NPHS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.64532080
2epithelial cell differentiation involved in kidney development (GO:0035850)9.52047005
3acrosome reaction (GO:0007340)8.67444435
4fusion of sperm to egg plasma membrane (GO:0007342)8.42846712
5protein targeting to Golgi (GO:0000042)7.43825754
6response to mercury ion (GO:0046689)7.40910183
7metanephric nephron tubule development (GO:0072234)7.18494753
8metanephric tubule development (GO:0072170)7.18494753
9establishment of protein localization to Golgi (GO:0072600)7.15615431
10retrograde transport, vesicle recycling within Golgi (GO:0000301)7.02618879
11chromosome condensation (GO:0030261)6.82685987
12microtubule depolymerization (GO:0007019)6.76652615
13DNA packaging (GO:0006323)6.50635486
14metanephric nephron epithelium development (GO:0072243)6.48621696
15plasma membrane fusion (GO:0045026)6.32715841
16protein polyglutamylation (GO:0018095)6.31499402
17regulation of axon guidance (GO:1902667)6.26574070
18microtubule polymerization or depolymerization (GO:0031109)6.25001336
19endothelial cell chemotaxis (GO:0035767)6.22396146
20positive regulation of p38MAPK cascade (GO:1900745)6.21779742
21positive regulation of cell adhesion mediated by integrin (GO:0033630)6.19314488
22spermatid development (GO:0007286)6.14044401
23negative regulation of axon guidance (GO:1902668)6.12106660
24* excretion (GO:0007588)5.98326014
25spermatid nucleus differentiation (GO:0007289)5.97603374
26sperm capacitation (GO:0048240)5.93505051
27rRNA methylation (GO:0031167)5.86135168
28vascular endothelial growth factor signaling pathway (GO:0038084)5.57454881
29single strand break repair (GO:0000012)5.53455351
30coronary vasculature morphogenesis (GO:0060977)5.53309534
31seminiferous tubule development (GO:0072520)5.37241125
32spermatogenesis (GO:0007283)5.34547327
33male gamete generation (GO:0048232)5.32710782
34protein localization to Golgi apparatus (GO:0034067)5.30221927
35sperm-egg recognition (GO:0035036)5.27514452
36multicellular organism reproduction (GO:0032504)5.20111569
37activation of Rac GTPase activity (GO:0032863)5.19361501
38centriole replication (GO:0007099)5.19116916
39response to pheromone (GO:0019236)5.13086182
40polyol transport (GO:0015791)5.09334224
41angiotensin maturation (GO:0002003)5.08829469
42calcium ion-dependent exocytosis (GO:0017156)5.06422982
43cell adhesion mediated by integrin (GO:0033627)5.03720526
44negative regulation of inclusion body assembly (GO:0090084)4.98323746
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.97029158
46gamete generation (GO:0007276)4.92784760
47reproduction (GO:0000003)4.81599839
48rRNA modification (GO:0000154)4.81465503
49kidney mesenchyme development (GO:0072074)4.80582089
50negative regulation of homotypic cell-cell adhesion (GO:0034111)4.79098263
51binding of sperm to zona pellucida (GO:0007339)4.74369694
52cell migration involved in sprouting angiogenesis (GO:0002042)4.74200162
53surfactant homeostasis (GO:0043129)4.71526896
54regulation of centriole replication (GO:0046599)4.68297322
55single fertilization (GO:0007338)4.65963679
56venous blood vessel morphogenesis (GO:0048845)4.59424248
57nephron tubule development (GO:0072080)4.58974803
58regulation of axon extension involved in axon guidance (GO:0048841)4.55488737
59regulation of glomerular filtration (GO:0003093)4.54945553
60cell differentiation involved in kidney development (GO:0061005)4.53726781
61RNA destabilization (GO:0050779)4.51605804
62lymphangiogenesis (GO:0001946)4.50201476
63axonemal dynein complex assembly (GO:0070286)4.48673454
64phosphatidylethanolamine biosynthetic process (GO:0006646)4.48406045
65regulation of endothelial cell chemotaxis (GO:2001026)4.47236926
66sexual reproduction (GO:0019953)4.46985671
67centriole assembly (GO:0098534)4.46922960
68renal filtration (GO:0097205)4.43276933
69regulation of p38MAPK cascade (GO:1900744)4.42266059
70cell differentiation involved in metanephros development (GO:0072202)4.41550295
71cell-cell recognition (GO:0009988)4.35853649
72lung vasculature development (GO:0060426)4.29753708
73diaphragm development (GO:0060539)4.27539402
74mesonephros development (GO:0001823)4.26749171
75cilium or flagellum-dependent cell motility (GO:0001539)4.21003462
76metanephric mesenchyme development (GO:0072075)4.20691856
77auditory receptor cell stereocilium organization (GO:0060088)4.19311022
78protein depolymerization (GO:0051261)4.13480499
79phosphatidylethanolamine metabolic process (GO:0046337)4.10834390
80renal tubule development (GO:0061326)4.07664765
81fertilization (GO:0009566)4.07525842
82protein localization to endosome (GO:0036010)4.04520560
83endothelium development (GO:0003158)4.03931056
84collecting duct development (GO:0072044)4.01697828
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.01529116
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.01178108
87wound healing, spreading of epidermal cells (GO:0035313)3.98959167
88positive regulation of vascular permeability (GO:0043117)3.98580712
89microtubule severing (GO:0051013)3.95784051
90regulation of alkaline phosphatase activity (GO:0010692)3.95616521
91multicellular organismal reproductive process (GO:0048609)3.92777686
92cellular ketone body metabolic process (GO:0046950)3.88784274
93positive regulation of glomerulus development (GO:0090193)3.87851135
94musculoskeletal movement (GO:0050881)3.87720409
95multicellular organismal movement (GO:0050879)3.87720409
96skeletal muscle organ development (GO:0060538)3.84490913
97motile cilium assembly (GO:0044458)3.81985810
98vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.81369241
99mesenchymal cell differentiation involved in kidney development (GO:0072161)3.80668235
100mesenchymal cell differentiation involved in renal system development (GO:2001012)3.80668235
101renal system process involved in regulation of blood volume (GO:0001977)3.77721537
102chemical homeostasis within a tissue (GO:0048875)3.73689527
103dopaminergic neuron differentiation (GO:0071542)3.69838645
104nephron epithelium development (GO:0072009)3.67223010
105regulation of extracellular matrix disassembly (GO:0010715)3.65523889
106germ cell development (GO:0007281)3.65301112
107nucleus organization (GO:0006997)3.65060846
108regulation of cilium movement (GO:0003352)3.60822414
109nuclear pore complex assembly (GO:0051292)3.60432746
110actin filament depolymerization (GO:0030042)3.60011330
111regulation of Rab GTPase activity (GO:0032313)3.58585135
112positive regulation of Rab GTPase activity (GO:0032851)3.58585135
113epithelial cilium movement (GO:0003351)3.57723859
114regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.55593095
115sprouting angiogenesis (GO:0002040)3.55409775
116regulation of Rac protein signal transduction (GO:0035020)3.52705610
117response to parathyroid hormone (GO:0071107)3.52634944
118regulation of cell adhesion mediated by integrin (GO:0033628)3.51511010
119cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.47771117
120patterning of blood vessels (GO:0001569)3.47546384
121nephron tubule formation (GO:0072079)3.47294790
122microtubule nucleation (GO:0007020)3.41235783
123pattern specification involved in kidney development (GO:0061004)3.40981539
124cardiovascular system development (GO:0072358)3.40904164
125ketone body metabolic process (GO:1902224)3.39661464
126coenzyme catabolic process (GO:0009109)3.38726244
127positive regulation of cell junction assembly (GO:1901890)3.37801641
128positive regulation of focal adhesion assembly (GO:0051894)3.37801641
129cellular process involved in reproduction in multicellular organism (GO:0022412)3.37310887
130positive regulation of metanephros development (GO:0072216)3.36699117
131aminoglycoside antibiotic metabolic process (GO:0030647)3.36657541
132regulation of inclusion body assembly (GO:0090083)3.35751935
133platelet-derived growth factor receptor signaling pathway (GO:0048008)3.34056379
134blood vessel endothelial cell migration (GO:0043534)3.32924492
135myoblast fusion (GO:0007520)3.32575289
136protein heterotrimerization (GO:0070208)3.32496027
137mesodermal cell differentiation (GO:0048333)3.32224102
138mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.30636869
139positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.27883193
140glycerol ether metabolic process (GO:0006662)3.25756597
141lymph vessel development (GO:0001945)3.25548652
142cell volume homeostasis (GO:0006884)3.24516303
143positive regulation of adherens junction organization (GO:1903393)3.23813193
144negative regulation of axon extension involved in axon guidance (GO:0048843)3.23749457
145organic cation transport (GO:0015695)3.23644385
146regulation of corticosteroid hormone secretion (GO:2000846)3.23459902
147regulation of platelet aggregation (GO:0090330)3.22892400
148regulation of mesenchymal cell apoptotic process (GO:2001053)3.21811758
149phosphate ion transport (GO:0006817)3.21443490
150ureteric bud development (GO:0001657)3.21157995
151renal absorption (GO:0070293)3.20015147
152branching involved in salivary gland morphogenesis (GO:0060445)3.19869637
153cilium movement (GO:0003341)3.19643302
154regulation of apoptotic process involved in morphogenesis (GO:1902337)3.18647217
155stress fiber assembly (GO:0043149)3.16886083
156positive regulation of protein kinase C signaling (GO:0090037)3.06181780
157mesonephric tubule development (GO:0072164)3.05601133
158mesonephric epithelium development (GO:0072163)3.04175697
159renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.00904652
160* glomerular visceral epithelial cell development (GO:0072015)21.8393621
161glomerular basement membrane development (GO:0032836)21.1903751
162regulation of cell proliferation involved in kidney development (GO:1901722)2.99196682
163positive regulation of histone deacetylation (GO:0031065)2.97294595
164positive regulation of male gonad development (GO:2000020)2.97236793
165regulation of vascular permeability (GO:0043114)2.97034501
166syncytium formation by plasma membrane fusion (GO:0000768)2.95351601
167positive regulation of steroid hormone secretion (GO:2000833)2.93655929
168epithelial cell-cell adhesion (GO:0090136)2.92869887
169metanephric epithelium development (GO:0072207)2.88431064
170T-helper 1 type immune response (GO:0042088)2.88180720
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.87695907
172axon extension involved in axon guidance (GO:0048846)2.87695907
173negative regulation of platelet activation (GO:0010544)2.84880763
174positive regulation of axon extension (GO:0045773)2.82131618
175negative regulation of metanephros development (GO:0072217)2.80886970
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.80739846
177positive regulation of catenin import into nucleus (GO:0035413)2.80346625
178cardiac muscle cell proliferation (GO:0060038)2.79955963
179regulation of ruffle assembly (GO:1900027)2.79393056
180negative regulation of cell-cell adhesion (GO:0022408)2.72585466
181negative regulation of chemotaxis (GO:0050922)2.71920255
182endothelial cell migration (GO:0043542)2.69563180
183morphogenesis of an epithelial sheet (GO:0002011)2.67150710
184positive regulation of mesonephros development (GO:0061213)2.66930266
185wound healing, spreading of cells (GO:0044319)2.66451309
186negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.66250678
187muscle cell migration (GO:0014812)2.65545166
188positive regulation of actin filament bundle assembly (GO:0032233)2.65470652
189syncytium formation (GO:0006949)2.63520504
190positive regulation of phosphatase activity (GO:0010922)2.62285257
191glomerular filtration (GO:0003094)2.56778344
192* glomerular epithelial cell development (GO:0072310)19.0225673
193glomerulus development (GO:0032835)13.9191983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.75156837
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.54835009
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.93364965
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.86340493
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.47464225
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.88275051
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81049778
8EZH2_22144423_ChIP-Seq_EOC_Human2.79725875
9CLOCK_20551151_ChIP-Seq_293T_Human2.77396087
10FUS_26573619_Chip-Seq_HEK293_Human2.65048367
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.63456387
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.44646419
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44646419
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.44041349
15* WT1_25993318_ChIP-Seq_PODOCYTE_Human2.43681518
16IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.40088373
17CBP_20019798_ChIP-Seq_JUKART_Human2.40088373
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26336818
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25248395
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22536062
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21753330
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16728120
23EP300_21415370_ChIP-Seq_HL-1_Mouse2.13488022
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11207283
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.94446771
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91178763
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90757209
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.90040756
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89820286
30ER_23166858_ChIP-Seq_MCF-7_Human1.87662091
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86514124
32P300_19829295_ChIP-Seq_ESCs_Human1.85455422
33DROSHA_22980978_ChIP-Seq_HELA_Human1.84061883
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84019472
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.83557892
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.82840958
37* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78401022
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76500228
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76120140
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75348235
41GBX2_23144817_ChIP-Seq_PC3_Human1.74723083
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74317106
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72848947
44SMAD4_21799915_ChIP-Seq_A2780_Human1.72308916
45* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70289464
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.68611316
47* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67989323
48* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67989323
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.66397446
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.64918415
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61286351
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59301536
53TAF15_26573619_Chip-Seq_HEK293_Human1.58510520
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58505464
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58080456
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57964339
57AHR_22903824_ChIP-Seq_MCF-7_Human1.57250475
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56375799
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55039017
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52629573
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.52565483
62* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50879775
63AR_25329375_ChIP-Seq_VCAP_Human1.50386521
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49682140
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48720573
66* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48241185
67* ETV1_20927104_ChIP-Seq_GIST48_Human1.46940026
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.46856607
69* TBL1_22424771_ChIP-Seq_293T_Human1.46421197
70ZNF274_21170338_ChIP-Seq_K562_Hela1.45619013
71* HNFA_21074721_ChIP-Seq_CACO-2_Human1.44512596
72KDM2B_26808549_Chip-Seq_K562_Human1.43272986
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42490618
74STAT3_23295773_ChIP-Seq_U87_Human1.42427775
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42316959
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41786151
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.41533774
78* NFYB_21822215_ChIP-Seq_K562_Human1.41317432
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39979986
80* RAC3_21632823_ChIP-Seq_H3396_Human1.39606085
81* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39510493
82VDR_22108803_ChIP-Seq_LS180_Human1.39152659
83* PHF8_20622853_ChIP-Seq_HELA_Human1.39015131
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37487778
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37090048
86* RBPJ_21746931_ChIP-Seq_IB4_Human1.37012080
87* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36910769
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35238042
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33330490
90RXR_22108803_ChIP-Seq_LS180_Human1.32458801
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31570248
92KDM2B_26808549_Chip-Seq_REH_Human1.31480911
93MYC_19829295_ChIP-Seq_ESCs_Human1.31276343
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31242265
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30380314
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29592112
97RUNX2_22187159_ChIP-Seq_PCA_Human1.29344104
98* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.28575484
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.27542830
100ERA_21632823_ChIP-Seq_H3396_Human1.25820307
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24790400
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24557047
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23584802
104TAF2_19829295_ChIP-Seq_ESCs_Human1.23570182
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23481543
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23385248
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.23235954
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23162206
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22834619
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.22788672
111* NFYA_21822215_ChIP-Seq_K562_Human1.22405067
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22156656
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.20415534
114SOX2_20726797_ChIP-Seq_SW620_Human1.20230625
115* NANOG_18555785_Chip-Seq_ESCs_Mouse1.19672886
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17999562
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.17574713
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16980040
119* EZH2_27294783_Chip-Seq_ESCs_Mouse1.16229913
120GATA6_21074721_ChIP-Seq_CACO-2_Human1.16226963
121TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16035629
122RNF2_27304074_Chip-Seq_ESCs_Mouse1.15854719
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15725987
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14520382
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14184787
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12424810
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12324747
128YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11509765
129TCF4_23295773_ChIP-Seq_U87_Human1.11328945
