NPIPB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.86483321
2chromosome condensation (GO:0030261)8.45165478
3single strand break repair (GO:0000012)8.40285920
4DNA packaging (GO:0006323)8.11471215
5sperm capacitation (GO:0048240)8.02687731
6microtubule depolymerization (GO:0007019)7.72873528
7plasma membrane fusion (GO:0045026)7.66277681
8spermatid nucleus differentiation (GO:0007289)7.56422918
9spermatid development (GO:0007286)7.53388939
10sperm-egg recognition (GO:0035036)7.17594368
11protein polyglutamylation (GO:0018095)6.86775790
12protein targeting to Golgi (GO:0000042)6.78937452
13multicellular organism reproduction (GO:0032504)6.76210320
14establishment of protein localization to Golgi (GO:0072600)6.59752411
15binding of sperm to zona pellucida (GO:0007339)6.57781811
16microtubule polymerization or depolymerization (GO:0031109)6.43472166
17calcium ion-dependent exocytosis (GO:0017156)6.42088757
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.37711904
19reproduction (GO:0000003)6.33579326
20axonemal dynein complex assembly (GO:0070286)6.32534985
21rRNA methylation (GO:0031167)6.28352239
22sexual reproduction (GO:0019953)6.02138298
23cell-cell recognition (GO:0009988)5.94623799
24phosphatidylethanolamine biosynthetic process (GO:0006646)5.82082056
25spermatogenesis (GO:0007283)5.68372620
26male gamete generation (GO:0048232)5.66840719
27centriole replication (GO:0007099)5.59555455
28phosphatidylethanolamine metabolic process (GO:0046337)5.44575392
29negative regulation of inclusion body assembly (GO:0090084)5.33291337
30regulation of cilium movement (GO:0003352)5.29973399
31rRNA modification (GO:0000154)5.26093036
32cellular ketone body metabolic process (GO:0046950)5.20542351
33gamete generation (GO:0007276)5.20259307
34microtubule severing (GO:0051013)5.20165792
35protein localization to Golgi apparatus (GO:0034067)5.06146684
36motile cilium assembly (GO:0044458)4.93344017
37cilium or flagellum-dependent cell motility (GO:0001539)4.84327245
38positive regulation of Rab GTPase activity (GO:0032851)4.84208462
39regulation of Rab GTPase activity (GO:0032313)4.84208462
40epithelial cilium movement (GO:0003351)4.74456795
41centriole assembly (GO:0098534)4.68143374
42single fertilization (GO:0007338)4.64634587
43ketone body metabolic process (GO:1902224)4.58180363
44seminiferous tubule development (GO:0072520)4.54586819
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52902369
46chromatin silencing (GO:0006342)4.36879300
47germ cell development (GO:0007281)4.24360196
48regulation of centriole replication (GO:0046599)4.15892137
49coenzyme catabolic process (GO:0009109)4.13675159
50cell wall macromolecule catabolic process (GO:0016998)4.13674781
51multicellular organismal reproductive process (GO:0048609)4.11512868
52cilium movement (GO:0003341)4.07139783
53regulation of transcription involved in cell fate commitment (GO:0060850)4.05392676
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.04142618
55RNA destabilization (GO:0050779)4.00959768
56cell wall macromolecule metabolic process (GO:0044036)3.92851308
57regulation of inclusion body assembly (GO:0090083)3.83163514
58fertilization (GO:0009566)3.81115554
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73800302
60regulation of microtubule-based movement (GO:0060632)3.73079505
61nucleus organization (GO:0006997)3.56638325
62negative regulation of Rho protein signal transduction (GO:0035024)3.54134387
63glycerol ether metabolic process (GO:0006662)3.46967181
64cranial nerve morphogenesis (GO:0021602)3.34083812
65cerebral cortex neuron differentiation (GO:0021895)3.30905895
66ether metabolic process (GO:0018904)3.27367828
67organic cation transport (GO:0015695)3.25901460
68multicellular organismal movement (GO:0050879)3.23253984
69musculoskeletal movement (GO:0050881)3.23253984
70microtubule nucleation (GO:0007020)3.22990371
71piRNA metabolic process (GO:0034587)3.14922815
72cell recognition (GO:0008037)3.11953478
73polyamine biosynthetic process (GO:0006596)3.08515730
74DNA methylation involved in gamete generation (GO:0043046)3.03861520
75negative regulation of gene expression, epigenetic (GO:0045814)3.03782992
76male meiosis I (GO:0007141)3.02627974
77axoneme assembly (GO:0035082)3.00931157
78histone H3-K9 demethylation (GO:0033169)2.99882520
79intra-Golgi vesicle-mediated transport (GO:0006891)2.90941587
80protein-DNA complex disassembly (GO:0032986)2.88561773
81nucleosome disassembly (GO:0006337)2.88561773
82NAD biosynthetic process (GO:0009435)2.88002688
83regulation of somitogenesis (GO:0014807)2.84969669
84peptidyl-threonine dephosphorylation (GO:0035970)2.82177331
85detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.81031085
86multicellular organismal development (GO:0007275)2.80610908
87response to acidic pH (GO:0010447)2.77485029
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.75726771
89regulation of phosphoprotein phosphatase activity (GO:0043666)2.75428349
90male meiosis (GO:0007140)2.74952842
91cell differentiation involved in metanephros development (GO:0072202)2.74776049
92cellular response to pH (GO:0071467)2.70339481
93ventricular system development (GO:0021591)2.69420403
94cilium assembly (GO:0042384)2.68975960
95cilium organization (GO:0044782)2.67829411
96neurofilament cytoskeleton organization (GO:0060052)2.61984622
97spinal cord motor neuron differentiation (GO:0021522)2.60047923
98acrosome reaction (GO:0007340)11.4270439
99sperm motility (GO:0030317)10.9070713
100fusion of sperm to egg plasma membrane (GO:0007342)10.1031567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.46035222
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.98017953
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92236140
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.48344258
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.45613170
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45613170
7EZH2_22144423_ChIP-Seq_EOC_Human2.44392229
8ZNF274_21170338_ChIP-Seq_K562_Hela2.42013360
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.40766885
10CBP_20019798_ChIP-Seq_JUKART_Human2.38246930
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.38246930
12FUS_26573619_Chip-Seq_HEK293_Human2.35745647
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21448672
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02963630
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.00548435
16ERA_21632823_ChIP-Seq_H3396_Human1.98922933
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95931761
18ER_23166858_ChIP-Seq_MCF-7_Human1.93602297
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.80874172
20VDR_22108803_ChIP-Seq_LS180_Human1.77625748
21TAF15_26573619_Chip-Seq_HEK293_Human1.73978064
22NANOG_20526341_ChIP-Seq_ESCs_Human1.73726237
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.71817671
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70455891
25P300_19829295_ChIP-Seq_ESCs_Human1.70387668
26RAC3_21632823_ChIP-Seq_H3396_Human1.67054504
27MYC_19829295_ChIP-Seq_ESCs_Human1.66966091
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.66455970
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.66005707
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65774613
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.64190306
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63080540
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59204475
34AR_25329375_ChIP-Seq_VCAP_Human1.57977387
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56805192
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56231304
37TAF2_19829295_ChIP-Seq_ESCs_Human1.54414494
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.52006768
39KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49549708
40AR_21572438_ChIP-Seq_LNCaP_Human1.48180436
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.46225701
42OCT4_20526341_ChIP-Seq_ESCs_Human1.45682058
43DROSHA_22980978_ChIP-Seq_HELA_Human1.45286943
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44106940
45CTCF_27219007_Chip-Seq_Bcells_Human1.43430258
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.40392341
47BCL6_27268052_Chip-Seq_Bcells_Human1.38090590
48E2F1_20622854_ChIP-Seq_HELA_Human1.37810183
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.36865658
50RBPJ_21746931_ChIP-Seq_IB4_Human1.33632689
51CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33310107
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32992372
53PHF8_20622854_ChIP-Seq_HELA_Human1.32926228
54ETV1_20927104_ChIP-Seq_GIST48_Human1.32201749
55SMAD3_21741376_ChIP-Seq_ESCs_Human1.31628928
56TP53_18474530_ChIP-ChIP_U2OS_Human1.31533254
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.31082130
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29198260
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.29067825
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28965427
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28565313
62CTCF_20526341_ChIP-Seq_ESCs_Human1.28452964
63RUNX2_22187159_ChIP-Seq_PCA_Human1.28241712
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.28146621
65HOXB7_26014856_ChIP-Seq_BT474_Human1.26715139
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26200523
67TBL1_22424771_ChIP-Seq_293T_Human1.25559219
68SMAD4_21799915_ChIP-Seq_A2780_Human1.24598710
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.24223884
70STAT3_23295773_ChIP-Seq_U87_Human1.22642206
71SOX2_19829295_ChIP-Seq_ESCs_Human1.22389114
72NANOG_19829295_ChIP-Seq_ESCs_Human1.22389114
73NFYB_21822215_ChIP-Seq_K562_Human1.22324142
74CEBPB_22108803_ChIP-Seq_LS180_Human1.20122019
75NCOR_22424771_ChIP-Seq_293T_Human1.19910654
76REST_21632747_ChIP-Seq_MESCs_Mouse1.17771364
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.17571935
78PHF8_20622853_ChIP-Seq_HELA_Human1.16853592
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16453410
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.15811733
81P68_20966046_ChIP-Seq_HELA_Human1.15112382
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14719521
83P53_21459846_ChIP-Seq_SAOS-2_Human1.13852497
84BCOR_27268052_Chip-Seq_Bcells_Human1.13035131
85P300_27268052_Chip-Seq_Bcells_Human1.12918547
86SMC4_20622854_ChIP-Seq_HELA_Human1.11534852
87GATA6_21074721_ChIP-Seq_CACO-2_Human1.10252185
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08752317
89ERG_20517297_ChIP-Seq_VCAP_Human1.08665849
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.07795807
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07627331
92SMRT_27268052_Chip-Seq_Bcells_Human1.07232966
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06765916
94TP63_22573176_ChIP-Seq_HFKS_Human1.06429668
95NFYA_21822215_ChIP-Seq_K562_Human1.05365851
96GBX2_23144817_ChIP-Seq_PC3_Human1.04706338
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03749406
98FOXH1_21741376_ChIP-Seq_EPCs_Human1.03504924
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02998491
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02964118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.50081737
2MP0003878_abnormal_ear_physiology4.50081737
3MP0005670_abnormal_white_adipose4.38842069
4MP0003698_abnormal_male_reproductive3.95081085
5MP0001929_abnormal_gametogenesis3.37465814
6MP0001348_abnormal_lacrimal_gland2.79266951
7MP0003646_muscle_fatigue2.37696210
8MP0005423_abnormal_somatic_nervous2.15574877
9MP0002161_abnormal_fertility/fecundity2.12924597
10MP0003718_maternal_effect2.04554536
11MP0003011_delayed_dark_adaptation2.00573721
12MP0005410_abnormal_fertilization10.4456369
13MP0000678_abnormal_parathyroid_gland1.93622848
14MP0008877_abnormal_DNA_methylation1.88980234
15MP0001486_abnormal_startle_reflex1.85128282
16MP0002132_abnormal_respiratory_system1.84104236
17MP0003880_abnormal_central_pattern1.75410423
18MP0002210_abnormal_sex_determination1.67894593
19MP0005379_endocrine/exocrine_gland_phen1.66095732
20MP0001485_abnormal_pinna_reflex1.65752232
21MP0002234_abnormal_pharynx_morphology1.59323226
22MP0006292_abnormal_olfactory_placode1.55659345
23MP0002138_abnormal_hepatobiliary_system1.53676149
24MP0004742_abnormal_vestibular_system1.53418366
25MP0001968_abnormal_touch/_nociception1.52301453
26MP0005551_abnormal_eye_electrophysiolog1.46113533
27MP0002653_abnormal_ependyma_morphology1.45631182
28MP0004859_abnormal_synaptic_plasticity1.39596565
29MP0001145_abnormal_male_reproductive1.35529766
30MP0002735_abnormal_chemical_nociception1.34992236
31MP0003787_abnormal_imprinting1.31920673
32MP0000653_abnormal_sex_gland1.29290399
33MP0002822_catalepsy1.27398183
34MP0001984_abnormal_olfaction1.22167037
35MP0003879_abnormal_hair_cell1.17342800
36MP0002249_abnormal_larynx_morphology1.14353864
37MP0001963_abnormal_hearing_physiology1.13765574
38MP0006276_abnormal_autonomic_nervous1.11620999
39MP0000026_abnormal_inner_ear1.10933846
40MP0005248_abnormal_Harderian_gland1.10148713
41MP0002229_neurodegeneration1.08748714
42MP0002282_abnormal_trachea_morphology1.08401952
43MP0000955_abnormal_spinal_cord1.07165192
44MP0003136_yellow_coat_color1.05078020
45MP0002733_abnormal_thermal_nociception1.04245232
46MP0002272_abnormal_nervous_system1.02520136
47MP0005253_abnormal_eye_physiology1.02253249
48MP0000516_abnormal_urinary_system1.01627409
49MP0005367_renal/urinary_system_phenotyp1.01627409
50MP0005310_abnormal_salivary_gland1.00417309
51MP0009745_abnormal_behavioral_response0.99596255
52MP0002572_abnormal_emotion/affect_behav0.99136067
53MP0002067_abnormal_sensory_capabilities0.98290982
54MP0002557_abnormal_social/conspecific_i0.97082913
55MP0009053_abnormal_anal_canal0.96513993
56MP0008995_early_reproductive_senescence0.96246918
57MP0004510_myositis0.94133562
58MP0002127_abnormal_cardiovascular_syste0.93794290
59MP0005395_other_phenotype0.92826718
60MP0008789_abnormal_olfactory_epithelium0.92007241
61MP0001765_abnormal_ion_homeostasis0.87105157
62MP0001970_abnormal_pain_threshold0.86813449
63MP0004085_abnormal_heartbeat0.86280331
64MP0001905_abnormal_dopamine_level0.85659776
65MP0000681_abnormal_thyroid_gland0.84040079
66MP0005394_taste/olfaction_phenotype0.80630280
67MP0005499_abnormal_olfactory_system0.80630280
68MP0009115_abnormal_fat_cell0.78949107
69MP0002837_dystrophic_cardiac_calcinosis0.76924594
70MP0000534_abnormal_ureter_morphology0.76791219
71MP0009046_muscle_twitch0.75725988
72MP0000049_abnormal_middle_ear0.75166267
73MP0003635_abnormal_synaptic_transmissio0.73213900
74MP0001501_abnormal_sleep_pattern0.72982424
75MP0002928_abnormal_bile_duct0.72424295
76MP0000569_abnormal_digit_pigmentation0.69362034
77MP0005084_abnormal_gallbladder_morpholo0.68511169
78MP0004484_altered_response_of0.68219152
79MP0003137_abnormal_impulse_conducting0.68199629
80MP0002752_abnormal_somatic_nervous0.66409528
81MP0002734_abnormal_mechanical_nocicepti0.66333568
82MP0000778_abnormal_nervous_system0.65775331
83MP0002882_abnormal_neuron_morphology0.64933299
84MP0003121_genomic_imprinting0.62951038
85MP0005666_abnormal_adipose_tissue0.60371448
86MP0005645_abnormal_hypothalamus_physiol0.58623149
87MP0003119_abnormal_digestive_system0.53483527
88MP0001440_abnormal_grooming_behavior0.52992863
89MP0008569_lethality_at_weaning0.52233981
90MP0005636_abnormal_mineral_homeostasis0.51649098
91MP0002064_seizures0.50916150
92MP0005535_abnormal_body_temperature0.50837888
93MP0002736_abnormal_nociception_after0.50728777
94MP0005391_vision/eye_phenotype0.50387206
95MP0000015_abnormal_ear_pigmentation0.50207342
96MP0000230_abnormal_systemic_arterial0.49299871
97MP0008775_abnormal_heart_ventricle0.48982928
98MP0002063_abnormal_learning/memory/cond0.48880870
99MP0004885_abnormal_endolymph0.48879864
100MP0001879_abnormal_lymphatic_vessel0.47378676

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.77840789
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.30787608
3Absent/shortened dynein arms (HP:0200106)6.30787608
4Bony spicule pigmentary retinopathy (HP:0007737)4.87841573
5Abnormal ciliary motility (HP:0012262)4.86407772
6Abnormal respiratory epithelium morphology (HP:0012253)4.73049179
7Abnormal respiratory motile cilium morphology (HP:0005938)4.73049179
8Abnormal respiratory motile cilium physiology (HP:0012261)4.61694064
9Attenuation of retinal blood vessels (HP:0007843)4.61138915
10Tubulointerstitial nephritis (HP:0001970)4.60565029
11Chronic hepatic failure (HP:0100626)4.51019940
12Abnormal rod and cone electroretinograms (HP:0008323)4.29200219
13Abnormality of macular pigmentation (HP:0008002)4.07727966
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.94695783
15Hyperkalemia (HP:0002153)3.83117941
16Asymmetric septal hypertrophy (HP:0001670)3.76673317
17Infertility (HP:0000789)3.67510434
18Nephronophthisis (HP:0000090)3.64951089
19Hypoplastic ischia (HP:0003175)3.45196210
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.45004469
21Bell-shaped thorax (HP:0001591)3.35822629
22Resting tremor (HP:0002322)3.31587392
23Potter facies (HP:0002009)3.24502343
24Facial shape deformation (HP:0011334)3.24502343
25Male infertility (HP:0003251)3.24170305
26Nasal polyposis (HP:0100582)3.23655479
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.17385209
28Abnormality of the renal medulla (HP:0100957)3.13130086
29Abnormality of the ischium (HP:0003174)3.12590488
30Enlarged epiphyses (HP:0010580)3.11464372
31Impulsivity (HP:0100710)3.03654795
32Amelogenesis imperfecta (HP:0000705)2.91155812
33Hypoplasia of the thymus (HP:0000778)2.86537958
34Cone-rod dystrophy (HP:0000548)2.86041053
35Azoospermia (HP:0000027)2.85786342
36Congenital malformation of the right heart (HP:0011723)2.83666795
37Double outlet right ventricle (HP:0001719)2.83666795
38Abnormal spermatogenesis (HP:0008669)2.80431142
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.78740335
40Abnormality of dental color (HP:0011073)2.77607292
41Rhinitis (HP:0012384)2.68686118
42Renal dysplasia (HP:0000110)2.68665315
43Abnormal urine output (HP:0012590)2.67525687
44Stage 5 chronic kidney disease (HP:0003774)2.60454235
45Progressive cerebellar ataxia (HP:0002073)2.54115089
46Abnormal drinking behavior (HP:0030082)2.51355065
47Polydipsia (HP:0001959)2.51355065
48Abnormality of the nasal mucosa (HP:0000433)2.42601866
49Abnormality of the aortic arch (HP:0012303)2.42096400
50Unilateral renal agenesis (HP:0000122)2.39917740
51Tubulointerstitial abnormality (HP:0001969)2.37862799
52Polyuria (HP:0000103)2.37147955
53Abnormality of potassium homeostasis (HP:0011042)2.36194343
54Chronic bronchitis (HP:0004469)2.34099699
55Truncal obesity (HP:0001956)2.31511441
56Pendular nystagmus (HP:0012043)2.31231856
57Abnormality of the parathyroid morphology (HP:0011766)2.28459376
58Abnormality of renal excretion (HP:0011036)2.27413077
59Optic nerve hypoplasia (HP:0000609)2.25245126
60Postural instability (HP:0002172)2.25132732
61Pancreatic fibrosis (HP:0100732)2.24493738
62Myokymia (HP:0002411)2.23921873
63Osteomalacia (HP:0002749)2.17408836
64Pancreatic cysts (HP:0001737)2.15461466
65Bronchiectasis (HP:0002110)2.08600836
66Congenital stationary night blindness (HP:0007642)2.06401056
67Decreased central vision (HP:0007663)2.03083018
68Abnormality of midbrain morphology (HP:0002418)2.02065717
69Molar tooth sign on MRI (HP:0002419)2.02065717
70Occipital encephalocele (HP:0002085)2.01039153
71Type 2 muscle fiber atrophy (HP:0003554)2.00535506
72Abnormality of the costochondral junction (HP:0000919)1.99584581
73Muscle fiber atrophy (HP:0100295)1.99554459
74Tubular atrophy (HP:0000092)1.97953847
75Portal hypertension (HP:0001409)1.96809846
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95449111
77Abnormality of the pubic bones (HP:0003172)1.89920966
78Failure to thrive in infancy (HP:0001531)1.88892737
79Cerebellar dysplasia (HP:0007033)1.86933867
80Generalized aminoaciduria (HP:0002909)1.86880065
81Photophobia (HP:0000613)1.80887281
82Hypophosphatemic rickets (HP:0004912)1.78758315
83Abnormality of the hepatic vasculature (HP:0006707)1.78421587
84Type II lissencephaly (HP:0007260)1.77830000
85Intellectual disability, moderate (HP:0002342)1.77144655
86Tetany (HP:0001281)1.76601357
87Sclerocornea (HP:0000647)1.75801184
88Atonic seizures (HP:0010819)1.75612287
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.74752087
90Renal Fanconi syndrome (HP:0001994)1.72545065
91Hypoalphalipoproteinemia (HP:0003233)1.70447190
92Widely patent fontanelles and sutures (HP:0004492)1.70415610
93Abnormality of the femoral head (HP:0003368)1.67828776
94Recurrent corneal erosions (HP:0000495)1.67725387
95Anencephaly (HP:0002323)1.66899395
96Epiphyseal dysplasia (HP:0002656)1.65358841
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64774386
98Absent epiphyses (HP:0010577)1.64774386
99Amblyopia (HP:0000646)1.63839507
100Hypokalemia (HP:0002900)1.63349148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.67185131
2TESK14.64445662
3MAP4K24.22090008
4DDR23.93609115
5INSRR3.72450436
6PLK23.27064690
7PNCK3.01874242
8BRD42.98935749
9STK382.55390062
10PRKD32.55147460
11STK38L2.43497317
12CAMK1G2.04800136
13MAPK151.99780431
14LATS11.89666278
15WNK11.68630129
16PIK3CG1.56712376
17FRK1.39216259
18PDPK11.33740236
19PDK11.30360673
20MARK11.23648869
21ZAK1.21166551
22PINK11.20025719
23CDK191.14461841
24DYRK1B1.13811370
25WNK41.09694888
26CDK71.00899228
27WNK30.99444728
28MAP3K40.95197757
29MST1R0.94923561
30NUAK10.94393962
31BMPR1B0.93050616
32PTK2B0.92819045
33ADRBK20.89688402
34MAP2K70.88116268
35MAP3K90.87872061
36CDK30.86802045
37NEK60.82181433
38CAMK1D0.81771262
39LATS20.81579640
40MAPK130.81078208
41AKT30.79470414
42SIK20.75759324
43PRKCG0.73939717
44TYRO30.71760691
45PRKAA20.69900140
46CAMK10.69288865
47OXSR10.68364142
48PRKG10.67940157
49UHMK10.65763392
50NTRK30.60555247
51DYRK20.59188115
52STK390.57128657
53KSR20.56880400
54BCKDK0.55878050
55GRK10.53538824
56BRAF0.52727226
57MAP2K20.52716560
58MAP3K20.49805501
59MAP3K110.48081321
60RPS6KA20.47098360
61RPS6KA10.46978492
62GSK3B0.46447843
63MINK10.43492442
64CDK20.41607098
65CDK120.41040544
66SGK2230.40892161
67SGK4940.40892161
68CDK10.39796041
69PRKCE0.39588322
70CAMK40.38697156
71MUSK0.37954188
72TNK20.37930594
73MAPK10.37514214
74TIE10.37165662
75PRKCZ0.36634932
76MAPK80.32807265
77SGK10.32192694
78TAOK30.31380131
79PRKG20.29730484
80ROCK10.29306826
81PKN10.29244319
82CHEK10.28200398
83PRKACA0.26240632
84MAPK140.25499709
85ARAF0.25467390
86OBSCN0.25210994
87CAMK2A0.23675517
88TRIM280.22741594
89PRKCB0.22492267
90PRKAA10.21648750
91ACVR1B0.20986982
92PRKACB0.20042501
93AKT10.19678334
94RPS6KA60.19503252
95DYRK30.18942853
96MARK20.18285314
97MKNK20.18264670
98CSNK1A10.17907408
99CDK40.17216089
100CASK0.17169137

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.40971789
2Fatty acid biosynthesis_Homo sapiens_hsa000614.47642457
3Olfactory transduction_Homo sapiens_hsa047403.87738953
4Butanoate metabolism_Homo sapiens_hsa006502.56493676
5Phototransduction_Homo sapiens_hsa047442.49647177
6Taste transduction_Homo sapiens_hsa047422.31766938
7Nicotine addiction_Homo sapiens_hsa050332.11709639
8Allograft rejection_Homo sapiens_hsa053302.10296804
9Type I diabetes mellitus_Homo sapiens_hsa049402.05256718
10Autoimmune thyroid disease_Homo sapiens_hsa053202.04294321
11Dorso-ventral axis formation_Homo sapiens_hsa043201.98336954
12Graft-versus-host disease_Homo sapiens_hsa053321.89379385
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.79444531
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73783004
15RNA transport_Homo sapiens_hsa030131.56831580
16Viral myocarditis_Homo sapiens_hsa054161.42252789
17Basal transcription factors_Homo sapiens_hsa030221.38257691
18Cardiac muscle contraction_Homo sapiens_hsa042601.33836919
19Morphine addiction_Homo sapiens_hsa050321.33183744
20Antigen processing and presentation_Homo sapiens_hsa046121.25624726
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25335741
22Fatty acid degradation_Homo sapiens_hsa000711.22437008
23Fanconi anemia pathway_Homo sapiens_hsa034601.17959377
24Arginine and proline metabolism_Homo sapiens_hsa003301.14059807
25Type II diabetes mellitus_Homo sapiens_hsa049301.13064461
26Fatty acid metabolism_Homo sapiens_hsa012121.11102822
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09216850
28Salivary secretion_Homo sapiens_hsa049701.07369240
29Selenocompound metabolism_Homo sapiens_hsa004501.05458915
30Nitrogen metabolism_Homo sapiens_hsa009101.04277213
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03748550
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03470654
33Oocyte meiosis_Homo sapiens_hsa041141.02188738
34Calcium signaling pathway_Homo sapiens_hsa040201.01835837
35Circadian entrainment_Homo sapiens_hsa047130.99646986
36Synaptic vesicle cycle_Homo sapiens_hsa047210.99283308
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96942292
38Phenylalanine metabolism_Homo sapiens_hsa003600.95655567
39Linoleic acid metabolism_Homo sapiens_hsa005910.93547931
40Glutamatergic synapse_Homo sapiens_hsa047240.90002709
41Fat digestion and absorption_Homo sapiens_hsa049750.89717385
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89494913
43cAMP signaling pathway_Homo sapiens_hsa040240.85245423
44GABAergic synapse_Homo sapiens_hsa047270.83593284
45Huntingtons disease_Homo sapiens_hsa050160.79320353
46Glycerolipid metabolism_Homo sapiens_hsa005610.76104506
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75727910
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75466290
49Purine metabolism_Homo sapiens_hsa002300.73826871
50Retinol metabolism_Homo sapiens_hsa008300.73112290
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71905819
52Insulin secretion_Homo sapiens_hsa049110.70955477
53Regulation of autophagy_Homo sapiens_hsa041400.70748656
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69680510
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69117083
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.68660020
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65759147
58Asthma_Homo sapiens_hsa053100.62591296
59Endocytosis_Homo sapiens_hsa041440.61390819
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60027181
61Serotonergic synapse_Homo sapiens_hsa047260.59758431
62ABC transporters_Homo sapiens_hsa020100.59165640
63Propanoate metabolism_Homo sapiens_hsa006400.58894456
64Peroxisome_Homo sapiens_hsa041460.57862196
65Hedgehog signaling pathway_Homo sapiens_hsa043400.57022537
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56660494
67Cholinergic synapse_Homo sapiens_hsa047250.55546556
68Inositol phosphate metabolism_Homo sapiens_hsa005620.53935798
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53291946
70mRNA surveillance pathway_Homo sapiens_hsa030150.52191350
71Arginine biosynthesis_Homo sapiens_hsa002200.47293659
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47201831
73Gastric acid secretion_Homo sapiens_hsa049710.46323255
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45585846
75PPAR signaling pathway_Homo sapiens_hsa033200.45139495
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44487596
77Tyrosine metabolism_Homo sapiens_hsa003500.44373702
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.43604235
79Oxytocin signaling pathway_Homo sapiens_hsa049210.43314137
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42706633
81Renin secretion_Homo sapiens_hsa049240.42488102
82RNA degradation_Homo sapiens_hsa030180.41392642
83Caffeine metabolism_Homo sapiens_hsa002320.40518741
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.38416363
85Protein digestion and absorption_Homo sapiens_hsa049740.37696302
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36641977
87Homologous recombination_Homo sapiens_hsa034400.36540086
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.34140108
89Metabolic pathways_Homo sapiens_hsa011000.33771576
90MAPK signaling pathway_Homo sapiens_hsa040100.33417466
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.33216883
92Influenza A_Homo sapiens_hsa051640.31698799
93Amphetamine addiction_Homo sapiens_hsa050310.31234556
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30913054
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30213453
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23228555
97Circadian rhythm_Homo sapiens_hsa047100.23042804
98Bile secretion_Homo sapiens_hsa049760.22550348
99Long-term potentiation_Homo sapiens_hsa047200.22231136
100Tryptophan metabolism_Homo sapiens_hsa003800.22214227

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