NPIPB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.97974174
2chromosome condensation (GO:0030261)8.81201327
3sperm capacitation (GO:0048240)8.73121495
4DNA packaging (GO:0006323)8.44388534
5plasma membrane fusion (GO:0045026)8.24383603
6single strand break repair (GO:0000012)8.04636113
7microtubule depolymerization (GO:0007019)7.52785088
8spermatid development (GO:0007286)7.44492676
9sperm-egg recognition (GO:0035036)7.40247123
10multicellular organism reproduction (GO:0032504)7.24344179
11spermatid nucleus differentiation (GO:0007289)7.23684858
12protein targeting to Golgi (GO:0000042)7.11826660
13rRNA methylation (GO:0031167)7.03189221
14establishment of protein localization to Golgi (GO:0072600)6.86511528
15binding of sperm to zona pellucida (GO:0007339)6.70358711
16reproduction (GO:0000003)6.68551150
17protein polyglutamylation (GO:0018095)6.60872623
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.57465255
19calcium ion-dependent exocytosis (GO:0017156)6.52496681
20microtubule polymerization or depolymerization (GO:0031109)6.21416775
21sexual reproduction (GO:0019953)6.11036896
22cell-cell recognition (GO:0009988)6.07803959
23rRNA modification (GO:0000154)6.03388748
24negative regulation of inclusion body assembly (GO:0090084)5.95563822
25spermatogenesis (GO:0007283)5.90325518
26male gamete generation (GO:0048232)5.88620320
27axonemal dynein complex assembly (GO:0070286)5.79254206
28gamete generation (GO:0007276)5.42767985
29cellular ketone body metabolic process (GO:0046950)5.36380954
30RNA destabilization (GO:0050779)5.34209885
31protein localization to Golgi apparatus (GO:0034067)5.28243740
32phosphatidylethanolamine biosynthetic process (GO:0006646)5.28025081
33phosphatidylethanolamine metabolic process (GO:0046337)5.04441578
34regulation of cilium movement (GO:0003352)4.87161557
35single fertilization (GO:0007338)4.86243689
36centriole replication (GO:0007099)4.83895506
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83450321
38ketone body metabolic process (GO:1902224)4.71413418
39chromatin silencing (GO:0006342)4.67113289
40motile cilium assembly (GO:0044458)4.66161517
41microtubule severing (GO:0051013)4.63095423
42regulation of Rab GTPase activity (GO:0032313)4.56235387
43positive regulation of Rab GTPase activity (GO:0032851)4.56235387
44seminiferous tubule development (GO:0072520)4.47631339
45regulation of inclusion body assembly (GO:0090083)4.34255298
46germ cell development (GO:0007281)4.29931530
47multicellular organismal reproductive process (GO:0048609)4.29211603
48centriole assembly (GO:0098534)4.25263784
49cilium or flagellum-dependent cell motility (GO:0001539)4.24510217
50regulation of centriole replication (GO:0046599)4.17876538
51fertilization (GO:0009566)4.08481339
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.07968670
53regulation of transcription involved in cell fate commitment (GO:0060850)4.05861413
54coenzyme catabolic process (GO:0009109)4.05361849
55epithelial cilium movement (GO:0003351)3.92237797
56cell wall macromolecule catabolic process (GO:0016998)3.87398115
57glycerol ether metabolic process (GO:0006662)3.83510338
58negative regulation of Rho protein signal transduction (GO:0035024)3.81587658
59cell wall macromolecule metabolic process (GO:0044036)3.61877094
60regulation of microtubule-based movement (GO:0060632)3.57997882
61ether metabolic process (GO:0018904)3.54681672
62multicellular organismal movement (GO:0050879)3.48290297
63musculoskeletal movement (GO:0050881)3.48290297
64nucleus organization (GO:0006997)3.48006787
65organic cation transport (GO:0015695)3.44531774
66cilium movement (GO:0003341)3.43965555
67male meiosis I (GO:0007141)3.42347577
68glomerular visceral epithelial cell development (GO:0072015)3.36856918
69response to acidic pH (GO:0010447)3.33786339
70mesenchymal cell differentiation involved in renal system development (GO:2001012)3.32193358
71mesenchymal cell differentiation involved in kidney development (GO:0072161)3.32193358
72piRNA metabolic process (GO:0034587)3.30159399
73cerebral cortex neuron differentiation (GO:0021895)3.25813437
