ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.86483321
2	chromosome condensation (GO:0030261)	8.45165478
3	single strand break repair (GO:0000012)	8.40285920
4	DNA packaging (GO:0006323)	8.11471215
5	sperm capacitation (GO:0048240)	8.02687731
6	microtubule depolymerization (GO:0007019)	7.72873528
7	plasma membrane fusion (GO:0045026)	7.66277681
8	spermatid nucleus differentiation (GO:0007289)	7.56422918
9	spermatid development (GO:0007286)	7.53388939
10	sperm-egg recognition (GO:0035036)	7.17594368
11	protein polyglutamylation (GO:0018095)	6.86775790
12	protein targeting to Golgi (GO:0000042)	6.78937452
13	multicellular organism reproduction (GO:0032504)	6.76210320
14	establishment of protein localization to Golgi (GO:0072600)	6.59752411
15	binding of sperm to zona pellucida (GO:0007339)	6.57781811
16	microtubule polymerization or depolymerization (GO:0031109)	6.43472166
17	calcium ion-dependent exocytosis (GO:0017156)	6.42088757
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.37711904
19	reproduction (GO:0000003)	6.33579326
20	axonemal dynein complex assembly (GO:0070286)	6.32534985
21	rRNA methylation (GO:0031167)	6.28352239
22	sexual reproduction (GO:0019953)	6.02138298
23	cell-cell recognition (GO:0009988)	5.94623799
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.82082056
25	spermatogenesis (GO:0007283)	5.68372620
26	male gamete generation (GO:0048232)	5.66840719
27	centriole replication (GO:0007099)	5.59555455
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.44575392
29	negative regulation of inclusion body assembly (GO:0090084)	5.33291337
30	regulation of cilium movement (GO:0003352)	5.29973399
31	rRNA modification (GO:0000154)	5.26093036
32	cellular ketone body metabolic process (GO:0046950)	5.20542351
33	gamete generation (GO:0007276)	5.20259307
34	microtubule severing (GO:0051013)	5.20165792
35	protein localization to Golgi apparatus (GO:0034067)	5.06146684
36	motile cilium assembly (GO:0044458)	4.93344017
37	cilium or flagellum-dependent cell motility (GO:0001539)	4.84327245
38	regulation of Rab GTPase activity (GO:0032313)	4.84208462
39	positive regulation of Rab GTPase activity (GO:0032851)	4.84208462
40	epithelial cilium movement (GO:0003351)	4.74456795
41	centriole assembly (GO:0098534)	4.68143374
42	single fertilization (GO:0007338)	4.64634587
43	ketone body metabolic process (GO:1902224)	4.58180363
44	seminiferous tubule development (GO:0072520)	4.54586819
45	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.52902369
46	chromatin silencing (GO:0006342)	4.36879300
47	germ cell development (GO:0007281)	4.24360196
48	regulation of centriole replication (GO:0046599)	4.15892137
49	coenzyme catabolic process (GO:0009109)	4.13675159
50	cell wall macromolecule catabolic process (GO:0016998)	4.13674781
51	multicellular organismal reproductive process (GO:0048609)	4.11512868
52	cilium movement (GO:0003341)	4.07139783
53	regulation of transcription involved in cell fate commitment (GO:0060850)	4.05392676
54	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.04142618
55	RNA destabilization (GO:0050779)	4.00959768
56	cell wall macromolecule metabolic process (GO:0044036)	3.92851308
57	regulation of inclusion body assembly (GO:0090083)	3.83163514
58	fertilization (GO:0009566)	3.81115554
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73800302
60	regulation of microtubule-based movement (GO:0060632)	3.73079505
61	nucleus organization (GO:0006997)	3.56638325
62	negative regulation of Rho protein signal transduction (GO:0035024)	3.54134387
63	glycerol ether metabolic process (GO:0006662)	3.46967181
64	cranial nerve morphogenesis (GO:0021602)	3.34083812
65	cerebral cortex neuron differentiation (GO:0021895)	3.30905895
66	ether metabolic process (GO:0018904)	3.27367828
67	organic cation transport (GO:0015695)	3.25901460
68	musculoskeletal movement (GO:0050881)	3.23253984
69	multicellular organismal movement (GO:0050879)	3.23253984
70	microtubule nucleation (GO:0007020)	3.22990371
71	piRNA metabolic process (GO:0034587)	3.14922815
72	cell recognition (GO:0008037)	3.11953478
73	polyamine biosynthetic process (GO:0006596)	3.08515730
74	DNA methylation involved in gamete generation (GO:0043046)	3.03861520
75	negative regulation of gene expression, epigenetic (GO:0045814)	3.03782992
