ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.42070611
2	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.25769992
3	positive regulation of synapse maturation (GO:0090129)	4.15399355
4	glutamate secretion (GO:0014047)	4.09118080
5	cerebellar granule cell differentiation (GO:0021707)	4.08049975
6	synaptic vesicle maturation (GO:0016188)	3.99824131
7	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.89399763
8	regulation of ARF protein signal transduction (GO:0032012)	3.78388156
9	sodium ion export (GO:0071436)	3.75737875
10	synaptic vesicle exocytosis (GO:0016079)	3.74330933
11	regulation of ARF GTPase activity (GO:0032312)	3.68784631
12	locomotory exploration behavior (GO:0035641)	3.59989593
13	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.57991695
14	regulation of synaptic vesicle exocytosis (GO:2000300)	3.46118290
15	cellular potassium ion homeostasis (GO:0030007)	3.45821757
16	regulation of synapse maturation (GO:0090128)	3.45165637
17	positive regulation of CREB transcription factor activity (GO:0032793)	3.29216353
18	vocalization behavior (GO:0071625)	3.28750031
19	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.21926716
20	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.21531245
21	neurotransmitter-gated ion channel clustering (GO:0072578)	3.16229436
22	neuronal ion channel clustering (GO:0045161)	3.11273621
23	neurotransmitter secretion (GO:0007269)	3.09907982
24	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.08864205
25	lung epithelium development (GO:0060428)	3.08692529
26	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	3.07953213
27	cell migration in hindbrain (GO:0021535)	3.07577073
28	regulation of neuronal synaptic plasticity (GO:0048168)	3.05752800
29	histone H3-K9 demethylation (GO:0033169)	3.04273258
30	regulation of glutamate receptor signaling pathway (GO:1900449)	3.03495220
31	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.98487060
32	neuromuscular process controlling balance (GO:0050885)	2.98344949
33	mannose metabolic process (GO:0006013)	2.98021959
34	postsynaptic membrane organization (GO:0001941)	2.95624385
35	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.87031563
36	regulation of synaptic vesicle transport (GO:1902803)	2.85400991
37	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.81233839
38	L-amino acid import (GO:0043092)	2.80619969
39	axon ensheathment in central nervous system (GO:0032291)	2.79584252
40	central nervous system myelination (GO:0022010)	2.79584252
41	positive regulation of dendritic spine development (GO:0060999)	2.79549285
42	cell communication by electrical coupling (GO:0010644)	2.79132376
43	neuronal action potential propagation (GO:0019227)	2.77084864
44	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.73708270
45	semaphorin-plexin signaling pathway (GO:0071526)	2.71215716
46	cerebellar Purkinje cell differentiation (GO:0021702)	2.69677436
47	amino acid import (GO:0043090)	2.68894916
48	membrane depolarization during action potential (GO:0086010)	2.67580557
49	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.63629519
50	dendritic spine morphogenesis (GO:0060997)	2.62432409
51	positive regulation of membrane potential (GO:0045838)	2.61237790
52	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.61198789
53	cellular sodium ion homeostasis (GO:0006883)	2.59565616
54	positive regulation of dendrite development (GO:1900006)	2.59509635
55	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.58915832
56	layer formation in cerebral cortex (GO:0021819)	2.57619560
57	exploration behavior (GO:0035640)	2.54117623
58	long-term memory (GO:0007616)	2.53828952
59	potassium ion import (GO:0010107)	2.51874468
60	neural tube development (GO:0021915)	2.49845182
61	auditory behavior (GO:0031223)	2.46734418
62	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.44679088
63	cell differentiation in hindbrain (GO:0021533)	2.44544311
64	nephron tubule morphogenesis (GO:0072078)	2.44498801
65	nephron epithelium morphogenesis (GO:0072088)	2.44498801
66	cell-cell junction maintenance (GO:0045217)	2.41444802
67	cell volume homeostasis (GO:0006884)	2.40634267
68	protein localization to synapse (GO:0035418)	2.40101273
69	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.39293972
