NPIPB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of ARF GTPase activity (GO:0032312)4.81248778
2negative regulation of myotube differentiation (GO:0010832)4.65318187
3histone H3-K4 trimethylation (GO:0080182)4.47706442
4establishment of protein localization to Golgi (GO:0072600)4.43233463
5positive regulation of gamma-delta T cell activation (GO:0046645)4.33118544
6retrograde transport, vesicle recycling within Golgi (GO:0000301)4.24773201
7protein targeting to Golgi (GO:0000042)4.17827902
8positive regulation of granulocyte differentiation (GO:0030854)4.14579980
9regulation of gamma-delta T cell differentiation (GO:0045586)3.92941906
10regulation of gamma-delta T cell activation (GO:0046643)3.90759544
11maintenance of gastrointestinal epithelium (GO:0030277)3.86778215
12histone H3-K36 demethylation (GO:0070544)3.74750121
13negative thymic T cell selection (GO:0045060)3.68878773
14mannose metabolic process (GO:0006013)3.63844996
15thymic T cell selection (GO:0045061)3.55672037
16negative T cell selection (GO:0043383)3.55539311
17histone H3-K4 methylation (GO:0051568)3.51766145
18histone H3-K9 demethylation (GO:0033169)3.47701397
19positive regulation of histone deacetylation (GO:0031065)3.39612206
20regulation of histone H3-K27 methylation (GO:0061085)3.39242280
21histone H3-K9 modification (GO:0061647)3.37678789
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37456648
23striated muscle atrophy (GO:0014891)3.29328634
24regulation of granulocyte differentiation (GO:0030852)3.28582821
25regulation of B cell receptor signaling pathway (GO:0050855)3.25129356
26T cell selection (GO:0045058)3.24275235
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24173076
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23960897
29negative regulation of cell killing (GO:0031342)3.23354991
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23354991
31response to muramyl dipeptide (GO:0032495)3.22118676
32positive thymic T cell selection (GO:0045059)3.21548334
33regulation of ARF protein signal transduction (GO:0032012)3.19847583
34positive regulation of CREB transcription factor activity (GO:0032793)3.17178112
35antigen processing and presentation of endogenous antigen (GO:0019883)3.11590220
36peptidyl-lysine trimethylation (GO:0018023)3.10091896
37positive T cell selection (GO:0043368)3.06600525
38protein localization to Golgi apparatus (GO:0034067)3.06463209
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.00362274
40skeletal muscle adaptation (GO:0043501)2.99973651
41germinal center formation (GO:0002467)2.99898350
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99705915
43histone lysine demethylation (GO:0070076)2.99087017
44histone lysine methylation (GO:0034968)2.98884991
45positive regulation of protein deacetylation (GO:0090312)2.98720287
46epithelial structure maintenance (GO:0010669)2.98238034
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.95033209
48histone H3-K9 methylation (GO:0051567)2.94141407
49histone demethylation (GO:0016577)2.91138861
50regulation of MHC class I biosynthetic process (GO:0045343)2.89283369
51dendritic cell chemotaxis (GO:0002407)2.87047724
52B cell receptor signaling pathway (GO:0050853)2.87038057
53muscle atrophy (GO:0014889)2.82199065
54positive regulation of Rap GTPase activity (GO:0032854)2.81839791
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81419802
56positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79901583
57negative regulation of cAMP-mediated signaling (GO:0043951)2.74118349
58negative regulation of erythrocyte differentiation (GO:0045647)2.68597130
59peptidyl-lysine methylation (GO:0018022)2.68094918
60negative regulation of granulocyte differentiation (GO:0030853)2.67566871
61monoubiquitinated protein deubiquitination (GO:0035520)2.62519138
62regulation of podosome assembly (GO:0071801)2.58977477
63O-glycan processing (GO:0016266)2.52340395
64auditory receptor cell differentiation (GO:0042491)2.51300990
65cellular extravasation (GO:0045123)2.48033356
66response to interleukin-15 (GO:0070672)2.48025161
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47590849
68protein demethylation (GO:0006482)2.45863822
69protein dealkylation (GO:0008214)2.45863822
70activated T cell proliferation (GO:0050798)2.40974562
71interkinetic nuclear migration (GO:0022027)2.39563987
72regulation of histone deacetylation (GO:0031063)2.38347750
73nephron tubule morphogenesis (GO:0072078)2.38329483
74nephron epithelium morphogenesis (GO:0072088)2.38329483
75positive regulation of B cell differentiation (GO:0045579)2.36759019
76negative regulation of histone methylation (GO:0031061)2.36536646
77negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35841545
78definitive hemopoiesis (GO:0060216)2.35216456
79regulation of necroptotic process (GO:0060544)2.33947420
80N-terminal protein amino acid acetylation (GO:0006474)2.33465413
81positive regulation of Rho GTPase activity (GO:0032321)2.32479398
82dendritic cell migration (GO:0036336)2.32350220
83cellular response to ethanol (GO:0071361)2.31614469
84regulation of cholesterol homeostasis (GO:2000188)2.31543341
85cellular response to epidermal growth factor stimulus (GO:0071364)2.31191348
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.30821310
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28922760
88activation of JUN kinase activity (GO:0007257)2.28729467
89regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27773841
90regulation of B cell differentiation (GO:0045577)2.27323151
91histone deubiquitination (GO:0016578)2.27046869
92negative regulation of T-helper cell differentiation (GO:0045623)2.26957050
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.26957050
94Golgi to endosome transport (GO:0006895)2.26079400
95cytoplasmic mRNA processing body assembly (GO:0033962)2.25556373
96regulation of Rap GTPase activity (GO:0032317)2.24749236
97detection of bacterium (GO:0016045)2.24403885
98positive regulation of Ras GTPase activity (GO:0032320)2.23291185
99receptor catabolic process (GO:0032801)2.23065064
100regulation of Ras GTPase activity (GO:0032318)2.22641073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.76041654
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24553397
3DROSHA_22980978_ChIP-Seq_HELA_Human3.13784184
4VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.88010391
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.46678349
6SCL_19346495_ChIP-Seq_HPC-7_Human2.41987537
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38984853
8RUNX_20019798_ChIP-Seq_JUKART_Human2.37047170
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30911838
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22948154
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22407280
12MYC_22102868_ChIP-Seq_BL_Human2.22175161
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10054160
14TCF7_22412390_ChIP-Seq_EML_Mouse2.09785959
15SPI1_23127762_ChIP-Seq_K562_Human2.06972304
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96134623
17VDR_21846776_ChIP-Seq_THP-1_Human1.94984016
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93390993
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87855306
20KDM2B_26808549_Chip-Seq_DND41_Human1.87138566
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84981082
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84408771
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82632431
24GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73914103
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.73696535
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.71263210
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61202132
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60802435
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.60241965
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56678199
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.55900316
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55539895
33MYB_26560356_Chip-Seq_TH2_Human1.53100776
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.52768151
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.52355437
36MAF_26560356_Chip-Seq_TH1_Human1.49731385
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49704012
38VDR_24763502_ChIP-Seq_THP-1_Human1.49560903
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.48624614
40UTX_26944678_Chip-Seq_JUKART_Human1.48575879
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48254000
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48082326
43MAF_26560356_Chip-Seq_TH2_Human1.45180242
44LXR_22292898_ChIP-Seq_THP-1_Human1.45052810
45SMC4_20622854_ChIP-Seq_HELA_Human1.43997088
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42528123
47MYB_26560356_Chip-Seq_TH1_Human1.41772554
48KDM2B_26808549_Chip-Seq_K562_Human1.41689724
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.41468336
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37824841
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36913512
52GATA3_27048872_Chip-Seq_THYMUS_Human1.36668815
53AR_21572438_ChIP-Seq_LNCaP_Human1.34485533
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34464724
55GATA1_19941826_ChIP-Seq_K562_Human1.33795234
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.33148200
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.31970161
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30125407
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27672142
60OCT4_19829295_ChIP-Seq_ESCs_Human1.27533727
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.27093770
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.25462379
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.24563523
64GATA1_22025678_ChIP-Seq_K562_Human1.20392463
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16828280
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12078137
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09583447
68TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07439734
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.06085118
70P68_20966046_ChIP-Seq_HELA_Human1.05680121
71TP63_22573176_ChIP-Seq_HFKS_Human1.05637756
72VDR_24787735_ChIP-Seq_THP-1_Human1.05041711
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03171819
74GATA2_19941826_ChIP-Seq_K562_Human1.01087661
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00693134
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00469653
77NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99330295
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99105317
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99079325
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.98971255
81CIITA_25753668_ChIP-Seq_RAJI_Human0.96858892
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96385337
83SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95898367
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95643555
85TP53_16413492_ChIP-PET_HCT116_Human0.94533024
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.94502839
87CREB1_26743006_Chip-Seq_LNCaP_Human0.94089287
88RACK7_27058665_Chip-Seq_MCF-7_Human0.93216186
89AHR_22903824_ChIP-Seq_MCF-7_Human0.91920020
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.91742034
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91694181
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91589476
93BCOR_27268052_Chip-Seq_Bcells_Human0.91344657
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91186077
95KLF5_25053715_ChIP-Seq_YYC3_Human0.90990833
96BCL6_27268052_Chip-Seq_Bcells_Human0.90819092
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89898498
98BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89734612
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88496198
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87748833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.36686731
2MP0003172_abnormal_lysosome_physiology2.93556399
3MP0003045_fibrosis2.92865903
4MP0003183_abnormal_peptide_metabolism2.63558125
5MP0003866_abnormal_defecation2.58036977
6MP0001835_abnormal_antigen_presentation2.55897547
7MP0009278_abnormal_bone_marrow2.55634681
8MP0001800_abnormal_humoral_immune2.43867982
9MP0005076_abnormal_cell_differentiation2.43618922
10MP0003436_decreased_susceptibility_to2.42916661
11MP0002396_abnormal_hematopoietic_system2.24367079
12MP0005670_abnormal_white_adipose2.13752230
13MP0004381_abnormal_hair_follicle2.10496789
14MP0005387_immune_system_phenotype2.05626558
15MP0001790_abnormal_immune_system2.05626558
16MP0000685_abnormal_immune_system2.01930812
17MP0010155_abnormal_intestine_physiology1.99828721
18MP0004043_abnormal_pH_regulation1.97852995
19MP0005310_abnormal_salivary_gland1.87674591
20MP0003303_peritoneal_inflammation1.81994967
21MP0008057_abnormal_DNA_replication1.80409180
22MP0002138_abnormal_hepatobiliary_system1.79444034
23MP0005409_darkened_coat_color1.78543974
24MP0001873_stomach_inflammation1.73851452
25MP0002723_abnormal_immune_serum1.73845330
26MP0002398_abnormal_bone_marrow1.71639710
27MP0002420_abnormal_adaptive_immunity1.70767265
28MP0003300_gastrointestinal_ulcer1.69885926
29MP0005671_abnormal_response_to1.68649481
30MP0001819_abnormal_immune_cell1.68297026
31MP0005025_abnormal_response_to1.68102214
32MP0005000_abnormal_immune_tolerance1.67085212
33MP0003879_abnormal_hair_cell1.66867930
34MP0002452_abnormal_antigen_presenting1.66289953
35MP0001545_abnormal_hematopoietic_system1.59818364
36MP0005397_hematopoietic_system_phenotyp1.59818364
37MP0001348_abnormal_lacrimal_gland1.59486048
38MP0000703_abnormal_thymus_morphology1.57727319
39MP0004264_abnormal_extraembryonic_tissu1.53797318
40MP0002405_respiratory_system_inflammati1.50317092
41MP0002419_abnormal_innate_immunity1.48461120
42MP0000716_abnormal_immune_system1.46658715
43MP0008004_abnormal_stomach_pH1.40648280
44MP0004947_skin_inflammation1.40021755
45MP0003279_aneurysm1.38858858
46MP0001501_abnormal_sleep_pattern1.36892428
47MP0005058_abnormal_lysosome_morphology1.30438306
48MP0002822_catalepsy1.28624925
49MP0004808_abnormal_hematopoietic_stem1.25442289
50MP0002722_abnormal_immune_system1.21878113
51MP0001851_eye_inflammation1.20843265
52MP0000465_gastrointestinal_hemorrhage1.20729055
53MP0009115_abnormal_fat_cell1.20185881
54MP0002933_joint_inflammation1.20138887
55MP0003724_increased_susceptibility_to1.18731779
56MP0001663_abnormal_digestive_system1.18355222
57MP0003091_abnormal_cell_migration1.18017506
58MP0005377_hearing/vestibular/ear_phenot1.16918637
59MP0003878_abnormal_ear_physiology1.16918637
60MP0002168_other_aberrant_phenotype1.16764220
61MP0002166_altered_tumor_susceptibility1.16233480
62MP0000689_abnormal_spleen_morphology1.14342833
63MP0002429_abnormal_blood_cell1.12330095
64MP0001270_distended_abdomen1.11925473
65MP0001765_abnormal_ion_homeostasis1.11323017
66MP0005083_abnormal_biliary_tract1.06615167
67MP0008961_abnormal_basal_metabolism1.05994315
68MP0002132_abnormal_respiratory_system1.05294141
69MP0002970_abnormal_white_adipose1.00836498
70MP0009785_altered_susceptibility_to1.00254439
71MP0003943_abnormal_hepatobiliary_system0.99622004
72MP0002998_abnormal_bone_remodeling0.98289440
73MP0005666_abnormal_adipose_tissue0.96215709
74MP0003252_abnormal_bile_duct0.95981428
75MP0002249_abnormal_larynx_morphology0.94527603
76MP0003787_abnormal_imprinting0.93845364
77MP0003705_abnormal_hypodermis_morpholog0.93125466
78MP0004036_abnormal_muscle_relaxation0.91823094
79MP0000569_abnormal_digit_pigmentation0.90607365
80MP0005381_digestive/alimentary_phenotyp0.89444372
81MP0003646_muscle_fatigue0.87116235
82MP0002254_reproductive_system_inflammat0.87025835
83MP0005375_adipose_tissue_phenotype0.86472881
84MP0001666_abnormal_nutrient_absorption0.84569867
85MP0001845_abnormal_inflammatory_respons0.83922889
86MP0005448_abnormal_energy_balance0.81459881
87MP0004130_abnormal_muscle_cell0.81188917
88MP0002009_preneoplasia0.79931316
89MP0005360_urolithiasis0.78586151
90MP0001664_abnormal_digestion0.78250908
91MP0005464_abnormal_platelet_physiology0.77725537
92MP0001502_abnormal_circadian_rhythm0.77089860
93MP0001485_abnormal_pinna_reflex0.77044799
94MP0000470_abnormal_stomach_morphology0.76238718
95MP0009333_abnormal_splenocyte_physiolog0.74798060
96MP0002971_abnormal_brown_adipose0.74695739
97MP0008260_abnormal_autophagy0.74195299
98MP0010630_abnormal_cardiac_muscle0.72542889
99MP0004084_abnormal_cardiac_muscle0.72243836
100MP0002148_abnormal_hypersensitivity_rea0.71942866

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)6.35637595
2Colitis (HP:0002583)4.03798470
3Obstructive sleep apnea (HP:0002870)3.67584488
4Hyperkalemia (HP:0002153)3.27602878
5Inflammation of the large intestine (HP:0002037)3.20224840
6Gastrointestinal inflammation (HP:0004386)3.18798385
7Genetic anticipation (HP:0003743)3.18141631
8Cerebral aneurysm (HP:0004944)3.08735479
9Heterotopia (HP:0002282)3.05026807
10Broad face (HP:0000283)3.00098070
11Long eyelashes (HP:0000527)2.97508730
12Autoimmune hemolytic anemia (HP:0001890)2.91571892
13Narrow palate (HP:0000189)2.79943888
14Abnormality of the columella (HP:0009929)2.72492586
15Abnormality of the nasal septum (HP:0000419)2.69285129
16Myositis (HP:0100614)2.64523935
17Abnormality of chloride homeostasis (HP:0011422)2.63704619
18Abnormal delayed hypersensitivity skin test (HP:0002963)2.62862615
19Ileus (HP:0002595)2.54266225
20Retrobulbar optic neuritis (HP:0100654)2.51290246
21Optic neuritis (HP:0100653)2.51290246
22Malnutrition (HP:0004395)2.49680902
23Chronic diarrhea (HP:0002028)2.45345028
24Orchitis (HP:0100796)2.42969738
25Panhypogammaglobulinemia (HP:0003139)2.42776810
26Abnormality of the aortic arch (HP:0012303)2.41957487
27Prolonged bleeding time (HP:0003010)2.40812865
28Pustule (HP:0200039)2.39225030
29Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.33214854
30Truncal obesity (HP:0001956)2.33036030
31Abnormality of incisor morphology (HP:0011063)2.32902806
32Hemorrhage of the eye (HP:0011885)2.27521270
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27167673
34Recurrent fungal infections (HP:0002841)2.21554751
35Emphysema (HP:0002097)2.21224999
36Vasculitis (HP:0002633)2.18573597
37Gastrointestinal stroma tumor (HP:0100723)2.17009815
38Dislocated radial head (HP:0003083)2.09894383
39Upper limb amyotrophy (HP:0009129)2.09314433
40Distal upper limb amyotrophy (HP:0007149)2.09314433
41Macroorchidism (HP:0000053)2.09295069
42Gingivitis (HP:0000230)2.06276786
43Aneurysm (HP:0002617)2.05630176
44Eczematoid dermatitis (HP:0000976)2.05559374
45Increased IgE level (HP:0003212)2.04074390
46Oligodontia (HP:0000677)2.01783937
47Hypoplastic ischia (HP:0003175)2.01530759
48Recurrent cutaneous fungal infections (HP:0011370)1.98710988
49Chronic mucocutaneous candidiasis (HP:0002728)1.98710988
50Hypoplastic iliac wings (HP:0002866)1.97989033
51Impulsivity (HP:0100710)1.97514578
52Progressive cerebellar ataxia (HP:0002073)1.96150605
53Agammaglobulinemia (HP:0004432)1.95962614
54Spondylolisthesis (HP:0003302)1.93512483
55Gastrointestinal infarctions (HP:0005244)1.90105963
56Prominent nose (HP:0000448)1.89280716
57Abnormality of the radial head (HP:0003995)1.87218172
58Slow saccadic eye movements (HP:0000514)1.86817031
59Supernumerary ribs (HP:0005815)1.85814050
60Aortic aneurysm (HP:0004942)1.85581599
61Urethral obstruction (HP:0000796)1.85009932
62Villous atrophy (HP:0011473)1.84621833
63Abnormality of small intestinal villus morphology (HP:0011472)1.84621833
64Hemoptysis (HP:0002105)1.84072038
65Hyperactive renin-angiotensin system (HP:0000841)1.83742291
66Pulmonary infiltrates (HP:0002113)1.83569449
67Keratoconjunctivitis sicca (HP:0001097)1.81396626
68Neoplasm of the heart (HP:0100544)1.79703491
69Thin bony cortex (HP:0002753)1.79283124
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79113456
71IgM deficiency (HP:0002850)1.76432771
72Supernumerary bones of the axial skeleton (HP:0009144)1.76266321
73Abnormality of the peritoneum (HP:0002585)1.75812709
74Keratoconjunctivitis (HP:0001096)1.75424050
75Broad palm (HP:0001169)1.74673756
76Meningitis (HP:0001287)1.74589859
77Flared iliac wings (HP:0002869)1.73786919
78Onion bulb formation (HP:0003383)1.72462088
79J-shaped sella turcica (HP:0002680)1.71378650
80Peritonitis (HP:0002586)1.70144852
81Mask-like facies (HP:0000298)1.69709125
82Papilledema (HP:0001085)1.65824076
83Clumsiness (HP:0002312)1.65492568
84Autoimmune thrombocytopenia (HP:0001973)1.65469986
85Abnormal hair whorl (HP:0010721)1.64761585
86Granulocytopenia (HP:0001913)1.63993865
87Mitral valve prolapse (HP:0001634)1.62158395
88Lymphopenia (HP:0001888)1.61458680
89Premature skin wrinkling (HP:0100678)1.60564371
90Self-mutilation (HP:0000742)1.60400042
91Recurrent viral infections (HP:0004429)1.59895011
92Elevated erythrocyte sedimentation rate (HP:0003565)1.58382602
93Stomach cancer (HP:0012126)1.57995748
94Abnormality of the sella turcica (HP:0002679)1.57898215
95IgA deficiency (HP:0002720)1.57754987
96Restrictive lung disease (HP:0002091)1.57672976
97Bilateral sensorineural hearing impairment (HP:0008619)1.57038253
98Decreased circulating renin level (HP:0003351)1.56788941
99Laryngomalacia (HP:0001601)1.56276335
100Neonatal hypoglycemia (HP:0001998)1.55726865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.15047876
2WNK43.29213176
3MST1R2.74900316
4MAP4K12.60775212
5BLK2.24855504
6TRIB32.21504547
7ERN12.13982203
8WNK12.11194386
9RIPK42.10563071
10SIK22.02281415
11FGFR42.00119044
12TNK21.99437649
13MAP3K131.98689661
14CDC42BPA1.78200467
15MARK21.77940665
16MAP3K71.74119913
17CAMK1D1.68615365
18CAMK1G1.51273017
19TYK21.45982280
20MET1.44880080
21FRK1.38979816
22FGFR31.37024525
23SIK11.35703418
24BRD41.35612163
25RIPK11.32730419
26NLK1.31493951
27ZAP701.29028635
28ICK1.27575808
29NME11.26631494
30TAOK31.24004227
31LMTK21.23200962
32TXK1.20602515
33TYRO31.15006749
34FES1.10731968
35MAP3K141.10718343
36STK391.10147024
37BTK1.09496076
38MTOR1.09219838
39MAP2K61.02446657
40MAPK111.01036823
41TEC1.00632412
42JAK11.00301363
43ITK1.00230173
44ERBB20.98500179
45SYK0.96977099
46MAP2K30.93905981
47PRPF4B0.92405290
48PRKAA20.92085519
49TRPM70.87890057
50IKBKE0.87359971
51PRKD20.87043400
52KIT0.86552928
53CHUK0.85770042
54PRKCH0.83713529
55FGFR20.83585686
56STK380.82935385
57JAK30.82278636
58HIPK20.80616427
59HCK0.80603079
60PDK10.80518577
61MARK30.79585205
62CSF1R0.79125594
63SGK10.77664606
64LCK0.74305445
65PDGFRB0.73551591
66TBK10.71249678
67PDPK10.70772781
68PKN20.66369329
69PIK3CA0.65509999
70CAMK40.64448530
71MAP3K60.63352583
72GRK60.62397770
73EEF2K0.61979968
74MAPK70.61972318
75SIK30.61778638
76AKT30.61547425
77SGK20.59892782
78EPHB10.59207687
79IKBKB0.58104005
80MELK0.57856182
81CAMKK10.55539935
82MAPK150.53557742
83RPS6KC10.53444557
84RPS6KL10.53444557
85RET0.53327038
86OXSR10.52605117
87PRKAA10.52255231
88MAPK10.51708133
89ACVR1B0.51678093
90SGK30.51600567
91RPS6KA60.51462816
92MAP3K10.50146703
93CAMK10.49940102
94CSK0.49494584
95NEK60.48615273
96MAPK30.48335745
97LYN0.48192625
98TAOK10.47481429
99MAPK120.46575372
100PTK2B0.46179988

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.86065879
2Primary immunodeficiency_Homo sapiens_hsa053401.85429558
3Other glycan degradation_Homo sapiens_hsa005111.82241093
4Notch signaling pathway_Homo sapiens_hsa043301.78416276
5Lysine degradation_Homo sapiens_hsa003101.71805913
6Acute myeloid leukemia_Homo sapiens_hsa052211.67737057
7Dorso-ventral axis formation_Homo sapiens_hsa043201.64899455
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62227789
9Staphylococcus aureus infection_Homo sapiens_hsa051501.61899466
10T cell receptor signaling pathway_Homo sapiens_hsa046601.61793225
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54585503
12Osteoclast differentiation_Homo sapiens_hsa043801.49309536
13ABC transporters_Homo sapiens_hsa020101.47222312
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.45787611
15Graft-versus-host disease_Homo sapiens_hsa053321.44912382
16Allograft rejection_Homo sapiens_hsa053301.43540600
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42460939
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41824611
19Leishmaniasis_Homo sapiens_hsa051401.37968597
20Autoimmune thyroid disease_Homo sapiens_hsa053201.34237399
21Choline metabolism in cancer_Homo sapiens_hsa052311.31759209
22Phospholipase D signaling pathway_Homo sapiens_hsa040721.25072950
23Inositol phosphate metabolism_Homo sapiens_hsa005621.23038805
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19018044
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.18705783
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16770208
27Platelet activation_Homo sapiens_hsa046111.15469859
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15324287
29VEGF signaling pathway_Homo sapiens_hsa043701.13265534
30Long-term potentiation_Homo sapiens_hsa047201.13114623
31GnRH signaling pathway_Homo sapiens_hsa049121.10134902
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09733382
33TNF signaling pathway_Homo sapiens_hsa046681.07193302
34Influenza A_Homo sapiens_hsa051641.06765252
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.06467244
36Toxoplasmosis_Homo sapiens_hsa051451.04320888
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03677314
38African trypanosomiasis_Homo sapiens_hsa051431.02595299
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01943864
40Insulin resistance_Homo sapiens_hsa049311.01437646
41Asthma_Homo sapiens_hsa053101.01433099
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00751761
43Herpes simplex infection_Homo sapiens_hsa051680.99539168
44Type I diabetes mellitus_Homo sapiens_hsa049400.98871475
45Chronic myeloid leukemia_Homo sapiens_hsa052200.98852610
46Non-small cell lung cancer_Homo sapiens_hsa052230.96969175
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96925735
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.96676130
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.95655742
50mTOR signaling pathway_Homo sapiens_hsa041500.94778844
51Measles_Homo sapiens_hsa051620.94247492
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89523082
53Salivary secretion_Homo sapiens_hsa049700.89047666
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88920762
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88864052
56ErbB signaling pathway_Homo sapiens_hsa040120.88623616
57Type II diabetes mellitus_Homo sapiens_hsa049300.88137685
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86976856
59Tuberculosis_Homo sapiens_hsa051520.86782377
60Estrogen signaling pathway_Homo sapiens_hsa049150.83304582
61Hematopoietic cell lineage_Homo sapiens_hsa046400.81686739
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.80800555
63Endometrial cancer_Homo sapiens_hsa052130.79812296
64FoxO signaling pathway_Homo sapiens_hsa040680.78918904
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.78869704
66Renal cell carcinoma_Homo sapiens_hsa052110.77791889
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76632176
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75525611
69Hepatitis C_Homo sapiens_hsa051600.73777646
70Chemokine signaling pathway_Homo sapiens_hsa040620.73280621
71Glucagon signaling pathway_Homo sapiens_hsa049220.72700531
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72228118
73Prolactin signaling pathway_Homo sapiens_hsa049170.71964906
74Hepatitis B_Homo sapiens_hsa051610.70846060
75Malaria_Homo sapiens_hsa051440.70285085
76Gastric acid secretion_Homo sapiens_hsa049710.70098627
77Pancreatic secretion_Homo sapiens_hsa049720.69941945
78Prostate cancer_Homo sapiens_hsa052150.69511096
79Pancreatic cancer_Homo sapiens_hsa052120.68964807
80Antigen processing and presentation_Homo sapiens_hsa046120.67389730
81Renin secretion_Homo sapiens_hsa049240.65869054
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.65533783
83MAPK signaling pathway_Homo sapiens_hsa040100.65422692
84Calcium signaling pathway_Homo sapiens_hsa040200.63853152
85Viral myocarditis_Homo sapiens_hsa054160.62708230
86Adherens junction_Homo sapiens_hsa045200.62619677
87Insulin signaling pathway_Homo sapiens_hsa049100.61988481
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.61347231
89Insulin secretion_Homo sapiens_hsa049110.60986267
90Oxytocin signaling pathway_Homo sapiens_hsa049210.60956466
91Glycerolipid metabolism_Homo sapiens_hsa005610.60930285
92cAMP signaling pathway_Homo sapiens_hsa040240.60228616
93Amoebiasis_Homo sapiens_hsa051460.59319792
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59303975
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59047783
96Cholinergic synapse_Homo sapiens_hsa047250.58526629
97Thyroid hormone synthesis_Homo sapiens_hsa049180.55195812
98Complement and coagulation cascades_Homo sapiens_hsa046100.53649734
99Colorectal cancer_Homo sapiens_hsa052100.53391839
100HIF-1 signaling pathway_Homo sapiens_hsa040660.53111299

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