ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.84813404
2	acrosome reaction (GO:0007340)	7.45633901
3	sphingosine metabolic process (GO:0006670)	6.61926332
4	response to pheromone (GO:0019236)	6.51068875
5	DNA methylation involved in gamete generation (GO:0043046)	6.34753427
6	spermatid development (GO:0007286)	6.34603417
7	diol metabolic process (GO:0034311)	6.11683795
8	regulation of cilium movement (GO:0003352)	5.86467402
9	regulation of meiosis I (GO:0060631)	5.82080619
10	fusion of sperm to egg plasma membrane (GO:0007342)	5.75469079
11	sphingoid metabolic process (GO:0046519)	5.60223608
12	piRNA metabolic process (GO:0034587)	5.57189201
13	multicellular organism reproduction (GO:0032504)	5.40396724
14	phosphatidylethanolamine metabolic process (GO:0046337)	5.24506994
15	protein polyglutamylation (GO:0018095)	5.12516784
16	sperm capacitation (GO:0048240)	5.08030632
17	centriole replication (GO:0007099)	5.05780716
18	DNA packaging (GO:0006323)	5.01096770
19	chromosome condensation (GO:0030261)	4.95227168
20	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.94848517
21	sperm-egg recognition (GO:0035036)	4.90901591
22	protein targeting to Golgi (GO:0000042)	4.89891247
23	axonemal dynein complex assembly (GO:0070286)	4.89808453
24	establishment of protein localization to Golgi (GO:0072600)	4.83310154
25	regulation of microtubule-based movement (GO:0060632)	4.74553542
26	protein-chromophore linkage (GO:0018298)	4.60759016
27	reproduction (GO:0000003)	4.52384217
28	somite rostral/caudal axis specification (GO:0032525)	4.46422655
29	microtubule depolymerization (GO:0007019)	4.46378868
30	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.45838919
31	single strand break repair (GO:0000012)	4.45426389
32	plasma membrane fusion (GO:0045026)	4.29672002
33	calcium ion-dependent exocytosis (GO:0017156)	4.21730427
34	organic cation transport (GO:0015695)	4.19755189
35	spermatogenesis (GO:0007283)	4.17966174
36	male gamete generation (GO:0048232)	4.17577186
37	epithelial cilium movement (GO:0003351)	4.17037203
38	tachykinin receptor signaling pathway (GO:0007217)	4.11933051
39	spermatid nucleus differentiation (GO:0007289)	4.09224743
40	cellular ketone body metabolic process (GO:0046950)	4.00170850
41	cell-cell recognition (GO:0009988)	3.98975967
42	single fertilization (GO:0007338)	3.97699921
43	binding of sperm to zona pellucida (GO:0007339)	3.95148320
44	rRNA methylation (GO:0031167)	3.94834702
45	regulation of protein glycosylation (GO:0060049)	3.93367642
46	centriole assembly (GO:0098534)	3.92173561
47	microtubule severing (GO:0051013)	3.90184892
48	microtubule polymerization or depolymerization (GO:0031109)	3.82331664
49	ketone body metabolic process (GO:1902224)	3.81994353
50	gamete generation (GO:0007276)	3.80825844
51	coenzyme catabolic process (GO:0009109)	3.73073226
52	cilium or flagellum-dependent cell motility (GO:0001539)	3.70327979
53	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.70326384
54	axoneme assembly (GO:0035082)	3.69801363
55	protein localization to Golgi apparatus (GO:0034067)	3.64263952
56	germ cell development (GO:0007281)	3.59868262
57	meiotic chromosome segregation (GO:0045132)	3.53908392
58	cilium movement (GO:0003341)	3.42920730
59	positive regulation of developmental pigmentation (GO:0048087)	3.33124480
60	rRNA modification (GO:0000154)	3.30431188
61	nonmotile primary cilium assembly (GO:0035058)	3.28045636
62	fertilization (GO:0009566)	3.25393054
63	regulation of somitogenesis (GO:0014807)	3.21275896
64	lipopolysaccharide biosynthetic process (GO:0009103)	3.20518647
65	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.19238339
66	polyamine metabolic process (GO:0006595)	3.17070712
67	sulfate transport (GO:0008272)	3.16506466
68	sulfate transmembrane transport (GO:1902358)	3.15298143
69	mitochondrial fission (GO:0000266)	3.14986266
70	male meiosis (GO:0007140)	3.12536690
71	neurofilament cytoskeleton organization (GO:0060052)	3.09654353
72	regulation of pigment cell differentiation (GO:0050932)	3.09448629
73	photoreceptor cell maintenance (GO:0045494)	3.07254644
74	cellular biogenic amine biosynthetic process (GO:0042401)	3.05731359
75	left/right axis specification (GO:0070986)	3.05328762
76	cAMP catabolic process (GO:0006198)	3.04825940
