ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.92460801
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.64315966
3	substrate-independent telencephalic tangential migration (GO:0021826)	4.64315966
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.97382868
5	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.97336606
6	nonmotile primary cilium assembly (GO:0035058)	3.87945753
7	regulation of cilium movement (GO:0003352)	3.81349905
8	neurofilament cytoskeleton organization (GO:0060052)	3.48568365
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.45799050
10	protein complex biogenesis (GO:0070271)	3.43865957
11	glycerophospholipid catabolic process (GO:0046475)	3.41589200
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.39615569
13	viral transcription (GO:0019083)	3.34279747
14	protein neddylation (GO:0045116)	3.32440853
15	ribosomal small subunit biogenesis (GO:0042274)	3.30486390
16	maturation of SSU-rRNA (GO:0030490)	3.30481223
17	nucleobase catabolic process (GO:0046113)	3.30112528
18	translational termination (GO:0006415)	3.26934378
19	protein polyglutamylation (GO:0018095)	3.26779150
20	chaperone-mediated protein transport (GO:0072321)	3.25687984
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24313710
22	NADH dehydrogenase complex assembly (GO:0010257)	3.24313710
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24313710
24	ribosomal small subunit assembly (GO:0000028)	3.24306259
25	presynaptic membrane organization (GO:0097090)	3.22590199
26	parturition (GO:0007567)	3.19623428
27	axon ensheathment in central nervous system (GO:0032291)	3.19261140
28	central nervous system myelination (GO:0022010)	3.19261140
29	negative regulation of response to food (GO:0032096)	3.18378666
30	negative regulation of appetite (GO:0032099)	3.18378666
31	cell proliferation in forebrain (GO:0021846)	3.16326466
32	epithelial cilium movement (GO:0003351)	3.14595372
33	regulation of microtubule-based movement (GO:0060632)	3.13807850
34	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.09942941
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06796529
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03985418
37	postsynaptic membrane organization (GO:0001941)	2.99140039
38	axonal fasciculation (GO:0007413)	2.99070229
39	establishment of mitochondrion localization (GO:0051654)	2.97953140
40	ATP synthesis coupled proton transport (GO:0015986)	2.97451843
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97451843
42	dendritic spine morphogenesis (GO:0060997)	2.94430562
43	tongue development (GO:0043586)	2.87314497
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.83296253
45	synaptic transmission, cholinergic (GO:0007271)	2.81966620
46	acrosome reaction (GO:0007340)	2.81536812
47	intraciliary transport (GO:0042073)	2.81147642
48	axoneme assembly (GO:0035082)	2.78957775
49	presynaptic membrane assembly (GO:0097105)	2.75692821
50	mitochondrion transport along microtubule (GO:0047497)	2.75260967
51	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.75260967
52	respiratory chain complex IV assembly (GO:0008535)	2.73838184
53	forebrain neuron differentiation (GO:0021879)	2.71767116
54	cotranslational protein targeting to membrane (GO:0006613)	2.69347064
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.68915980
56	translational elongation (GO:0006414)	2.67787404
57	protein targeting to ER (GO:0045047)	2.67619094
58	short-term memory (GO:0007614)	2.67303486
59	transmission of nerve impulse (GO:0019226)	2.67216573
60	neuron recognition (GO:0008038)	2.64826216
61	negative regulation of telomere maintenance (GO:0032205)	2.63841581
62	electron transport chain (GO:0022900)	2.62161638
63	behavioral response to ethanol (GO:0048149)	2.61858971
64	regulation of appetite (GO:0032098)	2.60820492
65	respiratory electron transport chain (GO:0022904)	2.60739047
66	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.58613359
67	cytochrome complex assembly (GO:0017004)	2.58233578
68	somite development (GO:0061053)	2.56973247
69	tachykinin receptor signaling pathway (GO:0007217)	2.56600691
70	protein localization to endoplasmic reticulum (GO:0070972)	2.56001836
71	single strand break repair (GO:0000012)	2.55765859
72	retinal ganglion cell axon guidance (GO:0031290)	2.55187697
73	body morphogenesis (GO:0010171)	2.54757817
