NPIPB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.03796165
2acrosome reaction (GO:0007340)6.73349674
3sperm motility (GO:0030317)6.43757045
4protein targeting to Golgi (GO:0000042)5.53576264
5response to pheromone (GO:0019236)5.51254080
6establishment of protein localization to Golgi (GO:0072600)5.47657535
7single strand break repair (GO:0000012)5.20543607
8plasma membrane fusion (GO:0045026)5.14347234
9retrograde transport, vesicle recycling within Golgi (GO:0000301)5.13238651
10multicellular organism reproduction (GO:0032504)5.12114068
11sperm-egg recognition (GO:0035036)4.61789800
12spermatid development (GO:0007286)4.39008416
13protein polyglutamylation (GO:0018095)4.20983743
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20332973
15sperm capacitation (GO:0048240)4.16893640
16phosphatidylethanolamine biosynthetic process (GO:0006646)4.15121621
17reproduction (GO:0000003)4.11577147
18seminiferous tubule development (GO:0072520)4.11268375
19protein localization to Golgi apparatus (GO:0034067)4.07068550
20cell-cell recognition (GO:0009988)4.05915780
21chromosome condensation (GO:0030261)4.03372755
22piRNA metabolic process (GO:0034587)3.98817276
23DNA packaging (GO:0006323)3.97439410
24cell wall macromolecule catabolic process (GO:0016998)3.97179776
25centriole replication (GO:0007099)3.82693721
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81709812
27rRNA methylation (GO:0031167)3.76638773
28positive regulation of granulocyte differentiation (GO:0030854)3.75541058
29regulation of B cell receptor signaling pathway (GO:0050855)3.73291973
30phosphatidylethanolamine metabolic process (GO:0046337)3.67024441
31binding of sperm to zona pellucida (GO:0007339)3.66491878
32RNA destabilization (GO:0050779)3.65739516
33regulation of Rab GTPase activity (GO:0032313)3.63122630
34positive regulation of Rab GTPase activity (GO:0032851)3.63122630
35cilium or flagellum-dependent cell motility (GO:0001539)3.60918975
36cell wall macromolecule metabolic process (GO:0044036)3.60050442
37regulation of ARF GTPase activity (GO:0032312)3.39896499
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38647117
39regulation of cilium movement (GO:0003352)3.37436354
40rRNA modification (GO:0000154)3.30796877
41spermatid nucleus differentiation (GO:0007289)3.30308553
42DNA methylation involved in gamete generation (GO:0043046)3.21895748
43regulation of granulocyte differentiation (GO:0030852)3.21654559
44mast cell activation involved in immune response (GO:0002279)3.20955285
45mast cell degranulation (GO:0043303)3.20955285
46cellular ketone body metabolic process (GO:0046950)3.20727438
47spermatogenesis (GO:0007283)3.16811255
48male gamete generation (GO:0048232)3.16331725
49chromatin silencing (GO:0006342)3.09099697
50single fertilization (GO:0007338)3.06172601
51NAD biosynthetic process (GO:0009435)3.02882811
52centriole assembly (GO:0098534)3.02692791
53calcium ion-dependent exocytosis (GO:0017156)3.00508858
54ketone body metabolic process (GO:1902224)2.97753385
55mast cell activation (GO:0045576)2.96193140
56male meiosis I (GO:0007141)2.95985709
57positive regulation of gamma-delta T cell activation (GO:0046645)2.95855579
58gamete generation (GO:0007276)2.93695484
59regulation of acrosome reaction (GO:0060046)2.91218480
60regulation of gamma-delta T cell differentiation (GO:0045586)2.89685749
61regulation of female gonad development (GO:2000194)2.88798241
62negative regulation of inclusion body assembly (GO:0090084)2.87795013
63microtubule severing (GO:0051013)2.87265409
64microtubule depolymerization (GO:0007019)2.81852333
65fertilization (GO:0009566)2.78829594
66B cell receptor signaling pathway (GO:0050853)2.77345637
67negative regulation of cAMP-mediated signaling (GO:0043951)2.75603678
68positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.73355138
69positive regulation of B cell differentiation (GO:0045579)2.72354092
70DNA deamination (GO:0045006)2.72134080
71negative regulation of granulocyte differentiation (GO:0030853)2.70036497
72regulation of gamma-delta T cell activation (GO:0046643)2.69893325
