ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	3.51302483
2	regulation of hexokinase activity (GO:1903299)	3.49444399
3	regulation of glucokinase activity (GO:0033131)	3.49444399
4	neuronal action potential propagation (GO:0019227)	3.38458257
5	DNA deamination (GO:0045006)	3.38124730
6	presynaptic membrane organization (GO:0097090)	3.37337383
7	DNA double-strand break processing (GO:0000729)	3.35022157
8	protein complex biogenesis (GO:0070271)	3.31829659
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31322572
10	regulation of cilium movement (GO:0003352)	3.26716733
11	epithelial cilium movement (GO:0003351)	3.25581699
12	neuron fate determination (GO:0048664)	3.22899484
13	inner ear receptor stereocilium organization (GO:0060122)	3.22678215
14	L-fucose catabolic process (GO:0042355)	3.22383735
15	fucose catabolic process (GO:0019317)	3.22383735
16	L-fucose metabolic process (GO:0042354)	3.22383735
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.20262386
18	nonmotile primary cilium assembly (GO:0035058)	3.19054978
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12430232
20	cellular ketone body metabolic process (GO:0046950)	3.09647899
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.09605614
22	positive regulation of meiosis (GO:0045836)	3.06480128
23	respiratory chain complex IV assembly (GO:0008535)	3.06123773
24	gamma-aminobutyric acid transport (GO:0015812)	3.06075951
25	protein-cofactor linkage (GO:0018065)	3.05756947
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02926747
27	NADH dehydrogenase complex assembly (GO:0010257)	3.02926747
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02926747
29	postsynaptic membrane organization (GO:0001941)	3.02772827
30	inositol phosphate catabolic process (GO:0071545)	2.99464330
31	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98347571
32	axoneme assembly (GO:0035082)	2.98158722
33	kidney morphogenesis (GO:0060993)	2.93323947
34	response to pheromone (GO:0019236)	2.90401590
35	pyrimidine nucleobase catabolic process (GO:0006208)	2.89464704
36	protein localization to cilium (GO:0061512)	2.88812841
37	platelet dense granule organization (GO:0060155)	2.88780338
38	positive regulation of meiotic cell cycle (GO:0051446)	2.88513809
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87712801
40	replication fork processing (GO:0031297)	2.86264500
41	neuron cell-cell adhesion (GO:0007158)	2.85166917
42	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.83923385
43	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.83680542
44	C4-dicarboxylate transport (GO:0015740)	2.79849630
45	otic vesicle formation (GO:0030916)	2.79783199
46	cytochrome complex assembly (GO:0017004)	2.78052409
47	ketone body metabolic process (GO:1902224)	2.76907183
48	piRNA metabolic process (GO:0034587)	2.76799831
49	regulation of timing of cell differentiation (GO:0048505)	2.76658873
50	serotonin receptor signaling pathway (GO:0007210)	2.72398019
51	nucleobase catabolic process (GO:0046113)	2.72111236
52	cilium movement (GO:0003341)	2.71662270
53	regulation of meiosis I (GO:0060631)	2.70271417
54	intraciliary transport (GO:0042073)	2.67493589
55	cilium morphogenesis (GO:0060271)	2.67469714
56	startle response (GO:0001964)	2.65319846
57	adaptation of signaling pathway (GO:0023058)	2.65227323
58	polyol catabolic process (GO:0046174)	2.63463241
59	auditory receptor cell stereocilium organization (GO:0060088)	2.62549702
60	limb bud formation (GO:0060174)	2.57028792
61	neural tube formation (GO:0001841)	2.56505918
62	prenylation (GO:0097354)	2.55985479
63	protein prenylation (GO:0018342)	2.55985479
64	dendritic spine morphogenesis (GO:0060997)	2.53673628
65	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51339056
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51337752
67	behavioral response to nicotine (GO:0035095)	2.50188849
68	regulation of development, heterochronic (GO:0040034)	2.50120411
69	neuronal action potential (GO:0019228)	2.49169019
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.48650612
71	cullin deneddylation (GO:0010388)	2.46992977
72	indolalkylamine metabolic process (GO:0006586)	2.46773937
73	cilium organization (GO:0044782)	2.46571989
74	adenosine metabolic process (GO:0046085)	2.44918245
75	regulation of microtubule-based movement (GO:0060632)	2.43413258
76	protein polyglutamylation (GO:0018095)	2.42674452
77	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42505450
78	inositol phosphate dephosphorylation (GO:0046855)	2.42505450
79	behavioral response to ethanol (GO:0048149)	2.41538034
80	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.40897945
81	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40810578
82	negative regulation of dendrite development (GO:2000171)	2.40689570
83	cilium assembly (GO:0042384)	2.40129592
84	behavioral defense response (GO:0002209)	2.39425194
85	behavioral fear response (GO:0001662)	2.39425194
86	negative regulation of telomere maintenance (GO:0032205)	2.39279725
87	tryptophan catabolic process (GO:0006569)	2.39069963
88	indole-containing compound catabolic process (GO:0042436)	2.39069963
89	indolalkylamine catabolic process (GO:0046218)	2.39069963
90	resolution of meiotic recombination intermediates (GO:0000712)	2.39043242
91	detection of light stimulus involved in visual perception (GO:0050908)	2.38054997
92	detection of light stimulus involved in sensory perception (GO:0050962)	2.38054997
93	retinal cone cell development (GO:0046549)	2.37636917
94	chaperone-mediated protein transport (GO:0072321)	2.37634024
95	photoreceptor cell development (GO:0042461)	2.37434322
96	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.37199286
97	reflex (GO:0060004)	2.36379796
98	ATP synthesis coupled proton transport (GO:0015986)	2.35842723
99	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.35842723
100	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.35826868

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.28256957
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.02718128
3	VDR_22108803_ChIP-Seq_LS180_Human	2.84153965
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80487964
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53243654
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47074770
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45253116
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.34594507
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.30595362
10	FUS_26573619_Chip-Seq_HEK293_Human	2.28787413
11	EWS_26573619_Chip-Seq_HEK293_Human	2.28242914
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28166889
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24340787
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13253482
15	P300_19829295_ChIP-Seq_ESCs_Human	2.11067395
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06368035
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.05223626
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.04984349
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95047822
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92866067
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90844964
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88584802
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85715114
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.82927479
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78927558
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78780287
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70027885
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.68074643
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66359060
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65096192
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60376632
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60373588
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55801035
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.55090997
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54697763
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52885337
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51256161
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.50906881
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.49097017
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47436619
41	AR_25329375_ChIP-Seq_VCAP_Human	1.46459044
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.45928410
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45646283
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45404217
