NPIPB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.68733379
2sperm motility (GO:0030317)8.62361316
3response to pheromone (GO:0019236)7.59215287
4fusion of sperm to egg plasma membrane (GO:0007342)7.46606880
5establishment of protein localization to Golgi (GO:0072600)6.29907247
6sperm capacitation (GO:0048240)6.22291217
7single strand break repair (GO:0000012)6.13766641
8protein targeting to Golgi (GO:0000042)5.97879202
9spermatid development (GO:0007286)5.84291905
10multicellular organism reproduction (GO:0032504)5.77779539
11protein polyglutamylation (GO:0018095)5.74862221
12retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68083233
13plasma membrane fusion (GO:0045026)5.66501584
14chromosome condensation (GO:0030261)5.59200642
15DNA packaging (GO:0006323)5.59103526
16microtubule depolymerization (GO:0007019)5.25347364
17reproduction (GO:0000003)5.16453946
18axonemal dynein complex assembly (GO:0070286)5.12875699
19negative regulation of inclusion body assembly (GO:0090084)5.03452398
20spermatid nucleus differentiation (GO:0007289)5.03307612
21calcium ion-dependent exocytosis (GO:0017156)4.96461906
22sperm-egg recognition (GO:0035036)4.94959141
23phosphatidylethanolamine biosynthetic process (GO:0006646)4.84276126
24cellular ketone body metabolic process (GO:0046950)4.68690109
25protein localization to Golgi apparatus (GO:0034067)4.60751079
26phosphatidylethanolamine metabolic process (GO:0046337)4.53901834
27regulation of cilium movement (GO:0003352)4.45997321
28microtubule polymerization or depolymerization (GO:0031109)4.40805806
29centriole replication (GO:0007099)4.39939324
30positive regulation of Rab GTPase activity (GO:0032851)4.37386974
31regulation of Rab GTPase activity (GO:0032313)4.37386974
32negative regulation of Rho protein signal transduction (GO:0035024)4.37166847
33sexual reproduction (GO:0019953)4.29226331
34spermatogenesis (GO:0007283)4.28183187
35male gamete generation (GO:0048232)4.27564464
36cell-cell recognition (GO:0009988)4.26029072
37microtubule severing (GO:0051013)4.22802987
38cilium or flagellum-dependent cell motility (GO:0001539)4.22159123
39rRNA methylation (GO:0031167)4.17514070
40ketone body metabolic process (GO:1902224)4.13208506
41RNA destabilization (GO:0050779)4.05490778
42motile cilium assembly (GO:0044458)4.01216879
43chromatin silencing (GO:0006342)3.94040656
44gamete generation (GO:0007276)3.92094381
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85099612
46epithelial cilium movement (GO:0003351)3.83771941
47binding of sperm to zona pellucida (GO:0007339)3.74955791
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68930276
49regulation of microtubule-based movement (GO:0060632)3.56055803
50single fertilization (GO:0007338)3.53486009
51regulation of transcription involved in cell fate commitment (GO:0060850)3.52790478
52cilium movement (GO:0003341)3.52158799
53centriole assembly (GO:0098534)3.47864840
54cell wall macromolecule catabolic process (GO:0016998)3.46200214
55germ cell development (GO:0007281)3.29573613
56NAD biosynthetic process (GO:0009435)3.29548120
57cell wall macromolecule metabolic process (GO:0044036)3.29277913
58rRNA modification (GO:0000154)3.24801497
59organic cation transport (GO:0015695)3.24206824
60behavioral response to nicotine (GO:0035095)3.17527474
61seminiferous tubule development (GO:0072520)3.17479125
62regulation of somitogenesis (GO:0014807)3.17348763
63multicellular organismal reproductive process (GO:0048609)3.10434436
64multicellular organismal movement (GO:0050879)3.09841117
65musculoskeletal movement (GO:0050881)3.09841117
66regulation of inclusion body assembly (GO:0090083)3.09354273
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.06591149
68negative regulation of gene expression, epigenetic (GO:0045814)3.04749566
69nephron epithelium morphogenesis (GO:0072088)3.01373262
70nephron tubule morphogenesis (GO:0072078)3.01373262
71coenzyme catabolic process (GO:0009109)2.95969105
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84247777
73fertilization (GO:0009566)2.82295493
74spinal cord motor neuron differentiation (GO:0021522)2.77996735
75axoneme assembly (GO:0035082)2.71597732
76cranial nerve morphogenesis (GO:0021602)2.69831767
77regulation of ARF GTPase activity (GO:0032312)2.69018290
78histone H3-K4 trimethylation (GO:0080182)2.68869534
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67784881
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.67784881
81regulation of translation, ncRNA-mediated (GO:0045974)2.67784881
82negative regulation of granulocyte differentiation (GO:0030853)2.67664026
83microtubule nucleation (GO:0007020)2.67280477
84peptidyl-threonine dephosphorylation (GO:0035970)2.65900342
85histone H3-K9 demethylation (GO:0033169)2.64046266
86neurofilament cytoskeleton organization (GO:0060052)2.56350115
87nucleus organization (GO:0006997)2.55911594
88membrane depolarization during action potential (GO:0086010)2.54433669
89urinary tract smooth muscle contraction (GO:0014848)2.53382769
90regulation of centriole replication (GO:0046599)2.52634791
91positive regulation of action potential (GO:0045760)2.51928677
92positive regulation of histone deacetylation (GO:0031065)2.50542946
93cerebral cortex neuron differentiation (GO:0021895)2.49127254
94pattern specification involved in kidney development (GO:0061004)2.44991138
95nicotinamide nucleotide biosynthetic process (GO:0019359)2.43920744
96pyridine nucleotide biosynthetic process (GO:0019363)2.43920744
97vesicle transport along microtubule (GO:0047496)2.43492719
98regulation of establishment of cell polarity (GO:2000114)2.42003601
99detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.41242731
100limb development (GO:0060173)2.39417605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59459417
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72150076
3DROSHA_22980978_ChIP-Seq_HELA_Human2.33012684
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30999561
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.30999561
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28365787
7CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89339305
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87850024
9CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84321992
10CBP_20019798_ChIP-Seq_JUKART_Human1.82768139
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82768139
12ZNF274_21170338_ChIP-Seq_K562_Hela1.74249520
13VDR_22108803_ChIP-Seq_LS180_Human1.69824716
14ER_23166858_ChIP-Seq_MCF-7_Human1.69524525
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.65586688
16WDR5_24793694_ChIP-Seq_LNCAP_Human1.61916020
17ERA_21632823_ChIP-Seq_H3396_Human1.53871286
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53637797
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53186323
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49868409
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49353195
22AR_21572438_ChIP-Seq_LNCaP_Human1.48477268
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48035870
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.46209811
25RUNX_20019798_ChIP-Seq_JUKART_Human1.43200693
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42314769
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.41357246
28ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40984853
29REST_21632747_ChIP-Seq_MESCs_Mouse1.38929412
30FUS_26573619_Chip-Seq_HEK293_Human1.38793862
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38712922
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37892455
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37813936
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36267989
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35359356
36AR_25329375_ChIP-Seq_VCAP_Human1.33679880
37GBX2_23144817_ChIP-Seq_PC3_Human1.31228774
38STAT3_23295773_ChIP-Seq_U87_Human1.31050705
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30373530
40NANOG_20526341_ChIP-Seq_ESCs_Human1.29711215
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28681178
42CTCF_27219007_Chip-Seq_Bcells_Human1.28351187
43P300_19829295_ChIP-Seq_ESCs_Human1.27604246
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.27282704
45TAF2_19829295_ChIP-Seq_ESCs_Human1.27201688
46MYC_19829295_ChIP-Seq_ESCs_Human1.25918993
47EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.25264784
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.24951403
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.22916968
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.22691306
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.22066518
52TAF15_26573619_Chip-Seq_HEK293_Human1.21290651
53OCT4_20526341_ChIP-Seq_ESCs_Human1.21118211
54RUNX2_22187159_ChIP-Seq_PCA_Human1.21075128
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20878562
56RAC3_21632823_ChIP-Seq_H3396_Human1.20158072
57SMRT_27268052_Chip-Seq_Bcells_Human1.19803374
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17995188
59SMAD4_21799915_ChIP-Seq_A2780_Human1.17772104
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.17237549
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16930523
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16563254
63TCF4_23295773_ChIP-Seq_U87_Human1.14724299
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13838330
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13439188
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13045788
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.12466551
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.12106222
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12040672
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11568775
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10573919
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08716455
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08566817
74E2F1_20622854_ChIP-Seq_HELA_Human1.08203032
75BCL6_27268052_Chip-Seq_Bcells_Human1.07696363
76OCT1_27270436_Chip-Seq_PROSTATE_Human1.07170882
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06773060
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04810986
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04094416
80SMC4_20622854_ChIP-Seq_HELA_Human1.02416961
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.01786375
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.00721302
83ETV1_20927104_ChIP-Seq_GIST48_Human1.00271446
84HOXB7_26014856_ChIP-Seq_BT474_Human0.99687632
85TBL1_22424771_ChIP-Seq_293T_Human0.99575305
86BP1_19119308_ChIP-ChIP_Hs578T_Human0.98862885
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98630355
88OCT4_19829295_ChIP-Seq_ESCs_Human0.98170406
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97941908
90TP63_22573176_ChIP-Seq_HFKS_Human0.97395159
91P300_27268052_Chip-Seq_Bcells_Human0.97082603
92AHR_22903824_ChIP-Seq_MCF-7_Human0.96119044
93P53_21459846_ChIP-Seq_SAOS-2_Human0.95813138
94CEBPB_22108803_ChIP-Seq_LS180_Human0.95259729
95PHF8_20622854_ChIP-Seq_HELA_Human0.95223479
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94990133
97RNF2_27304074_Chip-Seq_ESCs_Mouse0.94634936
98NCOR_22424771_ChIP-Seq_293T_Human0.94527295
99RXR_22108803_ChIP-Seq_LS180_Human0.94110633
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93210303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.83795339
2MP0005377_hearing/vestibular/ear_phenot4.39033777
3MP0003878_abnormal_ear_physiology4.39033777
4MP0005670_abnormal_white_adipose3.80517625
5MP0003698_abnormal_male_reproductive3.06929852
6MP0003646_muscle_fatigue2.86197135
7MP0001348_abnormal_lacrimal_gland2.76208974
8MP0001929_abnormal_gametogenesis2.49923749
9MP0000569_abnormal_digit_pigmentation2.30621504
10MP0006292_abnormal_olfactory_placode2.25280127
11MP0001485_abnormal_pinna_reflex2.12718111
12MP0005423_abnormal_somatic_nervous2.00610482
13MP0003787_abnormal_imprinting1.91970753
14MP0003011_delayed_dark_adaptation1.88042663
15MP0002138_abnormal_hepatobiliary_system1.82817638
16MP0005551_abnormal_eye_electrophysiolog1.73896557
17MP0004742_abnormal_vestibular_system1.73581105
18MP0002653_abnormal_ependyma_morphology1.68164771
19MP0001968_abnormal_touch/_nociception1.64537785
20MP0001486_abnormal_startle_reflex1.63270754
21MP0008877_abnormal_DNA_methylation1.59548577
22MP0002161_abnormal_fertility/fecundity1.58175448
23MP0002735_abnormal_chemical_nociception1.53885858
24MP0003879_abnormal_hair_cell1.52786382
25MP0005379_endocrine/exocrine_gland_phen1.49984982
26MP0005310_abnormal_salivary_gland1.44141483
27MP0003136_yellow_coat_color1.35665304
28MP0002249_abnormal_larynx_morphology1.34952451
29MP0001501_abnormal_sleep_pattern1.30161158
30MP0002822_catalepsy1.28544436
31MP0002928_abnormal_bile_duct1.27789005
32MP0002272_abnormal_nervous_system1.25098487
33MP0002210_abnormal_sex_determination1.22375689
34MP0002067_abnormal_sensory_capabilities1.20779198
35MP0009745_abnormal_behavioral_response1.20079579
36MP0001765_abnormal_ion_homeostasis1.18101011
37MP0000026_abnormal_inner_ear1.16055505
38MP0001963_abnormal_hearing_physiology1.11586320
39MP0002557_abnormal_social/conspecific_i1.10879986
40MP0002733_abnormal_thermal_nociception1.10471736
41MP0000678_abnormal_parathyroid_gland1.09893223
42MP0002229_neurodegeneration1.08547089
43MP0000955_abnormal_spinal_cord1.05958678
44MP0009115_abnormal_fat_cell1.05735618
45MP0008961_abnormal_basal_metabolism1.05099889
46MP0002572_abnormal_emotion/affect_behav1.05045902
47MP0001986_abnormal_taste_sensitivity1.04616023
48MP0004142_abnormal_muscle_tone1.04517761
49MP0002132_abnormal_respiratory_system1.04489909
50MP0003718_maternal_effect1.04157274
51MP0003880_abnormal_central_pattern1.02014851
52MP0001440_abnormal_grooming_behavior0.99080531
53MP0005083_abnormal_biliary_tract0.96628728
54MP0005174_abnormal_tail_pigmentation0.96305744
55MP0001145_abnormal_male_reproductive0.94271606
56MP0000653_abnormal_sex_gland0.92823640
57MP0005167_abnormal_blood-brain_barrier0.91739162
58MP0001970_abnormal_pain_threshold0.90259949
59MP0008995_early_reproductive_senescence0.90247709
60MP0005646_abnormal_pituitary_gland0.89798252
61MP0004859_abnormal_synaptic_plasticity0.86623240
62MP0002127_abnormal_cardiovascular_syste0.84994002
63MP0006276_abnormal_autonomic_nervous0.83311311
64MP0004510_myositis0.82097112
65MP0004043_abnormal_pH_regulation0.81589472
66MP0003635_abnormal_synaptic_transmissio0.81522663
67MP0002234_abnormal_pharynx_morphology0.80943651
68MP0001984_abnormal_olfaction0.79390319
69MP0009046_muscle_twitch0.79162413
70MP0000230_abnormal_systemic_arterial0.78646042
71MP0000470_abnormal_stomach_morphology0.77912440
72MP0004130_abnormal_muscle_cell0.76926200
73MP0001905_abnormal_dopamine_level0.75617708
74MP0005253_abnormal_eye_physiology0.75045805
75MP0002064_seizures0.74505953
76MP0002063_abnormal_learning/memory/cond0.74118311
77MP0004885_abnormal_endolymph0.74029077
78MP0001873_stomach_inflammation0.73124858
79MP0005645_abnormal_hypothalamus_physiol0.73109766
80MP0001502_abnormal_circadian_rhythm0.72896319
81MP0000015_abnormal_ear_pigmentation0.71148578
82MP0002752_abnormal_somatic_nervous0.70835444
83MP0000566_synostosis0.69712432
84MP0002638_abnormal_pupillary_reflex0.69077810
85MP0000778_abnormal_nervous_system0.68477179
86MP0001879_abnormal_lymphatic_vessel0.68245020
87MP0002882_abnormal_neuron_morphology0.67654294
88MP0004484_altered_response_of0.67236056
89MP0002876_abnormal_thyroid_physiology0.66740622
90MP0008872_abnormal_physiological_respon0.65702404
91MP0000631_abnormal_neuroendocrine_gland0.65281961
92MP0004085_abnormal_heartbeat0.63297978
93MP0003045_fibrosis0.63197719
94MP0005395_other_phenotype0.62387294
95MP0009764_decreased_sensitivity_to0.61678729
96MP0000049_abnormal_middle_ear0.60661063
97MP0002095_abnormal_skin_pigmentation0.59791873
98MP0002837_dystrophic_cardiac_calcinosis0.59776998
99MP0001800_abnormal_humoral_immune0.59616218
100MP0005195_abnormal_posterior_eye0.58513317

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.71089705
2Chronic hepatic failure (HP:0100626)4.59711488
3Absent/shortened dynein arms (HP:0200106)4.47365132
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.47365132
5Progressive cerebellar ataxia (HP:0002073)4.15809423
6Attenuation of retinal blood vessels (HP:0007843)4.15525226
7Bony spicule pigmentary retinopathy (HP:0007737)4.00137171
8Abnormal rod and cone electroretinograms (HP:0008323)3.83831112
9Nephronophthisis (HP:0000090)3.74318132
10Hyperkalemia (HP:0002153)3.71794819
11Genetic anticipation (HP:0003743)3.63920526
12Abnormality of the renal medulla (HP:0100957)3.48053805
13Tubulointerstitial nephritis (HP:0001970)3.44390637
14Abnormal ciliary motility (HP:0012262)3.44220753
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.34266986
16Abnormal drinking behavior (HP:0030082)3.31189622
17Polydipsia (HP:0001959)3.31189622
18Hypoplastic ischia (HP:0003175)3.30128556
19Abnormal respiratory motile cilium physiology (HP:0012261)3.25402971
20Facial shape deformation (HP:0011334)3.21325598
21Potter facies (HP:0002009)3.21325598
22Abnormal respiratory motile cilium morphology (HP:0005938)3.14833755
23Abnormal respiratory epithelium morphology (HP:0012253)3.14833755
24Tubular atrophy (HP:0000092)3.06372243
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.88914995
26Bell-shaped thorax (HP:0001591)2.88082507
27Pancreatic fibrosis (HP:0100732)2.85195428
28Impulsivity (HP:0100710)2.85075844
29Abnormality of the aortic arch (HP:0012303)2.83415963
30Abnormal urine output (HP:0012590)2.80090648
31Abnormality of the ischium (HP:0003174)2.78012445
32Polyuria (HP:0000103)2.76310916
33Pancreatic cysts (HP:0001737)2.75646525
34Abnormality of midbrain morphology (HP:0002418)2.72870222
35Molar tooth sign on MRI (HP:0002419)2.72870222
36Abnormality of macular pigmentation (HP:0008002)2.72473684
37Truncal obesity (HP:0001956)2.65817849
38Congenital stationary night blindness (HP:0007642)2.55278384
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53542038
40Renal dysplasia (HP:0000110)2.51279104
41Infertility (HP:0000789)2.50822715
42Abnormality of renal excretion (HP:0011036)2.50251773
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.46916211
44Postural instability (HP:0002172)2.44806952
45Cone-rod dystrophy (HP:0000548)2.42155175
46Enlarged epiphyses (HP:0010580)2.37818627
47Abnormality of the renal cortex (HP:0011035)2.35044256
48Abnormality of potassium homeostasis (HP:0011042)2.32088227
49Cystic liver disease (HP:0006706)2.31278177
50Abnormality of the nasal septum (HP:0000419)2.29118628
51Cerebellar dysplasia (HP:0007033)2.27897985
52Tubulointerstitial abnormality (HP:0001969)2.24213041
53Amelogenesis imperfecta (HP:0000705)2.21594115
54Bulbous nose (HP:0000414)2.17910802
55Hypoplasia of the thymus (HP:0000778)2.16242052
56Stage 5 chronic kidney disease (HP:0003774)2.15309382
57Type II lissencephaly (HP:0007260)2.14887797
58True hermaphroditism (HP:0010459)2.13403071
59Abnormality of DNA repair (HP:0003254)2.12817744
60Asymmetric septal hypertrophy (HP:0001670)2.11470834
61Portal hypertension (HP:0001409)2.05451692
62Gaze-evoked nystagmus (HP:0000640)2.04101563
63Abnormality of the parathyroid morphology (HP:0011766)2.02138428
64Decreased central vision (HP:0007663)2.01504951
65Optic nerve hypoplasia (HP:0000609)1.94168752
66Congenital hepatic fibrosis (HP:0002612)1.90942275
67Epiphyseal dysplasia (HP:0002656)1.89673489
68Decreased circulating renin level (HP:0003351)1.89258008
69Azoospermia (HP:0000027)1.88699759
70Abnormality of the pubic bones (HP:0003172)1.88591322
71Abnormality of the hepatic vasculature (HP:0006707)1.85239689
72Febrile seizures (HP:0002373)1.84554488
73Nasal polyposis (HP:0100582)1.83186229
74Abnormality of the fingertips (HP:0001211)1.82280604
75Rhinitis (HP:0012384)1.81404720
76Sclerocornea (HP:0000647)1.80745367
77Macular degeneration (HP:0000608)1.80638321
78Abnormality of chloride homeostasis (HP:0011422)1.80100995
79Abnormality of the epiphysis of the femoral head (HP:0010574)1.79894396
80Atonic seizures (HP:0010819)1.79552530
81Supernumerary bones of the axial skeleton (HP:0009144)1.78759449
82Anencephaly (HP:0002323)1.78294421
83Clumsiness (HP:0002312)1.77907259
84Double outlet right ventricle (HP:0001719)1.74447858
85Congenital malformation of the right heart (HP:0011723)1.74447858
86Bronchiectasis (HP:0002110)1.73918724
87Poor coordination (HP:0002370)1.72881672
88Medial flaring of the eyebrow (HP:0010747)1.72090604
89Pendular nystagmus (HP:0012043)1.71925472
90Abnormality of dental color (HP:0011073)1.70704427
91Abnormal spermatogenesis (HP:0008669)1.69206599
92Hyperventilation (HP:0002883)1.68627564
93Abnormality of the femoral head (HP:0003368)1.68519752
94Hyperthyroidism (HP:0000836)1.67089243
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65735276
96Supernumerary ribs (HP:0005815)1.65360257
97Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.64253302
98Abnormality of femoral epiphyses (HP:0006499)1.64253302
99Resting tremor (HP:0002322)1.63056346
100Stereotypic behavior (HP:0000733)1.61327501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.23214535
2FRK3.71044048
3INSRR3.45547423
4CAMK1G2.83118349
5DDR22.65260272
6MAP4K22.55067244
7MAPK152.50627642
8WNK42.38491063
9CAMK1D2.23046851
10WNK12.22387101
11PNCK2.19083189
12STK382.12232992
13BMPR1B2.11450270
14BRD41.91461482
15AKT31.80890682
16SIK21.54750218
17TESK11.46815003
18PLK21.45954773
19TAOK31.43697868
20CDK121.42619689
21STK38L1.35758346
22ACVR1B1.31771658
23PIK3CG1.31407504
24MARK21.31287924
25SGK2231.27638264
26SGK4941.27638264
27STK391.27556468
28SGK21.23020367
29TXK1.20200904
30CAMK11.18542353
31ADRBK21.16250295
32PRKD31.15568997
33TYRO31.13993930
34PDK11.13180172
35PRKAA21.11068863
36NTRK31.10624488
37PTK2B1.07699370
38BLK1.05098796
39PDPK11.02306074
40PIK3CA1.01614557
41MAP3K71.00223070
42TNK20.97136757
43PINK10.91439989
44NUAK10.91327130
45OXSR10.88474557
46NLK0.84961418
47SGK10.82748026
48MAPK130.82674935
49CAMK40.82424888
50STK110.79682837
51TIE10.79004024
52MAP2K20.78613097
53MAP3K40.77732444
54GRK10.76939248
55DYRK1B0.76570126
56TEC0.74866632
57TLK10.74436004
58CHUK0.73907208
59MARK30.72596115
60RPS6KA60.71328759
61RPS6KA20.70678992
62ZAK0.67851837
63FGFR20.64289244
64MAP3K110.62530785
65NEK60.62406382
66MARK10.60730947
67NTRK20.60487748
68TNIK0.60063059
69IKBKB0.59021622
70SGK30.58488507
71PRKG10.58457819
72SYK0.57754885
73KIT0.57752114
74PRKCG0.56870213
75TRPM70.54694136
76MAP4K10.54382050
77ITK0.54265607
78PRKCH0.54154617
79DAPK20.53821562
80PRKCZ0.53660838
81MTOR0.53473270
82MAPK10.52285868
83MAP2K60.52172177
84GSK3B0.52086702
85PRKCQ0.51864686
86CASK0.51792434
87RPS6KC10.49950956
88RPS6KL10.49950956
89MAPK80.49020492
90PRKAA10.48580391
91RPS6KA10.48407087
92LATS10.48029880
93BTK0.47903119
94CDK30.47901689
95AKT10.47455564
96PAK30.46445136
97MUSK0.45577586
98NEK20.44655399
99MST1R0.43644133
100PKN10.43557696

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.36948463
2Fatty acid biosynthesis_Homo sapiens_hsa000613.28545619
3Olfactory transduction_Homo sapiens_hsa047402.71080573
4Dorso-ventral axis formation_Homo sapiens_hsa043202.11733649
5Phototransduction_Homo sapiens_hsa047442.05358754
6Taste transduction_Homo sapiens_hsa047421.96074671
7Butanoate metabolism_Homo sapiens_hsa006501.91149162
8Linoleic acid metabolism_Homo sapiens_hsa005911.84169901
9Nicotine addiction_Homo sapiens_hsa050331.79173767
10Graft-versus-host disease_Homo sapiens_hsa053321.78880157
11Allograft rejection_Homo sapiens_hsa053301.70542552
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65540230
13Autoimmune thyroid disease_Homo sapiens_hsa053201.64283322
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64217865
15Glycerophospholipid metabolism_Homo sapiens_hsa005641.57697675
16Morphine addiction_Homo sapiens_hsa050321.49869139
17Type I diabetes mellitus_Homo sapiens_hsa049401.49128859
18ABC transporters_Homo sapiens_hsa020101.48549625
19Type II diabetes mellitus_Homo sapiens_hsa049301.39290098
20Insulin secretion_Homo sapiens_hsa049111.33685160
21Nitrogen metabolism_Homo sapiens_hsa009101.30388426
22Salivary secretion_Homo sapiens_hsa049701.23594752
23Glutamatergic synapse_Homo sapiens_hsa047241.22752057
24Calcium signaling pathway_Homo sapiens_hsa040201.18806373
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.18292804
26Circadian entrainment_Homo sapiens_hsa047131.16424966
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13783638
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.12508694
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10422548
30cAMP signaling pathway_Homo sapiens_hsa040241.06019212
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02324874
32Cholinergic synapse_Homo sapiens_hsa047250.99362684
33Lysine degradation_Homo sapiens_hsa003100.97472138
34Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95574762
35Serotonergic synapse_Homo sapiens_hsa047260.93848810
36Antigen processing and presentation_Homo sapiens_hsa046120.93336665
37Ether lipid metabolism_Homo sapiens_hsa005650.92076801
38MAPK signaling pathway_Homo sapiens_hsa040100.91955146
39Glycerolipid metabolism_Homo sapiens_hsa005610.90693122
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.90498910
41Primary immunodeficiency_Homo sapiens_hsa053400.88563157
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.87041531
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86591954
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86024835
45Oxytocin signaling pathway_Homo sapiens_hsa049210.84229063
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83620344
47Gastric acid secretion_Homo sapiens_hsa049710.79745921
48Caffeine metabolism_Homo sapiens_hsa002320.79421212
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77822528
50Cardiac muscle contraction_Homo sapiens_hsa042600.77427745
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76413368
52Renin secretion_Homo sapiens_hsa049240.74426883
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.73172452
54GABAergic synapse_Homo sapiens_hsa047270.72811752
55Notch signaling pathway_Homo sapiens_hsa043300.70701929
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70532161
57Inositol phosphate metabolism_Homo sapiens_hsa005620.70095070
58Retinol metabolism_Homo sapiens_hsa008300.68699528
59T cell receptor signaling pathway_Homo sapiens_hsa046600.67920187
60Fatty acid degradation_Homo sapiens_hsa000710.67684934
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65397371
62Fanconi anemia pathway_Homo sapiens_hsa034600.65136556
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64402382
64B cell receptor signaling pathway_Homo sapiens_hsa046620.64175535
65Asthma_Homo sapiens_hsa053100.61047209
66Ovarian steroidogenesis_Homo sapiens_hsa049130.60942775
67Hedgehog signaling pathway_Homo sapiens_hsa043400.60734268
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60382537
69Bile secretion_Homo sapiens_hsa049760.57989843
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57988015
71Tryptophan metabolism_Homo sapiens_hsa003800.57258131
72Pancreatic secretion_Homo sapiens_hsa049720.56510493
73Estrogen signaling pathway_Homo sapiens_hsa049150.56390887
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.54790920
75Long-term depression_Homo sapiens_hsa047300.53370285
76Circadian rhythm_Homo sapiens_hsa047100.52567274
77VEGF signaling pathway_Homo sapiens_hsa043700.52403788
78Choline metabolism in cancer_Homo sapiens_hsa052310.51883897
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51143518
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50888908
81FoxO signaling pathway_Homo sapiens_hsa040680.49892097
82Fat digestion and absorption_Homo sapiens_hsa049750.49761277
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49579400
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48579636
85Cocaine addiction_Homo sapiens_hsa050300.47810658
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47654287
87Amphetamine addiction_Homo sapiens_hsa050310.47080660
88Viral myocarditis_Homo sapiens_hsa054160.47063420
89Arachidonic acid metabolism_Homo sapiens_hsa005900.46261344
90Influenza A_Homo sapiens_hsa051640.46161768
91Insulin resistance_Homo sapiens_hsa049310.45171109
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44923213
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.44816151
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44207151
95Protein digestion and absorption_Homo sapiens_hsa049740.44179750
96Dopaminergic synapse_Homo sapiens_hsa047280.42114482
97Regulation of autophagy_Homo sapiens_hsa041400.40670770
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40309360
99Basal transcription factors_Homo sapiens_hsa030220.39644082
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37671387

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