130CEBPB_22108803_ChIP-Seq_LS180_Human1.10502790
131VDR_24787735_ChIP-Seq_THP-1_Human1.10036381
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09634737
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09347245
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09090576
135OCT4_20526341_ChIP-Seq_ESCs_Human1.08240531
136TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08203280
137BRD4_25478319_ChIP-Seq_HGPS_Human1.07951605
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07780019
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07502532
140NANOG_19829295_ChIP-Seq_ESCs_Human1.06327110
141SOX2_19829295_ChIP-Seq_ESCs_Human1.06327110
142CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06002364
143SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05703727
144TP63_23658742_ChIP-Seq_EP156T_Human1.05329975
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05304663
146CDX2_22108803_ChIP-Seq_LS180_Human1.05235786
147TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04911122
148ERG_20517297_ChIP-Seq_VCAP_Human1.04881238
149TCF4_22108803_ChIP-Seq_LS180_Human1.04605332
150SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04580685
151PRDM14_20953172_ChIP-Seq_ESCs_Human1.03888764
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03773731
153PIAS1_25552417_ChIP-Seq_VCAP_Human1.03654829
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03627815
155SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02452088
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01924202
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00680135
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00594604
159SMRT_27268052_Chip-Seq_Bcells_Human0.99924492
160MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98977014
161CJUN_26792858_Chip-Seq_BT549_Human0.98921694
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98573373
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98498081
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97931725
165TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97666471
166RING1B_27294783_Chip-Seq_NPCs_Mouse0.97658739
167SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94802142
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.94391082
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94165480
170TP53_18474530_ChIP-ChIP_U2OS_Human0.93966469
171EZH2_27304074_Chip-Seq_ESCs_Mouse0.92293476
172TP53_16413492_ChIP-PET_HCT116_Human0.92290465
173TBX20_22080862_ChIP-Seq_HEART_Mouse0.91497867
174TBX20_22328084_ChIP-Seq_HEART_Mouse0.91497867
175GATA2_19941826_ChIP-Seq_K562_Human0.91084785
176ESR1_20079471_ChIP-ChIP_T-47D_Human0.90856424
177GATA4_25053715_ChIP-Seq_YYC3_Human0.88126179
178ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87923699
179PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87423853
180ISL1_27105846_Chip-Seq_CPCs_Mouse0.87318810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.08604321
2MP0005623_abnormal_meninges_morphology6.79197738
3MP0004043_abnormal_pH_regulation6.64460363
4MP0003195_calcinosis6.39023745
5MP0004272_abnormal_basement_membrane5.44169972
6MP0002138_abnormal_hepatobiliary_system5.18876314
7MP0010368_abnormal_lymphatic_system4.76368714
8MP0003878_abnormal_ear_physiology4.64847306
9MP0005377_hearing/vestibular/ear_phenot4.64847306
10MP0004084_abnormal_cardiac_muscle4.46164514
11MP0001879_abnormal_lymphatic_vessel4.25023694
12MP0001661_extended_life_span3.69109461
13MP0005670_abnormal_white_adipose3.61804418
14MP0000537_abnormal_urethra_morphology3.37074913
15MP0003942_abnormal_urinary_system3.00651710
16MP0001765_abnormal_ion_homeostasis2.95922334
17MP0004036_abnormal_muscle_relaxation2.90136352
18MP0010030_abnormal_orbit_morphology2.70978269
19MP0003698_abnormal_male_reproductive2.63152208
20MP0000534_abnormal_ureter_morphology2.62197809
21* MP0002136_abnormal_kidney_physiology2.53233171
22* MP0002135_abnormal_kidney_morphology2.40922830
23MP0002928_abnormal_bile_duct2.40748781
24MP0001929_abnormal_gametogenesis2.27771539
25MP0009384_cardiac_valve_regurgitation2.21858521
26MP0005167_abnormal_blood-brain_barrier2.20095271
27MP0004019_abnormal_vitamin_homeostasis2.15538132
28* MP0009643_abnormal_urine_homeostasis2.12653931
29* MP0000230_abnormal_systemic_arterial2.12274994
30MP0002168_other_aberrant_phenotype2.03045160
31MP0001756_abnormal_urination1.94951927
32MP0003879_abnormal_hair_cell1.94474825
33MP0001485_abnormal_pinna_reflex1.94413695
34MP0005636_abnormal_mineral_homeostasis1.93744724
35MP0001348_abnormal_lacrimal_gland1.85921625
36MP0003283_abnormal_digestive_organ1.78029276
37MP0005503_abnormal_tendon_morphology1.76672628
38MP0003941_abnormal_skin_development1.76495608
39MP0000013_abnormal_adipose_tissue1.71409450
40MP0001486_abnormal_startle_reflex1.70547751
41MP0005197_abnormal_uvea_morphology1.67818666
42* MP0005332_abnormal_amino_acid1.67235349
43MP0005395_other_phenotype1.64373548
44MP0002295_abnormal_pulmonary_circulatio1.60182014
45MP0003091_abnormal_cell_migration1.58636857
46MP0003011_delayed_dark_adaptation1.52155084
47MP0005187_abnormal_penis_morphology1.51714181
48MP0000678_abnormal_parathyroid_gland1.50933136
49MP0003646_muscle_fatigue1.44251714
50MP0008961_abnormal_basal_metabolism1.41479092
51MP0002161_abnormal_fertility/fecundity1.40093875
52MP0004859_abnormal_synaptic_plasticity1.37987912
53MP0003566_abnormal_cell_adhesion1.37567731
54MP0004233_abnormal_muscle_weight1.35495455
55MP0000579_abnormal_nail_morphology1.34138749
56MP0001915_intracranial_hemorrhage1.31641705
57MP0001784_abnormal_fluid_regulation1.25451333
58MP0004185_abnormal_adipocyte_glucose1.25346426
59* MP0002128_abnormal_blood_circulation1.23413372
60MP0006276_abnormal_autonomic_nervous1.23406099
61MP0006138_congestive_heart_failure1.22090670
62MP0000767_abnormal_smooth_muscle1.20228638
63* MP0001614_abnormal_blood_vessel1.18338144
64MP0005220_abnormal_exocrine_pancreas1.18234828
65MP0008775_abnormal_heart_ventricle1.16870570
66MP0000538_abnormal_urinary_bladder1.15994606
67MP0000747_muscle_weakness1.15770884
68MP0010307_abnormal_tumor_latency1.13938788
69MP0003718_maternal_effect1.13411367
70MP0003279_aneurysm1.13212577
71MP0003937_abnormal_limbs/digits/tail_de1.13136621
72MP0005248_abnormal_Harderian_gland1.11152867
73MP0003115_abnormal_respiratory_system1.10860203
74MP0005193_abnormal_anterior_eye1.07426267
75MP0000026_abnormal_inner_ear1.06802005
76MP0002090_abnormal_vision1.05994669
77MP0002132_abnormal_respiratory_system1.04852096
78MP0000516_abnormal_urinary_system1.03789579
79MP0005367_renal/urinary_system_phenotyp1.03789579
80MP0005165_increased_susceptibility_to1.03774752
81MP0003303_peritoneal_inflammation1.03744780
82MP0000003_abnormal_adipose_tissue1.02569594
83MP0002210_abnormal_sex_determination1.02406858
84MP0010386_abnormal_urinary_bladder1.00988793
85MP0005360_urolithiasis0.99977022
86MP0001544_abnormal_cardiovascular_syste0.98558555
87MP0005385_cardiovascular_system_phenoty0.98558555
88MP0003300_gastrointestinal_ulcer0.98545340
89MP0000163_abnormal_cartilage_morphology0.96749368
90MP0005666_abnormal_adipose_tissue0.95606203
91MP0001346_abnormal_lacrimal_gland0.94770547
92MP0004742_abnormal_vestibular_system0.94471563
93MP0002925_abnormal_cardiovascular_devel0.93106680
94MP0005310_abnormal_salivary_gland0.92774747
95MP0003943_abnormal_hepatobiliary_system0.91044443
96MP0003935_abnormal_craniofacial_develop0.88254342
97MP0003045_fibrosis0.87882130
98MP0001324_abnormal_eye_pigmentation0.87767564
99MP0005535_abnormal_body_temperature0.87626476
100MP0003705_abnormal_hypodermis_morpholog0.87081025
101MP0001963_abnormal_hearing_physiology0.85692253
102MP0009115_abnormal_fat_cell0.85210717
103MP0000477_abnormal_intestine_morphology0.83574070
104MP0001145_abnormal_male_reproductive0.82562179
105MP0001286_abnormal_eye_development0.81111466
106MP0005379_endocrine/exocrine_gland_phen0.80912024
107MP0002972_abnormal_cardiac_muscle0.80634140
108MP0002932_abnormal_joint_morphology0.80570222
109MP0006072_abnormal_retinal_apoptosis0.78717145
110MP0009053_abnormal_anal_canal0.78095914
111MP0000653_abnormal_sex_gland0.77462077
112MP0002249_abnormal_larynx_morphology0.76954430
113MP0000858_altered_metastatic_potential0.76507622
114MP0005595_abnormal_vascular_smooth0.76095180
115MP0000462_abnormal_digestive_system0.75076803
116MP0001501_abnormal_sleep_pattern0.74856179
117MP0002697_abnormal_eye_size0.73649571
118MP0004484_altered_response_of0.73311202
119MP0002998_abnormal_bone_remodeling0.73144935
120MP0005551_abnormal_eye_electrophysiolog0.71842710
121MP0002139_abnormal_hepatobiliary_system0.71532176
122MP0002115_abnormal_skeleton_extremities0.70117037
123MP0003252_abnormal_bile_duct0.68620645
124MP0002113_abnormal_skeleton_development0.68091296
125MP0003385_abnormal_body_wall0.66953946
126MP0002933_joint_inflammation0.66766438
127MP0005620_abnormal_muscle_contractility0.66510559
128MP0005451_abnormal_body_composition0.66388147
129MP0003638_abnormal_response/metabolism_0.65277899
130MP0005508_abnormal_skeleton_morphology0.64272277
131MP0004264_abnormal_extraembryonic_tissu0.64015010
132MP0010630_abnormal_cardiac_muscle0.63550975
133MP0002233_abnormal_nose_morphology0.63065653
134MP0005375_adipose_tissue_phenotype0.61604406
135MP0004885_abnormal_endolymph0.61554550
136MP0002896_abnormal_bone_mineralization0.61535590
137MP0005084_abnormal_gallbladder_morpholo0.61252910
138MP0005253_abnormal_eye_physiology0.60842814
139MP0000470_abnormal_stomach_morphology0.59130831
140MP0009697_abnormal_copulation0.57834788
141MP0001175_abnormal_lung_morphology0.56793021
142MP0003938_abnormal_ear_development0.56504373
143MP0001299_abnormal_eye_distance/0.55938477
144MP0005166_decreased_susceptibility_to0.55732571
145MP0003959_abnormal_lean_body0.54216260
146MP0002229_neurodegeneration0.53343074
147MP0002282_abnormal_trachea_morphology0.53270193
148MP0001293_anophthalmia0.53171037
149MP0002234_abnormal_pharynx_morphology0.53009338
150MP0008872_abnormal_physiological_respon0.52928886
151MP0001270_distended_abdomen0.52474187
152MP0003828_pulmonary_edema0.52109337
153MP0002269_muscular_atrophy0.52028033
154MP0001984_abnormal_olfaction0.51692822
155MP0004085_abnormal_heartbeat0.51146786
156MP0002069_abnormal_eating/drinking_beha0.51078911
157MP0004133_heterotaxia0.49175249
158MP0009780_abnormal_chondrocyte_physiolo0.49058823
159MP0005391_vision/eye_phenotype0.46328566
160MP0001944_abnormal_pancreas_morphology0.44767106
161MP0003936_abnormal_reproductive_system0.44650572
162MP0000049_abnormal_middle_ear0.42455288
163MP0005423_abnormal_somatic_nervous0.41616213
164MP0002127_abnormal_cardiovascular_syste0.39006149
165MP0003137_abnormal_impulse_conducting0.38385418
166MP0008877_abnormal_DNA_methylation0.37152182
167MP0002108_abnormal_muscle_morphology0.35885697
168MP0002067_abnormal_sensory_capabilities0.34758153
169MP0002109_abnormal_limb_morphology0.34621696
170MP0001958_emphysema0.34019530

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)9.08040591
2Hyperactive renin-angiotensin system (HP:0000841)8.81198973
3Nephritis (HP:0000123)8.16723151
4Glomerulonephritis (HP:0000099)8.11278492
5* Abnormal albumin level (HP:0012116)7.77965210
6* Hypoalbuminemia (HP:0003073)7.77965210
7* Glomerulosclerosis (HP:0000096)7.65988161
8Abnormality of chloride homeostasis (HP:0011422)6.98143690
9Polyuria (HP:0000103)6.75155352
10Hyperaldosteronism (HP:0000859)6.33582774
11Abnormal urine output (HP:0012590)6.17907690
12Renal salt wasting (HP:0000127)6.02050281
13Tubular atrophy (HP:0000092)5.98135540
14Tetany (HP:0001281)5.97923507
15* Stage 5 chronic kidney disease (HP:0003774)5.62819021
16Polydipsia (HP:0001959)5.58653978
17Abnormal drinking behavior (HP:0030082)5.58653978
18Abnormality of renal excretion (HP:0011036)5.57283663
19Hypoproteinemia (HP:0003075)5.46721891
20Abnormality of renin-angiotensin system (HP:0000847)5.28039264
21* Nephrotic syndrome (HP:0000100)5.01901539
22Neonatal respiratory distress (HP:0002643)5.00244408
23Metaphyseal dysplasia (HP:0100255)4.97697362
24Hypokalemia (HP:0002900)4.88503425
25Corneal erosion (HP:0200020)4.83593753
26Alkalosis (HP:0001948)4.57553182
27Nonprogressive disorder (HP:0003680)4.55596485
28Abnormality of potassium homeostasis (HP:0011042)4.36002957
29* Proteinuria (HP:0000093)4.10076517
30Hematuria (HP:0000790)4.02898797
31Lymphangioma (HP:0100764)3.99402273
32Generalized aminoaciduria (HP:0002909)3.67122468
33Severe visual impairment (HP:0001141)3.62951412
34Proximal tubulopathy (HP:0000114)3.50648940
35Tubulointerstitial fibrosis (HP:0005576)3.40318291
36Metaphyseal cupping (HP:0003021)3.39834362
37Deep venous thrombosis (HP:0002625)3.34380705
38Polar cataract (HP:0010696)3.31964910
39Increased purine levels (HP:0004368)3.30313208
40Hyperuricemia (HP:0002149)3.30313208
41Tubulointerstitial nephritis (HP:0001970)3.28521238