74glomerular epithelial cell development (GO:0072310)3.22550579
75negative regulation of gene expression, epigenetic (GO:0045814)3.19309689
76microtubule nucleation (GO:0007020)3.13656078
77cell recognition (GO:0008037)3.13204128
78DNA methylation involved in gamete generation (GO:0043046)3.12413033
79histone H3-K9 demethylation (GO:0033169)3.11431704
80male meiosis (GO:0007140)3.03939757
81cell differentiation involved in metanephros development (GO:0072202)3.03654654
82cellular response to pH (GO:0071467)3.02090788
83cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94866041
84peptidyl-proline hydroxylation (GO:0019511)2.93955472
85multicellular organismal development (GO:0007275)2.85395507
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82297255
87mitotic G1 DNA damage checkpoint (GO:0031571)2.77778723
88polyamine biosynthetic process (GO:0006596)2.71395263
89protein-DNA complex disassembly (GO:0032986)2.71212173
90nucleosome disassembly (GO:0006337)2.71212173
91protein depolymerization (GO:0051261)2.70426290
92axoneme assembly (GO:0035082)2.67991321
93intra-Golgi vesicle-mediated transport (GO:0006891)2.65183392
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63895591
95spinal cord motor neuron differentiation (GO:0021522)2.63064193
96regulation of somitogenesis (GO:0014807)2.60677813
97receptor recycling (GO:0001881)2.59399016
98acrosome reaction (GO:0007340)11.4739848
99sperm motility (GO:0030317)11.0552662
100fusion of sperm to egg plasma membrane (GO:0007342)10.8029793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.76403040
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88739048
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.64901053
4EZH2_22144423_ChIP-Seq_EOC_Human2.42792584
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41180075
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16563568
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.16563568
8ERA_21632823_ChIP-Seq_H3396_Human2.13044734
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11752652
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05449867
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99404474
12CBP_20019798_ChIP-Seq_JUKART_Human1.95685783
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.95685783
14EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.87042428
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.85658214
16RAC3_21632823_ChIP-Seq_H3396_Human1.84394800
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.82323754
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79536491
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78759237
20DROSHA_22980978_ChIP-Seq_HELA_Human1.76791303
21CTCF_27219007_Chip-Seq_Bcells_Human1.76084874
22FUS_26573619_Chip-Seq_HEK293_Human1.75902981
23NANOG_20526341_ChIP-Seq_ESCs_Human1.74936562
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.74732406
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70532935
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70302515
27MYC_19829295_ChIP-Seq_ESCs_Human1.66182971
28TDRD3_21172665_ChIP-Seq_MCF-7_Human1.62029400
29BCL6_27268052_Chip-Seq_Bcells_Human1.60503655
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.60177012
31ZNF274_21170338_ChIP-Seq_K562_Hela1.59442333
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.57220479
33E2F1_20622854_ChIP-Seq_HELA_Human1.57069265
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.56170186
35TAF2_19829295_ChIP-Seq_ESCs_Human1.52411726
36OCT4_20526341_ChIP-Seq_ESCs_Human1.52263053
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52240523
38PHF8_20622854_ChIP-Seq_HELA_Human1.51172105
39P68_20966046_ChIP-Seq_HELA_Human1.49844588
40SMAD4_21741376_ChIP-Seq_EPCs_Human1.49492345
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48303914
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46402425
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46186329
44ER_23166858_ChIP-Seq_MCF-7_Human1.44589788
45CTCF_20526341_ChIP-Seq_ESCs_Human1.44209723
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43314535
