NPEPPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.06957776
2polyketide metabolic process (GO:0030638)8.06957776
3doxorubicin metabolic process (GO:0044598)8.06957776
4maintenance of protein location in nucleus (GO:0051457)5.32809092
5aminoglycoside antibiotic metabolic process (GO:0030647)5.05207262
6somite rostral/caudal axis specification (GO:0032525)4.99340340
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.75809763
8negative regulation of epidermis development (GO:0045683)4.60305979
9histone H4-K12 acetylation (GO:0043983)4.58988063
10synaptic vesicle maturation (GO:0016188)4.51049324
11histone H4-K8 acetylation (GO:0043982)4.50235386
12histone H4-K5 acetylation (GO:0043981)4.50235386
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.49035125
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.38665106
15negative regulation of telomerase activity (GO:0051974)4.28294267
16regulation of response to osmotic stress (GO:0047484)4.25834183
17proline transport (GO:0015824)4.21820505
18regulation of telomere maintenance via telomerase (GO:0032210)4.21793107
19notochord development (GO:0030903)4.05464963
20heterochromatin organization (GO:0070828)4.01257010
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.90004455
22phenol-containing compound catabolic process (GO:0019336)3.89420184
23regulation of MHC class I biosynthetic process (GO:0045343)3.86045635
24negative regulation of cell cycle G2/M phase transition (GO:1902750)3.76876123
25muscle organ morphogenesis (GO:0048644)3.72941746
26negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.72817297
27desmosome organization (GO:0002934)3.65733834
28branching involved in mammary gland duct morphogenesis (GO:0060444)3.60362073
29protein localization to kinetochore (GO:0034501)3.59694466
30regulation of cilium movement (GO:0003352)3.50375460
31response to dietary excess (GO:0002021)3.45618910
32cell fate commitment involved in formation of primary germ layer (GO:0060795)3.44769970
33negative regulation of epidermal cell differentiation (GO:0045605)3.41431136
34histone H4-K16 acetylation (GO:0043984)3.41262312
35cardiovascular system development (GO:0072358)3.38522834
36mitotic sister chromatid segregation (GO:0000070)3.38410148
37pre-miRNA processing (GO:0031054)3.34719867
38cytoplasmic mRNA processing body assembly (GO:0033962)3.31846936
39cytidine deamination (GO:0009972)3.26323986
40cytidine metabolic process (GO:0046087)3.26323986
41cytidine catabolic process (GO:0006216)3.26323986
42regulation of apoptotic process involved in morphogenesis (GO:1902337)3.23701830
43plasma membrane repair (GO:0001778)3.20052358
44mitochondrion distribution (GO:0048311)3.20007124
45primitive streak formation (GO:0090009)3.18278747
46negative regulation of potassium ion transmembrane transport (GO:1901380)3.18110236
47detection of temperature stimulus (GO:0016048)3.17908854
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16022540
49negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.13608748
50intestinal epithelial cell development (GO:0060576)3.12567784
51rRNA transcription (GO:0009303)3.06248265
52calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01604127
53mitotic sister chromatid cohesion (GO:0007064)3.01180962
54regulation of telomere maintenance (GO:0032204)3.00966277
55positive regulation of DNA-dependent DNA replication (GO:2000105)3.00888878
56establishment of nucleus localization (GO:0040023)3.00779748
57bone trabecula formation (GO:0060346)3.00466938
58regulation of RNA export from nucleus (GO:0046831)2.93047683
59cytoskeletal anchoring at plasma membrane (GO:0007016)2.90570888
60apical protein localization (GO:0045176)2.88310216
61regulation of clathrin-mediated endocytosis (GO:2000369)2.87902060
62chromatin assembly (GO:0031497)2.87844469
63sister chromatid segregation (GO:0000819)2.86741799
64regulation of gene silencing by RNA (GO:0060966)2.83580580
65regulation of posttranscriptional gene silencing (GO:0060147)2.83580580
66regulation of gene silencing by miRNA (GO:0060964)2.83580580
67maintenance of protein localization in organelle (GO:0072595)2.83138551
68cell migration in hindbrain (GO:0021535)2.82207337
69hippo signaling (GO:0035329)2.81837530
70regulation of microtubule-based movement (GO:0060632)2.81623465
71regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.80506995
72paraxial mesoderm development (GO:0048339)2.79644586
73negative regulation of telomere maintenance (GO:0032205)2.79594132
74intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.79515268
75ventricular system development (GO:0021591)2.79266570
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79217363
77nucleoside transmembrane transport (GO:1901642)2.77558235
78NLS-bearing protein import into nucleus (GO:0006607)2.74765501
79intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.71079799
80regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68295710
81asymmetric protein localization (GO:0008105)2.67039744
82regulation of transforming growth factor beta2 production (GO:0032909)2.66908318
83regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.66595668
84tachykinin receptor signaling pathway (GO:0007217)2.66563668
85planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65727655
86nuclear pore complex assembly (GO:0051292)2.65727524
87anterior/posterior axis specification (GO:0009948)2.65235941
88glutamate secretion (GO:0014047)2.65192047
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64169674
90positive regulation of histone deacetylation (GO:0031065)2.62166436
91protein localization to microtubule (GO:0035372)2.61665205
92embryonic axis specification (GO:0000578)2.59298681
93protein polyglutamylation (GO:0018095)2.56467540
94regulation of hippo signaling (GO:0035330)2.55825716
95cell migration involved in gastrulation (GO:0042074)2.55588062
96hypotonic response (GO:0006971)2.54524361
97myotube differentiation (GO:0014902)2.53558988
98microtubule severing (GO:0051013)2.51351039
99histone arginine methylation (GO:0034969)2.50441427
100nucleus localization (GO:0051647)2.50350806
101protein localization to chromosome, centromeric region (GO:0071459)2.47718189
102positive regulation of protein deacetylation (GO:0090312)2.47653210
103embryonic foregut morphogenesis (GO:0048617)2.47187398
104trophectodermal cell differentiation (GO:0001829)2.47043891
105hormone catabolic process (GO:0042447)2.46532352
106anterior/posterior axis specification, embryo (GO:0008595)2.46251921
107RNA stabilization (GO:0043489)2.46081238
108mRNA stabilization (GO:0048255)2.46081238
109negative regulation of smoothened signaling pathway (GO:0045879)2.45516692
110myelination in peripheral nervous system (GO:0022011)2.44405838
111peripheral nervous system axon ensheathment (GO:0032292)2.44405838
112regulation of telomerase activity (GO:0051972)2.41743347
113regulation of establishment of planar polarity (GO:0090175)2.41689511
114Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41588310
115histone H3-K4 methylation (GO:0051568)2.41409399
116pyrimidine ribonucleoside catabolic process (GO:0046133)2.41144140
117cell communication involved in cardiac conduction (GO:0086065)2.40646907
118negative regulation of keratinocyte proliferation (GO:0010839)2.38912674
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.38297312
120protein localization to synapse (GO:0035418)2.37700134
121icosanoid secretion (GO:0032309)2.36854924
122arachidonic acid secretion (GO:0050482)2.36854924
123morphogenesis of an epithelial sheet (GO:0002011)2.36803869
124regulation of nucleobase-containing compound transport (GO:0032239)2.35968927
125phosphatidylinositol 3-kinase signaling (GO:0014065)2.35745856
126interferon-gamma production (GO:0032609)2.34713406
127cerebral cortex development (GO:0021987)2.34373753
128mating behavior (GO:0007617)2.33800593
129branching involved in labyrinthine layer morphogenesis (GO:0060670)2.33043067
130stress granule assembly (GO:0034063)2.32894927
131neuron recognition (GO:0008038)2.31712920
132axonal fasciculation (GO:0007413)2.30448207
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.26885154
134establishment of planar polarity (GO:0001736)2.26780809
135establishment of tissue polarity (GO:0007164)2.26780809
136neuronal action potential propagation (GO:0019227)2.25972097
137nuclear pore organization (GO:0006999)2.25220412
138glucocorticoid receptor signaling pathway (GO:0042921)2.23838100
139histone H3-K9 demethylation (GO:0033169)2.23725561
140regulation of DNA endoreduplication (GO:0032875)2.22812759
141peptidyl-lysine dimethylation (GO:0018027)2.22362531
142regulation of axon extension involved in axon guidance (GO:0048841)2.21781364
143dendrite morphogenesis (GO:0048813)2.20675983
144protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.20639167
145myoblast fusion (GO:0007520)2.19970232
146camera-type eye morphogenesis (GO:0048593)2.19097624
147layer formation in cerebral cortex (GO:0021819)2.19018445
148cerebral cortex radially oriented cell migration (GO:0021799)2.18652182
149postsynaptic membrane organization (GO:0001941)2.18396237
150regulation of NFAT protein import into nucleus (GO:0051532)2.16779665
151regulation of axon guidance (GO:1902667)2.16657585
152convergent extension (GO:0060026)2.16316453
153central nervous system projection neuron axonogenesis (GO:0021952)2.15036480
154gastrulation with mouth forming second (GO:0001702)2.12745257
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.11584537
156ectodermal placode formation (GO:0060788)2.10839189
157genitalia morphogenesis (GO:0035112)2.10323900
158adherens junction assembly (GO:0034333)2.09815476
159neuromuscular junction development (GO:0007528)2.09051087
160auditory behavior (GO:0031223)2.08585879
161polarized epithelial cell differentiation (GO:0030859)2.06138871
162face development (GO:0060324)2.05964921
163focal adhesion assembly (GO:0048041)2.04330844
164cell-substrate adherens junction assembly (GO:0007045)2.04330844
165cochlea morphogenesis (GO:0090103)2.03049661
166axon extension (GO:0048675)2.02533672
167carnitine shuttle (GO:0006853)2.01747976
168vesicle transport along microtubule (GO:0047496)2.01444603
169cell morphogenesis involved in neuron differentiation (GO:0048667)2.01152466
170presynaptic membrane assembly (GO:0097105)2.01140615
171clathrin coat assembly (GO:0048268)2.00937019
172sympathetic nervous system development (GO:0048485)2.00755810
173central nervous system neuron axonogenesis (GO:0021955)2.00716218
174regulation of fatty acid beta-oxidation (GO:0031998)2.00167668
175regulation of cardioblast differentiation (GO:0051890)2.00108916
176ventricular cardiac muscle cell action potential (GO:0086005)1.99380613
177spinal cord development (GO:0021510)1.98580662
178proximal/distal pattern formation (GO:0009954)1.98374039
179ear development (GO:0043583)1.97221469
180positive regulation of dendrite morphogenesis (GO:0050775)1.96247509
181adherens junction organization (GO:0034332)1.95234809
182ephrin receptor signaling pathway (GO:0048013)1.94866711
183lateral sprouting from an epithelium (GO:0060601)1.94771276
184suckling behavior (GO:0001967)1.94605732
185ectoderm development (GO:0007398)1.94423601
186nephron tubule formation (GO:0072079)1.93645781
187non-canonical Wnt signaling pathway (GO:0035567)1.92100213
188histone H3-K36 demethylation (GO:0070544)1.91501372
189body morphogenesis (GO:0010171)1.90738077
190inositol metabolic process (GO:0006020)1.90176265
191COPII vesicle coating (GO:0048208)1.89593753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.27837899
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.27837899
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.27837899
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.16854819
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.46858848
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.20566239
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19914649
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.13609139
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.09699722
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.87607152
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.56376619
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.51908755
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.50475835
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46595210
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43128206
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.38240160
17GBX2_23144817_ChIP-Seq_PC3_Human2.31163893
18EZH2_22144423_ChIP-Seq_EOC_Human2.30130542
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20392210
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19119585
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16755436
22* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.14575618
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.14259201
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13763213
25* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.12980110
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10855801
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10341760
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99231829
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97963813
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96585769
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96286176
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.88621884
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.88542091
34* AHR_22903824_ChIP-Seq_MCF-7_Human1.86088531
35TAF15_26573619_Chip-Seq_HEK293_Human1.84182624
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.83425172
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.81987810
38TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.81789587
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.78995111
40* ARNT_22903824_ChIP-Seq_MCF-7_Human1.70709211
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.65617385
42AR_21909140_ChIP-Seq_LNCAP_Human1.63043367
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61083795
44TP53_16413492_ChIP-PET_HCT116_Human1.60550507
45* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.59927620
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.57092667
47* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.55542321
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53290116
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.52423500
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52362996
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.50041105
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45547814
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44888871
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44668500
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42580061
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42580061
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.42196999
58AR_21572438_ChIP-Seq_LNCaP_Human1.41763448
59* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40513578
60RNF2_27304074_Chip-Seq_NSC_Mouse1.39915525
61* ISL1_27105846_Chip-Seq_CPCs_Mouse1.39506404
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39191716
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39159648
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.37265481
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36728908
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.36535510
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35011008
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34695457
69KDM2B_26808549_Chip-Seq_K562_Human1.34262427
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32642412
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.31084585
72* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29846098
73SMAD4_21799915_ChIP-Seq_A2780_Human1.29242555
74* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.27951103
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27049529
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26563377
77E2F1_17053090_ChIP-ChIP_MCF-7_Human1.26216854
78* STAT3_23295773_ChIP-Seq_U87_Human1.26136184
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25817174
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.25557498
81* NANOG_16518401_ChIP-PET_MESCs_Mouse1.25258603
82* REST_21632747_ChIP-Seq_MESCs_Mouse1.24865567
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.24371767
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23733002
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23316306
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23243177
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22802319
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22242577
89FUS_26573619_Chip-Seq_HEK293_Human1.22241722
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22052192
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.22034375
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21962370
93* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19896638
94* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18067818
95* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18059154
96* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18059154
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17368402
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.17280116
99* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16502582
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16323624
101* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16305665
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.14046861
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12471555
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11326885
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11315391
106IRF1_19129219_ChIP-ChIP_H3396_Human1.11048876
107FOXM1_23109430_ChIP-Seq_U2OS_Human1.10960617
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.10245845
109* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09115185
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08544417
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08189664
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06616093
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05801032
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05745850
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05676319
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05431343
117AR_19668381_ChIP-Seq_PC3_Human1.05293800
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05067330
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05022200
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.04696593
121* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04512331
122TCF4_23295773_ChIP-Seq_U87_Human1.02856943
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.02764781
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01175657
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00954876
126JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00733790
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00702755
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99581259
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.99086008
130* SOX9_26525672_Chip-Seq_HEART_Mouse0.99059128
131ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98988662
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96841578
133IGF1R_20145208_ChIP-Seq_DFB_Human0.96572436
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96544902
135RXR_22108803_ChIP-Seq_LS180_Human0.95975905
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95689325
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95607400
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95378437
139* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95176075
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.94536499
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.94430906
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94177408
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93856356
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93599850
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92973340
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92959032
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91545432
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90389481
149TP53_22127205_ChIP-Seq_IMR90_Human0.88794993
150RING1B_27294783_Chip-Seq_ESCs_Mouse0.88553069
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88340482
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86537808
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85734296
154WT1_19549856_ChIP-ChIP_CCG9911_Human0.85487476
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84404566
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84399113
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84329577
158NANOG_21062744_ChIP-ChIP_HESCs_Human0.83184166
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.82743922
160CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82381523
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82245931
162* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82147643
163NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81820092
164KLF5_25053715_ChIP-Seq_YYC3_Human0.81427565
165SMC4_20622854_ChIP-Seq_HELA_Human0.80409227
166NANOG_16153702_ChIP-ChIP_HESCs_Human0.80348029
167SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78262102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system3.55937077
2MP0006292_abnormal_olfactory_placode3.51931410
3MP0003890_abnormal_embryonic-extraembry2.95746253
4MP0005394_taste/olfaction_phenotype2.94408436
5MP0005499_abnormal_olfactory_system2.94408436
6MP0003122_maternal_imprinting2.92357738
7MP0004264_abnormal_extraembryonic_tissu2.89499895
8MP0002254_reproductive_system_inflammat2.86414499
9MP0010234_abnormal_vibrissa_follicle2.85071812
10MP0003011_delayed_dark_adaptation2.74706712
11MP0004859_abnormal_synaptic_plasticity2.43099894
12MP0002653_abnormal_ependyma_morphology2.38708211
13MP0001346_abnormal_lacrimal_gland2.30330269
14MP0003787_abnormal_imprinting2.21300712
15MP0003121_genomic_imprinting2.19585823
16MP0004270_analgesia2.19257066
17MP0010678_abnormal_skin_adnexa2.08111534
18MP0000383_abnormal_hair_follicle1.94788683
19MP0005257_abnormal_intraocular_pressure1.90167634
20MP0005409_darkened_coat_color1.85550429
21MP0003283_abnormal_digestive_organ1.84443933
22MP0000537_abnormal_urethra_morphology1.84328569
23MP0000427_abnormal_hair_cycle1.81351440
24MP0002332_abnormal_exercise_endurance1.80201949
25MP0003938_abnormal_ear_development1.74201651
26MP0008961_abnormal_basal_metabolism1.66926836
27MP0000678_abnormal_parathyroid_gland1.64923176
28MP0004233_abnormal_muscle_weight1.64522898
29MP0004145_abnormal_muscle_electrophysio1.64487977
30MP0010030_abnormal_orbit_morphology1.62007032
31MP0000569_abnormal_digit_pigmentation1.61365621
32MP0003635_abnormal_synaptic_transmissio1.56470575
33MP0003880_abnormal_central_pattern1.56309464
34MP0005187_abnormal_penis_morphology1.56190156
35MP0005623_abnormal_meninges_morphology1.50730382
36MP0000579_abnormal_nail_morphology1.50065184
37MP0009046_muscle_twitch1.49269127
38MP0003942_abnormal_urinary_system1.48768144
39MP0000534_abnormal_ureter_morphology1.48111715
40MP0005075_abnormal_melanosome_morpholog1.45797512
41MP0003937_abnormal_limbs/digits/tail_de1.44986982
42MP0003183_abnormal_peptide_metabolism1.43952119
43MP0000647_abnormal_sebaceous_gland1.43388563
44MP0010352_gastrointestinal_tract_polyps1.43126307
45MP0001486_abnormal_startle_reflex1.42436017
46MP0003705_abnormal_hypodermis_morpholog1.41784845
47MP0008057_abnormal_DNA_replication1.41778214
48MP0000049_abnormal_middle_ear1.41599795
49MP0001348_abnormal_lacrimal_gland1.41242975
50MP0008789_abnormal_olfactory_epithelium1.36649894
51MP0002063_abnormal_learning/memory/cond1.36101909
52MP0000762_abnormal_tongue_morphology1.35285556
53MP0000778_abnormal_nervous_system1.35106482
54MP0005076_abnormal_cell_differentiation1.31391230
55MP0003385_abnormal_body_wall1.28735844
56* MP0002572_abnormal_emotion/affect_behav1.28486597
57MP0004133_heterotaxia1.28286690
58MP0001299_abnormal_eye_distance/1.27941925
59MP0002734_abnormal_mechanical_nocicepti1.27743137
60MP0000955_abnormal_spinal_cord1.26599622
61MP0002697_abnormal_eye_size1.26141431
62MP0003119_abnormal_digestive_system1.24411008
63MP0003137_abnormal_impulse_conducting1.23057254
64MP0003755_abnormal_palate_morphology1.21544650
65MP0003123_paternal_imprinting1.21165106
66MP0002127_abnormal_cardiovascular_syste1.21042179
67MP0002098_abnormal_vibrissa_morphology1.20930907
68MP0001849_ear_inflammation1.20515292
69MP0003115_abnormal_respiratory_system1.20368750
70MP0002064_seizures1.20283630
71MP0003950_abnormal_plasma_membrane1.19710850
72MP0002277_abnormal_respiratory_mucosa1.16707631
73MP0002184_abnormal_innervation1.16075947
74MP0002233_abnormal_nose_morphology1.14838512
75MP0002909_abnormal_adrenal_gland1.13943645
76MP0004957_abnormal_blastocyst_morpholog1.11570919
77MP0006035_abnormal_mitochondrial_morpho1.11145593
78MP0000566_synostosis1.10561166
79MP0005248_abnormal_Harderian_gland1.10164824
80MP0002751_abnormal_autonomic_nervous1.09961368
81MP0001293_anophthalmia1.07587533
82MP0001286_abnormal_eye_development1.07558893
83MP0003566_abnormal_cell_adhesion1.07107835
84MP0001672_abnormal_embryogenesis/_devel1.06553668
85MP0005380_embryogenesis_phenotype1.06553668
86MP0000428_abnormal_craniofacial_morphol1.06142895
87MP0000733_abnormal_muscle_development1.06117290
88MP0000751_myopathy1.04268623
89MP0006072_abnormal_retinal_apoptosis1.03301820
90MP0003861_abnormal_nervous_system1.03027411
91MP0000432_abnormal_head_morphology1.02804773
92MP0009745_abnormal_behavioral_response1.02149616
93MP0003935_abnormal_craniofacial_develop1.01452351
94MP0002114_abnormal_axial_skeleton1.00746092
95MP0005275_abnormal_skin_tensile1.00616409
96MP0002932_abnormal_joint_morphology1.00217175
97MP0009780_abnormal_chondrocyte_physiolo0.99520325
98MP0000749_muscle_degeneration0.99066951
99MP0002084_abnormal_developmental_patter0.98564218
100MP0002116_abnormal_craniofacial_bone0.96434136
101MP0002152_abnormal_brain_morphology0.96307611
102MP0002085_abnormal_embryonic_tissue0.96007104
103MP0005253_abnormal_eye_physiology0.95915619
104MP0002752_abnormal_somatic_nervous0.94553155
105MP0002009_preneoplasia0.94367327
106MP0002088_abnormal_embryonic_growth/wei0.93460038
107MP0004043_abnormal_pH_regulation0.93391919
108MP0002882_abnormal_neuron_morphology0.93192844
109MP0000377_abnormal_hair_follicle0.92352327
110MP0008770_decreased_survivor_rate0.92292182
111MP0003984_embryonic_growth_retardation0.91548874
112MP0000631_abnormal_neuroendocrine_gland0.91360163
113MP0002089_abnormal_postnatal_growth/wei0.90514648
114MP0004272_abnormal_basement_membrane0.90253875
115MP0009672_abnormal_birth_weight0.90045248
116MP0003941_abnormal_skin_development0.89354672
117MP0002234_abnormal_pharynx_morphology0.89115360
118MP0002272_abnormal_nervous_system0.89104690
119MP0003221_abnormal_cardiomyocyte_apopto0.88446609
120MP0002108_abnormal_muscle_morphology0.88023617
121* MP0002081_perinatal_lethality0.85186809
122MP0001177_atelectasis0.84869916
123MP0001440_abnormal_grooming_behavior0.84401523
124* MP0002733_abnormal_thermal_nociception0.84219607
125MP0005391_vision/eye_phenotype0.83839018
126MP0003136_yellow_coat_color0.83235274
127MP0003567_abnormal_fetal_cardiomyocyte0.83201117
128MP0003315_abnormal_perineum_morphology0.82822486
129MP0002092_abnormal_eye_morphology0.82487493
130MP0002896_abnormal_bone_mineralization0.80711305
131MP0004885_abnormal_endolymph0.80550422
132MP0004811_abnormal_neuron_physiology0.80299282
133MP0001188_hyperpigmentation0.79368871
134MP0004087_abnormal_muscle_fiber0.79025792
135MP0000462_abnormal_digestive_system0.78672864
136MP0000350_abnormal_cell_proliferation0.78294246
137MP0009053_abnormal_anal_canal0.77599749
138* MP0001970_abnormal_pain_threshold0.77491105
139MP0002067_abnormal_sensory_capabilities0.77464526
140MP0001501_abnormal_sleep_pattern0.76859995
141MP0004142_abnormal_muscle_tone0.76852301
142MP0002796_impaired_skin_barrier0.76791010
143MP0005423_abnormal_somatic_nervous0.76468238
144MP0002269_muscular_atrophy0.76035632
145MP0002877_abnormal_melanocyte_morpholog0.75665950
146MP0002249_abnormal_larynx_morphology0.75049487
147MP0004197_abnormal_fetal_growth/weight/0.74487292
148MP0009703_decreased_birth_body0.74220535
149MP0002160_abnormal_reproductive_system0.73385933
150MP0001697_abnormal_embryo_size0.72831941

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.02262156
2Hepatoblastoma (HP:0002884)4.58430706
3Abnormality of the lower motor neuron (HP:0002366)4.25478945
4Hypochromic microcytic anemia (HP:0004840)4.24560240
5Ependymoma (HP:0002888)3.93702037
6Rib fusion (HP:0000902)3.89742735
7Abnormality of the astrocytes (HP:0100707)3.42426521
8Astrocytoma (HP:0009592)3.42426521
9Amyotrophic lateral sclerosis (HP:0007354)3.02778905
10Nephroblastoma (Wilms tumor) (HP:0002667)3.00833940
11Horizontal nystagmus (HP:0000666)2.94505931
12Right ventricular cardiomyopathy (HP:0011663)2.93786896
13Hypoplasia of the fovea (HP:0007750)2.91911066
14Aplasia/Hypoplasia of the fovea (HP:0008060)2.91911066
15Heterotopia (HP:0002282)2.88956604
16Febrile seizures (HP:0002373)2.87686598
17Neoplasm of striated muscle (HP:0009728)2.85513975
18Embryonal renal neoplasm (HP:0011794)2.83148967
19Abnormality of the salivary glands (HP:0010286)2.78968650
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78203710
21Fused cervical vertebrae (HP:0002949)2.76796652
22Multiple enchondromatosis (HP:0005701)2.74453498
23Epileptic encephalopathy (HP:0200134)2.65753105
24Amblyopia (HP:0000646)2.60620252
25Testicular atrophy (HP:0000029)2.59247326
26Rhabdomyosarcoma (HP:0002859)2.52134366
27Short humerus (HP:0005792)2.51606079
28Rectal fistula (HP:0100590)2.49308582
29Rectovaginal fistula (HP:0000143)2.49308582
30Difficulty running (HP:0009046)2.46650297
31Aplasia/hypoplasia of the humerus (HP:0006507)2.43789933
32Glioma (HP:0009733)2.43041157
33Neoplasm of the heart (HP:0100544)2.42806484
34Generalized hypotonia (HP:0001290)2.40776711
35Pheochromocytoma (HP:0002666)2.39441009
36Hemiparesis (HP:0001269)2.38971353
37Bifid tongue (HP:0010297)2.37897572
38Curly hair (HP:0002212)2.36162274
39Dysmetric saccades (HP:0000641)2.35583458
40Papillary thyroid carcinoma (HP:0002895)2.32379810
41Hyperventilation (HP:0002883)2.32192385
42Intestinal fistula (HP:0100819)2.28631582
43Shawl scrotum (HP:0000049)2.27853067
44Genetic anticipation (HP:0003743)2.26334640
45Chromsome breakage (HP:0040012)2.25871906
46Abnormality of the fovea (HP:0000493)2.25430598
47Abnormality of chromosome segregation (HP:0002916)2.21384817
48Hyperinsulinemic hypoglycemia (HP:0000825)2.19452954
49Resting tremor (HP:0002322)2.18169958
50Large earlobe (HP:0009748)2.17562771
51Focal seizures (HP:0007359)2.14695608
52Preauricular pit (HP:0004467)2.14378184
53Periauricular skin pits (HP:0100277)2.14378184
54Partial duplication of thumb phalanx (HP:0009944)2.12177350
55Renal duplication (HP:0000075)2.11915648
56Malignant neoplasm of the central nervous system (HP:0100836)2.10381648
57Abnormality of the pubic bones (HP:0003172)2.09842163
58Abnormality of the corticospinal tract (HP:0002492)2.08283270
59Urinary bladder sphincter dysfunction (HP:0002839)2.06477719
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05146783
61Pendular nystagmus (HP:0012043)2.04475221
62Abnormality of the nasal septum (HP:0000419)2.03213568
63Supernumerary spleens (HP:0009799)2.00903703
64Abnormality of the musculature of the hand (HP:0001421)2.00690767
65Vertebral arch anomaly (HP:0008438)1.99047187
66Abnormality of the phalanges of the hallux (HP:0010057)1.97973356
67Midline defect of the nose (HP:0004122)1.93581534
68Mildly elevated creatine phosphokinase (HP:0008180)1.93266028
69Exercise-induced muscle cramps (HP:0003710)1.92887828
70Abnormality of the distal phalanx of the thumb (HP:0009617)1.92568186
71Progressive cerebellar ataxia (HP:0002073)1.92028655
72Deep philtrum (HP:0002002)1.91986982
73Achilles tendon contracture (HP:0001771)1.91223985
74Macroorchidism (HP:0000053)1.91196382
75Sensory axonal neuropathy (HP:0003390)1.91003883
76Partial duplication of the phalanx of hand (HP:0009999)1.90068892
77Neuroectodermal neoplasm (HP:0030061)1.89234176
78Neuroepithelial neoplasm (HP:0030063)1.89234176
79Nervous tissue neoplasm (HP:0030060)1.89234176
80Upper limb muscle weakness (HP:0003484)1.89198346
81Increased connective tissue (HP:0009025)1.88873418
82Vaginal fistula (HP:0004320)1.88847421
83Trismus (HP:0000211)1.88405028
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.88054758
85High anterior hairline (HP:0009890)1.87337176
86Dyschromatopsia (HP:0007641)1.84903328
87Hand muscle atrophy (HP:0009130)1.84107718
88Bronchomalacia (HP:0002780)1.83784266
89Abnormality of the ischium (HP:0003174)1.83002037
90Preauricular skin tag (HP:0000384)1.82871251
91Skin pits (HP:0100276)1.82599666
92Abnormality of the labia minora (HP:0012880)1.82161323
93Aplasia/Hypoplasia of the macula (HP:0008059)1.80966173
94Open mouth (HP:0000194)1.80016168
95Ragged-red muscle fibers (HP:0003200)1.78692159
96Absent eyebrow (HP:0002223)1.77744202
97Nasolacrimal duct obstruction (HP:0000579)1.77616352
98Arterial tortuosity (HP:0005116)1.75947160
99Abnormal lung lobation (HP:0002101)1.75886666
100Pseudobulbar signs (HP:0002200)1.75822743
101Supernumerary nipples (HP:0002558)1.74759944
102Truncal obesity (HP:0001956)1.74402494
103Vertebral fusion (HP:0002948)1.74364210
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74208041
105Hypoplastic labia majora (HP:0000059)1.73874337
106Gastroesophageal reflux (HP:0002020)1.73183478
107Leiomyosarcoma (HP:0100243)1.72510225
108Uterine leiomyosarcoma (HP:0002891)1.72510225
109Sparse lateral eyebrow (HP:0005338)1.71672817
110Morphological abnormality of the middle ear (HP:0008609)1.71436883
111Dialeptic seizures (HP:0011146)1.71410418
112Increased nuchal translucency (HP:0010880)1.69720594
113Flat acetabular roof (HP:0003180)1.69477569
114Volvulus (HP:0002580)1.68649193
115Germ cell neoplasia (HP:0100728)1.68505046
116Atonic seizures (HP:0010819)1.68201788
117Anomalous pulmonary venous return (HP:0010772)1.67787298
118Distal upper limb amyotrophy (HP:0007149)1.67428375
119Upper limb amyotrophy (HP:0009129)1.67428375
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66824235
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66298840
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.65792633
123Termporal pattern (HP:0011008)1.65728911
124Insidious onset (HP:0003587)1.65728911
125Webbed neck (HP:0000465)1.65607865
126Aplasia/Hypoplasia affecting the retina (HP:0008061)1.65525613
127Drooling (HP:0002307)1.65362841
128Excessive salivation (HP:0003781)1.65362841
129Abnormality of the labia majora (HP:0012881)1.64502621
130Skin tags (HP:0010609)1.63424589
131Absent frontal sinuses (HP:0002688)1.63404172
132Meckel diverticulum (HP:0002245)1.63386889
133Hyperkalemia (HP:0002153)1.63048315
134Deviation of the thumb (HP:0009603)1.62609022
135Abnormality of the calcaneus (HP:0008364)1.62465289
136Neuroendocrine neoplasm (HP:0100634)1.61805256
137Omphalocele (HP:0001539)1.61462797
138Subacute progressive viral hepatitis (HP:0006572)1.60690774
139Lip pit (HP:0100267)1.59103311
140Narrow palate (HP:0000189)1.58127122
141Hypoplastic ischia (HP:0003175)1.57269586
142Protruding tongue (HP:0010808)1.56780939
143Cystic hygroma (HP:0000476)1.56324608
144Cubitus valgus (HP:0002967)1.55634169
145Asymmetry of the thorax (HP:0001555)1.54950126
146Obsessive-compulsive behavior (HP:0000722)1.53994903
147Hyperacusis (HP:0010780)1.53940373
148Tented upper lip vermilion (HP:0010804)1.53871944
149Cutaneous finger syndactyly (HP:0010554)1.53520434
150Urinary urgency (HP:0000012)1.52699029
151Wide intermamillary distance (HP:0006610)1.51786504
152Overgrowth (HP:0001548)1.51629781
153Abnormality of nail color (HP:0100643)1.51558917
154Abnormality of the parathyroid morphology (HP:0011766)1.51407208
155Action tremor (HP:0002345)1.51342710
156Smooth philtrum (HP:0000319)1.51026173
157Bicornuate uterus (HP:0000813)1.50206394
158Transitional cell carcinoma of the bladder (HP:0006740)1.48866505
159Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.48828073
160Muscle fiber inclusion bodies (HP:0100299)1.47494943
161Tapered finger (HP:0001182)1.44447005
162Abnormality of the epiphyses of the hand (HP:0005924)1.44279993
163Exercise-induced myalgia (HP:0003738)1.43805684
164Nemaline bodies (HP:0003798)1.43449534
165Limited elbow extension (HP:0001377)1.42931252
166Broad nasal tip (HP:0000455)1.42681084
167Hypopigmentation of the fundus (HP:0007894)1.42633705
168Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.42323271
169Proximal placement of thumb (HP:0009623)1.42056060
170Hypoplasia of the iris (HP:0007676)1.41539671
171Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.40754112
172Vascular tortuosity (HP:0004948)1.40438879
173Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.40019547
174Exotropia (HP:0000577)1.39718891
175Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.39157456
176Abnormality of the aortic arch (HP:0012303)1.39060242
177Pulmonic stenosis (HP:0001642)1.38963413
178Advanced eruption of teeth (HP:0006288)1.37400316
179Infantile muscular hypotonia (HP:0008947)1.37300567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.58955139
2GRK54.76188785
3TYRO32.87759886
4MET2.74539992
5GRK62.62668587
6WNK12.51955132
7MST1R2.39669889
8LATS12.38239441
9MAP3K92.34776588
10ERN12.33708036
11ADRBK22.28201561
12BCR2.26500956
13GRK12.24780969
14NTRK12.16510123
15STK38L2.14732280
16GRK72.08659424
17STK392.07767891
18MATK2.01055775
19PKN21.98397861
20TTK1.98219712
21NTRK31.87188698
22MAPK71.78132108
23MARK11.74392180
24LATS21.68077279
25CAMK1G1.67511481
26MOS1.64354488
27TRIM281.64109280
28TRIB31.60012969
29MAP2K41.59339800
30CSF1R1.57988754
31MARK21.49934813
32CAMK41.48522018
33EPHA41.47614612
34ALK1.39942523
35PRKG21.37670280
36PAK61.37314767
37HIPK21.33335235
38TNIK1.33233542
39OBSCN1.32421615
40EPHA21.29419033
41EEF2K1.29134806
42STK381.22247427
43FGFR21.18954461
44ADRBK11.14682094
45OXSR11.14384186
46SGK31.13180743
47PIK3CA1.11903585
48TGFBR21.11876885
49WNK41.11593429
50RET1.11520514
51AKT31.10626304
52SGK21.09272224
53PRKD31.09200457
54NTRK21.09054828
55WEE11.08723951
56PRPF4B1.04704778
57FGFR11.04521025
58PDGFRB1.01080109
59FRK0.98619089
60MINK10.98266105
61SIK20.94071041
62FGFR40.92225737
63SGK2230.90332370
64SGK4940.90332370
65DDR20.89456583
66CHEK20.88734287
67CDK70.87768202
68SIK10.87593474
69EPHB10.85206387
70BRD40.83555526
71CAMK1D0.83503333
72FGFR30.81720577
73TRPM70.81652010
74CASK0.78544686
75MAP3K40.78204353
76PDGFRA0.74514589
77PAK30.74315983
78MAP3K70.74107857
79DMPK0.73848526
80MAP3K60.73205487
81UHMK10.70606631
82DYRK1A0.70181391
83MAP2K60.68583445
84FER0.66891584
85PTK20.66828563
86BMX0.66795308
87BRSK20.66401451
88NEK60.66148995
89PHKG10.65823788
90PHKG20.65823788
91SIK30.65759455
92STK100.65188214
93NEK90.64280578
94AKT20.63797636
95FGR0.63733479
96CDK150.63495741
97PAK40.63124214
98PLK10.61201008
99CDK180.60847183
100CDK140.60765804
101CSNK1E0.60122955
102MAPK100.59795793
103PRKD20.59695621
104CDK190.59017444
105STK30.58905396
106ICK0.58855592
107NEK20.58074293
108CDK11A0.56708563
109KSR20.56241441
110CDK50.56012497
111BRSK10.55951733
112PTK60.54596025
113PRKCG0.53903310
114RPS6KA40.53024818
115CHEK10.52891516
116EPHA30.52149223
117MELK0.52148928
118TSSK60.51904410
119MTOR0.50824379
120PRKAA20.50163198
121MKNK20.49962089
122TTN0.48862553
123MAP3K20.47470016
124RPS6KB10.46113928
125BMPR1B0.45460675
126NEK10.44695962
127DYRK20.44574913
128MAP3K130.44547998
129LMTK20.44407893
130ERBB20.44363741
131MKNK10.43854065
132GSK3B0.43776902
133CSK0.43709852
134CSNK1A1L0.43447441
135MAP2K10.42852489
136CDK20.42560536
137PRKCI0.42191656
138MAPK120.40877810
139ERBB30.39975831
140KSR10.39833290
141CDC42BPA0.38754484
142RPS6KA30.36961704
143CAMK10.36842131
144STK110.35101747
145MAPK140.34888671
146PLK20.34558733
147PNCK0.33913256
148EIF2AK20.33691064
149CDK10.30069043
150PRKAA10.28490397
151MAP2K70.26335442
152YES10.26127140
153MAPK130.26068607
154RIPK10.25218160
155MAPK80.24954664
156TAOK10.24363790
157DYRK1B0.24360118

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.13626655
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05042941
3Vitamin B6 metabolism_Homo sapiens_hsa007501.95416419
4Nicotine addiction_Homo sapiens_hsa050331.92304991
5Fructose and mannose metabolism_Homo sapiens_hsa000511.89695663
6Long-term potentiation_Homo sapiens_hsa047201.83576546
7Glutamatergic synapse_Homo sapiens_hsa047241.78617721
8Synaptic vesicle cycle_Homo sapiens_hsa047211.78163064
9GABAergic synapse_Homo sapiens_hsa047271.74523822
10Taste transduction_Homo sapiens_hsa047421.60657270
11mTOR signaling pathway_Homo sapiens_hsa041501.57882114
12Serotonergic synapse_Homo sapiens_hsa047261.52254127
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51748290
14Long-term depression_Homo sapiens_hsa047301.51079376
15Dopaminergic synapse_Homo sapiens_hsa047281.39428873
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37934107
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37275039
18GnRH signaling pathway_Homo sapiens_hsa049121.36568799
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36472018
20Circadian entrainment_Homo sapiens_hsa047131.33901608
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29118685
22Renal cell carcinoma_Homo sapiens_hsa052111.28972415
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28874479
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.28842632
25Salivary secretion_Homo sapiens_hsa049701.24580623
26Amphetamine addiction_Homo sapiens_hsa050311.23257248
27Hedgehog signaling pathway_Homo sapiens_hsa043401.23005398
28Olfactory transduction_Homo sapiens_hsa047401.22988449
29Fatty acid biosynthesis_Homo sapiens_hsa000611.22755937
30Lysine degradation_Homo sapiens_hsa003101.22360972
31Insulin signaling pathway_Homo sapiens_hsa049101.22328294
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20822710
33Phototransduction_Homo sapiens_hsa047441.20090803
34Oxytocin signaling pathway_Homo sapiens_hsa049211.17326974
35Inositol phosphate metabolism_Homo sapiens_hsa005621.16490485
36Axon guidance_Homo sapiens_hsa043601.15962964
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15399006
38Morphine addiction_Homo sapiens_hsa050321.14229096
39Galactose metabolism_Homo sapiens_hsa000521.14083601
40Choline metabolism in cancer_Homo sapiens_hsa052311.13438540
41Wnt signaling pathway_Homo sapiens_hsa043101.13396771
42Insulin secretion_Homo sapiens_hsa049111.12411256
43Circadian rhythm_Homo sapiens_hsa047101.12273911
44Glucagon signaling pathway_Homo sapiens_hsa049221.11522914
45Calcium signaling pathway_Homo sapiens_hsa040201.11118131
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10981900
47Renin secretion_Homo sapiens_hsa049241.09765168
48Thyroid cancer_Homo sapiens_hsa052161.09341884
49Arachidonic acid metabolism_Homo sapiens_hsa005901.09021742
50Basal cell carcinoma_Homo sapiens_hsa052171.06123550
51Hippo signaling pathway_Homo sapiens_hsa043901.05884193
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05492063
53ErbB signaling pathway_Homo sapiens_hsa040121.05140698
54Cholinergic synapse_Homo sapiens_hsa047251.02730618
55Dilated cardiomyopathy_Homo sapiens_hsa054141.01851933
56Prostate cancer_Homo sapiens_hsa052151.01666134
57Gap junction_Homo sapiens_hsa045401.00689871
58Steroid biosynthesis_Homo sapiens_hsa001000.99864307
59Focal adhesion_Homo sapiens_hsa045100.99514412
60ECM-receptor interaction_Homo sapiens_hsa045120.99411451
61cAMP signaling pathway_Homo sapiens_hsa040240.98439732
62Melanogenesis_Homo sapiens_hsa049160.98417305
63Prolactin signaling pathway_Homo sapiens_hsa049170.98357791
64Thyroid hormone synthesis_Homo sapiens_hsa049180.97849839
65Chronic myeloid leukemia_Homo sapiens_hsa052200.97848489
66Rap1 signaling pathway_Homo sapiens_hsa040150.97493944
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96971381
68mRNA surveillance pathway_Homo sapiens_hsa030150.96706084
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95908321
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95899359
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95861990
72Gastric acid secretion_Homo sapiens_hsa049710.94711433
73Small cell lung cancer_Homo sapiens_hsa052220.94430394
74Tight junction_Homo sapiens_hsa045300.90958587
75Dorso-ventral axis formation_Homo sapiens_hsa043200.90926975
76VEGF signaling pathway_Homo sapiens_hsa043700.90786943
77Cocaine addiction_Homo sapiens_hsa050300.89721580
78ABC transporters_Homo sapiens_hsa020100.88577146
79Pancreatic cancer_Homo sapiens_hsa052120.87670699
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.86278357
81Glioma_Homo sapiens_hsa052140.85551068
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84381440
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84337903
84Ovarian steroidogenesis_Homo sapiens_hsa049130.84313880
85Notch signaling pathway_Homo sapiens_hsa043300.82752201
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.82525489
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82278760
88Fatty acid metabolism_Homo sapiens_hsa012120.82021075
89Oocyte meiosis_Homo sapiens_hsa041140.80918588
90FoxO signaling pathway_Homo sapiens_hsa040680.80807462
91MicroRNAs in cancer_Homo sapiens_hsa052060.79356650
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78917962
93Estrogen signaling pathway_Homo sapiens_hsa049150.78605566
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78197507
95Endometrial cancer_Homo sapiens_hsa052130.76984426
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76796656
97Non-homologous end-joining_Homo sapiens_hsa034500.76427910
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.75199424
99Proteoglycans in cancer_Homo sapiens_hsa052050.75169493
100Ras signaling pathway_Homo sapiens_hsa040140.74556472
101Linoleic acid metabolism_Homo sapiens_hsa005910.74166729
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.73213874
103MAPK signaling pathway_Homo sapiens_hsa040100.72952176
104Cardiac muscle contraction_Homo sapiens_hsa042600.72785429
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72581989
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71829589
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71453066
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71423631
109Insulin resistance_Homo sapiens_hsa049310.70969375
110Pathways in cancer_Homo sapiens_hsa052000.70748842
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70388111
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70300218
113Bladder cancer_Homo sapiens_hsa052190.70218040
114TGF-beta signaling pathway_Homo sapiens_hsa043500.69251950
115Type II diabetes mellitus_Homo sapiens_hsa049300.68593822
116Non-small cell lung cancer_Homo sapiens_hsa052230.67673039
117Colorectal cancer_Homo sapiens_hsa052100.66988394
118Adherens junction_Homo sapiens_hsa045200.66955457
119Cell cycle_Homo sapiens_hsa041100.65905484
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65124675
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63968717
122Arginine and proline metabolism_Homo sapiens_hsa003300.61562303
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58304911
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57764577
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55273610
126AMPK signaling pathway_Homo sapiens_hsa041520.54935619
127Collecting duct acid secretion_Homo sapiens_hsa049660.51243616
128Melanoma_Homo sapiens_hsa052180.50708090
129Acute myeloid leukemia_Homo sapiens_hsa052210.50667603
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49978062
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48317861

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