73germ cell development (GO:0007281)2.65409361
74L-fucose catabolic process (GO:0042355)2.65109116
75fucose catabolic process (GO:0019317)2.65109116
76L-fucose metabolic process (GO:0042354)2.65109116
77microtubule nucleation (GO:0007020)2.64845648
78glycerol ether metabolic process (GO:0006662)2.61367759
79regulation of meiosis I (GO:0060631)2.60591278
80indolalkylamine metabolic process (GO:0006586)2.59538183
81negative regulation of histone methylation (GO:0031061)2.59115930
82positive regulation of T-helper cell differentiation (GO:0045624)2.58191045
83immunoglobulin mediated immune response (GO:0016064)2.58028609
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.57816378
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53366813
86poly(A)+ mRNA export from nucleus (GO:0016973)2.52639373
87regulation of B cell differentiation (GO:0045577)2.52392083
88positive regulation of antigen processing and presentation (GO:0002579)2.47009058
89opioid receptor signaling pathway (GO:0038003)2.46802991
90regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.46541647
91regulation of T-helper cell differentiation (GO:0045622)2.44847511
92organic cation transport (GO:0015695)2.44840383
93axonemal dynein complex assembly (GO:0070286)2.44042405
94defense response to protozoan (GO:0042832)2.43611863
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.43449981
96actin nucleation (GO:0045010)2.42400247
97histone mRNA catabolic process (GO:0071044)2.41326843
98detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.40966716
99microtubule polymerization or depolymerization (GO:0031109)2.39580988
100nicotinamide nucleotide biosynthetic process (GO:0019359)2.38858370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.73416764
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90456633
3SCL_19346495_ChIP-Seq_HPC-7_Human2.58089200
4RUNX_20019798_ChIP-Seq_JUKART_Human2.56726348
5ZNF274_21170338_ChIP-Seq_K562_Hela2.54503642
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47884316
7MYB_26560356_Chip-Seq_TH2_Human2.08728946
8DROSHA_22980978_ChIP-Seq_HELA_Human2.01211468
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.92650411
10BP1_19119308_ChIP-ChIP_Hs578T_Human1.90119046
11IRF8_21731497_ChIP-ChIP_J774_Mouse1.88768782
12VDR_22108803_ChIP-Seq_LS180_Human1.87596019
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85054412
14ER_23166858_ChIP-Seq_MCF-7_Human1.83637622
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81116534
16IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.80893075
17CBP_20019798_ChIP-Seq_JUKART_Human1.80893075
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74051649
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71895314
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71895314
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70825058
22RAC3_21632823_ChIP-Seq_H3396_Human1.70249816
23BCL6_27268052_Chip-Seq_Bcells_Human1.69364265
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68047084
25GATA3_27048872_Chip-Seq_THYMUS_Human1.67526405
26GATA3_26560356_Chip-Seq_TH2_Human1.63338575
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62177469
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61795270
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60134777
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59786223
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.56747142
32ERA_21632823_ChIP-Seq_H3396_Human1.55200822
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54916846
34VDR_24787735_ChIP-Seq_THP-1_Human1.52651265
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51997556
36CIITA_25753668_ChIP-Seq_RAJI_Human1.49896836
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.48297314
38NANOG_20526341_ChIP-Seq_ESCs_Human1.47798713
39SMRT_27268052_Chip-Seq_Bcells_Human1.47600272
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.47494547
41MYB_26560356_Chip-Seq_TH1_Human1.44498893
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44051226
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42589464
44SPI1_23127762_ChIP-Seq_K562_Human1.42221268
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.41673555
46MYC_19829295_ChIP-Seq_ESCs_Human1.41492562
47E2F1_20622854_ChIP-Seq_HELA_Human1.41188723
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40422785
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.37700822
50CEBPB_22108803_ChIP-Seq_LS180_Human1.37406938
51P300_27268052_Chip-Seq_Bcells_Human1.35120965
52TAF2_19829295_ChIP-Seq_ESCs_Human1.32951283
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32263570
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32249339
55BCOR_27268052_Chip-Seq_Bcells_Human1.30478753
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.29554558
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28702281
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28397348
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27641229
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26465558
61OCT4_20526341_ChIP-Seq_ESCs_Human1.26090965
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25496979
63GATA3_26560356_Chip-Seq_TH1_Human1.24912296
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24485802
65TP53_22573176_ChIP-Seq_HFKS_Human1.18057565
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17697093
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15992417
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15401424
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14339907
70HOXB7_26014856_ChIP-Seq_BT474_Human1.13275859
71MAF_26560356_Chip-Seq_TH2_Human1.12792115
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12491648
73P53_21459846_ChIP-Seq_SAOS-2_Human1.12273152
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.10796193
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10690960
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09908352
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09906953
78PHF8_20622854_ChIP-Seq_HELA_Human1.07937031
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07567586
80STAT1_20625510_ChIP-Seq_HELA_Human1.07454103
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07121205
82BCAT_22108803_ChIP-Seq_LS180_Human1.05608083
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.05528803
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04581753
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.04581753
86TCF4_23295773_ChIP-Seq_U87_Human1.04284584
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.04123925
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04092967
89UTX_26944678_Chip-Seq_JUKART_Human1.04008538
90P68_20966046_ChIP-Seq_HELA_Human1.03894604
91SOX2_19829295_ChIP-Seq_ESCs_Human1.03481655
92NANOG_19829295_ChIP-Seq_ESCs_Human1.03481655
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03345939
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03317151
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02046901
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97857111
97OCT4_19829295_ChIP-Seq_ESCs_Human0.96439229
98SMC4_20622854_ChIP-Seq_HELA_Human0.96157033
99ETV1_20927104_ChIP-Seq_GIST48_Human0.96100613
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94874633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.61027212
2MP0005377_hearing/vestibular/ear_phenot3.09777464
3MP0003878_abnormal_ear_physiology3.09777464
4MP0001835_abnormal_antigen_presentation2.84899870
5MP0002138_abnormal_hepatobiliary_system2.62616187
6MP0005670_abnormal_white_adipose2.41343796
7MP0002132_abnormal_respiratory_system2.29107923
8MP0003698_abnormal_male_reproductive2.21999362
9MP0003763_abnormal_thymus_physiology2.19793175
10MP0001348_abnormal_lacrimal_gland2.17411900
11MP0008877_abnormal_DNA_methylation2.15695784
12MP0001929_abnormal_gametogenesis2.04156121
13MP0001800_abnormal_humoral_immune2.03161649
14MP0003646_muscle_fatigue1.98195739
15MP0000678_abnormal_parathyroid_gland1.91138223
16MP0005310_abnormal_salivary_gland1.85270851
17MP0005000_abnormal_immune_tolerance1.77538020
18MP0003436_decreased_susceptibility_to1.72041928
19MP0005075_abnormal_melanosome_morpholog1.71104865
20MP0003172_abnormal_lysosome_physiology1.70322612
21MP0002723_abnormal_immune_serum1.68889966
22MP0000372_irregular_coat_pigmentation1.68677526
23MP0001545_abnormal_hematopoietic_system1.65903593
24MP0005397_hematopoietic_system_phenotyp1.65903593
25MP0002102_abnormal_ear_morphology1.64194036
26MP0001790_abnormal_immune_system1.63405961
27MP0005387_immune_system_phenotype1.63405961
28MP0002420_abnormal_adaptive_immunity1.60387904
29MP0002398_abnormal_bone_marrow1.55268921
30MP0000015_abnormal_ear_pigmentation1.55023727
31MP0001501_abnormal_sleep_pattern1.54685993
32MP0005671_abnormal_response_to1.54633077
33MP0002653_abnormal_ependyma_morphology1.54628526
34MP0001819_abnormal_immune_cell1.54289362
35MP0005551_abnormal_eye_electrophysiolog1.52625449
36MP0002452_abnormal_antigen_presenting1.50275509
37MP0001986_abnormal_taste_sensitivity1.46074325
38MP0003787_abnormal_imprinting1.44892864
39MP0003183_abnormal_peptide_metabolism1.42055578
40MP0000716_abnormal_immune_system1.33473263
41MP0000703_abnormal_thymus_morphology1.32444505
42MP0002419_abnormal_innate_immunity1.30375293
43MP0000689_abnormal_spleen_morphology1.30189831
44MP0003718_maternal_effect1.29879433
45MP0009278_abnormal_bone_marrow1.29464945
46MP0005025_abnormal_response_to1.25384217
47MP0002148_abnormal_hypersensitivity_rea1.23207745
48MP0009333_abnormal_splenocyte_physiolog1.23072433
49MP0003943_abnormal_hepatobiliary_system1.22436083
50MP0004742_abnormal_vestibular_system1.18740766
51MP0009785_altered_susceptibility_to1.18718929
52MP0002722_abnormal_immune_system1.17811670
53MP0002396_abnormal_hematopoietic_system1.17578750
54MP0005379_endocrine/exocrine_gland_phen1.15484648
55MP0001764_abnormal_homeostasis1.15307303
56MP0000685_abnormal_immune_system1.14659182
57MP0003195_calcinosis1.13958843
58MP0002429_abnormal_blood_cell1.13783133
59MP0001968_abnormal_touch/_nociception1.13771618
60MP0002928_abnormal_bile_duct1.13556260
61MP0002254_reproductive_system_inflammat1.12991927
62MP0005646_abnormal_pituitary_gland1.11382249
63MP0005360_urolithiasis1.09605990
64MP0001873_stomach_inflammation1.05626300
65MP0009764_decreased_sensitivity_to1.04024713
66MP0003724_increased_susceptibility_to1.03559581
67MP0002210_abnormal_sex_determination1.02205094
68MP0002161_abnormal_fertility/fecundity0.99997694
69MP0004808_abnormal_hematopoietic_stem0.99964307
70MP0008058_abnormal_DNA_repair0.96993769
71MP0008872_abnormal_physiological_respon0.95702741
72MP0010155_abnormal_intestine_physiology0.95550119
73MP0001486_abnormal_startle_reflex0.93833679
74MP0005167_abnormal_blood-brain_barrier0.91942612
75MP0005464_abnormal_platelet_physiology0.91713232
76MP0004147_increased_porphyrin_level0.91711097
77MP0008469_abnormal_protein_level0.87865441
78MP0000681_abnormal_thyroid_gland0.86147810
79MP0000653_abnormal_sex_gland0.85712574
80MP0003045_fibrosis0.85083785
81MP0001145_abnormal_male_reproductive0.84076644
82MP0002249_abnormal_larynx_morphology0.82958395
83MP0002822_catalepsy0.82308702
84MP0002405_respiratory_system_inflammati0.82295866
85MP0008995_early_reproductive_senescence0.80920981
86MP0005535_abnormal_body_temperature0.79597376
87MP0002127_abnormal_cardiovascular_syste0.79563955
88MP0002876_abnormal_thyroid_physiology0.78807183
89MP0005395_other_phenotype0.78778223
90MP0001270_distended_abdomen0.78371161
91MP0000465_gastrointestinal_hemorrhage0.76495164
92MP0001485_abnormal_pinna_reflex0.76459295
93MP0002229_neurodegeneration0.76175864
94MP0001845_abnormal_inflammatory_respons0.75898806
95MP0003806_abnormal_nucleotide_metabolis0.75299946
96MP0000371_diluted_coat_color0.75156264
97MP0001765_abnormal_ion_homeostasis0.74009497
98MP0010094_abnormal_chromosome_stability0.73848897
99MP0004043_abnormal_pH_regulation0.73833659
100MP0005084_abnormal_gallbladder_morpholo0.72886878

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.09997486
2Attenuation of retinal blood vessels (HP:0007843)4.50556510
3Abnormal rod and cone electroretinograms (HP:0008323)3.83739216
4Panhypogammaglobulinemia (HP:0003139)3.78670538
5Agammaglobulinemia (HP:0004432)3.32181618
6Bony spicule pigmentary retinopathy (HP:0007737)3.11343158
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.11163885
8Absent/shortened dynein arms (HP:0200106)3.11163885
9Abnormal delayed hypersensitivity skin test (HP:0002963)2.99331839
10Elevated erythrocyte sedimentation rate (HP:0003565)2.84896304
11Recurrent cutaneous fungal infections (HP:0011370)2.83957723
12Chronic mucocutaneous candidiasis (HP:0002728)2.83957723
13Tubulointerstitial nephritis (HP:0001970)2.83114524
14Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75274165
15Volvulus (HP:0002580)2.73228722
16Decreased central vision (HP:0007663)2.68330247
17Abnormality of the aortic arch (HP:0012303)2.65440382
18Recurrent fungal infections (HP:0002841)2.65278521
19Hypoplastic ischia (HP:0003175)2.62570485
20Impulsivity (HP:0100710)2.59687616
21Cone-rod dystrophy (HP:0000548)2.58086097
22Chronic hepatic failure (HP:0100626)2.57104851
23Enlarged epiphyses (HP:0010580)2.56084955
24Abnormality of B cell number (HP:0010975)2.55092565
25Tetany (HP:0001281)2.50175570
26Hypochromic microcytic anemia (HP:0004840)2.44225646
27Nephronophthisis (HP:0000090)2.43667361
28Severe combined immunodeficiency (HP:0004430)2.40960760
29Congenital stationary night blindness (HP:0007642)2.40162586
30Stomatitis (HP:0010280)2.39470472
31Abnormality of macular pigmentation (HP:0008002)2.34156754
32Hypoplasia of the thymus (HP:0000778)2.29729462
33Abnormality of the renal medulla (HP:0100957)2.29519813
34Metaphyseal dysplasia (HP:0100255)2.29205334
35Gastrointestinal inflammation (HP:0004386)2.29009445
36Myositis (HP:0100614)2.27984859
37Encephalitis (HP:0002383)2.27584699
38Meningitis (HP:0001287)2.23816529
39Abnormality of the parathyroid morphology (HP:0011766)2.22696131
40Prolonged bleeding time (HP:0003010)2.22389690
41Pustule (HP:0200039)2.18910688
42Molar tooth sign on MRI (HP:0002419)2.18890726
43Abnormality of midbrain morphology (HP:0002418)2.18890726
44Inflammation of the large intestine (HP:0002037)2.17227087
45Recurrent skin infections (HP:0001581)2.16108017
46Gaze-evoked nystagmus (HP:0000640)2.12118824
47True hermaphroditism (HP:0010459)2.11105844
48B lymphocytopenia (HP:0010976)2.09811267
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.07768373
50Abnormality of the ischium (HP:0003174)2.06468039
51Polydipsia (HP:0001959)2.06155961
52Abnormal drinking behavior (HP:0030082)2.06155961
53Cystic liver disease (HP:0006706)2.05053785
54Hyperkalemia (HP:0002153)2.04631167
55Thyroiditis (HP:0100646)2.02082404
56Colitis (HP:0002583)2.01053689
57Intestinal atresia (HP:0011100)1.99319254
58Abnormality of dental color (HP:0011073)1.99031301
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99005150
60Abnormality of T cell physiology (HP:0011840)1.98848175
61Abnormality of the prostate (HP:0008775)1.98669285
62Stomach cancer (HP:0012126)1.97393387
63Pigmentary retinal degeneration (HP:0001146)1.96924173
64Long clavicles (HP:0000890)1.96005126
65Abnormality of lateral ventricle (HP:0030047)1.94046588
66Abnormality of the renal cortex (HP:0011035)1.93370975
67Abnormal ciliary motility (HP:0012262)1.93330407
68Pancreatic cysts (HP:0001737)1.92025909
69Autoimmune hemolytic anemia (HP:0001890)1.92020636
70Polyuria (HP:0000103)1.91764130
71Pancreatic islet-cell hyperplasia (HP:0004510)1.91447775
72Abnormal respiratory motile cilium morphology (HP:0005938)1.90951644
73Abnormal respiratory epithelium morphology (HP:0012253)1.90951644
74Macular degeneration (HP:0000608)1.90577538
75Tubular atrophy (HP:0000092)1.89934289
76Retrobulbar optic neuritis (HP:0100654)1.89443705
77Optic neuritis (HP:0100653)1.89443705
78Clubbing of toes (HP:0100760)1.89051985
79Mesangial abnormality (HP:0001966)1.87112106
80Aplasia/Hypoplasia of the thymus (HP:0010515)1.86421565
81Abnormal urine output (HP:0012590)1.85851523
82Pancreatic fibrosis (HP:0100732)1.85405825
83Recurrent bacterial skin infections (HP:0005406)1.85006455
84Leukocytosis (HP:0001974)1.84165095
85Granulocytopenia (HP:0001913)1.83512326
86Abnormality of T cells (HP:0002843)1.81369372
87Bulbous nose (HP:0000414)1.81151429
88Sloping forehead (HP:0000340)1.80447242
89Asymmetric septal hypertrophy (HP:0001670)1.79684876
90Keratoconjunctivitis (HP:0001096)1.79578810
91Hypochromic anemia (HP:0001931)1.79057975
92Type II lissencephaly (HP:0007260)1.78666067
93Photophobia (HP:0000613)1.78239652
94Vasculitis (HP:0002633)1.78059276
95Abnormality of DNA repair (HP:0003254)1.77417566
96Recurrent abscess formation (HP:0002722)1.76381539
97Congenital sensorineural hearing impairment (HP:0008527)1.76010376
98IgG deficiency (HP:0004315)1.75995928
99Abnormality of the peritoneum (HP:0002585)1.75534410
100Orchitis (HP:0100796)1.75134321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.46625347
2PLK43.26511335
3BRD43.19201320
4MAP4K13.09675680
5TXK2.98887294
6MAP4K22.82540006
7TAOK32.73614900
8BMPR1B2.53170896
9INSRR2.50704621
10ACVR1B2.41151446
11KIT2.20091878
12TNK22.15263267
13CDK122.02067645
14WNK42.01028198
15NUAK11.99020664
16TEC1.77594567
17RIPK41.74414295
18ADRBK21.68954822
19SYK1.59558075
20JAK31.56878761
21FES1.47900744
22TYK21.47855597
23BCKDK1.46745096
24ERN11.36683339
25CSF1R1.30726127
26MAP2K61.28587375
27WNK11.28175239
28ITK1.26698922
29PTK2B1.22915572
30PLK21.20377387
31MST1R1.17963423
32SIK21.15530552
33IKBKE1.14736453
34PIK3CG1.10399064
35BLK1.08409148
36PDK11.05882902
37PNCK1.05751788
38PINK11.01766615
39LYN0.98270601
40IKBKB0.97812427
41OXSR10.97280947
42DDR20.97124401
43FLT30.95142516
44STK390.93962370
45MARK30.91532807
46NEK20.91474925
47IRAK40.89180476
48MAP2K30.88789150
49BTK0.88366389
50MATK0.88282329
51LATS10.87996319
52CAMK1G0.87514560
53CDK70.87113532
54PRKCQ0.86964459
55MAP2K20.84428481
56LCK0.83503925
57GRK60.82943892
58ZAP700.81346617
59TNIK0.80992173
60MAPK150.80469710
61PRKAA20.80454294
62PRKCH0.76413574
63MAP3K70.73753066
64CDK30.70738432
65HCK0.70349532
66TGFBR10.70349006
67STK380.66354406
68WNK30.65131549
69PDPK10.61404874
70CDK90.59039406
71GRK10.56557846
72TBK10.56537114
73TESK10.54081012
74NLK0.53773824
75PDK20.53318117
76KDR0.53119425
77MAPK130.51082619
78CDK40.50495688
79MAP3K140.50058502
80BMPR20.49807593
81MAPK10.48315803
82MAPK110.47706680
83CDK190.47251106
84ATR0.47148127
85IRAK10.45210724
86SIK30.43879872
87HIPK20.42939763
88VRK20.40235528
89CAMK10.39379472
90RPS6KA60.36692203
91CAMK40.35328373
92PRKD30.35020942
93RPS6KC10.33507646
94RPS6KL10.33507646
95CDK20.33032425
96GSK3B0.31454189
97MAPK30.31249839
98SGK10.30715736
99MST40.30594272
100EIF2AK30.30373083

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.51804083
2Primary immunodeficiency_Homo sapiens_hsa053403.38572528
3Graft-versus-host disease_Homo sapiens_hsa053323.36001080
4Autoimmune thyroid disease_Homo sapiens_hsa053203.27917722
5Type I diabetes mellitus_Homo sapiens_hsa049402.84802349
6Asthma_Homo sapiens_hsa053102.75177016
7Antigen processing and presentation_Homo sapiens_hsa046122.72926423
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.68897767
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36374646
10Olfactory transduction_Homo sapiens_hsa047402.26395806
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25681772
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87872191
13Staphylococcus aureus infection_Homo sapiens_hsa051501.85166741
14Fanconi anemia pathway_Homo sapiens_hsa034601.83300208
15Leishmaniasis_Homo sapiens_hsa051401.77139658
16Homologous recombination_Homo sapiens_hsa034401.70591915
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58050815
18ABC transporters_Homo sapiens_hsa020101.57099473
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.55653553
20Hematopoietic cell lineage_Homo sapiens_hsa046401.54220089
21Herpes simplex infection_Homo sapiens_hsa051681.50539186
22Phototransduction_Homo sapiens_hsa047441.49371604
23Taste transduction_Homo sapiens_hsa047421.38590760
24B cell receptor signaling pathway_Homo sapiens_hsa046621.36229514
25Butanoate metabolism_Homo sapiens_hsa006501.31256467
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30932703
27Dorso-ventral axis formation_Homo sapiens_hsa043201.28402161
28Viral myocarditis_Homo sapiens_hsa054161.27556051
29Linoleic acid metabolism_Homo sapiens_hsa005911.25169846
30Influenza A_Homo sapiens_hsa051641.25132197
31Non-homologous end-joining_Homo sapiens_hsa034501.19755209
32T cell receptor signaling pathway_Homo sapiens_hsa046601.17151389
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14283516
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.13500348
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12711131
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07012241
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.05136000
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.05121580
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02347363
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02117411
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01764550
42Other glycan degradation_Homo sapiens_hsa005111.00857667
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00443270
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00377766
45RNA transport_Homo sapiens_hsa030130.99059896
46Measles_Homo sapiens_hsa051620.95624105
47Basal transcription factors_Homo sapiens_hsa030220.92953044
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.92668130
49Tuberculosis_Homo sapiens_hsa051520.88307230
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85039700
51mRNA surveillance pathway_Homo sapiens_hsa030150.81158731
52Osteoclast differentiation_Homo sapiens_hsa043800.79751176
53Base excision repair_Homo sapiens_hsa034100.75857769
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74611413
55Legionellosis_Homo sapiens_hsa051340.74319001
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70528955
57Retinol metabolism_Homo sapiens_hsa008300.68400354
58Tryptophan metabolism_Homo sapiens_hsa003800.68148477
59RNA degradation_Homo sapiens_hsa030180.67155584
60Nitrogen metabolism_Homo sapiens_hsa009100.65910209
61Ether lipid metabolism_Homo sapiens_hsa005650.64478296
62African trypanosomiasis_Homo sapiens_hsa051430.63691795
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.63549165
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.62643210
65Toxoplasmosis_Homo sapiens_hsa051450.62619865
66Peroxisome_Homo sapiens_hsa041460.62386244
67Fatty acid biosynthesis_Homo sapiens_hsa000610.61899573
68Salivary secretion_Homo sapiens_hsa049700.61888690
69Lysine degradation_Homo sapiens_hsa003100.61456322
70Oocyte meiosis_Homo sapiens_hsa041140.61217767
71Platelet activation_Homo sapiens_hsa046110.59967005
72Glycerolipid metabolism_Homo sapiens_hsa005610.59773407
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59129221
74RNA polymerase_Homo sapiens_hsa030200.58039346
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57900215
76Epstein-Barr virus infection_Homo sapiens_hsa051690.56833710
77Fatty acid degradation_Homo sapiens_hsa000710.55038618
78Arachidonic acid metabolism_Homo sapiens_hsa005900.54317024
79Calcium signaling pathway_Homo sapiens_hsa040200.51782081
80Inositol phosphate metabolism_Homo sapiens_hsa005620.50023526
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49824204
82Notch signaling pathway_Homo sapiens_hsa043300.49442204
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48993804
84Rheumatoid arthritis_Homo sapiens_hsa053230.48806236
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47259436
86Purine metabolism_Homo sapiens_hsa002300.45555748
87Acute myeloid leukemia_Homo sapiens_hsa052210.44520242
88Complement and coagulation cascades_Homo sapiens_hsa046100.42945855
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39159194
90Regulation of autophagy_Homo sapiens_hsa041400.38925281
91Chemical carcinogenesis_Homo sapiens_hsa052040.38108355
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37668791
93Selenocompound metabolism_Homo sapiens_hsa004500.37249202
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31438719
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30374298
96Malaria_Homo sapiens_hsa051440.26903192
97Arginine and proline metabolism_Homo sapiens_hsa003300.26265354
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24989275
99MAPK signaling pathway_Homo sapiens_hsa040100.23127775
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23116895

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »