NPHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.99111813
2binding of sperm to zona pellucida (GO:0007339)9.83085065
3acrosome reaction (GO:0007340)9.81344891
4cell-cell recognition (GO:0009988)9.49840038
5cell wall macromolecule catabolic process (GO:0016998)9.49297729
6cell wall macromolecule metabolic process (GO:0044036)9.49297729
7male meiosis (GO:0007140)9.46039711
8epithelial cilium movement (GO:0003351)9.38790690
9plasma membrane fusion (GO:0045026)9.38783848
10spermatid development (GO:0007286)9.00565933
11motile cilium assembly (GO:0044458)8.98205694
12synaptonemal complex organization (GO:0070193)8.84695920
13cilium movement (GO:0003341)8.53659780
14synaptonemal complex assembly (GO:0007130)8.41878499
15reproduction (GO:0000003)8.24349390
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.20615798
17regulation of cilium movement (GO:0003352)7.79620295
18single fertilization (GO:0007338)6.86003536
19DNA methylation involved in gamete generation (GO:0043046)6.59344974
20sperm capacitation (GO:0048240)6.37962195
21male meiosis I (GO:0007141)6.28418960
22negative regulation of inclusion body assembly (GO:0090084)6.20078232
23fertilization (GO:0009566)6.13830916
24spermatogenesis (GO:0007283)5.89174452
25male gamete generation (GO:0048232)5.87063602
26chromosome organization involved in meiosis (GO:0070192)5.85870326
27ventricular system development (GO:0021591)5.65002636
28meiotic nuclear division (GO:0007126)5.49575480
29gamete generation (GO:0007276)5.39680961
30germ cell development (GO:0007281)5.27606172
31organic cation transport (GO:0015695)5.26727784
32* cellular process involved in reproduction in multicellular organism (GO:0022412)5.17303964
33meiosis I (GO:0007127)5.12347804
34regulation of inclusion body assembly (GO:0090083)4.99523145
35seminiferous tubule development (GO:0072520)4.96010066
36microtubule severing (GO:0051013)4.89734651
37regulation of microtubule-based movement (GO:0060632)4.72315352
38cell recognition (GO:0008037)4.51147433
39protein localization to cilium (GO:0061512)4.48262817
40microtubule depolymerization (GO:0007019)4.48216249
41meiotic cell cycle (GO:0051321)4.44697957
42calcium ion-dependent exocytosis (GO:0017156)4.40270092
43left/right pattern formation (GO:0060972)4.37547804
44intraciliary transport (GO:0042073)4.27014231
45genitalia morphogenesis (GO:0035112)4.25951581
46multicellular organismal reproductive process (GO:0048609)4.24893492
47monoubiquitinated protein deubiquitination (GO:0035520)4.08587406
48gene silencing by RNA (GO:0031047)4.01659094
49protein polyglutamylation (GO:0018095)3.91587568
50spermatid nucleus differentiation (GO:0007289)3.85059424
51axoneme assembly (GO:0035082)3.84037215
52microtubule bundle formation (GO:0001578)3.75618790
53nonmotile primary cilium assembly (GO:0035058)3.69558946
54chaperone-mediated protein complex assembly (GO:0051131)3.66060453
55chromosome condensation (GO:0030261)3.56543006
56negative regulation of organelle assembly (GO:1902116)3.56182958
57meiotic cell cycle process (GO:1903046)3.53958534
58behavioral response to nicotine (GO:0035095)3.51444972
59DNA packaging (GO:0006323)3.50921416
60regulation of centriole replication (GO:0046599)3.45179081
61nuclear pore complex assembly (GO:0051292)3.44439979
62multicellular organismal development (GO:0007275)3.43654245
63synapsis (GO:0007129)3.41512142
64regulation of meiosis I (GO:0060631)3.38439588
65carnitine transport (GO:0015879)3.36763713
66amino-acid betaine transport (GO:0015838)3.36763713
67regulation of skeletal muscle contraction (GO:0014819)3.36060573
68glycerol ether metabolic process (GO:0006662)3.36059964
69microtubule-based movement (GO:0007018)3.34614600
70carnitine transmembrane transport (GO:1902603)3.30569793
71protein refolding (GO:0042026)3.23980085
72lactate metabolic process (GO:0006089)3.19593114
73smoothened signaling pathway (GO:0007224)3.12947153
74ether metabolic process (GO:0018904)3.12686061
75determination of left/right symmetry (GO:0007368)3.11194605
76regulation of spindle checkpoint (GO:0090231)3.10734977
77neuronal action potential propagation (GO:0019227)3.07373571
78cell projection assembly (GO:0030031)3.07068399
79cilium assembly (GO:0042384)3.05815534
80* cilium organization (GO:0044782)3.04016928
81ubiquinone biosynthetic process (GO:0006744)3.03376456
82mitotic sister chromatid cohesion (GO:0007064)3.02333479
83photoreceptor cell maintenance (GO:0045494)3.00668574
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00159358
85cilium morphogenesis (GO:0060271)2.98810796
86cellular component assembly involved in morphogenesis (GO:0010927)2.98281259
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97680692
88determination of bilateral symmetry (GO:0009855)2.92895878
89muscle filament sliding (GO:0030049)2.92833322
90actin-myosin filament sliding (GO:0033275)2.92833322
91nucleoside diphosphate phosphorylation (GO:0006165)2.88676073
92gene silencing (GO:0016458)2.88506391
93specification of symmetry (GO:0009799)2.86793607
94otic vesicle formation (GO:0030916)2.84099663
95ubiquinone metabolic process (GO:0006743)2.82605785
96centriole replication (GO:0007099)2.82508070
97regulation of hexokinase activity (GO:1903299)2.81717241
98regulation of glucokinase activity (GO:0033131)2.81717241
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80251433
100nuclear pore organization (GO:0006999)2.78427949
101nucleus organization (GO:0006997)2.77280212
102cornea development in camera-type eye (GO:0061303)2.72903374
103glycolytic process (GO:0006096)2.72876089
104centriole assembly (GO:0098534)2.72048825
105regulation of protein polyubiquitination (GO:1902914)2.69605262
106protein complex biogenesis (GO:0070271)2.67632888
107negative regulation of DNA repair (GO:0045738)2.67524325
108nephron epithelium morphogenesis (GO:0072088)2.67186134
109nephron tubule morphogenesis (GO:0072078)2.67186134
110cytoplasmic microtubule organization (GO:0031122)2.66106701
111pore complex assembly (GO:0046931)2.64990540
112retinal cone cell development (GO:0046549)2.64520851
113skeletal muscle contraction (GO:0003009)2.63699588
114detection of light stimulus involved in sensory perception (GO:0050962)2.62872010
115detection of light stimulus involved in visual perception (GO:0050908)2.62872010
116DNA alkylation (GO:0006305)2.60101370
117DNA methylation (GO:0006306)2.60101370
118left/right axis specification (GO:0070986)2.59570287
119spinal cord motor neuron differentiation (GO:0021522)2.59427951
120limb development (GO:0060173)2.58157488
121appendage development (GO:0048736)2.58157488
122GTP biosynthetic process (GO:0006183)2.58116725
123histone exchange (GO:0043486)2.57079001
124sarcoplasmic reticulum calcium ion transport (GO:0070296)2.56892717
125peptidyl-glutamic acid modification (GO:0018200)2.54273559
126L-fucose catabolic process (GO:0042355)2.54217657
127fucose catabolic process (GO:0019317)2.54217657
128L-fucose metabolic process (GO:0042354)2.54217657
129response to pheromone (GO:0019236)2.53608110
130actin-mediated cell contraction (GO:0070252)2.53461477
131polyol catabolic process (GO:0046174)2.51940884
132alditol metabolic process (GO:0019400)2.51320832
133inner ear receptor stereocilium organization (GO:0060122)2.49751621
134platelet dense granule organization (GO:0060155)2.47148601
135regulation of relaxation of muscle (GO:1901077)2.47137388
136renal tubule morphogenesis (GO:0061333)2.46370902
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.43673502
138NADH dehydrogenase complex assembly (GO:0010257)2.43673502
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43673502
140negative regulation of T cell differentiation in thymus (GO:0033085)2.43153751
141exogenous drug catabolic process (GO:0042738)2.42554471
142one-carbon compound transport (GO:0019755)2.40890585
143quinone biosynthetic process (GO:1901663)2.38955667
144somite development (GO:0061053)2.38449500
145neuronal action potential (GO:0019228)2.37260131
146mitochondrial respiratory chain complex assembly (GO:0033108)2.36603462
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36535080
148primary alcohol catabolic process (GO:0034310)2.35738831
149auditory receptor cell stereocilium organization (GO:0060088)2.33895609
150organelle assembly (GO:0070925)2.33835888
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.31233912
152neuron fate determination (GO:0048664)2.30284415
153establishment of protein localization to mitochondrial membrane (GO:0090151)2.28939200
154cellular ketone body metabolic process (GO:0046950)2.28440308
155electron transport chain (GO:0022900)2.28033658
156dopamine transport (GO:0015872)2.27891605
157glutathione derivative metabolic process (GO:1901685)2.25105715
158glutathione derivative biosynthetic process (GO:1901687)2.25105715
159lateral ventricle development (GO:0021670)2.24164405
160positive regulation of mitochondrial fission (GO:0090141)2.24145687
161regulation of collateral sprouting (GO:0048670)2.23503745
162positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.23489234
163photoreceptor cell development (GO:0042461)2.23148001
164neural tube formation (GO:0001841)2.21312466
165myofibril assembly (GO:0030239)2.20933063
166vitamin transmembrane transport (GO:0035461)2.20285473
167regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.19171512
168cilium or flagellum-dependent cell motility (GO:0001539)13.9680483
169fusion of sperm to egg plasma membrane (GO:0007342)12.3271535
170sperm motility (GO:0030317)11.6542998
171acrosome assembly (GO:0001675)11.0164258
172sperm-egg recognition (GO:0035036)10.6581192
173axonemal dynein complex assembly (GO:0070286)10.5809340
174piRNA metabolic process (GO:0034587)10.1986061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24094840
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.47730777
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25829680
4GBX2_23144817_ChIP-Seq_PC3_Human2.83317762
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76203292
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.56571485
7ZNF274_21170338_ChIP-Seq_K562_Hela2.45065553
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34583078
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33969335
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33019371
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32437282
12FUS_26573619_Chip-Seq_HEK293_Human2.25409336
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25261045
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20618546
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18213848
16IGF1R_20145208_ChIP-Seq_DFB_Human2.14065386
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.08372137
18TAF15_26573619_Chip-Seq_HEK293_Human2.02023380
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6763665
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99780965
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94252046
22EWS_26573619_Chip-Seq_HEK293_Human1.93196797
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92326415
24P300_19829295_ChIP-Seq_ESCs_Human1.90861374
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.89169530
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87387525
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.82968355
28ER_23166858_ChIP-Seq_MCF-7_Human1.80849876
29VDR_22108803_ChIP-Seq_LS180_Human1.77077392
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74286008
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73880779
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72544792
33SMAD4_21799915_ChIP-Seq_A2780_Human1.71191459
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68105569
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66661641
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63882117
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61632832
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.60022291
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59637032
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59534321
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59420850
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58264560
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57860044
44STAT3_23295773_ChIP-Seq_U87_Human1.56647988
45BCAT_22108803_ChIP-Seq_LS180_Human1.55334876
46CBP_20019798_ChIP-Seq_JUKART_Human1.52090839
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52090839
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.49521852
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48540503
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46211198
51STAT1_17558387_ChIP-Seq_HELA_Human1.45929975
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45548991
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45502330
54AR_25329375_ChIP-Seq_VCAP_Human1.44884006
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.44283049
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40437183
57* TCF4_23295773_ChIP-Seq_U87_Human1.37976461
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36145729
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36010376
60* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35416022
61NANOG_19829295_ChIP-Seq_ESCs_Human1.35044631
62SOX2_19829295_ChIP-Seq_ESCs_Human1.35044631
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35011363
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33818285
65TCF4_22108803_ChIP-Seq_LS180_Human1.33813716
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32174829
67GATA3_21867929_ChIP-Seq_CD8_Mouse1.30888436
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29454219
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.26557681
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26527605
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24917465
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.24917465
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23753738
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23592471
75RUNX2_22187159_ChIP-Seq_PCA_Human1.23009972
76AR_21572438_ChIP-Seq_LNCaP_Human1.22406710
77TP53_22573176_ChIP-Seq_HFKS_Human1.21817054
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21696150
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.20710146
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.19199668
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.18713068
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18708695
83P53_21459846_ChIP-Seq_SAOS-2_Human1.18707011
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17824880
85KDM2B_26808549_Chip-Seq_REH_Human1.17660808
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17645878
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17190500
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15685480
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14916824
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14852847
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14516216
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14461176
93AR_20517297_ChIP-Seq_VCAP_Human1.13611622
94DROSHA_22980978_ChIP-Seq_HELA_Human1.12529004
95CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11652062
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11441352
97IRF1_19129219_ChIP-ChIP_H3396_Human1.08768970
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08432704
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06422257
100ERG_20517297_ChIP-Seq_VCAP_Human1.06389445
101RNF2_27304074_Chip-Seq_NSC_Mouse1.05319476
102PHF8_20622853_ChIP-Seq_HELA_Human1.05115687
103GF1_26923725_Chip-Seq_HPCs_Mouse1.05015135
104NCOR_22424771_ChIP-Seq_293T_Human1.04729143
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04202257
106CDX2_22108803_ChIP-Seq_LS180_Human1.03526143
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03475749
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.03050665
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02764580
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02359813
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02142255
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01548933
113ETV1_20927104_ChIP-Seq_GIST48_Human1.00742648
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99402123
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99402123
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.99326419
117GABP_17652178_ChIP-ChIP_JURKAT_Human0.99313778
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99235218
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99067339
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98339948
121TBL1_22424771_ChIP-Seq_293T_Human0.98300738
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.96158849
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.95605102
124SPI1_26923725_Chip-Seq_HPCs_Mouse0.95446917
125REST_21632747_ChIP-Seq_MESCs_Mouse0.95217167
126* GATA3_21867929_ChIP-Seq_TH1_Mouse0.94883248
127* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94785499
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.94780321
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94366493
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.94307069
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.93252401
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91728191
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91677862
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90994394
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90336153
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.89771990
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.89732055
138* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89055034
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.87977244
140SOX2_21211035_ChIP-Seq_LN229_Human0.87267429
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87121810
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87071778
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86758994
144* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86603800
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86206355
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85583945
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.85489921
148P53_22387025_ChIP-Seq_ESCs_Mouse0.84974432
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.84656016
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84326439
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84284019
152NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83540609
153RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83002338
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.82034134
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81707666
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81208830
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.80435291
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.79779690
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.78437597
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.77722028
161PHF8_20622854_ChIP-Seq_HELA_Human0.77452047
162* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.76940030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.69977053
2MP0008877_abnormal_DNA_methylation5.59138933
3* MP0001929_abnormal_gametogenesis5.33764976
4* MP0002210_abnormal_sex_determination3.72599964
5MP0002653_abnormal_ependyma_morphology3.33731798
6* MP0001145_abnormal_male_reproductive3.15142062
7* MP0002161_abnormal_fertility/fecundity3.09178194
8* MP0000653_abnormal_sex_gland2.74833137
9MP0003136_yellow_coat_color2.64011900
10MP0005623_abnormal_meninges_morphology2.48086677
11MP0008875_abnormal_xenobiotic_pharmacok2.40935069
12MP0002160_abnormal_reproductive_system2.30311702
13MP0005551_abnormal_eye_electrophysiolog2.07708515
14MP0005410_abnormal_fertilization14.3349512
15MP0002638_abnormal_pupillary_reflex1.99416122
16MP0008789_abnormal_olfactory_epithelium1.97849593
17MP0005670_abnormal_white_adipose1.88519962
18MP0003646_muscle_fatigue1.87026364
19MP0002938_white_spotting1.75798258
20MP0001485_abnormal_pinna_reflex1.74012920
21MP0008057_abnormal_DNA_replication1.69831324
22MP0003195_calcinosis1.67086884
23MP0004233_abnormal_muscle_weight1.65459469
24MP0000372_irregular_coat_pigmentation1.59051487
25MP0002282_abnormal_trachea_morphology1.53322910
26MP0003880_abnormal_central_pattern1.52583611
27MP0005646_abnormal_pituitary_gland1.51970592
28MP0004885_abnormal_endolymph1.47912353
29MP0002277_abnormal_respiratory_mucosa1.47505052
30MP0000631_abnormal_neuroendocrine_gland1.45443499
31MP0004142_abnormal_muscle_tone1.43584226
32MP0004147_increased_porphyrin_level1.41260108
33MP0006276_abnormal_autonomic_nervous1.40125746
34MP0005645_abnormal_hypothalamus_physiol1.39038242
35MP0009745_abnormal_behavioral_response1.35901831
36MP0002272_abnormal_nervous_system1.35727730
37MP0006292_abnormal_olfactory_placode1.35491042
38MP0004215_abnormal_myocardial_fiber1.33079734
39MP0002876_abnormal_thyroid_physiology1.29286178
40MP0001529_abnormal_vocalization1.26455164
41MP0008058_abnormal_DNA_repair1.26453210
42MP0002736_abnormal_nociception_after1.26256304
43MP0000383_abnormal_hair_follicle1.26082601
44MP0001486_abnormal_startle_reflex1.23911452
45MP0005389_reproductive_system_phenotype1.21011495
46MP0008872_abnormal_physiological_respon1.20959887
47MP0000026_abnormal_inner_ear1.20938293
48MP0010094_abnormal_chromosome_stability1.19144942
49MP0002734_abnormal_mechanical_nocicepti1.17575271
50MP0005394_taste/olfaction_phenotype1.16658096
51MP0005499_abnormal_olfactory_system1.16658096
52MP0009780_abnormal_chondrocyte_physiolo1.16277571
53MP0001968_abnormal_touch/_nociception1.11931658
54MP0008995_early_reproductive_senescence1.11800883
55MP0005620_abnormal_muscle_contractility1.11203473
56MP0001765_abnormal_ion_homeostasis1.09750917
57MP0008007_abnormal_cellular_replicative1.06926927
58MP0010030_abnormal_orbit_morphology1.05795424
59MP0000566_synostosis1.04039741
60MP0002067_abnormal_sensory_capabilities1.03119667
61MP0005369_muscle_phenotype1.02757204
62MP0005647_abnormal_sex_gland0.97911987
63MP0001502_abnormal_circadian_rhythm0.97801454
64MP0003937_abnormal_limbs/digits/tail_de0.97218881
65MP0003786_premature_aging0.95628641
66MP0002572_abnormal_emotion/affect_behav0.94895470
67MP0005377_hearing/vestibular/ear_phenot0.94099021
68MP0003878_abnormal_ear_physiology0.94099021
69MP0002557_abnormal_social/conspecific_i0.93656169
70MP0005084_abnormal_gallbladder_morpholo0.92912204
71MP0001984_abnormal_olfaction0.92755251
72* MP0005195_abnormal_posterior_eye0.92725770
73MP0002752_abnormal_somatic_nervous0.92472168
74MP0000049_abnormal_middle_ear0.92239578
75MP0002233_abnormal_nose_morphology0.92237637
76MP0005171_absent_coat_pigmentation0.91479866
77MP0002234_abnormal_pharynx_morphology0.91357257
78MP0003137_abnormal_impulse_conducting0.91164048
79MP0001963_abnormal_hearing_physiology0.91139556
80MP0002332_abnormal_exercise_endurance0.90137379
81MP0004084_abnormal_cardiac_muscle0.89005636
82MP0002822_catalepsy0.87687002
83MP0003115_abnormal_respiratory_system0.87329925
84MP0001501_abnormal_sleep_pattern0.86550006
85MP0005083_abnormal_biliary_tract0.84495731
86MP0000778_abnormal_nervous_system0.84059456
87MP0008775_abnormal_heart_ventricle0.83366862
88MP0004085_abnormal_heartbeat0.81901249
89MP0004134_abnormal_chest_morphology0.80106936
90MP0004130_abnormal_muscle_cell0.79882882
91MP0003718_maternal_effect0.79127104
92MP0005174_abnormal_tail_pigmentation0.77535817
93MP0005187_abnormal_penis_morphology0.77352322
94MP0001970_abnormal_pain_threshold0.77087092
95MP0009046_muscle_twitch0.73335303
96MP0002928_abnormal_bile_duct0.73267232
97MP0000358_abnormal_cell_content/0.69837190
98MP0001293_anophthalmia0.69165309
99MP0000569_abnormal_digit_pigmentation0.65714221
100MP0000751_myopathy0.65659850
101MP0003111_abnormal_nucleus_morphology0.64104733
102MP0003011_delayed_dark_adaptation0.63724106
103MP0003950_abnormal_plasma_membrane0.63118498
104MP0003942_abnormal_urinary_system0.62759682
105MP0003283_abnormal_digestive_organ0.60368325
106MP0004808_abnormal_hematopoietic_stem0.59932466
107MP0001730_embryonic_growth_arrest0.59817140
108MP0002269_muscular_atrophy0.58727383
109MP0010307_abnormal_tumor_latency0.58288248
110MP0003699_abnormal_female_reproductive0.57599419
111MP0005636_abnormal_mineral_homeostasis0.56452079
112MP0005666_abnormal_adipose_tissue0.56320559
113MP0009278_abnormal_bone_marrow0.56185974
114MP0004036_abnormal_muscle_relaxation0.55074505
115MP0002084_abnormal_developmental_patter0.52929470
116MP0004133_heterotaxia0.52635365
117MP0004043_abnormal_pH_regulation0.51205153
118MP0001545_abnormal_hematopoietic_system0.49675697
119MP0005397_hematopoietic_system_phenotyp0.49675697
120MP0000534_abnormal_ureter_morphology0.49135250
121MP0001119_abnormal_female_reproductive0.48593282
122MP0008961_abnormal_basal_metabolism0.48012905
123MP0005391_vision/eye_phenotype0.46191875
124MP0002092_abnormal_eye_morphology0.43413328
125MP0001324_abnormal_eye_pigmentation0.42491220
126MP0005253_abnormal_eye_physiology0.42083159
127MP0002108_abnormal_muscle_morphology0.40319706
128MP0001849_ear_inflammation0.40249929
129MP0006036_abnormal_mitochondrial_physio0.39802309
130MP0000013_abnormal_adipose_tissue0.39766768
131MP0001727_abnormal_embryo_implantation0.39442644
132MP0000427_abnormal_hair_cycle0.38887229
133MP0003077_abnormal_cell_cycle0.38656148
134MP0006072_abnormal_retinal_apoptosis0.38557791
135MP0003861_abnormal_nervous_system0.37977603
136MP0004145_abnormal_muscle_electrophysio0.37827213
137MP0002102_abnormal_ear_morphology0.36129626
138MP0005503_abnormal_tendon_morphology0.35478868
139MP0000537_abnormal_urethra_morphology0.35391482
140MP0001697_abnormal_embryo_size0.34883244
141MP0002085_abnormal_embryonic_tissue0.33782068
142MP0000313_abnormal_cell_death0.32450825
143MP0002837_dystrophic_cardiac_calcinosis0.32277692
144MP0009250_abnormal_appendicular_skeleto0.31417419
145MP0000432_abnormal_head_morphology0.31180038
146MP0001672_abnormal_embryogenesis/_devel0.31151230
147MP0005380_embryogenesis_phenotype0.31151230
148MP0000749_muscle_degeneration0.30809009
149MP0004197_abnormal_fetal_growth/weight/0.30690009
150MP0002116_abnormal_craniofacial_bone0.30182732
151MP0002971_abnormal_brown_adipose0.30093864
152MP0003045_fibrosis0.29231754
153MP0005375_adipose_tissue_phenotype0.28471799
154MP0002697_abnormal_eye_size0.27147456
155MP0002080_prenatal_lethality0.26097783
156MP0002152_abnormal_brain_morphology0.25891044
157MP0001661_extended_life_span0.25776352
158MP0002106_abnormal_muscle_physiology0.25753010
159MP0009672_abnormal_birth_weight0.25568181
160MP0009115_abnormal_fat_cell0.25312920
161MP0003329_amyloid_beta_deposits0.24856942
162MP0002109_abnormal_limb_morphology0.24532189
163MP0003936_abnormal_reproductive_system0.24513674
164MP0005257_abnormal_intraocular_pressure0.24087708

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.55536194
2Abnormal respiratory motile cilium morphology (HP:0005938)8.58593072
3Abnormal respiratory epithelium morphology (HP:0012253)8.58593072
4Rhinitis (HP:0012384)8.24618405
5Abnormal ciliary motility (HP:0012262)7.67028290
6Chronic bronchitis (HP:0004469)7.52437970
7Infertility (HP:0000789)6.36846762
8Nasal polyposis (HP:0100582)6.33635382
9Abnormality of the nasal mucosa (HP:0000433)5.22613142
10Bronchiectasis (HP:0002110)4.78406153
11Pancreatic cysts (HP:0001737)4.58214758
12Bronchitis (HP:0012387)4.50782683
13Abnormality of the lower motor neuron (HP:0002366)3.90643137
14Male infertility (HP:0003251)3.87671150
15* Nephronophthisis (HP:0000090)3.78893248
16Chronic hepatic failure (HP:0100626)3.32696836
17Abnormal spermatogenesis (HP:0008669)3.30396257
18Tubulointerstitial nephritis (HP:0001970)3.20012735
19Recurrent otitis media (HP:0000403)3.17883851
20Muscle fiber inclusion bodies (HP:0100299)3.14439880
21Gonadotropin excess (HP:0000837)3.12103989
22Fibular hypoplasia (HP:0003038)3.04444246
23Nemaline bodies (HP:0003798)2.97470050
24Recurrent sinusitis (HP:0011108)2.93167202
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.92310984
26Amyotrophic lateral sclerosis (HP:0007354)2.90162356
27* Abnormality of the renal medulla (HP:0100957)2.89298749
28Muscle hypertrophy of the lower extremities (HP:0008968)2.84293128
29Sclerocornea (HP:0000647)2.76888726
30Type II lissencephaly (HP:0007260)2.72942629
31Nephrogenic diabetes insipidus (HP:0009806)2.69473374
32Calf muscle hypertrophy (HP:0008981)2.65199548
33Anencephaly (HP:0002323)2.60086269
34Azoospermia (HP:0000027)2.56775154
35Recurrent bronchitis (HP:0002837)2.49679158
36Male pseudohermaphroditism (HP:0000037)2.44351567
37Postaxial foot polydactyly (HP:0001830)2.39605862
38Exercise-induced muscle cramps (HP:0003710)2.39577597
39Degeneration of anterior horn cells (HP:0002398)2.36394062
40Abnormality of the anterior horn cell (HP:0006802)2.36394062
41Genital tract atresia (HP:0001827)2.35074489
42Furrowed tongue (HP:0000221)2.33859704
43* Abnormality of the renal cortex (HP:0011035)2.30467480
44Abnormality of dentin (HP:0010299)2.28596700
45* Tubular atrophy (HP:0000092)2.27385176
46Vaginal atresia (HP:0000148)2.26879554
47Short ribs (HP:0000773)2.22440994
48Impaired proprioception (HP:0010831)2.19465894
49Impulsivity (HP:0100710)2.12144362
50Poor coordination (HP:0002370)2.10741044
51Facial cleft (HP:0002006)2.08741385
5211 pairs of ribs (HP:0000878)2.07622736
53Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.06751046
54Acute necrotizing encephalopathy (HP:0006965)2.05129941
55Upper motor neuron abnormality (HP:0002127)2.02241119
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5644260
57Dynein arm defect of respiratory motile cilia (HP:0012255)11.8948007
58Absent/shortened dynein arms (HP:0200106)11.8948007
59Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99323664
60Microglossia (HP:0000171)1.98454788
61Absent frontal sinuses (HP:0002688)1.96929343
62Abnormality of the dental root (HP:0006486)1.94120055
63Taurodontia (HP:0000679)1.94120055
64Abnormality of permanent molar morphology (HP:0011071)1.94120055
65Aplasia/Hypoplasia of the fibula (HP:0006492)1.93920282
66Renal dysplasia (HP:0000110)1.92478511
67Exercise-induced myalgia (HP:0003738)1.91607824
68Bell-shaped thorax (HP:0001591)1.90780200
69Abnormality of the calf musculature (HP:0001430)1.90195214
70Median cleft lip (HP:0000161)1.88880345
71Short thorax (HP:0010306)1.87108564
72Preaxial hand polydactyly (HP:0001177)1.84809315
73Cystic liver disease (HP:0006706)1.83286554
74Left ventricular hypertrophy (HP:0001712)1.83141010
75Supernumerary spleens (HP:0009799)1.82307871
76Hyperkalemia (HP:0002153)1.81894111
77Abnormality of molar morphology (HP:0011070)1.81782035
78Abnormality of molar (HP:0011077)1.81782035
79Pancreatic fibrosis (HP:0100732)1.79590599
80J-shaped sella turcica (HP:0002680)1.78870267
81Mitochondrial inheritance (HP:0001427)1.77534694
82Abnormal mitochondria in muscle tissue (HP:0008316)1.77518865
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.76176175
84Progressive macrocephaly (HP:0004481)1.75901682
85Abolished electroretinogram (ERG) (HP:0000550)1.75225122
86Abnormality of the dental pulp (HP:0006479)1.74460100
87Type 1 muscle fiber predominance (HP:0003803)1.74018468
88Abnormal rod and cone electroretinograms (HP:0008323)1.73152758
89Congenital stationary night blindness (HP:0007642)1.73085131
90Broad distal phalanx of finger (HP:0009836)1.72852608
91Acute encephalopathy (HP:0006846)1.72686046
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.70128194
93Selective tooth agenesis (HP:0001592)1.68112714
94Distal arthrogryposis (HP:0005684)1.67032787
95Asplenia (HP:0001746)1.66935721
96Chronic sinusitis (HP:0011109)1.66169050
97Rimmed vacuoles (HP:0003805)1.65725432
98Renal cortical cysts (HP:0000803)1.65183098
99Absent epiphyses (HP:0010577)1.63018556
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63018556
101Decreased circulating renin level (HP:0003351)1.61801048
102* Abnormal drinking behavior (HP:0030082)1.61101880
103* Polydipsia (HP:0001959)1.61101880
104Anophthalmia (HP:0000528)1.60535326
105Severe muscular hypotonia (HP:0006829)1.59076817
106Cholecystitis (HP:0001082)1.58918689
107Abnormal gallbladder physiology (HP:0012438)1.58918689
108Large for gestational age (HP:0001520)1.58583478
109Increased CSF lactate (HP:0002490)1.58214434
110Heterotopia (HP:0002282)1.57643816
111Absent phalangeal crease (HP:0006109)1.56901587
112Hepatocellular necrosis (HP:0001404)1.53305842
113Abnormal biliary tract physiology (HP:0012439)1.53144125
114Bile duct proliferation (HP:0001408)1.53144125
115Hemiparesis (HP:0001269)1.53020444
116* Stage 5 chronic kidney disease (HP:0003774)1.52796768
117Hyperventilation (HP:0002883)1.51617732
118True hermaphroditism (HP:0010459)1.51315004
119Hepatic necrosis (HP:0002605)1.51191681
120Specific learning disability (HP:0001328)1.48482897
121Attenuation of retinal blood vessels (HP:0007843)1.48347710
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.48290343
123Decreased central vision (HP:0007663)1.48113332
124Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.47598823
125Abnormal finger flexion creases (HP:0006143)1.47001410
126* Postaxial hand polydactyly (HP:0001162)1.46536494
127Congenital, generalized hypertrichosis (HP:0004540)1.46403084
128* Narrow forehead (HP:0000341)1.45836244
129* Congenital hepatic fibrosis (HP:0002612)1.45620980
130Deformed sella turcica (HP:0002681)1.45607639
131Congenital primary aphakia (HP:0007707)1.45032439
132Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44969491
133Difficulty climbing stairs (HP:0003551)1.44173960
134* Aganglionic megacolon (HP:0002251)1.43964690
135Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42912446
136Chronic otitis media (HP:0000389)1.42796040
137Gait imbalance (HP:0002141)1.41600667
138Abnormality of ocular smooth pursuit (HP:0000617)1.40140714
139* Molar tooth sign on MRI (HP:0002419)1.40055488
140* Abnormality of midbrain morphology (HP:0002418)1.40055488
141Occipital encephalocele (HP:0002085)1.39590780
142Breast carcinoma (HP:0003002)1.39431840
143Short nail (HP:0001799)1.37287966
144* Medial flaring of the eyebrow (HP:0010747)1.36462751
145Cerebellar dysplasia (HP:0007033)1.35919733
146* Tubulointerstitial abnormality (HP:0001969)1.35738692
147Aplasia/Hypoplasia of the lens (HP:0008063)1.35132741
148* Oculomotor apraxia (HP:0000657)1.34580276
149Missing ribs (HP:0000921)1.32347191
150Conjunctival telangiectasia (HP:0000524)1.32230250
151Large eyes (HP:0001090)1.30975756
152Hypoplasia of dental enamel (HP:0006297)1.30503680
153Dyschromatopsia (HP:0007641)1.30217718
154Abnormality of the epiphyses of the hand (HP:0005924)1.29239007
155Pachygyria (HP:0001302)1.28827717
156Short femoral neck (HP:0100864)1.25443450
157Spastic tetraparesis (HP:0001285)1.24095305
158Atrophy/Degeneration involving motor neurons (HP:0007373)1.22888898
159Decreased motor nerve conduction velocity (HP:0003431)1.22773892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.72715942
2PDK48.72715942
3PDK25.55948244
4TESK15.04916037
5PRKD34.27242624
6FRK4.07454303
7ICK3.44018509
8PHKG22.93813169
9PHKG12.93813169
10WNK42.71547132
11PNCK2.34647540
12BMPR1B2.30379946
13NEK22.17261028
14ADRBK22.12833046
15STK392.10269409
16MAP4K22.09924278
17GRK12.03530216
18MST41.93300932
19MAPK151.58748819
20ZAK1.56304832
21STK381.56235215
22TNIK1.51772337
23TRIM281.45542258
24MAPK131.43968696
25NUAK11.41663691
26TLK11.40217365
27INSRR1.40196150
28ERBB31.32627849
29PASK1.31917083
30NME11.28506036
31CASK1.20161412
32BCR1.19936770
33MKNK21.16687840
34CDC71.14614450
35DYRK1B1.14282448
36ACVR1B1.12773647
37VRK11.09913969
38OXSR11.08538237
39TYRO31.06206035
40PLK21.05300178
41WNK11.05113382
42STK31.01112880
43TIE10.99470351
44MARK10.96976523
45TSSK60.94508413
46EPHA40.88793211
47CSNK1G20.88701129
48TTK0.88487233
49DYRK30.85464914
50CSNK1G10.84916890
51ADRBK10.83312450
52PRKCE0.83271219
53TAOK30.83196696
54PDK10.83081235
55WEE10.80567222
56PAK30.78309071
57EEF2K0.76946494
58MAP2K40.76703025
59STK38L0.76498766
60CCNB10.73057728
61STK160.72516959
62NTRK30.71934891
63MAP3K70.67923519
64CAMK2A0.67701360
65PKN10.66273674
66FGFR20.63855289
67CSNK1G30.63796671
68ATR0.61550787
69PLK30.61189511
70PINK10.60619034
71PRKCI0.60057162
72PIK3CG0.59252092
73PRKACA0.56872838
74STK240.56849363
75PRKG10.56325699
76LMTK20.56077399
77CHEK10.55715675
78CHEK20.55273550
79EPHA30.54904273
80NLK0.54482445
81DAPK20.53753457
82TRPM70.53120462
83CAMK1G0.52447223
84LIMK10.51996194
85CAMKK20.51960682
86DYRK20.50306048
87STK110.50147629
88WNK30.49768606
89MKNK10.49059083
90CSNK1A1L0.45331921
91IRAK10.44938204
92MTOR0.43992560
93BRSK20.42973241
94PRKAA20.42917346
95PRKCQ0.42623150
96MAPKAPK50.42495912
97PAK20.41634495
98PLK40.41362763
99TRIB30.41222178
100ATM0.41076375
101NEK10.40987781
102CAMK2G0.40289195
103BCKDK0.39987054
104TGFBR10.39942618
105EPHA20.38081461
106PIK3CA0.37060529
107CDK120.35803634
108CAMK10.34117100
109PDPK10.32960923
110VRK20.32897449
111PLK10.32856618
112NEK90.32265941
113CSNK1A10.32191773
114DYRK1A0.31611906
115PAK10.30870462
116PAK40.28384384
117NTRK20.26863681
118PRKAA10.25244094
119LATS10.25028264
120TTN0.22687008
121MAP3K100.21645488
122TESK20.20797872
123RPS6KB10.20320848
124PRKCG0.20063603
125CAMKK10.19946638
126BRAF0.16272943
127RIPK10.15999918
128MAP2K60.14839610
129BRSK10.14547636
130MAP3K40.13462769
131PTK60.11535275
132CDK20.11273927
133CDK10.11260339
134PRKDC0.09700529
135NEK60.09631913
136PAK60.09621988
137IRAK20.08747912
138MARK20.08614411
139DDR20.08587393
140CDK60.08433214
141MUSK0.08420960
142GSK3B0.06283587
143* PTK2B0.06059292
144AURKA0.05428037
145PDGFRB0.05369937
146MAPK80.04758717
147RPS6KA10.04756129
148AURKB0.03709936
149MAP2K70.03485397
150CSNK2A20.03202682
151TAOK10.03041953
152CDK40.02760623
153CSNK1D0.02066761
154MAPK100.01881423
155MAPKAPK30.01841900
156CDK150.01717290
157PDGFRA0.01462047
158PRKACG0.01218194
159STK100.00974085
160BUB10.00441630
161PRKACB0.00327784
162RPS6KA30.00024930
163CDK14-0.0249797
164OBSCN-0.0240660
165MARK3-0.0151208
166ZAP70-0.0132999
167* CSNK2A1-0.0117432
168CSNK1E-0.0093665
169CDK18-0.0074244
170CDK11A-0.0058868
171MAPK1-0.0052036
172PRKCZ-0.0018383

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006204.24817795
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.11625627
3Vitamin B6 metabolism_Homo sapiens_hsa007503.80359718
4Propanoate metabolism_Homo sapiens_hsa006403.38501241
5Glucagon signaling pathway_Homo sapiens_hsa049222.98547417
6Fatty acid biosynthesis_Homo sapiens_hsa000612.93458245
7Selenocompound metabolism_Homo sapiens_hsa004502.78931836
8Oxidative phosphorylation_Homo sapiens_hsa001902.76275216
9Basal transcription factors_Homo sapiens_hsa030222.69910834
10Dorso-ventral axis formation_Homo sapiens_hsa043202.36619830
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.36453263
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35428017
13Pentose phosphate pathway_Homo sapiens_hsa000302.33136017
14Fanconi anemia pathway_Homo sapiens_hsa034602.27999512
15Parkinsons disease_Homo sapiens_hsa050122.26589788
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22540848
17Linoleic acid metabolism_Homo sapiens_hsa005912.22013099
18Nitrogen metabolism_Homo sapiens_hsa009102.21439469
19Phototransduction_Homo sapiens_hsa047442.20560811
20Oocyte meiosis_Homo sapiens_hsa041142.13241286
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99497577
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86055152
23Protein export_Homo sapiens_hsa030601.84593558
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84047114
25Butanoate metabolism_Homo sapiens_hsa006501.84037268
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76429341
27Histidine metabolism_Homo sapiens_hsa003401.73729074
28beta-Alanine metabolism_Homo sapiens_hsa004101.73605502
29Circadian rhythm_Homo sapiens_hsa047101.71921422
30Huntingtons disease_Homo sapiens_hsa050161.70785089
31Glycerolipid metabolism_Homo sapiens_hsa005611.70454479
32Alzheimers disease_Homo sapiens_hsa050101.66762085
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63634052
34mRNA surveillance pathway_Homo sapiens_hsa030151.61508053
35Amphetamine addiction_Homo sapiens_hsa050311.60116048
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58143173
37Carbon metabolism_Homo sapiens_hsa012001.55544421
38RNA transport_Homo sapiens_hsa030131.55540637
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55214248
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48597711
41Tryptophan metabolism_Homo sapiens_hsa003801.47713809
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.44736324
43Caffeine metabolism_Homo sapiens_hsa002321.42042374
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41933235
45Peroxisome_Homo sapiens_hsa041461.40181333
46PPAR signaling pathway_Homo sapiens_hsa033201.40100147
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38504741
48Nicotine addiction_Homo sapiens_hsa050331.36451325
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35754892
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27649786
51Fructose and mannose metabolism_Homo sapiens_hsa000511.27503063
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27443391
53Retinol metabolism_Homo sapiens_hsa008301.27145476
54RNA polymerase_Homo sapiens_hsa030201.25919926
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25491176
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25365831
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.22672920
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22578812
59Olfactory transduction_Homo sapiens_hsa047401.21320004
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20254994
61Renin secretion_Homo sapiens_hsa049241.19695099
62Glycerophospholipid metabolism_Homo sapiens_hsa005641.16998718
63Cardiac muscle contraction_Homo sapiens_hsa042601.15085761
64Antigen processing and presentation_Homo sapiens_hsa046121.13927022
65Regulation of autophagy_Homo sapiens_hsa041401.13451238
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10487800
67Fatty acid metabolism_Homo sapiens_hsa012121.08856207
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05471111
69Fatty acid degradation_Homo sapiens_hsa000711.05185732
70Primary bile acid biosynthesis_Homo sapiens_hsa001201.04911915
71Fat digestion and absorption_Homo sapiens_hsa049751.03522916
72Biosynthesis of amino acids_Homo sapiens_hsa012301.03096197
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02480550
74Tyrosine metabolism_Homo sapiens_hsa003500.99740060
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98935176
76Arginine and proline metabolism_Homo sapiens_hsa003300.94753496
77Salivary secretion_Homo sapiens_hsa049700.93984055
78Dilated cardiomyopathy_Homo sapiens_hsa054140.93780486
79Purine metabolism_Homo sapiens_hsa002300.93592893
80Phenylalanine metabolism_Homo sapiens_hsa003600.92492986
81Estrogen signaling pathway_Homo sapiens_hsa049150.92000887
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.91450067
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.91417510
84Long-term potentiation_Homo sapiens_hsa047200.85703418
85Circadian entrainment_Homo sapiens_hsa047130.82859764
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81386535
87Mineral absorption_Homo sapiens_hsa049780.81231589
88Hedgehog signaling pathway_Homo sapiens_hsa043400.81189194
89N-Glycan biosynthesis_Homo sapiens_hsa005100.77979409
90Systemic lupus erythematosus_Homo sapiens_hsa053220.77626456
91Glutathione metabolism_Homo sapiens_hsa004800.75973398
92AMPK signaling pathway_Homo sapiens_hsa041520.73914123
93Ether lipid metabolism_Homo sapiens_hsa005650.71893395
94Serotonergic synapse_Homo sapiens_hsa047260.71110391
95Insulin secretion_Homo sapiens_hsa049110.70887541
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70779308
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68380833
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67775096
99Cell cycle_Homo sapiens_hsa041100.66305655
100RNA degradation_Homo sapiens_hsa030180.64732708
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64526066
102Nucleotide excision repair_Homo sapiens_hsa034200.63204716
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.62896581
104Renin-angiotensin system_Homo sapiens_hsa046140.62328092
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61959370
106Thyroid hormone synthesis_Homo sapiens_hsa049180.61353767
107ABC transporters_Homo sapiens_hsa020100.60660424
108Oxytocin signaling pathway_Homo sapiens_hsa049210.59674046
109Ovarian steroidogenesis_Homo sapiens_hsa049130.59580560
110Protein digestion and absorption_Homo sapiens_hsa049740.58247819
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58181555
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56926117
113Alcoholism_Homo sapiens_hsa050340.56738723
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56125929
115Glutamatergic synapse_Homo sapiens_hsa047240.56031654
116Tight junction_Homo sapiens_hsa045300.55825770
117GABAergic synapse_Homo sapiens_hsa047270.54169167
118Homologous recombination_Homo sapiens_hsa034400.53872392
119Collecting duct acid secretion_Homo sapiens_hsa049660.53353563
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52534984
121Starch and sucrose metabolism_Homo sapiens_hsa005000.52256746
122VEGF signaling pathway_Homo sapiens_hsa043700.50641937
123Morphine addiction_Homo sapiens_hsa050320.50619070
124Proteasome_Homo sapiens_hsa030500.49697975
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49158405
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48319860
127Arachidonic acid metabolism_Homo sapiens_hsa005900.44517817
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43274047
129Ribosome_Homo sapiens_hsa030100.43249434
130Legionellosis_Homo sapiens_hsa051340.42301673
131Viral carcinogenesis_Homo sapiens_hsa052030.42205636
132Basal cell carcinoma_Homo sapiens_hsa052170.41666894
133Wnt signaling pathway_Homo sapiens_hsa043100.40999166
134Lysine degradation_Homo sapiens_hsa003100.40629379
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40488237
136Calcium signaling pathway_Homo sapiens_hsa040200.40300140
137Hippo signaling pathway_Homo sapiens_hsa043900.39257792
138Dopaminergic synapse_Homo sapiens_hsa047280.39247600
139Endocytosis_Homo sapiens_hsa041440.37073512
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.33482326
141Chemical carcinogenesis_Homo sapiens_hsa052040.31845668
142Spliceosome_Homo sapiens_hsa030400.31072077
143Inositol phosphate metabolism_Homo sapiens_hsa005620.30621740
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29337604
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29207782
146Pancreatic secretion_Homo sapiens_hsa049720.29031094
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28918240
148Insulin resistance_Homo sapiens_hsa049310.28780006
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28684975
150Bile secretion_Homo sapiens_hsa049760.26907981
151Metabolic pathways_Homo sapiens_hsa011000.26646752
152Pyrimidine metabolism_Homo sapiens_hsa002400.23663645
153Cocaine addiction_Homo sapiens_hsa050300.23403594
154Gastric acid secretion_Homo sapiens_hsa049710.22422708
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.21416666
156DNA replication_Homo sapiens_hsa030300.21287352
157cAMP signaling pathway_Homo sapiens_hsa040240.18872752
158Taste transduction_Homo sapiens_hsa047420.18817923
159Insulin signaling pathway_Homo sapiens_hsa049100.18586288
160HTLV-I infection_Homo sapiens_hsa051660.17556031

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