NPEPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83337649
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83337649
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.56137766
4negative regulation of cell killing (GO:0031342)4.56137766
5valine metabolic process (GO:0006573)4.32206677
6antigen processing and presentation of endogenous antigen (GO:0019883)4.25578050
7L-phenylalanine metabolic process (GO:0006558)4.09612448
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.09612448
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04100121
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.04100121
11modulation by symbiont of host immune response (GO:0052553)4.04100121
12positive regulation by symbiont of host defense response (GO:0052509)4.04100121
13modulation by symbiont of host defense response (GO:0052031)4.04100121
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04100121
15mannose metabolic process (GO:0006013)4.01370382
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93199852
17detection of bacterium (GO:0016045)3.88287621
18detection of other organism (GO:0098543)3.87080132
19response to peptidoglycan (GO:0032494)3.85388567
20leukocyte aggregation (GO:0070486)3.81343413
21L-phenylalanine catabolic process (GO:0006559)3.78493739
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78493739
23tricarboxylic acid metabolic process (GO:0072350)3.77386994
24lysine metabolic process (GO:0006553)3.70012234
25lysine catabolic process (GO:0006554)3.70012234
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.66328804
27positive regulation of Cdc42 GTPase activity (GO:0043089)3.63599771
282-oxoglutarate metabolic process (GO:0006103)3.53575682
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47470567
30macrophage activation involved in immune response (GO:0002281)3.41840886
31response to muramyl dipeptide (GO:0032495)3.39385472
32glyoxylate metabolic process (GO:0046487)3.37147495
33ribosomal small subunit assembly (GO:0000028)3.32191524
34neutrophil activation involved in immune response (GO:0002283)3.25810788
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.18920518
36regulation of gamma-delta T cell differentiation (GO:0045586)3.16136963
37aromatic amino acid family catabolic process (GO:0009074)3.15071485
38fatty acid beta-oxidation (GO:0006635)3.14864453
39alpha-linolenic acid metabolic process (GO:0036109)3.13874969
40detection of external biotic stimulus (GO:0098581)3.13836256
41protein carboxylation (GO:0018214)3.12077513
42peptidyl-glutamic acid carboxylation (GO:0017187)3.12077513
43oxaloacetate metabolic process (GO:0006107)3.09371011
44germinal center formation (GO:0002467)3.08797333
45regulation of interferon-beta biosynthetic process (GO:0045357)3.08070276
46positive regulation of gamma-delta T cell activation (GO:0046645)3.06148241
47thymic T cell selection (GO:0045061)3.04643366
48cysteine metabolic process (GO:0006534)3.03714004
49kynurenine metabolic process (GO:0070189)3.02354590
50regulation of T-helper 2 cell differentiation (GO:0045628)3.02094074
51sulfur amino acid catabolic process (GO:0000098)3.00105327
52regulation of cholesterol homeostasis (GO:2000188)2.96732726
53amino-acid betaine metabolic process (GO:0006577)2.91876380
54regulation of triglyceride catabolic process (GO:0010896)2.90115651
55COPI coating of Golgi vesicle (GO:0048205)2.89631560
56Golgi transport vesicle coating (GO:0048200)2.89631560
57ethanol oxidation (GO:0006069)2.88624389
58glycine metabolic process (GO:0006544)2.88600195
594-hydroxyproline metabolic process (GO:0019471)2.88549368
60fatty acid oxidation (GO:0019395)2.87955380
61negative regulation of erythrocyte differentiation (GO:0045647)2.84408136
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83992772
63response to laminar fluid shear stress (GO:0034616)2.83352137
64viral transcription (GO:0019083)2.83192282
65lipid oxidation (GO:0034440)2.80686000
66detection of biotic stimulus (GO:0009595)2.79373162
67positive regulation of triglyceride metabolic process (GO:0090208)2.79206526
68regulation of leukocyte degranulation (GO:0043300)2.78425003
69epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77601412
70fatty acid catabolic process (GO:0009062)2.77495526
71regulation of ARF GTPase activity (GO:0032312)2.77137687
72positive regulation of triglyceride biosynthetic process (GO:0010867)2.76235160
73negative regulation of granulocyte differentiation (GO:0030853)2.76215338
74regulation of extracellular matrix disassembly (GO:0010715)2.74425531
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.73911709
76negative regulation of interleukin-12 production (GO:0032695)2.73548081
77regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72556894
78T cell selection (GO:0045058)2.71881272
79regulation of gamma-delta T cell activation (GO:0046643)2.71586182
80carnitine metabolic process (GO:0009437)2.70453077
81antigen processing and presentation via MHC class Ib (GO:0002475)2.70350303
82negative regulation of fibrinolysis (GO:0051918)2.70240499
83positive regulation of histone deacetylation (GO:0031065)2.70045994
84negative regulation of leukocyte mediated immunity (GO:0002704)2.69247019
85indole-containing compound catabolic process (GO:0042436)2.69074814
86indolalkylamine catabolic process (GO:0046218)2.69074814
87tryptophan catabolic process (GO:0006569)2.69074814
88response to host (GO:0075136)2.68565630
89response to host defenses (GO:0052200)2.68565630
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68565630
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68514624
92branched-chain amino acid metabolic process (GO:0009081)2.67393796
93translational termination (GO:0006415)2.66407419
94complement activation, alternative pathway (GO:0006957)2.66005941
95regulation of mast cell degranulation (GO:0043304)2.65807642
96response to host immune response (GO:0052572)2.65682497
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65682497
98modulation by virus of host process (GO:0019054)2.65301199
99NIK/NF-kappaB signaling (GO:0038061)2.65159198
100tryptophan metabolic process (GO:0006568)2.65044760
101modulation by symbiont of host cellular process (GO:0044068)2.63141334
102pentose-phosphate shunt (GO:0006098)2.61876328
103plasma lipoprotein particle clearance (GO:0034381)2.61792599
104detection of molecule of bacterial origin (GO:0032490)2.61762692
105protein targeting to ER (GO:0045047)2.61358260
106regulation of fatty acid beta-oxidation (GO:0031998)2.61148786
107positive regulation of fatty acid beta-oxidation (GO:0032000)2.60424815
108homocysteine metabolic process (GO:0050667)2.59399316
109urea metabolic process (GO:0019627)2.58781285
110urea cycle (GO:0000050)2.58781285
111tolerance induction (GO:0002507)2.58714937
112folic acid-containing compound biosynthetic process (GO:0009396)2.58383923
113serine family amino acid catabolic process (GO:0009071)2.58301835
114drug transmembrane transport (GO:0006855)2.58155816
115maternal placenta development (GO:0001893)2.57771769
116response to type I interferon (GO:0034340)2.57710735
117positive thymic T cell selection (GO:0045059)2.57662057
118negative regulation of cell size (GO:0045792)2.57080840
119cellular extravasation (GO:0045123)2.56544138
120bile acid biosynthetic process (GO:0006699)2.56507354
121cotranslational protein targeting to membrane (GO:0006613)2.56400160
122negative regulation of innate immune response (GO:0045824)2.55188703
123fatty acid transmembrane transport (GO:1902001)2.54613120
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54507339
125short-chain fatty acid metabolic process (GO:0046459)2.53825178
126macrophage activation (GO:0042116)2.53809808
127type I interferon signaling pathway (GO:0060337)2.53793501
128cellular response to type I interferon (GO:0071357)2.53793501
129immunoglobulin mediated immune response (GO:0016064)2.53019738
130monocarboxylic acid catabolic process (GO:0072329)2.51797229
131aspartate family amino acid catabolic process (GO:0009068)2.51641961
132negative regulation of sterol transport (GO:0032372)2.51332946
133negative regulation of cholesterol transport (GO:0032375)2.51332946
134positive regulation of protein deacetylation (GO:0090312)2.51200180
135respiratory burst (GO:0045730)2.50566765
136establishment of protein localization to endoplasmic reticulum (GO:0072599)2.50380568
137triglyceride homeostasis (GO:0070328)2.50310063
138acylglycerol homeostasis (GO:0055090)2.50310063
139serine family amino acid metabolic process (GO:0009069)2.49379254
140low-density lipoprotein particle clearance (GO:0034383)2.47850648
141phospholipid efflux (GO:0033700)2.47808542
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46426896
143regulation of protein activation cascade (GO:2000257)2.45010037
144protein localization to endoplasmic reticulum (GO:0070972)2.44371928
145acetyl-CoA metabolic process (GO:0006084)2.44354623
146translational elongation (GO:0006414)2.44353826
147regulation of fatty acid oxidation (GO:0046320)2.43608375
148negative regulation of cytokine production involved in immune response (GO:0002719)2.43102308
149cellular modified amino acid catabolic process (GO:0042219)2.43050814
150serine family amino acid biosynthetic process (GO:0009070)2.41781643
151neutrophil activation (GO:0042119)2.41339709
152high-density lipoprotein particle remodeling (GO:0034375)2.40930931
153semaphorin-plexin signaling pathway (GO:0071526)2.40910762
154barbed-end actin filament capping (GO:0051016)2.40718565
155regulation of cholesterol storage (GO:0010885)2.40485340
156negative regulation of type 2 immune response (GO:0002829)2.39957223
157positive regulation of cellular amide metabolic process (GO:0034250)2.39617816
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39291480
159regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39250844
160regulation of regulated secretory pathway (GO:1903305)2.39189753
161negative regulation of interleukin-6 production (GO:0032715)2.39081918
162nitrogen cycle metabolic process (GO:0071941)2.38497717
163regulation of cholesterol metabolic process (GO:0090181)2.37004280
164regulation of triglyceride metabolic process (GO:0090207)2.36969327
165carnitine shuttle (GO:0006853)2.36900622
166cellular response to virus (GO:0098586)2.36185457
167apoptotic process involved in morphogenesis (GO:0060561)2.35892674
168pteridine-containing compound biosynthetic process (GO:0042559)2.35828826
169signal complex assembly (GO:0007172)2.35464740
170peptidyl-tyrosine autophosphorylation (GO:0038083)2.35171583
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34545398
172regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.34265686
173alpha-amino acid catabolic process (GO:1901606)2.34105779
174regulation of fibrinolysis (GO:0051917)2.33779001
175purine nucleotide salvage (GO:0032261)2.33646915
176regulation of complement activation (GO:0030449)2.33023209
177focal adhesion assembly (GO:0048041)2.32696994
178cell-substrate adherens junction assembly (GO:0007045)2.32696994
179intracellular estrogen receptor signaling pathway (GO:0030520)2.32349808
180actin filament polymerization (GO:0030041)2.32099787
181regulation of ARF protein signal transduction (GO:0032012)2.31997526
182negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31549937
183stress fiber assembly (GO:0043149)2.31185353
184leukocyte migration involved in inflammatory response (GO:0002523)2.29723483
185regulation of lipid kinase activity (GO:0043550)2.29564763
186granulocyte activation (GO:0036230)2.29283364
1873-UTR-mediated mRNA stabilization (GO:0070935)2.29036932
188positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.27598913
189regulation of mast cell activation involved in immune response (GO:0033006)2.26976942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.88911324
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88824443
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.46619371
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.31855579
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.73337546
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.57732820
