NPIPB1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.88717834
2fusion of sperm to egg plasma membrane (GO:0007342)9.80247496
3response to pheromone (GO:0019236)7.83233865
4plasma membrane fusion (GO:0045026)7.46027821
5spermatid development (GO:0007286)7.09412853
6microtubule depolymerization (GO:0007019)6.89588023
7multicellular organism reproduction (GO:0032504)6.81883627
8rRNA methylation (GO:0031167)6.79686851
9cellular ketone body metabolic process (GO:0046950)6.70390099
10single strand break repair (GO:0000012)6.54773893
11sperm capacitation (GO:0048240)6.52048801
12sperm-egg recognition (GO:0035036)6.44763753
13chromosome condensation (GO:0030261)6.36681266
14spermatid nucleus differentiation (GO:0007289)6.36240131
15ketone body metabolic process (GO:1902224)6.09954720
16DNA packaging (GO:0006323)6.03611160
17reproduction (GO:0000003)5.99095854
18protein polyglutamylation (GO:0018095)5.93953044
19axonemal dynein complex assembly (GO:0070286)5.85417692
20protein targeting to Golgi (GO:0000042)5.78907782
21rRNA modification (GO:0000154)5.77740349
22microtubule polymerization or depolymerization (GO:0031109)5.73247936
23calcium ion-dependent exocytosis (GO:0017156)5.62485388
24binding of sperm to zona pellucida (GO:0007339)5.56837802
25establishment of protein localization to Golgi (GO:0072600)5.52121562
26retrograde transport, vesicle recycling within Golgi (GO:0000301)5.39218849
27cilium or flagellum-dependent cell motility (GO:0001539)5.37701094
28cell-cell recognition (GO:0009988)5.35765799
29spermatogenesis (GO:0007283)5.34011617
30male gamete generation (GO:0048232)5.32184871
31centriole replication (GO:0007099)5.00294931
32epithelial cilium movement (GO:0003351)4.98627428
33gamete generation (GO:0007276)4.86634272
34motile cilium assembly (GO:0044458)4.84839885
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78369078
36sexual reproduction (GO:0019953)4.60145349
37single fertilization (GO:0007338)4.52318156
38regulation of cilium movement (GO:0003352)4.46389406
39phosphatidylethanolamine biosynthetic process (GO:0006646)4.43845660
40organic cation transport (GO:0015695)4.35529619
41centriole assembly (GO:0098534)4.29288860
42phosphatidylethanolamine metabolic process (GO:0046337)4.25712998
43gonadal mesoderm development (GO:0007506)4.18651857
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.17126726
45negative regulation of inclusion body assembly (GO:0090084)4.15417789
46seminiferous tubule development (GO:0072520)4.11280144
47cilium movement (GO:0003341)4.04170655
48protein localization to Golgi apparatus (GO:0034067)4.03376321
49positive regulation of Rab GTPase activity (GO:0032851)3.92417177
50regulation of Rab GTPase activity (GO:0032313)3.92417177
51microtubule nucleation (GO:0007020)3.87131447
52multicellular organismal reproductive process (GO:0048609)3.84303369
53cell wall macromolecule catabolic process (GO:0016998)3.79180676
54germ cell development (GO:0007281)3.75740685
55regulation of transcription involved in cell fate commitment (GO:0060850)3.69919258
56cell wall macromolecule metabolic process (GO:0044036)3.68126269
57fertilization (GO:0009566)3.66341717
58regulation of centriole replication (GO:0046599)3.64856593
59male meiosis I (GO:0007141)3.64189948
60male meiosis (GO:0007140)3.63471985
61one-carbon compound transport (GO:0019755)3.62047389
62coenzyme catabolic process (GO:0009109)3.61187096
63cellular process involved in reproduction in multicellular organism (GO:0022412)3.54529763
64microtubule severing (GO:0051013)3.52330425
65polyamine biosynthetic process (GO:0006596)3.44800629
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38811656
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38811656
68RNA destabilization (GO:0050779)3.38701165
69detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.27505845
70left/right axis specification (GO:0070986)3.13193614
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11895622
72piRNA metabolic process (GO:0034587)3.10757912
73axoneme assembly (GO:0035082)3.03482270
74meiosis I (GO:0007127)3.01484523
75homocysteine metabolic process (GO:0050667)3.00598197
76positive regulation of guanylate cyclase activity (GO:0031284)2.99508754
77negative regulation of granulocyte differentiation (GO:0030853)2.98304335
78positive regulation of endothelial cell differentiation (GO:0045603)2.95389758
79acrosome assembly (GO:0001675)2.93007268
80negative regulation of Rho protein signal transduction (GO:0035024)2.86462680
81histone exchange (GO:0043486)2.85537212
82negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.84366472
83glycerol ether metabolic process (GO:0006662)2.80175310
84regulation of guanylate cyclase activity (GO:0031282)2.77798790
85cerebral cortex neuron differentiation (GO:0021895)2.74771246
86DNA methylation involved in gamete generation (GO:0043046)2.73314273
87NAD biosynthetic process (GO:0009435)2.73155962
88regulation of microtubule-based movement (GO:0060632)2.67848724
89regulation of T cell mediated cytotoxicity (GO:0001914)2.65791366
90ether metabolic process (GO:0018904)2.64763083
91regulation of phosphoprotein phosphatase activity (GO:0043666)2.62641461
92cell differentiation involved in metanephros development (GO:0072202)2.61590519
93chromatin silencing (GO:0006342)2.60749575
94regulation of inclusion body assembly (GO:0090083)2.60511302
95nucleus organization (GO:0006997)2.59218236
96mast cell degranulation (GO:0043303)2.57226692
97mast cell activation involved in immune response (GO:0002279)2.57226692
98multicellular organismal development (GO:0007275)2.55370646
99polyamine metabolic process (GO:0006595)2.55310578
100sperm motility (GO:0030317)10.0051531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56171090
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01709128
3CTBP1_25329375_ChIP-Seq_LNCAP_Human2.65732248
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.51016683
5FUS_26573619_Chip-Seq_HEK293_Human2.50862435
6EZH2_22144423_ChIP-Seq_EOC_Human2.42295092
7VDR_22108803_ChIP-Seq_LS180_Human2.33747904
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.26712435
9CBP_20019798_ChIP-Seq_JUKART_Human2.26712435
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26591143
11ZNF274_21170338_ChIP-Seq_K562_Hela2.12463600
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04893452
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.04893452
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.01966656
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01641801
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97366343
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96504442
18TAF15_26573619_Chip-Seq_HEK293_Human1.79676616
19P300_19829295_ChIP-Seq_ESCs_Human1.72999689
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71316905
21NANOG_20526341_ChIP-Seq_ESCs_Human1.69884471
22AUTS2_25519132_ChIP-Seq_293T-REX_Human1.69720644
23ERA_21632823_ChIP-Seq_H3396_Human1.68289435
24ER_23166858_ChIP-Seq_MCF-7_Human1.66696786
25MYC_19829295_ChIP-Seq_ESCs_Human1.62412578
26VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61014754
27TAF2_19829295_ChIP-Seq_ESCs_Human1.59421988
28RAC3_21632823_ChIP-Seq_H3396_Human1.58293431
29ETV2_25802403_ChIP-Seq_MESCs_Mouse1.57558639
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57164250
31PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.54116601
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53385804
33GBX2_23144817_ChIP-Seq_PC3_Human1.53189318
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.52826279
35EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.52752832
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52317277
37ERG_20517297_ChIP-Seq_VCAP_Human1.51363049
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.51146427
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51071829
40OCT4_20526341_ChIP-Seq_ESCs_Human1.50730674
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.48799303
42AR_25329375_ChIP-Seq_VCAP_Human1.46750685
43IGF1R_20145208_ChIP-Seq_DFB_Human1.46369622
44NANOG_19829295_ChIP-Seq_ESCs_Human1.45972289
45SOX2_19829295_ChIP-Seq_ESCs_Human1.45972289
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45127440
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44789421
48ETV1_20927104_ChIP-Seq_GIST48_Human1.44378076
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43899569
50RBPJ_21746931_ChIP-Seq_IB4_Human1.43438683
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43390216
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.42346056
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41920181
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.41006351
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.38812517
56E2F1_20622854_ChIP-Seq_HELA_Human1.38664117
57CBX2_22325352_ChIP-Seq_293T-Rex_Human1.38211968
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38051650
59P300_27268052_Chip-Seq_Bcells_Human1.37182604
60HOXB7_26014856_ChIP-Seq_BT474_Human1.33513968
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.32762917
62CEBPB_22108803_ChIP-Seq_LS180_Human1.32505372
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.31614540
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.31523789
65OCT1_27270436_Chip-Seq_PROSTATE_Human1.31390423
66NFYB_21822215_ChIP-Seq_K562_Human1.30060043
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.29844593
68NCOR_22424771_ChIP-Seq_293T_Human1.29517833
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29015020
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.29015020
71CTCF_20526341_ChIP-Seq_ESCs_Human1.28673650
72DROSHA_22980978_ChIP-Seq_HELA_Human1.28217491
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27996578
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.27956515
75PHF8_20622853_ChIP-Seq_HELA_Human1.27687427
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26874133
77BCL6_27268052_Chip-Seq_Bcells_Human1.26757848
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.25334143
79FOXH1_21741376_ChIP-Seq_ESCs_Human1.22199671
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.21666623
81RUNX2_22187159_ChIP-Seq_PCA_Human1.20976123
82AR_21572438_ChIP-Seq_LNCaP_Human1.18945657
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18112074
84CTCF_27219007_Chip-Seq_Bcells_Human1.17923751
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17357975
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17138244
87TBL1_22424771_ChIP-Seq_293T_Human1.17092926
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16850565
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.16387012
90STAT1_20625510_ChIP-Seq_HELA_Human1.16166038
91SMAD4_21799915_ChIP-Seq_A2780_Human1.15427981
92STAT3_23295773_ChIP-Seq_U87_Human1.15411314
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15138286
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.14139629
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13744539
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12395016
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.11731979
98NFYA_21822215_ChIP-Seq_K562_Human1.11169868
99TCF4_22108803_ChIP-Seq_LS180_Human1.09412796
100SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06777048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.13227315
2MP0005670_abnormal_white_adipose3.79336450
3MP0003878_abnormal_ear_physiology3.47173146
4MP0005377_hearing/vestibular/ear_phenot3.47173146
5MP0003698_abnormal_male_reproductive3.31328496
6MP0008995_early_reproductive_senescence2.93369294
7MP0001929_abnormal_gametogenesis2.90737411
8MP0002234_abnormal_pharynx_morphology2.67149650
9MP0000678_abnormal_parathyroid_gland2.15722868
10MP0003011_delayed_dark_adaptation2.09383783
11MP0006292_abnormal_olfactory_placode1.94943364
12MP0008877_abnormal_DNA_methylation1.92426890
13MP0000372_irregular_coat_pigmentation1.90618515
14MP0005551_abnormal_eye_electrophysiolog1.86646176
15MP0003646_muscle_fatigue1.85033861
16MP0002161_abnormal_fertility/fecundity1.71994078
17MP0005646_abnormal_pituitary_gland1.68168770
18MP0005645_abnormal_hypothalamus_physiol1.65402427
19MP0005253_abnormal_eye_physiology1.63989790
20MP0001485_abnormal_pinna_reflex1.63895413
21MP0001764_abnormal_homeostasis1.63655629
22MP0003183_abnormal_peptide_metabolism1.63178252
23MP0003136_yellow_coat_color1.61367905
24MP0005367_renal/urinary_system_phenotyp1.52502694
25MP0000516_abnormal_urinary_system1.52502694
26MP0003718_maternal_effect1.51607027
27MP0002210_abnormal_sex_determination1.43370461
28MP0000026_abnormal_inner_ear1.39726695
29MP0001963_abnormal_hearing_physiology1.37711499
30MP0009379_abnormal_foot_pigmentation1.37163988
31MP0005379_endocrine/exocrine_gland_phen1.36502569
32MP0001486_abnormal_startle_reflex1.33566784
33MP0004885_abnormal_endolymph1.29523909
34MP0002249_abnormal_larynx_morphology1.29208633
35MP0000049_abnormal_middle_ear1.27848859
36MP0001968_abnormal_touch/_nociception1.27153428
37MP0002282_abnormal_trachea_morphology1.25518087
38MP0001145_abnormal_male_reproductive1.25092194
39MP0002735_abnormal_chemical_nociception1.25047351
40MP0003252_abnormal_bile_duct1.22101994
41MP0002638_abnormal_pupillary_reflex1.19732629
42MP0000653_abnormal_sex_gland1.19604008
43MP0004142_abnormal_muscle_tone1.17558979
44MP0001348_abnormal_lacrimal_gland1.17110565
45MP0001501_abnormal_sleep_pattern1.12743220
46MP0008789_abnormal_olfactory_epithelium1.07539461
47MP0002736_abnormal_nociception_after1.06913520
48MP0000566_synostosis1.04788694
49MP0001188_hyperpigmentation1.03744058
50MP0002837_dystrophic_cardiac_calcinosis1.03541350
51MP0002822_catalepsy1.02400930
52MP0004742_abnormal_vestibular_system1.02279464
53MP0000013_abnormal_adipose_tissue1.01839040
54MP0002229_neurodegeneration1.01427457
55MP0002132_abnormal_respiratory_system0.98460830
56MP0003879_abnormal_hair_cell0.96489394
57MP0009764_decreased_sensitivity_to0.95144622
58MP0009697_abnormal_copulation0.94943002
59MP0005394_taste/olfaction_phenotype0.93814075
60MP0005499_abnormal_olfactory_system0.93814075
61MP0005075_abnormal_melanosome_morpholog0.93726987
62MP0001986_abnormal_taste_sensitivity0.93184247
63MP0002095_abnormal_skin_pigmentation0.92942870
64MP0000681_abnormal_thyroid_gland0.91376552
65MP0006276_abnormal_autonomic_nervous0.90616171
66MP0001905_abnormal_dopamine_level0.88558465
67MP0002102_abnormal_ear_morphology0.87868243
68MP0001765_abnormal_ion_homeostasis0.86540131
69MP0002138_abnormal_hepatobiliary_system0.84591928
70MP0002272_abnormal_nervous_system0.83161656
71MP0005332_abnormal_amino_acid0.82737811
72MP0006072_abnormal_retinal_apoptosis0.82254812
73MP0000003_abnormal_adipose_tissue0.81708279
74MP0000534_abnormal_ureter_morphology0.79726149
75MP0003724_increased_susceptibility_to0.79692749
76MP0002160_abnormal_reproductive_system0.77982635
77MP0002127_abnormal_cardiovascular_syste0.77121927
78MP0009046_muscle_twitch0.74597316
79MP0001661_extended_life_span0.73988714
80MP0009115_abnormal_fat_cell0.73640988
81MP0005671_abnormal_response_to0.73430978
82MP0009745_abnormal_behavioral_response0.73425369
83MP0005535_abnormal_body_temperature0.72825934
84MP0010386_abnormal_urinary_bladder0.71873775
85MP0005423_abnormal_somatic_nervous0.71753984
86MP0004133_heterotaxia0.71262538
87MP0005360_urolithiasis0.70963324
88MP0001984_abnormal_olfaction0.70763099
89MP0002938_white_spotting0.69682656
90MP0000230_abnormal_systemic_arterial0.68603256
91MP0000371_diluted_coat_color0.67275403
92MP0002733_abnormal_thermal_nociception0.66870240
93MP0008872_abnormal_physiological_respon0.66690705
94MP0002653_abnormal_ependyma_morphology0.63315300
95MP0000470_abnormal_stomach_morphology0.61572073
96MP0002067_abnormal_sensory_capabilities0.58720782
97MP0005395_other_phenotype0.58616587
98MP0002557_abnormal_social/conspecific_i0.56715285
99MP0002009_preneoplasia0.56045784
100MP0005636_abnormal_mineral_homeostasis0.54682061

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.82667011
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.56615541
3Absent/shortened dynein arms (HP:0200106)5.56615541
4Hyperalaninemia (HP:0003348)5.14798747
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.14798747
6Abnormality of alanine metabolism (HP:0010916)5.14798747
7Attenuation of retinal blood vessels (HP:0007843)4.98223312
8Tubulointerstitial nephritis (HP:0001970)4.50415131
9Abnormal respiratory epithelium morphology (HP:0012253)4.45704136
10Abnormal respiratory motile cilium morphology (HP:0005938)4.45704136
11Abnormal rod and cone electroretinograms (HP:0008323)4.16864315
12Abnormal ciliary motility (HP:0012262)4.14284278
13Bony spicule pigmentary retinopathy (HP:0007737)4.02655518
14Abnormal respiratory motile cilium physiology (HP:0012261)3.84746504
15Congenital sensorineural hearing impairment (HP:0008527)3.81555070
16Abnormality of macular pigmentation (HP:0008002)3.80145190
17Chronic hepatic failure (HP:0100626)3.65436009
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.58212727
19Cone-rod dystrophy (HP:0000548)3.53201065
20Infertility (HP:0000789)3.46788132
21Male infertility (HP:0003251)3.40914152
22Asymmetric septal hypertrophy (HP:0001670)3.19219060
23Nephronophthisis (HP:0000090)3.16979266
24Nasal polyposis (HP:0100582)3.14165634
25Generalized aminoaciduria (HP:0002909)3.06408086
26Decreased central vision (HP:0007663)2.99981222
27Polydipsia (HP:0001959)2.89319288
28Abnormal drinking behavior (HP:0030082)2.89319288
29Abnormal spermatogenesis (HP:0008669)2.82715905
30Atonic seizures (HP:0010819)2.72721111
31Amelogenesis imperfecta (HP:0000705)2.69254342
32Hyperkalemia (HP:0002153)2.58873723
33Azoospermia (HP:0000027)2.58291580
34Potter facies (HP:0002009)2.58211512
35Facial shape deformation (HP:0011334)2.58211512
36Pendular nystagmus (HP:0012043)2.52790908
37Hypoplastic ischia (HP:0003175)2.52401866
38Abnormal urine output (HP:0012590)2.47888548
39Abnormality of the renal medulla (HP:0100957)2.44586070
40Abnormality of the nasal mucosa (HP:0000433)2.41824222
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40985951
42Resting tremor (HP:0002322)2.39810602
43Pigmentary retinal degeneration (HP:0001146)2.38573147
44Stage 5 chronic kidney disease (HP:0003774)2.38034733
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.36704153
46Rhinitis (HP:0012384)2.36353018
47Abnormality of DNA repair (HP:0003254)2.35902172
48Elevated erythrocyte sedimentation rate (HP:0003565)2.35381084
49Pancreatic fibrosis (HP:0100732)2.35350709
50Epiphyseal dysplasia (HP:0002656)2.31178436
51Abnormality of midbrain morphology (HP:0002418)2.30836570
52Molar tooth sign on MRI (HP:0002419)2.30836570
53Pancreatic cysts (HP:0001737)2.28274477
54Congenital stationary night blindness (HP:0007642)2.24077644
55True hermaphroditism (HP:0010459)2.23666453
56Polyuria (HP:0000103)2.23496102
57Hypoplasia of the thymus (HP:0000778)2.20648010
58Tubulointerstitial abnormality (HP:0001969)2.19822856
59Tetany (HP:0001281)2.17796893
60Sclerocornea (HP:0000647)2.15325393
61Abnormality of renal excretion (HP:0011036)2.15235960
62Chorioretinal atrophy (HP:0000533)2.14423286
63Chronic sinusitis (HP:0011109)2.14115112
64Abnormality of dental color (HP:0011073)2.13051476
65Enlarged epiphyses (HP:0010580)2.12577771
66Insulin-resistant diabetes mellitus (HP:0000831)2.08367340
67Photophobia (HP:0000613)2.06140263
68Abnormality of the ischium (HP:0003174)2.03922416
69Ketoacidosis (HP:0001993)2.02778649
70Progressive cerebellar ataxia (HP:0002073)2.02522070
71Tubular atrophy (HP:0000092)2.00679998
72Constricted visual fields (HP:0001133)1.98462406
73Progressive microcephaly (HP:0000253)1.97433583
74Median cleft lip (HP:0000161)1.97084307
75Type II diabetes mellitus (HP:0005978)1.95732194
76Abolished electroretinogram (ERG) (HP:0000550)1.94848677
77Glycosuria (HP:0003076)1.93036358
78Abnormality of urine glucose concentration (HP:0011016)1.93036358
79Chronic bronchitis (HP:0004469)1.88809665
80Male pseudohermaphroditism (HP:0000037)1.85770602
81Increased corneal curvature (HP:0100692)1.82907136
82Keratoconus (HP:0000563)1.82907136
83Spastic paraparesis (HP:0002313)1.82487622
84Myokymia (HP:0002411)1.82279765
85Dyskinesia (HP:0100660)1.81146759
86Bronchiectasis (HP:0002110)1.76674562
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75790665
88Optic disc pallor (HP:0000543)1.75719958
89Hypoalphalipoproteinemia (HP:0003233)1.75552496
90Congenital, generalized hypertrichosis (HP:0004540)1.73814723
91Abnormality of serum amino acid levels (HP:0003112)1.68778537
92Abnormality of potassium homeostasis (HP:0011042)1.68701923
93Abnormality of T cell physiology (HP:0011840)1.67519140
94Postaxial foot polydactyly (HP:0001830)1.66336423
95Optic nerve hypoplasia (HP:0000609)1.65678984
96Abnormality of the renal cortex (HP:0011035)1.64384497
97Renal dysplasia (HP:0000110)1.64334973
98Anencephaly (HP:0002323)1.62461105
99Cystic liver disease (HP:0006706)1.61448389
100Sensory axonal neuropathy (HP:0003390)1.61283863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.55904246
2MAP4K24.94774917
3CDK194.89172058
4PLK23.54322982
5INSRR3.43089881
6TESK13.22643114
7DDR22.87100257
8STK382.18954732
9PINK12.16430344
10WNK42.04430912
11ACVR1B1.65697772
12MAPK151.59299629
13PNCK1.51885620
14BMPR1B1.49829526
15FRK1.47702627
16MUSK1.40886763
17ADRBK21.40199832
18TLK11.37780477
19STK38L1.36611683
20BRD41.35246293
21PTK2B1.28981104
22MAP3K111.25745206
23DYRK1B1.21986551
24ZAK1.20567556
25AKT31.15199270
26TAOK31.08639322
27WNK11.05765123
28CDK71.00542195
29OXSR10.96190993
30SGK4940.93632420
31SGK2230.93632420
32PDK10.90763483
33PIK3CG0.88661283
34UHMK10.82620664
35MARK30.82004679
36MST1R0.81401023
37PDPK10.78405050
38CAMK1G0.78363521
39GRK10.78067135
40NEK60.77561648
41PRKD30.75340165
42JAK30.73667181
43TXK0.72232592
44TIE10.72034297
45DYRK20.71474502
46ROCK10.70993112
47PRKG10.70507917
48TEC0.69604810
49TYRO30.68935564
50PRKG20.64502057
51STK390.62736277
52SIK20.60901198
53PRKCE0.60505548
54MAP3K30.59336561
55MAPK130.57040257
56ITK0.56107877
57CDK30.55309349
58MAP3K40.54519060
59NME10.53935453
60RPS6KA50.52428102
61MYLK0.50761093
62MAP4K10.50725579
63MAP2K20.50452060
64KIT0.50011415
65OBSCN0.49110294
66RPS6KA10.48057903
67PHKG20.47985112
68PHKG10.47985112
69SGK20.47599833
70DAPK20.47544960
71PRKACA0.47296622
72CDK90.45865098
73CAMK10.45122160
74PRKCG0.44661580
75FES0.44232286
76PRKCQ0.43833570
77RPS6KA60.42927550
78PKN10.40686734
79CSF1R0.40497378
80VRK10.39708421
81KDR0.39626982
82MAP2K70.39167645
83WNK30.39130290
84ADRBK10.39104337
85SYK0.38941274
86CCNB10.37787165
87SGK10.36037447
88PRKCH0.35947640
89RPS6KA20.35487107
90IKBKB0.34833809
91RPS6KL10.34159117
92RPS6KC10.34159117
93CSNK1A10.34039729
94PRKCA0.33713205
95ABL20.33705632
96CAMK2A0.30415234
97NTRK20.30012716
98GRK60.29698054
99LYN0.28808209
100PRKCI0.26073630

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.92420972
2Olfactory transduction_Homo sapiens_hsa047403.18781278
3Fatty acid biosynthesis_Homo sapiens_hsa000612.69418578
4Butanoate metabolism_Homo sapiens_hsa006502.62360691
5Allograft rejection_Homo sapiens_hsa053302.58271289
6Graft-versus-host disease_Homo sapiens_hsa053322.51051246
7Autoimmune thyroid disease_Homo sapiens_hsa053202.50735439
8Type I diabetes mellitus_Homo sapiens_hsa049402.47324392
9Antigen processing and presentation_Homo sapiens_hsa046121.94729654
10Linoleic acid metabolism_Homo sapiens_hsa005911.91094914
11Phototransduction_Homo sapiens_hsa047441.84058541
12Nitrogen metabolism_Homo sapiens_hsa009101.82503688
13Taste transduction_Homo sapiens_hsa047421.79203188
14Oxidative phosphorylation_Homo sapiens_hsa001901.69828030
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66443032
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.61553704
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.53315124
18Morphine addiction_Homo sapiens_hsa050321.52815625
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.49940424
20Cardiac muscle contraction_Homo sapiens_hsa042601.46525196
21Nicotine addiction_Homo sapiens_hsa050331.45988735
22Asthma_Homo sapiens_hsa053101.45007576
23Proteasome_Homo sapiens_hsa030501.44381174
24Selenocompound metabolism_Homo sapiens_hsa004501.40546074
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36781361
26Huntingtons disease_Homo sapiens_hsa050161.32470685
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25175200
28Parkinsons disease_Homo sapiens_hsa050121.23897607
29Salivary secretion_Homo sapiens_hsa049701.22354987
30Fat digestion and absorption_Homo sapiens_hsa049751.17818661
31RNA transport_Homo sapiens_hsa030131.17783558
32Viral myocarditis_Homo sapiens_hsa054161.16599233
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14836976
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11894455
35Ether lipid metabolism_Homo sapiens_hsa005651.10243240
36One carbon pool by folate_Homo sapiens_hsa006701.06328753
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05364973
38Collecting duct acid secretion_Homo sapiens_hsa049661.03230454
39Arginine biosynthesis_Homo sapiens_hsa002200.98749914
40Circadian entrainment_Homo sapiens_hsa047130.97940650
41Retinol metabolism_Homo sapiens_hsa008300.97502783
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95652778
43GABAergic synapse_Homo sapiens_hsa047270.94490620
44Chemical carcinogenesis_Homo sapiens_hsa052040.90422532
45Basal transcription factors_Homo sapiens_hsa030220.90331678
46Fanconi anemia pathway_Homo sapiens_hsa034600.88027705
47Alzheimers disease_Homo sapiens_hsa050100.86119649
48Arachidonic acid metabolism_Homo sapiens_hsa005900.85074497
49Homologous recombination_Homo sapiens_hsa034400.84915834
50Serotonergic synapse_Homo sapiens_hsa047260.82391838
51Arginine and proline metabolism_Homo sapiens_hsa003300.80583565
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79276403
53Sulfur metabolism_Homo sapiens_hsa009200.78876604
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78871252
55Synaptic vesicle cycle_Homo sapiens_hsa047210.78545769
56Phenylalanine metabolism_Homo sapiens_hsa003600.78309566
57Glycerolipid metabolism_Homo sapiens_hsa005610.75800256
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73330235
59Glutamatergic synapse_Homo sapiens_hsa047240.70370360
60Tyrosine metabolism_Homo sapiens_hsa003500.69790994
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.69696260
62Systemic lupus erythematosus_Homo sapiens_hsa053220.68483983
63Purine metabolism_Homo sapiens_hsa002300.67680241
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67272152
65Calcium signaling pathway_Homo sapiens_hsa040200.66630690
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63206863
67Primary immunodeficiency_Homo sapiens_hsa053400.61515813
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61326129
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60891580
70Peroxisome_Homo sapiens_hsa041460.60674932
71Tryptophan metabolism_Homo sapiens_hsa003800.59524427
72RNA degradation_Homo sapiens_hsa030180.59360971
73ABC transporters_Homo sapiens_hsa020100.58308717
74Propanoate metabolism_Homo sapiens_hsa006400.57802489
75Rheumatoid arthritis_Homo sapiens_hsa053230.57774660
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54616186
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53817388
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53815773
79Pancreatic secretion_Homo sapiens_hsa049720.53504127
80Regulation of autophagy_Homo sapiens_hsa041400.52947942
81Metabolic pathways_Homo sapiens_hsa011000.50382255
82Legionellosis_Homo sapiens_hsa051340.49419091
83Fatty acid degradation_Homo sapiens_hsa000710.47812269
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47601243
85Renin secretion_Homo sapiens_hsa049240.47357563
86Insulin secretion_Homo sapiens_hsa049110.45695926
87Hedgehog signaling pathway_Homo sapiens_hsa043400.44286817
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41630290
89Caffeine metabolism_Homo sapiens_hsa002320.41607442
90Gastric acid secretion_Homo sapiens_hsa049710.40986092
91Sulfur relay system_Homo sapiens_hsa041220.40948329
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40801991
93Cholinergic synapse_Homo sapiens_hsa047250.40753596
94Alcoholism_Homo sapiens_hsa050340.38625827
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.38412878
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37852518
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37688863
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37225997
99Dorso-ventral axis formation_Homo sapiens_hsa043200.35655768
100Ribosome_Homo sapiens_hsa030100.32531219

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »