NPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.43901156
2glycosphingolipid catabolic process (GO:0046479)5.34845125
3oligosaccharide catabolic process (GO:0009313)5.33475363
4surfactant homeostasis (GO:0043129)4.97516449
5glycolipid catabolic process (GO:0019377)4.81991403
6amino sugar catabolic process (GO:0046348)4.70133810
7negative regulation of interleukin-12 production (GO:0032695)4.65031708
8adhesion of symbiont to host cell (GO:0044650)4.37250071
9virion attachment to host cell (GO:0019062)4.37250071
10ceramide catabolic process (GO:0046514)4.26354800
11response to lipoprotein particle (GO:0055094)3.97944094
12membrane lipid catabolic process (GO:0046466)3.95189618
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90633008
14antigen processing and presentation of endogenous antigen (GO:0019883)3.86106062
15sphingolipid catabolic process (GO:0030149)3.84803771
16negative regulation of nitric oxide biosynthetic process (GO:0045019)3.83415357
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.82875673
18modulation by symbiont of host immune response (GO:0052553)3.82875673
19positive regulation by symbiont of host defense response (GO:0052509)3.82875673
20modulation by symbiont of host defense response (GO:0052031)3.82875673
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.82875673
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.82875673
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81097832
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81097832
25amyloid precursor protein catabolic process (GO:0042987)3.73660010
26regulation of podosome assembly (GO:0071801)3.73058353
27response to thyroid hormone (GO:0097066)3.72483731
28central nervous system myelination (GO:0022010)3.62745668
29axon ensheathment in central nervous system (GO:0032291)3.62745668
30neutrophil activation (GO:0042119)3.52400400
31keratan sulfate catabolic process (GO:0042340)3.51800686
32regulation of vitamin D biosynthetic process (GO:0060556)3.50682888
33regulation of cytokine secretion involved in immune response (GO:0002739)3.50561610
34adhesion of symbiont to host (GO:0044406)3.49859116
35positive regulation of antigen processing and presentation (GO:0002579)3.49723128
36amyloid precursor protein metabolic process (GO:0042982)3.48693552
37granulocyte activation (GO:0036230)3.46316905
38positive regulation of chemokine biosynthetic process (GO:0045080)3.43719459
39fatty acid elongation (GO:0030497)3.41931791
40regulation of macrophage chemotaxis (GO:0010758)3.41302827
41N-acetylneuraminate metabolic process (GO:0006054)3.39790110
42respiratory burst (GO:0045730)3.39785977
43barbed-end actin filament capping (GO:0051016)3.37772477
44chemical homeostasis within a tissue (GO:0048875)3.37414157
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32367520
46positive regulation of interferon-alpha production (GO:0032727)3.31962313
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.28744500
48regulation of antigen processing and presentation (GO:0002577)3.27527984
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.23650785
50positive regulation of mast cell degranulation (GO:0043306)3.23650785
51regulation of interferon-beta biosynthetic process (GO:0045357)3.22158067
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20752633
53regulation of membrane protein ectodomain proteolysis (GO:0051043)3.19986408
54negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.17325015
55phagosome maturation (GO:0090382)3.14518331
56regulation of cholesterol storage (GO:0010885)3.13637042
57regulation of interferon-alpha production (GO:0032647)3.13186412
58T-helper 1 type immune response (GO:0042088)3.11839347
59positive regulation of monocyte chemotaxis (GO:0090026)3.08450943
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.06830387
61regulation of superoxide anion generation (GO:0032928)3.05202640
62regulation of mast cell degranulation (GO:0043304)3.04094559
63positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.02188656
64regulation of chemokine biosynthetic process (GO:0045073)3.02019245
65detection of molecule of bacterial origin (GO:0032490)3.02004852
66positive regulation of mast cell activation (GO:0033005)3.00368980
67interferon-gamma-mediated signaling pathway (GO:0060333)2.99853586
68macrophage activation involved in immune response (GO:0002281)2.97387084
69negative regulation of cytokine production involved in immune response (GO:0002719)2.96951087
70positive regulation of interleukin-17 production (GO:0032740)2.96656688
71immunoglobulin mediated immune response (GO:0016064)2.96566216
72low-density lipoprotein particle clearance (GO:0034383)2.95447409
73membrane raft organization (GO:0031579)2.94063516
74regulation of mononuclear cell migration (GO:0071675)2.93938208
75negative regulation of myeloid cell apoptotic process (GO:0033033)2.91505801
76peptide catabolic process (GO:0043171)2.88420007
77type I interferon signaling pathway (GO:0060337)2.87851262
78cellular response to type I interferon (GO:0071357)2.87851262
79regulation of activation of Janus kinase activity (GO:0010533)2.87594642
80positive regulation of cellular amide metabolic process (GO:0034250)2.86050896
81response to type I interferon (GO:0034340)2.85684836
82regulation of vitamin metabolic process (GO:0030656)2.83708660
83response to peptidoglycan (GO:0032494)2.82178878
84macrophage differentiation (GO:0030225)2.80341033
85regulation of mast cell activation involved in immune response (GO:0033006)2.78233533
86eosinophil migration (GO:0072677)2.78128186
87apoptotic cell clearance (GO:0043277)2.77717397
88cellular response to arsenic-containing substance (GO:0071243)2.76546118
89branching involved in labyrinthine layer morphogenesis (GO:0060670)2.75742585
90myeloid dendritic cell activation (GO:0001773)2.75193479
91positive regulation of heat generation (GO:0031652)2.74875950
92negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73634165
93macrophage activation (GO:0042116)2.71372633
94B cell mediated immunity (GO:0019724)2.71137876
95dendritic cell differentiation (GO:0097028)2.71031608
96regulation of leukocyte degranulation (GO:0043300)2.70077747
97regulation of inflammatory response to antigenic stimulus (GO:0002861)2.69502056
98regulation of interleukin-17 production (GO:0032660)2.69176199
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68985666
100hydrogen peroxide biosynthetic process (GO:0050665)2.68317811
101lytic vacuole organization (GO:0080171)2.68276227
102lysosome organization (GO:0007040)2.68276227
103regulation of fever generation (GO:0031620)2.68149063
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.67450533
105regulation of monocyte chemotaxis (GO:0090025)2.67352381
106growth hormone receptor signaling pathway (GO:0060396)2.66313511
107detection of external biotic stimulus (GO:0098581)2.65505822
108cellular response to lipopolysaccharide (GO:0071222)2.63397615
109positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63307369
110myeloid cell activation involved in immune response (GO:0002275)2.63130113
111detection of other organism (GO:0098543)2.62837326
112cell adhesion mediated by integrin (GO:0033627)2.62764477
113fat-soluble vitamin biosynthetic process (GO:0042362)2.62087930
114folic acid transport (GO:0015884)2.61333670
115positive regulation of interleukin-6 production (GO:0032755)2.59265405
116long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.59145856
117negative regulation of lipid storage (GO:0010888)2.58528145
118leukocyte migration involved in inflammatory response (GO:0002523)2.58317634
119regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.57921049
120cellular response to interferon-alpha (GO:0035457)2.57383384
121regulation of T cell migration (GO:2000404)2.56625912
122response to muramyl dipeptide (GO:0032495)2.56382328
123eosinophil chemotaxis (GO:0048245)2.56211221
124leukocyte mediated cytotoxicity (GO:0001909)2.55781732
125regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55262099
126sphingosine metabolic process (GO:0006670)2.54212555
127ensheathment of neurons (GO:0007272)2.53461432
128axon ensheathment (GO:0008366)2.53461432
129positive regulation of macrophage cytokine production (GO:0060907)2.52248209
130positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.51200797
131glycosylceramide metabolic process (GO:0006677)2.50255984
132membrane protein ectodomain proteolysis (GO:0006509)2.47977532
133myeloid cell homeostasis (GO:0002262)2.47954234
134positive regulation of interleukin-12 production (GO:0032735)2.47880447
135myelination (GO:0042552)2.46795853
136microglial cell activation (GO:0001774)2.46740895
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46524435
138membrane protein proteolysis (GO:0033619)2.45975797
139positive regulation of leukocyte degranulation (GO:0043302)2.45336600
140regulation of lymphocyte migration (GO:2000401)2.44629717
141positive regulation of natural killer cell differentiation (GO:0032825)2.44335954
142protein localization to endosome (GO:0036010)2.44249570
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.43508481
144monocyte chemotaxis (GO:0002548)2.43422345
145positive regulation of type 2 immune response (GO:0002830)2.42856298
146regulation of T-helper 1 cell differentiation (GO:0045625)2.42635701
147cellular response to thyroid hormone stimulus (GO:0097067)2.42495453
148regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.41231216
149positive regulation of T cell migration (GO:2000406)2.40648574
150positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40490712
151lung lobe morphogenesis (GO:0060463)2.40265407
152macrophage chemotaxis (GO:0048246)2.40135337
153cholesterol biosynthetic process (GO:0006695)2.38728672
154cortical actin cytoskeleton organization (GO:0030866)2.38263609
155myeloid dendritic cell differentiation (GO:0043011)2.38235644
156natural killer cell mediated cytotoxicity (GO:0042267)2.37432004
157natural killer cell mediated immunity (GO:0002228)2.37432004
158negative regulation of interleukin-17 production (GO:0032700)2.36895881
159positive regulation of interferon-beta production (GO:0032728)2.36075683
160pinocytosis (GO:0006907)2.33858859
161NIK/NF-kappaB signaling (GO:0038061)2.31741592
162myelin maintenance (GO:0043217)2.30612531
163positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.30603060
164positive regulation of lymphocyte migration (GO:2000403)2.30554654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.74009292
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.30982976
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.98583949
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68871095
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.59713559
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21194160
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18096449
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04088791
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.93676546
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.93196003
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.83361384
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82993296
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.58451140
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41987709
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39542093
16* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.38869498
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34813665
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27339909
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21920651
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19217136
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13516912
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89441666
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82052502
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81195143
25GATA1_22025678_ChIP-Seq_K562_Human1.79759644
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79691044
27* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68324365
28VDR_24763502_ChIP-Seq_THP-1_Human1.67891384
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66607149
30SPI1_23547873_ChIP-Seq_NB4_Human1.64473401
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62821077
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62195436
33SOX2_20726797_ChIP-Seq_SW620_Human1.61095674
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60784304
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59164707
36VDR_24787735_ChIP-Seq_THP-1_Human1.58057966
37CLOCK_20551151_ChIP-Seq_293T_Human1.57118472
38* GATA2_21666600_ChIP-Seq_HMVEC_Human1.51928767
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49008130
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48941024
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48416908
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47211706
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46144395
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45379636
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45170009
46* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44657163
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.44506452
48SPI1_23127762_ChIP-Seq_K562_Human1.44101736
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38868162
50MYB_26560356_Chip-Seq_TH2_Human1.38176295
51LXR_22292898_ChIP-Seq_THP-1_Human1.37846434
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37165461
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.34910646
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.33777950
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32951673
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30781218
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29915077
58MAF_26560356_Chip-Seq_TH1_Human1.28366600
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27251220
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26303909
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.25695042
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24034014
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24034014
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23289312
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23172077
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22966187
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22649287
68RUNX_20019798_ChIP-Seq_JUKART_Human1.22303472
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22052617
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21579729
71PU_27001747_Chip-Seq_BMDM_Mouse1.20768655
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19386262
73VDR_21846776_ChIP-Seq_THP-1_Human1.18790080
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18142220
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17726128
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17368791
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16588454
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.16537209
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16383569
80CJUN_26792858_Chip-Seq_BT549_Human1.15812040
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14994739
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14207835
83GATA3_27048872_Chip-Seq_THYMUS_Human1.13623208
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13303844
85TFEB_21752829_ChIP-Seq_HELA_Human1.13184810
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12889599
87* STAT1_20625510_ChIP-Seq_HELA_Human1.12879901
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12635220
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.12610725
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11921953
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10581991
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08634278
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07187199
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06037295
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05228195
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05228195
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04147591
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04131124
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00355664
100* GATA3_26560356_Chip-Seq_TH2_Human1.00083766
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00073177
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99078735
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.98549738
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98163958
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98098018
106WT1_19549856_ChIP-ChIP_CCG9911_Human0.98048733
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97786238
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96427826
109GATA4_25053715_ChIP-Seq_YYC3_Human0.96201659
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94991578
111GATA1_19941826_ChIP-Seq_K562_Human0.94740382
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94726292
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93093755
114MYB_26560356_Chip-Seq_TH1_Human0.93043723
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87853957
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87836787
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87681817
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87008568
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85443235
120RACK7_27058665_Chip-Seq_MCF-7_Human0.85275714
121EGR1_19032775_ChIP-ChIP_M12_Human0.83900452
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82906978
123* BCL6_27268052_Chip-Seq_Bcells_Human0.82511099
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.81804209
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81501109
126* BCOR_27268052_Chip-Seq_Bcells_Human0.81438257
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81262232
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79668141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.48949409
2MP0004782_abnormal_surfactant_physiolog3.47888516
3* MP0005058_abnormal_lysosome_morphology3.32737030
4MP0001835_abnormal_antigen_presentation3.32310362
5MP0006082_CNS_inflammation3.11898242
6MP0002139_abnormal_hepatobiliary_system2.99910842
7MP0001958_emphysema2.99362821
8MP0003724_increased_susceptibility_to2.75222198
9MP0002148_abnormal_hypersensitivity_rea2.74490752
10MP0003806_abnormal_nucleotide_metabolis2.68969875
11MP0003436_decreased_susceptibility_to2.63682783
12MP0009785_altered_susceptibility_to2.52633833
13MP0002419_abnormal_innate_immunity2.37052986
14MP0000920_abnormal_myelination2.35505584
15MP0005000_abnormal_immune_tolerance2.29223394
16MP0005025_abnormal_response_to2.24843050
17MP0003191_abnormal_cellular_cholesterol2.24273980
18MP0003303_peritoneal_inflammation2.22459361
19* MP0005387_immune_system_phenotype2.18042488
20* MP0001790_abnormal_immune_system2.18042488
21MP0009840_abnormal_foam_cell2.17696027
22MP0003690_abnormal_glial_cell2.04176915
23MP0002138_abnormal_hepatobiliary_system1.94575531
24MP0001533_abnormal_skeleton_physiology1.92573287
25* MP0000685_abnormal_immune_system1.89569292
26MP0002452_abnormal_antigen_presenting1.85149021
27MP0003950_abnormal_plasma_membrane1.84118541
28MP0002295_abnormal_pulmonary_circulatio1.79999361
29MP0005671_abnormal_response_to1.78670405
30MP0002723_abnormal_immune_serum1.77160295
31MP0003448_altered_tumor_morphology1.76449324
32MP0005310_abnormal_salivary_gland1.67686232
33MP0003172_abnormal_lysosome_physiology1.66145911
34MP0002405_respiratory_system_inflammati1.62002969
35MP0000604_amyloidosis1.58402711
36MP0000343_altered_response_to1.57244505
37* MP0001819_abnormal_immune_cell1.54853165
38MP0004510_myositis1.53159651
39* MP0002420_abnormal_adaptive_immunity1.52017347
40MP0001800_abnormal_humoral_immune1.51967912
41MP0004185_abnormal_adipocyte_glucose1.49130352
42MP0001851_eye_inflammation1.48711116
43MP0004947_skin_inflammation1.48641000
44MP0001348_abnormal_lacrimal_gland1.47115952
45MP0005275_abnormal_skin_tensile1.37918195
46MP0002998_abnormal_bone_remodeling1.37193593
47MP0002254_reproductive_system_inflammat1.35091653
48MP0005164_abnormal_response_to1.34881746
49MP0009278_abnormal_bone_marrow1.34786572
50MP0001545_abnormal_hematopoietic_system1.32476030
51MP0005397_hematopoietic_system_phenotyp1.32476030
52MP0005165_increased_susceptibility_to1.31792803
53MP0001845_abnormal_inflammatory_respons1.27285166
54MP0005464_abnormal_platelet_physiology1.26760008
55MP0005388_respiratory_system_phenotype1.25613509
56MP0002133_abnormal_respiratory_system1.25613509
57MP0003566_abnormal_cell_adhesion1.23058672
58MP0003453_abnormal_keratinocyte_physiol1.22600963
59MP0002933_joint_inflammation1.21702550
60MP0002277_abnormal_respiratory_mucosa1.21371251
61MP0005083_abnormal_biliary_tract1.20807444
62MP0003075_altered_response_to1.19993282
63MP0008004_abnormal_stomach_pH1.19713190
64MP0005365_abnormal_bile_salt1.18688241
65MP0004272_abnormal_basement_membrane1.17858017
66MP0009333_abnormal_splenocyte_physiolog1.17493473
67MP0008469_abnormal_protein_level1.17296882
68MP0002090_abnormal_vision1.17041860
69MP0000383_abnormal_hair_follicle1.15744346
70MP0003300_gastrointestinal_ulcer1.15676976
71MP0003186_abnormal_redox_activity1.14995345
72MP0008260_abnormal_autophagy1.12567313
73MP0005257_abnormal_intraocular_pressure1.10896014
74MP0001346_abnormal_lacrimal_gland1.10623137
75MP0003091_abnormal_cell_migration1.09807374
76MP0010678_abnormal_skin_adnexa1.08536487
77MP0010155_abnormal_intestine_physiology1.07900552
78MP0004019_abnormal_vitamin_homeostasis1.07848243
79MP0000858_altered_metastatic_potential1.07482606
80* MP0000716_abnormal_immune_system1.07364309
81MP0002837_dystrophic_cardiac_calcinosis1.06098545
82MP0005451_abnormal_body_composition1.05899302
83MP0003828_pulmonary_edema1.05193441
84MP0001542_abnormal_bone_strength1.04157555
85MP0003634_abnormal_glial_cell1.01471958
86MP0005390_skeleton_phenotype0.99874693
87MP0009764_decreased_sensitivity_to0.98957989
88MP0005023_abnormal_wound_healing0.98925430
89MP0005408_hypopigmentation0.98313450
90MP0002166_altered_tumor_susceptibility0.97742322
91MP0003195_calcinosis0.93952796
92MP0000465_gastrointestinal_hemorrhage0.93932398
93MP0000249_abnormal_blood_vessel0.93662494
94MP0002877_abnormal_melanocyte_morpholog0.93350068
95MP0001853_heart_inflammation0.91249149
96MP0003279_aneurysm0.86583521
97MP0003329_amyloid_beta_deposits0.84284401
98MP0006054_spinal_hemorrhage0.84119356
99MP0002006_tumorigenesis0.83774344
100MP0009763_increased_sensitivity_to0.83247938
101MP0003656_abnormal_erythrocyte_physiolo0.81257391
102* MP0002429_abnormal_blood_cell0.79499373
103MP0001881_abnormal_mammary_gland0.78811337
104MP0005166_decreased_susceptibility_to0.75352957
105MP0005595_abnormal_vascular_smooth0.73965057
106MP0000733_abnormal_muscle_development0.73029673
107MP0000767_abnormal_smooth_muscle0.72693897
108MP0002398_abnormal_bone_marrow0.72390355
109MP0001243_abnormal_dermal_layer0.72381322
110MP0001663_abnormal_digestive_system0.72336200
111MP0001879_abnormal_lymphatic_vessel0.71856413
112MP0000627_abnormal_mammary_gland0.71580834
113MP0005319_abnormal_enzyme/_coenzyme0.71210588
114MP0005167_abnormal_blood-brain_barrier0.71084159
115MP0001175_abnormal_lung_morphology0.70772312
116MP0003795_abnormal_bone_structure0.70764131
117MP0004883_abnormal_blood_vessel0.69518050
118MP0005647_abnormal_sex_gland0.69028771
119MP0010386_abnormal_urinary_bladder0.67856753
120MP0001849_ear_inflammation0.67474931
121MP0003183_abnormal_peptide_metabolism0.67126455
122MP0005584_abnormal_enzyme/coenzyme_acti0.64822830
123MP0000689_abnormal_spleen_morphology0.64651746
124MP0002332_abnormal_exercise_endurance0.63144779
125MP0000371_diluted_coat_color0.62455587
126MP0009765_abnormal_xenobiotic_induced0.55625895
127MP0000490_abnormal_crypts_of0.55109487

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)6.59413714
2Vacuolated lymphocytes (HP:0001922)5.13310915
3Recurrent abscess formation (HP:0002722)5.04452572
4Eczematoid dermatitis (HP:0000976)4.84996274
5Increased cerebral lipofuscin (HP:0011813)4.73371215
6Recurrent bacterial skin infections (HP:0005406)4.63354322
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.42168684
8Mutism (HP:0002300)4.08501508
9Nuclear cataract (HP:0100018)4.01514165
10* Abnormality of macrophages (HP:0004311)3.93044938
11Dysostosis multiplex (HP:0000943)3.86884834
12Abnormality of liposaccharide metabolism (HP:0010968)3.75360000
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.75360000
14Abnormality of glycolipid metabolism (HP:0010969)3.75360000
15* Loss of speech (HP:0002371)3.75200315
16Chronic otitis media (HP:0000389)3.72880740
17Axonal loss (HP:0003447)3.63388279
18Recurrent gram-negative bacterial infections (HP:0005420)3.61043570
19Hepatosplenomegaly (HP:0001433)3.60427167
20Osteolytic defects of the hand bones (HP:0009699)3.57865122
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.57865122
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.56735511
23Elevated erythrocyte sedimentation rate (HP:0003565)3.35248785
24Complement deficiency (HP:0004431)3.29698643
25Parakeratosis (HP:0001036)3.28161529
26Systemic lupus erythematosus (HP:0002725)3.24178225
27Recurrent skin infections (HP:0001581)3.21020530
28Premature rupture of membranes (HP:0001788)3.01755287
29Agnosia (HP:0010524)2.91246943
30Autoimmune thrombocytopenia (HP:0001973)2.89244370
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80905978
32Apathy (HP:0000741)2.80724418
33Diminished motivation (HP:0000745)2.79154052
34Abnormality of complement system (HP:0005339)2.75869448
35Upper motor neuron abnormality (HP:0002127)2.70799989
36Mucopolysacchariduria (HP:0008155)2.67320251
37Urinary glycosaminoglycan excretion (HP:0003541)2.67320251
38Thick nail (HP:0001805)2.62304094
39Inappropriate behavior (HP:0000719)2.59685427
40Hematochezia (HP:0002573)2.55217066
41Spontaneous hematomas (HP:0007420)2.50608740
42Peritonitis (HP:0002586)2.50425728
43Retinal atrophy (HP:0001105)2.48966262
44Vertebral compression fractures (HP:0002953)2.48385780
45Metaphyseal irregularity (HP:0003025)2.48275394
46Pustule (HP:0200039)2.47968803
47Neuronal loss in central nervous system (HP:0002529)2.47724041
48Increased serum ferritin (HP:0003281)2.46726281
49Stomatitis (HP:0010280)2.44194388
50Obstructive lung disease (HP:0006536)2.43967155
51Chronic obstructive pulmonary disease (HP:0006510)2.43967155
52Disinhibition (HP:0000734)2.43381064
53Petechiae (HP:0000967)2.41635967
54Recurrent fungal infections (HP:0002841)2.41216930
55Tubulointerstitial fibrosis (HP:0005576)2.38520997
56Ulnar bowing (HP:0003031)2.38159701
57Abnormality of polysaccharide metabolism (HP:0011012)2.35398199
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35398199
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35398199
60Abnormality of the nasal mucosa (HP:0000433)2.34025202
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33319736
62Beaking of vertebral bodies (HP:0004568)2.33082906
63Respiratory distress (HP:0002098)2.32553941
64Myositis (HP:0100614)2.31030077
65Gingivitis (HP:0000230)2.29251227
66Segmental peripheral demyelination/remyelination (HP:0003481)2.29160858
67Congenital ichthyosiform erythroderma (HP:0007431)2.24834945
68Orchitis (HP:0100796)2.23972078
69Basal ganglia calcification (HP:0002135)2.23450680
70Hypergammaglobulinemia (HP:0010702)2.22169247
71Stridor (HP:0010307)2.21050687
72Purpura (HP:0000979)2.20910440
73Premature skin wrinkling (HP:0100678)2.19310053
74Personality changes (HP:0000751)2.17685759
75Cardiomegaly (HP:0001640)2.17366490
76Nausea (HP:0002018)2.17038093
77Malnutrition (HP:0004395)2.15121610
78Mediastinal lymphadenopathy (HP:0100721)2.14404731
79Increased CSF protein (HP:0002922)2.13090826
80Nephritis (HP:0000123)2.13082847
81Asymmetric septal hypertrophy (HP:0001670)2.13057195
82Tetraparesis (HP:0002273)2.11892295
83* Dementia (HP:0000726)2.11611681
84Vasculitis (HP:0002633)2.11007651
85Conjunctival telangiectasia (HP:0000524)2.09948892
86Cellulitis (HP:0100658)2.08269903
87Osteomyelitis (HP:0002754)2.06762127
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05828574
89Recurrent viral infections (HP:0004429)2.01633563
90Nasal polyposis (HP:0100582)2.01397032
91Increased IgM level (HP:0003496)2.01145428
92Poor head control (HP:0002421)1.99710901
93Progressive neurologic deterioration (HP:0002344)1.99613376
94Cerebral hemorrhage (HP:0001342)1.97075662
95Abnormality of iron homeostasis (HP:0011031)1.96851984
96Leukocytosis (HP:0001974)1.96365668
97Glomerulonephritis (HP:0000099)1.94612574
98J-shaped sella turcica (HP:0002680)1.94230761
99Polyneuropathy (HP:0001271)1.94126475
100Pulmonary infiltrates (HP:0002113)1.94030040
101Abnormality of the lumbar spine (HP:0100712)1.92980497
102Global brain atrophy (HP:0002283)1.90973941
103Abnormality of the basal ganglia (HP:0002134)1.90941127
104Xanthomatosis (HP:0000991)1.89030583
105Recurrent pneumonia (HP:0006532)1.88728239
106* Neurofibrillary tangles (HP:0002185)1.88222446
107Peripheral demyelination (HP:0011096)1.88183817
108Amyloidosis (HP:0011034)1.86754343
109Bone cyst (HP:0012062)1.86402305
110Abnormal hemoglobin (HP:0011902)1.85707248
111Spondylolisthesis (HP:0003302)1.85465874
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84664881
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.84664881
114Renal salt wasting (HP:0000127)1.82068970
115Mucosal telangiectasiae (HP:0100579)1.81342653
116Pathologic fracture (HP:0002756)1.80900593
117Myocardial infarction (HP:0001658)1.80632281
118Retrobulbar optic neuritis (HP:0100654)1.79585038
119Optic neuritis (HP:0100653)1.79585038
120Bone pain (HP:0002653)1.79443737
121Joint stiffness (HP:0001387)1.78727697
122Sensory axonal neuropathy (HP:0003390)1.78702672
123Restrictive lung disease (HP:0002091)1.77744491
124Urticaria (HP:0001025)1.77354366
125Vascular tortuosity (HP:0004948)1.76285775
126Emphysema (HP:0002097)1.76226395
127Chronic mucocutaneous candidiasis (HP:0002728)1.76165517
128Recurrent cutaneous fungal infections (HP:0011370)1.76165517
129Progressive visual loss (HP:0000529)1.74975610
130Abnormal umbilical cord blood vessels (HP:0011403)1.74841063
131Single umbilical artery (HP:0001195)1.74841063
132Abnormality of the fetal cardiovascular system (HP:0010948)1.74841063
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73277946
134Eosinophilia (HP:0001880)1.73053877
135Arterial tortuosity (HP:0005116)1.73015969
136Thoracic kyphosis (HP:0002942)1.71721274
137Zonular cataract (HP:0010920)1.68282781
138Protuberant abdomen (HP:0001538)1.67707878
139Memory impairment (HP:0002354)1.60821197
140Premature loss of primary teeth (HP:0006323)1.56594757
141Multiple enchondromatosis (HP:0005701)1.54854513
142Hemoptysis (HP:0002105)1.53244144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.11129458
2PBK3.35404336
3STK393.17724195
4GRK73.11390597
5BLK2.72035105
6MST42.54247449
7TBK12.48580484
8TYK22.42282876
9MAP3K142.36085538
10TAOK22.33971117
11ACVR1B2.30535137
12IRAK42.09937850
13MET2.04104420
14MAP3K112.01591547
15PIM21.97188614
16LRRK21.95632569
17IKBKE1.87116324
18IKBKB1.83846836
19ERN11.77884911
20IRAK31.74277314
21ZAP701.66647701
22KIT1.62641958
23TAOK11.61376663
24STK101.57579979
25JAK31.56220857
26BCR1.52580925
27TGFBR21.51521278
28MAP2K31.49367438
29CSK1.41825843
30JAK11.41072370
31RIPK11.38988008
32LIMK11.38833914
33TESK21.38362004
34FGFR21.38213923
35MAP4K11.36518863
36PDK21.36274925
37OXSR11.35845773
38TRIB31.27598549
39FGFR41.25203908
40WNK41.24765365
41NME21.24127153
42EPHA31.22649030
43ADRBK21.20322213
44CDC42BPA1.16443050
45TAOK31.15400113
46BMX1.14880417
47MAP3K121.14025536
48PKN11.09658028
49FGR1.08111661
50ARAF1.07786613
51NEK91.07229291
52TESK11.05760025
53TGFBR11.04825186
54CAMKK21.03907670
55CSF1R1.03877942
56MAPKAPK51.00004677
57CLK10.96938244
58PAK40.94167892
59CHUK0.94165932
60STK160.93668263
61PDGFRB0.93438586
62MST1R0.92871525
63MAP3K130.92771272
64IRAK10.92317123
65ABL20.90853518
66MAP3K10.89651001
67TRPM70.86561188
68LCK0.85582329
69NTRK10.84406788
70MAP2K60.83841499
71RIPK40.83393555
72EPHA20.83355056
73ITK0.82596602
74STK40.82352637
75WNK10.81962497
76RPS6KA40.81880838
77BMPR20.80430404
78PRPF4B0.79718070
79PRKCQ0.79012536
80MARK30.78226861
81ILK0.76757176
82DDR20.76203527
83RPS6KA50.76107544
84MAP3K50.73376209
85HCK0.70857971
86MOS0.70812054
87CAMK1D0.70650954
88ABL10.67655851
89EPHB20.67614274
90STK240.66345320
91ROCK20.64835948
92GSK3A0.63051087
93CDK60.62931798
94MYLK0.61500214
95EGFR0.60191885
96JAK20.60175712
97STK30.60089483
98MAP2K20.59664022
99PIK3CG0.59495766
100CSNK1A1L0.58214132
101LYN0.57782411
102PTK60.57644188
103PRKD10.57575452
104IRAK20.57380985
105BTK0.56493774
106TEC0.54836370
107MAPKAPK20.54638728
108MAPK150.54109751
109PIM10.53753867
110FGFR30.53562186
111CSNK1G30.53333709
112PRKCD0.52813271
113MAP3K30.52640435
114SYK0.52276342
115BMPR1B0.51356341
116PRKG20.50435762
117TXK0.49601762
118TTN0.47502612
119NLK0.47014881
120DAPK30.46978614
121DAPK20.46101634
122ERBB40.45624889
123PDGFRA0.44942582
124PAK10.44526582
125FES0.44525821
126SIK30.43388661
127MATK0.42415334
128DYRK1B0.42176617
129BCKDK0.40004060
130PDPK10.39316699
131LATS20.32065793
132BRAF0.30734623
133INSR0.28177423
134RPS6KL10.25965737
135RPS6KC10.25965737
136FER0.25063575
137DYRK30.24331925
138MAP3K80.23876828
139MAPK70.23122612
140DAPK10.21129399

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysosome_Homo sapiens_hsa041423.09204651
2Steroid biosynthesis_Homo sapiens_hsa001002.82840664
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.68374187
4Malaria_Homo sapiens_hsa051442.34228700
5Leishmaniasis_Homo sapiens_hsa051402.23076308
6Rheumatoid arthritis_Homo sapiens_hsa053232.22447661
7Other glycan degradation_Homo sapiens_hsa005112.20002494
8Staphylococcus aureus infection_Homo sapiens_hsa051502.08689538
9Pertussis_Homo sapiens_hsa051332.04918567
10Phagosome_Homo sapiens_hsa041452.04023672
11Graft-versus-host disease_Homo sapiens_hsa053321.91210295
12Allograft rejection_Homo sapiens_hsa053301.89431593
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86990482
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.86521485
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83686831
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.80667120
17Fatty acid elongation_Homo sapiens_hsa000621.71498157
18Osteoclast differentiation_Homo sapiens_hsa043801.66619648
19Sphingolipid metabolism_Homo sapiens_hsa006001.66007817
20Ether lipid metabolism_Homo sapiens_hsa005651.65196554
21Autoimmune thyroid disease_Homo sapiens_hsa053201.57186045
22Tuberculosis_Homo sapiens_hsa051521.55360437
23Antigen processing and presentation_Homo sapiens_hsa046121.50771304
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50302551
25Measles_Homo sapiens_hsa051621.50171483
26Complement and coagulation cascades_Homo sapiens_hsa046101.48373364
27Legionellosis_Homo sapiens_hsa051341.47154755
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.46210513
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46036666
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42475801
31Protein export_Homo sapiens_hsa030601.41061339
32Toxoplasmosis_Homo sapiens_hsa051451.40637106
33Salmonella infection_Homo sapiens_hsa051321.33674423
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.31731891
35Shigellosis_Homo sapiens_hsa051311.29654367
36Sulfur metabolism_Homo sapiens_hsa009201.29030362
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26476126
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26373810
39Asthma_Homo sapiens_hsa053101.25893167
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25070616
41Apoptosis_Homo sapiens_hsa042101.24179490
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21423728
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15663174
44Oxidative phosphorylation_Homo sapiens_hsa001901.15469668
45TNF signaling pathway_Homo sapiens_hsa046681.13639470
46Chemokine signaling pathway_Homo sapiens_hsa040621.10953844
47Mineral absorption_Homo sapiens_hsa049781.09077711
48ECM-receptor interaction_Homo sapiens_hsa045121.07111155
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06493662
50B cell receptor signaling pathway_Homo sapiens_hsa046621.02956223
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.02891449
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02196359
53Hematopoietic cell lineage_Homo sapiens_hsa046401.01941485
54Galactose metabolism_Homo sapiens_hsa000521.01203670
55Influenza A_Homo sapiens_hsa051641.00959589
56Hepatitis C_Homo sapiens_hsa051600.99727072
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95759960
58Amoebiasis_Homo sapiens_hsa051460.94541140
59Viral myocarditis_Homo sapiens_hsa054160.92783420
60Proteasome_Homo sapiens_hsa030500.92765116
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92058118
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91436965
63Renal cell carcinoma_Homo sapiens_hsa052110.89613363
64Endocytosis_Homo sapiens_hsa041440.88077275
65Vibrio cholerae infection_Homo sapiens_hsa051100.86262738
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.83040052
67Primary immunodeficiency_Homo sapiens_hsa053400.80396357
68Herpes simplex infection_Homo sapiens_hsa051680.79898520
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.79777388
70Histidine metabolism_Homo sapiens_hsa003400.79698792
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79318572
72Arachidonic acid metabolism_Homo sapiens_hsa005900.77112177
73Collecting duct acid secretion_Homo sapiens_hsa049660.76252205
74Bladder cancer_Homo sapiens_hsa052190.72985724
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71700183
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71113497
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67642486
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65547201
79Small cell lung cancer_Homo sapiens_hsa052220.64615966
80Prion diseases_Homo sapiens_hsa050200.64533447
81Caffeine metabolism_Homo sapiens_hsa002320.64525322
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63552390
83Focal adhesion_Homo sapiens_hsa045100.62269825
84Glutathione metabolism_Homo sapiens_hsa004800.62150994
85Pancreatic cancer_Homo sapiens_hsa052120.60876815
86Proteoglycans in cancer_Homo sapiens_hsa052050.60536595
87African trypanosomiasis_Homo sapiens_hsa051430.59860276
88Hepatitis B_Homo sapiens_hsa051610.58998208
89Linoleic acid metabolism_Homo sapiens_hsa005910.58977043
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57908872
91PPAR signaling pathway_Homo sapiens_hsa033200.57602971
92T cell receptor signaling pathway_Homo sapiens_hsa046600.57404408
93Folate biosynthesis_Homo sapiens_hsa007900.55832240
94Renin-angiotensin system_Homo sapiens_hsa046140.55221325
95Chronic myeloid leukemia_Homo sapiens_hsa052200.52210106
96Platelet activation_Homo sapiens_hsa046110.51809850
97Type I diabetes mellitus_Homo sapiens_hsa049400.51269293
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.47528617
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45848034
100Fatty acid biosynthesis_Homo sapiens_hsa000610.44711612
101Acute myeloid leukemia_Homo sapiens_hsa052210.44608674
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44128646
103Tryptophan metabolism_Homo sapiens_hsa003800.43417708
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42583988
105Epstein-Barr virus infection_Homo sapiens_hsa051690.42041791
106Tight junction_Homo sapiens_hsa045300.41018188
107Parkinsons disease_Homo sapiens_hsa050120.40948319
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39882594
109Fructose and mannose metabolism_Homo sapiens_hsa000510.38665003
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38075705
111Viral carcinogenesis_Homo sapiens_hsa052030.37819834
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37013657
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36746218
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33537319
115Alzheimers disease_Homo sapiens_hsa050100.32466315
116Pentose phosphate pathway_Homo sapiens_hsa000300.31024630
117Synaptic vesicle cycle_Homo sapiens_hsa047210.28016267
118Systemic lupus erythematosus_Homo sapiens_hsa053220.17729970
119HIF-1 signaling pathway_Homo sapiens_hsa040660.17424586
120Huntingtons disease_Homo sapiens_hsa050160.15760658
121HTLV-I infection_Homo sapiens_hsa051660.15349809
122Ribosome_Homo sapiens_hsa030100.11354292
123N-Glycan biosynthesis_Homo sapiens_hsa005100.10856183
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.10693798
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07346184

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