NPIPB15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.25017692
2acrosome reaction (GO:0007340)8.60463571
3response to pheromone (GO:0019236)7.65729491
4fusion of sperm to egg plasma membrane (GO:0007342)7.51732331
5single strand break repair (GO:0000012)7.21595691
6protein targeting to Golgi (GO:0000042)7.11831249
7establishment of protein localization to Golgi (GO:0072600)6.86367918
8retrograde transport, vesicle recycling within Golgi (GO:0000301)6.62071831
9protein polyglutamylation (GO:0018095)6.43862538
10sperm capacitation (GO:0048240)6.39469408
11multicellular organism reproduction (GO:0032504)6.31751815
12spermatid development (GO:0007286)6.28752332
13regulation of cilium movement (GO:0003352)5.92768150
14axonemal dynein complex assembly (GO:0070286)5.75545135
15plasma membrane fusion (GO:0045026)5.64346654
16rRNA methylation (GO:0031167)5.56288706
17protein localization to Golgi apparatus (GO:0034067)5.52472478
18sperm-egg recognition (GO:0035036)5.49696858
19reproduction (GO:0000003)5.49623428
20phosphatidylethanolamine biosynthetic process (GO:0006646)5.34933729
21cellular ketone body metabolic process (GO:0046950)5.27077494
22microtubule severing (GO:0051013)5.20366166
23chromosome condensation (GO:0030261)5.16829722
24DNA packaging (GO:0006323)5.04315099
25spermatid nucleus differentiation (GO:0007289)5.02735569
26phosphatidylethanolamine metabolic process (GO:0046337)4.98722393
27cilium or flagellum-dependent cell motility (GO:0001539)4.92774402
28epithelial cilium movement (GO:0003351)4.91085922
29calcium ion-dependent exocytosis (GO:0017156)4.82930362
30cell-cell recognition (GO:0009988)4.71675528
31ketone body metabolic process (GO:1902224)4.70928927
32rRNA modification (GO:0000154)4.62419855
33spermatogenesis (GO:0007283)4.53558267
34RNA destabilization (GO:0050779)4.52886845
35male gamete generation (GO:0048232)4.51658564
36motile cilium assembly (GO:0044458)4.43482330
37binding of sperm to zona pellucida (GO:0007339)4.38110243
38centriole replication (GO:0007099)4.31956489
39single fertilization (GO:0007338)4.25708331
40cilium movement (GO:0003341)4.21558379
41microtubule depolymerization (GO:0007019)4.19859004
42organic cation transport (GO:0015695)4.13014348
43gamete generation (GO:0007276)4.12917292
44axoneme assembly (GO:0035082)4.10192026
45sexual reproduction (GO:0019953)4.06925227
46regulation of microtubule-based movement (GO:0060632)4.03101409
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95228295
48microtubule polymerization or depolymerization (GO:0031109)3.93525843
49piRNA metabolic process (GO:0034587)3.90094517
50regulation of Rab GTPase activity (GO:0032313)3.86916990
51positive regulation of Rab GTPase activity (GO:0032851)3.86916990
52centriole assembly (GO:0098534)3.84777401
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69078116
54behavioral response to nicotine (GO:0035095)3.68971315
55cell wall macromolecule metabolic process (GO:0044036)3.64815382
56germ cell development (GO:0007281)3.54903934
57negative regulation of inclusion body assembly (GO:0090084)3.47297668
58seminiferous tubule development (GO:0072520)3.46327870
59cell wall macromolecule catabolic process (GO:0016998)3.44084311
60fertilization (GO:0009566)3.40996360
61regulation of transcription involved in cell fate commitment (GO:0060850)3.37568829
62coenzyme catabolic process (GO:0009109)3.30192708
63multicellular organismal reproductive process (GO:0048609)3.26782337
64NAD biosynthetic process (GO:0009435)3.26721799
65male meiosis I (GO:0007141)3.20014026
66cellular process involved in reproduction in multicellular organism (GO:0022412)3.18318345
67left/right axis specification (GO:0070986)3.16427990
68nephron epithelium morphogenesis (GO:0072088)3.13698877
69nephron tubule morphogenesis (GO:0072078)3.13698877
70intra-Golgi vesicle-mediated transport (GO:0006891)3.08214392
71male meiosis (GO:0007140)3.02963005
72detection of light stimulus involved in visual perception (GO:0050908)2.96887330
73detection of light stimulus involved in sensory perception (GO:0050962)2.96887330
