NPFFR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.75580027
2neuron cell-cell adhesion (GO:0007158)5.42897389
3fucose catabolic process (GO:0019317)4.87733487
4L-fucose metabolic process (GO:0042354)4.87733487
5L-fucose catabolic process (GO:0042355)4.87733487
6tryptophan catabolic process (GO:0006569)4.71528743
7indole-containing compound catabolic process (GO:0042436)4.71528743
8indolalkylamine catabolic process (GO:0046218)4.71528743
9axon ensheathment in central nervous system (GO:0032291)4.69833170
10central nervous system myelination (GO:0022010)4.69833170
11kynurenine metabolic process (GO:0070189)4.62595794
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51738805
13presynaptic membrane assembly (GO:0097105)4.36554049
14ATP synthesis coupled proton transport (GO:0015986)4.34261110
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34261110
16neuron recognition (GO:0008038)4.27976019
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17081607
18dopamine biosynthetic process (GO:0042416)4.15994236
19indolalkylamine metabolic process (GO:0006586)4.15394376
20presynaptic membrane organization (GO:0097090)4.08395290
21vocalization behavior (GO:0071625)4.02371444
22tryptophan metabolic process (GO:0006568)3.99412635
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.97160295
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.93609811
25glutamate receptor signaling pathway (GO:0007215)3.90814446
26neuron remodeling (GO:0016322)3.90153474
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.84687045
28response to pheromone (GO:0019236)3.78434286
29positive regulation of synapse assembly (GO:0051965)3.77479490
30protein localization to synapse (GO:0035418)3.73961968
31transmission of nerve impulse (GO:0019226)3.73251280
32negative regulation of neurotransmitter transport (GO:0051589)3.71831347
33neuronal action potential propagation (GO:0019227)3.69783263
34cellular ketone body metabolic process (GO:0046950)3.61179115
35long-chain fatty acid biosynthetic process (GO:0042759)3.59004440
36platelet dense granule organization (GO:0060155)3.58161837
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.54339418
38axonal fasciculation (GO:0007413)3.51941799
39regulation of glutamate secretion (GO:0014048)3.50925861
40DNA deamination (GO:0045006)3.48063523
41regulation of catecholamine metabolic process (GO:0042069)3.47228783
42regulation of dopamine metabolic process (GO:0042053)3.47228783
43dendritic spine morphogenesis (GO:0060997)3.46576955
44sulfation (GO:0051923)3.45602591
45negative regulation of mast cell activation (GO:0033004)3.43806317
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40471826
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.40471826
48NADH dehydrogenase complex assembly (GO:0010257)3.40471826
49regulation of memory T cell differentiation (GO:0043380)3.40372795
50mating behavior (GO:0007617)3.40175144
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39953916
52water-soluble vitamin biosynthetic process (GO:0042364)3.35582006
53indole-containing compound metabolic process (GO:0042430)3.33528536
54respiratory electron transport chain (GO:0022904)3.30649833
55detection of light stimulus involved in sensory perception (GO:0050962)3.26939897
56detection of light stimulus involved in visual perception (GO:0050908)3.26939897
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26125913
58electron transport chain (GO:0022900)3.24668281
59ketone body metabolic process (GO:1902224)3.24163279
60protein complex biogenesis (GO:0070271)3.23351410
61gamma-aminobutyric acid transport (GO:0015812)3.22529520
62limb bud formation (GO:0060174)3.19871346
63dopamine transport (GO:0015872)3.18420667
64neuron-neuron synaptic transmission (GO:0007270)3.17314401
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16546828
66neural tube formation (GO:0001841)3.15525655
67fatty acid elongation (GO:0030497)3.14523743
68synaptic transmission, dopaminergic (GO:0001963)3.13641847
69short-term memory (GO:0007614)3.13410772
70behavioral response to ethanol (GO:0048149)3.10035073
71negative regulation of multicellular organism growth (GO:0040015)3.10013184
72postsynaptic membrane organization (GO:0001941)3.08490194
73mitochondrial respiratory chain complex assembly (GO:0033108)3.08360193
74positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.07483184
75cellular biogenic amine catabolic process (GO:0042402)3.07261160
76amine catabolic process (GO:0009310)3.07261160
77negative regulation of telomere maintenance (GO:0032205)3.05677793
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.05123721
79neurotransmitter catabolic process (GO:0042135)3.04519077
80response to histamine (GO:0034776)3.04423598
81regulation of action potential (GO:0098900)3.01711637
82behavioral response to cocaine (GO:0048148)3.00957817
83regulation of vesicle fusion (GO:0031338)3.00486425
84righting reflex (GO:0060013)3.00176555
85primary amino compound metabolic process (GO:1901160)2.99438482
86keratinocyte development (GO:0003334)2.99348627
87reflex (GO:0060004)2.98383932
88synaptic vesicle exocytosis (GO:0016079)2.98153601
89positive regulation of dendritic spine development (GO:0060999)2.94786533
90synaptic transmission, cholinergic (GO:0007271)2.94248622
91startle response (GO:0001964)2.93809341
92phenol-containing compound catabolic process (GO:0019336)2.93522643
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93056736
94negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.91997813
95regulation of glutamate receptor signaling pathway (GO:1900449)2.91876688
96NAD biosynthetic process (GO:0009435)2.91602298
97regulation of synapse assembly (GO:0051963)2.90673174
98catechol-containing compound biosynthetic process (GO:0009713)2.89965752
99catecholamine biosynthetic process (GO:0042423)2.89965752
100neuronal action potential (GO:0019228)2.89823836
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89222410
102protein K11-linked deubiquitination (GO:0035871)2.89215524
103piRNA metabolic process (GO:0034587)2.87762106
104kidney morphogenesis (GO:0060993)2.85766534
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85296767
106synaptic transmission, glutamatergic (GO:0035249)2.84177306
107serotonin metabolic process (GO:0042428)2.82715139
108cellular response to epinephrine stimulus (GO:0071872)2.82268569
109calcium-mediated signaling using intracellular calcium source (GO:0035584)2.82264370
110regulation of dendritic spine development (GO:0060998)2.81845499
111regulation of postsynaptic membrane potential (GO:0060078)2.81503891
112regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81365290
113regulation of dendritic spine morphogenesis (GO:0061001)2.81147015
114preassembly of GPI anchor in ER membrane (GO:0016254)2.80299215
115regulation of hippo signaling (GO:0035330)2.79672627
116cerebral cortex radially oriented cell migration (GO:0021799)2.78734610
117protein-cofactor linkage (GO:0018065)2.77481812
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76791693
119maternal behavior (GO:0042711)2.75802701
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74169013
121substantia nigra development (GO:0021762)2.73477093
122aromatic amino acid family catabolic process (GO:0009074)2.70637509
123response to epinephrine (GO:0071871)2.70507203
124myelination (GO:0042552)2.70434303
125protein polyglutamylation (GO:0018095)2.69443783
126chaperone-mediated protein transport (GO:0072321)2.68328125
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68181401
128detection of calcium ion (GO:0005513)2.67951130
129axoneme assembly (GO:0035082)2.67148684
130negative regulation of protein localization to cell surface (GO:2000009)2.66889511
131response to cocaine (GO:0042220)2.66404885
132sex differentiation (GO:0007548)2.66287103
133retinal cone cell development (GO:0046549)2.65260387
134axon ensheathment (GO:0008366)2.65177264
135ensheathment of neurons (GO:0007272)2.65177264
136respiratory chain complex IV assembly (GO:0008535)2.65116637
137auditory receptor cell stereocilium organization (GO:0060088)2.65096145
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64925988
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.64310662
140negative regulation of reactive oxygen species metabolic process (GO:2000378)2.63996002
141nonmotile primary cilium assembly (GO:0035058)2.63738965
142synapse assembly (GO:0007416)2.63502878
143GTP biosynthetic process (GO:0006183)2.62307668
144proline transport (GO:0015824)2.62077091
145cellular response to ATP (GO:0071318)2.61882009
146adaptation of signaling pathway (GO:0023058)2.60989798
147cAMP catabolic process (GO:0006198)2.60832466
148retina layer formation (GO:0010842)2.60029448
149positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59890384
150regulation of posttranscriptional gene silencing (GO:0060147)2.59620066
151regulation of gene silencing by miRNA (GO:0060964)2.59620066
152regulation of gene silencing by RNA (GO:0060966)2.59620066
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59510061
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58125814
155cornea development in camera-type eye (GO:0061303)2.57577119
156dendrite development (GO:0016358)2.56998955
157multicellular organism reproduction (GO:0032504)2.56432907
158regulation of protein kinase A signaling (GO:0010738)2.55942081
159protein localization to cilium (GO:0061512)2.55941471
160parturition (GO:0007567)2.55664271
161regulation of feeding behavior (GO:0060259)2.55378494
162regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54092433
163photoreceptor cell development (GO:0042461)2.52993909
164positive regulation of response to oxidative stress (GO:1902884)2.52799527
165positive regulation of cellular response to oxidative stress (GO:1900409)2.52799527
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52710655
167fear response (GO:0042596)2.52640463
168cilium movement (GO:0003341)2.52174190
169histone H2B ubiquitination (GO:0033523)2.51982695
170rhodopsin mediated signaling pathway (GO:0016056)2.51122113
171benzene-containing compound metabolic process (GO:0042537)2.50913894
172epithelial cilium movement (GO:0003351)2.50647805
173positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.50636091
174negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49602911
175regulation of respiratory system process (GO:0044065)2.48644458
176long-term synaptic potentiation (GO:0060291)2.48541072
177layer formation in cerebral cortex (GO:0021819)2.48349957
178phosphatidylinositol acyl-chain remodeling (GO:0036149)2.47938973
179oxidative demethylation (GO:0070989)2.47011858
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46774076
181negative regulation of translation, ncRNA-mediated (GO:0040033)2.46774076
182regulation of translation, ncRNA-mediated (GO:0045974)2.46774076
183photoreceptor cell maintenance (GO:0045494)2.43809436
184signal peptide processing (GO:0006465)2.43194841
185cilium morphogenesis (GO:0060271)2.42211178
186detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42128898
187fucosylation (GO:0036065)2.41239409
188regulation of nuclear cell cycle DNA replication (GO:0033262)2.40511407
189regulation of mesoderm development (GO:2000380)2.39832559
190regulation of establishment of cell polarity (GO:2000114)2.39825581
191alanine transport (GO:0032328)2.39596731
192positive regulation of fatty acid oxidation (GO:0046321)2.39142298
193rRNA catabolic process (GO:0016075)2.38788369
194spinal cord motor neuron differentiation (GO:0021522)2.37837274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02767437
2GBX2_23144817_ChIP-Seq_PC3_Human3.59449401
3TAF15_26573619_Chip-Seq_HEK293_Human3.12002862
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04436028
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87065860
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81246123
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.66286968
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.54078793
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53021474
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49817837
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48271014
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44997273
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41649291
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41649291
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38526811
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33772181
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.31042707
18VDR_22108803_ChIP-Seq_LS180_Human2.30700252
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23497359
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.20937538
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18158492
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11613326
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01330151
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00355057
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98025523
26FUS_26573619_Chip-Seq_HEK293_Human1.95333781
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.94995585
28AR_21572438_ChIP-Seq_LNCaP_Human1.94093428
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93424547
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.89665798
31* P300_19829295_ChIP-Seq_ESCs_Human1.89272655
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.88906754
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84099331
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80866886
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79374517
36REST_21632747_ChIP-Seq_MESCs_Mouse1.76946610
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74283581
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74192078
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69059493
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68084970
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.66536816
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.65616377
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63490942
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62550442
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62041756
46RNF2_27304074_Chip-Seq_NSC_Mouse1.61532503
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61019544
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60827425
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60380371
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60267469
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59427809
52SMAD4_21799915_ChIP-Seq_A2780_Human1.59418079
53IGF1R_20145208_ChIP-Seq_DFB_Human1.54522342
54TP53_22573176_ChIP-Seq_HFKS_Human1.52647731
55IRF1_19129219_ChIP-ChIP_H3396_Human1.52410825
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.51151538
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51080058
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50000585
59ER_23166858_ChIP-Seq_MCF-7_Human1.49456737
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45741834
61ZNF274_21170338_ChIP-Seq_K562_Hela1.43617966
62CBP_20019798_ChIP-Seq_JUKART_Human1.42095980
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42095980
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39855090
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39388277
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38057104
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.38057104
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36868495
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35601890
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.33184478
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32119681
72MYC_18940864_ChIP-ChIP_HL60_Human1.30963064
73TCF4_22108803_ChIP-Seq_LS180_Human1.30445984
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29569141
75TP53_18474530_ChIP-ChIP_U2OS_Human1.27766424
76* SOX2_19829295_ChIP-Seq_ESCs_Human1.27553116
77* NANOG_19829295_ChIP-Seq_ESCs_Human1.27553116
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26077370
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25843957
80DROSHA_22980978_ChIP-Seq_HELA_Human1.25727898
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25202066
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23541865
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.23492433
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.23470565
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23110136
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22934700
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.22505421
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.22358555
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.21027485
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21024486
91EWS_26573619_Chip-Seq_HEK293_Human1.20773312
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20159624
93NCOR_22424771_ChIP-Seq_293T_Human1.19590485
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18257820
95AR_25329375_ChIP-Seq_VCAP_Human1.17777018
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.17659201
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.17217545
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15807154
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15704499
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15140718
101BCAT_22108803_ChIP-Seq_LS180_Human1.13742220
102AR_20517297_ChIP-Seq_VCAP_Human1.13358607
103GABP_17652178_ChIP-ChIP_JURKAT_Human1.13068451
104TP53_16413492_ChIP-PET_HCT116_Human1.13063032
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.12188945
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.11705451
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.10306913
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.10133862
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08413273
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08413273
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08214668
112* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08119489
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.07627277
114* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07490949
115P53_22387025_ChIP-Seq_ESCs_Mouse1.06770012
116STAT3_23295773_ChIP-Seq_U87_Human1.06458387
117KDM2B_26808549_Chip-Seq_REH_Human1.06065108
118POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05947567
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05150173
120JUN_21703547_ChIP-Seq_K562_Human1.04793198
121HOXB7_26014856_ChIP-Seq_BT474_Human1.04356121
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03292582
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02905569
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02871257
125* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02689716
126CDX2_22108803_ChIP-Seq_LS180_Human1.02546309
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01801619
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01415119
129TCF4_23295773_ChIP-Seq_U87_Human1.01299995
130P300_18555785_Chip-Seq_ESCs_Mouse1.01181370
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.00667033
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00337536
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00219163
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00207113
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.99657437
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.99432134
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.98506938
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.97128436
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97057036
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93735302
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92546429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.64196506
2MP0003635_abnormal_synaptic_transmissio2.94721849
3MP0004859_abnormal_synaptic_plasticity2.94270662
4MP0003195_calcinosis2.89595016
5MP0009745_abnormal_behavioral_response2.86887349
6MP0004270_analgesia2.79818005
7MP0001529_abnormal_vocalization2.76059367
8MP0006276_abnormal_autonomic_nervous2.75516255
9MP0009379_abnormal_foot_pigmentation2.64288099
10MP0002064_seizures2.60550529
11MP0000569_abnormal_digit_pigmentation2.59982680
12MP0001905_abnormal_dopamine_level2.55867240
13MP0001440_abnormal_grooming_behavior2.51628003
14MP0003136_yellow_coat_color2.51129269
15MP0001968_abnormal_touch/_nociception2.50155287
16MP0009046_muscle_twitch2.47695869
17MP0001486_abnormal_startle_reflex2.45526169
18MP0002272_abnormal_nervous_system2.43585458
19MP0005423_abnormal_somatic_nervous2.43287156
20MP0005409_darkened_coat_color2.42765073
21MP0002572_abnormal_emotion/affect_behav2.40635796
22MP0008877_abnormal_DNA_methylation2.31738939
23MP0001501_abnormal_sleep_pattern2.31017226
24MP0002063_abnormal_learning/memory/cond2.30174700
25MP0001188_hyperpigmentation2.28423769
26MP0003011_delayed_dark_adaptation2.21098430
27MP0000778_abnormal_nervous_system2.13104354
28MP0003646_muscle_fatigue2.12576923
29MP0002734_abnormal_mechanical_nocicepti2.10892760
30MP0001986_abnormal_taste_sensitivity2.06811677
31MP0002736_abnormal_nociception_after2.05898020
32MP0008875_abnormal_xenobiotic_pharmacok2.00127428
33MP0004742_abnormal_vestibular_system1.95435602
34MP0002735_abnormal_chemical_nociception1.91483916
35MP0004043_abnormal_pH_regulation1.88205490
36MP0002067_abnormal_sensory_capabilities1.86234633
37MP0002822_catalepsy1.82327691
38MP0002653_abnormal_ependyma_morphology1.74925568
39MP0002184_abnormal_innervation1.73103029
40MP0002733_abnormal_thermal_nociception1.72927053
41MP0000427_abnormal_hair_cycle1.72905538
42MP0002102_abnormal_ear_morphology1.72236026
43MP0002938_white_spotting1.71079305
44MP0001970_abnormal_pain_threshold1.70200574
45MP0004142_abnormal_muscle_tone1.69364865
46MP0004147_increased_porphyrin_level1.68396271
47MP0005174_abnormal_tail_pigmentation1.64663974
48MP0003329_amyloid_beta_deposits1.57379700
49MP0000920_abnormal_myelination1.55793679
50MP0002837_dystrophic_cardiac_calcinosis1.52824097
51MP0004133_heterotaxia1.52269814
52MP0002557_abnormal_social/conspecific_i1.51469444
53MP0005386_behavior/neurological_phenoty1.47877628
54MP0004924_abnormal_behavior1.47877628
55MP0000372_irregular_coat_pigmentation1.45737065
56MP0003252_abnormal_bile_duct1.44604942
57MP0004381_abnormal_hair_follicle1.44074126
58MP0005551_abnormal_eye_electrophysiolog1.41556115
59MP0005171_absent_coat_pigmentation1.36914295
60MP0005084_abnormal_gallbladder_morpholo1.36089431
61MP0005379_endocrine/exocrine_gland_phen1.35657335
62MP0006072_abnormal_retinal_apoptosis1.34519696
63MP0001984_abnormal_olfaction1.31352702
64MP0003787_abnormal_imprinting1.30590036
65MP0005645_abnormal_hypothalamus_physiol1.27586629
66MP0002138_abnormal_hepatobiliary_system1.26772447
67MP0003938_abnormal_ear_development1.26273414
68MP0002882_abnormal_neuron_morphology1.26266887
69MP0002066_abnormal_motor_capabilities/c1.20082727
70MP0000026_abnormal_inner_ear1.19492254
71MP0002160_abnormal_reproductive_system1.19378554
72MP0001963_abnormal_hearing_physiology1.19121867
73MP0000955_abnormal_spinal_cord1.18959740
74MP0010386_abnormal_urinary_bladder1.16639269
75MP0004145_abnormal_muscle_electrophysio1.15823803
76MP0002752_abnormal_somatic_nervous1.15309621
77MP0005389_reproductive_system_phenotype1.13265250
78MP0000383_abnormal_hair_follicle1.12770768
79MP0001485_abnormal_pinna_reflex1.11807921
80MP0003283_abnormal_digestive_organ1.11410915
81MP0002638_abnormal_pupillary_reflex1.09854344
82MP0002234_abnormal_pharynx_morphology1.09405857
83MP0003122_maternal_imprinting1.09115867
84MP0006292_abnormal_olfactory_placode1.08556413
85MP0000631_abnormal_neuroendocrine_gland1.08416149
86MP0004885_abnormal_endolymph1.06334134
87MP0002928_abnormal_bile_duct1.05986487
88MP0004130_abnormal_muscle_cell1.05535254
89MP0003718_maternal_effect1.04942622
90MP0001502_abnormal_circadian_rhythm1.00637868
91MP0005623_abnormal_meninges_morphology1.00447879
92MP0002095_abnormal_skin_pigmentation0.98538551
93MP0002229_neurodegeneration0.96888121
94MP0008569_lethality_at_weaning0.96352134
95MP0002277_abnormal_respiratory_mucosa0.95527642
96MP0003634_abnormal_glial_cell0.95003707
97MP0002152_abnormal_brain_morphology0.94427792
98MP0003137_abnormal_impulse_conducting0.93604421
99MP0000230_abnormal_systemic_arterial0.93392436
100MP0002163_abnormal_gland_morphology0.92161561
101MP0005646_abnormal_pituitary_gland0.89959185
102MP0005075_abnormal_melanosome_morpholog0.89540776
103MP0003878_abnormal_ear_physiology0.88500560
104MP0005377_hearing/vestibular/ear_phenot0.88500560
105MP0001919_abnormal_reproductive_system0.88183525
106MP0002693_abnormal_pancreas_physiology0.86063574
107MP0004215_abnormal_myocardial_fiber0.85476962
108MP0001664_abnormal_digestion0.84141609
109MP0001324_abnormal_eye_pigmentation0.82457118
110MP0003119_abnormal_digestive_system0.80661078
111MP0005410_abnormal_fertilization0.79854321
112MP0005085_abnormal_gallbladder_physiolo0.79433360
113MP0000462_abnormal_digestive_system0.79263414
114MP0001727_abnormal_embryo_implantation0.78523064
115MP0003631_nervous_system_phenotype0.78412682
116MP0002876_abnormal_thyroid_physiology0.78052987
117MP0003632_abnormal_nervous_system0.77718272
118MP0003690_abnormal_glial_cell0.77000384
119MP0005332_abnormal_amino_acid0.75455971
120MP0003698_abnormal_male_reproductive0.75213203
121MP0005253_abnormal_eye_physiology0.74503505
122MP0002751_abnormal_autonomic_nervous0.74336526
123MP0003937_abnormal_limbs/digits/tail_de0.74105473
124MP0004085_abnormal_heartbeat0.74083797
125MP0000647_abnormal_sebaceous_gland0.73700188
126MP0000762_abnormal_tongue_morphology0.73059380
127MP0005195_abnormal_posterior_eye0.72288627
128MP0000049_abnormal_middle_ear0.71873586
129MP0008872_abnormal_physiological_respon0.71806862
130MP0005167_abnormal_blood-brain_barrier0.71766234
131MP0003633_abnormal_nervous_system0.69940203
132MP0004484_altered_response_of0.68285675
133MP0003879_abnormal_hair_cell0.67669269
134MP0005535_abnormal_body_temperature0.67405854
135MP0002069_abnormal_eating/drinking_beha0.66356114
136MP0004811_abnormal_neuron_physiology0.65806865
137MP0002090_abnormal_vision0.65781945
138MP0000538_abnormal_urinary_bladder0.65173159
139MP0005394_taste/olfaction_phenotype0.64767862
140MP0005499_abnormal_olfactory_system0.64767862
141MP0009250_abnormal_appendicular_skeleto0.63145116
142MP0001340_abnormal_eyelid_morphology0.61214949
143MP0008874_decreased_physiological_sensi0.59853728
144MP0001943_abnormal_respiration0.59835742
145MP0003861_abnormal_nervous_system0.59108454

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.25009139
2Pancreatic cysts (HP:0001737)4.69596859
3Congenital stationary night blindness (HP:0007642)4.18817675
4Abnormal ciliary motility (HP:0012262)4.05415934
5Pancreatic fibrosis (HP:0100732)4.00355002
6Molar tooth sign on MRI (HP:0002419)3.99739013
7Abnormality of midbrain morphology (HP:0002418)3.99739013
8Neurofibrillary tangles (HP:0002185)3.95737065
9True hermaphroditism (HP:0010459)3.94468293
10Cerebral inclusion bodies (HP:0100314)3.82782482
11Atonic seizures (HP:0010819)3.78703329
12Parakeratosis (HP:0001036)3.72266090
13Pendular nystagmus (HP:0012043)3.70431897
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.67118936
15Absent/shortened dynein arms (HP:0200106)3.67118936
16Acute necrotizing encephalopathy (HP:0006965)3.66840828
17Genetic anticipation (HP:0003743)3.63235035
18Focal seizures (HP:0007359)3.57186336
19Nephronophthisis (HP:0000090)3.52868293
20Abnormal respiratory motile cilium physiology (HP:0012261)3.50374403
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.38643437
22Attenuation of retinal blood vessels (HP:0007843)3.38426551
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38011324
24Abnormal respiratory motile cilium morphology (HP:0005938)3.33959559
25Abnormal respiratory epithelium morphology (HP:0012253)3.33959559
26Abnormality of the renal cortex (HP:0011035)3.33562103
27Hyperventilation (HP:0002883)3.30310515
28Progressive macrocephaly (HP:0004481)3.26821901
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20657788
30Abnormality of alanine metabolism (HP:0010916)3.20657788
31Hyperalaninemia (HP:0003348)3.20657788
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.13575330
33Degeneration of the lateral corticospinal tracts (HP:0002314)3.13575330
34Type II lissencephaly (HP:0007260)3.09954001
35Abnormality of the renal medulla (HP:0100957)3.08525896
36Increased hepatocellular lipid droplets (HP:0006565)3.06514014
37Gaze-evoked nystagmus (HP:0000640)3.01453656
38Epileptic encephalopathy (HP:0200134)3.00129627
39Abolished electroretinogram (ERG) (HP:0000550)2.99171561
40Mitochondrial inheritance (HP:0001427)2.97300520
41Absence seizures (HP:0002121)2.92598732
42Abnormal mitochondria in muscle tissue (HP:0008316)2.90708285
43Dialeptic seizures (HP:0011146)2.89888482
44Renal Fanconi syndrome (HP:0001994)2.88837153
45Limb dystonia (HP:0002451)2.83448337
46Visual hallucinations (HP:0002367)2.82711816
47Retinal dysplasia (HP:0007973)2.82466903
48Keratoconus (HP:0000563)2.81356000
49Increased corneal curvature (HP:0100692)2.81356000
50Broad-based gait (HP:0002136)2.78531387
51Acute encephalopathy (HP:0006846)2.76111882
52Cystic liver disease (HP:0006706)2.73036995
53Chronic hepatic failure (HP:0100626)2.71982246
54Optic disc pallor (HP:0000543)2.67387842
55Congenital, generalized hypertrichosis (HP:0004540)2.67359933
56Tubular atrophy (HP:0000092)2.67096866
57Febrile seizures (HP:0002373)2.66492976
58Amblyopia (HP:0000646)2.64836300
59Sensory axonal neuropathy (HP:0003390)2.62769659
60Myokymia (HP:0002411)2.61838355
61Abnormality of the axillary hair (HP:0100134)2.61286042
62Abnormality of secondary sexual hair (HP:0009888)2.61286042
63Decreased central vision (HP:0007663)2.59529990
64Large for gestational age (HP:0001520)2.58769477
65Peripheral hypomyelination (HP:0007182)2.57658716
66Progressive cerebellar ataxia (HP:0002073)2.56035853
67Generalized tonic-clonic seizures (HP:0002069)2.54891054
68Furrowed tongue (HP:0000221)2.54087301
69Renal cortical cysts (HP:0000803)2.53881443
70Sclerocornea (HP:0000647)2.48177044
71Abnormal rod and cone electroretinograms (HP:0008323)2.46371871
72Chorioretinal atrophy (HP:0000533)2.44208969
73Lipid accumulation in hepatocytes (HP:0006561)2.42387069
74Hypothermia (HP:0002045)2.42365202
75Progressive inability to walk (HP:0002505)2.41014667
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39639474
77Abnormality of the corticospinal tract (HP:0002492)2.36742339
78Abnormal drinking behavior (HP:0030082)2.36139519
79Polydipsia (HP:0001959)2.36139519
80Hemiparesis (HP:0001269)2.34712752
81Congenital sensorineural hearing impairment (HP:0008527)2.33753645
82Thickened helices (HP:0000391)2.23619081
83Excessive salivation (HP:0003781)2.23368243
84Drooling (HP:0002307)2.23368243
85Supranuclear gaze palsy (HP:0000605)2.21252194
86Genital tract atresia (HP:0001827)2.19293343
87Rhinitis (HP:0012384)2.17755270
88Absent speech (HP:0001344)2.17697406
89Bile duct proliferation (HP:0001408)2.16827496
90Abnormal biliary tract physiology (HP:0012439)2.16827496
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16601050
92Gait imbalance (HP:0002141)2.16149058
93Concave nail (HP:0001598)2.15744033
94Vaginal atresia (HP:0000148)2.14577368
95Increased CSF lactate (HP:0002490)2.13387875
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13229099
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12814659
98Abnormality of binocular vision (HP:0011514)2.12056610
99Diplopia (HP:0000651)2.12056610
100Congenital ichthyosiform erythroderma (HP:0007431)2.12015633
101Medial flaring of the eyebrow (HP:0010747)2.11699893
102Lissencephaly (HP:0001339)2.11426227
103Cupped ear (HP:0000378)2.10871832
104Dysmetria (HP:0001310)2.10735004
105Abnormality of macular pigmentation (HP:0008002)2.10160902
106Esotropia (HP:0000565)2.06992632
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06744027
108Anencephaly (HP:0002323)2.06678202
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.06493649
110Leukodystrophy (HP:0002415)2.04997880
111Abnormality of the pons (HP:0007361)2.04033366
112Protruding tongue (HP:0010808)2.04023091
113Inability to walk (HP:0002540)2.03887638
114Male pseudohermaphroditism (HP:0000037)2.03161198
115Stomach cancer (HP:0012126)2.02155851
116Termporal pattern (HP:0011008)1.99742154
117Insidious onset (HP:0003587)1.99742154
118Abnormality of the parathyroid morphology (HP:0011766)1.99460034
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.99102673
120Exotropia (HP:0000577)1.99083229
121Congenital hepatic fibrosis (HP:0002612)1.98956191
122Abnormality of renal resorption (HP:0011038)1.98254736
123Birth length less than 3rd percentile (HP:0003561)1.98078219
124Atelectasis (HP:0100750)1.96938722
125Decreased circulating renin level (HP:0003351)1.96532488
126Congenital malformation of the right heart (HP:0011723)1.95961886
127Double outlet right ventricle (HP:0001719)1.95961886
128Humeroradial synostosis (HP:0003041)1.95133133
129Synostosis involving the elbow (HP:0003938)1.95133133
130Polyuria (HP:0000103)1.94927067
131Bilateral microphthalmos (HP:0007633)1.94645530
132Delusions (HP:0000746)1.93576385
133Ulnar claw (HP:0001178)1.93475084
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92555571
135Methylmalonic acidemia (HP:0002912)1.92420133
136Abnormal pupillary function (HP:0007686)1.91740711
137Optic nerve hypoplasia (HP:0000609)1.91589618
138Congenital primary aphakia (HP:0007707)1.91556896
139Hyperthyroidism (HP:0000836)1.90875711
140Hypoplasia of the pons (HP:0012110)1.90184767
141Cerebellar dysplasia (HP:0007033)1.90022448
142X-linked dominant inheritance (HP:0001423)1.88749765
143Severe muscular hypotonia (HP:0006829)1.88463554
144Bony spicule pigmentary retinopathy (HP:0007737)1.87864918
145Muscle hypertrophy of the lower extremities (HP:0008968)1.87776113
146Patellar aplasia (HP:0006443)1.86557978
147Clumsiness (HP:0002312)1.85573155
148Overfolded helix (HP:0000396)1.83980996
149Fair hair (HP:0002286)1.83943880
150Aplasia/Hypoplasia of the patella (HP:0006498)1.83439107
151Hypoplasia of the fovea (HP:0007750)1.83092456
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.83092456
153Aplasia cutis congenita (HP:0001057)1.82904924
154Autoamputation (HP:0001218)1.82741411
155Aplasia involving bones of the extremities (HP:0009825)1.82332447
156Aplasia involving bones of the upper limbs (HP:0009823)1.82332447
157Aplasia of the phalanges of the hand (HP:0009802)1.82332447
158Abnormality of salivation (HP:0100755)1.82303187
159Polyphagia (HP:0002591)1.82068495
160Generalized myoclonic seizures (HP:0002123)1.80921797
161Cerebral hemorrhage (HP:0001342)1.79513892
162Postaxial foot polydactyly (HP:0001830)1.79305681
163Gastroesophageal reflux (HP:0002020)1.78706249
164Anxiety (HP:0000739)1.77016313
