Rank | Gene Set | Z-score |
---|---|---|
1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.69898964 |
2 | regulation of ARF GTPase activity (GO:0032312) | 4.61664133 |
3 | regulation of gamma-delta T cell activation (GO:0046643) | 4.19959903 |
4 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.19596345 |
5 | thymic T cell selection (GO:0045061) | 4.13136373 |
6 | negative thymic T cell selection (GO:0045060) | 4.11757387 |
7 | positive regulation of granulocyte differentiation (GO:0030854) | 4.11298234 |
8 | negative T cell selection (GO:0043383) | 3.95962572 |
9 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.89788083 |
10 | histone H3-K36 demethylation (GO:0070544) | 3.89441886 |
11 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.87424451 |
12 | negative regulation of cell killing (GO:0031342) | 3.87424451 |
13 | mannose metabolic process (GO:0006013) | 3.80018212 |
14 | positive thymic T cell selection (GO:0045059) | 3.78978218 |
15 | response to muramyl dipeptide (GO:0032495) | 3.76231035 |
16 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.74687349 |
17 | T cell selection (GO:0045058) | 3.68617977 |
18 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.64804588 |
19 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.63669463 |
20 | histone H3-K4 trimethylation (GO:0080182) | 3.63423478 |
21 | germinal center formation (GO:0002467) | 3.57392216 |
22 | histone H3-K9 demethylation (GO:0033169) | 3.57164237 |
23 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.51976442 |
24 | positive regulation of histone deacetylation (GO:0031065) | 3.51511389 |
25 | regulation of histone H3-K27 methylation (GO:0061085) | 3.50489207 |
26 | positive T cell selection (GO:0043368) | 3.45841549 |
27 | negative regulation of myotube differentiation (GO:0010832) | 3.43150798 |
28 | positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360 | 3.42473217 |
29 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.40847602 |
30 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.33496845 |
31 | regulation of granulocyte differentiation (GO:0030852) | 3.33274926 |
32 | establishment of protein localization to Golgi (GO:0072600) | 3.29227204 |
33 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.27917564 |
34 | positive regulation of CREB transcription factor activity (GO:0032793) | 3.27457516 |
35 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 3.27184929 |
36 | protein targeting to Golgi (GO:0000042) | 3.22316935 |
37 | histone lysine demethylation (GO:0070076) | 3.17115896 |
38 | histone H3-K9 modification (GO:0061647) | 3.16047255 |
39 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.15338369 |
40 | histone H3-K4 methylation (GO:0051568) | 3.13571632 |
41 | histone demethylation (GO:0016577) | 3.07486812 |
42 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.98714276 |
43 | leukocyte aggregation (GO:0070486) | 2.97238711 |
44 | response to interleukin-15 (GO:0070672) | 2.96745073 |
45 | B cell receptor signaling pathway (GO:0050853) | 2.94993940 |
46 | positive regulation of protein deacetylation (GO:0090312) | 2.93376840 |
47 | positive regulation of Rap GTPase activity (GO:0032854) | 2.88320178 |
48 | epithelial structure maintenance (GO:0010669) | 2.81852216 |
49 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.81194868 |
50 | NIK/NF-kappaB signaling (GO:0038061) | 2.77077002 |
51 | negative regulation of granulocyte differentiation (GO:0030853) | 2.76098367 |
52 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.74995637 |
53 | regulation of ARF protein signal transduction (GO:0032012) | 2.74751693 |
54 | detection of bacterium (GO:0016045) | 2.72904343 |
55 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.66131462 |
56 | histone lysine methylation (GO:0034968) | 2.61929553 |
57 | protein dealkylation (GO:0008214) | 2.61710738 |
58 | protein demethylation (GO:0006482) | 2.61710738 |
59 | Peyers patch development (GO:0048541) | 2.59456464 |
60 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.59456464 |
61 | detection of other organism (GO:0098543) | 2.57236806 |
62 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.57084797 |
63 | positive regulation of B cell differentiation (GO:0045579) | 2.56500842 |
64 | histone H3-K9 methylation (GO:0051567) | 2.56426414 |
65 | cellular response to interleukin-15 (GO:0071350) | 2.56328028 |
66 | regulation of B cell differentiation (GO:0045577) | 2.56164772 |
67 | peptidyl-lysine trimethylation (GO:0018023) | 2.54724533 |
68 | tolerance induction (GO:0002507) | 2.54343386 |
69 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.53999305 |
70 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.53999305 |
71 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.52292150 |
72 | macrophage activation involved in immune response (GO:0002281) | 2.52006800 |
73 | negative regulation of histone methylation (GO:0031061) | 2.51123147 |
74 | dendritic cell chemotaxis (GO:0002407) | 2.50905761 |
75 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.50752031 |
76 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.50630031 |
77 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.49402236 |
78 | histone H4 deacetylation (GO:0070933) | 2.48716359 |
79 | defense response to protozoan (GO:0042832) | 2.48000372 |
80 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.47113832 |
81 | regulation of T cell tolerance induction (GO:0002664) | 2.45628230 |
82 | activation of JUN kinase activity (GO:0007257) | 2.44722910 |
83 | response to type I interferon (GO:0034340) | 2.44436800 |
84 | phospholipid scrambling (GO:0017121) | 2.43654308 |
85 | megakaryocyte development (GO:0035855) | 2.42738104 |
86 | activated T cell proliferation (GO:0050798) | 2.41376080 |
87 | positive regulation of alpha-beta T cell differentiation (GO:0046638) | 2.40383845 |
88 | positive regulation of protein kinase C signaling (GO:0090037) | 2.39498482 |
89 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.39100252 |
90 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.38362272 |
91 | regulation of alpha-beta T cell differentiation (GO:0046637) | 2.37717122 |
92 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.37610235 |
93 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.37610235 |
94 | modulation by symbiont of host immune response (GO:0052553) | 2.37610235 |
95 | positive regulation by symbiont of host defense response (GO:0052509) | 2.37610235 |
96 | modulation by symbiont of host defense response (GO:0052031) | 2.37610235 |
97 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.37610235 |
98 | coronary vasculature morphogenesis (GO:0060977) | 2.37112412 |
99 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.34617451 |
100 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.34398727 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.83229498 |
2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.32552004 |
3 | MYC_22102868_ChIP-Seq_BL_Human | 3.08668359 |
4 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.77318948 |
5 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.72848027 |
6 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.58246889 |
7 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.55145582 |
8 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.51860093 |
9 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.48216055 |
10 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.46673686 |
11 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.45157220 |
12 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.41776268 |
13 | KDM2B_26808549_Chip-Seq_DND41_Human | 2.38509579 |
14 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.32075600 |
15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.27435315 |
16 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.25709012 |
17 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.25515066 |
18 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.21797084 |
19 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.21346810 |
20 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.21339524 |
21 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.17660174 |
22 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.13594460 |
23 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.07413464 |
24 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.05418728 |