70	positive regulation of dendrite morphogenesis (GO:0050775)	2.38530390
71	regulation of synaptic plasticity (GO:0048167)	2.38520293
72	negative regulation of erythrocyte differentiation (GO:0045647)	2.38265186
73	potassium ion homeostasis (GO:0055075)	2.36451006
74	activation of protein kinase A activity (GO:0034199)	2.36317583
75	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.36284226
76	synaptic vesicle endocytosis (GO:0048488)	2.35112216
77	neurotransmitter transport (GO:0006836)	2.34075397
78	dopamine receptor signaling pathway (GO:0007212)	2.33849622
79	dendritic spine organization (GO:0097061)	2.32268370
80	synaptic transmission, glutamatergic (GO:0035249)	2.29875693
81	regulation of vesicle fusion (GO:0031338)	2.28933143
82	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.28270916
83	neuromuscular process controlling posture (GO:0050884)	2.26366815
84	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.23889295
85	glucocorticoid receptor signaling pathway (GO:0042921)	2.21963401
86	mating behavior (GO:0007617)	2.20217627
87	positive regulation of Rap GTPase activity (GO:0032854)	2.20040025
88	regulation of dendrite morphogenesis (GO:0048814)	2.18735095
89	regulation of glycogen (starch) synthase activity (GO:2000465)	2.18506992
90	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.17498867
91	cerebellar Purkinje cell layer development (GO:0021680)	2.17140707
92	myelination in peripheral nervous system (GO:0022011)	2.16986182
93	peripheral nervous system axon ensheathment (GO:0032292)	2.16986182
94	camera-type eye morphogenesis (GO:0048593)	2.16857824
95	collecting duct development (GO:0072044)	2.16490323
96	chemosensory behavior (GO:0007635)	2.16456902
97	regulation of postsynaptic membrane potential (GO:0060078)	2.16334301
98	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.16222841
99	gamma-aminobutyric acid transport (GO:0015812)	2.16160093
100	receptor clustering (GO:0043113)	2.15269089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.43106552
2	DROSHA_22980978_ChIP-Seq_HELA_Human	3.42215051
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.12971788
4	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.01692480
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.54343972
6	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.33475362
7	KDM2B_26808549_Chip-Seq_K562_Human	2.28501082
8	LXR_22292898_ChIP-Seq_THP-1_Human	2.19900368
9	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.17001076
10	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.02898636
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.99784765
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.98984858
13	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.94437297
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.90645835
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.90645835
16	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.89935435
17	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.89203706
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.88251083
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.88185551
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85883846
21	KDM2B_26808549_Chip-Seq_DND41_Human	1.84999513
22	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.83429959
23	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.82960276
24	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.80534045
25	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.79003160
26	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.77885824
27	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.76809749
28	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.75596687
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.73726641
30	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.72282823
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.70360272
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.66043527
33	CTCF_27219007_Chip-Seq_Bcells_Human	1.64822059
34	TCF7_22412390_ChIP-Seq_EML_Mouse	1.64179095
35	SMC4_20622854_ChIP-Seq_HELA_Human	1.63974522
36	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.62320846
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61384963
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61188727
39	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58246916
40	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.54472003
41	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.52068764
42	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.50454589
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49627163
44	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.49456116
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.47844286
46	CREB1_26743006_Chip-Seq_LNCaP_Human	1.46082338
47	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.42019036
48	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.41662996
49	P68_20966046_ChIP-Seq_HELA_Human	1.40778737
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40660797
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.40222164
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37831068
53	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.37307886
54	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.36660417
55	RACK7_27058665_Chip-Seq_MCF-7_Human	1.32617912
56	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.32300221
57	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.30756246
58	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.30396443
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29822792
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29648873
61	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.26520760
62	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.26140440
63	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.25832530
64	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.22563956
65	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.22019187
66	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.20937735
67	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.20355858
68	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.19200980
69	OCT4_19829295_ChIP-Seq_ESCs_Human	1.19032628
70	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.17743528
71	MYC_22102868_ChIP-Seq_BL_Human	1.17517441
72	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.17304004
73	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.16233898
74	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.15866863
75	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.14130018
76	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.13026023
77	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.12937126
78	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11407900
79	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.09920351
80	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.08474782
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.07873549
82	TP63_22573176_ChIP-Seq_HFKS_Human	1.07441126
83	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.06537793
84	VDR_21846776_ChIP-Seq_THP-1_Human	1.04736162
85	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.04365024
86	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.02599583
87	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.01485010
88	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.01344784
89	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.01085313
90	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.99605447
91	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.98736193
92	KLF4_19829295_ChIP-Seq_ESCs_Human	0.98465744
93	AR_19668381_ChIP-Seq_PC3_Human	0.98232891
94	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.96134121
95	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.96016577
96	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.95394487
97	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94604231
98	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.92971501
99	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.91329106
100	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.90008294

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	5.18832423
2	MP0004270_analgesia	2.95694019
3	MP0003635_abnormal_synaptic_transmissio	2.90427393
4	MP0005423_abnormal_somatic_nervous	2.75750781
5	MP0003705_abnormal_hypodermis_morpholog	2.61747891
6	MP0005409_darkened_coat_color	2.55716632
7	MP0002249_abnormal_larynx_morphology	2.45601610
8	MP0002064_seizures	2.41482839
9	MP0003880_abnormal_central_pattern	2.40275590