74DNA methylation involved in gamete generation (GO:0043046)2.92449047
75regulation of centriole replication (GO:0046599)2.85956821
76cilium organization (GO:0044782)2.80170863
77cilium assembly (GO:0042384)2.77796763
78indole-containing compound catabolic process (GO:0042436)2.75224654
79indolalkylamine catabolic process (GO:0046218)2.75224654
80tryptophan catabolic process (GO:0006569)2.75224654
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73604217
82amine catabolic process (GO:0009310)2.68801952
83cellular biogenic amine catabolic process (GO:0042402)2.68801952
84positive regulation of guanylate cyclase activity (GO:0031284)2.68296955
85somite rostral/caudal axis specification (GO:0032525)2.67626614
86nonmotile primary cilium assembly (GO:0035058)2.64496127
87regulation of guanylate cyclase activity (GO:0031282)2.61876262
88brain morphogenesis (GO:0048854)2.61114501
89photoreceptor cell maintenance (GO:0045494)2.58534947
90intraciliary transport (GO:0042073)2.55302947
91peptidyl-glutamic acid modification (GO:0018200)2.53595772
92regulation of hexokinase activity (GO:1903299)2.52116787
93regulation of glucokinase activity (GO:0033131)2.52116787
94ventricular system development (GO:0021591)2.51617499
95nicotinamide nucleotide biosynthetic process (GO:0019359)2.50708450
96pyridine nucleotide biosynthetic process (GO:0019363)2.50708450
97spinal cord motor neuron differentiation (GO:0021522)2.50431430
98protein localization to cilium (GO:0061512)2.49293447
99chromatin silencing (GO:0006342)2.48791895
100meiosis I (GO:0007127)2.48044532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65877461
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22337621
3ZNF274_21170338_ChIP-Seq_K562_Hela2.57777060
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24541356
5IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20165615
6CBP_20019798_ChIP-Seq_JUKART_Human2.20165615
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13956416
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11530489
9EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06829282
10EZH2_22144423_ChIP-Seq_EOC_Human2.06663385
11FUS_26573619_Chip-Seq_HEK293_Human2.01551685
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94401983
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94401983
14VDR_22108803_ChIP-Seq_LS180_Human1.88559089
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86780542
16ER_23166858_ChIP-Seq_MCF-7_Human1.86650654
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.86313682
18ERA_21632823_ChIP-Seq_H3396_Human1.83411535
19ETV2_25802403_ChIP-Seq_MESCs_Mouse1.82098849
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81064938
21NANOG_20526341_ChIP-Seq_ESCs_Human1.75529099
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74944477
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64328254
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60990395
25MYC_19829295_ChIP-Seq_ESCs_Human1.60293306
26EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.55332765
27GATA3_21878914_ChIP-Seq_MCF-7_Human1.55308854
28AR_25329375_ChIP-Seq_VCAP_Human1.55091536
29TAF2_19829295_ChIP-Seq_ESCs_Human1.53340350
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52770934
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51138154
32P300_19829295_ChIP-Seq_ESCs_Human1.50293189
33RAC3_21632823_ChIP-Seq_H3396_Human1.49015210
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47594820
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.44382433
36DROSHA_22980978_ChIP-Seq_HELA_Human1.43606817
37RBPJ_21746931_ChIP-Seq_IB4_Human1.40552165
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40489008
39BCL6_27268052_Chip-Seq_Bcells_Human1.39425306
40OCT4_20526341_ChIP-Seq_ESCs_Human1.39056888
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38243575
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.37536992
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37154396
44NCOR_22424771_ChIP-Seq_293T_Human1.36748711
45GBX2_23144817_ChIP-Seq_PC3_Human1.35880311
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35351676
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34460480
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.34181589
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33471222
50ETV1_20927104_ChIP-Seq_GIST48_Human1.33194741
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32922455
52CTCF_20526341_ChIP-Seq_ESCs_Human1.31159329
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.29597327
54E2F1_20622854_ChIP-Seq_HELA_Human1.29100413
55HOXB7_26014856_ChIP-Seq_BT474_Human1.28090503
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.27201616
57NANOG_19829295_ChIP-Seq_ESCs_Human1.26633340
58SOX2_19829295_ChIP-Seq_ESCs_Human1.26633340
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25129570
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.25129570
61PHF8_20622853_ChIP-Seq_HELA_Human1.24559089
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.23865098
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23766113
64NFYB_21822215_ChIP-Seq_K562_Human1.23466646
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22813723
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22272020
67RUNX2_22187159_ChIP-Seq_PCA_Human1.20753310
68CTCF_27219007_Chip-Seq_Bcells_Human1.20407185
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19212413
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.18562208
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.18050588
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16902871
73P53_21459846_ChIP-Seq_SAOS-2_Human1.16812770
74TBL1_22424771_ChIP-Seq_293T_Human1.16290186
75NFYA_21822215_ChIP-Seq_K562_Human1.16216361
76PHF8_20622854_ChIP-Seq_HELA_Human1.16044139
77P300_27268052_Chip-Seq_Bcells_Human1.16007933
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.15432004
79SMRT_27268052_Chip-Seq_Bcells_Human1.14840105
80GATA6_21074721_ChIP-Seq_CACO-2_Human1.14090936
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13742433
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12557913
83TCF4_22108803_ChIP-Seq_LS180_Human1.11666681
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11250064
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.11033043
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.10228262
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09536898
88BCAT_22108803_ChIP-Seq_LS180_Human1.09299681
89CEBPB_22108803_ChIP-Seq_LS180_Human1.08718272
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08081757
91REST_21632747_ChIP-Seq_MESCs_Mouse1.07569548
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07442807
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.06998374
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05477535
95SMAD4_21799915_ChIP-Seq_A2780_Human1.05145645
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02636386
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.02585491
98TP53_22573176_ChIP-Seq_HFKS_Human1.02488330
99ERG_20517297_ChIP-Seq_VCAP_Human1.02369054
100BCOR_27268052_Chip-Seq_Bcells_Human1.01911828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.56181588
2MP0005377_hearing/vestibular/ear_phenot3.58785753
3MP0003878_abnormal_ear_physiology3.58785753
4MP0005670_abnormal_white_adipose3.09340662
5MP0003698_abnormal_male_reproductive2.90753670
6MP0002138_abnormal_hepatobiliary_system2.88032772
7MP0005379_endocrine/exocrine_gland_phen2.57357785
8MP0001929_abnormal_gametogenesis2.54531423
9MP0003646_muscle_fatigue2.33802375
10MP0003011_delayed_dark_adaptation2.21169318
11MP0003195_calcinosis2.09017845
12MP0006292_abnormal_olfactory_placode2.02197210
13MP0005551_abnormal_eye_electrophysiolog1.97322516
14MP0001485_abnormal_pinna_reflex1.91754738
15MP0002837_dystrophic_cardiac_calcinosis1.85737199
16MP0003787_abnormal_imprinting1.61977347
17MP0002163_abnormal_gland_morphology1.60385379
18MP0005646_abnormal_pituitary_gland1.49750245
19MP0002822_catalepsy1.48624139
20MP0008877_abnormal_DNA_methylation1.47669821
21MP0002161_abnormal_fertility/fecundity1.47130027
22MP0001486_abnormal_startle_reflex1.42844900
23MP0002132_abnormal_respiratory_system1.41207449
24MP0001968_abnormal_touch/_nociception1.40966137
25MP0002653_abnormal_ependyma_morphology1.37080600
26MP0004043_abnormal_pH_regulation1.36331191
27MP0001501_abnormal_sleep_pattern1.34597940
28MP0001348_abnormal_lacrimal_gland1.30926891
29MP0001666_abnormal_nutrient_absorption1.30915321
30MP0005084_abnormal_gallbladder_morpholo1.30628557
31MP0002210_abnormal_sex_determination1.30574618
32MP0005645_abnormal_hypothalamus_physiol1.29111662
33MP0008004_abnormal_stomach_pH1.28864062
34MP0004742_abnormal_vestibular_system1.26389741
35MP0002139_abnormal_hepatobiliary_system1.24338751
36MP0002928_abnormal_bile_duct1.24201023
37MP0003718_maternal_effect1.23623775
38MP0001984_abnormal_olfaction1.21341384
39MP0005365_abnormal_bile_salt1.19469056
40MP0001986_abnormal_taste_sensitivity1.15854874
41MP0008875_abnormal_xenobiotic_pharmacok1.15188236
42MP0002876_abnormal_thyroid_physiology1.14400411
43MP0005253_abnormal_eye_physiology1.13988113
44MP0005310_abnormal_salivary_gland1.13848552
45MP0001765_abnormal_ion_homeostasis1.11644734
46MP0002638_abnormal_pupillary_reflex1.11209436
47MP0002277_abnormal_respiratory_mucosa1.11142944
48MP0002282_abnormal_trachea_morphology1.09141287
49MP0001963_abnormal_hearing_physiology1.08601300
50MP0010386_abnormal_urinary_bladder1.08488276
51MP0003172_abnormal_lysosome_physiology1.08197414
52MP0002102_abnormal_ear_morphology1.07616841
53MP0000653_abnormal_sex_gland1.06858535
54MP0004885_abnormal_endolymph1.05952110
55MP0001145_abnormal_male_reproductive1.05599241
56MP0000026_abnormal_inner_ear1.05356799
57MP0005408_hypopigmentation1.04366987
58MP0002229_neurodegeneration1.03463563
59MP0010329_abnormal_lipoprotein_level1.00347237
60MP0004142_abnormal_muscle_tone0.99834368
61MP0005332_abnormal_amino_acid0.98887386
62MP0002557_abnormal_social/conspecific_i0.98656302
63MP0009745_abnormal_behavioral_response0.98259901
64MP0002735_abnormal_chemical_nociception0.98120409
65MP0003183_abnormal_peptide_metabolism0.96798709
66MP0002127_abnormal_cardiovascular_syste0.96739688
67MP0002272_abnormal_nervous_system0.96011699
68MP0000516_abnormal_urinary_system0.94535511
69MP0005367_renal/urinary_system_phenotyp0.94535511
70MP0009764_decreased_sensitivity_to0.93191562
71MP0002693_abnormal_pancreas_physiology0.92751833
72MP0002733_abnormal_thermal_nociception0.91531112
73MP0003252_abnormal_bile_duct0.91426011
74MP0003879_abnormal_hair_cell0.90867187
75MP0001970_abnormal_pain_threshold0.90710763
76MP0008789_abnormal_olfactory_epithelium0.90652606
77MP0000678_abnormal_parathyroid_gland0.90007874
78MP0001905_abnormal_dopamine_level0.86722526
79MP0008995_early_reproductive_senescence0.86368083
80MP0005636_abnormal_mineral_homeostasis0.83106987
81MP0008872_abnormal_physiological_respon0.82895068
82MP0002160_abnormal_reproductive_system0.82618368
83MP0002234_abnormal_pharynx_morphology0.81605034
84MP0005535_abnormal_body_temperature0.80573657
85MP0005174_abnormal_tail_pigmentation0.78269629
86MP0002249_abnormal_larynx_morphology0.78052166
87MP0002067_abnormal_sensory_capabilities0.75011654
88MP0005085_abnormal_gallbladder_physiolo0.74961278
89MP0003136_yellow_coat_color0.74260759
90MP0005394_taste/olfaction_phenotype0.73303496
91MP0005499_abnormal_olfactory_system0.73303496
92MP0001944_abnormal_pancreas_morphology0.71002749
93MP0002572_abnormal_emotion/affect_behav0.70996341
94MP0003121_genomic_imprinting0.70660432
95MP0000230_abnormal_systemic_arterial0.70455269
96MP0004133_heterotaxia0.70271046
97MP0005448_abnormal_energy_balance0.70173810
98MP0000427_abnormal_hair_cycle0.69869958
99MP0004085_abnormal_heartbeat0.68368569
100MP0006072_abnormal_retinal_apoptosis0.68271100

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.76506702
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.30602445
3Absent/shortened dynein arms (HP:0200106)5.30602445
4Tubulointerstitial nephritis (HP:0001970)4.48977672
5Abnormal rod and cone electroretinograms (HP:0008323)4.39506431
6Abnormal respiratory epithelium morphology (HP:0012253)3.98152529
7Abnormal respiratory motile cilium morphology (HP:0005938)3.98152529
8Abnormal ciliary motility (HP:0012262)3.91557383
9Bony spicule pigmentary retinopathy (HP:0007737)3.90883534
10Abnormal respiratory motile cilium physiology (HP:0012261)3.87826926
11Nephronophthisis (HP:0000090)3.77053875
12Attenuation of retinal blood vessels (HP:0007843)3.71155569
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.59895044
14Chronic hepatic failure (HP:0100626)3.59602637
15Abnormality of the renal medulla (HP:0100957)3.42874248
16Pancreatic cysts (HP:0001737)3.22229799
17Abnormal drinking behavior (HP:0030082)3.21908710
18Polydipsia (HP:0001959)3.21908710
19Pancreatic fibrosis (HP:0100732)3.14265368
20Abnormal urine output (HP:0012590)3.13701230
21Tubular atrophy (HP:0000092)3.03607967
22Polyuria (HP:0000103)3.02314187
23Abnormality of renal excretion (HP:0011036)2.97564547
24Facial shape deformation (HP:0011334)2.95810630
25Potter facies (HP:0002009)2.95810630
26Abnormality of macular pigmentation (HP:0008002)2.84558757
27Abnormality of midbrain morphology (HP:0002418)2.80875844
28Molar tooth sign on MRI (HP:0002419)2.80875844
29Congenital stationary night blindness (HP:0007642)2.78687067
30True hermaphroditism (HP:0010459)2.76904778
31Hyperkalemia (HP:0002153)2.74765582
32Tubulointerstitial abnormality (HP:0001969)2.71877312
33Stage 5 chronic kidney disease (HP:0003774)2.65242989
34Cystic liver disease (HP:0006706)2.62998090
35Infertility (HP:0000789)2.61557000
36Abnormality of the renal cortex (HP:0011035)2.61399246
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56793842
38Type II lissencephaly (HP:0007260)2.53516406
39Abnormality of urine glucose concentration (HP:0011016)2.50370969
40Glycosuria (HP:0003076)2.50370969
41Decreased central vision (HP:0007663)2.48297138
42Abnormality of dental color (HP:0011073)2.43549602
43Chronic bronchitis (HP:0004469)2.42614102
44Nasal polyposis (HP:0100582)2.42097601
45Pendular nystagmus (HP:0012043)2.40580989
46Medial flaring of the eyebrow (HP:0010747)2.40250841
47Progressive cerebellar ataxia (HP:0002073)2.37202127
48Occipital encephalocele (HP:0002085)2.36688031
49Rhinitis (HP:0012384)2.34292883
50Congenital sensorineural hearing impairment (HP:0008527)2.33012997
51Azoospermia (HP:0000027)2.32550104
52Asymmetric septal hypertrophy (HP:0001670)2.28585442
53Cone-rod dystrophy (HP:0000548)2.16612954
54Generalized aminoaciduria (HP:0002909)2.16517561
55Male infertility (HP:0003251)2.16069936
56Impulsivity (HP:0100710)2.12087384
57Amelogenesis imperfecta (HP:0000705)2.09270828
58Abnormality of potassium homeostasis (HP:0011042)2.08853271
59Abnormal spermatogenesis (HP:0008669)2.05479365
60Bronchiectasis (HP:0002110)2.05438259
61Anencephaly (HP:0002323)2.05214730
62Tetany (HP:0001281)2.01800293
63Metabolic alkalosis (HP:0200114)2.01108631
64Gait imbalance (HP:0002141)2.00245052
65Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98583626
66Enlarged epiphyses (HP:0010580)1.97796993
67Abnormality of chloride homeostasis (HP:0011422)1.97251295
68Optic nerve hypoplasia (HP:0000609)1.96983832
69Congenital primary aphakia (HP:0007707)1.94118613
70Hypoplastic ischia (HP:0003175)1.93807674
71Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92635588
72Hypophosphatemic rickets (HP:0004912)1.87712659
73Congenital hepatic fibrosis (HP:0002612)1.86858468
74Abolished electroretinogram (ERG) (HP:0000550)1.85815771
75Sclerocornea (HP:0000647)1.84936726
76Renal Fanconi syndrome (HP:0001994)1.84043965
77Renal dysplasia (HP:0000110)1.82809488
78Bell-shaped thorax (HP:0001591)1.82506979
79Congenital malformation of the right heart (HP:0011723)1.82250599
80Double outlet right ventricle (HP:0001719)1.82250599
81Decreased circulating renin level (HP:0003351)1.81885916
82Delayed CNS myelination (HP:0002188)1.80495236
83Abnormality of the nasal mucosa (HP:0000433)1.80427219
84Abnormality of renal resorption (HP:0011038)1.78506672
85Postaxial foot polydactyly (HP:0001830)1.77079772
86Abnormality of the aortic arch (HP:0012303)1.76314866
87Bulbous nose (HP:0000414)1.75867929
88Nephrogenic diabetes insipidus (HP:0009806)1.75464128
89Epiphyseal dysplasia (HP:0002656)1.73843458
90Type 2 muscle fiber atrophy (HP:0003554)1.72568366
91Hypokalemia (HP:0002900)1.72408390
92Hypoalbuminemia (HP:0003073)1.72360971
93Abnormal albumin level (HP:0012116)1.72360971
94Myokymia (HP:0002411)1.71331791
95Macular degeneration (HP:0000608)1.70523948
96Metaphyseal dysplasia (HP:0100255)1.70212949
97Cerebellar dysplasia (HP:0007033)1.69073296
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67939255
99Tubulointerstitial fibrosis (HP:0005576)1.67638273
100Photophobia (HP:0000613)1.67509806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.45004843
2INSRR3.56507595
3FRK3.23653016
4MAP4K23.07150049
5BMPR1B2.74726498
6DDR22.56977578
7TESK12.48320117
8PNCK2.35602629
9PLK22.23824291
10ADRBK22.22773030
11WNK42.12031120
12ACVR1B2.08227011
13GRK11.97921127
14MAPK151.95532424
15PRKD31.85463942
16STK381.76899632
17NUAK11.64695698
18PINK11.57619433
19BRD41.56987052
20MUSK1.53335696
21STK38L1.50336644
22CAMK1G1.49157763
23MST1R1.40697674
24PTK2B1.21226617
25TXK1.18322601
26OXSR11.16091360
27IKBKB1.15728771
28WNK31.12222888
29SIK21.07154336
30FGFR21.05692768
31CDK191.05142096
32WNK11.03502278
33AKT31.02256637
34STK390.99012433
35TIE10.97817945
36PDK20.93039541
37TNK20.92478685
38MAP3K40.91415200
39BRAF0.88075964
40PDK10.87346689
41PRKCG0.84091867
42CDK30.82149862
43MAPK130.81536440
44ZAK0.80507080
45STK160.77433594
46NTRK30.75892666
47MAPKAPK30.73338702
48MAP2K60.73242989
49TAOK30.70749008
50ARAF0.70258207
51MAP2K20.70125241
52CAMK10.69679199
53PRKAA20.69110480
54PDPK10.68832768
55MARK30.67706987
56MAP2K70.67389958
57TYRO30.66894338
58TLK10.63664362
59MKNK20.63389146
60PRKCQ0.63213850
61KIT0.61758186
62MAP3K90.60887891
63CAMK1D0.60606692
64ITK0.59104045
65PAK30.58527053
66CHUK0.58490421
67PRKG20.58190774
68PRKCE0.57947225
69PRKG10.57369342
70LATS10.54398291
71PRKCI0.54353430
72TEC0.54244950
73DMPK0.54201139
74NLK0.50251209
75MAP3K130.47939364
76CAMKK20.47545037
77PIK3CG0.46272161
78PRKACA0.44886796
79PRKCZ0.43437911
80TNIK0.43423256
81NEK60.42929673
82ADRBK10.41895295
83GRK70.41391625
84UHMK10.40913625
85PIK3CA0.40800208
86FER0.40650142
87ERBB30.40584976
88NTRK20.40372106
89PRKCH0.38087678
90IKBKE0.36435235
91GRK60.33720860
92RPS6KA10.33505355
93NME10.30888168
94DYRK1B0.29544671
95DAPK20.29402772
96PRKCA0.29158138
97PRKAA10.28828860
98MAPK10.28498076
99TGFBR10.27211926
100SGK10.27093045

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.94968043
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.57096136
3Butanoate metabolism_Homo sapiens_hsa006502.40622590
4Type I diabetes mellitus_Homo sapiens_hsa049402.27940619
5Linoleic acid metabolism_Homo sapiens_hsa005912.26153451
6Fatty acid biosynthesis_Homo sapiens_hsa000612.21022333
7Olfactory transduction_Homo sapiens_hsa047402.13836752
8Phototransduction_Homo sapiens_hsa047442.12724442
9Allograft rejection_Homo sapiens_hsa053302.08596599
10Oxidative phosphorylation_Homo sapiens_hsa001902.02073753
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96907855
12Autoimmune thyroid disease_Homo sapiens_hsa053201.94135919
13Nitrogen metabolism_Homo sapiens_hsa009101.81405528
14Graft-versus-host disease_Homo sapiens_hsa053321.79065110
15Retinol metabolism_Homo sapiens_hsa008301.72128904
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59984915
17Chemical carcinogenesis_Homo sapiens_hsa052041.58635094
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.54104036
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52457825
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52001871
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48419192
22Protein export_Homo sapiens_hsa030601.45832533
23Fat digestion and absorption_Homo sapiens_hsa049751.45511057
24Asthma_Homo sapiens_hsa053101.39959393
25Fatty acid degradation_Homo sapiens_hsa000711.37241368
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34580210
27Peroxisome_Homo sapiens_hsa041461.33500325
28Cardiac muscle contraction_Homo sapiens_hsa042601.32422261
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.31960440
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31223506
31Huntingtons disease_Homo sapiens_hsa050161.30155340
32Caffeine metabolism_Homo sapiens_hsa002321.29431033
33Taste transduction_Homo sapiens_hsa047421.28577036
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28525346
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23220498
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.22947901
37Dorso-ventral axis formation_Homo sapiens_hsa043201.22348233
38Parkinsons disease_Homo sapiens_hsa050121.21236142
39Basal transcription factors_Homo sapiens_hsa030221.18879237
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14768713
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14353459
42Glycerolipid metabolism_Homo sapiens_hsa005611.13366718
43Tryptophan metabolism_Homo sapiens_hsa003801.11611068
44Antigen processing and presentation_Homo sapiens_hsa046121.04482587
45Insulin secretion_Homo sapiens_hsa049111.03495766
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.01585704
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98519890
48Regulation of autophagy_Homo sapiens_hsa041400.97909048
49Ether lipid metabolism_Homo sapiens_hsa005650.95479165
50ABC transporters_Homo sapiens_hsa020100.94597143
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93087896
52Ribosome_Homo sapiens_hsa030100.92708515
53Phenylalanine metabolism_Homo sapiens_hsa003600.90076390
54Collecting duct acid secretion_Homo sapiens_hsa049660.88905042
55Arachidonic acid metabolism_Homo sapiens_hsa005900.85251848
56Fanconi anemia pathway_Homo sapiens_hsa034600.84973532
57Tyrosine metabolism_Homo sapiens_hsa003500.84567786
58Selenocompound metabolism_Homo sapiens_hsa004500.83464166
59Arginine and proline metabolism_Homo sapiens_hsa003300.80660478
60Arginine biosynthesis_Homo sapiens_hsa002200.72869321
61RNA degradation_Homo sapiens_hsa030180.71879253
62Staphylococcus aureus infection_Homo sapiens_hsa051500.68824095
63Alzheimers disease_Homo sapiens_hsa050100.68809979
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68456545
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67391269
66Morphine addiction_Homo sapiens_hsa050320.67143266
67Salivary secretion_Homo sapiens_hsa049700.66959130
68Histidine metabolism_Homo sapiens_hsa003400.66049286
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64743554
70Serotonergic synapse_Homo sapiens_hsa047260.61287299
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.60114351
72Metabolic pathways_Homo sapiens_hsa011000.59107972
73Complement and coagulation cascades_Homo sapiens_hsa046100.58977904
74Propanoate metabolism_Homo sapiens_hsa006400.58051434
75Nicotine addiction_Homo sapiens_hsa050330.57749068
76Type II diabetes mellitus_Homo sapiens_hsa049300.57306735
77Pancreatic secretion_Homo sapiens_hsa049720.56933945
78Rheumatoid arthritis_Homo sapiens_hsa053230.54064764
79Fatty acid metabolism_Homo sapiens_hsa012120.53083111
80RNA transport_Homo sapiens_hsa030130.52505451
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52226592
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51811335
83Sulfur relay system_Homo sapiens_hsa041220.50524091
84Folate biosynthesis_Homo sapiens_hsa007900.46707946
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46345756
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.46307326
87Mineral absorption_Homo sapiens_hsa049780.46210759
88PPAR signaling pathway_Homo sapiens_hsa033200.46112531
89Protein digestion and absorption_Homo sapiens_hsa049740.45101015
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44890280
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44692247
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44332187
93Purine metabolism_Homo sapiens_hsa002300.43192360
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.43125462
95Glutamatergic synapse_Homo sapiens_hsa047240.40688016
96cAMP signaling pathway_Homo sapiens_hsa040240.38774605
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37757915
98Calcium signaling pathway_Homo sapiens_hsa040200.37129269
99Circadian entrainment_Homo sapiens_hsa047130.37015337
100Ovarian steroidogenesis_Homo sapiens_hsa049130.35167541

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