74	regulation of action potential (GO:0098900)	2.53367458
75	sperm motility (GO:0030317)	2.53320229
76	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.52566595
77	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50602695
78	detection of light stimulus involved in visual perception (GO:0050908)	2.49452853
79	detection of light stimulus involved in sensory perception (GO:0050962)	2.49452853
80	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.47560747
81	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.47560747
82	cilium movement (GO:0003341)	2.46895798
83	brain morphogenesis (GO:0048854)	2.46051696
84	replication fork processing (GO:0031297)	2.45652844
85	microtubule bundle formation (GO:0001578)	2.45288171
86	viral life cycle (GO:0019058)	2.45261336
87	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.45105700
88	positive regulation of growth hormone secretion (GO:0060124)	2.44910410
89	response to pheromone (GO:0019236)	2.44347907
90	cerebral cortex radially oriented cell migration (GO:0021799)	2.43530858
91	cellular protein complex disassembly (GO:0043624)	2.41299624
92	seminiferous tubule development (GO:0072520)	2.40933622
93	neuronal action potential propagation (GO:0019227)	2.40898159
94	neuronal ion channel clustering (GO:0045161)	2.39654315
95	head development (GO:0060322)	2.39013919
96	calcium ion-dependent exocytosis (GO:0017156)	2.38449922
97	piRNA metabolic process (GO:0034587)	2.38305032
98	establishment of protein localization to Golgi (GO:0072600)	2.37140033
99	positive regulation of mitochondrial fission (GO:0090141)	2.36654431
100	genetic imprinting (GO:0071514)	2.36121555

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.57412069
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.27212410
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.25431295
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85819817
5	REST_21632747_ChIP-Seq_MESCs_Mouse	2.33912110
6	VDR_22108803_ChIP-Seq_LS180_Human	2.32362570
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13027478
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11916964
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.10630560
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.05475086
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97860669
12	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95544652
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.85623296
14	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.82399833
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79197873
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.75138263
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.74448798
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72049335
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70024394
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67643652
21	FUS_26573619_Chip-Seq_HEK293_Human	1.61183653
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60398233
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60245698
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58751297
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.55787272
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.55494659
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55294151
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.55007513
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.54389141
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.53975186
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53298439
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.50904120
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45882042
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.43427935
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43010504
36	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42934618
37	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.40500174
38	P300_19829295_ChIP-Seq_ESCs_Human	1.38393931
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.36880647
40	EWS_26573619_Chip-Seq_HEK293_Human	1.35976099
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.34803518
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.33847037
43	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31143013
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29100257
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.28954258
46	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28552354
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25303124
48	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.21013110
49	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.20509316
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.20413087
51	NCOR_22424771_ChIP-Seq_293T_Human	1.20190898
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18098213
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.18098213
54	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.17808574
55	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17575225
56	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.15579382
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.15579382
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.15466922
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13672088
60	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.13286265
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12980533
62	ERA_21632823_ChIP-Seq_H3396_Human	1.12384425
63	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.11753917
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.11703344
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11495939
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09474261
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09434860
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09351474
69	AR_25329375_ChIP-Seq_VCAP_Human	1.07682532
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06537902
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06398506
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04769421
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04090751
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03345450
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01218074
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01218074
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01057842
78	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.00705172
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00158591
80	MYC_19829295_ChIP-Seq_ESCs_Human	0.99577656
81	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.98708457
82	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98424541
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.98066539
84	STAT3_23295773_ChIP-Seq_U87_Human	0.97554479
85	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97524613
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95346455
87	TCF4_23295773_ChIP-Seq_U87_Human	0.95321660
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95019356
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94918732
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94835026
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.93731153
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92848700
93	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92363704
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91194623
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90908954
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.89658805
97	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.89235625
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88233414
99	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.87209624
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.86978443

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.27229037
2	MP0006292_abnormal_olfactory_placode	3.13206172
3	MP0008877_abnormal_DNA_methylation	2.89992886
4	MP0009379_abnormal_foot_pigmentation	2.75057466
5	MP0002653_abnormal_ependyma_morphology	2.74386897
6	MP0003123_paternal_imprinting	2.73047169
7	MP0003122_maternal_imprinting	2.46655703
8	MP0006276_abnormal_autonomic_nervous	2.45824637
9	MP0003121_genomic_imprinting	2.38162211
10	MP0008789_abnormal_olfactory_epithelium	2.23931544
11	MP0004142_abnormal_muscle_tone	2.14174330
12	MP0003880_abnormal_central_pattern	2.12392900
13	MP0003136_yellow_coat_color	2.11150517
14	MP0001529_abnormal_vocalization	2.09785635
15	MP0005394_taste/olfaction_phenotype	1.98751271
16	MP0005499_abnormal_olfactory_system	1.98751271
17	MP0001984_abnormal_olfaction	1.94563638