76	male meiosis I (GO:0007141)	3.02627974
77	axoneme assembly (GO:0035082)	3.00931157
78	histone H3-K9 demethylation (GO:0033169)	2.99882520
79	intra-Golgi vesicle-mediated transport (GO:0006891)	2.90941587
80	protein-DNA complex disassembly (GO:0032986)	2.88561773
81	nucleosome disassembly (GO:0006337)	2.88561773
82	NAD biosynthetic process (GO:0009435)	2.88002688
83	regulation of somitogenesis (GO:0014807)	2.84969669
84	peptidyl-threonine dephosphorylation (GO:0035970)	2.82177331
85	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.81031085
86	multicellular organismal development (GO:0007275)	2.80610908
87	response to acidic pH (GO:0010447)	2.77485029
88	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.75726771
89	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.75428349
90	male meiosis (GO:0007140)	2.74952842
91	cell differentiation involved in metanephros development (GO:0072202)	2.74776049
92	cellular response to pH (GO:0071467)	2.70339481
93	ventricular system development (GO:0021591)	2.69420403
94	cilium assembly (GO:0042384)	2.68975960
95	cilium organization (GO:0044782)	2.67829411
96	neurofilament cytoskeleton organization (GO:0060052)	2.61984622
97	spinal cord motor neuron differentiation (GO:0021522)	2.60047923
98	acrosome reaction (GO:0007340)	11.4270439
99	sperm motility (GO:0030317)	10.9070713
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.1031567

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.46035222
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.98017953
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.92236140
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48344258
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45613170
6	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.45613170
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.44392229
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42013360
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40766885
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.38246930
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.38246930
12	FUS_26573619_Chip-Seq_HEK293_Human	2.35745647
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21448672
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.02963630
15	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.00548435
16	ERA_21632823_ChIP-Seq_H3396_Human	1.98922933
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95931761
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.93602297
19	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.80874172
20	VDR_22108803_ChIP-Seq_LS180_Human	1.77625748
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.73978064
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.73726237
23	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.71817671
24	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.70455891
25	P300_19829295_ChIP-Seq_ESCs_Human	1.70387668
26	RAC3_21632823_ChIP-Seq_H3396_Human	1.67054504
27	MYC_19829295_ChIP-Seq_ESCs_Human	1.66966091
28	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.66455970
29	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.66005707
30	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.65774613
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64190306
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63080540
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59204475
34	AR_25329375_ChIP-Seq_VCAP_Human	1.57977387
35	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56805192
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.56231304
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.54414494
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52006768
39	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.49549708
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.48180436
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46225701
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.45682058
43	DROSHA_22980978_ChIP-Seq_HELA_Human	1.45286943
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44106940
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.43430258
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40392341
47	BCL6_27268052_Chip-Seq_Bcells_Human	1.38090590
48	E2F1_20622854_ChIP-Seq_HELA_Human	1.37810183
49	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.36865658
50	RBPJ_21746931_ChIP-Seq_IB4_Human	1.33632689
51	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.33310107
52	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32992372
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.32926228
54	ETV1_20927104_ChIP-Seq_GIST48_Human	1.32201749
55	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.31628928
56	TP53_18474530_ChIP-ChIP_U2OS_Human	1.31533254
57	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.31082130
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.29198260
59	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29067825
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28965427
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28565313
62	CTCF_20526341_ChIP-Seq_ESCs_Human	1.28452964
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28241712
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28146621
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26715139
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26200523
67	TBL1_22424771_ChIP-Seq_293T_Human	1.25559219
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24598710
69	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.24223884
70	STAT3_23295773_ChIP-Seq_U87_Human	1.22642206
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22389114
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22389114
73	NFYB_21822215_ChIP-Seq_K562_Human	1.22324142
74	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20122019
75	NCOR_22424771_ChIP-Seq_293T_Human	1.19910654
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17771364
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17571935
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.16853592
79	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16453410
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15811733
81	P68_20966046_ChIP-Seq_HELA_Human	1.15112382
82	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.14719521
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.13852497
84	BCOR_27268052_Chip-Seq_Bcells_Human	1.13035131
85	P300_27268052_Chip-Seq_Bcells_Human	1.12918547
86	SMC4_20622854_ChIP-Seq_HELA_Human	1.11534852
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10252185
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.08752317
89	ERG_20517297_ChIP-Seq_VCAP_Human	1.08665849
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.07795807
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07627331
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.07232966
93	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.06765916
94	TP63_22573176_ChIP-Seq_HFKS_Human	1.06429668
95	NFYA_21822215_ChIP-Seq_K562_Human	1.05365851
96	GBX2_23144817_ChIP-Seq_PC3_Human	1.04706338
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03749406
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03504924
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02998491
100	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.02964118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.50081737
2	MP0003878_abnormal_ear_physiology	4.50081737
3	MP0005670_abnormal_white_adipose	4.38842069
4	MP0003698_abnormal_male_reproductive	3.95081085
5	MP0001929_abnormal_gametogenesis	3.37465814
6	MP0001348_abnormal_lacrimal_gland	2.79266951
7	MP0003646_muscle_fatigue	2.37696210
8	MP0005423_abnormal_somatic_nervous	2.15574877
9	MP0002161_abnormal_fertility/fecundity	2.12924597
10	MP0003718_maternal_effect	2.04554536
11	MP0003011_delayed_dark_adaptation	2.00573721
12	MP0005410_abnormal_fertilization	10.4456369
13	MP0000678_abnormal_parathyroid_gland	1.93622848
14	MP0008877_abnormal_DNA_methylation	1.88980234
15	MP0001486_abnormal_startle_reflex	1.85128282
16	MP0002132_abnormal_respiratory_system	1.84104236
17	MP0003880_abnormal_central_pattern	1.75410423
18	MP0002210_abnormal_sex_determination	1.67894593
19	MP0005379_endocrine/exocrine_gland_phen	1.66095732
20	MP0001485_abnormal_pinna_reflex	1.65752232
21	MP0002234_abnormal_pharynx_morphology	1.59323226
22	MP0006292_abnormal_olfactory_placode	1.55659345
23	MP0002138_abnormal_hepatobiliary_system	1.53676149