77	motile cilium assembly (GO:0044458)	3.04181229
78	polyamine biosynthetic process (GO:0006596)	3.03611348
79	amine biosynthetic process (GO:0009309)	3.01122085
80	multicellular organismal reproductive process (GO:0048609)	2.99349280
81	regulation of interleukin-5 production (GO:0032674)	2.92790519
82	positive regulation of Rab GTPase activity (GO:0032851)	2.91124212
83	regulation of Rab GTPase activity (GO:0032313)	2.91124212
84	sulfur compound transport (GO:0072348)	2.86946222
85	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.79398382
86	positive regulation of meiosis (GO:0045836)	2.77916724
87	indolalkylamine metabolic process (GO:0006586)	2.74151174
88	tyrosine metabolic process (GO:0006570)	2.70279274
89	cyclic nucleotide catabolic process (GO:0009214)	2.69049995
90	male meiosis I (GO:0007141)	2.68574983
91	lipopolysaccharide metabolic process (GO:0008653)	2.68511622
92	positive regulation of meiotic cell cycle (GO:0051446)	2.67770146
93	urate metabolic process (GO:0046415)	2.66104080
94	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.64598845
95	cellular biogenic amine catabolic process (GO:0042402)	2.64575040
96	amine catabolic process (GO:0009310)	2.64575040
97	glycerol ether metabolic process (GO:0006662)	2.62231044
98	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.61294883
99	L-phenylalanine catabolic process (GO:0006559)	2.61294883
100	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.60526463

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	2.74701504
2	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.65838159
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49544642
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48156758
5	ER_23166858_ChIP-Seq_MCF-7_Human	2.38607349
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.30431100
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.29351454
8	FUS_26573619_Chip-Seq_HEK293_Human	2.17198096
9	CBP_20019798_ChIP-Seq_JUKART_Human	2.17018962
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.17018962
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15388719
12	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.15388719
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10499128
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04066723
15	P300_19829295_ChIP-Seq_ESCs_Human	1.95428016
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95028851
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88567430
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.88083509
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.87807277
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85640272
21	SOX2_19829295_ChIP-Seq_ESCs_Human	1.83784131
22	NANOG_19829295_ChIP-Seq_ESCs_Human	1.83784131
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.79134474
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.70020826
25	OCT4_20526341_ChIP-Seq_ESCs_Human	1.67885039
26	AR_25329375_ChIP-Seq_VCAP_Human	1.66543743
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64640123
28	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.62364840
29	NANOG_20526341_ChIP-Seq_ESCs_Human	1.59992006
30	EZH2_22144423_ChIP-Seq_EOC_Human	1.57307874
31	HOXB7_26014856_ChIP-Seq_BT474_Human	1.55038457
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54764298
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54737249
34	STAT3_23295773_ChIP-Seq_U87_Human	1.52053591
35	TAF2_19829295_ChIP-Seq_ESCs_Human	1.51429869
36	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.50794290
37	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.49896035
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49502607
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49488097
40	MYC_19829295_ChIP-Seq_ESCs_Human	1.48333595
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46942462
42	RAC3_21632823_ChIP-Seq_H3396_Human	1.46922766
43	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.46213197
44	ERA_21632823_ChIP-Seq_H3396_Human	1.46009633
45	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44057804
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43715662
47	VDR_22108803_ChIP-Seq_LS180_Human	1.42715135
48	NCOR_22424771_ChIP-Seq_293T_Human	1.41346683
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39081568
50	TCF4_23295773_ChIP-Seq_U87_Human	1.39063275
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.38674269
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37702630
53	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36520080
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.36076082
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34386368
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33161995
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33100232
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33100232
59	CEBPB_22108803_ChIP-Seq_LS180_Human	1.28048799
60	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25756023
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25548061
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23432884
63	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.22506879
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22019813
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20206198
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19903830
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19848073
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17167999
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16999752
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16781645
71	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.16667024
72	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14870246
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14667177
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14160415
75	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.14081141
76	TP53_18474530_ChIP-ChIP_U2OS_Human	1.14047554
77	AR_20517297_ChIP-Seq_VCAP_Human	1.13618190
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.13459312
79	TP53_22573176_ChIP-Seq_HFKS_Human	1.12688542
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12662431
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12522940
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.11880244
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11358900
84	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11324609
85	ERG_20517297_ChIP-Seq_VCAP_Human	1.10898245
86	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.10794103
87	SMRT_27268052_Chip-Seq_Bcells_Human	1.09799831
88	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.09041427
89	TCF4_22108803_ChIP-Seq_LS180_Human	1.09001376
90	STAT1_20625510_ChIP-Seq_HELA_Human	1.07822775
91	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.04708133
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04631413
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04212981
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03558122
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01949677
96	PHF8_20622853_ChIP-Seq_HELA_Human	1.01901867
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.01254715
98	E2F1_20622854_ChIP-Seq_HELA_Human	1.01249616
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00540181
100	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00369010

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.61700551
2	MP0002837_dystrophic_cardiac_calcinosis	5.12074490
3	MP0003136_yellow_coat_color	5.00460064
4	MP0003646_muscle_fatigue	4.90957332
5	MP0005171_absent_coat_pigmentation	4.33151797
6	MP0002653_abnormal_ependyma_morphology	3.98060605
7	MP0005377_hearing/vestibular/ear_phenot	3.72400487
8	MP0003878_abnormal_ear_physiology	3.72400487
9	MP0005670_abnormal_white_adipose	3.36500262
10	MP0000569_abnormal_digit_pigmentation	2.96024560
11	MP0003045_fibrosis	2.50664014
12	MP0003698_abnormal_male_reproductive	2.40000308
13	MP0003879_abnormal_hair_cell	2.38283431
14	MP0001929_abnormal_gametogenesis	2.26734615
15	MP0003718_maternal_effect	2.17622289
16	MP0004381_abnormal_hair_follicle	2.03816067
17	MP0000015_abnormal_ear_pigmentation	1.99292777
18	MP0001984_abnormal_olfaction	1.97587980
19	MP0005075_abnormal_melanosome_morpholog	1.96776204
20	MP0002138_abnormal_hepatobiliary_system	1.80441578
21	MP0002095_abnormal_skin_pigmentation	1.77859074
22	MP0005551_abnormal_eye_electrophysiolog	1.76473183
23	MP0003890_abnormal_embryonic-extraembry	1.69639840
24	MP0005395_other_phenotype	1.55421579
