ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	6.37517326
2	protein K11-linked deubiquitination (GO:0035871)	6.26982156
3	sperm motility (GO:0030317)	6.02095081
4	single strand break repair (GO:0000012)	5.38174233
5	fusion of sperm to egg plasma membrane (GO:0007342)	4.88582933
6	organic cation transport (GO:0015695)	4.80571180
7	establishment of protein localization to Golgi (GO:0072600)	4.69289709
8	piRNA metabolic process (GO:0034587)	4.68877259
9	response to pheromone (GO:0019236)	4.67565566
10	microtubule depolymerization (GO:0007019)	4.65874256
11	spermatid development (GO:0007286)	4.65551718
12	seminiferous tubule development (GO:0072520)	4.58710084
13	protein polyglutamylation (GO:0018095)	4.52190253
14	regulation of centriole replication (GO:0046599)	4.49242685
15	regulation of meiosis I (GO:0060631)	4.36812286
16	microtubule polymerization or depolymerization (GO:0031109)	4.36018794
17	centriole replication (GO:0007099)	4.35633581
18	protein targeting to Golgi (GO:0000042)	4.29165567
19	DNA double-strand break processing (GO:0000729)	4.23994506
20	serotonin receptor signaling pathway (GO:0007210)	4.19819350
21	rRNA methylation (GO:0031167)	4.15804009
22	rRNA modification (GO:0000154)	4.15498275
23	sperm-egg recognition (GO:0035036)	3.91340729
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.75589965
25	plasma membrane fusion (GO:0045026)	3.67859209
26	regulation of cilium movement (GO:0003352)	3.65976607
27	centriole assembly (GO:0098534)	3.58203472
28	regulation of appetite (GO:0032098)	3.57334037
29	coenzyme catabolic process (GO:0009109)	3.56190283
30	binding of sperm to zona pellucida (GO:0007339)	3.49544750
31	hematopoietic stem cell proliferation (GO:0071425)	3.49338694
32	synapsis (GO:0007129)	3.48833463
33	chromosome condensation (GO:0030261)	3.43422005
34	replication fork processing (GO:0031297)	3.42247658
35	sperm capacitation (GO:0048240)	3.40518696
36	protein sumoylation (GO:0016925)	3.39609401
37	DNA packaging (GO:0006323)	3.39135004
38	spermatogenesis (GO:0007283)	3.37801093
39	male gamete generation (GO:0048232)	3.37309240
40	cilium or flagellum-dependent cell motility (GO:0001539)	3.35238652
41	cellular ketone body metabolic process (GO:0046950)	3.32734085
42	male meiosis (GO:0007140)	3.30961027
43	negative regulation of interleukin-8 production (GO:0032717)	3.26395487
44	protein localization to Golgi apparatus (GO:0034067)	3.23161633
45	calcium ion-dependent exocytosis (GO:0017156)	3.20669641
46	spermatid nucleus differentiation (GO:0007289)	3.16432624
47	multicellular organism reproduction (GO:0032504)	3.15245603
48	negative regulation of circadian rhythm (GO:0042754)	3.15041732
49	gamete generation (GO:0007276)	3.12622914
50	ketone body metabolic process (GO:1902224)	3.10084702
51	cell-cell recognition (GO:0009988)	3.04781886
52	axonemal dynein complex assembly (GO:0070286)	3.02106516
53	sulfation (GO:0051923)	2.99950544
54	DNA methylation involved in gamete generation (GO:0043046)	2.98334989
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97330969
56	carnitine transmembrane transport (GO:1902603)	2.97305342
57	single fertilization (GO:0007338)	2.95827307
58	germ cell development (GO:0007281)	2.95748837
59	glycerol ether metabolic process (GO:0006662)	2.94108234
60	negative regulation of metanephros development (GO:0072217)	2.93356152
61	resolution of meiotic recombination intermediates (GO:0000712)	2.91789967
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89834560
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.87694859
64	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86403187
65	male meiosis I (GO:0007141)	2.86230275
66	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.84935080
67	meiotic cell cycle (GO:0051321)	2.84760702
68	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.82718700
69	lymphangiogenesis (GO:0001946)	2.82546487
70	epithelial cilium movement (GO:0003351)	2.81527771
71	protein-cofactor linkage (GO:0018065)	2.81453885
72	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.81097362
73	regulation of penile erection (GO:0060405)	2.81057101
74	ether metabolic process (GO:0018904)	2.74107239
75	histone exchange (GO:0043486)	2.74081373
76	positive regulation of digestive system process (GO:0060456)	2.67866235
77	amino-acid betaine transport (GO:0015838)	2.66921253
78	carnitine transport (GO:0015879)	2.66921253
79	intra-S DNA damage checkpoint (GO:0031573)	2.64454935
80	cysteine metabolic process (GO:0006534)	2.64237198
81	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.59891217
82	detection of light stimulus involved in visual perception (GO:0050908)	2.58656171
83	detection of light stimulus involved in sensory perception (GO:0050962)	2.58656171
84	DNA integration (GO:0015074)	2.58585559
85	fertilization (GO:0009566)	2.58138921
86	motile cilium assembly (GO:0044458)	2.57924149
87	reproduction (GO:0000003)	2.56402403
88	regulation of sarcomere organization (GO:0060297)	2.55657768
89	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.55015629
90	indole-containing compound catabolic process (GO:0042436)	2.54920137
91	indolalkylamine catabolic process (GO:0046218)	2.54920137
92	tryptophan catabolic process (GO:0006569)	2.54920137
93	gene silencing by RNA (GO:0031047)	2.54837668
94	regulation of Cdc42 GTPase activity (GO:0043088)	2.54311243
95	nephron epithelium morphogenesis (GO:0072088)	2.53669481
96	nephron tubule morphogenesis (GO:0072078)	2.53669481
97	histone mRNA catabolic process (GO:0071044)	2.53382308
98	sex differentiation (GO:0007548)	2.53203656
99	proteasome assembly (GO:0043248)	2.49986798
100	mannosylation (GO:0097502)	2.49036289

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62953934
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.44789809
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.14273996
4	FUS_26573619_Chip-Seq_HEK293_Human	2.94370479
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.57006162
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55659811
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.54699191
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51328440
9	CBP_20019798_ChIP-Seq_JUKART_Human	2.20177267
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.20177267
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19069606
12	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.14172945
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.08678472
14	VDR_22108803_ChIP-Seq_LS180_Human	2.08566261
15	P300_19829295_ChIP-Seq_ESCs_Human	2.08533771
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03058807
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.02257773
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.00645246
19	EWS_26573619_Chip-Seq_HEK293_Human	2.00593729
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.94650262
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93115763
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92466743
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.90998904
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88899754
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84737134
26	AR_25329375_ChIP-Seq_VCAP_Human	1.74558488
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.72321332
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71982492
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68168870
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57607721
31	E2F7_22180533_ChIP-Seq_HELA_Human	1.57340992
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56032776
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.55334006
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48724380
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.47632532
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.46558757
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44610495
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42127883
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42127883
40	STAT3_23295773_ChIP-Seq_U87_Human	1.41069133
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.40093073
42	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.39024603
43	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.37608872
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36898661
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.35508861
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34083267
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32372943
48	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29834783
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28689358
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28362829
51	PHF8_20622853_ChIP-Seq_HELA_Human	1.28063008
52	TCF4_23295773_ChIP-Seq_U87_Human	1.27732792
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26882583
54	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26801595
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.26326620
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24563006
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24563006
58	ERG_20517297_ChIP-Seq_VCAP_Human	1.23212497
59	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.21477500
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21474605
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18987370
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18987370
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18911462
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18677738
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.18341912
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18230626
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.17626649
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.15739395
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15081861
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14244798
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13975896
72	ERA_21632823_ChIP-Seq_H3396_Human	1.12154360
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11451832
74	NFYB_21822215_ChIP-Seq_K562_Human	1.10567582
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10209791
76	NCOR_22424771_ChIP-Seq_293T_Human	1.07292177
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07235845
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.07138421
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06990854
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.06990845
81	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.05849320
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05707900
83	ETV1_20927104_ChIP-Seq_GIST48_Human	1.05541822
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05467654
85	TBL1_22424771_ChIP-Seq_293T_Human	1.05419519
86	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05239117
87	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04613513
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.04407623
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03354425
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03185690
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03114134
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02255771
93	JUN_21703547_ChIP-Seq_K562_Human	1.02132456
94	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00736826
95	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.00432289
96	AR_20517297_ChIP-Seq_VCAP_Human	1.00313036
97	BCAT_22108803_ChIP-Seq_LS180_Human	1.00083652
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99494489
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99060470
100	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.98795277

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.78437690
2	MP0002254_reproductive_system_inflammat	3.47577943
3	MP0005084_abnormal_gallbladder_morpholo	2.82491599
4	MP0005670_abnormal_white_adipose	2.77436529
5	MP0001529_abnormal_vocalization	2.71906879
6	MP0002138_abnormal_hepatobiliary_system	2.65113197
7	MP0003718_maternal_effect	2.63497124
8	MP0005377_hearing/vestibular/ear_phenot	2.62197683
9	MP0003878_abnormal_ear_physiology	2.62197683
10	MP0003806_abnormal_nucleotide_metabolis	2.53474285
11	MP0001984_abnormal_olfaction	2.52844465
12	MP0003698_abnormal_male_reproductive	2.41237527
13	MP0008058_abnormal_DNA_repair	2.40673575
14	MP0008877_abnormal_DNA_methylation	2.33778383
15	MP0001929_abnormal_gametogenesis	2.27230358
16	MP0002735_abnormal_chemical_nociception	2.13331152
17	MP0000372_irregular_coat_pigmentation	2.02289439
18	MP0001968_abnormal_touch/_nociception	1.90588452
19	MP0003646_muscle_fatigue	1.89835804
20	MP0002736_abnormal_nociception_after	1.84663015
21	MP0002102_abnormal_ear_morphology	1.84179397
22	MP0006276_abnormal_autonomic_nervous	1.81344732
23	MP0003183_abnormal_peptide_metabolism	1.77549646
24	MP0004957_abnormal_blastocyst_morpholog	1.74483442
25	MP0005551_abnormal_eye_electrophysiolog	1.66451835
26	MP0002210_abnormal_sex_determination	1.66234969
27	MP0005310_abnormal_salivary_gland	1.57096780
28	MP0010094_abnormal_chromosome_stability	1.56760167
29	MP0002822_catalepsy	1.51652702
30	MP0009697_abnormal_copulation	1.44169864
31	MP0008875_abnormal_xenobiotic_pharmacok	1.39668625
32	MP0001145_abnormal_male_reproductive	1.39381272
33	MP0006292_abnormal_olfactory_placode	1.36860941
34	MP0005083_abnormal_biliary_tract	1.36481790
35	MP0001486_abnormal_startle_reflex	1.36121740
36	MP0008995_early_reproductive_senescence	1.35887785
37	MP0000653_abnormal_sex_gland	1.33562845
38	MP0002161_abnormal_fertility/fecundity	1.30522114
39	MP0009745_abnormal_behavioral_response	1.27210697
40	MP0003880_abnormal_central_pattern	1.26012502
41	MP0001348_abnormal_lacrimal_gland	1.25259526
42	MP0009046_muscle_twitch	1.22596492
43	MP0005253_abnormal_eye_physiology	1.17541782
44	MP0001485_abnormal_pinna_reflex	1.17473571
45	MP0000613_abnormal_salivary_gland	1.15694975
46	MP0002938_white_spotting	1.14290581
47	MP0003136_yellow_coat_color	1.13352651
48	MP0003693_abnormal_embryo_hatching	1.08923435
49	MP0003567_abnormal_fetal_cardiomyocyte	1.06114309
50	MP0002572_abnormal_emotion/affect_behav	1.05857298
51	MP0005389_reproductive_system_phenotype	1.05320075
52	MP0000383_abnormal_hair_follicle	1.03117083
53	MP0003011_delayed_dark_adaptation	1.00749693
54	MP0005187_abnormal_penis_morphology	0.99999183
55	MP0001293_anophthalmia	0.99247552
56	MP0002734_abnormal_mechanical_nocicepti	0.97633040
57	MP0002272_abnormal_nervous_system	0.96147330
58	MP0002160_abnormal_reproductive_system	0.95466117
59	MP0003077_abnormal_cell_cycle	0.93853389
60	MP0001970_abnormal_pain_threshold	0.93156875
61	MP0006035_abnormal_mitochondrial_morpho	0.92811230
62	MP0001919_abnormal_reproductive_system	0.92154575
63	MP0001905_abnormal_dopamine_level	0.91023498
64	MP0000230_abnormal_systemic_arterial	0.89968466
65	MP0000516_abnormal_urinary_system	0.89310181
66	MP0005367_renal/urinary_system_phenotyp	0.89310181
67	MP0000049_abnormal_middle_ear	0.88642730
68	MP0002928_abnormal_bile_duct	0.86590072
69	MP0000569_abnormal_digit_pigmentation	0.85732807
70	MP0008872_abnormal_physiological_respon	0.85582891
71	MP0004142_abnormal_muscle_tone	0.84783565
72	MP0002127_abnormal_cardiovascular_syste	0.83379315
73	MP0003195_calcinosis	0.82782133
74	MP0002837_dystrophic_cardiac_calcinosis	0.82651011
75	MP0001324_abnormal_eye_pigmentation	0.82303891
76	MP0005395_other_phenotype	0.82278984
77	MP0001764_abnormal_homeostasis	0.81976866
78	MP0000631_abnormal_neuroendocrine_gland	0.79986806
79	MP0002733_abnormal_thermal_nociception	0.76814670
80	MP0002229_neurodegeneration	0.75202151
81	MP0001986_abnormal_taste_sensitivity	0.74728761
82	MP0004085_abnormal_heartbeat	0.73765849
83	MP0002067_abnormal_sensory_capabilities	0.73032209
84	MP0006072_abnormal_retinal_apoptosis	0.72734800
85	MP0002095_abnormal_skin_pigmentation	0.71003456
86	MP0008789_abnormal_olfactory_epithelium	0.70720167
87	MP0006036_abnormal_mitochondrial_physio	0.70575891
88	MP0005423_abnormal_somatic_nervous	0.70178647
89	MP0002064_seizures	0.70163123
90	MP0003936_abnormal_reproductive_system	0.68678351
91	MP0002557_abnormal_social/conspecific_i	0.68138408
92	MP0002234_abnormal_pharynx_morphology	0.68004785
93	MP0008932_abnormal_embryonic_tissue	0.67462135
94	MP0005174_abnormal_tail_pigmentation	0.66741891
95	MP0001879_abnormal_lymphatic_vessel	0.66689266
96	MP0004484_altered_response_of	0.66520107
97	MP0003137_abnormal_impulse_conducting	0.66234282
98	MP0002876_abnormal_thyroid_physiology	0.65653509
99	MP0003252_abnormal_bile_duct	0.65538780
100	MP0005647_abnormal_sex_gland	0.65219615

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.05122459
2	Tubulointerstitial nephritis (HP:0001970)	3.99523165
3	True hermaphroditism (HP:0010459)	3.58436328
4	Chronic hepatic failure (HP:0100626)	3.51440226
5	Nephronophthisis (HP:0000090)	3.36087549
6	Pancreatic cysts (HP:0001737)	3.31414193
7	Abolished electroretinogram (ERG) (HP:0000550)	3.31061968
8	Bony spicule pigmentary retinopathy (HP:0007737)	3.24313841
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.22906305
10	Absent/shortened dynein arms (HP:0200106)	3.22906305
11	Hyperglycinuria (HP:0003108)	3.16412360
12	Hyperglycinemia (HP:0002154)	3.14918787
13	Pancreatic fibrosis (HP:0100732)	3.12045078
14	Aplasia/hypoplasia of the uterus (HP:0008684)	2.84178067
15	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.82680207
16	Abnormality of the renal medulla (HP:0100957)	2.67863260
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.63961560
18	Lower limb hyperreflexia (HP:0002395)	2.61406532
19	Severe visual impairment (HP:0001141)	2.57027203
20	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.54634403
21	Stage 5 chronic kidney disease (HP:0003774)	2.49952206
22	Hypoplasia of the uterus (HP:0000013)	2.48844339
23	Male pseudohermaphroditism (HP:0000037)	2.45746755
24	Abnormality of glycine metabolism (HP:0010895)	2.44872035
25	Abnormality of serine family amino acid metabolism (HP:0010894)	2.44872035
26	Abnormal respiratory epithelium morphology (HP:0012253)	2.42322634
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42322634
28	Acute encephalopathy (HP:0006846)	2.40664336
29	Volvulus (HP:0002580)	2.40376521
30	Colon cancer (HP:0003003)	2.38793981
31	Abnormal ciliary motility (HP:0012262)	2.30070064
32	Abnormality of the ileum (HP:0001549)	2.29996057
33	Congenital sensorineural hearing impairment (HP:0008527)	2.28701435
34	Retinal dysplasia (HP:0007973)	2.25771393
35	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25251472
36	Bilateral microphthalmos (HP:0007633)	2.20728409
37	Glycosuria (HP:0003076)	2.19147807
38	Abnormality of urine glucose concentration (HP:0011016)	2.19147807
39	Meckel diverticulum (HP:0002245)	2.18470743
40	Small hand (HP:0200055)	2.18018745
41	Medial flaring of the eyebrow (HP:0010747)	2.17272106
42	Abnormal lung lobation (HP:0002101)	2.15417041
43	Intestinal atresia (HP:0011100)	2.14609565
44	Acute necrotizing encephalopathy (HP:0006965)	2.10526907
45	Molar tooth sign on MRI (HP:0002419)	2.10362828
46	Abnormality of midbrain morphology (HP:0002418)	2.10362828
47	Occipital encephalocele (HP:0002085)	2.10008913
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08858601
49	Ependymoma (HP:0002888)	2.06159750
50	Congenital stationary night blindness (HP:0007642)	2.02389043
51	Cerebellar dysplasia (HP:0007033)	2.00281511
52	Abnormality of the labia minora (HP:0012880)	1.98464741
53	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97487183
54	Abnormal protein N-linked glycosylation (HP:0012347)	1.97487183
55	Abnormal protein glycosylation (HP:0012346)	1.97487183
56	Abnormal glycosylation (HP:0012345)	1.97487183
57	Unilateral renal agenesis (HP:0000122)	1.97389587
58	Nephrogenic diabetes insipidus (HP:0009806)	1.97007188
59	Polydipsia (HP:0001959)	1.96578764
60	Abnormal drinking behavior (HP:0030082)	1.96578764
61	Abnormality of macular pigmentation (HP:0008002)	1.95924606
62	Genital tract atresia (HP:0001827)	1.94485849
63	Abnormality of serum amino acid levels (HP:0003112)	1.94233786
64	Hepatocellular necrosis (HP:0001404)	1.93228541
65	Postaxial foot polydactyly (HP:0001830)	1.92896515
66	Cystic liver disease (HP:0006706)	1.91275912
67	Sloping forehead (HP:0000340)	1.91022635
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90376746
69	Gastrointestinal atresia (HP:0002589)	1.90249377
70	Hyperkalemia (HP:0002153)	1.89059424
71	Gait imbalance (HP:0002141)	1.88990220
72	Impulsivity (HP:0100710)	1.88566653
73	Congenital primary aphakia (HP:0007707)	1.88276549
74	Absent speech (HP:0001344)	1.85589822
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85101270
76	Hyperventilation (HP:0002883)	1.85012354
77	Glioma (HP:0009733)	1.84287039
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84074227
79	Duodenal stenosis (HP:0100867)	1.81784775
80	Small intestinal stenosis (HP:0012848)	1.81784775
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.81635199
82	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.81635199
83	Abnormality of dental color (HP:0011073)	1.81291675
84	Increased CSF lactate (HP:0002490)	1.80165279
85	Confusion (HP:0001289)	1.79892649
86	Amelogenesis imperfecta (HP:0000705)	1.78645739
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77350438
88	Optic nerve hypoplasia (HP:0000609)	1.76222028
89	Mitochondrial inheritance (HP:0001427)	1.75309088
90	Preaxial foot polydactyly (HP:0001841)	1.75239234
91	Pendular nystagmus (HP:0012043)	1.74345303
92	Hepatic necrosis (HP:0002605)	1.72051335
93	Type II lissencephaly (HP:0007260)	1.71354355
94	Vaginal atresia (HP:0000148)	1.71094568
95	Abnormality of chromosome stability (HP:0003220)	1.69081703
96	Sclerocornea (HP:0000647)	1.69002323
97	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.68452211
98	Renal Fanconi syndrome (HP:0001994)	1.67504527
99	Infertility (HP:0000789)	1.67461010
100	Chronic bronchitis (HP:0004469)	1.65525564

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.30742574
2	FRK	3.97578548
3	MAP4K2	3.90526532
4	WNK3	3.73121958
5	PBK	3.08749750
6	PINK1	2.68848206
7	PLK2	2.59496225
8	STK38L	2.58070498
9	ZAK	2.41965159
10	INSRR	2.05721358
11	PNCK	2.05140375
12	CASK	1.93230126
13	MAP3K4	1.91414354
14	TRIM28	1.80295280
15	TXK	1.58568214
16	EIF2AK3	1.58336301
17	SRPK1	1.50278334
18	WNK4	1.49801625
19	TIE1	1.48139138
20	TESK1	1.39460381
21	TTK	1.38111460
22	CDK19	1.37676988
23	MAP2K7	1.30004630
24	STK39	1.29088999
25	TAF1	1.28473247
26	VRK2	1.24872069
27	GRK1	1.24828524
28	PLK3	1.24776699
29	VRK1	1.20663160
30	FER	1.19251920
31	DYRK2	1.11223721
32	NEK1	1.10411245
33	BCR	1.09797918
34	BMPR1B	1.08633275
35	BCKDK	1.08300130
36	MAP3K6	1.06475407
37	WEE1	1.05704845
38	MAPK13	1.05300877
39	OXSR1	1.03552466
40	CDC7	1.03278745
41	ADRBK2	0.99691102
42	MKNK1	0.97734698
43	NME1	0.95785588
44	RPS6KA4	0.94335238
45	PAK3	0.90456542
46	NUAK1	0.89234034
47	STK38	0.86950923
48	PLK1	0.84172833
49	TAOK3	0.82427054
50	TSSK6	0.79588750
51	MAPKAPK3	0.77335516
52	DDR2	0.77240045
53	FLT3	0.74580088
54	BRSK2	0.73401400
55	MUSK	0.73236395
56	ACVR1B	0.72432709
57	CDK3	0.71069833
58	STK16	0.70556294
59	MST4	0.70234043
60	CSNK1G2	0.66250710
61	MARK1	0.65024943
62	ERBB3	0.63729089
63	CHEK2	0.59351511
64	MAP2K6	0.56807012
65	WNK1	0.55664706
66	PRKCG	0.55228349
67	DYRK3	0.52428846
68	MINK1	0.51340846
69	ADRBK1	0.49323112
70	CAMK1G	0.48227172
71	MKNK2	0.47875618
72	PASK	0.47718210
73	PIK3CG	0.47696180
74	MAP2K4	0.46313572
75	PRKCE	0.45419164
76	CSNK1G1	0.45237306
77	LIMK1	0.44705772
78	NEK6	0.42553598
79	CDK7	0.42515492
80	PRKCZ	0.41969122
81	CAMK1	0.41263517
82	MAPK15	0.40580128
83	CSNK1G3	0.40457168
84	PRKG1	0.40065452
85	CSNK1A1	0.39290633
86	CAMK2A	0.37601934
87	MAP2K1	0.35532412
88	ATR	0.35200598
89	PRKCB	0.35109454
90	IGF1R	0.32903269
91	KSR1	0.32214609
92	ATM	0.31784305
93	CSNK1E	0.31434014
94	MAPKAPK5	0.31378434
95	DYRK1A	0.30971345
96	CSNK2A1	0.29046447
97	FGFR1	0.28993725
98	PRKACA	0.28948891
99	KIT	0.28758965
100	YES1	0.28600675

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.53131600
2	Proteasome_Homo sapiens_hsa03050	2.83713090
3	Propanoate metabolism_Homo sapiens_hsa00640	2.65738066
4	Butanoate metabolism_Homo sapiens_hsa00650	2.48321400
5	RNA transport_Homo sapiens_hsa03013	2.42213241
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.40577486
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.34181388
8	DNA replication_Homo sapiens_hsa03030	2.11943158
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06496140
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03727399
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.02963942
12	Base excision repair_Homo sapiens_hsa03410	1.93707908
13	Protein export_Homo sapiens_hsa03060	1.81249293
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.81114233
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80691229
16	RNA degradation_Homo sapiens_hsa03018	1.79049972
17	Mismatch repair_Homo sapiens_hsa03430	1.77989365
18	Basal transcription factors_Homo sapiens_hsa03022	1.77662262
19	Homologous recombination_Homo sapiens_hsa03440	1.75146487
20	RNA polymerase_Homo sapiens_hsa03020	1.74484639
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73501438
22	Olfactory transduction_Homo sapiens_hsa04740	1.71047984
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71005564
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.68087150
25	Phototransduction_Homo sapiens_hsa04744	1.61577371
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61025385
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55977011
28	Parkinsons disease_Homo sapiens_hsa05012	1.50582481
29	Peroxisome_Homo sapiens_hsa04146	1.45864919
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.45118410
31	Nicotine addiction_Homo sapiens_hsa05033	1.41225808
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.37408719
33	Huntingtons disease_Homo sapiens_hsa05016	1.32783438
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.28504286
35	Glutathione metabolism_Homo sapiens_hsa00480	1.24606999
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23054335
37	Fatty acid elongation_Homo sapiens_hsa00062	1.20949173
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20613141
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.19538076
40	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.18941902
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16561245
42	Taste transduction_Homo sapiens_hsa04742	1.12591473
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.12283325
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11088041
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10927179
46	One carbon pool by folate_Homo sapiens_hsa00670	1.09273254
47	Spliceosome_Homo sapiens_hsa03040	1.07985600
48	Purine metabolism_Homo sapiens_hsa00230	1.05690454
49	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05189002
50	Tryptophan metabolism_Homo sapiens_hsa00380	1.04014616
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02715521
52	Fatty acid degradation_Homo sapiens_hsa00071	0.99219554
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.91953774
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.91705135
55	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.91436178
56	Metabolic pathways_Homo sapiens_hsa01100	0.91084986
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.89644534
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85007912
59	ABC transporters_Homo sapiens_hsa02010	0.80814078
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.78935993
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76663298
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74973316
63	Salivary secretion_Homo sapiens_hsa04970	0.73758434
64	Alzheimers disease_Homo sapiens_hsa05010	0.73753022
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.73207794
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.71461594
67	Oocyte meiosis_Homo sapiens_hsa04114	0.70803062
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70480875
69	Serotonergic synapse_Homo sapiens_hsa04726	0.70049957
70	Retinol metabolism_Homo sapiens_hsa00830	0.69900034
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68091873
72	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.67364287
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.64483872
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62701710
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60982551
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59155006
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57884642
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.57138558
79	Folate biosynthesis_Homo sapiens_hsa00790	0.56548296
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54952384
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.53792342
82	p53 signaling pathway_Homo sapiens_hsa04115	0.50989193
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47513782
84	Morphine addiction_Homo sapiens_hsa05032	0.47346674
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46673912
86	Regulation of autophagy_Homo sapiens_hsa04140	0.46120696
87	GABAergic synapse_Homo sapiens_hsa04727	0.45648675
88	Ribosome_Homo sapiens_hsa03010	0.45552419
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45530874
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44773886
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44457407
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42852601
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40226111
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39000000
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38144683
96	Cell cycle_Homo sapiens_hsa04110	0.37581323
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.37367817
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34551425
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32859078
100	Carbon metabolism_Homo sapiens_hsa01200	0.31142337

NPIPA2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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