ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.17869952
2	rRNA methylation (GO:0031167)	4.86568090
3	sperm motility (GO:0030317)	4.76770290
4	piRNA metabolic process (GO:0034587)	4.51197411
5	rRNA modification (GO:0000154)	4.38478798
6	acrosome reaction (GO:0007340)	4.24977001
7	axonemal dynein complex assembly (GO:0070286)	3.81593175
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.78536419
9	axoneme assembly (GO:0035082)	3.76842437
10	male meiosis I (GO:0007141)	3.69676324
11	regulation of meiosis I (GO:0060631)	3.67482531
12	microtubule depolymerization (GO:0007019)	3.62809981
13	synapsis (GO:0007129)	3.58667783
14	fusion of sperm to egg plasma membrane (GO:0007342)	3.56337224
15	protein polyglutamylation (GO:0018095)	3.52167251
16	spermatid development (GO:0007286)	3.51211922
17	seminiferous tubule development (GO:0072520)	3.48411464
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.39847818
19	fucose catabolic process (GO:0019317)	3.38407223
20	L-fucose metabolic process (GO:0042354)	3.38407223
21	L-fucose catabolic process (GO:0042355)	3.38407223
22	resolution of meiotic recombination intermediates (GO:0000712)	3.37585251
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.36926012
24	establishment of protein localization to Golgi (GO:0072600)	3.36885850
25	epithelial cilium movement (GO:0003351)	3.36212928
26	regulation of glucokinase activity (GO:0033131)	3.34221514
27	regulation of hexokinase activity (GO:1903299)	3.34221514
28	protein targeting to Golgi (GO:0000042)	3.33609293
29	presynaptic membrane assembly (GO:0097105)	3.31007679
30	regulation of cilium movement (GO:0003352)	3.29363331
31	cellular ketone body metabolic process (GO:0046950)	3.27136327
32	DNA methylation involved in gamete generation (GO:0043046)	3.26218950
33	male meiosis (GO:0007140)	3.20284755
34	phosphatidylethanolamine metabolic process (GO:0046337)	3.18476992
35	single strand break repair (GO:0000012)	3.11558016
36	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.05490951
37	cilium movement (GO:0003341)	3.05020456
38	neuronal action potential (GO:0019228)	3.01046935
39	platelet dense granule organization (GO:0060155)	3.00884812
40	sperm-egg recognition (GO:0035036)	3.00147306
41	positive regulation of meiosis (GO:0045836)	2.99849026
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98199943
43	behavioral response to nicotine (GO:0035095)	2.95174439
44	reciprocal DNA recombination (GO:0035825)	2.94149530
45	reciprocal meiotic recombination (GO:0007131)	2.94149530
46	neuron cell-cell adhesion (GO:0007158)	2.93822716
47	multicellular organism reproduction (GO:0032504)	2.93485126
48	spermatid nucleus differentiation (GO:0007289)	2.92334621
49	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.91358146
50	acrosome assembly (GO:0001675)	2.89972428
51	DNA double-strand break processing (GO:0000729)	2.89385368
52	positive regulation of meiotic cell cycle (GO:0051446)	2.89238722
53	postsynaptic membrane organization (GO:0001941)	2.88716041
54	protein localization to Golgi apparatus (GO:0034067)	2.83925878
55	presynaptic membrane organization (GO:0097090)	2.83661815
56	centriole replication (GO:0007099)	2.79973470
57	plasma membrane fusion (GO:0045026)	2.79656438
58	nonmotile primary cilium assembly (GO:0035058)	2.76461982
59	neurotransmitter-gated ion channel clustering (GO:0072578)	2.75912561
60	ketone body metabolic process (GO:1902224)	2.75561461
61	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.73842408
62	mannosylation (GO:0097502)	2.73796417
63	protein K11-linked deubiquitination (GO:0035871)	2.72514565
64	meiosis I (GO:0007127)	2.71502361
65	regulation of timing of cell differentiation (GO:0048505)	2.71244878
66	regulation of respiratory system process (GO:0044065)	2.69573135
67	membrane depolarization during action potential (GO:0086010)	2.67647321
68	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.67126255
69	isotype switching (GO:0045190)	2.67126255
70	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.67126255
71	motile cilium assembly (GO:0044458)	2.65741203
72	cytochrome complex assembly (GO:0017004)	2.65344662
73	glycine transport (GO:0015816)	2.61424801
74	photoreceptor cell maintenance (GO:0045494)	2.59484707
75	reflex (GO:0060004)	2.58064293
76	cilium organization (GO:0044782)	2.57102689
77	hindbrain development (GO:0030902)	2.56677305
78	transmission of nerve impulse (GO:0019226)	2.56543476
79	microtubule polymerization or depolymerization (GO:0031109)	2.55961419
80	cilium assembly (GO:0042384)	2.53050691
81	DNA deamination (GO:0045006)	2.52661664
82	respiratory chain complex IV assembly (GO:0008535)	2.52146699
83	organic cation transport (GO:0015695)	2.51793169
84	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.51467190
85	cell-cell recognition (GO:0009988)	2.51348494
86	male gamete generation (GO:0048232)	2.50964639
87	spermatogenesis (GO:0007283)	2.50618361
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.50454159
89	GTP biosynthetic process (GO:0006183)	2.49830324
90	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.49775071
91	brain morphogenesis (GO:0048854)	2.49149212
92	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45266248
93	auditory receptor cell stereocilium organization (GO:0060088)	2.41685821
94	trivalent inorganic anion homeostasis (GO:0072506)	2.41499562
95	phosphate ion homeostasis (GO:0055062)	2.41499562
96	inner ear receptor stereocilium organization (GO:0060122)	2.39599623
97	nephron epithelium morphogenesis (GO:0072088)	2.39532349
98	nephron tubule morphogenesis (GO:0072078)	2.39532349
99	regulation of male gonad development (GO:2000018)	2.39091596
100	proline transport (GO:0015824)	2.37406206

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08612315
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.01179073
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.84794864
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.82053871
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.68021954
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66353619
7	FUS_26573619_Chip-Seq_HEK293_Human	2.63936040
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47909486
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47536575
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41132222
11	VDR_22108803_ChIP-Seq_LS180_Human	2.33422894
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16076416
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.15709329
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.13447048
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12338325
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.11983795
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11131327
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.96219243
19	EWS_26573619_Chip-Seq_HEK293_Human	1.89998432
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.86194467
21	P300_19829295_ChIP-Seq_ESCs_Human	1.80862289
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.74039059
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74039059
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72266066
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.71954244
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64820329
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64371055
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63027249
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62819033
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62819033
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.61461880
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57288965
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57091412
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.56989320
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56892398
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55817873
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.50582610
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48673171
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48552359
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.47891320
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47658112
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46209049
43	STAT3_23295773_ChIP-Seq_U87_Human	1.45037941
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.44899662
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43482333
46	TCF4_23295773_ChIP-Seq_U87_Human	1.43298243
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42913399