25	MP0004043_abnormal_pH_regulation	1.53221945
26	MP0005174_abnormal_tail_pigmentation	1.51304578
27	MP0005085_abnormal_gallbladder_physiolo	1.35179474
28	MP0003195_calcinosis	1.34588462
29	MP0001486_abnormal_startle_reflex	1.33580262
30	MP0002161_abnormal_fertility/fecundity	1.33249609
31	MP0002735_abnormal_chemical_nociception	1.31382267
32	MP0002168_other_aberrant_phenotype	1.28721789
33	MP0001501_abnormal_sleep_pattern	1.28298635
34	MP0005253_abnormal_eye_physiology	1.26681145
35	MP0000749_muscle_degeneration	1.26472382
36	MP0001485_abnormal_pinna_reflex	1.22520539
37	MP0000372_irregular_coat_pigmentation	1.21006876
38	MP0005645_abnormal_hypothalamus_physiol	1.20244431
39	MP0002234_abnormal_pharynx_morphology	1.19704017
40	MP0002938_white_spotting	1.18150658
41	MP0001968_abnormal_touch/_nociception	1.16987942
42	MP0002160_abnormal_reproductive_system	1.16126733
43	MP0005365_abnormal_bile_salt	1.12013962
44	MP0002210_abnormal_sex_determination	1.10075220
45	MP0002272_abnormal_nervous_system	1.09843887
46	MP0002229_neurodegeneration	1.09488984
47	MP0003011_delayed_dark_adaptation	1.06906097
48	MP0008875_abnormal_xenobiotic_pharmacok	1.05104524
49	MP0004742_abnormal_vestibular_system	1.04566437
50	MP0003137_abnormal_impulse_conducting	0.98695262
51	MP0005646_abnormal_pituitary_gland	0.95258258
52	MP0002736_abnormal_nociception_after	0.95032953
53	MP0003172_abnormal_lysosome_physiology	0.94539009
54	MP0008877_abnormal_DNA_methylation	0.94210115
55	MP0005310_abnormal_salivary_gland	0.91794301
56	MP0001324_abnormal_eye_pigmentation	0.90111135
57	MP0001764_abnormal_homeostasis	0.90078558
58	MP0000427_abnormal_hair_cycle	0.88824895
59	MP0009764_decreased_sensitivity_to	0.88017710
60	MP0009115_abnormal_fat_cell	0.86243092
61	MP0001145_abnormal_male_reproductive	0.86046543
62	MP0000653_abnormal_sex_gland	0.85271661
63	MP0001963_abnormal_hearing_physiology	0.84243150
64	MP0001970_abnormal_pain_threshold	0.83247854
65	MP0002733_abnormal_thermal_nociception	0.82812664
66	MP0008872_abnormal_physiological_respon	0.82762559
67	MP0002928_abnormal_bile_duct	0.82691578
68	MP0009745_abnormal_behavioral_response	0.81308912
69	MP0002557_abnormal_social/conspecific_i	0.79790165
70	MP0003252_abnormal_bile_duct	0.77417140
71	MP0003787_abnormal_imprinting	0.76253658
72	MP0002572_abnormal_emotion/affect_behav	0.73064497
73	MP0000026_abnormal_inner_ear	0.71542070
74	MP0002876_abnormal_thyroid_physiology	0.71117050
75	MP0005319_abnormal_enzyme/_coenzyme	0.69902085
76	MP0002269_muscular_atrophy	0.69392867
77	MP0004484_altered_response_of	0.68965535
78	MP0004142_abnormal_muscle_tone	0.68295153
79	MP0006036_abnormal_mitochondrial_physio	0.66438595
80	MP0006276_abnormal_autonomic_nervous	0.64038243
81	MP0010329_abnormal_lipoprotein_level	0.63753142
82	MP0006072_abnormal_retinal_apoptosis	0.63559064
83	MP0002075_abnormal_coat/hair_pigmentati	0.63061318
84	MP0005389_reproductive_system_phenotype	0.62729646
85	MP0005379_endocrine/exocrine_gland_phen	0.57012056
86	MP0005332_abnormal_amino_acid	0.56497113
87	MP0002734_abnormal_mechanical_nocicepti	0.56194593
88	MP0001502_abnormal_circadian_rhythm	0.54578403
89	MP0002132_abnormal_respiratory_system	0.53674707
90	MP0008770_decreased_survivor_rate	0.53525127
91	MP0001905_abnormal_dopamine_level	0.52095001
92	MP0005423_abnormal_somatic_nervous	0.51705484
93	MP0002090_abnormal_vision	0.51036337
94	MP0004233_abnormal_muscle_weight	0.50562820
95	MP0003950_abnormal_plasma_membrane	0.50163411
96	MP0005535_abnormal_body_temperature	0.48416520
97	MP0001119_abnormal_female_reproductive	0.46615659
98	MP0005195_abnormal_posterior_eye	0.45333677
99	MP0008789_abnormal_olfactory_epithelium	0.42877138
100	MP0002067_abnormal_sensory_capabilities	0.42187388

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	6.31438807
2	Severe visual impairment (HP:0001141)	5.94630939
3	Chronic hepatic failure (HP:0100626)	5.43956895
4	Tubulointerstitial nephritis (HP:0001970)	4.17936221
5	Focal motor seizures (HP:0011153)	3.98656482
6	Abnormality of macular pigmentation (HP:0008002)	3.86123380
7	Parakeratosis (HP:0001036)	3.73085497
8	Pancreatic cysts (HP:0001737)	3.64639906
9	Albinism (HP:0001022)	3.64505426
10	Attenuation of retinal blood vessels (HP:0007843)	3.53663195
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.51510528
12	Absent/shortened dynein arms (HP:0200106)	3.51510528
13	Nephronophthisis (HP:0000090)	3.42209864
14	Acanthocytosis (HP:0001927)	3.38287942
15	Potter facies (HP:0002009)	3.38181596
16	Facial shape deformation (HP:0011334)	3.38181596
17	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.33435466
18	Pendular nystagmus (HP:0012043)	3.32623897
19	Abnormality of the renal medulla (HP:0100957)	3.23738698
20	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.23192020
21	Hyperkalemia (HP:0002153)	3.12007909
22	Abnormality of the renal cortex (HP:0011035)	3.01667791
23	Abnormal respiratory motile cilium physiology (HP:0012261)	2.87554641
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.84774800
25	Unilateral renal agenesis (HP:0000122)	2.81868698
26	Pancreatic fibrosis (HP:0100732)	2.74581663
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.71646507
28	Cerebellar dysplasia (HP:0007033)	2.65315806
29	Aplastic anemia (HP:0001915)	2.55480046
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.54193640
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.54193640
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.53655976
33	Abnormal ciliary motility (HP:0012262)	2.53118599
34	Tubulointerstitial abnormality (HP:0001969)	2.48751254
35	Polydipsia (HP:0001959)	2.45823106
36	Abnormal drinking behavior (HP:0030082)	2.45823106
37	Horizontal nystagmus (HP:0000666)	2.40037666
38	Portal hypertension (HP:0001409)	2.36941488
39	Stomach cancer (HP:0012126)	2.35067788
40	Tubular atrophy (HP:0000092)	2.34864494
41	Cystic liver disease (HP:0006706)	2.32038110
42	Hyperglycinemia (HP:0002154)	2.31037228
43	Dialeptic seizures (HP:0011146)	2.30784085
44	Abnormality of potassium homeostasis (HP:0011042)	2.29411858
45	True hermaphroditism (HP:0010459)	2.28385691
46	Decreased central vision (HP:0007663)	2.27846025
47	Medial flaring of the eyebrow (HP:0010747)	2.27364037
48	Colon cancer (HP:0003003)	2.27065276
49	Chronic bronchitis (HP:0004469)	2.24893814
50	Cone-rod dystrophy (HP:0000548)	2.24648933
51	Occipital encephalocele (HP:0002085)	2.20432586
52	Abnormal urine output (HP:0012590)	2.19651058
53	Proximal amyotrophy (HP:0007126)	2.16775639
54	Opisthotonus (HP:0002179)	2.16238429
55	Subcapsular cataract (HP:0000523)	2.15887389
56	Type I transferrin isoform profile (HP:0003642)	2.14976035
57	Stage 5 chronic kidney disease (HP:0003774)	2.14796299
58	Asymmetric septal hypertrophy (HP:0001670)	2.14348045
59	Congenital primary aphakia (HP:0007707)	2.13641918
60	Gait imbalance (HP:0002141)	2.13293786
61	Postural instability (HP:0002172)	2.11915478
62	Abnormality of the hepatic vasculature (HP:0006707)	2.10947506
63	Polyuria (HP:0000103)	2.09833719
64	Type II lissencephaly (HP:0007260)	2.08859866
65	Nephrogenic diabetes insipidus (HP:0009806)	2.08618827
66	Photophobia (HP:0000613)	2.06995548
67	Optic nerve hypoplasia (HP:0000609)	2.04775956
68	Congenital stationary night blindness (HP:0007642)	2.04544184
69	Genital tract atresia (HP:0001827)	2.04048683
70	Male infertility (HP:0003251)	1.98029052
71	Vaginal atresia (HP:0000148)	1.97500308
72	Infertility (HP:0000789)	1.97342131
73	Progressive cerebellar ataxia (HP:0002073)	1.92780866
74	Retinitis pigmentosa (HP:0000510)	1.92455793
75	Inability to walk (HP:0002540)	1.91896619
76	Atonic seizures (HP:0010819)	1.91563776
77	Abnormality of renal excretion (HP:0011036)	1.90638795
78	Thyroid-stimulating hormone excess (HP:0002925)	1.90428837
79	Enlarged kidneys (HP:0000105)	1.86598611
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.86420260
81	Renal Fanconi syndrome (HP:0001994)	1.85146082
82	Tetany (HP:0001281)	1.84408143
83	Poor coordination (HP:0002370)	1.84076434
84	Abnormality of midbrain morphology (HP:0002418)	1.82552115
85	Molar tooth sign on MRI (HP:0002419)	1.82552115
86	Dehydration (HP:0001944)	1.82504456
87	Difficulty walking (HP:0002355)	1.81562191
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81529283
89	Rhinitis (HP:0012384)	1.80525036
90	Hypokalemia (HP:0002900)	1.79750233
91	Resting tremor (HP:0002322)	1.79379489
92	Congenital ichthyosiform erythroderma (HP:0007431)	1.79326196
93	Abnormality of dental color (HP:0011073)	1.79271059
94	Congenital malformation of the right heart (HP:0011723)	1.76828296
95	Double outlet right ventricle (HP:0001719)	1.76828296
96	Bronchiectasis (HP:0002110)	1.76514941
97	Abnormality of urine glucose concentration (HP:0011016)	1.76037465
98	Glycosuria (HP:0003076)	1.76037465
99	Neonatal respiratory distress (HP:0002643)	1.75687130
100	Impulsivity (HP:0100710)	1.71104482

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	7.61333532
2	STK38L	5.70891811
3	LATS2	3.62584678
4	STK38	3.38954823
5	ZAK	3.14260153
6	PLK4	3.04091922
7	FRK	2.64319550
8	TESK1	2.62188187
9	BRD4	2.32799182
10	PRKD3	2.28744004
11	PDK2	2.17430403
12	MAP4K2	2.10455435
13	WNK4	1.96795163
14	PINK1	1.90454617
15	EIF2AK3	1.72454310
16	BMPR1B	1.70195338
17	MST4	1.68629598
18	MAP2K2	1.44060588
19	TAOK3	1.43581797
20	STK3	1.38833960
21	PDPK1	1.34232352
22	TXK	1.32789038
23	PLK2	1.30998676
24	ACVR1B	1.30452431
25	NEK6	1.30037997
26	INSRR	1.28782000
27	NUAK1	1.25186456
28	PIK3CG	1.18341081
29	MAPK15	1.15398268
30	PNCK	1.14672871
31	NLK	1.03413853
32	ADRBK2	0.99057617
33	WNK3	0.90084582
34	STK39	0.88671147
35	CSNK1A1L	0.84306700
36	PRKAA2	0.83141117
37	PDK1	0.81361810
38	OXSR1	0.81260631
39	TNK2	0.77581935
40	GRK6	0.77164837
41	PRKD1	0.75507909
42	TLK1	0.74394084
43	MAP3K2	0.73947596
44	DYRK3	0.69052771
45	TRIM28	0.68766249
46	MAP3K4	0.67155545
47	MST1R	0.64846092
48	FER	0.64758911
49	NEK2	0.64091083
50	AKT3	0.59669295
51	TAF1	0.58400750
52	PTK2B	0.58148409
53	GRK1	0.55716089
54	BCKDK	0.51833581
55	KSR2	0.50649572
56	PRKCE	0.48650648
57	MAPK13	0.46565213
58	NME1	0.46521952
59	WNK1	0.45472996
60	BLK	0.45150529
61	PAK3	0.43927502
62	CSNK1G3	0.43232307
63	MARK1	0.43137690
64	CSNK1G2	0.42647097
65	PRKCI	0.41100535
66	MAPKAPK5	0.39952577
67	PRKCZ	0.39018787
68	CDK3	0.38781013
69	IKBKB	0.36328446
70	MAP2K1	0.35529105
71	DDR2	0.35062879
72	DAPK2	0.33736892
73	CAMK2A	0.31889999
74	PRKCG	0.31302841
75	MELK	0.31110081
76	CAMK1G	0.31069953
77	MAP2K7	0.29839611
78	CSNK1D	0.28854209
79	PLK1	0.28807380
80	NTRK3	0.28433577
81	MAP3K13	0.28335199
82	ARAF	0.26806060
83	ADRBK1	0.25904886
84	PRKACA	0.25138542
85	PRKCQ	0.22237675
86	PKN1	0.20449022
87	VRK1	0.20399604
88	PRKACB	0.20250468
89	GRK7	0.19586913
90	PRKG1	0.18193033
91	MAPK1	0.18168758
92	MAP3K6	0.18164427
93	NTRK2	0.17573276
94	CSNK1G1	0.16607167
95	MKNK1	0.15702896
96	GRK5	0.13591311
97	ABL2	0.12392160
98	ROCK1	0.12281316
99	CSNK1A1	0.11508800
100	PIM2	0.11147544

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.00701259
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.88178817
3	Phototransduction_Homo sapiens_hsa04744	3.85138626
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.17994246
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.11857825
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.73899387
7	Butanoate metabolism_Homo sapiens_hsa00650	2.59272908
8	Olfactory transduction_Homo sapiens_hsa04740	2.56918706
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.41025894
10	Taste transduction_Homo sapiens_hsa04742	2.20683828
11	Sphingolipid metabolism_Homo sapiens_hsa00600	2.04741714
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.04182564
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03437305
14	Caffeine metabolism_Homo sapiens_hsa00232	2.03297094
15	Nicotine addiction_Homo sapiens_hsa05033	1.89426947
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87584480
17	Morphine addiction_Homo sapiens_hsa05032	1.74168866
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70365996
19	Basal transcription factors_Homo sapiens_hsa03022	1.58385407
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.54013500
21	Propanoate metabolism_Homo sapiens_hsa00640	1.46168430
22	Fatty acid degradation_Homo sapiens_hsa00071	1.41275957
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32278120
24	One carbon pool by folate_Homo sapiens_hsa00670	1.28882780
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.28328760
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26458106
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21267343
28	ABC transporters_Homo sapiens_hsa02010	1.17049704
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15961501
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15847598
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14639494
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11161003
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.06195718
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.05729476
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.03462805
36	Peroxisome_Homo sapiens_hsa04146	1.01647084
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00663153
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.00643173
39	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00328373
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99099801
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95862312
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93347317
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.91258555
44	Viral myocarditis_Homo sapiens_hsa05416	0.88316626
45	GABAergic synapse_Homo sapiens_hsa04727	0.86838663
46	Non-homologous end-joining_Homo sapiens_hsa03450	0.84223311
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82704147
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.79965412
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79504517
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79425620
51	Retinol metabolism_Homo sapiens_hsa00830	0.77431331
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.76511500
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74428588
54	Regulation of autophagy_Homo sapiens_hsa04140	0.73074058
55	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72624087
56	Homologous recombination_Homo sapiens_hsa03440	0.71641266
57	Asthma_Homo sapiens_hsa05310	0.69193005
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68241642
59	Histidine metabolism_Homo sapiens_hsa00340	0.65272769
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64650921
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63402497
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62587232
63	Protein export_Homo sapiens_hsa03060	0.62117080
64	Purine metabolism_Homo sapiens_hsa00230	0.62007246
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.61422673
66	Oocyte meiosis_Homo sapiens_hsa04114	0.61204336
67	Allograft rejection_Homo sapiens_hsa05330	0.61116914
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59691680
69	Metabolic pathways_Homo sapiens_hsa01100	0.59680309
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59439989
71	Serotonergic synapse_Homo sapiens_hsa04726	0.58288109
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.56733968
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53623623
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.52337444
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51804659
76	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.50298578
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.49401843
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.48616485
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.47539201
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46671741
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46587871
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.45903939
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45847744
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.45502776
85	Circadian entrainment_Homo sapiens_hsa04713	0.44127921
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.44028453
87	Salivary secretion_Homo sapiens_hsa04970	0.42583694
88	Lysine degradation_Homo sapiens_hsa00310	0.42434126
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39894248
90	Oxidative phosphorylation_Homo sapiens_hsa00190	0.37969482
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.36108394
92	RNA polymerase_Homo sapiens_hsa03020	0.35578087
93	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35559465
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34310842
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33326788
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32467749
97	Huntingtons disease_Homo sapiens_hsa05016	0.31039682
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28890652
99	RNA transport_Homo sapiens_hsa03013	0.28833773
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28288955

NPIPB8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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