165Nephrogenic diabetes insipidus (HP:0009806)1.75564327
1663-Methylglutaconic aciduria (HP:0003535)1.73742856
167Aplasia/Hypoplasia of the spleen (HP:0010451)1.72307573
168Retinitis pigmentosa (HP:0000510)1.71784466
169Rib fusion (HP:0000902)1.68652379
170Tachypnea (HP:0002789)1.68421977
171Ketosis (HP:0001946)1.68033875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.96943097
2PNCK4.19050320
3CASK3.88439818
4EPHA43.33426188
5STK392.93735826
6ZAK2.83387693
7ACVR1B2.72608473
8TNIK2.58614881
9NTRK32.57649081
10RIPK42.55736054
11PINK12.40278029
12MAP4K22.36978672
13FGR2.28533287
14OXSR12.13837770
15NUAK12.10592393
16TLK12.06608977
17MAP3K41.98524703
18GRK71.94634360
19MAP2K71.86392060
20TAOK31.81573726
21NME11.79463894
22GRK51.78510195
23MAP3K121.78272606
24MARK11.74328262
25NTRK11.67778332
26NTRK21.67008665
27MUSK1.55282148
28PLK21.53883587
29MAPKAPK51.53589599
30BMPR21.51760648
31TXK1.48656294
32BCR1.47056960
33FES1.44586355
34PKN11.44380686
35CAMK2B1.43180800
36STK161.43116302
37WNK41.42641558
38MAP3K91.42438438
39MAPK131.36847061
40CAMK2A1.36264440
41MST41.35642282
42BMPR1B1.30879122
43SIK21.26658322
44ADRBK21.19804848
45TGFBR11.19688883
46UHMK11.18623476
47MAP2K41.17585288
48MINK11.14091800
49ARAF1.13914542
50CSNK1G31.13354044
51PTK2B1.10615244
52CSNK1G21.07896969
53ROCK21.05115259
54CAMK2D1.02164126
55CDK191.01407220
56VRK20.99649156
57CDK50.98603549
58TRIM280.97846488
59MAPK150.96640876
60PRKCE0.95863635
61CAMKK20.95227710
62VRK10.94024383
63DYRK1A0.90783244
64PBK0.87971446
65GRK60.87605037
66MAP3K130.86561324
67ADRBK10.86379706
68STK38L0.85996515
69WNK10.84790263
70CSNK1G10.84430212
71BCKDK0.84248802
72PAK30.83958083
73GRK10.82735682
74STK30.80795632
75PRKCG0.80174763
76BRSK20.79202511
77TIE10.78726972
78PAK60.72399865
79CSNK1A1L0.72131984
80NEK60.71329223
81BLK0.71237572
82DYRK20.68409245
83CAMK1G0.68264033
84CAMK2G0.67080145
85PRKCQ0.65377646
86TNK20.64791337
87PIK3CA0.64128569
88WEE10.63734048
89KIT0.63691760
90TEC0.63494080
91CDK140.63220896
92RPS6KA50.62233198
93MKNK20.62054185
94IKBKB0.57881493
95MKNK10.57803413
96CDK150.56480639
97MAPKAPK30.56378829
98PRKACA0.56143978
99STK110.55906284
100FER0.55750671
101CDK180.55194364
102CDK30.55194251
103ERBB30.54921647
104FGFR20.53831162
105WNK30.53669005
106IRAK20.52905870
107PRKG10.52192885
108INSRR0.52146855
109CDK11A0.51956895
110KSR10.51662073
111MAP2K60.51201624
112PHKG20.50030135
113PHKG10.50030135
114PLK30.49436876
115MARK20.47185551
116FYN0.46828727
117CSNK1A10.46419974
118MAP3K60.45996068
119TYRO30.44907829
120PLK40.44300102
121EIF2AK30.43842415
122YES10.43093265
123EPHB20.42897861
124CHEK20.42590316
125CSNK1E0.41989650
126MAPK120.41767965
127MYLK0.41328436
128SGK10.41253054
129MOS0.39709444
130NEK20.38761001
131TAF10.38004735
132MAP2K10.36617516
133IRAK10.35587901
134ITK0.35093007
135ERBB20.34767319
136MST1R0.34693114
137PRKCI0.33870497
138CHUK0.33179591
139ERBB40.33036363
140SYK0.33027065
141RAF10.32945344
142CAMK10.32888299
143CSNK1D0.32819724
144DAPK20.32685494
145PRKAA20.32056532
146PRKCA0.31026472
147RPS6KA60.29936852
148PRKCZ0.29654443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.01708640
2Oxidative phosphorylation_Homo sapiens_hsa001903.85834334
3Parkinsons disease_Homo sapiens_hsa050122.87742198
4Alzheimers disease_Homo sapiens_hsa050102.79612217
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66032991
6Nitrogen metabolism_Homo sapiens_hsa009102.42178103
7Serotonergic synapse_Homo sapiens_hsa047262.35072598
8Glutamatergic synapse_Homo sapiens_hsa047242.27548665
9GABAergic synapse_Homo sapiens_hsa047272.21833766
10Taste transduction_Homo sapiens_hsa047422.16009876
11Collecting duct acid secretion_Homo sapiens_hsa049662.15264356
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.07355817
13Huntingtons disease_Homo sapiens_hsa050162.06661019
14Amphetamine addiction_Homo sapiens_hsa050312.03724667
15Morphine addiction_Homo sapiens_hsa050322.02931096
16Caffeine metabolism_Homo sapiens_hsa002322.01727529
17Cardiac muscle contraction_Homo sapiens_hsa042601.99437559
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98374363
19Tryptophan metabolism_Homo sapiens_hsa003801.97580579
20Selenocompound metabolism_Homo sapiens_hsa004501.95126481
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.93527405
22Phototransduction_Homo sapiens_hsa047441.90695516
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86852533
24* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85952204
25Long-term potentiation_Homo sapiens_hsa047201.85916864
26Long-term depression_Homo sapiens_hsa047301.81884000
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78786666
28Circadian entrainment_Homo sapiens_hsa047131.76801039
29Salivary secretion_Homo sapiens_hsa049701.76176477
30Dopaminergic synapse_Homo sapiens_hsa047281.73637260
31Homologous recombination_Homo sapiens_hsa034401.72564609
32Renin secretion_Homo sapiens_hsa049241.71882358
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67357486
34Synaptic vesicle cycle_Homo sapiens_hsa047211.63053601
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62624192
36Cocaine addiction_Homo sapiens_hsa050301.62246294
37RNA polymerase_Homo sapiens_hsa030201.59728461
38Axon guidance_Homo sapiens_hsa043601.57022521
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54778734
40Calcium signaling pathway_Homo sapiens_hsa040201.48977070
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46730338
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.40058231
43Fatty acid elongation_Homo sapiens_hsa000621.39064654
44Ether lipid metabolism_Homo sapiens_hsa005651.37162750
45Basal transcription factors_Homo sapiens_hsa030221.33028884
46Gastric acid secretion_Homo sapiens_hsa049711.31611280
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27944711
48Cholinergic synapse_Homo sapiens_hsa047251.26823756
49Chemical carcinogenesis_Homo sapiens_hsa052041.24919306
50Propanoate metabolism_Homo sapiens_hsa006401.22740690
51Retinol metabolism_Homo sapiens_hsa008301.21773773
52Olfactory transduction_Homo sapiens_hsa047401.19075592
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.18724970
54Fanconi anemia pathway_Homo sapiens_hsa034601.18516416
55Oxytocin signaling pathway_Homo sapiens_hsa049211.18007742
56ABC transporters_Homo sapiens_hsa020101.17535195
57Vibrio cholerae infection_Homo sapiens_hsa051101.15343910
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14764366
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08263904
60Steroid biosynthesis_Homo sapiens_hsa001001.07677431
61RNA degradation_Homo sapiens_hsa030181.03111409
62Peroxisome_Homo sapiens_hsa041461.02206680
63Insulin secretion_Homo sapiens_hsa049111.01733398
64One carbon pool by folate_Homo sapiens_hsa006700.99215316
65Gap junction_Homo sapiens_hsa045400.97588215
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95656623
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.95542905
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95108134
69GnRH signaling pathway_Homo sapiens_hsa049120.95091372
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93674258
71Protein export_Homo sapiens_hsa030600.91226704
72Melanogenesis_Homo sapiens_hsa049160.88138300
73Sphingolipid metabolism_Homo sapiens_hsa006000.87948086
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87867827
75Ribosome_Homo sapiens_hsa030100.87845965
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86983823
77African trypanosomiasis_Homo sapiens_hsa051430.86970477
78Rheumatoid arthritis_Homo sapiens_hsa053230.86346609
79Pancreatic secretion_Homo sapiens_hsa049720.85768246
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84433899
81cAMP signaling pathway_Homo sapiens_hsa040240.81249553
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81205008
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78655390
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76714945
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76059490
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75034766
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74122916
88Purine metabolism_Homo sapiens_hsa002300.71212834
89Dorso-ventral axis formation_Homo sapiens_hsa043200.70060429
90Glycerolipid metabolism_Homo sapiens_hsa005610.69222602
91Fat digestion and absorption_Homo sapiens_hsa049750.68597221
92Sulfur metabolism_Homo sapiens_hsa009200.67514677
93Asthma_Homo sapiens_hsa053100.67313058
94Regulation of autophagy_Homo sapiens_hsa041400.64215318
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64009573
96Estrogen signaling pathway_Homo sapiens_hsa049150.63552871
97beta-Alanine metabolism_Homo sapiens_hsa004100.63375876
98Histidine metabolism_Homo sapiens_hsa003400.61869528
99Tyrosine metabolism_Homo sapiens_hsa003500.61074231
100Vitamin digestion and absorption_Homo sapiens_hsa049770.60988114
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59867469
102Ras signaling pathway_Homo sapiens_hsa040140.59667380
103Linoleic acid metabolism_Homo sapiens_hsa005910.59484961
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59003246
105Circadian rhythm_Homo sapiens_hsa047100.57267121
106Fatty acid biosynthesis_Homo sapiens_hsa000610.54005992
107Butanoate metabolism_Homo sapiens_hsa006500.53949322
108Wnt signaling pathway_Homo sapiens_hsa043100.51671514
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.51398322
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51115221
111Sulfur relay system_Homo sapiens_hsa041220.50744537
112Choline metabolism in cancer_Homo sapiens_hsa052310.50272006
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.50067260
114Ovarian steroidogenesis_Homo sapiens_hsa049130.48499886
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46901387
116Type I diabetes mellitus_Homo sapiens_hsa049400.46500695
117Primary immunodeficiency_Homo sapiens_hsa053400.46182699
118Hedgehog signaling pathway_Homo sapiens_hsa043400.45809761
119Mineral absorption_Homo sapiens_hsa049780.45752396
120ErbB signaling pathway_Homo sapiens_hsa040120.44076795
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43941207
122Alcoholism_Homo sapiens_hsa050340.42539256
123Pyrimidine metabolism_Homo sapiens_hsa002400.41723992
124Dilated cardiomyopathy_Homo sapiens_hsa054140.41392476
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41264625
126MAPK signaling pathway_Homo sapiens_hsa040100.39682505
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39223285
128Thyroid hormone synthesis_Homo sapiens_hsa049180.38113801
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37742333
130Autoimmune thyroid disease_Homo sapiens_hsa053200.37656821
131Phenylalanine metabolism_Homo sapiens_hsa003600.36769872
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.36366103
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36277334
134Graft-versus-host disease_Homo sapiens_hsa053320.36052162
135Phagosome_Homo sapiens_hsa041450.35518280
136Renal cell carcinoma_Homo sapiens_hsa052110.35023587
137Arachidonic acid metabolism_Homo sapiens_hsa005900.34533256
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33918201
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.31007377
140Rap1 signaling pathway_Homo sapiens_hsa040150.30619952
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.29250936
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26451061
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26293374
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24183413
145Prion diseases_Homo sapiens_hsa050200.22727842
146Metabolic pathways_Homo sapiens_hsa011000.22045973
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20553527

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