25 | MAF_26560356_Chip-Seq_TH1_Human | 2.04857028 |
26 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.02566004 |
27 | UTX_26944678_Chip-Seq_JUKART_Human | 1.97077015 |
28 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.97008140 |
29 | SPI1_23127762_ChIP-Seq_K562_Human | 1.95769886 |
30 | MAF_26560356_Chip-Seq_TH2_Human | 1.88274706 |
31 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.88236312 |
32 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.86375847 |
33 | MYB_26560356_Chip-Seq_TH2_Human | 1.82403631 |
34 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.76651165 |
35 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.73594623 |
36 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.70247230 |
37 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.68530494 |
38 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.68405405 |
39 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.67949019 |
40 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.66956975 |
41 | MYB_26560356_Chip-Seq_TH1_Human | 1.65166516 |
42 | KDM2B_26808549_Chip-Seq_K562_Human | 1.62447364 |
43 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62231887 |
44 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.60266299 |
45 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.50764376 |
46 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.47325345 |
47 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.46813516 |
48 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.43932503 |
49 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.42932052 |
50 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.42316141 |
51 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.41300164 |
52 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.38768028 |
53 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.37885310 |
54 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.37508502 |
55 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.36175399 |
56 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.35081492 |
57 | P68_20966046_ChIP-Seq_HELA_Human | 1.34419476 |
58 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.33722187 |
59 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.32063883 |
60 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.30909099 |
61 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.29569377 |
62 | GATA1_19941826_ChIP-Seq_K562_Human | 1.29328979 |
63 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.27729814 |
64 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.27226126 |
65 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.26295043 |
66 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.25365046 |
67 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.19487186 |
68 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.18638691 |
69 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.15901341 |
70 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.14938154 |
71 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.13636889 |
72 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.13364479 |
73 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.12071235 |
74 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.12016476 |
75 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.10499557 |
76 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.08421749 |
77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.07300557 |
78 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.07193925 |
79 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.06572966 |
80 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.06275947 |
81 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04720055 |
82 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.04384060 |
83 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.04321617 |
84 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.03799485 |
85 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.03373792 |
86 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.03251227 |
87 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.01766551 |
88 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.00607339 |
89 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.00162119 |
90 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.96005246 |
91 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.95871458 |
92 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.94268926 |
93 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.92799967 |
94 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.91442514 |
95 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.90853157 |
96 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.89812551 |
97 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.89623149 |
98 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87712074 |
99 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.87326606 |
100 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.86910173 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003172_abnormal_lysosome_physiology | 3.43720966 |
2 | MP0003763_abnormal_thymus_physiology | 3.40553699 |
3 | MP0003436_decreased_susceptibility_to | 3.19960933 |
4 | MP0001835_abnormal_antigen_presentation | 2.99970973 |
5 | MP0003303_peritoneal_inflammation | 2.91410787 |
6 | MP0001800_abnormal_humoral_immune | 2.70377801 |
7 | MP0003183_abnormal_peptide_metabolism | 2.63901564 |
8 | MP0009278_abnormal_bone_marrow | 2.44447352 |
9 | MP0001790_abnormal_immune_system | 2.44307269 |
10 | MP0005387_immune_system_phenotype | 2.44307269 |
11 | MP0005076_abnormal_cell_differentiation | 2.25465399 |
12 | MP0005000_abnormal_immune_tolerance | 2.20846768 |
13 | MP0000685_abnormal_immune_system | 2.20225255 |
14 | MP0002396_abnormal_hematopoietic_system | 2.19453209 |
15 | MP0005671_abnormal_response_to | 2.17370388 |
16 | MP0002723_abnormal_immune_serum | 2.08623617 |
17 | MP0004381_abnormal_hair_follicle | 2.07825488 |
18 | MP0010155_abnormal_intestine_physiology | 2.04735446 |
19 | MP0004947_skin_inflammation | 2.03207924 |
20 | MP0003866_abnormal_defecation | 2.02564344 |
21 | MP0002420_abnormal_adaptive_immunity | 2.01710141 |
22 | MP0005025_abnormal_response_to | 1.99957985 |
23 | MP0001819_abnormal_immune_cell | 1.99519376 |
24 | MP0002398_abnormal_bone_marrow | 1.98896561 |
25 | MP0001873_stomach_inflammation | 1.96740601 |
26 | MP0002452_abnormal_antigen_presenting | 1.96650577 |
27 | MP0003724_increased_susceptibility_to | 1.91833856 |
28 | MP0000703_abnormal_thymus_morphology | 1.89519607 |
29 | MP0002419_abnormal_innate_immunity | 1.86570141 |
30 | MP0002405_respiratory_system_inflammati | 1.83061227 |
31 | MP0005058_abnormal_lysosome_morphology | 1.82656241 |
32 | MP0000716_abnormal_immune_system | 1.71593053 |
33 | MP0003300_gastrointestinal_ulcer | 1.69837099 |
34 | MP0003045_fibrosis | 1.67295765 |
35 | MP0008260_abnormal_autophagy | 1.60630166 |
36 | MP0003705_abnormal_hypodermis_morpholog | 1.58293835 |
37 | MP0002933_joint_inflammation | 1.56199373 |
38 | MP0002138_abnormal_hepatobiliary_system | 1.51542600 |
39 | MP0000465_gastrointestinal_hemorrhage | 1.49492485 |
40 | MP0002722_abnormal_immune_system | 1.49087458 |
41 | MP0005397_hematopoietic_system_phenotyp | 1.47368619 |
42 | MP0001545_abnormal_hematopoietic_system | 1.47368619 |
43 | MP0005409_darkened_coat_color | 1.46536826 |
44 | MP0005310_abnormal_salivary_gland | 1.45714237 |
45 | MP0008004_abnormal_stomach_pH | 1.44872339 |
46 | MP0004808_abnormal_hematopoietic_stem | 1.42594889 |
47 | MP0009785_altered_susceptibility_to | 1.39005362 |
48 | MP0002429_abnormal_blood_cell | 1.36652290 |
49 | MP0000689_abnormal_spleen_morphology | 1.35482029 |
50 | MP0004264_abnormal_extraembryonic_tissu | 1.32567087 |
51 | MP0003091_abnormal_cell_migration | 1.27817927 |
52 | MP0009333_abnormal_splenocyte_physiolog | 1.22592620 |
53 | MP0003279_aneurysm | 1.21304215 |
54 | MP0001533_abnormal_skeleton_physiology | 1.17592674 |
55 | MP0001851_eye_inflammation | 1.16557976 |
56 | MP0002166_altered_tumor_susceptibility | 1.16185714 |
57 | MP0003878_abnormal_ear_physiology | 1.15943790 |
58 | MP0005377_hearing/vestibular/ear_phenot | 1.15943790 |
59 | MP0002998_abnormal_bone_remodeling | 1.15188727 |
60 | MP0002148_abnormal_hypersensitivity_rea | 1.14378577 |
61 | MP0001849_ear_inflammation | 1.14111857 |
62 | MP0001663_abnormal_digestive_system | 1.13416066 |
63 | MP0004043_abnormal_pH_regulation | 1.08801855 |
64 | MP0004510_myositis | 1.06372358 |
65 | MP0001845_abnormal_inflammatory_respons | 1.05230252 |
66 | MP0005464_abnormal_platelet_physiology | 1.04658617 |
67 | MP0002132_abnormal_respiratory_system | 1.01847703 |
68 | MP0000858_altered_metastatic_potential | 0.99965808 |
69 | MP0005670_abnormal_white_adipose | 0.98842229 |
70 | MP0002249_abnormal_larynx_morphology | 0.98385864 |
71 | MP0009115_abnormal_fat_cell | 0.98302237 |
72 | MP0000678_abnormal_parathyroid_gland | 0.97568396 |
73 | MP0005451_abnormal_body_composition | 0.88070828 |
74 | MP0005666_abnormal_adipose_tissue | 0.87438833 |
75 | MP0001348_abnormal_lacrimal_gland | 0.86021884 |
76 | MP0005381_digestive/alimentary_phenotyp | 0.83948122 |
77 | MP0005375_adipose_tissue_phenotype | 0.83353433 |
78 | MP0009384_cardiac_valve_regurgitation | 0.81400935 |
79 | MP0002009_preneoplasia | 0.81221508 |
80 | MP0000569_abnormal_digit_pigmentation | 0.81001944 |
81 | MP0008057_abnormal_DNA_replication | 0.79663610 |
82 | MP0002970_abnormal_white_adipose | 0.78585059 |
83 | MP0006082_CNS_inflammation | 0.77631222 |
84 | MP0008469_abnormal_protein_level | 0.77068774 |
85 | MP0001765_abnormal_ion_homeostasis | 0.75817608 |
86 | MP0010307_abnormal_tumor_latency | 0.75604198 |
87 | MP0003453_abnormal_keratinocyte_physiol | 0.74836517 |
88 | MP0009931_abnormal_skin_appearance | 0.74424026 |
89 | MP0003879_abnormal_hair_cell | 0.72217630 |
90 | MP0001502_abnormal_circadian_rhythm | 0.72179696 |
91 | MP0000003_abnormal_adipose_tissue | 0.70236005 |
92 | MP0000249_abnormal_blood_vessel | 0.69961045 |
93 | MP0001853_heart_inflammation | 0.69549164 |
94 | MP0010630_abnormal_cardiac_muscle | 0.69143373 |
95 | MP0003943_abnormal_hepatobiliary_system | 0.69086020 |
96 | MP0005621_abnormal_cell_physiology | 0.68829158 |
97 | MP0002168_other_aberrant_phenotype | 0.67100526 |
98 | MP0008961_abnormal_basal_metabolism | 0.66958908 |
99 | MP0003690_abnormal_glial_cell | 0.66937296 |
100 | MP0002254_reproductive_system_inflammat | 0.65911324 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of the fingertips (HP:0001211) | 5.19674476 |
2 | Obstructive sleep apnea (HP:0002870) | 3.83002999 |
3 | Colitis (HP:0002583) | 3.63434658 |
4 | Broad face (HP:0000283) | 3.30136257 |
5 | Cerebral aneurysm (HP:0004944) | 3.00658183 |
6 | Gastrointestinal inflammation (HP:0004386) | 2.99087876 |
7 | Inflammation of the large intestine (HP:0002037) | 2.95858710 |
8 | Myositis (HP:0100614) | 2.85808410 |
9 | Panhypogammaglobulinemia (HP:0003139) | 2.81288358 |
10 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.68166997 |
11 | Abnormality of the columella (HP:0009929) | 2.67223736 |
12 | Eczematoid dermatitis (HP:0000976) | 2.63391594 |
13 | Pustule (HP:0200039) | 2.62113482 |
14 | Optic neuritis (HP:0100653) | 2.60800327 |
15 | Retrobulbar optic neuritis (HP:0100654) | 2.60800327 |
16 | Long eyelashes (HP:0000527) | 2.59599984 |
17 | Papilledema (HP:0001085) | 2.58698531 |
18 | Genetic anticipation (HP:0003743) | 2.58063912 |
19 | Recurrent fungal infections (HP:0002841) | 2.54150578 |
20 | Orchitis (HP:0100796) | 2.51791891 |
21 | Dislocated radial head (HP:0003083) | 2.50332711 |
22 | Prolonged bleeding time (HP:0003010) | 2.50167055 |
23 | Increased IgE level (HP:0003212) | 2.43134406 |
24 | Agammaglobulinemia (HP:0004432) | 2.38251384 |
25 | Hypoplastic ischia (HP:0003175) | 2.36533155 |
26 | Hemorrhage of the eye (HP:0011885) | 2.35925199 |
27 | Vasculitis (HP:0002633) | 2.35499208 |
28 | Gastrointestinal infarctions (HP:0005244) | 2.32493631 |
29 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.31797025 |
30 | Abnormality of the radial head (HP:0003995) | 2.30353801 |
31 | Abnormality of the aortic arch (HP:0012303) | 2.30174584 |
32 | Narrow palate (HP:0000189) | 2.28960243 |
33 | Emphysema (HP:0002097) | 2.27476713 |
34 | Meningitis (HP:0001287) | 2.26249649 |
35 | Malnutrition (HP:0004395) | 2.26219535 |
36 | Hyperkalemia (HP:0002153) | 2.22614302 |
37 | Thin bony cortex (HP:0002753) | 2.21225436 |
38 | Mild short stature (HP:0003502) | 2.19777430 |
39 | Gastrointestinal stroma tumor (HP:0100723) | 2.19567024 |
40 | Supernumerary ribs (HP:0005815) | 2.13553064 |
41 | Abnormality of incisor morphology (HP:0011063) | 2.12955977 |
42 | Trigonocephaly (HP:0000243) | 2.12866757 |
43 | Heterotopia (HP:0002282) | 2.11807116 |
44 | Recurrent viral infections (HP:0004429) | 2.10177332 |
45 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 2.09977789 |
46 | Abnormality of the nasal septum (HP:0000419) | 2.08966824 |
47 | Autoimmune hemolytic anemia (HP:0001890) | 2.04580394 |
48 | Gingivitis (HP:0000230) | 2.03663907 |
49 | Recurrent cutaneous fungal infections (HP:0011370) | 2.01472171 |
50 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.01472171 |
51 | Peritonitis (HP:0002586) | 2.00529524 |
52 | Spondylolisthesis (HP:0003302) | 2.00086844 |
53 | Encephalitis (HP:0002383) | 1.99890985 |
54 | Abnormality of the peritoneum (HP:0002585) | 1.99721942 |
55 | Nuclear cataract (HP:0100018) | 1.98191911 |
56 | Slow saccadic eye movements (HP:0000514) | 1.98040778 |
57 | Pulmonary infiltrates (HP:0002113) | 1.97543687 |
58 | Granulocytopenia (HP:0001913) | 1.96711887 |
59 | Cellulitis (HP:0100658) | 1.90664033 |
60 | Abnormality of the ischium (HP:0003174) | 1.89880026 |
61 | Severe combined immunodeficiency (HP:0004430) | 1.89046888 |
62 | Chronic diarrhea (HP:0002028) | 1.89041270 |
63 | Hemoptysis (HP:0002105) | 1.87671842 |
64 | Biconcave vertebral bodies (HP:0004586) | 1.87192688 |
65 | Keratoconjunctivitis sicca (HP:0001097) | 1.86671277 |
66 | Neonatal short-limb short stature (HP:0008921) | 1.86444293 |
67 | Lymphopenia (HP:0001888) | 1.86233009 |
68 | Stomatitis (HP:0010280) | 1.86166710 |
69 | Restrictive lung disease (HP:0002091) | 1.82865646 |
70 | Truncal obesity (HP:0001956) | 1.82797887 |
71 | Aneurysm (HP:0002617) | 1.82035943 |
72 | Recurrent bacterial skin infections (HP:0005406) | 1.81193750 |
73 | Abnormality of the thoracic spine (HP:0100711) | 1.80231996 |
74 | Broad palm (HP:0001169) | 1.79685299 |
75 | J-shaped sella turcica (HP:0002680) | 1.79612462 |
76 | Autoimmune thrombocytopenia (HP:0001973) | 1.79580961 |
77 | Distal upper limb amyotrophy (HP:0007149) | 1.78276354 |
78 | Upper limb amyotrophy (HP:0009129) | 1.78276354 |
79 | Hyperacusis (HP:0010780) | 1.77819175 |
80 | Urethral obstruction (HP:0000796) | 1.76680240 |
81 | Thoracic kyphosis (HP:0002942) | 1.73743831 |
82 | Mediastinal lymphadenopathy (HP:0100721) | 1.72063821 |
83 | T lymphocytopenia (HP:0005403) | 1.71784747 |
84 | Chest pain (HP:0100749) | 1.71767141 |
85 | Abnormality of chloride homeostasis (HP:0011422) | 1.71588606 |
86 | Recurrent abscess formation (HP:0002722) | 1.70927113 |
87 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.70191711 |
88 | Metaphyseal cupping (HP:0003021) | 1.69642660 |
89 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.69219297 |
90 | Onion bulb formation (HP:0003383) | 1.68560837 |
91 | Flared iliac wings (HP:0002869) | 1.68089239 |
92 | Epistaxis (HP:0000421) | 1.66851451 |
93 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.66590594 |
94 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.65871911 |
95 | Villous atrophy (HP:0011473) | 1.65871911 |
96 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.64503912 |
97 | Tented upper lip vermilion (HP:0010804) | 1.61746682 |
98 | Abnormality of T cells (HP:0002843) | 1.61697671 |
99 | Abnormality of the pleura (HP:0002103) | 1.61640130 |
100 | Flat acetabular roof (HP:0003180) | 1.60132868 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CDK12 | 4.29764928 |
2 | MAP4K1 | 3.75483211 |
3 | TRIB3 | 2.75049105 |
4 | SIK2 | 2.60310263 |
5 | ERN1 | 2.53280625 |
6 | SIK1 | 2.32593347 |
7 | TXK | 2.27197473 |
8 | RIPK4 | 2.17520918 |
9 | FGFR4 | 2.10673157 |
10 | BLK | 2.06916527 |
11 | TNK2 | 2.06148912 |
12 | MST1R | 2.01738062 |
13 | MAP3K13 | 1.95436186 |
14 | MARK2 | 1.88605405 |
15 | WNK4 | 1.87915041 |
16 | BRD4 | 1.85298491 |
17 | CDC42BPA | 1.82433976 |
18 | SIK3 | 1.78773334 |
19 | ZAP70 | 1.75937320 |
20 | MAP3K14 | 1.74158519 |
21 | WNK1 | 1.71435049 |
22 | MAP3K7 | 1.59202115 |
23 | TYK2 | 1.42496303 |
24 | RIPK1 | 1.38003941 |
25 | FES | 1.32938241 |
26 | MAP2K3 | 1.26497020 |
27 | PRPF4B | 1.26126262 |
28 | FGFR3 | 1.23914459 |
29 | TYRO3 | 1.23023818 |
30 | BTK | 1.21116921 |
31 | CAMK1D | 1.18062621 |
32 | ICK | 1.17848041 |
33 | MARK3 | 1.15373207 |
34 | MAP2K6 | 1.11619276 |
35 | SYK | 1.09592455 |
36 | TBK1 | 1.09412917 |
37 | PRKD2 | 1.05321198 |
38 | MTOR | 1.02890620 |
39 | TAOK3 | 1.01394433 |
40 | ITK | 1.01243336 |
41 | CAMK1G | 0.99869172 |
42 | NME1 | 0.99751850 |
43 | JAK3 | 0.99483303 |
44 | JAK1 | 0.98629944 |
45 | IKBKE | 0.95270639 |
46 | NLK | 0.94709377 |
47 | GRK6 | 0.93038655 |
48 | HCK | 0.92905293 |
49 | HIPK2 | 0.90086543 |
50 | SMG1 | 0.85717657 |
51 | PKN2 | 0.84963909 |
52 | TEC | 0.81748409 |
53 | CSK | 0.81025225 |
54 | CHUK | 0.80354227 |
55 | MAPK11 | 0.80060302 |
56 | LCK | 0.79965683 |
57 | MET | 0.78984959 |
58 | TAOK1 | 0.77941624 |
59 | CSF1R | 0.77203132 |
60 | CAMKK1 | 0.74357698 |
61 | MAPK15 | 0.73711890 |
62 | EPHB1 | 0.73354109 |
63 | FGR | 0.72884639 |
64 | PRKCH | 0.72104971 |
65 | IRAK4 | 0.70546149 |
66 | KIT | 0.70214276 |
67 | ERBB2 | 0.69950006 |
68 | PDK1 | 0.69274888 |
69 | FGFR2 | 0.67869676 |
70 | CDK4 | 0.66664385 |
71 | MAP3K6 | 0.65443904 |
72 | MAPK7 | 0.65001791 |
73 | PDGFRB | 0.63653563 |
74 | EEF2K | 0.63592246 |
75 | LYN | 0.63509905 |
76 | MAP2K2 | 0.62429499 |
77 | PDPK1 | 0.60545346 |
78 | IKBKB | 0.60494844 |
79 | PRKAA2 | 0.58558242 |
80 | BMX | 0.58169681 |
81 | RPS6KL1 | 0.56351300 |
82 | RPS6KC1 | 0.56351300 |
83 | STK38 | 0.53422019 |
84 | MAP3K10 | 0.52921866 |
85 | PDGFRA | 0.52759810 |
86 | SGK3 | 0.52141394 |
87 | SGK1 | 0.49576450 |
88 | CDK9 | 0.49528527 |
89 | MAP3K3 | 0.48668729 |
90 | MAPK12 | 0.48575213 |
91 | PRKD3 | 0.47628725 |
92 | RPS6KA6 | 0.47273037 |
93 | MAP3K1 | 0.47064639 |
94 | PTK6 | 0.46858985 |
95 | SGK2 | 0.45294168 |
96 | TRPM7 | 0.45131626 |
97 | MAPK1 | 0.45083316 |
98 | MAPK3 | 0.45009280 |
99 | CAMK4 | 0.44632005 |
100 | MAPK8 | 0.43477646 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Other glycan degradation_Homo sapiens_hsa00511 | 2.20666944 |
2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.08889519 |
3 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.93903137 |
4 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.86022753 |
5 | Allograft rejection_Homo sapiens_hsa05330 | 1.85180953 |
6 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.81447451 |
7 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.80105514 |
8 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.78369973 |
9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.77657811 |
10 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.76722006 |
11 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.69453990 |
12 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.68003526 |
13 | Leishmaniasis_Homo sapiens_hsa05140 | 1.64283917 |
14 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.59572381 |
15 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.48385367 |
16 | Lysine degradation_Homo sapiens_hsa00310 | 1.38672313 |
17 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.37852874 |
18 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.36452939 |
19 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.34159399 |
20 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.29245988 |
21 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.26814698 |
22 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.25819471 |
23 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.24505494 |
24 | Asthma_Homo sapiens_hsa05310 | 1.24468307 |
25 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.23101767 |
26 | Influenza A_Homo sapiens_hsa05164 | 1.22982758 |
27 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.22525787 |
28 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.21151210 |
29 | Measles_Homo sapiens_hsa05162 | 1.20482669 |
30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.19396530 |
31 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.19120631 |
32 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.17988347 |
33 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.17138800 |
34 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.14770507 |
35 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.13536618 |
36 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.12018297 |
37 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.09914937 |
38 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.09802147 |
39 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.09281338 |
40 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.08426158 |
41 | Platelet activation_Homo sapiens_hsa04611 | 1.08057915 |
42 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.07446471 |
43 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.06592552 |
44 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.06578711 |
45 | Tuberculosis_Homo sapiens_hsa05152 | 1.05775593 |
46 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.05388578 |
47 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.05310816 |
48 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.01375250 |
49 | Malaria_Homo sapiens_hsa05144 | 1.00664001 |
50 | Long-term potentiation_Homo sapiens_hsa04720 | 1.00475707 |
51 | Insulin resistance_Homo sapiens_hsa04931 | 0.95857727 |
52 | ABC transporters_Homo sapiens_hsa02010 | 0.95672597 |
53 | Hepatitis B_Homo sapiens_hsa05161 | 0.94695508 |
54 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.93689375 |
55 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.93507645 |
56 | Viral myocarditis_Homo sapiens_hsa05416 | 0.93454320 |
57 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.91260390 |
58 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.88720894 |
59 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.86781709 |
60 | Prostate cancer_Homo sapiens_hsa05215 | 0.86668278 |
61 | Hepatitis C_Homo sapiens_hsa05160 | 0.84961123 |
62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.84768225 |
63 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.84072467 |
64 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.83529764 |
65 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.82096469 |
66 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.81614771 |
67 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.79789004 |
68 | Endometrial cancer_Homo sapiens_hsa05213 | 0.79413045 |
69 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.79076771 |
70 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.77109980 |
71 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.76672213 |
72 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.76605302 |
73 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.75774330 |
74 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.74824165 |
75 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.71446226 |
76 | Amoebiasis_Homo sapiens_hsa05146 | 0.70505455 |
77 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.70352214 |
78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.69955287 |
79 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.67327311 |
80 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67272546 |
81 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.63442355 |
82 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.62006804 |
83 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61979117 |
84 | Colorectal cancer_Homo sapiens_hsa05210 | 0.60679564 |
85 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.60552508 |
86 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.60194979 |
87 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.60102585 |
88 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59165077 |
89 | Apoptosis_Homo sapiens_hsa04210 | 0.58532638 |
90 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.57696006 |
91 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.56570506 |
92 | Glioma_Homo sapiens_hsa05214 | 0.53832422 |
93 | Pertussis_Homo sapiens_hsa05133 | 0.52827936 |
94 | Endocytosis_Homo sapiens_hsa04144 | 0.52695505 |
95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.52398911 |
96 | Salivary secretion_Homo sapiens_hsa04970 | 0.51304718 |
97 | Adherens junction_Homo sapiens_hsa04520 | 0.49394373 |
98 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.45946310 |
99 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.44153303 |
100 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.43601998 |