42Abnormal tarsal ossification (HP:0008369)3.22338683
43Abnormality of sodium homeostasis (HP:0010931)3.19598644
44Chronic hepatic failure (HP:0100626)3.18286445
45Aplasia of the musculature (HP:0100854)2.93192152
46Hyponatremia (HP:0002902)2.93136275
47Anomalous pulmonary venous return (HP:0010772)2.91224786
48Abnormality of purine metabolism (HP:0004352)2.90393804
49Enlarged epiphyses (HP:0010580)2.86523650
50Pterygium (HP:0001059)2.86010511
51Ridged nail (HP:0001807)2.85056223
52Adrenal overactivity (HP:0002717)2.83479335
53Coronal craniosynostosis (HP:0004440)2.80119921
54Asymmetric septal hypertrophy (HP:0001670)2.77435726
55Hyperkalemia (HP:0002153)2.76849370
56Gout (HP:0001997)2.76418571
57Visceral angiomatosis (HP:0100761)2.75686723
58Hypophosphatemia (HP:0002148)2.74029863
59Abnormality of the renal medulla (HP:0100957)2.73746571
60Persistence of primary teeth (HP:0006335)2.69290564
61Facial shape deformation (HP:0011334)2.68186641
62Potter facies (HP:0002009)2.68186641
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.66753895
64Absent/shortened dynein arms (HP:0200106)2.66753895
65Retinal atrophy (HP:0001105)2.66362481
66Hypoparathyroidism (HP:0000829)2.66122777
67Down-sloping shoulders (HP:0200021)2.62952883
68Glycosuria (HP:0003076)2.59765100
69Abnormality of urine glucose concentration (HP:0011016)2.59765100
70Concave nail (HP:0001598)2.58705679
71Hyperphosphaturia (HP:0003109)2.58323796
72Osteomalacia (HP:0002749)2.57743379
73Hemangiomatosis (HP:0007461)2.54043287
74Abnormality of the pulmonary veins (HP:0011718)2.50337485
75Increased circulating renin level (HP:0000848)2.47687714
76Abnormality of the fingertips (HP:0001211)2.46146232
77Hematochezia (HP:0002573)2.39115401
78Abnormality of macular pigmentation (HP:0008002)2.37960322
79Delayed epiphyseal ossification (HP:0002663)2.34176929
80Amelogenesis imperfecta (HP:0000705)2.32403315
81Abnormality of fatty-acid metabolism (HP:0004359)2.31253331
82Venous insufficiency (HP:0005293)2.30768799
83Large eyes (HP:0001090)2.30037249
84Hip contracture (HP:0003273)2.29648914
85Abnormal foot bone ossification (HP:0010675)2.28850745
86Autoimmune thrombocytopenia (HP:0001973)2.27396233
87Dehydration (HP:0001944)2.26296748
88Cone-rod dystrophy (HP:0000548)2.23995288
89Hypophosphatemic rickets (HP:0004912)2.22559631
90Portal hypertension (HP:0001409)2.19103794
91Menstrual irregularities (HP:0000858)2.18105341
92Polycythemia (HP:0001901)2.15666331
93Nephrocalcinosis (HP:0000121)2.15266382
94Aortic aneurysm (HP:0004942)2.15013806
95Hypotension (HP:0002615)2.14324416
96Abnormal urine phosphate concentration (HP:0012599)2.12945863
97Rickets (HP:0002748)2.10323446
98Choanal stenosis (HP:0000452)2.09394333
99Germ cell neoplasia (HP:0100728)2.07411008
100* Rapidly progressive (HP:0003678)2.05733775
101Ankle contracture (HP:0006466)2.05717556
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02197654
103Hypokalemic alkalosis (HP:0001949)2.01680300
104Shawl scrotum (HP:0000049)2.00460615
105Mesangial abnormality (HP:0001966)14.6967977
106* Focal segmental glomerulosclerosis (HP:0000097)10.0064599
107Abnormality of the hepatic vasculature (HP:0006707)1.98835347
108Midline defect of the nose (HP:0004122)1.94954096
109Abnormal ciliary motility (HP:0012262)1.93580885
110Exostoses (HP:0100777)1.93195483
111Hypomagnesemia (HP:0002917)1.93031679
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.92665646
113Abnormality of nucleobase metabolism (HP:0010932)1.90293069
114Glomerulopathy (HP:0100820)1.89999211
115Bicornuate uterus (HP:0000813)1.89941867
116Attenuation of retinal blood vessels (HP:0007843)1.88258410
117Generalized muscle weakness (HP:0003324)1.87283272
118Abnormal respiratory motile cilium physiology (HP:0012261)1.87061730
119Tubulointerstitial abnormality (HP:0001969)1.86560023
120Abnormality of the renal cortex (HP:0011035)1.86546416
121Male infertility (HP:0003251)1.86287005
122Renovascular hypertension (HP:0100817)1.86144636
123Abnormality of proline metabolism (HP:0010907)1.85080385
124Hydroxyprolinuria (HP:0003080)1.85080385
125Interstitial pulmonary disease (HP:0006530)1.83914720
126Knee flexion contracture (HP:0006380)1.83857511
127Testicular neoplasm (HP:0010788)1.83349891
128Abnormality of the peritoneum (HP:0002585)1.82948255
129Absent phalangeal crease (HP:0006109)1.82343696
130Recurrent corneal erosions (HP:0000495)1.81029664
131Venous abnormality (HP:0002624)1.80742450
132Intellectual disability, moderate (HP:0002342)1.80008487
133Aqueductal stenosis (HP:0002410)1.79173623
134Bony spicule pigmentary retinopathy (HP:0007737)1.78233107
135Hypoplastic left heart (HP:0004383)1.77086244
136Enlarged kidneys (HP:0000105)1.74785394
137Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73689547
138Hypoalphalipoproteinemia (HP:0003233)1.73535713
139Chondrocalcinosis (HP:0000934)1.71937516
140Abdominal distention (HP:0003270)1.71937160
141Cavernous hemangioma (HP:0001048)1.71925082
142Hypertensive crisis (HP:0100735)1.68830591
143Seborrheic dermatitis (HP:0001051)1.68085981
144Limited hip movement (HP:0008800)1.65492808
145Pancreatic cysts (HP:0001737)1.65106899
146Renal duplication (HP:0000075)1.64180414
147Hypoplasia of the thymus (HP:0000778)1.62242096
148Nasal polyposis (HP:0100582)1.61887039
149Turricephaly (HP:0000262)1.60959089
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.60882963
151Resting tremor (HP:0002322)1.60841060
152Abnormal respiratory motile cilium morphology (HP:0005938)1.58390854
153Abnormal respiratory epithelium morphology (HP:0012253)1.58390854
154Abnormality of Sharpey fibers (HP:0100685)1.57980211
155Advanced eruption of teeth (HP:0006288)1.56391573
156Cerebral hemorrhage (HP:0001342)1.56180907
157Hypercalciuria (HP:0002150)1.55526448
158Nephronophthisis (HP:0000090)1.55304780
159Hyperthyroidism (HP:0000836)1.55229497
160Thin bony cortex (HP:0002753)1.54899955
161Aneurysm (HP:0002617)1.54029040
162Hypoplasia of the iris (HP:0007676)1.53440291
163Progressive sensorineural hearing impairment (HP:0000408)1.53263728
164Abnormality of magnesium homeostasis (HP:0004921)1.52962523
165Abnormality of carpal bone ossification (HP:0006257)1.51836564
166Abnormality of renal resorption (HP:0011038)1.51482969
167Aplasia/Hypoplasia of the earlobes (HP:0009906)1.50876246
168Esophageal varix (HP:0002040)1.50355118
169Infertility (HP:0000789)1.48930810
170Progressive cerebellar ataxia (HP:0002073)1.46032594
171Abnormal finger flexion creases (HP:0006143)1.42350303
172Renal dysplasia (HP:0000110)1.41987019
173Spontaneous hematomas (HP:0007420)1.41841354
174Abnormality of dental color (HP:0011073)1.41286605
175Thrombophlebitis (HP:0004418)1.39034808
176Gonadal dysgenesis (HP:0000133)1.32457103
177Rectal prolapse (HP:0002035)1.32193998
178Exotropia (HP:0000577)1.31756655
179Increased corneal curvature (HP:0100692)1.31201544
180Keratoconus (HP:0000563)1.31201544
181Patellar dislocation (HP:0002999)1.31102811
182Broad metatarsal (HP:0001783)1.30615727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.40719660
2PLK45.86760605
3PAK44.55590942
4OXSR14.41690454
5WNK44.38727026
6TIE14.33568987
7MYLK3.85982113
8TGFBR23.46582311
9STK393.34635662
10INSRR3.33376550
11KDR3.06452630
12BRD42.97790350
13PNCK2.52523983
14TESK12.42778711
15MAP4K22.33144347
16PLK22.15572598
17TGFBR12.07295827
18SGK21.98417311
19CAMK2B1.97935922
20PIK3CG1.93463467
21EPHB11.90726968
22CDK191.80301050
23STK38L1.73095602
24DDR21.71061432
25PDGFRA1.70893496
26LATS11.70059405
27NTRK11.68829482
28TRIB31.64321561
29SGK2231.62849115
30SGK4941.62849115
31FGFR41.50376197
32MST41.50166962
33STK381.45755515
34MAP3K71.34999318
35SGK31.33935443
36ROCK11.32052654
37PAK21.30136485
38FER1.16055461
39PAK31.15012002
40KIT1.10170440
41NME11.03660305
42LRRK21.01957913
43BRSK20.99357724
44GSK3A0.95960467
45ABL20.94969946
46PRKCH0.88693665
47MAP2K10.88318765
48NEK60.84874695
49CDK120.84718876
50PTK60.84294669
51LATS20.82928078
52JAK10.77550724
53SIK10.77065475
54ERN10.76747778
55PDGFRB0.73236005
56FGFR20.73146602
57WNK10.72294391
58TYK20.70846505
59STK100.69258449
60BMPR1B0.68937082
61MAP3K130.68044665
62MAPK90.67292183
63MAP3K40.65579453
64MST1R0.63923335
65PDPK10.61635579
66MAP3K90.60266211
67JAK20.59330553
68CDK150.59325650
69MAPK150.57956122
70GRK10.56867584
71PRKCE0.56438595
72BMX0.55645376
73NTRK30.55261163
74PRKAA20.55164976
75CDK180.54249431
76DYRK1B0.53948969
77CDK11A0.53655167
78PDK20.53246970
79TYRO30.52529660
80RIPK10.52244853
81NEK90.52014496
82SRC0.51957969
83CAMK1G0.51904878
84CDK140.51492128
85ZAP700.49234059
86FES0.49211260
87PTK20.48519479
88FGFR10.48260724
89MAP3K120.47925691
90FYN0.47776049
91CAMKK20.45778767
92AKT30.45557084
93WNK30.44483463
94PRKAA10.44356503
95MAPK120.43512314
96PTK2B0.42337723
97FGFR30.42178107
98IGF1R0.41707505
99PRKD10.41707014
100PRKD30.40506352
101MTOR0.39468687
102PRKD20.38513522
103BRSK10.37189464
104FRK0.36953892
105SGK10.36421863
106CDK30.36382932
107NEK10.36179410
108PKN10.35680972
109MARK20.34374566
110MARK10.33349363
111EGFR0.31861464
112SIK20.31697939
113CDK50.31628088
114PDK10.31624873
115MAP2K20.30693166
116KSR20.30386245
117ROCK20.30098908
118PRKG20.29321288
119PRKG10.28712289
120MAPKAPK50.28548587
121CAMK10.28454441
122CAMK1D0.28144734
123MAPK40.27899474
124TTN0.27777169
125PAK60.26937453
126HIPK20.26919639
127PRKACB0.26838923
128ABL10.26670856
129ADRBK10.26111983
130PRKACG0.25909224
131TBK10.25418354
132CDK70.24988968
133MAP3K20.24893320
134AKT20.23879499
135PRKACA0.23463866
136SCYL20.23018313
137TAF10.20185687
138PINK10.19585361
139BRAF0.19044085
140MKNK20.18916714
141PRKCG0.17106538
142CSNK1A10.17059367
143NLK0.16755715
144MAPK10.15331846
145GSK3B0.14743935
146PRKCB0.13682372
147STK30.13085449
148RPS6KA10.11652379
149PRKCZ0.10961874
150CDK20.10361232
151BCKDK0.09981992
152MAPK80.09763115
153RPS6KA20.09592807
154CDK10.08447032
155MAP3K10.08223592
156ACVR1B0.08217890
157CAMK40.07574154
158NUAK10.07061816
159MAP3K110.05718304
160MAP3K60.05712902
161MAPK140.02774819
162RPS6KA30.02100560
163MAPK100.01351294
164STK240.00437321
165MET0.00394481
166PRKCA0.00272514

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.22507650
2ECM-receptor interaction_Homo sapiens_hsa045124.83567420
3Renin-angiotensin system_Homo sapiens_hsa046144.56506995
4Fatty acid biosynthesis_Homo sapiens_hsa000614.55787006
5Small cell lung cancer_Homo sapiens_hsa052223.17800525
6Axon guidance_Homo sapiens_hsa043603.12571336
7Focal adhesion_Homo sapiens_hsa045102.87186917
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.84555111
9Protein digestion and absorption_Homo sapiens_hsa049742.83938828
10Olfactory transduction_Homo sapiens_hsa047402.83559811
11Amoebiasis_Homo sapiens_hsa051462.82523863
12Butanoate metabolism_Homo sapiens_hsa006502.78060161
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54533885
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.43604018
15Phenylalanine metabolism_Homo sapiens_hsa003602.02840489
16Dilated cardiomyopathy_Homo sapiens_hsa054141.90569149
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87046978
18N-Glycan biosynthesis_Homo sapiens_hsa005101.81424576
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78685225
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77762161
21Tryptophan metabolism_Homo sapiens_hsa003801.63092236
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61157139
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.58336529
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52116541
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49157433
26Arginine and proline metabolism_Homo sapiens_hsa003301.48514291
27Taste transduction_Homo sapiens_hsa047421.47595525
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.46206693
29Propanoate metabolism_Homo sapiens_hsa006401.44988464
30Proteoglycans in cancer_Homo sapiens_hsa052051.43270485
31beta-Alanine metabolism_Homo sapiens_hsa004101.42624945
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35626703
33Renal cell carcinoma_Homo sapiens_hsa052111.35239721
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32529280
35Retinol metabolism_Homo sapiens_hsa008301.32435567
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32072102
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.29442735
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27669560
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27503643
40Bladder cancer_Homo sapiens_hsa052191.26132329
41Histidine metabolism_Homo sapiens_hsa003401.24673817
42Rap1 signaling pathway_Homo sapiens_hsa040151.21178966
43Adherens junction_Homo sapiens_hsa045201.19206119
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14407247
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12547485
46Pancreatic cancer_Homo sapiens_hsa052121.09768346
47Renin secretion_Homo sapiens_hsa049241.09282961
48Fatty acid metabolism_Homo sapiens_hsa012121.08036272
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05574044
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04982776
51VEGF signaling pathway_Homo sapiens_hsa043701.04511961
52Collecting duct acid secretion_Homo sapiens_hsa049661.03556045
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03007963
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00643132
55Tight junction_Homo sapiens_hsa045301.00478352
56Complement and coagulation cascades_Homo sapiens_hsa046101.00449741
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.99540325
58Phototransduction_Homo sapiens_hsa047440.99507955
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98252427
60Platelet activation_Homo sapiens_hsa046110.97708146
61Gastric acid secretion_Homo sapiens_hsa049710.97018809
62RNA transport_Homo sapiens_hsa030130.96715176
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.96208479
64Arginine biosynthesis_Homo sapiens_hsa002200.95324692
65Glycerolipid metabolism_Homo sapiens_hsa005610.93742000
66Vitamin B6 metabolism_Homo sapiens_hsa007500.93049944
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92626988
68Pathways in cancer_Homo sapiens_hsa052000.91016946
69Hippo signaling pathway_Homo sapiens_hsa043900.89776693
70Sulfur relay system_Homo sapiens_hsa041220.88100572
71mTOR signaling pathway_Homo sapiens_hsa041500.85602789
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82862915
73Vitamin digestion and absorption_Homo sapiens_hsa049770.82217531
74Lysine degradation_Homo sapiens_hsa003100.81799207
75Antigen processing and presentation_Homo sapiens_hsa046120.79833593
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.79799747
77Gap junction_Homo sapiens_hsa045400.79527516
78Starch and sucrose metabolism_Homo sapiens_hsa005000.78412699
79Dorso-ventral axis formation_Homo sapiens_hsa043200.76817877
80Hedgehog signaling pathway_Homo sapiens_hsa043400.76638648
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.76454885
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75969976
83Chemical carcinogenesis_Homo sapiens_hsa052040.73985743
84Cardiac muscle contraction_Homo sapiens_hsa042600.73846583
85Thyroid hormone synthesis_Homo sapiens_hsa049180.73814173
86Endocytosis_Homo sapiens_hsa041440.73209798
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73066076
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.72131620
89Type II diabetes mellitus_Homo sapiens_hsa049300.72080818
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70624261
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69936707
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67749470
93Ras signaling pathway_Homo sapiens_hsa040140.67114115
94Viral myocarditis_Homo sapiens_hsa054160.64483968
95Nitrogen metabolism_Homo sapiens_hsa009100.64241658
96Pancreatic secretion_Homo sapiens_hsa049720.62575740
97cAMP signaling pathway_Homo sapiens_hsa040240.62546825
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.62140236
99Serotonergic synapse_Homo sapiens_hsa047260.61675079
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61040516
101PPAR signaling pathway_Homo sapiens_hsa033200.60923010
102Calcium signaling pathway_Homo sapiens_hsa040200.60843925
103Glutamatergic synapse_Homo sapiens_hsa047240.60114744
104Morphine addiction_Homo sapiens_hsa050320.59419351
105Circadian rhythm_Homo sapiens_hsa047100.59084057
106Tyrosine metabolism_Homo sapiens_hsa003500.59081738
107Glioma_Homo sapiens_hsa052140.58007026
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57281404
109Bile secretion_Homo sapiens_hsa049760.56659891
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52080617
111Salivary secretion_Homo sapiens_hsa049700.50680019
112Phagosome_Homo sapiens_hsa041450.50677383
113Oxytocin signaling pathway_Homo sapiens_hsa049210.48599614
114Type I diabetes mellitus_Homo sapiens_hsa049400.48513209
115Prostate cancer_Homo sapiens_hsa052150.48156934
116Long-term potentiation_Homo sapiens_hsa047200.46079759
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45472380
118Estrogen signaling pathway_Homo sapiens_hsa049150.44329265
119MicroRNAs in cancer_Homo sapiens_hsa052060.43491156
120Mineral absorption_Homo sapiens_hsa049780.42931794
121Nicotine addiction_Homo sapiens_hsa050330.40830285
122Autoimmune thyroid disease_Homo sapiens_hsa053200.40610280
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.39767724
124Non-small cell lung cancer_Homo sapiens_hsa052230.36922359
125Lysosome_Homo sapiens_hsa041420.36871762
126Rheumatoid arthritis_Homo sapiens_hsa053230.36437704
127Graft-versus-host disease_Homo sapiens_hsa053320.35723541
128Allograft rejection_Homo sapiens_hsa053300.35674811
129Insulin secretion_Homo sapiens_hsa049110.33937685
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33712759
131FoxO signaling pathway_Homo sapiens_hsa040680.33677151
132Chronic myeloid leukemia_Homo sapiens_hsa052200.32083431
133Insulin resistance_Homo sapiens_hsa049310.31204894
134Melanoma_Homo sapiens_hsa052180.29693606
135Circadian entrainment_Homo sapiens_hsa047130.29080665
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28983030
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28423243
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28030998
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27713642
140Wnt signaling pathway_Homo sapiens_hsa043100.27661812
141Shigellosis_Homo sapiens_hsa051310.27351369
142ABC transporters_Homo sapiens_hsa020100.26680192
143Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26667091
144Long-term depression_Homo sapiens_hsa047300.26543539
145Vibrio cholerae infection_Homo sapiens_hsa051100.26360910
146HIF-1 signaling pathway_Homo sapiens_hsa040660.26107734
147Salmonella infection_Homo sapiens_hsa051320.25400641
148Sphingolipid metabolism_Homo sapiens_hsa006000.24970195
149Notch signaling pathway_Homo sapiens_hsa043300.23772800
150Fatty acid degradation_Homo sapiens_hsa000710.23654226
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22976798
152MAPK signaling pathway_Homo sapiens_hsa040100.22694215
153Cocaine addiction_Homo sapiens_hsa050300.22556720
154Choline metabolism in cancer_Homo sapiens_hsa052310.21648204
155Inositol phosphate metabolism_Homo sapiens_hsa005620.21480641
156Endometrial cancer_Homo sapiens_hsa052130.20920422
157Cholinergic synapse_Homo sapiens_hsa047250.20819285
158Toxoplasmosis_Homo sapiens_hsa051450.20319667

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »