ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.05325424
2	establishment of protein localization to Golgi (GO:0072600)	5.44908012
3	protein targeting to Golgi (GO:0000042)	5.43140522
4	rRNA methylation (GO:0031167)	5.21487183
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.20292711
6	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.88017523
7	sperm motility (GO:0030317)	4.69482278
8	cilium or flagellum-dependent cell motility (GO:0001539)	4.58080143
9	rRNA modification (GO:0000154)	4.54679749
10	protein localization to Golgi apparatus (GO:0034067)	4.41307582
11	axoneme assembly (GO:0035082)	4.39322245
12	cellular ketone body metabolic process (GO:0046950)	4.38455755
13	epithelial cilium movement (GO:0003351)	4.26787631
14	regulation of meiosis I (GO:0060631)	4.23413878
15	regulation of cilium movement (GO:0003352)	4.19012308
16	single strand break repair (GO:0000012)	3.88087419
17	axonemal dynein complex assembly (GO:0070286)	3.86465860
18	synapsis (GO:0007129)	3.81657285
19	ketone body metabolic process (GO:1902224)	3.79602962
20	cilium movement (GO:0003341)	3.68552539
21	acrosome reaction (GO:0007340)	3.67377685
22	regulation of hexokinase activity (GO:1903299)	3.66864941
23	regulation of glucokinase activity (GO:0033131)	3.66864941
24	fusion of sperm to egg plasma membrane (GO:0007342)	3.66766580
25	cell wall macromolecule catabolic process (GO:0016998)	3.63122212
26	protein polyglutamylation (GO:0018095)	3.52793597
27	piRNA metabolic process (GO:0034587)	3.51210901
28	positive regulation of glycolytic process (GO:0045821)	3.49854766
29	L-fucose catabolic process (GO:0042355)	3.44714090
30	fucose catabolic process (GO:0019317)	3.44714090
31	L-fucose metabolic process (GO:0042354)	3.44714090
32	platelet dense granule organization (GO:0060155)	3.31766086
33	microtubule nucleation (GO:0007020)	3.25777606
34	DNA methylation involved in gamete generation (GO:0043046)	3.25269101
35	sperm-egg recognition (GO:0035036)	3.25125445
36	multicellular organism reproduction (GO:0032504)	3.22421668
37	spermatid development (GO:0007286)	3.19569038
38	brain morphogenesis (GO:0048854)	3.18881688
39	nephron tubule morphogenesis (GO:0072078)	3.17600929
40	nephron epithelium morphogenesis (GO:0072088)	3.17600929
41	DNA double-strand break processing (GO:0000729)	3.16576151
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.13514811
43	male meiosis (GO:0007140)	3.13419929
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.11828684
45	indole-containing compound catabolic process (GO:0042436)	3.09201687
46	indolalkylamine catabolic process (GO:0046218)	3.09201687
47	tryptophan catabolic process (GO:0006569)	3.09201687
48	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03773761
49	C4-dicarboxylate transport (GO:0015740)	3.01857346
50	retinal cone cell development (GO:0046549)	3.00317049
51	cell wall macromolecule metabolic process (GO:0044036)	2.99248595
52	tryptophan metabolic process (GO:0006568)	2.96787930
53	phosphatidylethanolamine metabolic process (GO:0046337)	2.93152782
54	intra-Golgi vesicle-mediated transport (GO:0006891)	2.89356968
55	centriole replication (GO:0007099)	2.87691917
56	retinal rod cell development (GO:0046548)	2.85204649
57	positive regulation of meiosis (GO:0045836)	2.84242500
58	negative regulation of Rho protein signal transduction (GO:0035024)	2.78398067
59	RNA destabilization (GO:0050779)	2.77897446
60	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.76283080
61	plasma membrane fusion (GO:0045026)	2.74750633
62	cell-cell recognition (GO:0009988)	2.74468576
63	indolalkylamine metabolic process (GO:0006586)	2.71850119
64	mannosylation (GO:0097502)	2.71292551
65	adenosine metabolic process (GO:0046085)	2.69128323
66	sperm capacitation (GO:0048240)	2.66609766
67	positive regulation of meiotic cell cycle (GO:0051446)	2.65944128
68	cilium organization (GO:0044782)	2.65617651
69	renal tubule morphogenesis (GO:0061333)	2.63402562
70	photoreceptor cell maintenance (GO:0045494)	2.62113485
71	resolution of meiotic recombination intermediates (GO:0000712)	2.61162518
72	spermatogenesis (GO:0007283)	2.60705511
73	S-adenosylmethionine metabolic process (GO:0046500)	2.60609442
74	water-soluble vitamin biosynthetic process (GO:0042364)	2.60075148
75	male gamete generation (GO:0048232)	2.59684981
76	microtubule severing (GO:0051013)	2.58691969
77	regulation of microtubule-based movement (GO:0060632)	2.58110976
78	regulation of centriole replication (GO:0046599)	2.57482020
79	acrosome assembly (GO:0001675)	2.56742846
80	microtubule depolymerization (GO:0007019)	2.55434918
81	cilium assembly (GO:0042384)	2.52598953
82	cilium morphogenesis (GO:0060271)	2.48699356
83	binding of sperm to zona pellucida (GO:0007339)	2.47486026
84	nonmotile primary cilium assembly (GO:0035058)	2.46759056
85	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.46593518
86	protein-cofactor linkage (GO:0018065)	2.45752174
87	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.44982889
88	gamma-aminobutyric acid transport (GO:0015812)	2.44472460
89	organic cation transport (GO:0015695)	2.44151281
90	ubiquinone biosynthetic process (GO:0006744)	2.44066437
91	gamete generation (GO:0007276)	2.44042082
92	spermatid nucleus differentiation (GO:0007289)	2.43950531
93	short-chain fatty acid metabolic process (GO:0046459)	2.43482371
94	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.42844456
95	isotype switching (GO:0045190)	2.42844456
96	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.42844456
97	neuronal action potential (GO:0019228)	2.42263069
98	reproduction (GO:0000003)	2.42254494
99	regulation of telomere maintenance (GO:0032204)	2.41730195
100	regulation of DNA endoreduplication (GO:0032875)	2.40535406

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.81721092
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44241323
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.24512556
4	FUS_26573619_Chip-Seq_HEK293_Human	2.79614883
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.71176411
6	VDR_22108803_ChIP-Seq_LS180_Human	2.58967534
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56597427
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54124266
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.45380732
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34698793
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29578519
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28132256
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.24974250
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.22006435
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.16222761
16	P300_19829295_ChIP-Seq_ESCs_Human	2.11892152
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11451939
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.98631474
19	EWS_26573619_Chip-Seq_HEK293_Human	1.97621552
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.96218301
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.96218301
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96084824
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88921561
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83987657
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76877325
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76746301
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71772607
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.70057572
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69507293
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.64837486
31	STAT3_23295773_ChIP-Seq_U87_Human	1.64259841
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64120845
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62320013
34	AR_25329375_ChIP-Seq_VCAP_Human	1.60506662
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59135523
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58492176
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.57744770
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56999847
39	TCF4_22108803_ChIP-Seq_LS180_Human	1.55076692
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.54046884
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53739785
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.52959429
43	TCF4_23295773_ChIP-Seq_U87_Human	1.51799814
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51345164
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47337189
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45364067
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45364067
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.44266241
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43629988
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40476689
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40129534
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.35571332
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.34092461
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32112996
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31236596
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30169534
57	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28763404
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26847820
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23010585
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21633890
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21454490
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21454490
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20258224
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19540574
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15352609
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15035441
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14664301
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12517115
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12294175
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11530301
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11530301
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10949201
73	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10523158
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10099700
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10051976
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.09887040
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09488357
78	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09365638
79	NCOR_22424771_ChIP-Seq_293T_Human	1.09340544
80	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.09036587
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08825468
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08016459
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07818008
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06462751
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06459153
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05598678
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04315472
88	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02956154
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02867325
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02017522
91	KDM2B_26808549_Chip-Seq_REH_Human	1.01873864
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01794757
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00805014
94	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00368694
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.99177446
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98870327
97	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.97255375
98	JUN_21703547_ChIP-Seq_K562_Human	0.96238800
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96208471
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94981869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.69923020
2	MP0008877_abnormal_DNA_methylation	3.15520935
3	MP0000569_abnormal_digit_pigmentation	3.08278111
4	MP0003195_calcinosis	2.81999064
5	MP0002138_abnormal_hepatobiliary_system	2.39648722
6	MP0008995_early_reproductive_senescence	2.30752191
7	MP0005646_abnormal_pituitary_gland	2.25511665
8	MP0005551_abnormal_eye_electrophysiolog	2.17552782
9	MP0004043_abnormal_pH_regulation	2.07211218
10	MP0003136_yellow_coat_color	1.91871814
11	MP0003698_abnormal_male_reproductive	1.84832102
12	MP0002735_abnormal_chemical_nociception	1.83996040
13	MP0001929_abnormal_gametogenesis	1.82507586
14	MP0001968_abnormal_touch/_nociception	1.79740682
15	MP0002254_reproductive_system_inflammat	1.75266805
16	MP0005174_abnormal_tail_pigmentation	1.74005860
17	MP0005367_renal/urinary_system_phenotyp	1.70974380
18	MP0000516_abnormal_urinary_system	1.70974380
19	MP0005645_abnormal_hypothalamus_physiol	1.70433784
20	MP0003718_maternal_effect	1.70140940
21	MP0006054_spinal_hemorrhage	1.68470040
22	MP0003172_abnormal_lysosome_physiology	1.65559850
23	MP0001984_abnormal_olfaction	1.64799909
24	MP0002102_abnormal_ear_morphology	1.60371533
25	MP0006292_abnormal_olfactory_placode	1.59241138
26	MP0009780_abnormal_chondrocyte_physiolo	1.58066674
27	MP0008058_abnormal_DNA_repair	1.51564676
28	MP0008872_abnormal_physiological_respon	1.49405084
29	MP0008875_abnormal_xenobiotic_pharmacok	1.47498981
30	MP0003878_abnormal_ear_physiology	1.46169798
31	MP0005377_hearing/vestibular/ear_phenot	1.46169798
32	MP0001485_abnormal_pinna_reflex	1.44894698
33	MP0000013_abnormal_adipose_tissue	1.44016201
34	MP0002653_abnormal_ependyma_morphology	1.43269753
35	MP0004885_abnormal_endolymph	1.40902256
36	MP0002837_dystrophic_cardiac_calcinosis	1.35226558
37	MP0001529_abnormal_vocalization	1.34764052
38	MP0001486_abnormal_startle_reflex	1.34357798
39	MP0004742_abnormal_vestibular_system	1.29897385
40	MP0006072_abnormal_retinal_apoptosis	1.29722627
41	MP0005379_endocrine/exocrine_gland_phen	1.28747161
42	MP0003122_maternal_imprinting	1.27734405
43	MP0002210_abnormal_sex_determination	1.25872324
44	MP0009384_cardiac_valve_regurgitation	1.24285551
45	MP0003786_premature_aging	1.23965185
46	MP0002272_abnormal_nervous_system	1.23213383
47	MP0003011_delayed_dark_adaptation	1.22766574
48	MP0005253_abnormal_eye_physiology	1.21368177
49	MP0001501_abnormal_sleep_pattern	1.21196043
50	MP0005332_abnormal_amino_acid	1.18630302
51	MP0005360_urolithiasis	1.18274217
52	MP0002229_neurodegeneration	1.18052759
53	MP0002736_abnormal_nociception_after	1.17774577
54	MP0000653_abnormal_sex_gland	1.17206106
55	MP0002938_white_spotting	1.16330618
56	MP0003121_genomic_imprinting	1.15870293
57	MP0002282_abnormal_trachea_morphology	1.12564642
58	MP0002928_abnormal_bile_duct	1.10960912
59	MP0003880_abnormal_central_pattern	1.10767065
60	MP0001145_abnormal_male_reproductive	1.08461512
61	MP0005085_abnormal_gallbladder_physiolo	1.08233682
62	MP0002160_abnormal_reproductive_system	1.07202055
63	MP0005084_abnormal_gallbladder_morpholo	1.06040708
64	MP0001764_abnormal_homeostasis	1.04271752
65	MP0002751_abnormal_autonomic_nervous	1.02958897
66	MP0009046_muscle_twitch	1.02232399
67	MP0005636_abnormal_mineral_homeostasis	1.01239404
68	MP0005365_abnormal_bile_salt	1.01062732
69	MP0002876_abnormal_thyroid_physiology	0.99315245
70	MP0009745_abnormal_behavioral_response	0.99028479
71	MP0002139_abnormal_hepatobiliary_system	0.98894109
72	MP0000015_abnormal_ear_pigmentation	0.97952156
73	MP0005220_abnormal_exocrine_pancreas	0.96362717
74	MP0004142_abnormal_muscle_tone	0.96053041
75	MP0002638_abnormal_pupillary_reflex	0.95915520
76	MP0010386_abnormal_urinary_bladder	0.95579558
77	MP0010329_abnormal_lipoprotein_level	0.93871439
78	MP0000538_abnormal_urinary_bladder	0.93367242
79	MP0002234_abnormal_pharynx_morphology	0.92093896
80	MP0001944_abnormal_pancreas_morphology	0.90828793
81	MP0000427_abnormal_hair_cycle	0.90376467
82	MP0001963_abnormal_hearing_physiology	0.89028405
83	MP0001666_abnormal_nutrient_absorption	0.87201006
84	MP0002161_abnormal_fertility/fecundity	0.87152451
85	MP0004270_analgesia	0.86650022
86	MP0000372_irregular_coat_pigmentation	0.85980380
87	MP0003646_muscle_fatigue	0.85621599
88	MP0004019_abnormal_vitamin_homeostasis	0.85121833
89	MP0002734_abnormal_mechanical_nocicepti	0.84866317
90	MP0002184_abnormal_innervation	0.84265127
91	MP0005075_abnormal_melanosome_morpholog	0.83020618
92	MP0001765_abnormal_ion_homeostasis	0.82667891
93	MP0003943_abnormal_hepatobiliary_system	0.82497852
94	MP0002572_abnormal_emotion/affect_behav	0.82228741
95	MP0000631_abnormal_neuroendocrine_gland	0.81893564
96	MP0003252_abnormal_bile_duct	0.81405699
97	MP0002557_abnormal_social/conspecific_i	0.79785645
98	MP0002067_abnormal_sensory_capabilities	0.79587858
99	MP0001270_distended_abdomen	0.79046032
100	MP0000383_abnormal_hair_follicle	0.78814816

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	5.47072659
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.79228994
3	Absent/shortened dynein arms (HP:0200106)	4.79228994
4	Nephronophthisis (HP:0000090)	4.04266638
5	Chronic hepatic failure (HP:0100626)	4.03193456
6	Abnormality of the renal medulla (HP:0100957)	3.67603944
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.65697928
8	Abnormality of the renal cortex (HP:0011035)	3.45592571
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.34507701
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.34507701
11	Pancreatic cysts (HP:0001737)	3.32086436
12	Tubular atrophy (HP:0000092)	3.16964813
13	True hermaphroditism (HP:0010459)	3.15508098
14	Molar tooth sign on MRI (HP:0002419)	3.08067823
15	Abnormality of midbrain morphology (HP:0002418)	3.08067823
16	Pancreatic fibrosis (HP:0100732)	3.04998992
17	Severe visual impairment (HP:0001141)	3.01297891
18	Volvulus (HP:0002580)	2.95581189
19	Abnormal ciliary motility (HP:0012262)	2.94884962
20	Tubulointerstitial abnormality (HP:0001969)	2.88336851
21	Attenuation of retinal blood vessels (HP:0007843)	2.87143886
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.71465188
23	Renal cortical cysts (HP:0000803)	2.64112930
24	Focal motor seizures (HP:0011153)	2.51030310
25	Intestinal atresia (HP:0011100)	2.49430089
26	Cystic liver disease (HP:0006706)	2.46629929
27	Azoospermia (HP:0000027)	2.44602990
28	Methylmalonic acidemia (HP:0002912)	2.41056508
29	Ketoacidosis (HP:0001993)	2.40951946
30	Medial flaring of the eyebrow (HP:0010747)	2.34365540
31	Abnormal respiratory motile cilium physiology (HP:0012261)	2.32440931
32	Thyroiditis (HP:0100646)	2.32145228
33	Abnormality of the nasal septum (HP:0000419)	2.29268250
34	Congenital stationary night blindness (HP:0007642)	2.29187422
35	Congenital sensorineural hearing impairment (HP:0008527)	2.17816363
36	Progressive cerebellar ataxia (HP:0002073)	2.17698376
37	Abnormal drinking behavior (HP:0030082)	2.15266808
38	Polydipsia (HP:0001959)	2.15266808
39	Stage 5 chronic kidney disease (HP:0003774)	2.10502084
40	Hypoplastic ischia (HP:0003175)	2.10228950
41	Increased corneal curvature (HP:0100692)	2.08616505
42	Keratoconus (HP:0000563)	2.08616505
43	Hyperglycinuria (HP:0003108)	2.07726461
44	Pendular nystagmus (HP:0012043)	2.07088077
45	Abnormal biliary tract physiology (HP:0012439)	2.06690612
46	Bile duct proliferation (HP:0001408)	2.06690612
47	Ketosis (HP:0001946)	2.06444418
48	Occipital encephalocele (HP:0002085)	2.02316796
49	Hyperglycinemia (HP:0002154)	2.02268449
50	Hyperkalemia (HP:0002153)	2.01771941
51	Abnormality of vitamin B metabolism (HP:0004340)	2.01054295
52	Abolished electroretinogram (ERG) (HP:0000550)	2.00400788
53	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99927731
54	Abnormality of glycine metabolism (HP:0010895)	1.99927731
55	Chorioretinal atrophy (HP:0000533)	1.99562506
56	Delayed CNS myelination (HP:0002188)	1.98526719
57	Arthropathy (HP:0003040)	1.97562425
58	Oligodactyly (hands) (HP:0001180)	1.96887264
59	Febrile seizures (HP:0002373)	1.95536473
60	Severe combined immunodeficiency (HP:0004430)	1.94301402
61	Postaxial foot polydactyly (HP:0001830)	1.93963794
62	Gaze-evoked nystagmus (HP:0000640)	1.93911999
63	Gastrointestinal atresia (HP:0002589)	1.93870026
64	Type II lissencephaly (HP:0007260)	1.92609629
65	Abnormality of macular pigmentation (HP:0008002)	1.92155143
66	Ependymoma (HP:0002888)	1.89955911
67	Hyperventilation (HP:0002883)	1.89475677
68	Congenital hepatic fibrosis (HP:0002612)	1.83868495
69	Methylmalonic aciduria (HP:0012120)	1.83769950
70	Abnormality of the pancreatic islet cells (HP:0006476)	1.81234173
71	Abnormality of endocrine pancreas physiology (HP:0012093)	1.81234173
72	Nephrogenic diabetes insipidus (HP:0009806)	1.80787903
73	Hypothermia (HP:0002045)	1.80463220
74	Hemiparesis (HP:0001269)	1.80345480
75	Abnormal spermatogenesis (HP:0008669)	1.80256675
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79626285
77	Albinism (HP:0001022)	1.79119577
78	Horizontal nystagmus (HP:0000666)	1.78501920
79	Enlarged epiphyses (HP:0010580)	1.78163000
80	Constricted visual fields (HP:0001133)	1.75231844
81	Bulbous nose (HP:0000414)	1.72233199
82	Astrocytoma (HP:0009592)	1.71672540
83	Abnormality of the astrocytes (HP:0100707)	1.71672540
84	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.71454074
85	Abnormality of the ischium (HP:0003174)	1.71412073
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71391804
87	Abnormal biliary tract morphology (HP:0012440)	1.71317319
88	Cone-rod dystrophy (HP:0000548)	1.71046469
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.70425807
90	Broad-based gait (HP:0002136)	1.70313341
91	Glioma (HP:0009733)	1.69454281
92	Supernumerary spleens (HP:0009799)	1.68742143
93	Portal hypertension (HP:0001409)	1.68726776
94	Congenital primary aphakia (HP:0007707)	1.68393904
95	Narrow forehead (HP:0000341)	1.66484978
96	Infertility (HP:0000789)	1.66026168
97	Large for gestational age (HP:0001520)	1.65843712
98	Widely spaced teeth (HP:0000687)	1.64135139
99	Abnormality of urine glucose concentration (HP:0011016)	1.64109994
100	Glycosuria (HP:0003076)	1.64109994

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.80030217
2	MAP4K2	4.21060795
3	FRK	3.79975529
4	WNK4	3.30018743
5	MAPK15	3.26067141
6	INSRR	2.55096841
7	PLK4	2.37363565
8	STK39	2.25065361
9	BMPR1B	2.23313374
10	MKNK2	1.96356410
11	EIF2AK3	1.93925675
12	TNIK	1.88650325
13	WNK3	1.84802729
14	PLK2	1.77776772
15	TSSK6	1.75088009
16	FGFR2	1.71130487
17	NUAK1	1.66206866
18	WNK1	1.65041044
19	ADRBK2	1.64796874
20	CAMK1G	1.64503934
21	BRD4	1.53989591
22	NME1	1.51167293
23	TAOK3	1.47117425
24	ACVR1B	1.43678694
25	CDK3	1.43214652
26	PINK1	1.39479816
27	GRK1	1.39116170
28	NLK	1.29104513
29	VRK1	1.25260965
30	NTRK3	1.19343302
31	MAPKAPK3	1.18400628
32	AKT3	1.16525081
33	MKNK1	1.16497639
34	OXSR1	1.11675211
35	MAPK13	1.08796049
36	STK38L	0.98901914
37	PHKG2	0.98702176
38	PHKG1	0.98702176
39	BCKDK	0.97418396
40	MAP3K4	0.95173224
41	VRK2	0.94825933
42	MAP2K6	0.93758692
43	FER	0.93543205
44	BRSK2	0.91749980
45	PRKCE	0.88095425
46	PLK3	0.87753038
47	PAK3	0.83233428
48	EPHA3	0.80877220
49	FGFR3	0.79166009
50	EIF2AK1	0.76437177
51	PRKCG	0.74480362
52	CASK	0.72879465
53	TAF1	0.71602262
54	MET	0.71485118
55	MUSK	0.70002262
56	DDR2	0.69213159
57	TRIM28	0.69198330
58	MAP3K2	0.66675007
59	PTK2B	0.66180531
60	NTRK2	0.65177961
61	TGFBR1	0.59793602
62	WEE1	0.53838433
63	ERBB2	0.51755359
64	MAPKAPK5	0.51188258
65	ERBB3	0.48973843
66	BCR	0.48111440
67	TNK2	0.47694478
68	PRKAA2	0.46921460
69	FGFR1	0.45778850
70	IRAK1	0.45400282
71	DAPK2	0.44676659
72	YES1	0.44498340
73	CSNK1G1	0.44291393
74	LMTK2	0.43724477
75	SGK2	0.43400747
76	ATM	0.42054034
77	PIK3CA	0.41129662
78	KIT	0.41081405
79	PRKG1	0.40311421
80	PIK3CG	0.39124023
81	CAMK1	0.38646060
82	MST4	0.38551994
83	TXK	0.37280556
84	ADRBK1	0.36841024
85	IGF1R	0.36679779
86	CDK9	0.34951874
87	PRKCQ	0.33321054
88	ZAK	0.33115714
89	CDK8	0.32953527
90	PRKCZ	0.32565503
91	MAP3K7	0.32113932
92	PRKCI	0.31713299
93	RPS6KB1	0.31639436
94	FLT3	0.31443519
95	ITK	0.31030136
96	TEC	0.30267411
97	MARK1	0.30151973
98	CSNK1E	0.28140196
99	CSNK1D	0.26701982
100	MST1R	0.25412920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.23765129
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.11003729
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.97920663
4	Butanoate metabolism_Homo sapiens_hsa00650	2.84894376
5	Protein export_Homo sapiens_hsa03060	2.59287982
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.45084596
7	Propanoate metabolism_Homo sapiens_hsa00640	2.35267106
8	One carbon pool by folate_Homo sapiens_hsa00670	2.34515470
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.29785225
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25247999
11	RNA polymerase_Homo sapiens_hsa03020	2.17487345
12	Phototransduction_Homo sapiens_hsa04744	1.96803414
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86953346
14	Basal transcription factors_Homo sapiens_hsa03022	1.82224701
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.70807607
16	Taste transduction_Homo sapiens_hsa04742	1.68661016
17	Caffeine metabolism_Homo sapiens_hsa00232	1.68232607
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66601503
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.57920699
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.55304741
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48387174
22	RNA degradation_Homo sapiens_hsa03018	1.41982387
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.41011317
24	RNA transport_Homo sapiens_hsa03013	1.38954278
25	Olfactory transduction_Homo sapiens_hsa04740	1.33565190
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.33032995
27	Homologous recombination_Homo sapiens_hsa03440	1.29686284
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26574394
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23582060
30	Peroxisome_Homo sapiens_hsa04146	1.22823236
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20275421
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19756706
33	Regulation of autophagy_Homo sapiens_hsa04140	1.17333117
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15991076
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.15648616
36	Retinol metabolism_Homo sapiens_hsa00830	1.14559071
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.13507666
38	Insulin secretion_Homo sapiens_hsa04911	1.13471341
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.07754069
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06173282
41	Type I diabetes mellitus_Homo sapiens_hsa04940	1.05563214
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.99885572
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97834439
44	Salivary secretion_Homo sapiens_hsa04970	0.96942112
45	Purine metabolism_Homo sapiens_hsa00230	0.94415097
46	ABC transporters_Homo sapiens_hsa02010	0.94063773
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86842404
48	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.85726922
49	Nicotine addiction_Homo sapiens_hsa05033	0.85712907
50	Oocyte meiosis_Homo sapiens_hsa04114	0.83592265
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83317618
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.80342515
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79378322
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.79233721
55	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77863508
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75071565
57	Mineral absorption_Homo sapiens_hsa04978	0.74767875
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.73543560
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72708222
60	Sulfur metabolism_Homo sapiens_hsa00920	0.72103859
61	Fatty acid elongation_Homo sapiens_hsa00062	0.71723672
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71147881
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.70566793
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.68727038
65	Allograft rejection_Homo sapiens_hsa05330	0.66841672
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66577623
67	Circadian entrainment_Homo sapiens_hsa04713	0.65024414
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64975476
69	GABAergic synapse_Homo sapiens_hsa04727	0.63407672
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63298924
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63057883
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62905327
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60943401
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60824871
75	Renin secretion_Homo sapiens_hsa04924	0.59313865
76	Metabolic pathways_Homo sapiens_hsa01100	0.59260506
77	Serotonergic synapse_Homo sapiens_hsa04726	0.56837028
78	Fatty acid degradation_Homo sapiens_hsa00071	0.56734469
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53074726
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52393744
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51242420
82	Complement and coagulation cascades_Homo sapiens_hsa04610	0.50905769
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50276705
84	Pancreatic secretion_Homo sapiens_hsa04972	0.50024348
85	Asthma_Homo sapiens_hsa05310	0.48363580
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47251452
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45508594
88	Morphine addiction_Homo sapiens_hsa05032	0.43957140
89	Amphetamine addiction_Homo sapiens_hsa05031	0.42519734
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41361124
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40551890
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.40346778
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39732621
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.38610698
95	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38588080
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38066863
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37937471
98	Lysine degradation_Homo sapiens_hsa00310	0.37867052
99	Protein digestion and absorption_Homo sapiens_hsa04974	0.37692543
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37161776

NPIPA7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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