24	MP0004742_abnormal_vestibular_system	1.53418366
25	MP0001968_abnormal_touch/_nociception	1.52301453
26	MP0005551_abnormal_eye_electrophysiolog	1.46113533
27	MP0002653_abnormal_ependyma_morphology	1.45631182
28	MP0004859_abnormal_synaptic_plasticity	1.39596565
29	MP0001145_abnormal_male_reproductive	1.35529766
30	MP0002735_abnormal_chemical_nociception	1.34992236
31	MP0003787_abnormal_imprinting	1.31920673
32	MP0000653_abnormal_sex_gland	1.29290399
33	MP0002822_catalepsy	1.27398183
34	MP0001984_abnormal_olfaction	1.22167037
35	MP0003879_abnormal_hair_cell	1.17342800
36	MP0002249_abnormal_larynx_morphology	1.14353864
37	MP0001963_abnormal_hearing_physiology	1.13765574
38	MP0006276_abnormal_autonomic_nervous	1.11620999
39	MP0000026_abnormal_inner_ear	1.10933846
40	MP0005248_abnormal_Harderian_gland	1.10148713
41	MP0002229_neurodegeneration	1.08748714
42	MP0002282_abnormal_trachea_morphology	1.08401952
43	MP0000955_abnormal_spinal_cord	1.07165192
44	MP0003136_yellow_coat_color	1.05078020
45	MP0002733_abnormal_thermal_nociception	1.04245232
46	MP0002272_abnormal_nervous_system	1.02520136
47	MP0005253_abnormal_eye_physiology	1.02253249
48	MP0005367_renal/urinary_system_phenotyp	1.01627409
49	MP0000516_abnormal_urinary_system	1.01627409
50	MP0005310_abnormal_salivary_gland	1.00417309
51	MP0009745_abnormal_behavioral_response	0.99596255
52	MP0002572_abnormal_emotion/affect_behav	0.99136067
53	MP0002067_abnormal_sensory_capabilities	0.98290982
54	MP0002557_abnormal_social/conspecific_i	0.97082913
55	MP0009053_abnormal_anal_canal	0.96513993
56	MP0008995_early_reproductive_senescence	0.96246918
57	MP0004510_myositis	0.94133562
58	MP0002127_abnormal_cardiovascular_syste	0.93794290
59	MP0005395_other_phenotype	0.92826718
60	MP0008789_abnormal_olfactory_epithelium	0.92007241
61	MP0001765_abnormal_ion_homeostasis	0.87105157
62	MP0001970_abnormal_pain_threshold	0.86813449
63	MP0004085_abnormal_heartbeat	0.86280331
64	MP0001905_abnormal_dopamine_level	0.85659776
65	MP0000681_abnormal_thyroid_gland	0.84040079
66	MP0005394_taste/olfaction_phenotype	0.80630280
67	MP0005499_abnormal_olfactory_system	0.80630280
68	MP0009115_abnormal_fat_cell	0.78949107
69	MP0002837_dystrophic_cardiac_calcinosis	0.76924594
70	MP0000534_abnormal_ureter_morphology	0.76791219
71	MP0009046_muscle_twitch	0.75725988
72	MP0000049_abnormal_middle_ear	0.75166267
73	MP0003635_abnormal_synaptic_transmissio	0.73213900
74	MP0001501_abnormal_sleep_pattern	0.72982424
75	MP0002928_abnormal_bile_duct	0.72424295
76	MP0000569_abnormal_digit_pigmentation	0.69362034
77	MP0005084_abnormal_gallbladder_morpholo	0.68511169
78	MP0004484_altered_response_of	0.68219152
79	MP0003137_abnormal_impulse_conducting	0.68199629
80	MP0002752_abnormal_somatic_nervous	0.66409528
81	MP0002734_abnormal_mechanical_nocicepti	0.66333568
82	MP0000778_abnormal_nervous_system	0.65775331
83	MP0002882_abnormal_neuron_morphology	0.64933299
84	MP0003121_genomic_imprinting	0.62951038
85	MP0005666_abnormal_adipose_tissue	0.60371448
86	MP0005645_abnormal_hypothalamus_physiol	0.58623149
87	MP0003119_abnormal_digestive_system	0.53483527
88	MP0001440_abnormal_grooming_behavior	0.52992863
89	MP0008569_lethality_at_weaning	0.52233981
90	MP0005636_abnormal_mineral_homeostasis	0.51649098
91	MP0002064_seizures	0.50916150
92	MP0005535_abnormal_body_temperature	0.50837888
93	MP0002736_abnormal_nociception_after	0.50728777
94	MP0005391_vision/eye_phenotype	0.50387206
95	MP0000015_abnormal_ear_pigmentation	0.50207342
96	MP0000230_abnormal_systemic_arterial	0.49299871
97	MP0008775_abnormal_heart_ventricle	0.48982928
98	MP0002063_abnormal_learning/memory/cond	0.48880870
99	MP0004885_abnormal_endolymph	0.48879864
100	MP0001879_abnormal_lymphatic_vessel	0.47378676

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.77840789
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.30787608
3	Absent/shortened dynein arms (HP:0200106)	6.30787608
4	Bony spicule pigmentary retinopathy (HP:0007737)	4.87841573
5	Abnormal ciliary motility (HP:0012262)	4.86407772
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.73049179
7	Abnormal respiratory motile cilium morphology (HP:0005938)	4.73049179
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.61694064
9	Attenuation of retinal blood vessels (HP:0007843)	4.61138915
10	Tubulointerstitial nephritis (HP:0001970)	4.60565029
11	Chronic hepatic failure (HP:0100626)	4.51019940
12	Abnormal rod and cone electroretinograms (HP:0008323)	4.29200219
13	Abnormality of macular pigmentation (HP:0008002)	4.07727966
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.94695783
15	Hyperkalemia (HP:0002153)	3.83117941
16	Asymmetric septal hypertrophy (HP:0001670)	3.76673317
17	Infertility (HP:0000789)	3.67510434
18	Nephronophthisis (HP:0000090)	3.64951089
19	Hypoplastic ischia (HP:0003175)	3.45196210
20	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.45004469
21	Bell-shaped thorax (HP:0001591)	3.35822629
22	Resting tremor (HP:0002322)	3.31587392
23	Potter facies (HP:0002009)	3.24502343
24	Facial shape deformation (HP:0011334)	3.24502343
25	Male infertility (HP:0003251)	3.24170305
26	Nasal polyposis (HP:0100582)	3.23655479
27	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.17385209
28	Abnormality of the renal medulla (HP:0100957)	3.13130086
29	Abnormality of the ischium (HP:0003174)	3.12590488
30	Enlarged epiphyses (HP:0010580)	3.11464372
31	Impulsivity (HP:0100710)	3.03654795
32	Amelogenesis imperfecta (HP:0000705)	2.91155812
33	Hypoplasia of the thymus (HP:0000778)	2.86537958
34	Cone-rod dystrophy (HP:0000548)	2.86041053
35	Azoospermia (HP:0000027)	2.85786342
36	Congenital malformation of the right heart (HP:0011723)	2.83666795
37	Double outlet right ventricle (HP:0001719)	2.83666795
38	Abnormal spermatogenesis (HP:0008669)	2.80431142
39	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.78740335
40	Abnormality of dental color (HP:0011073)	2.77607292
41	Rhinitis (HP:0012384)	2.68686118
42	Renal dysplasia (HP:0000110)	2.68665315
43	Abnormal urine output (HP:0012590)	2.67525687
44	Stage 5 chronic kidney disease (HP:0003774)	2.60454235
45	Progressive cerebellar ataxia (HP:0002073)	2.54115089
46	Polydipsia (HP:0001959)	2.51355065
47	Abnormal drinking behavior (HP:0030082)	2.51355065
48	Abnormality of the nasal mucosa (HP:0000433)	2.42601866
49	Abnormality of the aortic arch (HP:0012303)	2.42096400
50	Unilateral renal agenesis (HP:0000122)	2.39917740
51	Tubulointerstitial abnormality (HP:0001969)	2.37862799
52	Polyuria (HP:0000103)	2.37147955
53	Abnormality of potassium homeostasis (HP:0011042)	2.36194343
54	Chronic bronchitis (HP:0004469)	2.34099699
55	Truncal obesity (HP:0001956)	2.31511441
56	Pendular nystagmus (HP:0012043)	2.31231856
57	Abnormality of the parathyroid morphology (HP:0011766)	2.28459376
58	Abnormality of renal excretion (HP:0011036)	2.27413077
59	Optic nerve hypoplasia (HP:0000609)	2.25245126
60	Postural instability (HP:0002172)	2.25132732
61	Pancreatic fibrosis (HP:0100732)	2.24493738
62	Myokymia (HP:0002411)	2.23921873
63	Osteomalacia (HP:0002749)	2.17408836
64	Pancreatic cysts (HP:0001737)	2.15461466
65	Bronchiectasis (HP:0002110)	2.08600836
66	Congenital stationary night blindness (HP:0007642)	2.06401056
67	Decreased central vision (HP:0007663)	2.03083018
68	Abnormality of midbrain morphology (HP:0002418)	2.02065717
69	Molar tooth sign on MRI (HP:0002419)	2.02065717
70	Occipital encephalocele (HP:0002085)	2.01039153
71	Type 2 muscle fiber atrophy (HP:0003554)	2.00535506
72	Abnormality of the costochondral junction (HP:0000919)	1.99584581
73	Muscle fiber atrophy (HP:0100295)	1.99554459
74	Tubular atrophy (HP:0000092)	1.97953847
75	Portal hypertension (HP:0001409)	1.96809846
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95449111
77	Abnormality of the pubic bones (HP:0003172)	1.89920966
78	Failure to thrive in infancy (HP:0001531)	1.88892737
79	Cerebellar dysplasia (HP:0007033)	1.86933867
80	Generalized aminoaciduria (HP:0002909)	1.86880065
81	Photophobia (HP:0000613)	1.80887281
82	Hypophosphatemic rickets (HP:0004912)	1.78758315
83	Abnormality of the hepatic vasculature (HP:0006707)	1.78421587
84	Type II lissencephaly (HP:0007260)	1.77830000
85	Intellectual disability, moderate (HP:0002342)	1.77144655
86	Tetany (HP:0001281)	1.76601357
87	Sclerocornea (HP:0000647)	1.75801184
88	Atonic seizures (HP:0010819)	1.75612287
89	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.74752087
90	Renal Fanconi syndrome (HP:0001994)	1.72545065
91	Hypoalphalipoproteinemia (HP:0003233)	1.70447190
92	Widely patent fontanelles and sutures (HP:0004492)	1.70415610
93	Abnormality of the femoral head (HP:0003368)	1.67828776
94	Recurrent corneal erosions (HP:0000495)	1.67725387
95	Anencephaly (HP:0002323)	1.66899395
96	Epiphyseal dysplasia (HP:0002656)	1.65358841
97	Absent epiphyses (HP:0010577)	1.64774386
98	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.64774386
99	Amblyopia (HP:0000646)	1.63839507
100	Hypokalemia (HP:0002900)	1.63349148

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.67185131
2	TESK1	4.64445662
3	MAP4K2	4.22090008
4	DDR2	3.93609115
5	INSRR	3.72450436
6	PLK2	3.27064690
7	PNCK	3.01874242
8	BRD4	2.98935749
9	STK38	2.55390062
10	PRKD3	2.55147460
11	STK38L	2.43497317
12	CAMK1G	2.04800136
13	MAPK15	1.99780431
14	LATS1	1.89666278
15	WNK1	1.68630129
16	PIK3CG	1.56712376
17	FRK	1.39216259
18	PDPK1	1.33740236
19	PDK1	1.30360673
20	MARK1	1.23648869
21	ZAK	1.21166551
22	PINK1	1.20025719
23	CDK19	1.14461841
24	DYRK1B	1.13811370
25	WNK4	1.09694888
26	CDK7	1.00899228
27	WNK3	0.99444728
28	MAP3K4	0.95197757
29	MST1R	0.94923561
30	NUAK1	0.94393962
31	BMPR1B	0.93050616
32	PTK2B	0.92819045
33	ADRBK2	0.89688402
34	MAP2K7	0.88116268
35	MAP3K9	0.87872061
36	CDK3	0.86802045
37	NEK6	0.82181433
38	CAMK1D	0.81771262
39	LATS2	0.81579640
40	MAPK13	0.81078208
41	AKT3	0.79470414
42	SIK2	0.75759324
43	PRKCG	0.73939717
44	TYRO3	0.71760691
45	PRKAA2	0.69900140
46	CAMK1	0.69288865
47	OXSR1	0.68364142
48	PRKG1	0.67940157
49	UHMK1	0.65763392
50	NTRK3	0.60555247
51	DYRK2	0.59188115
52	STK39	0.57128657
53	KSR2	0.56880400
54	BCKDK	0.55878050
55	GRK1	0.53538824
56	BRAF	0.52727226
57	MAP2K2	0.52716560
58	MAP3K2	0.49805501
59	MAP3K11	0.48081321
60	RPS6KA2	0.47098360
61	RPS6KA1	0.46978492
62	GSK3B	0.46447843
63	MINK1	0.43492442
64	CDK2	0.41607098
65	CDK12	0.41040544
66	SGK494	0.40892161
67	SGK223	0.40892161
68	CDK1	0.39796041
69	PRKCE	0.39588322
70	CAMK4	0.38697156
71	MUSK	0.37954188
72	TNK2	0.37930594
73	MAPK1	0.37514214
74	TIE1	0.37165662
75	PRKCZ	0.36634932
76	MAPK8	0.32807265
77	SGK1	0.32192694
78	TAOK3	0.31380131
79	PRKG2	0.29730484
80	ROCK1	0.29306826
81	PKN1	0.29244319
82	CHEK1	0.28200398
83	PRKACA	0.26240632
84	MAPK14	0.25499709
85	ARAF	0.25467390
86	OBSCN	0.25210994
87	CAMK2A	0.23675517
88	TRIM28	0.22741594
89	PRKCB	0.22492267
90	PRKAA1	0.21648750
91	ACVR1B	0.20986982
92	PRKACB	0.20042501
93	AKT1	0.19678334
94	RPS6KA6	0.19503252
95	DYRK3	0.18942853
96	MARK2	0.18285314
97	MKNK2	0.18264670
98	CSNK1A1	0.17907408
99	CDK4	0.17216089
100	CASK	0.17169137

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.40971789
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.47642457
3	Olfactory transduction_Homo sapiens_hsa04740	3.87738953
4	Butanoate metabolism_Homo sapiens_hsa00650	2.56493676
5	Phototransduction_Homo sapiens_hsa04744	2.49647177
6	Taste transduction_Homo sapiens_hsa04742	2.31766938
7	Nicotine addiction_Homo sapiens_hsa05033	2.11709639
8	Allograft rejection_Homo sapiens_hsa05330	2.10296804
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.05256718
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.04294321
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.98336954
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.89379385
13	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.79444531
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73783004
15	RNA transport_Homo sapiens_hsa03013	1.56831580
16	Viral myocarditis_Homo sapiens_hsa05416	1.42252789
17	Basal transcription factors_Homo sapiens_hsa03022	1.38257691
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33836919
19	Morphine addiction_Homo sapiens_hsa05032	1.33183744
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.25624726
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25335741
22	Fatty acid degradation_Homo sapiens_hsa00071	1.22437008
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17959377
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.14059807
25	Type II diabetes mellitus_Homo sapiens_hsa04930	1.13064461
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.11102822
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.09216850
28	Salivary secretion_Homo sapiens_hsa04970	1.07369240
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.05458915
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.04277213
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03748550
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03470654
33	Oocyte meiosis_Homo sapiens_hsa04114	1.02188738
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.01835837
35	Circadian entrainment_Homo sapiens_hsa04713	0.99646986
36	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.99283308
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96942292
38	Phenylalanine metabolism_Homo sapiens_hsa00360	0.95655567
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93547931
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.90002709
41	Fat digestion and absorption_Homo sapiens_hsa04975	0.89717385
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89494913
43	cAMP signaling pathway_Homo sapiens_hsa04024	0.85245423
44	GABAergic synapse_Homo sapiens_hsa04727	0.83593284
45	Huntingtons disease_Homo sapiens_hsa05016	0.79320353
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76104506
47	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75727910
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75466290
49	Purine metabolism_Homo sapiens_hsa00230	0.73826871
50	Retinol metabolism_Homo sapiens_hsa00830	0.73112290
51	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.71905819
52	Insulin secretion_Homo sapiens_hsa04911	0.70955477
53	Regulation of autophagy_Homo sapiens_hsa04140	0.70748656
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.69680510
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69117083
56	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.68660020
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.65759147
58	Asthma_Homo sapiens_hsa05310	0.62591296
59	Endocytosis_Homo sapiens_hsa04144	0.61390819
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60027181
61	Serotonergic synapse_Homo sapiens_hsa04726	0.59758431
62	ABC transporters_Homo sapiens_hsa02010	0.59165640
63	Propanoate metabolism_Homo sapiens_hsa00640	0.58894456
64	Peroxisome_Homo sapiens_hsa04146	0.57862196
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57022537
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56660494
67	Cholinergic synapse_Homo sapiens_hsa04725	0.55546556
68	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53935798
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53291946
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52191350
71	Arginine biosynthesis_Homo sapiens_hsa00220	0.47293659
72	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.47201831
73	Gastric acid secretion_Homo sapiens_hsa04971	0.46323255
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45585846
75	PPAR signaling pathway_Homo sapiens_hsa03320	0.45139495
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44487596
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.44373702
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43604235
79	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43314137
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42706633
81	Renin secretion_Homo sapiens_hsa04924	0.42488102
82	RNA degradation_Homo sapiens_hsa03018	0.41392642
83	Caffeine metabolism_Homo sapiens_hsa00232	0.40518741
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38416363
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.37696302
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36641977
87	Homologous recombination_Homo sapiens_hsa03440	0.36540086
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34140108
89	Metabolic pathways_Homo sapiens_hsa01100	0.33771576
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.33417466
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33216883
92	Influenza A_Homo sapiens_hsa05164	0.31698799
93	Amphetamine addiction_Homo sapiens_hsa05031	0.31234556
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30913054
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30213453
96	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.23228555
97	Circadian rhythm_Homo sapiens_hsa04710	0.23042804
98	Bile secretion_Homo sapiens_hsa04976	0.22550348
99	Long-term potentiation_Homo sapiens_hsa04720	0.22231136
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.22214227

NPIPB6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »