NPIPB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.69898964
2regulation of ARF GTPase activity (GO:0032312)4.61664133
3regulation of gamma-delta T cell activation (GO:0046643)4.19959903
4regulation of gamma-delta T cell differentiation (GO:0045586)4.19596345
5thymic T cell selection (GO:0045061)4.13136373
6negative thymic T cell selection (GO:0045060)4.11757387
7positive regulation of granulocyte differentiation (GO:0030854)4.11298234
8negative T cell selection (GO:0043383)3.95962572
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89788083
10histone H3-K36 demethylation (GO:0070544)3.89441886
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87424451
12negative regulation of cell killing (GO:0031342)3.87424451
13mannose metabolic process (GO:0006013)3.80018212
14positive thymic T cell selection (GO:0045059)3.78978218
15response to muramyl dipeptide (GO:0032495)3.76231035
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74687349
17T cell selection (GO:0045058)3.68617977
18antigen processing and presentation of endogenous antigen (GO:0019883)3.64804588
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63669463
20histone H3-K4 trimethylation (GO:0080182)3.63423478
21germinal center formation (GO:0002467)3.57392216
22histone H3-K9 demethylation (GO:0033169)3.57164237
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.51976442
24positive regulation of histone deacetylation (GO:0031065)3.51511389
25regulation of histone H3-K27 methylation (GO:0061085)3.50489207
26positive T cell selection (GO:0043368)3.45841549
27negative regulation of myotube differentiation (GO:0010832)3.43150798
28positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.42473217
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40847602
30maintenance of gastrointestinal epithelium (GO:0030277)3.33496845
31regulation of granulocyte differentiation (GO:0030852)3.33274926
32establishment of protein localization to Golgi (GO:0072600)3.29227204
33negative regulation of erythrocyte differentiation (GO:0045647)3.27917564
34positive regulation of CREB transcription factor activity (GO:0032793)3.27457516
35retrograde transport, vesicle recycling within Golgi (GO:0000301)3.27184929
36protein targeting to Golgi (GO:0000042)3.22316935
37histone lysine demethylation (GO:0070076)3.17115896
38histone H3-K9 modification (GO:0061647)3.16047255
39regulation of B cell receptor signaling pathway (GO:0050855)3.15338369
40histone H3-K4 methylation (GO:0051568)3.13571632
41histone demethylation (GO:0016577)3.07486812
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98714276
43leukocyte aggregation (GO:0070486)2.97238711
44response to interleukin-15 (GO:0070672)2.96745073
45B cell receptor signaling pathway (GO:0050853)2.94993940
46positive regulation of protein deacetylation (GO:0090312)2.93376840
47positive regulation of Rap GTPase activity (GO:0032854)2.88320178
48epithelial structure maintenance (GO:0010669)2.81852216
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.81194868
50NIK/NF-kappaB signaling (GO:0038061)2.77077002
51negative regulation of granulocyte differentiation (GO:0030853)2.76098367
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74995637
53regulation of ARF protein signal transduction (GO:0032012)2.74751693
54detection of bacterium (GO:0016045)2.72904343
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66131462
56histone lysine methylation (GO:0034968)2.61929553
57protein dealkylation (GO:0008214)2.61710738
58protein demethylation (GO:0006482)2.61710738
59Peyers patch development (GO:0048541)2.59456464
60mucosal-associated lymphoid tissue development (GO:0048537)2.59456464
61detection of other organism (GO:0098543)2.57236806
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57084797
63positive regulation of B cell differentiation (GO:0045579)2.56500842
64histone H3-K9 methylation (GO:0051567)2.56426414
65cellular response to interleukin-15 (GO:0071350)2.56328028
66regulation of B cell differentiation (GO:0045577)2.56164772
67peptidyl-lysine trimethylation (GO:0018023)2.54724533
68tolerance induction (GO:0002507)2.54343386
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53999305
70negative regulation of T-helper cell differentiation (GO:0045623)2.53999305
71regulation of T-helper 2 cell differentiation (GO:0045628)2.52292150
72macrophage activation involved in immune response (GO:0002281)2.52006800
73negative regulation of histone methylation (GO:0031061)2.51123147
74dendritic cell chemotaxis (GO:0002407)2.50905761
75Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50752031
76poly(A)+ mRNA export from nucleus (GO:0016973)2.50630031
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.49402236
78histone H4 deacetylation (GO:0070933)2.48716359
79defense response to protozoan (GO:0042832)2.48000372
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.47113832
81regulation of T cell tolerance induction (GO:0002664)2.45628230
82activation of JUN kinase activity (GO:0007257)2.44722910
83response to type I interferon (GO:0034340)2.44436800
84phospholipid scrambling (GO:0017121)2.43654308
85megakaryocyte development (GO:0035855)2.42738104
86activated T cell proliferation (GO:0050798)2.41376080
87positive regulation of alpha-beta T cell differentiation (GO:0046638)2.40383845
88positive regulation of protein kinase C signaling (GO:0090037)2.39498482
89negative regulation of alpha-beta T cell activation (GO:0046636)2.39100252
90regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38362272
91regulation of alpha-beta T cell differentiation (GO:0046637)2.37717122
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37610235
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.37610235
94modulation by symbiont of host immune response (GO:0052553)2.37610235
95positive regulation by symbiont of host defense response (GO:0052509)2.37610235
96modulation by symbiont of host defense response (GO:0052031)2.37610235
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37610235
98coronary vasculature morphogenesis (GO:0060977)2.37112412
99regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34617451
100positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.34398727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.83229498
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32552004
3MYC_22102868_ChIP-Seq_BL_Human3.08668359
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.77318948
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.72848027
6TCF7_22412390_ChIP-Seq_EML_Mouse2.58246889
7VDR_21846776_ChIP-Seq_THP-1_Human2.55145582
8DROSHA_22980978_ChIP-Seq_HELA_Human2.51860093
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.48216055
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46673686
11RUNX_20019798_ChIP-Seq_JUKART_Human2.45157220
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.41776268
13KDM2B_26808549_Chip-Seq_DND41_Human2.38509579
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.32075600
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27435315
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25709012
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25515066
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.21797084
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21346810
20SCL_19346495_ChIP-Seq_HPC-7_Human2.21339524
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.17660174
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.13594460
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07413464
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05418728
25MAF_26560356_Chip-Seq_TH1_Human2.04857028
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02566004
27UTX_26944678_Chip-Seq_JUKART_Human1.97077015
28LXR_22292898_ChIP-Seq_THP-1_Human1.97008140
29SPI1_23127762_ChIP-Seq_K562_Human1.95769886
30MAF_26560356_Chip-Seq_TH2_Human1.88274706
31VDR_24763502_ChIP-Seq_THP-1_Human1.88236312
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86375847
33MYB_26560356_Chip-Seq_TH2_Human1.82403631
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.76651165
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.73594623
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70247230
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.68530494
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.68405405
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67949019
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66956975
41MYB_26560356_Chip-Seq_TH1_Human1.65166516
42KDM2B_26808549_Chip-Seq_K562_Human1.62447364
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62231887
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.60266299
45SMC4_20622854_ChIP-Seq_HELA_Human1.50764376
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.47325345
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46813516
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.43932503
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.42932052
50RACK7_27058665_Chip-Seq_MCF-7_Human1.42316141
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41300164
52GATA3_27048872_Chip-Seq_THYMUS_Human1.38768028
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37885310
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37508502
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36175399
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35081492
57P68_20966046_ChIP-Seq_HELA_Human1.34419476
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33722187
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32063883
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30909099
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29569377
62GATA1_19941826_ChIP-Seq_K562_Human1.29328979
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.27729814
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27226126
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26295043
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25365046
67CIITA_25753668_ChIP-Seq_RAJI_Human1.19487186
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18638691
69CREB1_26743006_Chip-Seq_LNCaP_Human1.15901341
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14938154
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13636889
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.13364479
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12071235
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12016476
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10499557
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.08421749
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.07300557
78NCOR1_26117541_ChIP-Seq_K562_Human1.07193925
79BCOR_27268052_Chip-Seq_Bcells_Human1.06572966
80BCL6_27268052_Chip-Seq_Bcells_Human1.06275947
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04720055
82TP63_22573176_ChIP-Seq_HFKS_Human1.04384060
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04321617
84OCT4_19829295_ChIP-Seq_ESCs_Human1.03799485
85VDR_24787735_ChIP-Seq_THP-1_Human1.03373792
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03251227
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01766551
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00607339
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00162119
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96005246
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95871458
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94268926
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92799967
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91442514
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90853157
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89812551
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89623149
98SPI1_23547873_ChIP-Seq_NB4_Human0.87712074
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87326606
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86910173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology3.43720966
2MP0003763_abnormal_thymus_physiology3.40553699
3MP0003436_decreased_susceptibility_to3.19960933
4MP0001835_abnormal_antigen_presentation2.99970973
5MP0003303_peritoneal_inflammation2.91410787
6MP0001800_abnormal_humoral_immune2.70377801
7MP0003183_abnormal_peptide_metabolism2.63901564
8MP0009278_abnormal_bone_marrow2.44447352
9MP0001790_abnormal_immune_system2.44307269
10MP0005387_immune_system_phenotype2.44307269
11MP0005076_abnormal_cell_differentiation2.25465399
12MP0005000_abnormal_immune_tolerance2.20846768
13MP0000685_abnormal_immune_system2.20225255
14MP0002396_abnormal_hematopoietic_system2.19453209
15MP0005671_abnormal_response_to2.17370388
16MP0002723_abnormal_immune_serum2.08623617
17MP0004381_abnormal_hair_follicle2.07825488
18MP0010155_abnormal_intestine_physiology2.04735446
19MP0004947_skin_inflammation2.03207924
20MP0003866_abnormal_defecation2.02564344
21MP0002420_abnormal_adaptive_immunity2.01710141
22MP0005025_abnormal_response_to1.99957985
23MP0001819_abnormal_immune_cell1.99519376
24MP0002398_abnormal_bone_marrow1.98896561
25MP0001873_stomach_inflammation1.96740601
26MP0002452_abnormal_antigen_presenting1.96650577
27MP0003724_increased_susceptibility_to1.91833856
28MP0000703_abnormal_thymus_morphology1.89519607
29MP0002419_abnormal_innate_immunity1.86570141
30MP0002405_respiratory_system_inflammati1.83061227
31MP0005058_abnormal_lysosome_morphology1.82656241
32MP0000716_abnormal_immune_system1.71593053
33MP0003300_gastrointestinal_ulcer1.69837099
34MP0003045_fibrosis1.67295765
35MP0008260_abnormal_autophagy1.60630166
36MP0003705_abnormal_hypodermis_morpholog1.58293835
37MP0002933_joint_inflammation1.56199373
38MP0002138_abnormal_hepatobiliary_system1.51542600
39MP0000465_gastrointestinal_hemorrhage1.49492485
40MP0002722_abnormal_immune_system1.49087458
41MP0005397_hematopoietic_system_phenotyp1.47368619
42MP0001545_abnormal_hematopoietic_system1.47368619
43MP0005409_darkened_coat_color1.46536826
44MP0005310_abnormal_salivary_gland1.45714237
45MP0008004_abnormal_stomach_pH1.44872339
46MP0004808_abnormal_hematopoietic_stem1.42594889
47MP0009785_altered_susceptibility_to1.39005362
48MP0002429_abnormal_blood_cell1.36652290
49MP0000689_abnormal_spleen_morphology1.35482029
50MP0004264_abnormal_extraembryonic_tissu1.32567087
51MP0003091_abnormal_cell_migration1.27817927
52MP0009333_abnormal_splenocyte_physiolog1.22592620
53MP0003279_aneurysm1.21304215
54MP0001533_abnormal_skeleton_physiology1.17592674
55MP0001851_eye_inflammation1.16557976
56MP0002166_altered_tumor_susceptibility1.16185714
57MP0003878_abnormal_ear_physiology1.15943790
58MP0005377_hearing/vestibular/ear_phenot1.15943790
59MP0002998_abnormal_bone_remodeling1.15188727
60MP0002148_abnormal_hypersensitivity_rea1.14378577
61MP0001849_ear_inflammation1.14111857
62MP0001663_abnormal_digestive_system1.13416066
63MP0004043_abnormal_pH_regulation1.08801855
64MP0004510_myositis1.06372358
65MP0001845_abnormal_inflammatory_respons1.05230252
66MP0005464_abnormal_platelet_physiology1.04658617
67MP0002132_abnormal_respiratory_system1.01847703
68MP0000858_altered_metastatic_potential0.99965808
69MP0005670_abnormal_white_adipose0.98842229
70MP0002249_abnormal_larynx_morphology0.98385864
71MP0009115_abnormal_fat_cell0.98302237
72MP0000678_abnormal_parathyroid_gland0.97568396
73MP0005451_abnormal_body_composition0.88070828
74MP0005666_abnormal_adipose_tissue0.87438833
75MP0001348_abnormal_lacrimal_gland0.86021884
76MP0005381_digestive/alimentary_phenotyp0.83948122
77MP0005375_adipose_tissue_phenotype0.83353433
78MP0009384_cardiac_valve_regurgitation0.81400935
79MP0002009_preneoplasia0.81221508
80MP0000569_abnormal_digit_pigmentation0.81001944
81MP0008057_abnormal_DNA_replication0.79663610
82MP0002970_abnormal_white_adipose0.78585059
83MP0006082_CNS_inflammation0.77631222
84MP0008469_abnormal_protein_level0.77068774
85MP0001765_abnormal_ion_homeostasis0.75817608
86MP0010307_abnormal_tumor_latency0.75604198
87MP0003453_abnormal_keratinocyte_physiol0.74836517
88MP0009931_abnormal_skin_appearance0.74424026
89MP0003879_abnormal_hair_cell0.72217630
90MP0001502_abnormal_circadian_rhythm0.72179696
91MP0000003_abnormal_adipose_tissue0.70236005
92MP0000249_abnormal_blood_vessel0.69961045
93MP0001853_heart_inflammation0.69549164
94MP0010630_abnormal_cardiac_muscle0.69143373
95MP0003943_abnormal_hepatobiliary_system0.69086020
96MP0005621_abnormal_cell_physiology0.68829158
97MP0002168_other_aberrant_phenotype0.67100526
98MP0008961_abnormal_basal_metabolism0.66958908
99MP0003690_abnormal_glial_cell0.66937296
100MP0002254_reproductive_system_inflammat0.65911324

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.19674476
2Obstructive sleep apnea (HP:0002870)3.83002999
3Colitis (HP:0002583)3.63434658
4Broad face (HP:0000283)3.30136257
5Cerebral aneurysm (HP:0004944)3.00658183
6Gastrointestinal inflammation (HP:0004386)2.99087876
7Inflammation of the large intestine (HP:0002037)2.95858710
8Myositis (HP:0100614)2.85808410
9Panhypogammaglobulinemia (HP:0003139)2.81288358
10Abnormal delayed hypersensitivity skin test (HP:0002963)2.68166997
11Abnormality of the columella (HP:0009929)2.67223736
12Eczematoid dermatitis (HP:0000976)2.63391594
13Pustule (HP:0200039)2.62113482
14Optic neuritis (HP:0100653)2.60800327
15Retrobulbar optic neuritis (HP:0100654)2.60800327
16Long eyelashes (HP:0000527)2.59599984
17Papilledema (HP:0001085)2.58698531
18Genetic anticipation (HP:0003743)2.58063912
19Recurrent fungal infections (HP:0002841)2.54150578
20Orchitis (HP:0100796)2.51791891
21Dislocated radial head (HP:0003083)2.50332711
22Prolonged bleeding time (HP:0003010)2.50167055
23Increased IgE level (HP:0003212)2.43134406
24Agammaglobulinemia (HP:0004432)2.38251384
25Hypoplastic ischia (HP:0003175)2.36533155
26Hemorrhage of the eye (HP:0011885)2.35925199
27Vasculitis (HP:0002633)2.35499208
28Gastrointestinal infarctions (HP:0005244)2.32493631
29Supernumerary bones of the axial skeleton (HP:0009144)2.31797025
30Abnormality of the radial head (HP:0003995)2.30353801
31Abnormality of the aortic arch (HP:0012303)2.30174584
32Narrow palate (HP:0000189)2.28960243
33Emphysema (HP:0002097)2.27476713
34Meningitis (HP:0001287)2.26249649
35Malnutrition (HP:0004395)2.26219535
36Hyperkalemia (HP:0002153)2.22614302
37Thin bony cortex (HP:0002753)2.21225436
38Mild short stature (HP:0003502)2.19777430
39Gastrointestinal stroma tumor (HP:0100723)2.19567024
40Supernumerary ribs (HP:0005815)2.13553064
41Abnormality of incisor morphology (HP:0011063)2.12955977
42Trigonocephaly (HP:0000243)2.12866757
43Heterotopia (HP:0002282)2.11807116
44Recurrent viral infections (HP:0004429)2.10177332
45Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09977789
46Abnormality of the nasal septum (HP:0000419)2.08966824
47Autoimmune hemolytic anemia (HP:0001890)2.04580394
48Gingivitis (HP:0000230)2.03663907
49Recurrent cutaneous fungal infections (HP:0011370)2.01472171
50Chronic mucocutaneous candidiasis (HP:0002728)2.01472171
51Peritonitis (HP:0002586)2.00529524
52Spondylolisthesis (HP:0003302)2.00086844
53Encephalitis (HP:0002383)1.99890985
54Abnormality of the peritoneum (HP:0002585)1.99721942
55Nuclear cataract (HP:0100018)1.98191911
56Slow saccadic eye movements (HP:0000514)1.98040778
57Pulmonary infiltrates (HP:0002113)1.97543687
58Granulocytopenia (HP:0001913)1.96711887
59Cellulitis (HP:0100658)1.90664033
60Abnormality of the ischium (HP:0003174)1.89880026
61Severe combined immunodeficiency (HP:0004430)1.89046888
62Chronic diarrhea (HP:0002028)1.89041270
63Hemoptysis (HP:0002105)1.87671842
64Biconcave vertebral bodies (HP:0004586)1.87192688
65Keratoconjunctivitis sicca (HP:0001097)1.86671277
66Neonatal short-limb short stature (HP:0008921)1.86444293
67Lymphopenia (HP:0001888)1.86233009
68Stomatitis (HP:0010280)1.86166710
69Restrictive lung disease (HP:0002091)1.82865646
70Truncal obesity (HP:0001956)1.82797887
71Aneurysm (HP:0002617)1.82035943
72Recurrent bacterial skin infections (HP:0005406)1.81193750
73Abnormality of the thoracic spine (HP:0100711)1.80231996
74Broad palm (HP:0001169)1.79685299
75J-shaped sella turcica (HP:0002680)1.79612462
76Autoimmune thrombocytopenia (HP:0001973)1.79580961
77Distal upper limb amyotrophy (HP:0007149)1.78276354
78Upper limb amyotrophy (HP:0009129)1.78276354
79Hyperacusis (HP:0010780)1.77819175
80Urethral obstruction (HP:0000796)1.76680240
81Thoracic kyphosis (HP:0002942)1.73743831
82Mediastinal lymphadenopathy (HP:0100721)1.72063821
83T lymphocytopenia (HP:0005403)1.71784747
84Chest pain (HP:0100749)1.71767141
85Abnormality of chloride homeostasis (HP:0011422)1.71588606
86Recurrent abscess formation (HP:0002722)1.70927113
87Segmental peripheral demyelination/remyelination (HP:0003481)1.70191711
88Metaphyseal cupping (HP:0003021)1.69642660
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69219297
90Onion bulb formation (HP:0003383)1.68560837
91Flared iliac wings (HP:0002869)1.68089239
92Epistaxis (HP:0000421)1.66851451
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.66590594
94Abnormality of small intestinal villus morphology (HP:0011472)1.65871911
95Villous atrophy (HP:0011473)1.65871911
96Elevated erythrocyte sedimentation rate (HP:0003565)1.64503912
97Tented upper lip vermilion (HP:0010804)1.61746682
98Abnormality of T cells (HP:0002843)1.61697671
99Abnormality of the pleura (HP:0002103)1.61640130
100Flat acetabular roof (HP:0003180)1.60132868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.29764928
2MAP4K13.75483211
3TRIB32.75049105
4SIK22.60310263
5ERN12.53280625
6SIK12.32593347
7TXK2.27197473
8RIPK42.17520918
9FGFR42.10673157
10BLK2.06916527
11TNK22.06148912
12MST1R2.01738062
13MAP3K131.95436186
14MARK21.88605405
15WNK41.87915041
16BRD41.85298491
17CDC42BPA1.82433976
18SIK31.78773334
19ZAP701.75937320
20MAP3K141.74158519
21WNK11.71435049
22MAP3K71.59202115
23TYK21.42496303
24RIPK11.38003941
25FES1.32938241
26MAP2K31.26497020
27PRPF4B1.26126262
28FGFR31.23914459
29TYRO31.23023818
30BTK1.21116921
31CAMK1D1.18062621
32ICK1.17848041
33MARK31.15373207
34MAP2K61.11619276
35SYK1.09592455
36TBK11.09412917
37PRKD21.05321198
38MTOR1.02890620
39TAOK31.01394433
40ITK1.01243336
41CAMK1G0.99869172
42NME10.99751850
43JAK30.99483303
44JAK10.98629944
45IKBKE0.95270639
46NLK0.94709377
47GRK60.93038655
48HCK0.92905293
49HIPK20.90086543
50SMG10.85717657
51PKN20.84963909
52TEC0.81748409
53CSK0.81025225
54CHUK0.80354227
55MAPK110.80060302
56LCK0.79965683
57MET0.78984959
58TAOK10.77941624
59CSF1R0.77203132
60CAMKK10.74357698
61MAPK150.73711890
62EPHB10.73354109
63FGR0.72884639
64PRKCH0.72104971
65IRAK40.70546149
66KIT0.70214276
67ERBB20.69950006
68PDK10.69274888
69FGFR20.67869676
70CDK40.66664385
71MAP3K60.65443904
72MAPK70.65001791
73PDGFRB0.63653563
74EEF2K0.63592246
75LYN0.63509905
76MAP2K20.62429499
77PDPK10.60545346
78IKBKB0.60494844
79PRKAA20.58558242
80BMX0.58169681
81RPS6KL10.56351300
82RPS6KC10.56351300
83STK380.53422019
84MAP3K100.52921866
85PDGFRA0.52759810
86SGK30.52141394
87SGK10.49576450
88CDK90.49528527
89MAP3K30.48668729
90MAPK120.48575213
91PRKD30.47628725
92RPS6KA60.47273037
93MAP3K10.47064639
94PTK60.46858985
95SGK20.45294168
96TRPM70.45131626
97MAPK10.45083316
98MAPK30.45009280
99CAMK40.44632005
100MAPK80.43477646

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.20666944
2Primary immunodeficiency_Homo sapiens_hsa053402.08889519
3B cell receptor signaling pathway_Homo sapiens_hsa046621.93903137
4Acute myeloid leukemia_Homo sapiens_hsa052211.86022753
5Allograft rejection_Homo sapiens_hsa053301.85180953
6Notch signaling pathway_Homo sapiens_hsa043301.81447451
7Osteoclast differentiation_Homo sapiens_hsa043801.80105514
8Graft-versus-host disease_Homo sapiens_hsa053321.78369973
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.77657811
10T cell receptor signaling pathway_Homo sapiens_hsa046601.76722006
11Staphylococcus aureus infection_Homo sapiens_hsa051501.69453990
12Autoimmune thyroid disease_Homo sapiens_hsa053201.68003526
13Leishmaniasis_Homo sapiens_hsa051401.64283917
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59572381
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48385367
16Lysine degradation_Homo sapiens_hsa003101.38672313
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37852874
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36452939
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.34159399
20TNF signaling pathway_Homo sapiens_hsa046681.29245988
21Herpes simplex infection_Homo sapiens_hsa051681.26814698
22Toxoplasmosis_Homo sapiens_hsa051451.25819471
23Type I diabetes mellitus_Homo sapiens_hsa049401.24505494
24Asthma_Homo sapiens_hsa053101.24468307
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23101767
26Influenza A_Homo sapiens_hsa051641.22982758
27VEGF signaling pathway_Homo sapiens_hsa043701.22525787
28Chronic myeloid leukemia_Homo sapiens_hsa052201.21151210
29Measles_Homo sapiens_hsa051621.20482669
30Antigen processing and presentation_Homo sapiens_hsa046121.19396530
31Choline metabolism in cancer_Homo sapiens_hsa052311.19120631
32Dorso-ventral axis formation_Homo sapiens_hsa043201.17988347
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17138800
34Non-small cell lung cancer_Homo sapiens_hsa052231.14770507
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.13536618
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12018297
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09914937
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09802147
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09281338
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.08426158
41Platelet activation_Homo sapiens_hsa046111.08057915
42Inositol phosphate metabolism_Homo sapiens_hsa005621.07446471
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.06592552
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06578711
45Tuberculosis_Homo sapiens_hsa051521.05775593
46African trypanosomiasis_Homo sapiens_hsa051431.05388578
47Hematopoietic cell lineage_Homo sapiens_hsa046401.05310816
48GnRH signaling pathway_Homo sapiens_hsa049121.01375250
49Malaria_Homo sapiens_hsa051441.00664001
50Long-term potentiation_Homo sapiens_hsa047201.00475707
51Insulin resistance_Homo sapiens_hsa049310.95857727
52ABC transporters_Homo sapiens_hsa020100.95672597
53Hepatitis B_Homo sapiens_hsa051610.94695508
54mTOR signaling pathway_Homo sapiens_hsa041500.93689375
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93507645
56Viral myocarditis_Homo sapiens_hsa054160.93454320
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91260390
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88720894
59Pancreatic cancer_Homo sapiens_hsa052120.86781709
60Prostate cancer_Homo sapiens_hsa052150.86668278
61Hepatitis C_Homo sapiens_hsa051600.84961123
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84768225
63Chemokine signaling pathway_Homo sapiens_hsa040620.84072467
64Renal cell carcinoma_Homo sapiens_hsa052110.83529764
65Estrogen signaling pathway_Homo sapiens_hsa049150.82096469
66ErbB signaling pathway_Homo sapiens_hsa040120.81614771
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.79789004
68Endometrial cancer_Homo sapiens_hsa052130.79413045
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79076771
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.77109980
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.76672213
72Type II diabetes mellitus_Homo sapiens_hsa049300.76605302
73Prolactin signaling pathway_Homo sapiens_hsa049170.75774330
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74824165
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.71446226
76Amoebiasis_Homo sapiens_hsa051460.70505455
77FoxO signaling pathway_Homo sapiens_hsa040680.70352214
78HTLV-I infection_Homo sapiens_hsa051660.69955287
79Epstein-Barr virus infection_Homo sapiens_hsa051690.67327311
80MAPK signaling pathway_Homo sapiens_hsa040100.67272546
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63442355
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62006804
83Insulin signaling pathway_Homo sapiens_hsa049100.61979117
84Colorectal cancer_Homo sapiens_hsa052100.60679564
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.60552508
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60194979
87HIF-1 signaling pathway_Homo sapiens_hsa040660.60102585
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59165077
89Apoptosis_Homo sapiens_hsa042100.58532638
90Glucagon signaling pathway_Homo sapiens_hsa049220.57696006
91MicroRNAs in cancer_Homo sapiens_hsa052060.56570506
92Glioma_Homo sapiens_hsa052140.53832422
93Pertussis_Homo sapiens_hsa051330.52827936
94Endocytosis_Homo sapiens_hsa041440.52695505
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52398911
96Salivary secretion_Homo sapiens_hsa049700.51304718
97Adherens junction_Homo sapiens_hsa045200.49394373
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.45946310
99Rap1 signaling pathway_Homo sapiens_hsa040150.44153303
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43601998

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