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47951395
8MYC_22102868_ChIP-Seq_BL_Human2.42545510
9VDR_21846776_ChIP-Seq_THP-1_Human2.30059516
10E2F7_22180533_ChIP-Seq_HELA_Human2.25693171
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.22318687
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19713738
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14130844
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03435144
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00513897
16SCL_19346495_ChIP-Seq_HPC-7_Human1.98471860
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88034511
18GATA1_22025678_ChIP-Seq_K562_Human1.86385447
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85945647
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84713827
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81159502
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80017818
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79880709
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78750044
25KDM2B_26808549_Chip-Seq_K562_Human1.78707230
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76896734
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74666842
28P68_20966046_ChIP-Seq_HELA_Human1.74227230
29MAF_26560356_Chip-Seq_TH1_Human1.70000383
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66439089
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65746016
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64010021
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63052366
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60886972
35CLOCK_20551151_ChIP-Seq_293T_Human1.60423993
36TCF7_22412390_ChIP-Seq_EML_Mouse1.59965920
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.59285478
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.58354560
39SMC4_20622854_ChIP-Seq_HELA_Human1.57935410
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.57634208
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57604537
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56515948
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.55996615
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55968333
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55826860
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55491816
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.55038375
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54993896
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.54322182
50VDR_24763502_ChIP-Seq_THP-1_Human1.52785281
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52101307
52UTX_26944678_Chip-Seq_JUKART_Human1.50535749
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.49882338
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.48529534
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46462294
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45359758
57* LXR_22292898_ChIP-Seq_THP-1_Human1.44982175
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.43984655
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.43414446
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42951766
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41325057
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39474672
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39050062
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39041508
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38437577
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38239703
67BCOR_27268052_Chip-Seq_Bcells_Human1.36602471
68CREB1_26743006_Chip-Seq_LNCaP_Human1.35255381
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33438751
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32937709
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32686253
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32530891
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31621543
74* MYC_18555785_ChIP-Seq_MESCs_Mouse1.28532166
75MYB_26560356_Chip-Seq_TH1_Human1.28176967
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27366792
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27087722
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.26800655
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26760972
80MYB_26560356_Chip-Seq_TH2_Human1.26514146
81SPI1_23547873_ChIP-Seq_NB4_Human1.24727144
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.24575850
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23912412
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23756253
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21666833
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21608184
87KDM2B_26808549_Chip-Seq_DND41_Human1.21367050
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20313588
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20289535
90MAF_26560356_Chip-Seq_TH2_Human1.19764832
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19726342
92ZNF263_19887448_ChIP-Seq_K562_Human1.19295095
93* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18542711
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18456374
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18432472
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18326649
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17868006
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17831745
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16665006
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16529821
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16273986
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15566994
103CTCF_27219007_Chip-Seq_Bcells_Human1.15330371
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.14887667
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14257315
106RACK7_27058665_Chip-Seq_MCF-7_Human1.13583270
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13431565
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.13355956
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12602542
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11236589
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10758164
112CIITA_25753668_ChIP-Seq_RAJI_Human1.10283838
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10117110
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.09944194
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09297369
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08118222
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06566015
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06451179
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06412471
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06276350
121DROSHA_22980978_ChIP-Seq_HELA_Human1.04833812
122NCOR1_26117541_ChIP-Seq_K562_Human1.03741836
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03218161
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02804083
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02789443
126TP63_22573176_ChIP-Seq_HFKS_Human1.02675691
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02086976
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01347475
129SA1_27219007_Chip-Seq_Bcells_Human1.00940074
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00869965
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98739943
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.98388071
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97696183
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96308467
135CTCF_21964334_Chip-Seq_Bcells_Human0.95935127
136ATF3_27146783_Chip-Seq_COLON_Human0.95557524
137SPI1_23127762_ChIP-Seq_K562_Human0.95440416
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94289974
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93298714
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.91563982
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90395119
142XRN2_22483619_ChIP-Seq_HELA_Human0.88878505
143* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88110886
144BCL6_27268052_Chip-Seq_Bcells_Human0.87948776
145CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87362782
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86700452
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86623369
148SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86398422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.71189494
2MP0005360_urolithiasis3.33904711
3MP0005365_abnormal_bile_salt2.95067715
4MP0003172_abnormal_lysosome_physiology2.80660022
5MP0008260_abnormal_autophagy2.79263571
6MP0005085_abnormal_gallbladder_physiolo2.63398883
7MP0005451_abnormal_body_composition2.57823773
8MP0009840_abnormal_foam_cell2.46866378
9MP0003806_abnormal_nucleotide_metabolis2.13795815
10MP0003252_abnormal_bile_duct2.09161130
11MP0003300_gastrointestinal_ulcer2.05918998
12MP0004510_myositis2.05029732
13MP0003191_abnormal_cellular_cholesterol2.00643931
14MP0004381_abnormal_hair_follicle1.98389363
15MP0008875_abnormal_xenobiotic_pharmacok1.85259627
16MP0005076_abnormal_cell_differentiation1.83129143
17MP0005083_abnormal_biliary_tract1.82807606
18MP0000685_abnormal_immune_system1.82627904
19MP0010329_abnormal_lipoprotein_level1.79161858
20MP0001849_ear_inflammation1.77757931
21MP0003705_abnormal_hypodermis_morpholog1.70496523
22MP0003195_calcinosis1.65378024
23MP0002138_abnormal_hepatobiliary_system1.64832991
24MP0001835_abnormal_antigen_presentation1.61593389
25MP0001666_abnormal_nutrient_absorption1.59657961
26MP0000609_abnormal_liver_physiology1.57742869
27MP0002877_abnormal_melanocyte_morpholog1.57445208
28MP0009643_abnormal_urine_homeostasis1.57000850
29MP0006082_CNS_inflammation1.56372244
30MP0003828_pulmonary_edema1.55786489
31MP0003436_decreased_susceptibility_to1.54910660
32MP0004858_abnormal_nervous_system1.53747515
33MP0000751_myopathy1.52673511
34MP0002396_abnormal_hematopoietic_system1.51563148
35MP0005332_abnormal_amino_acid1.45942406
36MP0002998_abnormal_bone_remodeling1.44236080
37MP0002132_abnormal_respiratory_system1.43921884
38MP0000858_altered_metastatic_potential1.41890997
39MP0005670_abnormal_white_adipose1.41854463
40MP0003724_increased_susceptibility_to1.41572995
41MP0005319_abnormal_enzyme/_coenzyme1.38262677
42MP0002837_dystrophic_cardiac_calcinosis1.37161516
43MP0003763_abnormal_thymus_physiology1.35703853
44MP0004130_abnormal_muscle_cell1.33951495
45MP0005666_abnormal_adipose_tissue1.32613593
46MP0002166_altered_tumor_susceptibility1.32479580
47MP0005464_abnormal_platelet_physiology1.31869162
48MP0001790_abnormal_immune_system1.27959412
49MP0005387_immune_system_phenotype1.27959412
50MP0003303_peritoneal_inflammation1.27433182
51MP0003279_aneurysm1.26586846
52MP0010368_abnormal_lymphatic_system1.26443526
53MP0002148_abnormal_hypersensitivity_rea1.25398743
54MP0002118_abnormal_lipid_homeostasis1.25094315
55MP0003183_abnormal_peptide_metabolism1.24513588
56MP0003453_abnormal_keratinocyte_physiol1.24362727
57MP0001958_emphysema1.24147687
58MP0004185_abnormal_adipocyte_glucose1.23662820
59MP0006036_abnormal_mitochondrial_physio1.22031640
60MP0006054_spinal_hemorrhage1.21374511
61MP0003075_altered_response_to1.19328925
62MP0001853_heart_inflammation1.19068315
63MP0005025_abnormal_response_to1.18450978
64MP0001800_abnormal_humoral_immune1.18133107
65MP0005409_darkened_coat_color1.17892052
66MP0005058_abnormal_lysosome_morphology1.17849322
67MP0008469_abnormal_protein_level1.14876211
68MP0002249_abnormal_larynx_morphology1.14455049
69MP0005220_abnormal_exocrine_pancreas1.11232353
70MP0000598_abnormal_liver_morphology1.09823638
71MP0004084_abnormal_cardiac_muscle1.09349509
72MP0009333_abnormal_splenocyte_physiolog1.08841179
73MP0009785_altered_susceptibility_to1.08399072
74MP0003566_abnormal_cell_adhesion1.08041839
75MP0010155_abnormal_intestine_physiology1.07151155
76MP0000747_muscle_weakness1.05907498
77MP0005584_abnormal_enzyme/coenzyme_acti1.05347331
78MP0005390_skeleton_phenotype1.04468204
79MP0000678_abnormal_parathyroid_gland1.03527429
80MP0003690_abnormal_glial_cell1.03022766
81MP0005000_abnormal_immune_tolerance1.02316067
82MP0000749_muscle_degeneration1.01997044
83MP0001845_abnormal_inflammatory_respons1.01943780
84MP0002796_impaired_skin_barrier1.01399677
85MP0001545_abnormal_hematopoietic_system1.01289338
86MP0005397_hematopoietic_system_phenotyp1.01289338
87MP0003186_abnormal_redox_activity1.00883127
88MP0008438_abnormal_cutaneous_collagen1.00826281
89MP0003091_abnormal_cell_migration1.00483104
90MP0005330_cardiomyopathy1.00464493
91MP0005671_abnormal_response_to1.00418150
92MP0003329_amyloid_beta_deposits0.99708874
93MP0002723_abnormal_immune_serum0.99509922
94MP0005375_adipose_tissue_phenotype0.98856037
95MP0002452_abnormal_antigen_presenting0.98701124
96MP0001851_eye_inflammation0.98596029
97MP0002419_abnormal_innate_immunity0.98578729
98MP0004947_skin_inflammation0.96259273
99MP0009278_abnormal_bone_marrow0.96221537
100MP0004036_abnormal_muscle_relaxation0.95985348
101MP0001873_stomach_inflammation0.95294704
102MP0010352_gastrointestinal_tract_polyps0.93843013
103MP0003646_muscle_fatigue0.93673382
104MP0002398_abnormal_bone_marrow0.92842320
105MP0002405_respiratory_system_inflammati0.92646540
106MP0000689_abnormal_spleen_morphology0.92368507
107MP0002420_abnormal_adaptive_immunity0.91748288
108MP0003866_abnormal_defecation0.91598954
109MP0004808_abnormal_hematopoietic_stem0.91582748
110MP0000465_gastrointestinal_hemorrhage0.91063644
111MP0008874_decreased_physiological_sensi0.90757100
112MP0001819_abnormal_immune_cell0.90502614
113MP0000604_amyloidosis0.90031085
114MP0000703_abnormal_thymus_morphology0.89732589
115MP0002078_abnormal_glucose_homeostasis0.89001090
116MP0004264_abnormal_extraembryonic_tissu0.88954836
117MP0009763_increased_sensitivity_to0.88442346
118MP0002693_abnormal_pancreas_physiology0.88329463
119MP0002933_joint_inflammation0.88304875
120MP0008961_abnormal_basal_metabolism0.88125164
121MP0004087_abnormal_muscle_fiber0.87075156
122MP0002722_abnormal_immune_system0.87000821
123MP0003656_abnormal_erythrocyte_physiolo0.86687009
124MP0010630_abnormal_cardiac_muscle0.86374323
125MP0001879_abnormal_lymphatic_vessel0.86140501
126MP0000003_abnormal_adipose_tissue0.85970694
127MP0000750_abnormal_muscle_regeneration0.85584048
128MP0000716_abnormal_immune_system0.85328267
129MP0000767_abnormal_smooth_muscle0.85030942
130MP0005636_abnormal_mineral_homeostasis0.84774670
131MP0001944_abnormal_pancreas_morphology0.84245957
132MP0004883_abnormal_blood_vessel0.83925723
133MP0005377_hearing/vestibular/ear_phenot0.83315162
134MP0003878_abnormal_ear_physiology0.83315162
135MP0001533_abnormal_skeleton_physiology0.83166333
136MP0003868_abnormal_feces_composition0.82647582
137MP0002332_abnormal_exercise_endurance0.82429886
138MP0002429_abnormal_blood_cell0.81860577
139MP0000249_abnormal_blood_vessel0.81734505
140MP0002136_abnormal_kidney_physiology0.81541702
141MP0000759_abnormal_skeletal_muscle0.81053563
142MP0004019_abnormal_vitamin_homeostasis0.81034859
143MP0003879_abnormal_hair_cell0.80775264
144MP0001348_abnormal_lacrimal_gland0.80746114
145MP0005166_decreased_susceptibility_to0.79377974
146MP0005310_abnormal_salivary_gland0.78968764
147MP0003123_paternal_imprinting0.78198689
148MP0001663_abnormal_digestive_system0.76975935

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.49497075
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.08255284
3Recurrent abscess formation (HP:0002722)3.64790675
4Xanthomatosis (HP:0000991)3.50969324
5Abnormality of macrophages (HP:0004311)3.43637261
6Deep venous thrombosis (HP:0002625)3.42075995
7Recurrent bacterial skin infections (HP:0005406)3.40524726
8Ketosis (HP:0001946)3.28969158
9Myositis (HP:0100614)3.25353223
10Ketoacidosis (HP:0001993)3.16895297
11Intrahepatic cholestasis (HP:0001406)3.16426495
12Hypoglycemic seizures (HP:0002173)3.16226484
13Distal lower limb muscle weakness (HP:0009053)3.12494295
14Late onset (HP:0003584)3.10872892
15J-shaped sella turcica (HP:0002680)3.09641714
16Generalized aminoaciduria (HP:0002909)3.07854451
17Myoglobinuria (HP:0002913)3.04998050
18Obstructive sleep apnea (HP:0002870)3.03264783
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99657579
20Abnormality of fatty-acid metabolism (HP:0004359)2.95622386
21Cerebral aneurysm (HP:0004944)2.91461421
22Recurrent gram-negative bacterial infections (HP:0005420)2.91205667
23Hyperinsulinemic hypoglycemia (HP:0000825)2.89363957
24Hyperammonemia (HP:0001987)2.80256537
25Orchitis (HP:0100796)2.79749697
26Increased IgE level (HP:0003212)2.77044934
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76457588
28Abnormality of the intrinsic pathway (HP:0010989)2.73601187
29Broad face (HP:0000283)2.70073932
30Increased cerebral lipofuscin (HP:0011813)2.68926873
31Obstructive lung disease (HP:0006536)2.65054823
32Chronic obstructive pulmonary disease (HP:0006510)2.65054823
33Abnormality of the common coagulation pathway (HP:0010990)2.64196553
34Thin bony cortex (HP:0002753)2.64155433
35Thrombocytosis (HP:0001894)2.62005215
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54616630
37Dicarboxylic aciduria (HP:0003215)2.54616630
38Joint hemorrhage (HP:0005261)2.51114590
39Gingivitis (HP:0000230)2.50761884
40Cellulitis (HP:0100658)2.49893549
41Prolonged partial thromboplastin time (HP:0003645)2.48649594
42Hyperlipoproteinemia (HP:0010980)2.48186496
43Mediastinal lymphadenopathy (HP:0100721)2.47454864
44Gastrointestinal infarctions (HP:0005244)2.45811133
45Polygenic inheritance (HP:0010982)2.45763387
46Easy fatigability (HP:0003388)2.45417646
47Rhabdomyolysis (HP:0003201)2.42412854
48Impaired platelet aggregation (HP:0003540)2.41274261
49Abnormal platelet function (HP:0011869)2.41274261
50Colitis (HP:0002583)2.40514804
51Hypobetalipoproteinemia (HP:0003563)2.40333427
52Amyloidosis (HP:0011034)2.38742592
53Asymmetric septal hypertrophy (HP:0001670)2.38492418
54Myopathic facies (HP:0002058)2.36776183
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.36046612
56Complement deficiency (HP:0004431)2.35698393
57Cervical subluxation (HP:0003308)2.34947707
58Hemorrhage of the eye (HP:0011885)2.34558702
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.33496424
60Abnormality of glycolipid metabolism (HP:0010969)2.33496424
61Abnormality of liposaccharide metabolism (HP:0010968)2.33496424
62Bulbar palsy (HP:0001283)2.33334132
63Spontaneous hematomas (HP:0007420)2.32237743
64Abnormality of the nasal mucosa (HP:0000433)2.31689895
65Myocardial infarction (HP:0001658)2.31475792
66Polycythemia (HP:0001901)2.31174765
67Symptomatic seizures (HP:0011145)2.31144328
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.31013515
69Hyperglycinuria (HP:0003108)2.29179687
70Elevated erythrocyte sedimentation rate (HP:0003565)2.25576374
71Increased variability in muscle fiber diameter (HP:0003557)2.23954754
72Meningitis (HP:0001287)2.23437217
73Recurrent fungal infections (HP:0002841)2.21812796
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20324443
75Optic neuritis (HP:0100653)2.19669451
76Retrobulbar optic neuritis (HP:0100654)2.19669451
77Gingival bleeding (HP:0000225)2.19515513
78Abnormality of purine metabolism (HP:0004352)2.19233979
79Distal lower limb amyotrophy (HP:0008944)2.17949237
80Hyperbilirubinemia (HP:0002904)2.17421929
81Hypoalphalipoproteinemia (HP:0003233)2.17299075
82Chest pain (HP:0100749)2.16690812
83Hypolipoproteinemia (HP:0010981)2.14975527
84Abnormality of skeletal muscle fiber size (HP:0012084)2.14753197
85Insulin resistance (HP:0000855)2.12705576
86Recurrent skin infections (HP:0001581)2.10953860
87Loss of speech (HP:0002371)2.08991241
88Hyperacusis (HP:0010780)2.07602177
89Metaphyseal cupping (HP:0003021)2.07114926
90Axonal loss (HP:0003447)2.05469559
91Ventricular tachycardia (HP:0004756)2.05206864
92Gout (HP:0001997)2.05082422
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05054100
94Abnormality of complement system (HP:0005339)2.02916157
95Exercise-induced muscle cramps (HP:0003710)2.02797639
96Protrusio acetabuli (HP:0003179)2.02737222
97Increased connective tissue (HP:0009025)2.02532123
98Mucopolysacchariduria (HP:0008155)2.02430011
99Urinary glycosaminoglycan excretion (HP:0003541)2.02430011
100Nasal polyposis (HP:0100582)2.02404831
101Purpura (HP:0000979)2.02324578
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02287502
103Epistaxis (HP:0000421)2.01934005
104Abnormality of glycine metabolism (HP:0010895)2.01520732
105Abnormality of serine family amino acid metabolism (HP:0010894)2.01520732
106Muscle fiber splitting (HP:0003555)2.01071205
107Peritonitis (HP:0002586)1.99184913
108Stridor (HP:0010307)1.97747015
109Neuronal loss in central nervous system (HP:0002529)1.96497345
110Difficulty running (HP:0009046)1.96058913
111Joint stiffness (HP:0001387)1.95444345
112Pustule (HP:0200039)1.95040220
113Abnormality of the thoracic spine (HP:0100711)1.94641345
114Increased serum ferritin (HP:0003281)1.94631736
115Abnormality of T cell physiology (HP:0011840)1.94442998
116Esophageal varix (HP:0002040)1.94216892
117Thoracic kyphosis (HP:0002942)1.94144937
118Systemic lupus erythematosus (HP:0002725)1.93701477
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.93132430
120Ulnar deviation of the wrist (HP:0003049)1.92807306
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.92530613
122Abnormality of the pancreatic islet cells (HP:0006476)1.92493317
123Abnormality of endocrine pancreas physiology (HP:0012093)1.92493317
124Metabolic acidosis (HP:0001942)1.92103446
125Menorrhagia (HP:0000132)1.91850978
126Abnormality of nucleobase metabolism (HP:0010932)1.91541689
127Increased muscle lipid content (HP:0009058)1.91334499
128Hyporeflexia of lower limbs (HP:0002600)1.90872228
129Hypercholesterolemia (HP:0003124)1.89997626
130IgM deficiency (HP:0002850)1.89507806
131Vertebral compression fractures (HP:0002953)1.89353230
132Abnormality of iron homeostasis (HP:0011031)1.88232735
133Interstitial pulmonary disease (HP:0006530)1.86972430
134Vacuolated lymphocytes (HP:0001922)1.86332089
135Gastrointestinal inflammation (HP:0004386)1.85895802
136Deformed sella turcica (HP:0002681)1.85282618
137Eczematoid dermatitis (HP:0000976)1.84552362
138Emphysema (HP:0002097)1.84154592
139Exercise-induced myalgia (HP:0003738)1.83195396
140Hyperglycemia (HP:0003074)1.82483707
141Chronic otitis media (HP:0000389)1.82080508
142Vasculitis (HP:0002633)1.81218817
143Inflammation of the large intestine (HP:0002037)1.81097316
144Difficulty climbing stairs (HP:0003551)1.81052589
145Malnutrition (HP:0004395)1.80994207
146Abnormality of transition element cation homeostasis (HP:0011030)1.80977237
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80185135
148Nuclear cataract (HP:0100018)1.80017796
149Multiple enchondromatosis (HP:0005701)1.79470347
150Prolonged bleeding time (HP:0003010)1.79456578
151Hepatic necrosis (HP:0002605)1.79099500
152Petechiae (HP:0000967)1.78510191
153Mitral regurgitation (HP:0001653)1.78182233
154Type 1 muscle fiber predominance (HP:0003803)1.77627513
155Growth hormone excess (HP:0000845)1.77587178
156Segmental peripheral demyelination/remyelination (HP:0003481)1.75854299
157Aneurysm (HP:0002617)1.75825276
158Lymphangioma (HP:0100764)1.75711689
159Restrictive lung disease (HP:0002091)1.75566411
160Hematochezia (HP:0002573)1.75234053
161Large for gestational age (HP:0001520)1.75110922
162Arterial thrombosis (HP:0004420)1.75080675
163Abnormality of polysaccharide metabolism (HP:0011012)1.73713138
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73713138
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73713138
166Hypercortisolism (HP:0001578)1.73676238
167Microcytic anemia (HP:0001935)1.71440858
168Fat malabsorption (HP:0002630)1.70471138
169Pancreatitis (HP:0001733)1.70470494
170Hypertriglyceridemia (HP:0002155)1.70339775
171Epidermoid cyst (HP:0200040)1.70317792
172Pancreatic islet-cell hyperplasia (HP:0004510)1.69983730
173Autoimmune thrombocytopenia (HP:0001973)1.69653127
174Dysostosis multiplex (HP:0000943)1.69629240
175Lipoatrophy (HP:0100578)1.69587513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.19304822
2PKN23.38301737
3ERN13.34377434
4MAP4K13.02783781
5BCKDK3.01373107
6PRPF4B2.84400110
7SMG12.81459289
8NME22.32960629
9FLT32.29545514
10RIPK42.27455501
11EEF2K2.12017442
12MAP3K102.10759602
13TTN2.09847973
14TAOK32.05805204
15FGFR42.02096153
16TNK22.01664889
17KDR1.87102850
18SIK11.86550298
19ZAP701.84120102
20MAP2K31.83356575
21TYK21.81288915
22TBK11.79159655
23PTK61.75497230
24JAK31.71988386
25TGFBR21.63064271
26LRRK21.57597762
27SIK21.49097011
28BTK1.48563027
29TIE11.46068662
30MARK21.45120835
31ICK1.44315694
32EPHB11.40558068
33PASK1.38332072
34PRKD21.33781744
35MAP3K131.33044094
36SIK31.32399185
37FES1.29938044
38BLK1.25862232
39PIK3CG1.25486688
40NEK91.24227620
41CDC42BPA1.23948272
42KIT1.20873253
43RIPK11.13184116
44SCYL21.09478316
45TGFBR11.07689031
46IRAK31.07243352
47INSRR1.06359383
48RPS6KA41.04408908
49IKBKE1.04078547
50EPHA21.01920830
51PDPK11.00692947
52MAP3K60.99455620
53HIPK20.98563530
54RPS6KA20.98487558
55TESK10.97395977
56JAK10.96324554
57STK100.94988242
58TAOK20.93406009
59IRAK20.92648835
60ITK0.90697041
61MAPK110.90070189
62MUSK0.90029990
63CSF1R0.89928462
64MAP3K70.87622695
65JAK20.87009786
66GRK60.86413817
67PIM20.86006116
68TEC0.83246621
69CSK0.82008015
70CDK40.81108272
71CAMKK10.79893123
72OBSCN0.79776073
73MAPKAPK30.78506012
74MAP3K110.77968327
75MAP2K20.76736175
76MAP3K30.75520678
77TESK20.75331988
78PAK40.74491302
79RPS6KB20.72502034
80IRAK40.72446146
81NLK0.72000521
82IKBKB0.71080290
83KSR20.71040957
84ILK0.70611153
85SYK0.69898880
86MAPK70.68529227
87LMTK20.67051173
88DYRK1B0.66559827
89TYRO30.66453128
90EPHA30.66139422
91CAMK1D0.65669330
92LCK0.65487692
93PRKD30.65302619
94RET0.64038261
95CDK120.62191109
96BMX0.61746124
97DMPK0.61215656
98FGFR30.60136104
99PIM10.60051717
100FGR0.59921631
101NEK20.59300024
102CDK60.57134361
103MAPK150.56695423
104PRKG20.56665881
105MAP3K80.56546481
106HCK0.55785849
107MAP3K140.53517272
108PRKAA20.52797909
109MTOR0.52078283
110STK380.52038445
111MAP2K60.50639864
112CHUK0.49726157
113PDGFRA0.48693251
114MAP3K10.48052962
115MYLK0.47753685
116IRAK10.47134692
117PAK20.44970977
118MST1R0.44243460
119STK40.43969565
120ARAF0.43856219
121MAPKAPK20.43703847
122TXK0.43214743
123MARK30.41740286
124RPS6KA60.40068738
125FYN0.39601094
126LYN0.39591983
127PRKD10.39308150
128MAPK120.37970957
129MAPK40.37229634
130SGK30.37222153
131RPS6KA10.34885147
132RPS6KC10.33941893
133RPS6KL10.33941893
134PTK20.33767678
135PDK10.33363940
136CAMK1G0.32727808
137TAOK10.31025060

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.72339553
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.50404344
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.43417362
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40684472
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37809330
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37327642
7Nitrogen metabolism_Homo sapiens_hsa009102.27985437
8Tryptophan metabolism_Homo sapiens_hsa003802.21499782
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08672298
10Propanoate metabolism_Homo sapiens_hsa006402.04254026
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02167873
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92831051
13Selenocompound metabolism_Homo sapiens_hsa004501.90504973
14Notch signaling pathway_Homo sapiens_hsa043301.86740693
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84376929
16Folate biosynthesis_Homo sapiens_hsa007901.75025820
17Arginine biosynthesis_Homo sapiens_hsa002201.72169637
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69597551
19Fatty acid metabolism_Homo sapiens_hsa012121.67649324
20VEGF signaling pathway_Homo sapiens_hsa043701.66850271
21Complement and coagulation cascades_Homo sapiens_hsa046101.65097158
22PPAR signaling pathway_Homo sapiens_hsa033201.60356114
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58621125
24Peroxisome_Homo sapiens_hsa041461.57373267
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54150805
26Caffeine metabolism_Homo sapiens_hsa002321.53873749
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53509555
28Sulfur relay system_Homo sapiens_hsa041221.52628208
29Carbon metabolism_Homo sapiens_hsa012001.51303394
30Non-small cell lung cancer_Homo sapiens_hsa052231.48362956
31Starch and sucrose metabolism_Homo sapiens_hsa005001.45152347
32Staphylococcus aureus infection_Homo sapiens_hsa051501.42623203
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.41331884
34beta-Alanine metabolism_Homo sapiens_hsa004101.40479933
35Tuberculosis_Homo sapiens_hsa051521.39001205
36Lysine degradation_Homo sapiens_hsa003101.33003506
37Ribosome_Homo sapiens_hsa030101.31372926
38One carbon pool by folate_Homo sapiens_hsa006701.31021444
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28368074
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27146429
41Butanoate metabolism_Homo sapiens_hsa006501.26976022
42Hepatitis C_Homo sapiens_hsa051601.24564225
43Endometrial cancer_Homo sapiens_hsa052131.23715536
44Pyruvate metabolism_Homo sapiens_hsa006201.22604645
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.21423274
46T cell receptor signaling pathway_Homo sapiens_hsa046601.21267980
47ABC transporters_Homo sapiens_hsa020101.21056576
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17603653
49Histidine metabolism_Homo sapiens_hsa003401.16216122
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15895467
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14210192
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.13846052
53Biosynthesis of amino acids_Homo sapiens_hsa012301.12796615
54Chemokine signaling pathway_Homo sapiens_hsa040621.12794552
55Fat digestion and absorption_Homo sapiens_hsa049751.11596865
56TNF signaling pathway_Homo sapiens_hsa046681.11043279
57Sulfur metabolism_Homo sapiens_hsa009201.10763509
58Pancreatic cancer_Homo sapiens_hsa052121.09823869
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08948417
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08470914
61Insulin signaling pathway_Homo sapiens_hsa049101.07981020
62Influenza A_Homo sapiens_hsa051641.07715479
63Renal cell carcinoma_Homo sapiens_hsa052111.07605353
64Insulin resistance_Homo sapiens_hsa049311.07428133
65mTOR signaling pathway_Homo sapiens_hsa041501.07337302
66GnRH signaling pathway_Homo sapiens_hsa049121.05307538
67Pentose phosphate pathway_Homo sapiens_hsa000301.03351071
68Choline metabolism in cancer_Homo sapiens_hsa052311.02768986
69Malaria_Homo sapiens_hsa051441.02085297
70Allograft rejection_Homo sapiens_hsa053301.01946391
71Other glycan degradation_Homo sapiens_hsa005110.99809214
72Amoebiasis_Homo sapiens_hsa051460.99083037
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.99001542
74Phenylalanine metabolism_Homo sapiens_hsa003600.97361129
75Primary immunodeficiency_Homo sapiens_hsa053400.97302563
76Graft-versus-host disease_Homo sapiens_hsa053320.96806835
77Galactose metabolism_Homo sapiens_hsa000520.96460212
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.94303188
79Bladder cancer_Homo sapiens_hsa052190.93540085
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93314107
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93107955
82Platelet activation_Homo sapiens_hsa046110.92649656
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92369527
84Endocytosis_Homo sapiens_hsa041440.92247303
85DNA replication_Homo sapiens_hsa030300.91572161
86Hepatitis B_Homo sapiens_hsa051610.91090888
87Prolactin signaling pathway_Homo sapiens_hsa049170.90993866
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90343601
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89806886
90Autoimmune thyroid disease_Homo sapiens_hsa053200.89691938
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89502403
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.89386073
93Pertussis_Homo sapiens_hsa051330.89298004
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89269791
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89154666
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.89052777
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88316331
98Protein export_Homo sapiens_hsa030600.88114068
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.86277558
100Estrogen signaling pathway_Homo sapiens_hsa049150.85920692
101ErbB signaling pathway_Homo sapiens_hsa040120.84910852
102Chemical carcinogenesis_Homo sapiens_hsa052040.83651220
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83329675
104Antigen processing and presentation_Homo sapiens_hsa046120.82324400
105Inositol phosphate metabolism_Homo sapiens_hsa005620.80361647
106Prion diseases_Homo sapiens_hsa050200.76836008
107Arginine and proline metabolism_Homo sapiens_hsa003300.76072957
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.75865208
109Salmonella infection_Homo sapiens_hsa051320.75774827
110Bile secretion_Homo sapiens_hsa049760.75677898
111Fatty acid elongation_Homo sapiens_hsa000620.75636424
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75136697
113Glioma_Homo sapiens_hsa052140.74538893
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74476957
115Phagosome_Homo sapiens_hsa041450.73487302
116Colorectal cancer_Homo sapiens_hsa052100.72800386
117Thyroid cancer_Homo sapiens_hsa052160.72041560
118Apoptosis_Homo sapiens_hsa042100.71403491
119Acute myeloid leukemia_Homo sapiens_hsa052210.71180066
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.70716379
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70642563
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68574118
123MAPK signaling pathway_Homo sapiens_hsa040100.68111855
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67851544
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66989399
126Tyrosine metabolism_Homo sapiens_hsa003500.66583710
127Leishmaniasis_Homo sapiens_hsa051400.64955508
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64472218
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.63282862
130B cell receptor signaling pathway_Homo sapiens_hsa046620.62413511
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62085526
132HIF-1 signaling pathway_Homo sapiens_hsa040660.60896788
133Retinol metabolism_Homo sapiens_hsa008300.60370250
134Shigellosis_Homo sapiens_hsa051310.60171616
135Focal adhesion_Homo sapiens_hsa045100.59739648
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59583208
137HTLV-I infection_Homo sapiens_hsa051660.58751628
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.58676648
139FoxO signaling pathway_Homo sapiens_hsa040680.58225088
140Rap1 signaling pathway_Homo sapiens_hsa040150.54974331
141Vitamin digestion and absorption_Homo sapiens_hsa049770.54918573
142Glycerolipid metabolism_Homo sapiens_hsa005610.54291455
143Measles_Homo sapiens_hsa051620.53040468
144Proteoglycans in cancer_Homo sapiens_hsa052050.52195005
145Legionellosis_Homo sapiens_hsa051340.48413803
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48041646
147Osteoclast differentiation_Homo sapiens_hsa043800.47414378
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47110854
149Fructose and mannose metabolism_Homo sapiens_hsa000510.46117219
150N-Glycan biosynthesis_Homo sapiens_hsa005100.45518052
151Toxoplasmosis_Homo sapiens_hsa051450.44992271
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.44945443
153Viral myocarditis_Homo sapiens_hsa054160.44802832
154Lysosome_Homo sapiens_hsa041420.42929307
155AMPK signaling pathway_Homo sapiens_hsa041520.42592459
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42552688
157Mismatch repair_Homo sapiens_hsa034300.42402458
158Chronic myeloid leukemia_Homo sapiens_hsa052200.40942032
159Herpes simplex infection_Homo sapiens_hsa051680.40078084
160Glutathione metabolism_Homo sapiens_hsa004800.40034044
161Leukocyte transendothelial migration_Homo sapiens_hsa046700.39325761
162Hematopoietic cell lineage_Homo sapiens_hsa046400.38919227
163Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38437684
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38269437
165Small cell lung cancer_Homo sapiens_hsa052220.38125632
166Intestinal immune network for IgA production_Homo sapiens_hsa046720.36459523
167Base excision repair_Homo sapiens_hsa034100.36352304
168Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32968027

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