47AR_25329375_ChIP-Seq_VCAP_Human1.42922987
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.39946632
49SMC4_20622854_ChIP-Seq_HELA_Human1.38858335
50BCOR_27268052_Chip-Seq_Bcells_Human1.37211373
51RBPJ_21746931_ChIP-Seq_IB4_Human1.36205388
52ETV1_20927104_ChIP-Seq_GIST48_Human1.34958723
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.34610655
54TP63_22573176_ChIP-Seq_HFKS_Human1.32719341
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32406815
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30696764
57REST_21632747_ChIP-Seq_MESCs_Mouse1.30621097
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.28769333
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27894722
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27724301
61P300_19829295_ChIP-Seq_ESCs_Human1.27611717
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27318408
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.27097926
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.26905066
65VDR_22108803_ChIP-Seq_LS180_Human1.24916090
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23854147
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.21450627
68TBL1_22424771_ChIP-Seq_293T_Human1.21433707
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.20879486
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20800436
71NFYB_21822215_ChIP-Seq_K562_Human1.20613841
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20377963
73TAF15_26573619_Chip-Seq_HEK293_Human1.20250437
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.19129728
75P300_27268052_Chip-Seq_Bcells_Human1.17906250
76RUNX2_22187159_ChIP-Seq_PCA_Human1.14728974
77SA1_27219007_Chip-Seq_Bcells_Human1.14545665
78PHF8_20622853_ChIP-Seq_HELA_Human1.14499258
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14044652
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12211447
81P53_21459846_ChIP-Seq_SAOS-2_Human1.11187401
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.10066190
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10038723
84NCOR_22424771_ChIP-Seq_293T_Human1.08743989
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08627410
86CEBPB_22108803_ChIP-Seq_LS180_Human1.08459462
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.07811996
88HOXB7_26014856_ChIP-Seq_BT474_Human1.07409262
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.07224679
90SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06483905
91TP53_18474530_ChIP-ChIP_U2OS_Human1.05934293
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05149558
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04460263
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03730730
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02752994
96NFYA_21822215_ChIP-Seq_K562_Human1.02713060
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02554841
98LXR_22292898_ChIP-Seq_THP-1_Human1.01414250
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00148881
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99901221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.55057390
2MP0005377_hearing/vestibular/ear_phenot4.55057390
3MP0003698_abnormal_male_reproductive4.14406951
4MP0005670_abnormal_white_adipose3.84745867
5MP0001348_abnormal_lacrimal_gland3.61020519
6MP0001929_abnormal_gametogenesis3.56008253
7MP0005423_abnormal_somatic_nervous3.19165923
8MP0003011_delayed_dark_adaptation2.37651016
9MP0002161_abnormal_fertility/fecundity2.29269804
10MP0005379_endocrine/exocrine_gland_phen2.28374157
11MP0003718_maternal_effect2.14256815
12MP0000678_abnormal_parathyroid_gland2.13522561
13MP0003646_muscle_fatigue2.05505098
14MP0005410_abnormal_fertilization10.8808858
15MP0004859_abnormal_synaptic_plasticity1.98666310
16MP0002210_abnormal_sex_determination1.73995018
17MP0002132_abnormal_respiratory_system1.64552902
18MP0002735_abnormal_chemical_nociception1.63728391
19MP0008877_abnormal_DNA_methylation1.60222029
20MP0001486_abnormal_startle_reflex1.58666482
21MP0001968_abnormal_touch/_nociception1.57574626
22MP0003879_abnormal_hair_cell1.52461884
23MP0001485_abnormal_pinna_reflex1.50286833
24MP0004510_myositis1.45108322
25MP0001145_abnormal_male_reproductive1.40953005
26MP0005310_abnormal_salivary_gland1.38202837
27MP0002234_abnormal_pharynx_morphology1.36620103
28MP0004742_abnormal_vestibular_system1.34070490
29MP0000653_abnormal_sex_gland1.31114982
30MP0005551_abnormal_eye_electrophysiolog1.29591348
31MP0002249_abnormal_larynx_morphology1.25496802
32MP0002282_abnormal_trachea_morphology1.24854173
33MP0002733_abnormal_thermal_nociception1.19488381
34MP0001905_abnormal_dopamine_level1.13670764
35MP0001765_abnormal_ion_homeostasis1.13433497
36MP0001963_abnormal_hearing_physiology1.11565060
37MP0002653_abnormal_ependyma_morphology1.11364969
38MP0000026_abnormal_inner_ear1.08334743
39MP0009053_abnormal_anal_canal1.08108356
40MP0002272_abnormal_nervous_system1.06891995
41MP0002572_abnormal_emotion/affect_behav1.06561613
42MP0000955_abnormal_spinal_cord1.04504840
43MP0002127_abnormal_cardiovascular_syste1.02570977
44MP0002138_abnormal_hepatobiliary_system1.02111629
45MP0002229_neurodegeneration1.02040508
46MP0006292_abnormal_olfactory_placode0.97967941
47MP0001984_abnormal_olfaction0.97946999
48MP0002557_abnormal_social/conspecific_i0.97682055
49MP0002928_abnormal_bile_duct0.97560993
50MP0002067_abnormal_sensory_capabilities0.96475075
51MP0005084_abnormal_gallbladder_morpholo0.96265970
52MP0001970_abnormal_pain_threshold0.95524942
53MP0002734_abnormal_mechanical_nocicepti0.94027778
54MP0009745_abnormal_behavioral_response0.93047718
55MP0005645_abnormal_hypothalamus_physiol0.87012224
56MP0008789_abnormal_olfactory_epithelium0.84127900
57MP0006276_abnormal_autonomic_nervous0.82414511
58MP0001440_abnormal_grooming_behavior0.81989831
59MP0005395_other_phenotype0.81632165
60MP0000049_abnormal_middle_ear0.81602362
61MP0005248_abnormal_Harderian_gland0.80676511
62MP0000534_abnormal_ureter_morphology0.80155620
63MP0003635_abnormal_synaptic_transmissio0.79610184
64MP0001986_abnormal_taste_sensitivity0.77915808
65MP0003880_abnormal_central_pattern0.77706800
66MP0002822_catalepsy0.76076097
67MP0009115_abnormal_fat_cell0.73167972
68MP0005253_abnormal_eye_physiology0.71358153
69MP0000516_abnormal_urinary_system0.71103903
70MP0005367_renal/urinary_system_phenotyp0.71103903
71MP0000681_abnormal_thyroid_gland0.69427206
72MP0004085_abnormal_heartbeat0.68810164
73MP0005394_taste/olfaction_phenotype0.68190641
74MP0005499_abnormal_olfactory_system0.68190641
75MP0008569_lethality_at_weaning0.66358308
76MP0009046_muscle_twitch0.65546359
77MP0005647_abnormal_sex_gland0.64404010
78MP0002063_abnormal_learning/memory/cond0.62297602
79MP0008995_early_reproductive_senescence0.62020432
80MP0005636_abnormal_mineral_homeostasis0.61487756
81MP0003119_abnormal_digestive_system0.61257979
82MP0002882_abnormal_neuron_morphology0.60489806
83MP0005535_abnormal_body_temperature0.57725123
84MP0004133_heterotaxia0.55435114
85MP0001879_abnormal_lymphatic_vessel0.54249235
86MP0001501_abnormal_sleep_pattern0.54219864
87MP0003787_abnormal_imprinting0.54116718
88MP0005167_abnormal_blood-brain_barrier0.53827917
89MP0000470_abnormal_stomach_morphology0.52129504
90MP0002752_abnormal_somatic_nervous0.52086985
91MP0002064_seizures0.50416528
92MP0000230_abnormal_systemic_arterial0.50087739
93MP0003121_genomic_imprinting0.48582840
94MP0004270_analgesia0.48307368
95MP0004484_altered_response_of0.47055533
96MP0002160_abnormal_reproductive_system0.46636585
97MP0001666_abnormal_nutrient_absorption0.45223393
98MP0001293_anophthalmia0.45148871
99MP0005451_abnormal_body_composition0.44327432
100MP0003137_abnormal_impulse_conducting0.42666398

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.89215464
2Absent/shortened dynein arms (HP:0200106)6.28806672
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.28806672
4Bony spicule pigmentary retinopathy (HP:0007737)4.94883771
5Abnormal ciliary motility (HP:0012262)4.80443891
6Attenuation of retinal blood vessels (HP:0007843)4.74567100
7Abnormal respiratory motile cilium physiology (HP:0012261)4.60898553
8Abnormal respiratory motile cilium morphology (HP:0005938)4.55828220