18	MP0001968_abnormal_touch/_nociception	1.92162345
19	MP0000778_abnormal_nervous_system	1.88861177
20	MP0001188_hyperpigmentation	1.77742052
21	MP0002272_abnormal_nervous_system	1.75736167
22	MP0005551_abnormal_eye_electrophysiolog	1.72412583
23	MP0005423_abnormal_somatic_nervous	1.70965637
24	MP0002822_catalepsy	1.69811276
25	MP0009046_muscle_twitch	1.61506502
26	MP0005084_abnormal_gallbladder_morpholo	1.59349400
27	MP0002163_abnormal_gland_morphology	1.58918367
28	MP0004885_abnormal_endolymph	1.58806900
29	MP0009745_abnormal_behavioral_response	1.57846093
30	MP0003646_muscle_fatigue	1.57712021
31	MP0002736_abnormal_nociception_after	1.57641360
32	MP0000955_abnormal_spinal_cord	1.57010421
33	MP0002102_abnormal_ear_morphology	1.56745400
34	MP0001293_anophthalmia	1.55494034
35	MP0001905_abnormal_dopamine_level	1.55492703
36	MP0001485_abnormal_pinna_reflex	1.52958452
37	MP0002184_abnormal_innervation	1.52805762
38	MP0003011_delayed_dark_adaptation	1.52445457
39	MP0002160_abnormal_reproductive_system	1.52237902
40	MP0002837_dystrophic_cardiac_calcinosis	1.50421151
41	MP0002557_abnormal_social/conspecific_i	1.49224655
42	MP0002572_abnormal_emotion/affect_behav	1.47642831
43	MP0004859_abnormal_synaptic_plasticity	1.43365248
44	MP0001486_abnormal_startle_reflex	1.40970665
45	MP0004133_heterotaxia	1.40020065
46	MP0002638_abnormal_pupillary_reflex	1.39605014
47	MP0001970_abnormal_pain_threshold	1.38095226
48	MP0002063_abnormal_learning/memory/cond	1.37222761
49	MP0003635_abnormal_synaptic_transmissio	1.36823940
50	MP0002733_abnormal_thermal_nociception	1.33410925
51	MP0000631_abnormal_neuroendocrine_gland	1.33063343
52	MP0002876_abnormal_thyroid_physiology	1.28649418
53	MP0005377_hearing/vestibular/ear_phenot	1.26660934
54	MP0003878_abnormal_ear_physiology	1.26660934
55	MP0002752_abnormal_somatic_nervous	1.26279709
56	MP0005379_endocrine/exocrine_gland_phen	1.24935195
57	MP0002734_abnormal_mechanical_nocicepti	1.24818426
58	MP0002138_abnormal_hepatobiliary_system	1.22861812
59	MP0002735_abnormal_chemical_nociception	1.21034029
60	MP0006072_abnormal_retinal_apoptosis	1.19563270
61	MP0005389_reproductive_system_phenotype	1.18088108
62	MP0005195_abnormal_posterior_eye	1.15824626
63	MP0002067_abnormal_sensory_capabilities	1.13969355
64	MP0002064_seizures	1.13800906
65	MP0002882_abnormal_neuron_morphology	1.13224311
66	MP0004145_abnormal_muscle_electrophysio	1.11517448
67	MP0001440_abnormal_grooming_behavior	1.08047334
68	MP0002928_abnormal_bile_duct	1.06470099
69	MP0005646_abnormal_pituitary_gland	1.05428925
70	MP0002938_white_spotting	1.05352068
71	MP0000049_abnormal_middle_ear	1.02218143
72	MP0003890_abnormal_embryonic-extraembry	1.01999517
73	MP0005410_abnormal_fertilization	1.00628209
74	MP0004811_abnormal_neuron_physiology	1.00237059
75	MP0005645_abnormal_hypothalamus_physiol	0.99378183
76	MP0002909_abnormal_adrenal_gland	0.99032344
77	MP0004924_abnormal_behavior	0.97828631
78	MP0005386_behavior/neurological_phenoty	0.97828631
79	MP0002210_abnormal_sex_determination	0.96584202
80	MP0004742_abnormal_vestibular_system	0.95662599
81	MP0002229_neurodegeneration	0.92655155
82	MP0001919_abnormal_reproductive_system	0.91985105
83	MP0000026_abnormal_inner_ear	0.91756053
84	MP0002152_abnormal_brain_morphology	0.90338754
85	MP0003698_abnormal_male_reproductive	0.89125055
86	MP0008875_abnormal_xenobiotic_pharmacok	0.88892579
87	MP0004147_increased_porphyrin_level	0.87816208
88	MP0005253_abnormal_eye_physiology	0.84018979
89	MP0008872_abnormal_physiological_respon	0.82444686
90	MP0000230_abnormal_systemic_arterial	0.82268110
91	MP0001963_abnormal_hearing_physiology	0.81938979
92	MP0005174_abnormal_tail_pigmentation	0.81050544
93	MP0003861_abnormal_nervous_system	0.80555249
94	MP0001986_abnormal_taste_sensitivity	0.77493171
95	MP0002234_abnormal_pharynx_morphology	0.74727036
96	MP0008058_abnormal_DNA_repair	0.74549814
97	MP0001324_abnormal_eye_pigmentation	0.74499680
98	MP0001929_abnormal_gametogenesis	0.74493369
99	MP0002095_abnormal_skin_pigmentation	0.74422219
100	MP0004043_abnormal_pH_regulation	0.74074363

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	3.86526675
2	Abnormality of midbrain morphology (HP:0002418)	3.86526675
3	Medial flaring of the eyebrow (HP:0010747)	3.60736841
4	Pancreatic fibrosis (HP:0100732)	3.51148699
5	Nephronophthisis (HP:0000090)	3.46079740
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.27740342
7	Acute necrotizing encephalopathy (HP:0006965)	3.20102838
8	Gait imbalance (HP:0002141)	3.18910515
9	Pancreatic cysts (HP:0001737)	3.14843395
10	Reticulocytopenia (HP:0001896)	3.13168805
11	Abnormality of the labia minora (HP:0012880)	3.01661261
12	Congenital stationary night blindness (HP:0007642)	3.00879476
13	Rib fusion (HP:0000902)	2.99783569
14	True hermaphroditism (HP:0010459)	2.99585906
15	Congenital primary aphakia (HP:0007707)	2.93003221
16	Abnormality of cells of the erythroid lineage (HP:0012130)	2.92126434
17	Nephrogenic diabetes insipidus (HP:0009806)	2.88417388
18	Abnormality of the renal medulla (HP:0100957)	2.84399057
19	Acute encephalopathy (HP:0006846)	2.81674175
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.73377965
21	Polyphagia (HP:0002591)	2.69709211
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.66516004
23	Progressive macrocephaly (HP:0004481)	2.62135179
24	Mitochondrial inheritance (HP:0001427)	2.56932978
25	Chronic hepatic failure (HP:0100626)	2.52590804
26	Poor suck (HP:0002033)	2.52005278
27	Colon cancer (HP:0003003)	2.49168348
28	Myokymia (HP:0002411)	2.47389597
29	Septo-optic dysplasia (HP:0100842)	2.42803794
30	Genital tract atresia (HP:0001827)	2.42695330
31	Poor coordination (HP:0002370)	2.42668025
32	Type II lissencephaly (HP:0007260)	2.41874922
33	Tubular atrophy (HP:0000092)	2.40324817
34	Vaginal atresia (HP:0000148)	2.38986532
35	Increased CSF lactate (HP:0002490)	2.36355517
36	Abnormal drinking behavior (HP:0030082)	2.36347340
37	Polydipsia (HP:0001959)	2.36347340
38	Hyperthyroidism (HP:0000836)	2.33459930
39	Abnormal pancreas size (HP:0012094)	2.32007785
40	Adrenal hypoplasia (HP:0000835)	2.31344885
41	Sclerocornea (HP:0000647)	2.31320046
42	Neoplasm of the adrenal cortex (HP:0100641)	2.31295885
43	Abolished electroretinogram (ERG) (HP:0000550)	2.31153592
44	Hyperglycinemia (HP:0002154)	2.29418482
45	Abnormal number of erythroid precursors (HP:0012131)	2.26872146
46	Bony spicule pigmentary retinopathy (HP:0007737)	2.21076797
47	Anencephaly (HP:0002323)	2.18485023
48	Lipid accumulation in hepatocytes (HP:0006561)	2.17726692
49	Agitation (HP:0000713)	2.17209171
50	Optic nerve hypoplasia (HP:0000609)	2.16733893
51	Hepatocellular necrosis (HP:0001404)	2.13859210
52	Cystic liver disease (HP:0006706)	2.13680814
53	Growth hormone deficiency (HP:0000824)	2.13325178
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10535267
55	Absent/shortened dynein arms (HP:0200106)	2.10535267
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06426994
57	Increased hepatocellular lipid droplets (HP:0006565)	2.06160263
58	Renal Fanconi syndrome (HP:0001994)	2.05418783
59	Limb dystonia (HP:0002451)	2.04972296
60	Pachygyria (HP:0001302)	2.04946145
61	Absent thumb (HP:0009777)	2.01441357
62	Spastic tetraplegia (HP:0002510)	2.01136702
63	Macrocytic anemia (HP:0001972)	2.00383915
64	Hyperventilation (HP:0002883)	1.99979119
65	Abnormality of the aortic arch (HP:0012303)	1.99237653
66	Hypogonadotrophic hypogonadism (HP:0000044)	1.98406624
67	Hepatic necrosis (HP:0002605)	1.97989281
68	Lissencephaly (HP:0001339)	1.97675170
69	Specific learning disability (HP:0001328)	1.96651492
70	Abnormality of the renal cortex (HP:0011035)	1.95700953
71	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95423970
72	Severe visual impairment (HP:0001141)	1.93076471
73	Pendular nystagmus (HP:0012043)	1.91949896
74	Hepatoblastoma (HP:0002884)	1.91176503
75	Narrow forehead (HP:0000341)	1.90711652
76	Type 2 muscle fiber atrophy (HP:0003554)	1.90283637
77	Cerebral edema (HP:0002181)	1.87365401
78	Hip dysplasia (HP:0001385)	1.87310908
79	Postaxial hand polydactyly (HP:0001162)	1.87183833
80	Abnormality of urine glucose concentration (HP:0011016)	1.86905793
81	Glycosuria (HP:0003076)	1.86905793
82	Abnormal hair whorl (HP:0010721)	1.85841071
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84644537
84	Polyuria (HP:0000103)	1.84476597
85	Oligodactyly (hands) (HP:0001180)	1.83418595
86	Anomalous pulmonary venous return (HP:0010772)	1.82898687
87	Male pseudohermaphroditism (HP:0000037)	1.82569008
88	Postaxial foot polydactyly (HP:0001830)	1.82377176
89	Asplenia (HP:0001746)	1.82090191
90	Failure to thrive in infancy (HP:0001531)	1.81002574
91	Optic disc pallor (HP:0000543)	1.80297978
92	Enlarged penis (HP:0000040)	1.79418776
93	Hypoplasia of the fovea (HP:0007750)	1.78668975
94	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78668975
95	Abnormality of renal resorption (HP:0011038)	1.78294523
96	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77841608
97	Retinal dysplasia (HP:0007973)	1.76124479
98	Anophthalmia (HP:0000528)	1.73877977
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73680176
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.73680176

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.06718369
2	STK16	3.63062188
3	CASK	3.29799570
4	PINK1	3.28790266
5	WNK4	3.27211158
6	WNK3	2.36764249
7	DYRK2	2.36679126
8	NTRK3	2.22514898
9	MAP4K2	2.01515209
10	BMPR1B	1.95370805
11	MARK1	1.94115864
12	GRK1	1.78683143
13	MAP3K4	1.78488531
14	ADRBK2	1.78373520
15	MAP2K7	1.76275821
16	MINK1	1.71655694
17	PAK3	1.70130569
18	STK39	1.65495334
19	PNCK	1.61991100
20	ZAK	1.60912313
21	NTRK2	1.56741784
22	PRKCG	1.53052662
23	MAPK13	1.51273757
24	NUAK1	1.51176017
25	CDK19	1.46654679
26	TNIK	1.41550696
27	PIK3CA	1.39262216
28	CAMK1G	1.26631365
29	TRIM28	1.18029127
30	TIE1	1.17289348
31	CDC7	1.15271029
32	OXSR1	1.14218887
33	CAMK1	1.12533387
34	MAP3K9	1.07793825
35	PLK4	1.06916480
36	CAMK1D	1.03902195
37	STK11	1.02990829
38	CSNK1G2	1.01562860
39	SGK494	0.99738208
40	SGK223	0.99738208
41	PLK2	0.97994442
42	TLK1	0.97772207
43	EPHA4	0.96714600
44	PRKCH	0.96192697
45	BRAF	0.93368263
46	TYRO3	0.91621394
47	MARK2	0.90300269
48	BCKDK	0.88434927
49	INSRR	0.88143213
50	EPHB2	0.82405397
51	NME1	0.81100413
52	CSNK1E	0.77170058
53	PRKCZ	0.76010437
54	PRKCQ	0.74860802
55	PHKG2	0.73394934
56	PHKG1	0.73394934
57	PLK1	0.73096009
58	LIMK1	0.71087602
59	DYRK3	0.70661946
60	MUSK	0.68963189
61	CAMKK2	0.66922571
62	DAPK2	0.66156074
63	DMPK	0.66119514
64	WNK1	0.65128985
65	STK3	0.65018796
66	CSNK1G3	0.64386097
67	CSNK1A1	0.63931687
68	PRKACA	0.63182235
69	SGK1	0.62579159
70	PRKCI	0.61966202
71	MKNK2	0.61884861
72	PLK3	0.60458857
73	VRK1	0.59696902
74	PRKD3	0.59692049
75	SGK2	0.59638699
76	RPS6KA2	0.59322257
77	ADRBK1	0.59299053
78	FGFR2	0.57751738
79	CSNK1G1	0.56942107
80	PRKCE	0.56150203
81	CDK5	0.55035245
82	CAMK2A	0.54865777
83	AURKA	0.53698546
84	STK38L	0.50928309
85	VRK2	0.48463282
86	DYRK1A	0.47101232
87	MAP2K4	0.44234856
88	CSNK2A2	0.41338642
89	RPS6KA6	0.40816334
90	ABL2	0.40239298
91	CAMKK1	0.39809349
92	BCR	0.39306507
93	CSNK1A1L	0.38939922
94	DYRK1B	0.38570586
95	AKT1	0.38435357
96	MAP3K11	0.38383476
97	PRKDC	0.37547566
98	PAK6	0.37312515
99	TAOK3	0.36601603
100	PRKCA	0.36351520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62752173
2	Ribosome_Homo sapiens_hsa03010	3.59186191
3	Parkinsons disease_Homo sapiens_hsa05012	3.02966508
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60523434
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54964619
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.35638347
7	Huntingtons disease_Homo sapiens_hsa05016	2.19819638
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17011240
9	Phototransduction_Homo sapiens_hsa04744	2.16575366
10	Alzheimers disease_Homo sapiens_hsa05010	2.08003336
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.00705449
12	Nicotine addiction_Homo sapiens_hsa05033	1.96714027
13	Protein export_Homo sapiens_hsa03060	1.91572491
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.89445805
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88850279
16	Butanoate metabolism_Homo sapiens_hsa00650	1.87150203
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81306701
18	RNA polymerase_Homo sapiens_hsa03020	1.72066533
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60696180
20	Propanoate metabolism_Homo sapiens_hsa00640	1.55807158
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46355216
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45378175
23	Homologous recombination_Homo sapiens_hsa03440	1.43720903
24	Insulin secretion_Homo sapiens_hsa04911	1.41102293
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39659980
26	Morphine addiction_Homo sapiens_hsa05032	1.38712630
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.35476562
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.34786473
29	Peroxisome_Homo sapiens_hsa04146	1.33163602
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31205755
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.30384654
32	GABAergic synapse_Homo sapiens_hsa04727	1.24595023
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.20067223
34	Basal transcription factors_Homo sapiens_hsa03022	1.19919820
35	RNA degradation_Homo sapiens_hsa03018	1.16580187
36	Olfactory transduction_Homo sapiens_hsa04740	1.15620107
37	Serotonergic synapse_Homo sapiens_hsa04726	1.13178021
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10153133
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09283648
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08503231
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07234856
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.06412252
43	Dopaminergic synapse_Homo sapiens_hsa04728	1.03068909
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.00260717
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.97025283
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94365102
47	Sulfur relay system_Homo sapiens_hsa04122	0.92900902
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90700195
49	Axon guidance_Homo sapiens_hsa04360	0.89159141
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.87911018
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.86651746
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.85694821
53	Folate biosynthesis_Homo sapiens_hsa00790	0.82816895
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.82779426
55	Circadian entrainment_Homo sapiens_hsa04713	0.80354656
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78594025
57	Metabolic pathways_Homo sapiens_hsa01100	0.77888663
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77241155
59	Fatty acid degradation_Homo sapiens_hsa00071	0.77001490
60	Long-term depression_Homo sapiens_hsa04730	0.76128914
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75802727
62	Regulation of autophagy_Homo sapiens_hsa04140	0.75689842
63	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.75318180
64	Taste transduction_Homo sapiens_hsa04742	0.73245990
65	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.72408866
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71719790
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.68667457
68	Cholinergic synapse_Homo sapiens_hsa04725	0.67823026
69	Purine metabolism_Homo sapiens_hsa00230	0.66423829
70	Proteasome_Homo sapiens_hsa03050	0.65922876
71	Fatty acid elongation_Homo sapiens_hsa00062	0.64708695
72	Retinol metabolism_Homo sapiens_hsa00830	0.63820660
73	Mismatch repair_Homo sapiens_hsa03430	0.61424512
74	Cocaine addiction_Homo sapiens_hsa05030	0.60493228
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.60246875
76	Base excision repair_Homo sapiens_hsa03410	0.57427496
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54754266
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54289297
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53680868
80	RNA transport_Homo sapiens_hsa03013	0.52590623
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51991542
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.51508337
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.51455167
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.50849621
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48768048
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45549450
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.45225312
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44888901
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44743025
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44664462
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44263151
92	One carbon pool by folate_Homo sapiens_hsa00670	0.44229583
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43408669
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40656531
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.39898047
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.39053479
97	Caffeine metabolism_Homo sapiens_hsa00232	0.37625612
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35802059
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35251027
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33764193

NPIPA3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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