10	MP0002063_abnormal_learning/memory/cond	2.38982069
11	MP0003879_abnormal_hair_cell	2.29874658
12	MP0008569_lethality_at_weaning	2.28135588
13	MP0001348_abnormal_lacrimal_gland	2.16397120
14	MP0001486_abnormal_startle_reflex	2.11978578
15	MP0009780_abnormal_chondrocyte_physiolo	2.04617869
16	MP0002822_catalepsy	1.98355685
17	MP0002734_abnormal_mechanical_nocicepti	1.97848167
18	MP0003172_abnormal_lysosome_physiology	1.93996633
19	MP0003329_amyloid_beta_deposits	1.92837689
20	MP0000566_synostosis	1.92178229
21	MP0002572_abnormal_emotion/affect_behav	1.87183070
22	MP0009745_abnormal_behavioral_response	1.87067003
23	MP0005503_abnormal_tendon_morphology	1.82502621
24	MP0003123_paternal_imprinting	1.76743197
25	MP0002272_abnormal_nervous_system	1.75444561
26	MP0009046_muscle_twitch	1.72257044
27	MP0001501_abnormal_sleep_pattern	1.72155483
28	MP0008438_abnormal_cutaneous_collagen	1.69710211
29	MP0001502_abnormal_circadian_rhythm	1.58958410
30	MP0002735_abnormal_chemical_nociception	1.57843819
31	MP0003279_aneurysm	1.55197996
32	MP0003122_maternal_imprinting	1.50062760
33	MP0005670_abnormal_white_adipose	1.48698290
34	MP0005377_hearing/vestibular/ear_phenot	1.46018850
35	MP0003878_abnormal_ear_physiology	1.46018850
36	MP0000751_myopathy	1.45726415
37	MP0005076_abnormal_cell_differentiation	1.39521712
38	MP0002557_abnormal_social/conspecific_i	1.38829390
39	MP0003045_fibrosis	1.34941032
40	MP0003690_abnormal_glial_cell	1.34523992
41	MP0000955_abnormal_spinal_cord	1.33053297
42	MP0002089_abnormal_postnatal_growth/wei	1.32917379
43	MP0000778_abnormal_nervous_system	1.30924564
44	MP0002067_abnormal_sensory_capabilities	1.26441884
45	MP0001970_abnormal_pain_threshold	1.25686050
46	MP0001968_abnormal_touch/_nociception	1.23391271
47	MP0001958_emphysema	1.22211163
48	MP0002733_abnormal_thermal_nociception	1.21831590
49	MP0002882_abnormal_neuron_morphology	1.19396129
50	MP0003634_abnormal_glial_cell	1.18879635
51	MP0004811_abnormal_neuron_physiology	1.18856783
52	MP0000003_abnormal_adipose_tissue	1.18340316
53	MP0001849_ear_inflammation	1.18212591
54	MP0009384_cardiac_valve_regurgitation	1.17309626
55	MP0002108_abnormal_muscle_morphology	1.13830290
56	MP0002184_abnormal_innervation	1.12730032
57	MP0002066_abnormal_motor_capabilities/c	1.11969350
58	MP0000920_abnormal_myelination	1.08592647
59	MP0000678_abnormal_parathyroid_gland	1.08078692
60	MP0004858_abnormal_nervous_system	1.07774405
61	MP0004130_abnormal_muscle_cell	1.06574448
62	MP0003633_abnormal_nervous_system	1.03616784
63	MP0002152_abnormal_brain_morphology	1.03189446
64	MP0004885_abnormal_endolymph	1.02265654
65	MP0003631_nervous_system_phenotype	1.00949937
66	MP0003283_abnormal_digestive_organ	1.00141397
67	MP0009278_abnormal_bone_marrow	0.99922019
68	MP0004742_abnormal_vestibular_system	0.99152346
69	MP0001299_abnormal_eye_distance/	0.99095159
70	MP0004043_abnormal_pH_regulation	0.98982726
71	MP0003632_abnormal_nervous_system	0.97806944
72	MP0001270_distended_abdomen	0.95292569
73	MP0003787_abnormal_imprinting	0.94990360
74	MP0003115_abnormal_respiratory_system	0.93775483
75	MP0001440_abnormal_grooming_behavior	0.91641251
76	MP0005375_adipose_tissue_phenotype	0.89643966
77	MP0000534_abnormal_ureter_morphology	0.88749666
78	MP0005386_behavior/neurological_phenoty	0.88277962
79	MP0004924_abnormal_behavior	0.88277962
80	MP0005666_abnormal_adipose_tissue	0.86660972
81	MP0001485_abnormal_pinna_reflex	0.85098722
82	MP0002116_abnormal_craniofacial_bone	0.84457205
83	MP0005646_abnormal_pituitary_gland	0.83810571
84	MP0001177_atelectasis	0.83118501
85	MP0000733_abnormal_muscle_development	0.82972327
86	MP0003861_abnormal_nervous_system	0.82442943
87	MP0001963_abnormal_hearing_physiology	0.82162349
88	MP0000747_muscle_weakness	0.81274564
89	MP0003942_abnormal_urinary_system	0.80418123
90	MP0002229_neurodegeneration	0.78644514
91	MP0000579_abnormal_nail_morphology	0.77367079
92	MP0004145_abnormal_muscle_electrophysio	0.74089559
93	MP0003091_abnormal_cell_migration	0.73905921
94	MP0002932_abnormal_joint_morphology	0.72344676
95	MP0001943_abnormal_respiration	0.70373179
96	MP0005508_abnormal_skeleton_morphology	0.69602061
97	MP0005275_abnormal_skin_tensile	0.69559788
98	MP0010769_abnormal_survival	0.68272693
99	MP0002114_abnormal_axial_skeleton	0.68055125
100	MP0001984_abnormal_olfaction	0.67918843

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	5.10126512
2	Cerebral aneurysm (HP:0004944)	4.04943640
3	Hyperacusis (HP:0010780)	3.12042190
4	Myokymia (HP:0002411)	2.96121372
5	Shallow orbits (HP:0000586)	2.95190321
6	Focal seizures (HP:0007359)	2.89220092
7	Genetic anticipation (HP:0003743)	2.88112282
8	Bronchomalacia (HP:0002780)	2.85525366
9	Epileptic encephalopathy (HP:0200134)	2.81216197
10	Supranuclear gaze palsy (HP:0000605)	2.80889599
11	Focal motor seizures (HP:0011153)	2.77244162
12	Abnormality of binocular vision (HP:0011514)	2.74806403
13	Diplopia (HP:0000651)	2.74806403
14	Progressive cerebellar ataxia (HP:0002073)	2.73562701
15	Broad metatarsal (HP:0001783)	2.73236794
16	Protrusio acetabuli (HP:0003179)	2.70355658
17	Ankle clonus (HP:0011448)	2.61446078
18	Abnormality of the fingertips (HP:0001211)	2.58134330
19	Renovascular hypertension (HP:0100817)	2.56344188
20	Neurofibrillary tangles (HP:0002185)	2.56048959
21	Febrile seizures (HP:0002373)	2.53523045
22	Broad face (HP:0000283)	2.53381923
23	Annular pancreas (HP:0001734)	2.43541725
24	Distal upper limb amyotrophy (HP:0007149)	2.43539487
25	Upper limb amyotrophy (HP:0009129)	2.43539487
26	Turricephaly (HP:0000262)	2.37144910
27	Insomnia (HP:0100785)	2.33489617
28	Papilledema (HP:0001085)	2.28993325
29	Sleep apnea (HP:0010535)	2.28101247
30	Action tremor (HP:0002345)	2.21584368
31	Bell-shaped thorax (HP:0001591)	2.21379094
32	Bowel diverticulosis (HP:0005222)	2.20077686
33	Atonic seizures (HP:0010819)	2.15527917
34	Dysmetric saccades (HP:0000641)	2.14958512
35	Pointed chin (HP:0000307)	2.13897658
36	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.10758355
37	Macroorchidism (HP:0000053)	2.10687487
38	Hand muscle atrophy (HP:0009130)	2.10529963
39	Thin bony cortex (HP:0002753)	2.08434364
40	Neoplasm of the heart (HP:0100544)	2.08203258
41	Hypoplastic ischia (HP:0003175)	2.03809045
42	Hyperkalemia (HP:0002153)	2.03172793
43	Abnormality of the aortic arch (HP:0012303)	2.02989342
44	Stereotypic behavior (HP:0000733)	2.02858892
45	Aneurysm (HP:0002617)	2.01141818
46	Postural instability (HP:0002172)	2.00875587
47	Bladder diverticulum (HP:0000015)	2.00194124
48	Truncal ataxia (HP:0002078)	1.99408363
49	Visual hallucinations (HP:0002367)	1.99220032
50	Cerebral inclusion bodies (HP:0100314)	1.98775636
51	Atelectasis (HP:0100750)	1.96321349
52	Impaired smooth pursuit (HP:0007772)	1.95435765
53	Mild short stature (HP:0003502)	1.92654237
54	Heterotopia (HP:0002282)	1.90081368
55	Torticollis (HP:0000473)	1.89915127
56	Vertebral arch anomaly (HP:0008438)	1.87953942
57	Precocious puberty (HP:0000826)	1.87335113
58	Stridor (HP:0010307)	1.83260247
59	Abnormality of the ischium (HP:0003174)	1.82840376
60	Long eyelashes (HP:0000527)	1.82519943
61	Renal duplication (HP:0000075)	1.82188191
62	Urinary bladder sphincter dysfunction (HP:0002839)	1.81165363
63	Mitral regurgitation (HP:0001653)	1.80808037
64	Spinal canal stenosis (HP:0003416)	1.80474815
65	Mitral valve prolapse (HP:0001634)	1.80467589
66	Broad palm (HP:0001169)	1.80264838
67	Elfin facies (HP:0004428)	1.79624726
68	Biconcave vertebral bodies (HP:0004586)	1.79019013
69	Narrow palate (HP:0000189)	1.78563672
70	Tracheomalacia (HP:0002779)	1.77340015
71	Abnormality of dentin (HP:0010299)	1.77069060
72	Ulnar bowing (HP:0003031)	1.75119267
73	Neonatal short-limb short stature (HP:0008921)	1.74991192
74	Abnormality of ocular smooth pursuit (HP:0000617)	1.74528038
75	Spastic gait (HP:0002064)	1.74500736
76	Lymphangioma (HP:0100764)	1.73874072
77	Flat cornea (HP:0007720)	1.72717642
78	Thin ribs (HP:0000883)	1.70636562
79	Dislocated radial head (HP:0003083)	1.70590112
80	Aortic aneurysm (HP:0004942)	1.70280528
81	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.69523672
82	Akinesia (HP:0002304)	1.69143511
83	Trigonocephaly (HP:0000243)	1.68500491
84	Laryngomalacia (HP:0001601)	1.64855407
85	Onion bulb formation (HP:0003383)	1.64350088
86	Status epilepticus (HP:0002133)	1.64316629
87	Overgrowth (HP:0001548)	1.64032284
88	Neuronal loss in central nervous system (HP:0002529)	1.63637466
89	Deep venous thrombosis (HP:0002625)	1.63619217
90	Aortic dissection (HP:0002647)	1.60963645
91	Abnormality of the lower motor neuron (HP:0002366)	1.60309477
92	Abnormality of the radial head (HP:0003995)	1.59958488
93	Supernumerary ribs (HP:0005815)	1.59884420
94	Depression (HP:0000716)	1.59732079
95	Truncal obesity (HP:0001956)	1.59314711
96	Atrophic scars (HP:0001075)	1.58411385
97	Overriding aorta (HP:0002623)	1.57813099
98	Obsessive-compulsive behavior (HP:0000722)	1.57189480
99	Mask-like facies (HP:0000298)	1.57130000
100	Disproportionate tall stature (HP:0001519)	1.56685119

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.87557621
2	CDK12	2.49543360
3	NTRK3	2.47404852
4	EEF2K	2.32107278
5	TYRO3	2.24711563
6	SIK2	2.24277653
7	RIPK1	2.24096960
8	PRKD3	2.16537442
9	ICK	2.15633005
10	CAMKK1	2.03955075
11	FGFR4	2.03611546
12	MARK2	1.97200925
13	MARK1	1.94611068
14	PRPF4B	1.89891663
15	NTRK2	1.78925415
16	FGFR2	1.72242223
17	WNK1	1.68051548
18	EPHA4	1.66349097
19	CAMK1G	1.64146499
20	UHMK1	1.62131335
21	SIK1	1.60934946
22	PDGFRA	1.54209488
23	MAP3K13	1.49409156
24	DAPK2	1.48906777
25	PAK6	1.44838267
26	MAP3K7	1.43781244
27	MAPK15	1.34776000
28	PRKCH	1.33321297
29	CDC42BPA	1.33265403
30	FGFR3	1.29475104
31	DDR2	1.25588215
32	PKN2	1.23789053
33	WNK4	1.23073591
34	CAMK1D	1.21534510
35	INSRR	1.21259092
36	MAP3K9	1.19689388
37	NTRK1	1.14570212
38	TNK2	1.12849698
39	MTOR	1.11168238
40	CAMK1	1.11123069
41	KSR2	1.09792854
42	ERN1	1.09579676
43	SGK494	1.07132221
44	SGK223	1.07132221
45	LATS2	1.05941808
46	STK38	1.04396691
47	BRD4	1.02718983
48	SMG1	1.01720639
49	RET	0.98740361
50	MAPK12	0.95953866
51	MAP3K10	0.92709751
52	PNCK	0.92664090
53	PDPK1	0.90819015
54	SGK3	0.90293394
55	RPS6KA2	0.88995085
56	SGK2	0.83586575
57	SGK1	0.81310316
58	PDGFRB	0.80852161
59	PRKD2	0.79981281
60	CDK5	0.79884001
61	PDK1	0.76895952
62	CAMK4	0.75797736
63	MAPK10	0.73335557
64	ERBB2	0.70796603
65	STK11	0.70069225
66	MAP2K6	0.69535559
67	HIPK2	0.68524412
68	NEK6	0.68505241
69	BMX	0.67457028
70	MAPK11	0.67135892
71	AKT3	0.65853638
72	DYRK1A	0.60053464
73	MET	0.59115670
74	PRKAA1	0.57312662
75	MINK1	0.56699504
76	CASK	0.56607819
77	PHKG2	0.55146971
78	PHKG1	0.55146971
79	MAPK8	0.54766747
80	MAP3K6	0.54651049
81	TTN	0.54535915
82	MAPK7	0.51783359
83	RIPK4	0.49717006
84	MAPK13	0.49196465
85	TAOK1	0.49009936
86	RPS6KA3	0.48702867
87	MAP2K2	0.48465107
88	MST1R	0.47724060
89	PTK2	0.45922455
90	RPS6KL1	0.45273252
91	RPS6KC1	0.45273252
92	GSK3B	0.44447094
93	MAP3K2	0.44137898
94	DYRK1B	0.41685291
95	PTK6	0.41458500
96	PRKCZ	0.41273055
97	PRKAA2	0.40926230
98	MAP3K1	0.40612345
99	TRPM7	0.40601324
100	RPS6KA6	0.40524113

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Long-term potentiation_Homo sapiens_hsa04720	2.14613285
2	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.86278832
3	Nicotine addiction_Homo sapiens_hsa05033	1.85762756
4	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.84033440
5	Insulin secretion_Homo sapiens_hsa04911	1.75848117
6	Glutamatergic synapse_Homo sapiens_hsa04724	1.75619632
7	Circadian entrainment_Homo sapiens_hsa04713	1.69340637
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.68083407
9	Amphetamine addiction_Homo sapiens_hsa05031	1.56232944
10	GnRH signaling pathway_Homo sapiens_hsa04912	1.53448255
11	Notch signaling pathway_Homo sapiens_hsa04330	1.52230945
12	Gastric acid secretion_Homo sapiens_hsa04971	1.50855502
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.48653936
14	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.47434349
15	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.46550982
16	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.45627646
17	GABAergic synapse_Homo sapiens_hsa04727	1.41169837
18	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.40747333
19	Estrogen signaling pathway_Homo sapiens_hsa04915	1.39823656
20	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.39419678
21	Cholinergic synapse_Homo sapiens_hsa04725	1.38839019
22	VEGF signaling pathway_Homo sapiens_hsa04370	1.37960002
23	Morphine addiction_Homo sapiens_hsa05032	1.37178046
24	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.34127451
25	Cocaine addiction_Homo sapiens_hsa05030	1.33078340
26	Choline metabolism in cancer_Homo sapiens_hsa05231	1.32472215
27	Glioma_Homo sapiens_hsa05214	1.30729015
28	ErbB signaling pathway_Homo sapiens_hsa04012	1.28957943
29	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.28772505
30	Salivary secretion_Homo sapiens_hsa04970	1.27643086
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.21699311
32	mTOR signaling pathway_Homo sapiens_hsa04150	1.16297282
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.15711100
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.15470860
35	Lysine degradation_Homo sapiens_hsa00310	1.15183819
36	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.14761466
37	cAMP signaling pathway_Homo sapiens_hsa04024	1.14046790
38	Renin secretion_Homo sapiens_hsa04924	1.12602692
39	Melanogenesis_Homo sapiens_hsa04916	1.11295880
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10475878
41	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.10222126
42	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.09167868
43	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.08904835
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.07495066
45	Type II diabetes mellitus_Homo sapiens_hsa04930	1.05746545
46	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.04247002
47	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.03551014
48	Long-term depression_Homo sapiens_hsa04730	1.03496761
49	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.03241273
50	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.01076941
51	Taste transduction_Homo sapiens_hsa04742	1.00786266
52	Non-small cell lung cancer_Homo sapiens_hsa05223	0.99630159
53	Other glycan degradation_Homo sapiens_hsa00511	0.98656516
54	ABC transporters_Homo sapiens_hsa02010	0.98336538
55	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.98080652
56	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.98005195
57	Bile secretion_Homo sapiens_hsa04976	0.96768334
58	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.95428050
59	Axon guidance_Homo sapiens_hsa04360	0.95033153
60	Endometrial cancer_Homo sapiens_hsa05213	0.94764080
61	ECM-receptor interaction_Homo sapiens_hsa04512	0.93347112
62	Acute myeloid leukemia_Homo sapiens_hsa05221	0.93161771
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.91423526
64	Glucagon signaling pathway_Homo sapiens_hsa04922	0.89940880
65	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.88722243
66	Insulin signaling pathway_Homo sapiens_hsa04910	0.86948268
67	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.86288487
68	Prion diseases_Homo sapiens_hsa05020	0.82979738
69	Gap junction_Homo sapiens_hsa04540	0.82633809
70	Focal adhesion_Homo sapiens_hsa04510	0.80947025
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.78279441
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.76232360
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75347239
74	Protein digestion and absorption_Homo sapiens_hsa04974	0.73444223
75	Pancreatic secretion_Homo sapiens_hsa04972	0.72776284
76	Renal cell carcinoma_Homo sapiens_hsa05211	0.72355278
77	Rap1 signaling pathway_Homo sapiens_hsa04015	0.70681034
78	Prolactin signaling pathway_Homo sapiens_hsa04917	0.69510781
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.69347822
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.69287412
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68331238
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.66344732
83	Ras signaling pathway_Homo sapiens_hsa04014	0.65032619
84	Serotonergic synapse_Homo sapiens_hsa04726	0.64880552
85	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.63932181
86	Insulin resistance_Homo sapiens_hsa04931	0.62285025
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59256496
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59039173
89	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57872725
90	Amoebiasis_Homo sapiens_hsa05146	0.57298039
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56610803
92	Histidine metabolism_Homo sapiens_hsa00340	0.56398718
93	Prostate cancer_Homo sapiens_hsa05215	0.56115974
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.55359177
95	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.55236782
96	Olfactory transduction_Homo sapiens_hsa04740	0.55022934
97	Adherens junction_Homo sapiens_hsa04520	0.53497530
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53210114
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.53143874
100	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.52064059

NPIPA1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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