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.45404217
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45015954
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44736358
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44189508
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43688648
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42390089
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39721507
52	STAT3_23295773_ChIP-Seq_U87_Human	1.38600917
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38309399
54	TCF4_23295773_ChIP-Seq_U87_Human	1.37897754
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37255269
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.34859935
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34589866
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31715777
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31402769
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31014344
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31014344
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29866991
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.29452698
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28582330
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28108357
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27810913
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26643060
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26048407
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26028555
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26028555
71	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25639285
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25103274
73	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25058696
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24966974
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.24042943
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23720537
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23277126
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21962859
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21561003
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18750266
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17926736
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16430293
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14734934
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14230100
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.10109204
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09295768
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09295768
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09083666
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08910993
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07116771
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06370018
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05395006
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03369410
94	JUN_21703547_ChIP-Seq_K562_Human	1.02974786
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02747793
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02308724
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02005830
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01791185
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01598792
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01421189

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.98314259
2	MP0006292_abnormal_olfactory_placode	2.84875475
3	MP0005646_abnormal_pituitary_gland	2.80110252
4	MP0001968_abnormal_touch/_nociception	2.69949098
5	MP0008877_abnormal_DNA_methylation	2.66927466
6	MP0003787_abnormal_imprinting	2.40981964
7	MP0002102_abnormal_ear_morphology	2.40924430
8	MP0004885_abnormal_endolymph	2.40096166
9	MP0002736_abnormal_nociception_after	2.37520893
10	MP0005551_abnormal_eye_electrophysiolog	2.22111451
11	MP0000372_irregular_coat_pigmentation	2.15548466
12	MP0009745_abnormal_behavioral_response	2.07524713
13	MP0001984_abnormal_olfaction	2.06292061
14	MP0009046_muscle_twitch	2.01999189
15	MP0006072_abnormal_retinal_apoptosis	1.99168842
16	MP0002272_abnormal_nervous_system	1.97323556
17	MP0002837_dystrophic_cardiac_calcinosis	1.89595051
18	MP0001486_abnormal_startle_reflex	1.88098990
19	MP0003195_calcinosis	1.85275925
20	MP0002938_white_spotting	1.79654345
21	MP0000569_abnormal_digit_pigmentation	1.76119496
22	MP0003122_maternal_imprinting	1.75362967
23	MP0006276_abnormal_autonomic_nervous	1.73271481
24	MP0004133_heterotaxia	1.69631921
25	MP0002653_abnormal_ependyma_morphology	1.68900704
26	MP0002064_seizures	1.66296843
27	MP0008872_abnormal_physiological_respon	1.60542997
28	MP0003136_yellow_coat_color	1.60066148
29	MP0001529_abnormal_vocalization	1.59218295
30	MP0000631_abnormal_neuroendocrine_gland	1.58488613
31	MP0003121_genomic_imprinting	1.52258467
32	MP0008875_abnormal_xenobiotic_pharmacok	1.49339372
33	MP0003635_abnormal_synaptic_transmissio	1.48587785
34	MP0005645_abnormal_hypothalamus_physiol	1.47991703
35	MP0002735_abnormal_chemical_nociception	1.44276703
36	MP0004142_abnormal_muscle_tone	1.44065900
37	MP0000778_abnormal_nervous_system	1.43159402
38	MP0002734_abnormal_mechanical_nocicepti	1.41718821
39	MP0002572_abnormal_emotion/affect_behav	1.40566165
40	MP0008789_abnormal_olfactory_epithelium	1.38131146
41	MP0005253_abnormal_eye_physiology	1.37212281
42	MP0010386_abnormal_urinary_bladder	1.36698789
43	MP0002638_abnormal_pupillary_reflex	1.35826615
44	MP0002234_abnormal_pharynx_morphology	1.32678991
45	MP0002063_abnormal_learning/memory/cond	1.31699883
46	MP0004859_abnormal_synaptic_plasticity	1.27738107
47	MP0001970_abnormal_pain_threshold	1.26761337
48	MP0004043_abnormal_pH_regulation	1.26000651
49	MP0002557_abnormal_social/conspecific_i	1.25259724
50	MP0001501_abnormal_sleep_pattern	1.24638193
51	MP0001188_hyperpigmentation	1.24623039
52	MP0001986_abnormal_taste_sensitivity	1.23859442
53	MP0008995_early_reproductive_senescence	1.23633671
54	MP0005084_abnormal_gallbladder_morpholo	1.22637856
55	MP0004147_increased_porphyrin_level	1.19902706
56	MP0009780_abnormal_chondrocyte_physiolo	1.19893865
57	MP0002733_abnormal_thermal_nociception	1.19733320
58	MP0003011_delayed_dark_adaptation	1.17133170
59	MP0004270_analgesia	1.16154342
60	MP0008058_abnormal_DNA_repair	1.14067235
61	MP0005423_abnormal_somatic_nervous	1.13453283
62	MP0002751_abnormal_autonomic_nervous	1.13057294
63	MP0002184_abnormal_innervation	1.12549233
64	MP0000516_abnormal_urinary_system	1.10267391
65	MP0005367_renal/urinary_system_phenotyp	1.10267391
66	MP0002067_abnormal_sensory_capabilities	1.08015304
67	MP0005379_endocrine/exocrine_gland_phen	1.07609090
68	MP0005075_abnormal_melanosome_morpholog	1.06729732
69	MP0002752_abnormal_somatic_nervous	1.05953067
70	MP0001485_abnormal_pinna_reflex	1.05042039
71	MP0000026_abnormal_inner_ear	1.04283596
72	MP0002876_abnormal_thyroid_physiology	1.04002301
73	MP0002160_abnormal_reproductive_system	1.03615046
74	MP0002163_abnormal_gland_morphology	1.02231267
75	MP0005174_abnormal_tail_pigmentation	1.01783122
76	MP0005394_taste/olfaction_phenotype	1.01762815
77	MP0005499_abnormal_olfactory_system	1.01762815
78	MP0005386_behavior/neurological_phenoty	1.01481858
79	MP0004924_abnormal_behavior	1.01481858
80	MP0005195_abnormal_posterior_eye	0.99937870
81	MP0000566_synostosis	0.96625159
82	MP0001764_abnormal_homeostasis	0.95741366
83	MP0002822_catalepsy	0.95236334
84	MP0004742_abnormal_vestibular_system	0.92202355
85	MP0003718_maternal_effect	0.91799926
86	MP0002138_abnormal_hepatobiliary_system	0.91590046
87	MP0001963_abnormal_hearing_physiology	0.89320930
88	MP0005332_abnormal_amino_acid	0.89297460
89	MP0002229_neurodegeneration	0.88561315
90	MP0002928_abnormal_bile_duct	0.87876815
91	MP0000538_abnormal_urinary_bladder	0.86928687
92	MP0002882_abnormal_neuron_morphology	0.86245166
93	MP0001905_abnormal_dopamine_level	0.86119466
94	MP0002233_abnormal_nose_morphology	0.82806336
95	MP0000955_abnormal_spinal_cord	0.81134432
96	MP0003698_abnormal_male_reproductive	0.81097964
97	MP0001944_abnormal_pancreas_morphology	0.80982518
98	MP0001502_abnormal_circadian_rhythm	0.80440407
99	MP0002095_abnormal_skin_pigmentation	0.79916136
100	MP0000427_abnormal_hair_cycle	0.78774819

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.15356643
2	True hermaphroditism (HP:0010459)	4.13012562
3	Focal motor seizures (HP:0011153)	4.03980316
4	Pancreatic fibrosis (HP:0100732)	3.86874191
5	Abnormality of midbrain morphology (HP:0002418)	3.70889961
6	Molar tooth sign on MRI (HP:0002419)	3.70889961
7	Nephronophthisis (HP:0000090)	3.63043975
8	Congenital stationary night blindness (HP:0007642)	3.33782457
9	Acute necrotizing encephalopathy (HP:0006965)	3.13240490
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.13169521
11	Hypothermia (HP:0002045)	3.04258732
12	Abnormality of the renal medulla (HP:0100957)	3.02276469
13	Progressive macrocephaly (HP:0004481)	2.98182517
14	Medial flaring of the eyebrow (HP:0010747)	2.97492865
15	Volvulus (HP:0002580)	2.88100979
16	Abnormality of the renal cortex (HP:0011035)	2.84496094
17	Renal cortical cysts (HP:0000803)	2.77928141
18	Cystic liver disease (HP:0006706)	2.75397812
19	Decreased central vision (HP:0007663)	2.73523476
20	Mitochondrial inheritance (HP:0001427)	2.71055902
21	Hemiparesis (HP:0001269)	2.65736477
22	Acute encephalopathy (HP:0006846)	2.61552146
23	Hyperventilation (HP:0002883)	2.61238376
24	Increased CSF lactate (HP:0002490)	2.60842968
25	Type II lissencephaly (HP:0007260)	2.59849606
26	Focal seizures (HP:0007359)	2.57857539
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.56719085
28	Abnormality of the labia minora (HP:0012880)	2.56041345
29	Attenuation of retinal blood vessels (HP:0007843)	2.54720392
30	Absent/shortened dynein arms (HP:0200106)	2.53106115
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.53106115
32	Abolished electroretinogram (ERG) (HP:0000550)	2.51224333
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.48767078
34	Gait imbalance (HP:0002141)	2.39673178
35	Intestinal atresia (HP:0011100)	2.39257621
36	Methylmalonic acidemia (HP:0002912)	2.38249179
37	Abnormal ciliary motility (HP:0012262)	2.38043771
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37782926
39	Increased corneal curvature (HP:0100692)	2.35018041
40	Keratoconus (HP:0000563)	2.35018041
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.34206939
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.34206939
43	Pendular nystagmus (HP:0012043)	2.34092477
44	Anencephaly (HP:0002323)	2.31674710
45	Optic disc pallor (HP:0000543)	2.28862174
46	Congenital primary aphakia (HP:0007707)	2.26936321
47	Nephrogenic diabetes insipidus (HP:0009806)	2.23465861
48	Hepatocellular necrosis (HP:0001404)	2.22487182
49	Limb dystonia (HP:0002451)	2.21340624
50	Broad-based gait (HP:0002136)	2.20325021
51	Hepatic necrosis (HP:0002605)	2.15080376
52	Hypomagnesemia (HP:0002917)	2.14281439
53	Febrile seizures (HP:0002373)	2.13257740
54	Progressive cerebellar ataxia (HP:0002073)	2.11782177
55	Increased hepatocellular lipid droplets (HP:0006565)	2.11087278
56	Dialeptic seizures (HP:0011146)	2.10682843
57	3-Methylglutaconic aciduria (HP:0003535)	2.09626627
58	Sclerocornea (HP:0000647)	2.09295903
59	Constricted visual fields (HP:0001133)	2.05943383
60	Narrow forehead (HP:0000341)	2.05202690
61	Postaxial hand polydactyly (HP:0001162)	2.04925372
62	Polydipsia (HP:0001959)	2.04371053
63	Abnormal drinking behavior (HP:0030082)	2.04371053
64	Male pseudohermaphroditism (HP:0000037)	2.02673940
65	Genital tract atresia (HP:0001827)	2.02437096
66	Lipid accumulation in hepatocytes (HP:0006561)	2.01661785
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00354968
68	Thyroid-stimulating hormone excess (HP:0002925)	1.99186160
69	Tubular atrophy (HP:0000092)	1.95632205
70	Myokymia (HP:0002411)	1.94989148
71	Inability to walk (HP:0002540)	1.94549508
72	Optic nerve hypoplasia (HP:0000609)	1.94290765
73	Absence seizures (HP:0002121)	1.94142798
74	Atonic seizures (HP:0010819)	1.93192328
75	Progressive inability to walk (HP:0002505)	1.93041924
76	Postaxial foot polydactyly (HP:0001830)	1.92393864
77	Vaginal atresia (HP:0000148)	1.91233884
78	Methylmalonic aciduria (HP:0012120)	1.90417364
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89697881
80	Ketoacidosis (HP:0001993)	1.89635192
81	Gaze-evoked nystagmus (HP:0000640)	1.88986836
82	Furrowed tongue (HP:0000221)	1.84738368
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.83537492
84	Congenital hepatic fibrosis (HP:0002612)	1.82526798
85	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82444852
86	Increased serum lactate (HP:0002151)	1.81843780
87	Lissencephaly (HP:0001339)	1.80630196
88	Drooling (HP:0002307)	1.77033286
89	Cerebral edema (HP:0002181)	1.75501226
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73796771
91	Gastrointestinal atresia (HP:0002589)	1.73046360
92	Tubulointerstitial nephritis (HP:0001970)	1.72936354
93	Generalized tonic-clonic seizures (HP:0002069)	1.72076725
94	Hyperglycinemia (HP:0002154)	1.71074074
95	Polyphagia (HP:0002591)	1.70789331
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69188730
97	Glycosuria (HP:0003076)	1.67683744
98	Abnormality of urine glucose concentration (HP:0011016)	1.67683744
99	Hypoplastic iliac wings (HP:0002866)	1.67215611
100	Polyuria (HP:0000103)	1.67147521

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.69191570
2	FRK	3.96229202
3	CASK	3.06773123
4	PNCK	2.67371298
5	MARK1	2.54092350
6	WNK3	2.50517233
7	ADRBK2	2.37308377
8	NUAK1	2.23745439
9	TNIK	2.13479310
10	PINK1	2.11704054
11	WNK4	2.11057624
12	BMPR1B	1.99502597
13	MAPK13	1.95706271
14	NTRK3	1.79165542
15	ZAK	1.69177571
16	GRK1	1.64324311
17	FGFR2	1.60430363
18	MAP3K4	1.52263529
19	PHKG1	1.51545319
20	PHKG2	1.51545319
21	TRIM28	1.50060338
22	DAPK2	1.49503401
23	TAOK3	1.47091379
24	INSRR	1.40713328
25	OXSR1	1.37040026
26	DYRK2	1.36461578
27	STK39	1.31782405
28	PLK2	1.28610860
29	PAK3	1.26734457
30	MAP3K9	1.26277545
31	VRK2	1.18295500
32	VRK1	1.13368197
33	NTRK2	1.11567221
34	EPHA4	1.06536289
35	TAF1	1.04398746
36	CDK3	1.02138061
37	NEK1	1.00350867
38	CCNB1	0.98612360
39	MKNK2	0.96805858
40	PRKCE	0.96084759
41	WEE1	0.95659269
42	CSNK1G2	0.95406143
43	MAPK15	0.94276230
44	PRKCG	0.93289784
45	PLK3	0.91576311
46	MAP2K7	0.90926463
47	ERBB3	0.88923786
48	TSSK6	0.85712187
49	TLK1	0.84099355
50	CDK19	0.83573925
51	ADRBK1	0.80002895
52	CSNK1G1	0.79592619
53	CSNK1G3	0.79000093
54	MINK1	0.74780802
55	BCKDK	0.73251502
56	PLK4	0.70242058
57	BCR	0.67248945
58	AKT3	0.66680521
59	PIK3CG	0.66074749
60	CAMK1	0.65487021
61	STK38L	0.60949475
62	UHMK1	0.59984561
63	BUB1	0.59271938
64	NEK2	0.58433034
65	PRKG1	0.57475023
66	NME1	0.55131674
67	TYRO3	0.54964141
68	IRAK1	0.54708210
69	CSNK1A1	0.53927137
70	MKNK1	0.53555535
71	RPS6KA4	0.53139525
72	PKN1	0.52522325
73	ACVR1B	0.51412676
74	OBSCN	0.51161334
75	TGFBR1	0.51147818
76	TNK2	0.50143067
77	BRSK2	0.49599440
78	MAPKAPK5	0.49280050
79	MAP3K12	0.48582061
80	CSNK1A1L	0.48062139
81	MATK	0.46356232
82	TIE1	0.45382432
83	CAMK2A	0.45221947
84	PLK1	0.43217001
85	PRKACA	0.42517858
86	PRKCQ	0.42385709
87	MUSK	0.39744822
88	DYRK1A	0.38491949
89	CSNK1E	0.38041635
90	IRAK2	0.37427496
91	DYRK3	0.36843343
92	MST4	0.36717051
93	GRK5	0.36419735
94	ATM	0.34505272
95	NLK	0.34006239
96	PRKACB	0.32078688
97	RPS6KA5	0.31666019
98	CSNK1D	0.30970268
99	CDK5	0.30616802
100	PRKCA	0.30373213

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.02416446
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.91154791
3	Protein export_Homo sapiens_hsa03060	2.91145506
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.77040287
5	Phototransduction_Homo sapiens_hsa04744	2.59035895
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41967316
7	Nicotine addiction_Homo sapiens_hsa05033	2.35768274
8	Butanoate metabolism_Homo sapiens_hsa00650	2.16541090
9	Parkinsons disease_Homo sapiens_hsa05012	2.10695529
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.02726586
11	Caffeine metabolism_Homo sapiens_hsa00232	1.91032410
12	Basal transcription factors_Homo sapiens_hsa03022	1.83649313
13	Olfactory transduction_Homo sapiens_hsa04740	1.73772810
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72547836
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72230748
16	Taste transduction_Homo sapiens_hsa04742	1.70988473
17	One carbon pool by folate_Homo sapiens_hsa00670	1.68854293
18	RNA polymerase_Homo sapiens_hsa03020	1.68770693
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.67691131
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66279047
21	Homologous recombination_Homo sapiens_hsa03440	1.66136819
22	RNA degradation_Homo sapiens_hsa03018	1.53823542
23	Asthma_Homo sapiens_hsa05310	1.53611680
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.49126976
25	Huntingtons disease_Homo sapiens_hsa05016	1.48542199
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47525427
27	GABAergic synapse_Homo sapiens_hsa04727	1.44001092
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42449652
29	Morphine addiction_Homo sapiens_hsa05032	1.41673138
30	Alzheimers disease_Homo sapiens_hsa05010	1.38718771
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38035064
32	Insulin secretion_Homo sapiens_hsa04911	1.37950678
33	Circadian entrainment_Homo sapiens_hsa04713	1.33692007
34	Propanoate metabolism_Homo sapiens_hsa00640	1.33048051
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31091756
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29054415
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26686940
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.23856370
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.18611819
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16133952
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.13117169
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.11677024
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.06026440
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02854157
45	Regulation of autophagy_Homo sapiens_hsa04140	1.01164859
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00833527
47	Proteasome_Homo sapiens_hsa03050	1.00797061
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.98780780
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98650760
50	Serotonergic synapse_Homo sapiens_hsa04726	0.97260675
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96789126
52	Salivary secretion_Homo sapiens_hsa04970	0.95952462
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95948175
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94174482
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93851158
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92168089
57	Sulfur metabolism_Homo sapiens_hsa00920	0.92119944
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90801217
59	Cocaine addiction_Homo sapiens_hsa05030	0.88947710
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85719232
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85145343
62	Amphetamine addiction_Homo sapiens_hsa05031	0.83748059
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.79204816
64	Purine metabolism_Homo sapiens_hsa00230	0.78162197
65	Allograft rejection_Homo sapiens_hsa05330	0.77258420
66	Retinol metabolism_Homo sapiens_hsa00830	0.73201835
67	Folate biosynthesis_Homo sapiens_hsa00790	0.69970678
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68699720
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67008776
70	RNA transport_Homo sapiens_hsa03013	0.66709337
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66390031
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66128708
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65731661
74	Peroxisome_Homo sapiens_hsa04146	0.65016518
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63926019
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63810112
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.63614765
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63230799
79	Fatty acid elongation_Homo sapiens_hsa00062	0.61588034
80	Ribosome_Homo sapiens_hsa03010	0.61224048
81	Metabolic pathways_Homo sapiens_hsa01100	0.58546645
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.56468378
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.55812464
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51506654
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47814569
86	Cholinergic synapse_Homo sapiens_hsa04725	0.46525175
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46318952
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46060766
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44326705
90	Renin secretion_Homo sapiens_hsa04924	0.41468247
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40850739
92	Long-term depression_Homo sapiens_hsa04730	0.39695753
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.38753967
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37206895
95	Gastric acid secretion_Homo sapiens_hsa04971	0.33884340
96	Oocyte meiosis_Homo sapiens_hsa04114	0.32939761
97	Glutathione metabolism_Homo sapiens_hsa00480	0.29702437
98	Mineral absorption_Homo sapiens_hsa04978	0.29659019
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29285240
100	Spliceosome_Homo sapiens_hsa03040	0.28501428

NPIPA8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »