NPHP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of astrocyte differentiation (GO:0048712)4.90560885
2hyperosmotic salinity response (GO:0042538)4.84474770
3behavioral response to nicotine (GO:0035095)4.07078859
4ovulation cycle (GO:0042698)3.90229173
5low-density lipoprotein particle remodeling (GO:0034374)3.74850367
6L-amino acid import (GO:0043092)3.64170275
7nephron epithelium morphogenesis (GO:0072088)3.60696893
8nephron tubule morphogenesis (GO:0072078)3.60696893
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58305123
10lateral sprouting from an epithelium (GO:0060601)3.54834227
11atrial cardiac muscle cell action potential (GO:0086014)3.53393262
12amino acid import (GO:0043090)3.49088870
13cellular response to cholesterol (GO:0071397)3.45796361
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45324399
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.45324399
16regulation of translation, ncRNA-mediated (GO:0045974)3.45324399
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44485778
18cellular potassium ion homeostasis (GO:0030007)3.40606941
19establishment of protein localization to Golgi (GO:0072600)3.38062072
20indole-containing compound catabolic process (GO:0042436)3.33534584
21indolalkylamine catabolic process (GO:0046218)3.33534584
22tryptophan catabolic process (GO:0006569)3.33534584
23one-carbon compound transport (GO:0019755)3.33220858
24* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31057607
25dermatan sulfate metabolic process (GO:0030205)3.27740837
26purine ribonucleotide transport (GO:0015868)3.24302475
27adenine nucleotide transport (GO:0051503)3.24119132
28indolalkylamine metabolic process (GO:0006586)3.22739519
29C4-dicarboxylate transport (GO:0015740)3.21806463
30positive regulation of cellular amide metabolic process (GO:0034250)3.21328599
31dicarboxylic acid biosynthetic process (GO:0043650)3.21044440
32L-fucose catabolic process (GO:0042355)3.19523337
33fucose catabolic process (GO:0019317)3.19523337
34L-fucose metabolic process (GO:0042354)3.19523337
35alpha-linolenic acid metabolic process (GO:0036109)3.19456546
36regulation of astrocyte differentiation (GO:0048710)3.17181701
37neural tube formation (GO:0001841)3.15698127
38somatic stem cell division (GO:0048103)3.15547157
39chondroitin sulfate catabolic process (GO:0030207)3.13421010
40somite development (GO:0061053)3.13181796
41gap junction assembly (GO:0016264)3.10476788
42renal tubule morphogenesis (GO:0061333)3.09360602
43axoneme assembly (GO:0035082)3.09031263
44homocysteine metabolic process (GO:0050667)3.07720472
45reverse cholesterol transport (GO:0043691)3.07558358
46cilium or flagellum-dependent cell motility (GO:0001539)3.06665613
47mesenchyme morphogenesis (GO:0072132)3.02030366
48interkinetic nuclear migration (GO:0022027)3.01568965
49purine nucleotide transport (GO:0015865)2.99512872
50cellular response to ATP (GO:0071318)2.98437696
51positive regulation of fatty acid beta-oxidation (GO:0032000)2.98194016
52retinal rod cell development (GO:0046548)2.98074002
53epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.98063470
54mesenchymal cell proliferation (GO:0010463)2.94701607
55* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.94138552
56cell proliferation involved in metanephros development (GO:0072203)2.93971326
57tryptophan metabolic process (GO:0006568)2.93500065
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.91146429
59paraxial mesoderm development (GO:0048339)2.90651154
60kynurenine metabolic process (GO:0070189)2.90030504
61protein targeting to Golgi (GO:0000042)2.88147535
62alanine transport (GO:0032328)2.88127224
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85839200
64limb development (GO:0060173)2.84856416
65appendage development (GO:0048736)2.84856416
66gamma-aminobutyric acid transport (GO:0015812)2.83688258
67protein localization to Golgi apparatus (GO:0034067)2.81849027
68cellular response to sterol (GO:0036315)2.81818089
69regulation of mesoderm development (GO:2000380)2.80883014
70negative regulation of stress fiber assembly (GO:0051497)2.79607453
71G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79316389
72pericardium development (GO:0060039)2.79286305
73male sex determination (GO:0030238)2.79084046
74cell communication by electrical coupling (GO:0010644)2.78379868
75cellular ketone body metabolic process (GO:0046950)2.77548356
76protein-lipid complex remodeling (GO:0034368)2.77348413
77macromolecular complex remodeling (GO:0034367)2.77348413
78plasma lipoprotein particle remodeling (GO:0034369)2.77348413
79negative regulation of glial cell differentiation (GO:0045686)2.77272198
80detection of light stimulus involved in visual perception (GO:0050908)2.76170559
81detection of light stimulus involved in sensory perception (GO:0050962)2.76170559
82high-density lipoprotein particle remodeling (GO:0034375)2.74754145
83response to pheromone (GO:0019236)2.74502548
84lymphangiogenesis (GO:0001946)2.74348122
85positive regulation of fatty acid oxidation (GO:0046321)2.72694376
86very-low-density lipoprotein particle assembly (GO:0034379)2.72044120
87retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69972998
88signal peptide processing (GO:0006465)2.69403670
89* regulation of non-canonical Wnt signaling pathway (GO:2000050)2.69091878
90embryonic camera-type eye morphogenesis (GO:0048596)2.68670845
91neuroblast proliferation (GO:0007405)2.68471051
92cell proliferation involved in kidney development (GO:0072111)2.67213299
93* epithelial cilium movement (GO:0003351)2.66127969
94plasma lipoprotein particle organization (GO:0071827)2.66007021
95sulfation (GO:0051923)2.62901102
96positive regulation of glycogen biosynthetic process (GO:0045725)2.62415293
97* cilium movement (GO:0003341)2.62040139
98regulation of hippo signaling (GO:0035330)2.61110108
99linoleic acid metabolic process (GO:0043651)2.59987142
100histone H3-K4 trimethylation (GO:0080182)2.59900664
101neurotransmitter-gated ion channel clustering (GO:0072578)2.58936083
102plasma lipoprotein particle assembly (GO:0034377)2.58217220
103negative regulation of smoothened signaling pathway (GO:0045879)2.57306338
104sodium ion export (GO:0071436)2.54259623
105cilium organization (GO:0044782)2.54155593
106head development (GO:0060322)2.54067714
107positive regulation of triglyceride biosynthetic process (GO:0010867)2.53104464
108tooth mineralization (GO:0034505)2.52258702
109mesenchymal-epithelial cell signaling (GO:0060638)2.51859166
110ketone body metabolic process (GO:1902224)2.50587251
111cellular modified amino acid catabolic process (GO:0042219)2.50463965
112glomerular filtration (GO:0003094)2.49930279
113cornea development in camera-type eye (GO:0061303)2.47683330
114rRNA catabolic process (GO:0016075)2.47168920
115thyroid hormone metabolic process (GO:0042403)2.46609542
116embryonic skeletal joint morphogenesis (GO:0060272)2.45915133
117inner ear receptor stereocilium organization (GO:0060122)2.45904763
118left/right axis specification (GO:0070986)2.44884605
119craniofacial suture morphogenesis (GO:0097094)2.44676622
120cellular glucuronidation (GO:0052695)2.44370739
121piRNA metabolic process (GO:0034587)2.44016788
122hippo signaling (GO:0035329)2.43156084
123prostate gland growth (GO:0060736)2.42678053
124myelination in peripheral nervous system (GO:0022011)2.42407729
125peripheral nervous system axon ensheathment (GO:0032292)2.42407729
126short-chain fatty acid metabolic process (GO:0046459)2.42251353
127cilium assembly (GO:0042384)2.41640023
128embryonic epithelial tube formation (GO:0001838)2.41458370
129DNA deamination (GO:0045006)2.41356260
130axon extension involved in axon guidance (GO:0048846)2.41276887
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.41276887
132hematopoietic stem cell proliferation (GO:0071425)2.41273513
133cranial suture morphogenesis (GO:0060363)2.40943342
134protein K11-linked deubiquitination (GO:0035871)2.40241513
135protein-lipid complex subunit organization (GO:0071825)2.39139357
136nonmotile primary cilium assembly (GO:0035058)2.38946139
137dermatan sulfate biosynthetic process (GO:0030208)2.38711668
138biotin metabolic process (GO:0006768)2.38261913
139neuronal action potential (GO:0019228)2.37950841
140* cilium morphogenesis (GO:0060271)2.37889718
141fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37494510
142positive regulation of glycogen metabolic process (GO:0070875)2.37483801
143glutamate metabolic process (GO:0006536)2.36346502
144positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.36216958
145regulation of hexokinase activity (GO:1903299)2.35677545
146regulation of glucokinase activity (GO:0033131)2.35677545
147smooth muscle tissue development (GO:0048745)2.35658351
148endocardial cushion morphogenesis (GO:0003203)2.35631541
149regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35630569
150regulation of establishment or maintenance of cell polarity (GO:0032878)2.35433425
151positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.35388920
152negative regulation of neurotransmitter transport (GO:0051589)2.34849214
153* kidney morphogenesis (GO:0060993)2.34522053
154negative regulation of osteoblast proliferation (GO:0033689)2.34519345
155regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.34252163
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33640887
157L-phenylalanine catabolic process (GO:0006559)2.33640887
158photoreceptor cell differentiation (GO:0046530)2.32928312
159eye photoreceptor cell differentiation (GO:0001754)2.32928312
160regulation of establishment of cell polarity (GO:2000114)2.32841919
161photoreceptor cell development (GO:0042461)2.32832260
162retinal cone cell development (GO:0046549)2.32228195
163forebrain morphogenesis (GO:0048853)2.29207489
164blood vessel maturation (GO:0001955)2.29204658
165embryonic retina morphogenesis in camera-type eye (GO:0060059)2.28026620
166smoothened signaling pathway (GO:0007224)2.27967953
167cardiovascular system development (GO:0072358)2.27838352
168smooth muscle contraction (GO:0006939)2.27833500
169cGMP-mediated signaling (GO:0019934)2.27371491
170* photoreceptor cell maintenance (GO:0045494)2.26639481
171regulation of sister chromatid cohesion (GO:0007063)2.26606437
172phasic smooth muscle contraction (GO:0014821)2.26585066
173potassium ion homeostasis (GO:0055075)2.26302142
174activated T cell proliferation (GO:0050798)2.25894887
175negative regulation of mast cell activation (GO:0033004)2.25813989
176positive regulation of extracellular matrix organization (GO:1903055)2.25658803
177carnitine metabolic process (GO:0009437)2.25160336
178ethanol oxidation (GO:0006069)2.24710687
179behavioral response to ethanol (GO:0048149)2.24624178
180regulation of fatty acid beta-oxidation (GO:0031998)2.24346680
181regulation of cilium movement (GO:0003352)2.23238542
182dentate gyrus development (GO:0021542)2.22985590
183cellular biogenic amine catabolic process (GO:0042402)2.21289881
184amine catabolic process (GO:0009310)2.21289881
185regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.20149544
186cAMP catabolic process (GO:0006198)2.19760821
187detection of mechanical stimulus involved in sensory perception (GO:0050974)2.19705486
188epithelial tube formation (GO:0072175)2.19503901
189indole-containing compound metabolic process (GO:0042430)2.18514417
190negative regulation of axon guidance (GO:1902668)2.16962812
191regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.16227240
192positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.15981474
193negative regulation of systemic arterial blood pressure (GO:0003085)2.15281732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.64227429
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96242462
3GBX2_23144817_ChIP-Seq_PC3_Human2.94413849
4ZNF274_21170338_ChIP-Seq_K562_Hela2.93142767
5VDR_22108803_ChIP-Seq_LS180_Human2.80011427
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56338424
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.27513996
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.23656384
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.08252744
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05724884
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00771228
12AR_21572438_ChIP-Seq_LNCaP_Human2.00414273
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97267099
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95570410
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93693594
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93479619
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86503382
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86179091
19TAF15_26573619_Chip-Seq_HEK293_Human1.84127690
20IGF1R_20145208_ChIP-Seq_DFB_Human1.83006561
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82496085
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81614142
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80693842
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80242101
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.78881325
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73498916
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.72844569
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71577853
29TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.71011876
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70750501
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70210322
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.70099780
33ER_23166858_ChIP-Seq_MCF-7_Human1.68576019
34P300_19829295_ChIP-Seq_ESCs_Human1.67328301
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67202304
36FUS_26573619_Chip-Seq_HEK293_Human1.65972976
37TP53_16413492_ChIP-PET_HCT116_Human1.62691532
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61772529
39* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61528164
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61159835
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61159835
42BCAT_22108803_ChIP-Seq_LS180_Human1.59823030
43EZH2_22144423_ChIP-Seq_EOC_Human1.59783929
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58776940
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57246806
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.56700957
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.56237165
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56085520
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50980542
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49733647
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.47523567
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45229431
53SMAD4_21799915_ChIP-Seq_A2780_Human1.44398719
54EWS_26573619_Chip-Seq_HEK293_Human1.44112535
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43261568
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.41342149
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40635234
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39287298
59* RXR_22158963_ChIP-Seq_LIVER_Mouse1.39199792
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38366801
61STAT3_23295773_ChIP-Seq_U87_Human1.38126432
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37643460
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37643460
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36696742
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36105195
66CBP_20019798_ChIP-Seq_JUKART_Human1.35368370
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35368370
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34303447
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.33930387
70* RXR_22108803_ChIP-Seq_LS180_Human1.33077722
71* AR_25329375_ChIP-Seq_VCAP_Human1.32049323
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31380253
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.30922453
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30772751
75* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30545028
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30472007
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29617225
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29405674
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28119267
80* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27573589
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26186677
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25696841
83CJUN_26792858_Chip-Seq_BT549_Human1.24848258
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24542734
85RUNX2_22187159_ChIP-Seq_PCA_Human1.23554264
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.22966272
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22866732
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22199439
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21887125
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.21219186
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.20456705
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.20388382
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19923789
94CDX2_22108803_ChIP-Seq_LS180_Human1.19810608
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.19139458
96AR_19668381_ChIP-Seq_PC3_Human1.19015389
97SOX2_19829295_ChIP-Seq_ESCs_Human1.18681482
98NANOG_19829295_ChIP-Seq_ESCs_Human1.18681482
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18268086
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17871472
101DROSHA_22980978_ChIP-Seq_HELA_Human1.17682379
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.16752869
103TP53_18474530_ChIP-ChIP_U2OS_Human1.16404634
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16109976
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15861436
106* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13898749
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.13581489
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12995966
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12903814
110* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12356789
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12284603
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11857474
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10717272
114TCF4_23295773_ChIP-Seq_U87_Human1.10082321
115P53_22387025_ChIP-Seq_ESCs_Mouse1.09655831
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09368537
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09161775
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08476694
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.08430097
120* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07598228
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07161933
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.06915541
123TRIM28_21343339_ChIP-Seq_HEK293_Human1.06475028
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05575068
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.05304168
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04848384
127FOXA2_19822575_ChIP-Seq_HepG2_Human1.03043736
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02750261
129KDM2B_26808549_Chip-Seq_REH_Human1.02229404
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00957414
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00368731
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00368731
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.00163584
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00077124
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99873063
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.99696414
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98847751
138RNF2_27304074_Chip-Seq_NSC_Mouse0.98580776
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98313185
140AHR_22903824_ChIP-Seq_MCF-7_Human0.98208668
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97888640
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.96722883
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96232479
144TP53_22573176_ChIP-Seq_HFKS_Human0.96189413
145TCF4_22108803_ChIP-Seq_LS180_Human0.95861707
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95861578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009384_cardiac_valve_regurgitation3.75707132
2MP0002139_abnormal_hepatobiliary_system3.23538137
3MP0005646_abnormal_pituitary_gland3.06623213
4MP0002837_dystrophic_cardiac_calcinosis2.95990792
5MP0002249_abnormal_larynx_morphology2.85582770
6MP0008877_abnormal_DNA_methylation2.81224968
7MP0003690_abnormal_glial_cell2.72437209
8MP0010368_abnormal_lymphatic_system2.68983251
9MP0003787_abnormal_imprinting2.61607944
10MP0000569_abnormal_digit_pigmentation2.58636749
11MP0003878_abnormal_ear_physiology2.44160123
12MP0005377_hearing/vestibular/ear_phenot2.44160123
13MP0002928_abnormal_bile_duct2.37805530
14MP0001879_abnormal_lymphatic_vessel2.37319002
15MP0003195_calcinosis2.20813578
16MP0003942_abnormal_urinary_system2.16335946
17MP0003646_muscle_fatigue2.14895084
18MP0009697_abnormal_copulation2.13305939
19MP0000566_synostosis2.13271649
20MP0005360_urolithiasis2.09188241
21MP0000534_abnormal_ureter_morphology2.04792448
22MP0005174_abnormal_tail_pigmentation2.04529147
23MP0009250_abnormal_appendicular_skeleto2.03138153
24MP0001986_abnormal_taste_sensitivity2.00013008
25MP0000383_abnormal_hair_follicle1.99993014
26MP0000049_abnormal_middle_ear1.98449015
27MP0002938_white_spotting1.95471371
28MP0004134_abnormal_chest_morphology1.90723428
29MP0009780_abnormal_chondrocyte_physiolo1.82074781
30MP0000427_abnormal_hair_cycle1.81540137
31MP0003136_yellow_coat_color1.81165841
32MP0003283_abnormal_digestive_organ1.79455115
33* MP0003279_aneurysm1.79072935
34MP0001984_abnormal_olfaction1.79055209
35MP0004885_abnormal_endolymph1.77098032
36MP0002254_reproductive_system_inflammat1.77026727
37MP0003385_abnormal_body_wall1.75422701
38MP0003937_abnormal_limbs/digits/tail_de1.72630429
39MP0002138_abnormal_hepatobiliary_system1.67410319
40MP0005085_abnormal_gallbladder_physiolo1.67199378
41MP0003122_maternal_imprinting1.66953543
42MP0000428_abnormal_craniofacial_morphol1.64958633
43MP0001968_abnormal_touch/_nociception1.63497504
44MP0004145_abnormal_muscle_electrophysio1.63343950
45MP0006072_abnormal_retinal_apoptosis1.61920183
46MP0004142_abnormal_muscle_tone1.60699003
47MP0005503_abnormal_tendon_morphology1.59349200
48MP0001486_abnormal_startle_reflex1.58388741
49MP0005365_abnormal_bile_salt1.56943065
50MP0009053_abnormal_anal_canal1.56557690
51MP0005551_abnormal_eye_electrophysiolog1.55658062
52MP0001293_anophthalmia1.52747329
53MP0003252_abnormal_bile_duct1.51592791
54MP0001501_abnormal_sleep_pattern1.49076218
55MP0000537_abnormal_urethra_morphology1.48229370
56MP0000013_abnormal_adipose_tissue1.46480630
57MP0002233_abnormal_nose_morphology1.46022251
58MP0005623_abnormal_meninges_morphology1.43195466
59MP0001485_abnormal_pinna_reflex1.43132829
60MP0001502_abnormal_circadian_rhythm1.43039938
61MP0002876_abnormal_thyroid_physiology1.38297266
62MP0003121_genomic_imprinting1.37184770
63MP0003868_abnormal_feces_composition1.36517723
64MP0004130_abnormal_muscle_cell1.35516191
65MP0004084_abnormal_cardiac_muscle1.35443573
66MP0000230_abnormal_systemic_arterial1.34928611
67MP0005084_abnormal_gallbladder_morpholo1.34605963
68MP0004272_abnormal_basement_membrane1.33986471
69MP0002932_abnormal_joint_morphology1.33218196
70MP0003045_fibrosis1.31888929
71MP0005508_abnormal_skeleton_morphology1.31408920
72* MP0002116_abnormal_craniofacial_bone1.29708500
73MP0000462_abnormal_digestive_system1.28714598
74MP0003950_abnormal_plasma_membrane1.28637047
75MP0003806_abnormal_nucleotide_metabolis1.28403786
76MP0010329_abnormal_lipoprotein_level1.27272681
77MP0008775_abnormal_heart_ventricle1.27052967
78MP0003705_abnormal_hypodermis_morpholog1.25962322
79MP0008872_abnormal_physiological_respon1.24766631
80MP0004215_abnormal_myocardial_fiber1.21810322
81MP0006054_spinal_hemorrhage1.20767399
82MP0004133_heterotaxia1.20618808
83MP0002234_abnormal_pharynx_morphology1.19181072
84MP0001915_intracranial_hemorrhage1.18794100
85MP0010030_abnormal_orbit_morphology1.18157444
86MP0001958_emphysema1.18116285
87MP0002127_abnormal_cardiovascular_syste1.17875519
88MP0003935_abnormal_craniofacial_develop1.17742010
89MP0010386_abnormal_urinary_bladder1.17179973
90MP0004858_abnormal_nervous_system1.16868624
91MP0000372_irregular_coat_pigmentation1.15834291
92MP0001299_abnormal_eye_distance/1.15544371
93MP0010678_abnormal_skin_adnexa1.13760931
94MP0005248_abnormal_Harderian_gland1.12604618
95MP0002089_abnormal_postnatal_growth/wei1.12546731
96MP0002108_abnormal_muscle_morphology1.11717825
97MP0005389_reproductive_system_phenotype1.11376088
98MP0005167_abnormal_blood-brain_barrier1.11197980
99MP0003137_abnormal_impulse_conducting1.11067880
100MP0006292_abnormal_olfactory_placode1.11014039
101MP0009703_decreased_birth_body1.10318646
102MP0005647_abnormal_sex_gland1.09300992
103MP0005171_absent_coat_pigmentation1.08984144
104* MP0000432_abnormal_head_morphology1.08021575
105MP0002638_abnormal_pupillary_reflex1.07522571
106MP0005332_abnormal_amino_acid1.07209498
107MP0002109_abnormal_limb_morphology1.06926163
108MP0003172_abnormal_lysosome_physiology1.06668320
109* MP0001270_distended_abdomen1.06502916
110MP0003755_abnormal_palate_morphology1.06397129
111MP0002282_abnormal_trachea_morphology1.04464346
112MP0008961_abnormal_basal_metabolism1.03600147
113MP0005645_abnormal_hypothalamus_physiol1.02474799
114MP0000767_abnormal_smooth_muscle1.02308342
115MP0006138_congestive_heart_failure0.99709388
116MP0000163_abnormal_cartilage_morphology0.99644446
117MP0009046_muscle_twitch0.98014316
118MP0005257_abnormal_intraocular_pressure0.97687385
119MP0002160_abnormal_reproductive_system0.96770872
120MP0000538_abnormal_urinary_bladder0.95541993
121MP0002697_abnormal_eye_size0.95425509
122MP0000015_abnormal_ear_pigmentation0.94808801
123MP0002896_abnormal_bone_mineralization0.94657897
124MP0003890_abnormal_embryonic-extraembry0.93093901
125MP0005275_abnormal_skin_tensile0.92081900
126MP0005195_abnormal_posterior_eye0.90292475
127MP0000631_abnormal_neuroendocrine_gland0.90071617
128MP0009745_abnormal_behavioral_response0.87580416
129MP0008438_abnormal_cutaneous_collagen0.87435713
130MP0002115_abnormal_skeleton_extremities0.87341696
131MP0004147_increased_porphyrin_level0.87092149
132MP0002090_abnormal_vision0.86967033
133MP0008875_abnormal_xenobiotic_pharmacok0.86044843
134MP0002095_abnormal_skin_pigmentation0.85976329
135MP0002102_abnormal_ear_morphology0.85104930
136MP0002736_abnormal_nociception_after0.84701174
137MP0003011_delayed_dark_adaptation0.84070767
138MP0000026_abnormal_inner_ear0.82989933
139MP0005595_abnormal_vascular_smooth0.82325960
140MP0004043_abnormal_pH_regulation0.82297376
141MP0002933_joint_inflammation0.82294278
142MP0004233_abnormal_muscle_weight0.81558603
143MP0002557_abnormal_social/conspecific_i0.81359408
144MP0005670_abnormal_white_adipose0.81062487
145MP0004484_altered_response_of0.80973567
146MP0001286_abnormal_eye_development0.80263548
147MP0000639_abnormal_adrenal_gland0.80141024
148MP0000371_diluted_coat_color0.78829655
149MP0002168_other_aberrant_phenotype0.78634173
150MP0001849_ear_inflammation0.78617803
151MP0002009_preneoplasia0.78534970
152MP0005253_abnormal_eye_physiology0.78217390
153MP0005386_behavior/neurological_phenoty0.78199846
154MP0004924_abnormal_behavior0.78199846
155MP0002272_abnormal_nervous_system0.77862258
156MP0002128_abnormal_blood_circulation0.77746499
157MP0001346_abnormal_lacrimal_gland0.77730408
158MP0001324_abnormal_eye_pigmentation0.77648661
159MP0002177_abnormal_outer_ear0.77381200
160MP0001756_abnormal_urination0.77175089
161MP0005408_hypopigmentation0.73251214
162MP0005391_vision/eye_phenotype0.70641626

Predicted human phenotypes

RankGene SetZ-score
1* Pancreatic cysts (HP:0001737)4.39778397
2Aplasia involving bones of the extremities (HP:0009825)4.34956976
3Aplasia involving bones of the upper limbs (HP:0009823)4.34956976
4Aplasia of the phalanges of the hand (HP:0009802)4.34956976
5Nephronophthisis (HP:0000090)4.32271808
6Abnormality of midbrain morphology (HP:0002418)4.18210335
7Molar tooth sign on MRI (HP:0002419)4.18210335
8Tubulointerstitial nephritis (HP:0001970)3.99020726
9True hermaphroditism (HP:0010459)3.96608549
10* Abnormality of the renal cortex (HP:0011035)3.95586593
11* Pancreatic fibrosis (HP:0100732)3.82943085
12Hyperventilation (HP:0002883)3.78154018
13* Abnormality of the renal medulla (HP:0100957)3.73481046
14Congenital stationary night blindness (HP:0007642)3.44165323
15Renal cortical cysts (HP:0000803)3.28518435
16Chronic hepatic failure (HP:0100626)3.26292019
17Short hallux (HP:0010109)2.98852225
18Keratoconus (HP:0000563)2.98680686
19Increased corneal curvature (HP:0100692)2.98680686
20Congenital, generalized hypertrichosis (HP:0004540)2.97309860
21Midline defect of the nose (HP:0004122)2.94434334
22Stomach cancer (HP:0012126)2.89143076
23Type II lissencephaly (HP:0007260)2.87491275
24Synostosis involving the elbow (HP:0003938)2.87361708
25Humeroradial synostosis (HP:0003041)2.87361708
26Genetic anticipation (HP:0003743)2.84468552
27Abnormality of the middle phalanges of the toes (HP:0010183)2.77997753
28Broad metatarsal (HP:0001783)2.72531660
29Medial flaring of the eyebrow (HP:0010747)2.72372928
30Abolished electroretinogram (ERG) (HP:0000550)2.70396966
31Fair hair (HP:0002286)2.70017952
32Absent/shortened dynein arms (HP:0200106)2.69820435
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.69820435
34Intrahepatic cholestasis (HP:0001406)2.63294594
35Aplasia/Hypoplasia of the hallux (HP:0008362)2.62890416
36Hyperglycinemia (HP:0002154)2.61144787
37Hypoglycemic seizures (HP:0002173)2.60079943
38* Cystic liver disease (HP:0006706)2.55748549
39Long nose (HP:0003189)2.54294233
40Hypoplastic left heart (HP:0004383)2.53433277
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50611979
42Short 4th metacarpal (HP:0010044)2.50611979
43Attenuation of retinal blood vessels (HP:0007843)2.50356317
44Chorioretinal atrophy (HP:0000533)2.48891552
45Protruding tongue (HP:0010808)2.47029278
46Hypoplastic ischia (HP:0003175)2.41423624
47Gaze-evoked nystagmus (HP:0000640)2.39268097
48Abnormal rod and cone electroretinograms (HP:0008323)2.37528026
49* Congenital hepatic fibrosis (HP:0002612)2.33323150
50Bulbous nose (HP:0000414)2.32822136
51Septo-optic dysplasia (HP:0100842)2.32575958
52Pseudobulbar signs (HP:0002200)2.31613049
53Decreased circulating renin level (HP:0003351)2.31468361
54Mixed hearing impairment (HP:0000410)2.30781467
55* Abnormal drinking behavior (HP:0030082)2.30363938
56* Polydipsia (HP:0001959)2.30363938
57Neonatal short-limb short stature (HP:0008921)2.30136472
58Abnormality of the nasal septum (HP:0000419)2.26028203
59Diplopia (HP:0000651)2.24295625
60Abnormality of binocular vision (HP:0011514)2.24295625
61Selective tooth agenesis (HP:0001592)2.24058123
62Abnormal respiratory epithelium morphology (HP:0012253)2.23619102
63Abnormal respiratory motile cilium morphology (HP:0005938)2.23619102
64Abnormality of the ischium (HP:0003174)2.23328319
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.22387743
66Sclerocornea (HP:0000647)2.22305606
67Abnormality of glycine metabolism (HP:0010895)2.21847662
68Abnormality of serine family amino acid metabolism (HP:0010894)2.21847662
69Generalized hypopigmentation of hair (HP:0011358)2.19859261
70Hyperglycinuria (HP:0003108)2.19757329
71Hypoalphalipoproteinemia (HP:0003233)2.17671068
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16909291
73Hematochezia (HP:0002573)2.15323837
74Cutaneous syndactyly (HP:0012725)2.14947640
75Broad toe (HP:0001837)2.14248536
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.13620843
77Shallow orbits (HP:0000586)2.11371579
78Cerebellar dysplasia (HP:0007033)2.10216625
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09161924
80Morphological abnormality of the middle ear (HP:0008609)2.09039080
81Hyperlipoproteinemia (HP:0010980)2.08847412
82Abnormal ciliary motility (HP:0012262)2.07024184
83Broad long bones (HP:0005622)2.06500227
84Hemiplegia (HP:0002301)2.05900752
85Furrowed tongue (HP:0000221)2.05889384
86Postaxial foot polydactyly (HP:0001830)2.04826187
87Hypoplastic iliac wings (HP:0002866)2.04492163
88Large for gestational age (HP:0001520)2.04339260
89Trigonocephaly (HP:0000243)2.03411713
90Volvulus (HP:0002580)1.99835291
91Anencephaly (HP:0002323)1.99730190
92* Tubular atrophy (HP:0000092)1.99489144
93Clumsiness (HP:0002312)1.99007562
94Abnormality of the phalanges of the 5th finger (HP:0004213)1.97983209
95Abnormality of the pons (HP:0007361)1.96636731
96Absent speech (HP:0001344)1.96397342
97Biconcave vertebral bodies (HP:0004586)1.95474964
98Broad finger (HP:0001500)1.95017056
99Progressive cerebellar ataxia (HP:0002073)1.94977708
100Hypoplasia of the pons (HP:0012110)1.94814715
101Skull defect (HP:0001362)1.94718415
102Broad hallux (HP:0010055)1.94253560
103Optic nerve hypoplasia (HP:0000609)1.92292944
104Small hand (HP:0200055)1.90942605
105Short middle phalanx of the 5th finger (HP:0004220)1.89934043
106Intestinal atresia (HP:0011100)1.89670158
107Turricephaly (HP:0000262)1.89507573
108Aplasia/Hypoplasia of the fibula (HP:0006492)1.88651864
109Widely spaced teeth (HP:0000687)1.88645247
110Anophthalmia (HP:0000528)1.88154142
111Male pseudohermaphroditism (HP:0000037)1.86406866
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86299940
113Large earlobe (HP:0009748)1.86010680
114* Bile duct proliferation (HP:0001408)1.85523685
115* Abnormal biliary tract physiology (HP:0012439)1.85523685
116Blepharitis (HP:0000498)1.84833926
117Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84695250
118Broad thumb (HP:0011304)1.84619176
119Coronal craniosynostosis (HP:0004440)1.84524801
120Confusion (HP:0001289)1.84008532
121Short foot (HP:0001773)1.83973962
122Abnormality of the diencephalon (HP:0010662)1.82818290
123Cutaneous finger syndactyly (HP:0010554)1.82749330
124Limited elbow extension (HP:0001377)1.82518747
125Thyroiditis (HP:0100646)1.82087957
126Broad phalanges of the hand (HP:0009768)1.81925928
127Abnormal number of incisors (HP:0011064)1.81305456
128Truncal obesity (HP:0001956)1.80692491
129Absent septum pellucidum (HP:0001331)1.78704759
130Hyperinsulinemic hypoglycemia (HP:0000825)1.78432955
131* Polyuria (HP:0000103)1.78248465
132Tachypnea (HP:0002789)1.78062751
133Abnormality of the parietal bone (HP:0002696)1.78031141
134Bronchomalacia (HP:0002780)1.77941632
135Broad phalanx (HP:0006009)1.77328439
136Hemiparesis (HP:0001269)1.77322431
137Congenital sensorineural hearing impairment (HP:0008527)1.76420266
138Febrile seizures (HP:0002373)1.76193117
139Abnormal pancreas size (HP:0012094)1.76170413
140Mesomelia (HP:0003027)1.75942959
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.75521954
142Abnormality of the dental pulp (HP:0006479)1.74916273
143Metabolic alkalosis (HP:0200114)1.74883605
144Hypoplastic heart (HP:0001961)1.74604226
145Genital tract atresia (HP:0001827)1.74460758
146Abnormality of the 4th metacarpal (HP:0010012)1.74140527
147Narrow nasal bridge (HP:0000446)1.73729743
148Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73692305
149Congenital primary aphakia (HP:0007707)1.73632679
150Postaxial hand polydactyly (HP:0001162)1.73593393
151Absent toe (HP:0010760)1.73587364
152* Tubulointerstitial abnormality (HP:0001969)1.73399400
153Prolonged QT interval (HP:0001657)1.73299351
154Inability to walk (HP:0002540)1.73206998
155Depressed nasal tip (HP:0000437)1.72812880
156Short middle phalanx of finger (HP:0005819)1.72754290
157Back pain (HP:0003418)1.72366766
158Cranial hyperostosis (HP:0004437)1.72313552
159Vaginal atresia (HP:0000148)1.70703477
160Abnormality of secondary sexual hair (HP:0009888)1.70117337
161Abnormality of the axillary hair (HP:0100134)1.70117337
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69914538
163Calf muscle hypertrophy (HP:0008981)1.69788964
164Stage 5 chronic kidney disease (HP:0003774)1.69578687
165Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.69362863
166Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68797775
167Deep venous thrombosis (HP:0002625)1.68131386
168Portal hypertension (HP:0001409)1.66728103
169Abnormality of the pubic bones (HP:0003172)1.66383226
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66292058
171Gait imbalance (HP:0002141)1.66011870
172Hypoplastic labia majora (HP:0000059)1.65957935
173Short humerus (HP:0005792)1.65815671
174Bell-shaped thorax (HP:0001591)1.64768834
175Muscle hypertrophy of the lower extremities (HP:0008968)1.64146090
176Cervical subluxation (HP:0003308)1.63969367
177Symptomatic seizures (HP:0011145)1.63086063
178Nephrogenic diabetes insipidus (HP:0009806)1.62335589
179Decreased central vision (HP:0007663)1.62236753
180Abnormality of the fingertips (HP:0001211)1.61746895
181Fibular hypoplasia (HP:0003038)1.61654000
182Abnormality of the middle phalanges of the hand (HP:0009833)1.61485388
183Bony spicule pigmentary retinopathy (HP:0007737)1.61478089
184Occipital encephalocele (HP:0002085)1.61242351
185Ketoacidosis (HP:0001993)1.60912152
186Homocystinuria (HP:0002156)1.60577572
187Abnormality of homocysteine metabolism (HP:0010919)1.60577572
188Prolonged partial thromboplastin time (HP:0003645)1.60511917
189Xanthomatosis (HP:0000991)1.60389584
1902-3 toe syndactyly (HP:0004691)1.59448218
191Vitreoretinal degeneration (HP:0000655)1.58214477
192Arthropathy (HP:0003040)1.57673305
193Abnormality of the wing of the ilium (HP:0011867)1.57093860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.25338734
2SIK13.79885484
3CAMK1D3.32350549
4INSRR3.02833342
5CAMK1G3.00431289
6LATS12.85440996
7WNK42.79274739
8MUSK2.75383031
9ACVR1B2.49009999
10ADRBK22.46376088
11CDK82.31266548
12PINK12.27207372
13TAOK32.19768002
14STK392.13372099
15GRK12.12745703
16FGFR21.87334791
17NTRK21.82365497
18DDR21.77263933
19STK38L1.68876630
20PHKG21.68772732
21PHKG11.68772732
22PIK3CA1.68609503
23TNIK1.67475178
24ZAK1.64191833
25MAP4K21.62178669
26MAP3K41.53318670
27TIE11.52782142
28STK31.52121551
29MAPK151.51235763
30SGK21.49597662
31EPHB21.48136238
32TRIB31.45668610
33BRD41.39205049
34PDGFRA1.38492339
35MAP3K71.38380482
36PRKAA21.36421196
37CDK121.36133434
38WNK31.35878973
39PTK61.32702672
40OXSR11.32294758
41TRPM71.28967492
42RIPK11.28961536
43NUAK11.28254504
44NLK1.27288928
45PIK3CG1.25135359
46TXK1.24831465
47FGFR11.23977364
48LMTK21.23154774
49TEC1.22345469
50BRSK21.17329321
51SGK31.13639794
52FLT31.12604058
53TGFBR11.08403906
54TLK11.08386277
55DMPK1.07263495
56DAPK21.07172542
57TTK1.07121203
58STK381.01766313
59BMPR1B1.01713683
60KIT0.99418854
61CDC42BPA0.95181020
62PRKAA10.94212763
63PTK2B0.94092119
64CDK30.92378026
65DYRK1A0.91984019
66JAK10.91900839
67CDK90.90678867
68BMX0.90207125
69WNK10.89727856
70SGK4940.89634914
71SGK2230.89634914
72ERBB40.88171472
73PLK20.86436580
74FGFR40.85379137
75MKNK20.84853862
76MELK0.84164848
77NEK90.82861887
78ERBB20.82493592
79LATS20.81069325
80ITK0.79873968
81CDK60.78936211
82IGF1R0.78854877
83OBSCN0.78738586
84YES10.78701698
85CASK0.78452560
86MAPK70.78044423
87STK240.77855988
88CAMKK20.76931092
89FGFR30.75659502
90PKN20.75035343
91EPHA30.74296878
92PRKCQ0.72942980
93MAPKAPK30.72765952
94TAOK20.70764349
95CAMK10.70499821
96TNK20.67733870
97CSNK1A1L0.67180912
98IKBKB0.66053661
99MAP3K60.65735479
100CAMK40.65630088
101MAPK120.65497784
102MYLK0.65424873
103AKT20.65396296
104EIF2AK20.64900474
105MTOR0.63297510
106PDGFRB0.61648376
107STK110.60441179
108STK100.60352179
109NEK10.60109355
110RPS6KA60.57804001
111PAK30.57228473
112CHUK0.56407812
113ROCK10.55320626
114CSNK1D0.54494131
115MAP2K40.54080745
116FER0.50461746
117JAK30.50411235
118NTRK30.50392433
119MARK20.50004072
120GRK70.49950413
121IRAK10.49929489
122MAPK10.49706780
123MAPK110.49456253
124TGFBR20.49347966
125BCKDK0.48942479
126PLK40.48262129
127MAP2K60.47732753
128MAPK100.47281617
129PRKCG0.47125296
130PBK0.46197070
131AKT30.45496219
132CSNK1G10.44799230
133MAP3K130.44281551
134MAPK140.42676970
135IKBKE0.42613274
136MAPK130.42322777
137CSNK1G20.41929793
138PRKCE0.41635084
139BTK0.41221873
140ADRBK10.41055490
141CDC70.41007333
142CCNB10.40951217
143PTK20.40606272
144MKNK10.39615264
145NEK60.39466126
146SRC0.38051065
147AKT10.37925270
148RPS6KB10.37119047
149PRKG10.36996753
150ABL10.36782982
151PNCK0.36713151
152SGK10.36523462
153PRKACA0.35613847
154MAP3K140.34972696
155CAMK2A0.34497573
156PRKD20.32350488

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009106.75302482
2Fatty acid biosynthesis_Homo sapiens_hsa000613.46547242
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92732920
4Linoleic acid metabolism_Homo sapiens_hsa005912.66971135
5Fatty acid degradation_Homo sapiens_hsa000712.56393966
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55047699
7Phototransduction_Homo sapiens_hsa047442.36790424
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.30770164
9Fatty acid metabolism_Homo sapiens_hsa012122.26291560
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.20147949
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07431133
12Bile secretion_Homo sapiens_hsa049762.04439844
13Ether lipid metabolism_Homo sapiens_hsa005651.88120555
14Arginine biosynthesis_Homo sapiens_hsa002201.75634538
15PPAR signaling pathway_Homo sapiens_hsa033201.74968014
16Lysine degradation_Homo sapiens_hsa003101.72461195
17Propanoate metabolism_Homo sapiens_hsa006401.72216190
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64124273
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61577179
20Basal cell carcinoma_Homo sapiens_hsa052171.61317981
21Peroxisome_Homo sapiens_hsa041461.60592519
22One carbon pool by folate_Homo sapiens_hsa006701.48507285
23Complement and coagulation cascades_Homo sapiens_hsa046101.48149798
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45034379
25Caffeine metabolism_Homo sapiens_hsa002321.42052604
26Nicotine addiction_Homo sapiens_hsa050331.41081174
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39387780
28Tryptophan metabolism_Homo sapiens_hsa003801.30128345
29Arachidonic acid metabolism_Homo sapiens_hsa005901.26896721
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24945407
31Fanconi anemia pathway_Homo sapiens_hsa034601.24721803
32Vitamin digestion and absorption_Homo sapiens_hsa049771.23140798
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21552661
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21455355
35ABC transporters_Homo sapiens_hsa020101.18074019
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17200159
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14466011
38Selenocompound metabolism_Homo sapiens_hsa004501.14380711
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12750417
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.12490876
41ECM-receptor interaction_Homo sapiens_hsa045121.10869141
42TGF-beta signaling pathway_Homo sapiens_hsa043501.10850868
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09801344
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09052603
45Glycerolipid metabolism_Homo sapiens_hsa005611.07945115
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.07625820
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06191633
48Olfactory transduction_Homo sapiens_hsa047401.05658656
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04831444
50Protein export_Homo sapiens_hsa030601.04493928
51Serotonergic synapse_Homo sapiens_hsa047261.03593001
52Starch and sucrose metabolism_Homo sapiens_hsa005001.03398997
53Retinol metabolism_Homo sapiens_hsa008301.03121158
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03031629
55Butanoate metabolism_Homo sapiens_hsa006501.00627273
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.99420653
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97560899
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97104417
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95143139
60GABAergic synapse_Homo sapiens_hsa047270.94314067
61Hedgehog signaling pathway_Homo sapiens_hsa043400.93518924
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92193227
63beta-Alanine metabolism_Homo sapiens_hsa004100.90516168
64Hippo signaling pathway_Homo sapiens_hsa043900.88916551
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87042811
66Mineral absorption_Homo sapiens_hsa049780.86514840
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84041636
68Steroid biosynthesis_Homo sapiens_hsa001000.81304606
69Tyrosine metabolism_Homo sapiens_hsa003500.77716888
70Chemical carcinogenesis_Homo sapiens_hsa052040.77393750
71Regulation of autophagy_Homo sapiens_hsa041400.77232009
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.76486170
73Insulin secretion_Homo sapiens_hsa049110.75592686
74Circadian rhythm_Homo sapiens_hsa047100.75493963
75Phenylalanine metabolism_Homo sapiens_hsa003600.74867516
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74038167
77Arginine and proline metabolism_Homo sapiens_hsa003300.73732514
78Dilated cardiomyopathy_Homo sapiens_hsa054140.73643347
79Vitamin B6 metabolism_Homo sapiens_hsa007500.73338468
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72839493
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72402101
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72053374
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71716899
84Oxytocin signaling pathway_Homo sapiens_hsa049210.71281549
85Ovarian steroidogenesis_Homo sapiens_hsa049130.69221874
86RNA degradation_Homo sapiens_hsa030180.69110325
87Homologous recombination_Homo sapiens_hsa034400.66684068
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.62824174
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62510656
90Biosynthesis of amino acids_Homo sapiens_hsa012300.62506728
91Asthma_Homo sapiens_hsa053100.61001620
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60673447
93Glutamatergic synapse_Homo sapiens_hsa047240.60362990
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60126581
95Basal transcription factors_Homo sapiens_hsa030220.60075290
96Long-term depression_Homo sapiens_hsa047300.59299675
97Protein digestion and absorption_Homo sapiens_hsa049740.59213818
98Graft-versus-host disease_Homo sapiens_hsa053320.58520673
99Cardiac muscle contraction_Homo sapiens_hsa042600.58497901
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58103866
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57364845
102Type I diabetes mellitus_Homo sapiens_hsa049400.56225688
103Insulin resistance_Homo sapiens_hsa049310.55376626
104Histidine metabolism_Homo sapiens_hsa003400.54708651
105Folate biosynthesis_Homo sapiens_hsa007900.53465183
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52021887
107Ras signaling pathway_Homo sapiens_hsa040140.50540068
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50517382
109Morphine addiction_Homo sapiens_hsa050320.50203732
110Dorso-ventral axis formation_Homo sapiens_hsa043200.48760789
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48410953
112FoxO signaling pathway_Homo sapiens_hsa040680.48280051
113Focal adhesion_Homo sapiens_hsa045100.47784152
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.47533716
115Hematopoietic cell lineage_Homo sapiens_hsa046400.47323613
116Platelet activation_Homo sapiens_hsa046110.46252948
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45654574
118cAMP signaling pathway_Homo sapiens_hsa040240.45534280
119Glucagon signaling pathway_Homo sapiens_hsa049220.44893718
120Gastric acid secretion_Homo sapiens_hsa049710.44118031
121MAPK signaling pathway_Homo sapiens_hsa040100.43852528
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43844492
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43612336
124Rap1 signaling pathway_Homo sapiens_hsa040150.42559818
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42181597
126Axon guidance_Homo sapiens_hsa043600.41902547
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.41618582
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41611622
129Fructose and mannose metabolism_Homo sapiens_hsa000510.41561789
130Type II diabetes mellitus_Homo sapiens_hsa049300.41518138
131Taste transduction_Homo sapiens_hsa047420.41501937
132RNA polymerase_Homo sapiens_hsa030200.41316285
133Calcium signaling pathway_Homo sapiens_hsa040200.41214161
134Autoimmune thyroid disease_Homo sapiens_hsa053200.41014533
135Adherens junction_Homo sapiens_hsa045200.39819664
136Wnt signaling pathway_Homo sapiens_hsa043100.39657804
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39493944
138Pyruvate metabolism_Homo sapiens_hsa006200.39012030
139Salivary secretion_Homo sapiens_hsa049700.38957147
140Notch signaling pathway_Homo sapiens_hsa043300.37219621
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.37108478
142Carbon metabolism_Homo sapiens_hsa012000.35803244
143Melanoma_Homo sapiens_hsa052180.34926117
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.34438811
145Pathways in cancer_Homo sapiens_hsa052000.32491600
146Proteoglycans in cancer_Homo sapiens_hsa052050.30802735
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30439698
148Circadian entrainment_Homo sapiens_hsa047130.30336496
149Renin secretion_Homo sapiens_hsa049240.30221871
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29567166

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