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42323773
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41601952
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.39898522
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39655214
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37335914
53	AR_25329375_ChIP-Seq_VCAP_Human	1.37158846
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34688425
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34564984
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31302129
57	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30653293
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30613471
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30088308
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29934192
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.29303201
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26873582
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25364667
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25364667
65	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.24371536
66	P300_18555785_Chip-Seq_ESCs_Mouse	1.24073874
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23177244
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22276236
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18465981
70	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18207215
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17459846
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16928216
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16928216
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.16448058
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16343637
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14999131
77	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.14677755
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14503573
79	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.12860141
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12805021
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12493046
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12408752
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.12376616
84	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11771903
85	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.09925425
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.08698134
87	NCOR_22424771_ChIP-Seq_293T_Human	1.08584849
88	ETV1_20927104_ChIP-Seq_GIST48_Human	1.05294078
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04499894
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03936054
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03766503
92	MYC_19829295_ChIP-Seq_ESCs_Human	1.02767305
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01598824
94	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.00881927
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00654989
96	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99924391
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99895377
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99412043
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99409175
100	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98751204

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.14376177
2	MP0005410_abnormal_fertilization	3.43796415
3	MP0002102_abnormal_ear_morphology	3.20705009
4	MP0001968_abnormal_touch/_nociception	3.19029024
5	MP0006292_abnormal_olfactory_placode	2.76810165
6	MP0002736_abnormal_nociception_after	2.42826920
7	MP0008877_abnormal_DNA_methylation	2.28442919
8	MP0001529_abnormal_vocalization	2.13700273
9	MP0002234_abnormal_pharynx_morphology	2.10271266
10	MP0005075_abnormal_melanosome_morpholog	1.99614693
11	MP0003646_muscle_fatigue	1.98205906
12	MP0008872_abnormal_physiological_respon	1.97871754
13	MP0005423_abnormal_somatic_nervous	1.91261899
14	MP0003880_abnormal_central_pattern	1.90896776
15	MP0005646_abnormal_pituitary_gland	1.90672873
16	MP0001984_abnormal_olfaction	1.88481183
17	MP0003698_abnormal_male_reproductive	1.87616656
18	MP0004885_abnormal_endolymph	1.85941049
19	MP0005551_abnormal_eye_electrophysiolog	1.83781115
20	MP0004270_analgesia	1.81048747
21	MP0008875_abnormal_xenobiotic_pharmacok	1.74074117
22	MP0003195_calcinosis	1.72413406
23	MP0001929_abnormal_gametogenesis	1.68957526
24	MP0001486_abnormal_startle_reflex	1.67446807
25	MP0000566_synostosis	1.65802331
26	MP0002272_abnormal_nervous_system	1.61087307
27	MP0006072_abnormal_retinal_apoptosis	1.56791891
28	MP0002837_dystrophic_cardiac_calcinosis	1.56402275
29	MP0004742_abnormal_vestibular_system	1.52406812
30	MP0009745_abnormal_behavioral_response	1.51555604
31	MP0009046_muscle_twitch	1.48879293
32	MP0002733_abnormal_thermal_nociception	1.45482577
33	MP0009780_abnormal_chondrocyte_physiolo	1.45197438
34	MP0001501_abnormal_sleep_pattern	1.43477348
35	MP0005379_endocrine/exocrine_gland_phen	1.41514538
36	MP0008058_abnormal_DNA_repair	1.39355774
37	MP0005377_hearing/vestibular/ear_phenot	1.38182381
38	MP0003878_abnormal_ear_physiology	1.38182381
39	MP0002734_abnormal_mechanical_nocicepti	1.37413597
40	MP0000631_abnormal_neuroendocrine_gland	1.36695250
41	MP0002138_abnormal_hepatobiliary_system	1.35015600
42	MP0000372_irregular_coat_pigmentation	1.30922867
43	MP0002735_abnormal_chemical_nociception	1.27920649
44	MP0005386_behavior/neurological_phenoty	1.26197133
45	MP0004924_abnormal_behavior	1.26197133
46	MP0004043_abnormal_pH_regulation	1.25300554
47	MP0003635_abnormal_synaptic_transmissio	1.22708195
48	MP0002210_abnormal_sex_determination	1.22653824
49	MP0002572_abnormal_emotion/affect_behav	1.20453577
50	MP0001905_abnormal_dopamine_level	1.18781976
51	MP0008995_early_reproductive_senescence	1.18191626
52	MP0005253_abnormal_eye_physiology	1.17429835
53	MP0000013_abnormal_adipose_tissue	1.15070000
54	MP0001970_abnormal_pain_threshold	1.12958375
55	MP0002184_abnormal_innervation	1.11495472
56	MP0000653_abnormal_sex_gland	1.11462255
57	MP0003567_abnormal_fetal_cardiomyocyte	1.10431753
58	MP0001145_abnormal_male_reproductive	1.09473581
59	MP0002067_abnormal_sensory_capabilities	1.08537291
60	MP0006035_abnormal_mitochondrial_morpho	1.08193360
61	MP0008789_abnormal_olfactory_epithelium	1.06133749
62	MP0002064_seizures	1.04265443
63	MP0005220_abnormal_exocrine_pancreas	1.03091192
64	MP0004147_increased_porphyrin_level	1.02978068
65	MP0002095_abnormal_skin_pigmentation	1.02700901
66	MP0002132_abnormal_respiratory_system	1.02599475
67	MP0004142_abnormal_muscle_tone	0.99644164
68	MP0002938_white_spotting	0.98396103
69	MP0002160_abnormal_reproductive_system	0.98040559
70	MP0001188_hyperpigmentation	0.98025497
71	MP0001986_abnormal_taste_sensitivity	0.97306244
72	MP0000015_abnormal_ear_pigmentation	0.96630527
73	MP0003718_maternal_effect	0.96401768
74	MP0005636_abnormal_mineral_homeostasis	0.94453730
75	MP0005174_abnormal_tail_pigmentation	0.94366055
76	MP0005084_abnormal_gallbladder_morpholo	0.92209214
77	MP0000516_abnormal_urinary_system	0.91977708
78	MP0005367_renal/urinary_system_phenotyp	0.91977708
79	MP0002876_abnormal_thyroid_physiology	0.91802185
80	MP0002557_abnormal_social/conspecific_i	0.91059896
81	MP0004133_heterotaxia	0.90658735
82	MP0001944_abnormal_pancreas_morphology	0.90628588
83	MP0006276_abnormal_autonomic_nervous	0.90140925
84	MP0002161_abnormal_fertility/fecundity	0.89797158
85	MP0005645_abnormal_hypothalamus_physiol	0.89251145
86	MP0002063_abnormal_learning/memory/cond	0.87685240
87	MP0002229_neurodegeneration	0.86974878
88	MP0001963_abnormal_hearing_physiology	0.85397134
89	MP0000026_abnormal_inner_ear	0.79843266
90	MP0002751_abnormal_autonomic_nervous	0.79688109
91	MP0000427_abnormal_hair_cycle	0.79430598
92	MP0005389_reproductive_system_phenotype	0.76452411
93	MP0003786_premature_aging	0.76027865
94	MP0002233_abnormal_nose_morphology	0.75021206
95	MP0002928_abnormal_bile_duct	0.73461440
96	MP0005670_abnormal_white_adipose	0.71429712
97	MP0004145_abnormal_muscle_electrophysio	0.70434717
98	MP0001764_abnormal_homeostasis	0.68830875
99	MP0001765_abnormal_ion_homeostasis	0.67932158
100	MP0003252_abnormal_bile_duct	0.67895353

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.42237331
2	Absent/shortened dynein arms (HP:0200106)	5.42237331
3	Focal motor seizures (HP:0011153)	4.28015603
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.90974854
5	Abnormal respiratory motile cilium morphology (HP:0005938)	3.79490255
6	Abnormal respiratory epithelium morphology (HP:0012253)	3.79490255
7	Abnormal ciliary motility (HP:0012262)	3.70405688
8	Pancreatic fibrosis (HP:0100732)	3.59172700
9	True hermaphroditism (HP:0010459)	3.55006250
10	Decreased central vision (HP:0007663)	3.40751270
11	Nephronophthisis (HP:0000090)	3.39913344
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.34113439
13	Hyperventilation (HP:0002883)	3.16900371
14	Attenuation of retinal blood vessels (HP:0007843)	3.15975487
15	Pancreatic cysts (HP:0001737)	3.14251748
16	Abnormality of the renal medulla (HP:0100957)	3.10030655
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.94551034
18	Abnormality of midbrain morphology (HP:0002418)	2.89791812
19	Molar tooth sign on MRI (HP:0002419)	2.89791812
20	Congenital stationary night blindness (HP:0007642)	2.88532637
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.88294977
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.69093082
23	Stomatitis (HP:0010280)	2.66651445
24	Keratoconus (HP:0000563)	2.63294684
25	Increased corneal curvature (HP:0100692)	2.63294684
26	Medial flaring of the eyebrow (HP:0010747)	2.61289395
27	Cone-rod dystrophy (HP:0000548)	2.60942410
28	Hypoplasia of the thymus (HP:0000778)	2.60419250
29	Type II lissencephaly (HP:0007260)	2.58171831
30	Tubulointerstitial nephritis (HP:0001970)	2.46468439
31	Thyroiditis (HP:0100646)	2.45367847
32	Abolished electroretinogram (ERG) (HP:0000550)	2.44799355
33	Pendular nystagmus (HP:0012043)	2.42409128
34	Polydipsia (HP:0001959)	2.41668499
35	Abnormal drinking behavior (HP:0030082)	2.41668499
36	Nephrogenic diabetes insipidus (HP:0009806)	2.38514311
37	Azoospermia (HP:0000027)	2.32223823
38	Chronic hepatic failure (HP:0100626)	2.29212458
39	Hemiparesis (HP:0001269)	2.28845247
40	Febrile seizures (HP:0002373)	2.27241201
41	Gait imbalance (HP:0002141)	2.26727242
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25959225
43	Abnormality of the renal cortex (HP:0011035)	2.25888694
44	Widely spaced teeth (HP:0000687)	2.22442655
45	Male pseudohermaphroditism (HP:0000037)	2.22159699
46	Focal seizures (HP:0007359)	2.19546743
47	Severe combined immunodeficiency (HP:0004430)	2.16634563
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15388134
49	Congenital primary aphakia (HP:0007707)	2.13757953
50	Cystic liver disease (HP:0006706)	2.09696153
51	Gaze-evoked nystagmus (HP:0000640)	2.09660677
52	Volvulus (HP:0002580)	2.08843683
53	Hypothermia (HP:0002045)	2.07192302
54	Methylmalonic acidemia (HP:0002912)	2.00933835
55	Postaxial foot polydactyly (HP:0001830)	1.99764216
56	Genital tract atresia (HP:0001827)	1.98080600
57	Dialeptic seizures (HP:0011146)	1.96335300
58	Broad-based gait (HP:0002136)	1.96105089
59	Polyuria (HP:0000103)	1.94561089
60	Arthropathy (HP:0003040)	1.93576647
61	Tubulointerstitial abnormality (HP:0001969)	1.93147241
62	Lissencephaly (HP:0001339)	1.92972047
63	Intestinal atresia (HP:0011100)	1.91873636
64	Abnormal spermatogenesis (HP:0008669)	1.89670820
65	Rhinitis (HP:0012384)	1.88408799
66	Sclerocornea (HP:0000647)	1.84726396
67	Congenital hepatic fibrosis (HP:0002612)	1.84363161
68	Amelogenesis imperfecta (HP:0000705)	1.84027142
69	Drooling (HP:0002307)	1.84008090
70	Hypoproteinemia (HP:0003075)	1.83080875
71	Abnormal urine output (HP:0012590)	1.82619689
72	Poor eye contact (HP:0000817)	1.82063526
73	Chronic bronchitis (HP:0004469)	1.82056175
74	Bronchiectasis (HP:0002110)	1.81652767
75	Absence seizures (HP:0002121)	1.75430893
76	Abnormality of macular pigmentation (HP:0008002)	1.74720883
77	Colon cancer (HP:0003003)	1.74669176
78	Abnormality of the labia minora (HP:0012880)	1.73357261
79	Abnormality of B cell number (HP:0010975)	1.72589064
80	Type 2 muscle fiber atrophy (HP:0003554)	1.70858327
81	Panhypogammaglobulinemia (HP:0003139)	1.70776856
82	Median cleft lip (HP:0000161)	1.70652379
83	Specific learning disability (HP:0001328)	1.69717516
84	Retinitis pigmentosa (HP:0000510)	1.69646284
85	Ketoacidosis (HP:0001993)	1.68954180
86	Hypokalemic alkalosis (HP:0001949)	1.68836907
87	Chorioretinal atrophy (HP:0000533)	1.67878010
88	Cerebellar dysplasia (HP:0007033)	1.67447878
89	Infertility (HP:0000789)	1.67283973
90	Severe visual impairment (HP:0001141)	1.67177365
91	B lymphocytopenia (HP:0010976)	1.66981417
92	Vaginal atresia (HP:0000148)	1.66360353
93	Abnormality of endocrine pancreas physiology (HP:0012093)	1.65206876
94	Abnormality of the pancreatic islet cells (HP:0006476)	1.65206876
95	Postaxial hand polydactyly (HP:0001162)	1.64161264
96	Excessive salivation (HP:0003781)	1.62539314
97	Tubular atrophy (HP:0000092)	1.62507566
98	Abnormality of renal excretion (HP:0011036)	1.60882332
99	Fair hair (HP:0002286)	1.60845305
100	Polyphagia (HP:0002591)	1.60703139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.90836837
2	PNCK	3.58336054
3	TNIK	3.47598974
4	FRK	3.46600000
5	WNK4	3.33981446
6	TAF1	2.59581634
7	NUAK1	2.42619096
8	STK39	2.30555151
9	NTRK3	2.27487265
10	OXSR1	2.06396270
11	MAPK13	1.90529069
12	TAOK1	1.80683671
13	CASK	1.79112293
14	PLK4	1.79064621
15	BMPR1B	1.77221031
16	PINK1	1.67733553
17	PLK2	1.65330455
18	ZAK	1.62841975
19	TAOK3	1.61780606
20	ADRBK2	1.58661036
21	NTRK2	1.52494380
22	STK38L	1.48832538
23	PHKG1	1.42319874
24	PHKG2	1.42319874
25	MST4	1.42017010
26	MAP2K6	1.40486408
27	MARK1	1.39302803
28	BRD4	1.36772336
29	TNK2	1.36358499
30	GRK1	1.36188504
31	VRK2	1.31031608
32	WNK3	1.30734516
33	NLK	1.24557512
34	ERBB3	1.18945793
35	DAPK2	1.16500802
36	INSRR	1.09874668
37	MAPKAPK3	1.01615394
38	TLK1	0.95296204
39	MAPK15	0.93703462
40	WNK1	0.93693870
41	FGFR2	0.93613637
42	EIF2AK3	0.92743696
43	DYRK2	0.90460699
44	CDK3	0.85690370
45	CLK1	0.81306988
46	MAP3K4	0.79677711
47	NME1	0.78083215
48	MUSK	0.77106381
49	VRK1	0.73904345
50	MATK	0.70999630
51	MKNK2	0.70927072
52	CDK19	0.69981016
53	FES	0.69092888
54	CAMK1G	0.67822547
55	NTRK1	0.65203601
56	PRKCQ	0.62232107
57	SIK2	0.62187076
58	TRPM7	0.62030666
59	OBSCN	0.58469467
60	MAP2K7	0.57772004
61	CSNK1G1	0.57090803
62	PRKCG	0.56899443
63	STK11	0.55331480
64	PLK3	0.54746045
65	PAK3	0.53001514
66	MAPKAPK5	0.52080857
67	PRKCE	0.50695172
68	RPS6KB1	0.46783087
69	MKNK1	0.46469060
70	PRKG1	0.45810293
71	CSNK1G2	0.45100379
72	TEC	0.44407449
73	CAMK1	0.43292157
74	SGK1	0.42902011
75	ADRBK1	0.42243370
76	ATM	0.42093912
77	KIT	0.41806692
78	CSNK1G3	0.40424493
79	TYRO3	0.38512149
80	STK3	0.37708799
81	CSNK1D	0.36959164
82	EPHA4	0.36489021
83	MAP3K2	0.35847102
84	SGK2	0.35805647
85	WEE1	0.35771627
86	CSNK1E	0.35757022
87	TGFBR2	0.35570798
88	PLK1	0.33960315
89	FGFR3	0.33516732
90	PKN1	0.32792686
91	IKBKB	0.31825136
92	RPS6KA4	0.31591197
93	DYRK1A	0.31563183
94	UHMK1	0.30632252
95	CSNK1A1	0.30127279
96	PIK3CG	0.30122828
97	GRK5	0.29801974
98	MINK1	0.29532727
99	LATS1	0.29011041
100	PRKACA	0.28992145

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.36628441
2	Phototransduction_Homo sapiens_hsa04744	3.10944711
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.64271007
4	Olfactory transduction_Homo sapiens_hsa04740	2.51225772
5	Asthma_Homo sapiens_hsa05310	2.25368479
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.20948931
7	Basal transcription factors_Homo sapiens_hsa03022	2.06958251
8	Nicotine addiction_Homo sapiens_hsa05033	1.96536215
9	Fanconi anemia pathway_Homo sapiens_hsa03460	1.94147792
10	Butanoate metabolism_Homo sapiens_hsa00650	1.93483338
11	Homologous recombination_Homo sapiens_hsa03440	1.87416842
12	Allograft rejection_Homo sapiens_hsa05330	1.86167831
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.79679302
14	One carbon pool by folate_Homo sapiens_hsa00670	1.76333729
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75790552
16	RNA polymerase_Homo sapiens_hsa03020	1.74840665
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.72373761
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70286597
19	Taste transduction_Homo sapiens_hsa04742	1.66796794
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64115007
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55225395
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54415420
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54112501
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51662469
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.50411172
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45785734
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42163915
28	Salivary secretion_Homo sapiens_hsa04970	1.33148264
29	Propanoate metabolism_Homo sapiens_hsa00640	1.31853301
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.31203048
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.29465864
32	Caffeine metabolism_Homo sapiens_hsa00232	1.28429829
33	RNA degradation_Homo sapiens_hsa03018	1.24234445
34	RNA transport_Homo sapiens_hsa03013	1.22143508
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.16884654
36	Regulation of autophagy_Homo sapiens_hsa04140	1.14621998
37	Purine metabolism_Homo sapiens_hsa00230	1.14046987
38	Renin secretion_Homo sapiens_hsa04924	1.13857618
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.13479964
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10370229
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.10163444
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.09842814
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09610355
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06756236
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.06584867
46	Circadian entrainment_Homo sapiens_hsa04713	1.06438011
47	Mismatch repair_Homo sapiens_hsa03430	1.05023244
48	Tryptophan metabolism_Homo sapiens_hsa00380	1.03063296
49	Protein export_Homo sapiens_hsa03060	1.00072230
50	Insulin secretion_Homo sapiens_hsa04911	0.97068103
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94313147
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.92364038
53	Morphine addiction_Homo sapiens_hsa05032	0.87083334
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86845393
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84609320
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84406889
57	Retinol metabolism_Homo sapiens_hsa00830	0.83431528
58	Peroxisome_Homo sapiens_hsa04146	0.80413648
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79714555
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79020403
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78829279
62	Proteasome_Homo sapiens_hsa03050	0.76695992
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.74466000
64	Serotonergic synapse_Homo sapiens_hsa04726	0.72891809
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72743772
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.69447482
67	Long-term depression_Homo sapiens_hsa04730	0.68735662
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66612184
69	GABAergic synapse_Homo sapiens_hsa04727	0.65864639
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65599839
71	Fatty acid elongation_Homo sapiens_hsa00062	0.64181708
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63204307
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62575670
74	Amphetamine addiction_Homo sapiens_hsa05031	0.62092618
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.61449843
76	Huntingtons disease_Homo sapiens_hsa05016	0.60039663
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.58410312
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54981856
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.54475204
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53961547
81	ABC transporters_Homo sapiens_hsa02010	0.53221107
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.52146611
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51325094
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48634686
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47311948
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46775736
87	Long-term potentiation_Homo sapiens_hsa04720	0.45202550
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45127598
89	Spliceosome_Homo sapiens_hsa03040	0.44473717
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44051933
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43913181
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.42360856
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42137013
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42053833
95	Metabolic pathways_Homo sapiens_hsa01100	0.41386348
96	Oocyte meiosis_Homo sapiens_hsa04114	0.40921377
97	Fatty acid degradation_Homo sapiens_hsa00071	0.40784635
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39819739
99	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39361989
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.38630623

NPIPA5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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