BMPR22.04445220
25NTRK32.01783839
26IRAK31.99311836
27SIK21.92472226
28INSRR1.83616027
29ICK1.79777280
30TTN1.78978833
31BMPR1B1.69655887
32STK101.69513542
33YES11.66224781
34MOS1.55670531
35PLK21.51717299
36PTK21.50068725
37ZAK1.43268672
38ERN11.42013764
39MAP3K41.40592411
40RIPK11.39244677
41PAK41.36201248
42GRK71.35205317
43TESK11.32692941
44FGR1.32523180
45EIF2AK21.27913978
46ERBB41.22641024
47MARK11.21689295
48LATS21.20935226
49SIK11.20403546
50PBK1.19279481
51BLK1.16578399
52MAP3K131.14439283
53CDK121.12247146
54SMG11.11713312
55SGK21.10533983
56PKN21.10259302
57BMX1.07818952
58GRK51.04760711
59MAPK131.02238703
60MUSK1.01793175
61NEK60.98286498
62CDK30.97901779
63AKT30.97241874
64IRAK20.95543668
65FES0.92789486
66LYN0.91019623
67MAP3K110.90991075
68PRKD30.90568118
69CDK80.89380258
70PAK20.87756151
71TRPM70.87069997
72CAMK1D0.85870561
73MTOR0.85732919
74ERBB30.85503548
75TSSK60.83201253
76IKBKB0.82762640
77TAOK10.81465038
78TAOK20.81387961
79EIF2AK10.81143732
80CAMK2A0.80223963
81BRAF0.79655049
82PRKCE0.79155504
83BCR0.78557670
84NME20.77878148
85MARK20.77538593
86TGFBR10.77475139
87SYK0.77044039
88MELK0.76754545
89MAP3K10.76515859
90PINK10.76501319
91TEC0.75312686
92PIM20.74970554
93CAMKK10.73802415
94SGK2230.73718872
95SGK4940.73718872
96TNK20.73711471
97MAP2K10.73056189
98NTRK20.72482821
99NME10.71571037
100CAMK1G0.71376853
101MKNK20.70849294
102PNCK0.70770252
103IRAK10.70712629
104RPS6KA40.69867855
105TGFBR20.68274420
106CHUK0.68017311
107GRK10.66280860
108MAP2K40.66016778
109PRKCI0.65485372
110MST40.64792427
111IKBKE0.62240500
112PDGFRA0.61873407
113HCK0.61473352
114STK160.61073409
115PKN10.60749561
116FLT30.60394362
117AURKA0.60107226
118DYRK1A0.59670314
119OXSR10.58969922
120KSR20.58452568
121MAPK150.57456662
122PRKCQ0.57237700
123PTK2B0.57041308
124PHKG10.54598199
125PHKG20.54598199
126MINK10.53370922
127PRKCG0.53030785
128MAPK70.51632054
129CAMK2B0.50658563
130LIMK10.48925318
131MAP3K80.48853281
132SGK10.48631508
133EPHA30.48524116
134JAK30.47582535
135CDK50.47111792
136SGK30.46174968
137CDK190.45878132
138ROCK20.45575014
139PRKD20.45349899
140CLK10.44794436
141MAPKAPK50.44530512
142LMTK20.44165413
143ABL20.43908002
144PDPK10.43627599
145FER0.43504558
146LCK0.42974694
147LRRK20.42955602
148RET0.42561533
149ILK0.42350482
150STK380.42245753
151PRKCD0.41899154
152MARK30.40211891
153FYN0.39521176
154ARAF0.39506977
155CAMK10.38983917
156MAP3K70.38738855
157PRKG10.38661334
158CDK90.38447285
159JAK10.38287700
160RPS6KA20.38093758
161NUAK10.37709465
162ADRBK10.37478212
163FGFR40.37219847
164PAK10.36781717
165VRK10.36766566
166TBK10.36481326
167KIT0.36121829
168CSK0.35733952
169PDGFRB0.34835603
170PRKACA0.34770923
171PRKCA0.33601613
172MYLK0.32712115
173ABL10.32158285
174KSR10.31902397
175PTK60.31762182
176RPS6KB20.31207980
177WNK30.30330450
178DAPK10.29731668
179BTK0.29619820
180CAMK2D0.28409945
181RPS6KA60.28239850
182PASK0.27525062
183MAP2K20.27399895
184HIPK20.26042274

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88389538
2ECM-receptor interaction_Homo sapiens_hsa045123.29375499
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.25665918
4Small cell lung cancer_Homo sapiens_hsa052222.99325347
5Graft-versus-host disease_Homo sapiens_hsa053322.44750483
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.37715362
7* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.33622256
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18612767
9Rheumatoid arthritis_Homo sapiens_hsa053232.16005824
10Amoebiasis_Homo sapiens_hsa051462.14057483
11Morphine addiction_Homo sapiens_hsa050322.12303423
12Synaptic vesicle cycle_Homo sapiens_hsa047212.01102463
13Focal adhesion_Homo sapiens_hsa045102.00756458
14Allograft rejection_Homo sapiens_hsa053301.99574475
15Serotonergic synapse_Homo sapiens_hsa047261.92687568
16Type I diabetes mellitus_Homo sapiens_hsa049401.90279178
17African trypanosomiasis_Homo sapiens_hsa051431.90263575
18Collecting duct acid secretion_Homo sapiens_hsa049661.87926750
19Taste transduction_Homo sapiens_hsa047421.83677393
20GABAergic synapse_Homo sapiens_hsa047271.79377771
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78730525
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77297635
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72721617
24Pancreatic cancer_Homo sapiens_hsa052121.70314077
25Autoimmune thyroid disease_Homo sapiens_hsa053201.66852510
26Phenylalanine metabolism_Homo sapiens_hsa003601.66009560
27Glutamatergic synapse_Homo sapiens_hsa047241.64159184
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63442213
29Adherens junction_Homo sapiens_hsa045201.62902638
30Bladder cancer_Homo sapiens_hsa052191.62233602
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56329506
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54531411
33Circadian entrainment_Homo sapiens_hsa047131.53921886
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.52036570
35Histidine metabolism_Homo sapiens_hsa003401.50521634
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50090612
37Chronic myeloid leukemia_Homo sapiens_hsa052201.47834480
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47813150
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46614679
40N-Glycan biosynthesis_Homo sapiens_hsa005101.44793478
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40575910
42Oxidative phosphorylation_Homo sapiens_hsa001901.39637755
43Proteoglycans in cancer_Homo sapiens_hsa052051.37937745
44Phagosome_Homo sapiens_hsa041451.37745033
45Amphetamine addiction_Homo sapiens_hsa050311.33346617
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32661761
47Renal cell carcinoma_Homo sapiens_hsa052111.32559739
48Olfactory transduction_Homo sapiens_hsa047401.32087926
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.28726921
50Cocaine addiction_Homo sapiens_hsa050301.28449046
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27827606
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.24629055
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24308061
54Calcium signaling pathway_Homo sapiens_hsa040201.23770319
55Leishmaniasis_Homo sapiens_hsa051401.23562952
56Fructose and mannose metabolism_Homo sapiens_hsa000511.19530734
57Notch signaling pathway_Homo sapiens_hsa043301.17977986
58Hippo signaling pathway_Homo sapiens_hsa043901.17636893
59Galactose metabolism_Homo sapiens_hsa000521.16222619
60Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14964792
61Hematopoietic cell lineage_Homo sapiens_hsa046401.13569015
62Malaria_Homo sapiens_hsa051441.13306964
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11614544
64Tight junction_Homo sapiens_hsa045301.09604607
65Sphingolipid metabolism_Homo sapiens_hsa006001.08299532
66Caffeine metabolism_Homo sapiens_hsa002321.08264622
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08132088
68Phototransduction_Homo sapiens_hsa047441.07900392
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07198012
70NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06597869
71Tuberculosis_Homo sapiens_hsa051521.05368357
72Fatty acid biosynthesis_Homo sapiens_hsa000611.05298142
73Salmonella infection_Homo sapiens_hsa051321.05024400
74Pentose phosphate pathway_Homo sapiens_hsa000301.04106422
75Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03982530
76Pathways in cancer_Homo sapiens_hsa052001.03602679
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03094953
78Vibrio cholerae infection_Homo sapiens_hsa051101.02549669
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01192553
80Prostate cancer_Homo sapiens_hsa052151.00841785
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99874489
82Salivary secretion_Homo sapiens_hsa049700.99851173
83Cholinergic synapse_Homo sapiens_hsa047250.99487895
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.99344691
85Alzheimers disease_Homo sapiens_hsa050100.98827770
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98748953
87Measles_Homo sapiens_hsa051620.98347330
88Insulin secretion_Homo sapiens_hsa049110.96248551
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.95521873
90Mineral absorption_Homo sapiens_hsa049780.95461431
91Glioma_Homo sapiens_hsa052140.94813896
92Dopaminergic synapse_Homo sapiens_hsa047280.94725542
93Ether lipid metabolism_Homo sapiens_hsa005650.93489938
94Starch and sucrose metabolism_Homo sapiens_hsa005000.91920837
95Renin secretion_Homo sapiens_hsa049240.91463568
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91254900
97Steroid biosynthesis_Homo sapiens_hsa001000.91101451
98Acute myeloid leukemia_Homo sapiens_hsa052210.90901335
99Chemical carcinogenesis_Homo sapiens_hsa052040.90406615
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.90277844
101Bile secretion_Homo sapiens_hsa049760.89934199
102Non-small cell lung cancer_Homo sapiens_hsa052230.89846263
103Asthma_Homo sapiens_hsa053100.89512796
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89176602
105Tyrosine metabolism_Homo sapiens_hsa003500.87951968
106MicroRNAs in cancer_Homo sapiens_hsa052060.87594924
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86983306
108Prion diseases_Homo sapiens_hsa050200.86144242
109Shigellosis_Homo sapiens_hsa051310.85496605
110Melanoma_Homo sapiens_hsa052180.85110948
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84923492
112Retinol metabolism_Homo sapiens_hsa008300.84290865
113Legionellosis_Homo sapiens_hsa051340.82774645
114Long-term depression_Homo sapiens_hsa047300.82714667
115Dilated cardiomyopathy_Homo sapiens_hsa054140.82293421
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81879335
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81637544
118Axon guidance_Homo sapiens_hsa043600.81502624
119beta-Alanine metabolism_Homo sapiens_hsa004100.80544854
120Osteoclast differentiation_Homo sapiens_hsa043800.80372362
121TNF signaling pathway_Homo sapiens_hsa046680.79830092
122ABC transporters_Homo sapiens_hsa020100.79792824
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79209097
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78823656
125Chemokine signaling pathway_Homo sapiens_hsa040620.78755039
126VEGF signaling pathway_Homo sapiens_hsa043700.77985687
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77939903
128Apoptosis_Homo sapiens_hsa042100.77597300
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76600928
130Rap1 signaling pathway_Homo sapiens_hsa040150.76430908
131Pertussis_Homo sapiens_hsa051330.75930395
132Primary immunodeficiency_Homo sapiens_hsa053400.74857396
133Lysosome_Homo sapiens_hsa041420.71021597
134Long-term potentiation_Homo sapiens_hsa047200.70970614
135Circadian rhythm_Homo sapiens_hsa047100.70463182
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69984329
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.69732027
138Parkinsons disease_Homo sapiens_hsa050120.69380551
139Thyroid cancer_Homo sapiens_hsa052160.69250154
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67450890
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66946848
142Endocytosis_Homo sapiens_hsa041440.66844530
143Regulation of autophagy_Homo sapiens_hsa041400.65395248
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65180134
145Ovarian steroidogenesis_Homo sapiens_hsa049130.63596019
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63206049
147cAMP signaling pathway_Homo sapiens_hsa040240.62520530
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62057103
149Toxoplasmosis_Homo sapiens_hsa051450.62027767
150Staphylococcus aureus infection_Homo sapiens_hsa051500.61540978
151HIF-1 signaling pathway_Homo sapiens_hsa040660.60483238
152Arachidonic acid metabolism_Homo sapiens_hsa005900.60352979
153Type II diabetes mellitus_Homo sapiens_hsa049300.59834239
154Choline metabolism in cancer_Homo sapiens_hsa052310.58606426
155Influenza A_Homo sapiens_hsa051640.58490460
156Glutathione metabolism_Homo sapiens_hsa004800.56041882
157GnRH signaling pathway_Homo sapiens_hsa049120.55989694
158Vitamin digestion and absorption_Homo sapiens_hsa049770.55828113
159Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54783973
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53477548
161Biosynthesis of amino acids_Homo sapiens_hsa012300.52531957
162Complement and coagulation cascades_Homo sapiens_hsa046100.51619559
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50353099
164Other glycan degradation_Homo sapiens_hsa005110.49663603
165Hepatitis C_Homo sapiens_hsa051600.49019384
166Oxytocin signaling pathway_Homo sapiens_hsa049210.48285471
167Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48065169
168Gap junction_Homo sapiens_hsa045400.47940020
169Fatty acid elongation_Homo sapiens_hsa000620.47450715
170Ras signaling pathway_Homo sapiens_hsa040140.47049705
171p53 signaling pathway_Homo sapiens_hsa041150.45231847
172Insulin signaling pathway_Homo sapiens_hsa049100.44927325
173Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43859716
174ErbB signaling pathway_Homo sapiens_hsa040120.43427355
175Vitamin B6 metabolism_Homo sapiens_hsa007500.41909016
176Adipocytokine signaling pathway_Homo sapiens_hsa049200.41347798
177Gastric acid secretion_Homo sapiens_hsa049710.40923701
178Huntingtons disease_Homo sapiens_hsa050160.40695239
179Herpes simplex infection_Homo sapiens_hsa051680.40126790
180Steroid hormone biosynthesis_Homo sapiens_hsa001400.39752374
181Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39174342
182Endometrial cancer_Homo sapiens_hsa052130.38993306
183Insulin resistance_Homo sapiens_hsa049310.38549044
184Vascular smooth muscle contraction_Homo sapiens_hsa042700.38229005
185Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38137911
186MAPK signaling pathway_Homo sapiens_hsa040100.36583617

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