9Abnormal respiratory epithelium morphology (HP:0012253)4.55828220
10Chronic hepatic failure (HP:0100626)4.53380189
11Asymmetric septal hypertrophy (HP:0001670)4.53240640
12Abnormal rod and cone electroretinograms (HP:0008323)4.52564439
13Male infertility (HP:0003251)4.37226345
14Tubulointerstitial nephritis (HP:0001970)4.21996794
15Infertility (HP:0000789)4.15993469
16Resting tremor (HP:0002322)4.02762161
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.97115357
18Abnormality of macular pigmentation (HP:0008002)3.91618266
19Nasal polyposis (HP:0100582)3.80680646
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.80594812
21Double outlet right ventricle (HP:0001719)3.54604433
22Congenital malformation of the right heart (HP:0011723)3.54604433
23Facial shape deformation (HP:0011334)3.51113345
24Potter facies (HP:0002009)3.51113345
25Hyperkalemia (HP:0002153)3.45191138
26Bell-shaped thorax (HP:0001591)3.42037554
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.33986948
28Hypoplastic ischia (HP:0003175)3.30206078
29Enlarged epiphyses (HP:0010580)3.22937675
30Azoospermia (HP:0000027)3.21250847
31Abnormality of the aortic arch (HP:0012303)3.12581469
32Myokymia (HP:0002411)3.08045304
33Abnormal spermatogenesis (HP:0008669)3.06901360
34Nephronophthisis (HP:0000090)3.01597570
35Abnormality of the nasal mucosa (HP:0000433)2.98019220
36Cone-rod dystrophy (HP:0000548)2.92887189
37Postural instability (HP:0002172)2.89760486
38Renal dysplasia (HP:0000110)2.87807403
39Abnormal urine output (HP:0012590)2.81888600
40Abnormality of the ischium (HP:0003174)2.81652134
41Hypoplasia of the thymus (HP:0000778)2.80756660
42Unilateral renal agenesis (HP:0000122)2.79934969
43Impulsivity (HP:0100710)2.76753441
44Rhinitis (HP:0012384)2.72389022
45Stage 5 chronic kidney disease (HP:0003774)2.71439030
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67355504
47Polydipsia (HP:0001959)2.65532940
48Abnormal drinking behavior (HP:0030082)2.65532940
49Abnormality of the renal medulla (HP:0100957)2.57375680
50Progressive cerebellar ataxia (HP:0002073)2.56004631
51Truncal obesity (HP:0001956)2.55214364
52Abnormality of dental color (HP:0011073)2.54639677
53Abnormality of renal excretion (HP:0011036)2.54224616
54Osteomalacia (HP:0002749)2.51648727
55Progressive sensorineural hearing impairment (HP:0000408)2.50119675
56Amelogenesis imperfecta (HP:0000705)2.47495677
57Polyuria (HP:0000103)2.44038434
58Intellectual disability, moderate (HP:0002342)2.38784658
59Hyperthyroidism (HP:0000836)2.33552127
60Generalized aminoaciduria (HP:0002909)2.31401795
61Fetal akinesia sequence (HP:0001989)2.27343939
62Abnormality of the parathyroid morphology (HP:0011766)2.24335585
63Tubulointerstitial abnormality (HP:0001969)2.23285135
64Abnormality of potassium homeostasis (HP:0011042)2.17278650
65Insulin-resistant diabetes mellitus (HP:0000831)2.14250385
66Portal hypertension (HP:0001409)2.08977681
67Glycosuria (HP:0003076)2.08805440
68Abnormality of urine glucose concentration (HP:0011016)2.08805440
69Muscle fiber atrophy (HP:0100295)2.05836635
70Renal Fanconi syndrome (HP:0001994)2.03089985
71Bronchiectasis (HP:0002110)2.01770584
72Decreased central vision (HP:0007663)2.01425586
73Pendular nystagmus (HP:0012043)1.96991776
74Tetany (HP:0001281)1.94637864
75Abnormality of the costochondral junction (HP:0000919)1.91686835
76Abnormality of the hepatic vasculature (HP:0006707)1.91363712
77Esotropia (HP:0000565)1.89148304
78Sensory axonal neuropathy (HP:0003390)1.87425403
79Focal segmental glomerulosclerosis (HP:0000097)1.86503147
80Hypoalphalipoproteinemia (HP:0003233)1.86236177
81Retinal atrophy (HP:0001105)1.86220215
82Hypophosphatemic rickets (HP:0004912)1.85673106
83Amblyopia (HP:0000646)1.84135000
84Tubular atrophy (HP:0000092)1.83637677
85Renovascular hypertension (HP:0100817)1.83235276
86Congenital stationary night blindness (HP:0007642)1.82271314
87Menstrual irregularities (HP:0000858)1.81156517
88Chronic bronchitis (HP:0004469)1.80601509
89Truncus arteriosus (HP:0001660)1.79531141
90Type 2 muscle fiber atrophy (HP:0003554)1.78684787
91Recurrent corneal erosions (HP:0000495)1.78308336
92Pancreatic fibrosis (HP:0100732)1.78274875
93Hyponatremia (HP:0002902)1.78030936
94Optic nerve hypoplasia (HP:0000609)1.77568213
95Epiphyseal dysplasia (HP:0002656)1.74053131
96Failure to thrive in infancy (HP:0001531)1.73245467
97Photophobia (HP:0000613)1.72995314
98Abnormal ventriculo-arterial connection (HP:0011563)1.72703720
99Transposition of the great arteries (HP:0001669)1.72703720
100Abnormal connection of the cardiac segments (HP:0011545)1.72703720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.88861477
2TESK15.08001030
3DDR24.23258539
4INSRR4.22399033
5MAP4K23.66519878
6PNCK3.10819867
7PLK22.90684767
8PRKD32.65412976
9STK382.62282130
10BRD42.61723826
11PRPF4B2.52383912
12CAMK1G2.24692937
13MAPK152.03043830
14TAOK21.76765557
15STK38L1.73410392
16WNK11.72483536
17PDPK11.57659591
18MAP3K91.51094603
19PDK11.46510784
20MARK11.43031017
21PIK3CG1.40311057
22CDK191.38188913
23OXSR11.23051760
24TYRO31.12924827
25DYRK1B1.11490258
26CDK71.06650812
27PINK11.01448273
28PTK2B1.00635103
29RPS6KA20.99209007
30MST1R0.95264730
31CAMK1D0.93238038
32BMPR1B0.89849561
33NEK60.85731121
34SIK20.81787851
35SGK4940.80584867
36SGK2230.80584867
37PRKCG0.80526693
38WNK40.77834667
39CDK120.77732688
40FRK0.77470108
41KSR20.71157092
42PRKG10.69868451
43UHMK10.69411565
44NTRK30.66182641
45CAMK10.66039235
46PRKAA20.65785083
47RPS6KA10.63559849
48PRKG20.61265485
49DYRK20.60936480
50PKN10.60631196
51STK390.57600973
52LATS20.53906533
53TIE10.51174519
54PRKCZ0.51143999
55ABL20.48992840
56MUSK0.48506403
57MAPK130.47581977
58MAP3K110.47576059
59BRAF0.46958435
60SGK10.46474356
61CDK30.44336995
62MAP3K40.44323507
63CAMK40.44030665
64GSK3B0.42728390
65MAPK10.42103173
66AKT30.41730180
67MAP2K20.40484297
68GRK10.39083583
69ADRBK20.37717042
70RPS6KA60.37044061
71CDK20.36873547
72RPS6KL10.36292508
73RPS6KC10.36292508
74CDK10.35866102
75DYRK30.35765783
76PRKCH0.35664349
77MARK20.35042425
78WNK30.34955515
79PRKAA10.33278546
80CASK0.30056793
81PHKG20.29786833
82PHKG10.29786833
83MAP3K80.29288089
84CHEK10.27645034
85ROCK10.26980415
86MAPK80.25617836
87SGK20.24488846
88MAPK140.24486017
89MAP3K20.22745133
90FGFR20.22645162
91PRKCE0.22321130
92PRKCB0.22310268
93AKT10.21771499
94MINK10.21232097
95ZAK0.21185205
96STK110.20766819
97PRKACA0.19980343
98CDK80.18040383
99CSNK1A10.17600098
100CDK40.16071053

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.64171563
2Fatty acid biosynthesis_Homo sapiens_hsa000615.66002421
3Olfactory transduction_Homo sapiens_hsa047403.67955565
4Butanoate metabolism_Homo sapiens_hsa006502.89548092
5Dorso-ventral axis formation_Homo sapiens_hsa043202.03299923
6Phototransduction_Homo sapiens_hsa047442.02750342
7Taste transduction_Homo sapiens_hsa047421.95967261
8Glycerophospholipid metabolism_Homo sapiens_hsa005641.94132203
9Type I diabetes mellitus_Homo sapiens_hsa049401.89446707
10Allograft rejection_Homo sapiens_hsa053301.60818000
11Cardiac muscle contraction_Homo sapiens_hsa042601.59612218
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59127231
13Autoimmune thyroid disease_Homo sapiens_hsa053201.58254380
14Fatty acid metabolism_Homo sapiens_hsa012121.51920007
15Fatty acid degradation_Homo sapiens_hsa000711.49466393
16RNA transport_Homo sapiens_hsa030131.48860228
17Graft-versus-host disease_Homo sapiens_hsa053321.45465073
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44487459
19Phenylalanine metabolism_Homo sapiens_hsa003601.39902809
20Antigen processing and presentation_Homo sapiens_hsa046121.37703243
21Type II diabetes mellitus_Homo sapiens_hsa049301.32632089
22Synaptic vesicle cycle_Homo sapiens_hsa047211.26625977
23Nicotine addiction_Homo sapiens_hsa050331.20962957
24Arginine and proline metabolism_Homo sapiens_hsa003301.20762557
25Bile secretion_Homo sapiens_hsa049761.16130356
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13252948
27Endocytosis_Homo sapiens_hsa041441.12277201
28Inositol phosphate metabolism_Homo sapiens_hsa005621.11047520
29Insulin secretion_Homo sapiens_hsa049111.10081338
30Morphine addiction_Homo sapiens_hsa050321.06045157
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05149958
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01862437
33Salivary secretion_Homo sapiens_hsa049700.95824480
34Primary bile acid biosynthesis_Homo sapiens_hsa001200.93037981
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92859621
36Protein digestion and absorption_Homo sapiens_hsa049740.92746331
37Glutamatergic synapse_Homo sapiens_hsa047240.92681408
38cAMP signaling pathway_Homo sapiens_hsa040240.91690904
39Viral myocarditis_Homo sapiens_hsa054160.90723243
40Sulfur relay system_Homo sapiens_hsa041220.87624497
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87295760
42Arginine biosynthesis_Homo sapiens_hsa002200.85634702
43Oocyte meiosis_Homo sapiens_hsa041140.85124862
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84061214
45ABC transporters_Homo sapiens_hsa020100.83310178
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.82056174
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81316382
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.79612839
49Circadian entrainment_Homo sapiens_hsa047130.78843817
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77005198
51Fat digestion and absorption_Homo sapiens_hsa049750.76433532
52Calcium signaling pathway_Homo sapiens_hsa040200.75937245
53GABAergic synapse_Homo sapiens_hsa047270.75143189
54Glycerolipid metabolism_Homo sapiens_hsa005610.73724686
55Hedgehog signaling pathway_Homo sapiens_hsa043400.70981549
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70611802
57Basal transcription factors_Homo sapiens_hsa030220.70082900
58Retinol metabolism_Homo sapiens_hsa008300.67779411
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64039388
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63821306
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62850775
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59861270
63Tyrosine metabolism_Homo sapiens_hsa003500.57379052
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57310893
65Selenocompound metabolism_Homo sapiens_hsa004500.56751956
66MAPK signaling pathway_Homo sapiens_hsa040100.54839327
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54828962
68PPAR signaling pathway_Homo sapiens_hsa033200.53973416
69Peroxisome_Homo sapiens_hsa041460.52735584
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.50839126
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50415175
72Renin secretion_Homo sapiens_hsa049240.49788963
73Huntingtons disease_Homo sapiens_hsa050160.48346593
74Renin-angiotensin system_Homo sapiens_hsa046140.48001245
75Cholinergic synapse_Homo sapiens_hsa047250.46037330
76Serotonergic synapse_Homo sapiens_hsa047260.45529032
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45429065
78Influenza A_Homo sapiens_hsa051640.44331578
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44283949
80Linoleic acid metabolism_Homo sapiens_hsa005910.39557164
81Gastric acid secretion_Homo sapiens_hsa049710.39150896
82Oxytocin signaling pathway_Homo sapiens_hsa049210.38426137
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.38037148
84mRNA surveillance pathway_Homo sapiens_hsa030150.37428165
85Estrogen signaling pathway_Homo sapiens_hsa049150.36134199
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35974641
87Chemical carcinogenesis_Homo sapiens_hsa052040.35141738
88Dopaminergic synapse_Homo sapiens_hsa047280.34859209
89Pancreatic secretion_Homo sapiens_hsa049720.34766206
90Purine metabolism_Homo sapiens_hsa002300.34156922
91Nitrogen metabolism_Homo sapiens_hsa009100.34111955
92Vitamin B6 metabolism_Homo sapiens_hsa007500.33678698
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33366101
94Regulation of autophagy_Homo sapiens_hsa041400.29853577
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27417071
96Metabolic pathways_Homo sapiens_hsa011000.26564626
97VEGF signaling pathway_Homo sapiens_hsa043700.24818280
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24280725
99Tight junction_Homo sapiens_hsa045300.23528985
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23458529

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