NPIPB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)7.46940889
2fusion of sperm to egg plasma membrane (GO:0007342)6.68711299
3sperm motility (GO:0030317)6.37270258
4establishment of protein localization to Golgi (GO:0072600)6.25457360
5protein targeting to Golgi (GO:0000042)6.01379500
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.93930330
7response to pheromone (GO:0019236)5.67199381
8retrograde transport, vesicle recycling within Golgi (GO:0000301)5.65887440
9single strand break repair (GO:0000012)5.07449864
10plasma membrane fusion (GO:0045026)4.88712349
11centriole replication (GO:0007099)4.78233370
12spermatid nucleus differentiation (GO:0007289)4.77078242
13DNA packaging (GO:0006323)4.67455036
14regulation of gamma-delta T cell differentiation (GO:0045586)4.59370724
15protein polyglutamylation (GO:0018095)4.57324764
16chromosome condensation (GO:0030261)4.45027703
17negative regulation of inclusion body assembly (GO:0090084)4.42897775
18spermatid development (GO:0007286)4.42803342
19microtubule depolymerization (GO:0007019)4.40951050
20multicellular organism reproduction (GO:0032504)4.37138184
21regulation of gamma-delta T cell activation (GO:0046643)4.21145268
22DNA methylation involved in gamete generation (GO:0043046)4.19245878
23sperm-egg recognition (GO:0035036)4.18298789
24phosphatidylethanolamine biosynthetic process (GO:0006646)4.10280113
25protein localization to Golgi apparatus (GO:0034067)4.08142538
26positive regulation of Rab GTPase activity (GO:0032851)4.03940364
27regulation of Rab GTPase activity (GO:0032313)4.03940364
28phosphatidylethanolamine metabolic process (GO:0046337)4.01730505
29reproduction (GO:0000003)4.00428835
30positive regulation of gamma-delta T cell activation (GO:0046645)3.95030576
31sperm capacitation (GO:0048240)3.94656691
32cell-cell recognition (GO:0009988)3.81000638
33microtubule polymerization or depolymerization (GO:0031109)3.80998455
34positive regulation of granulocyte differentiation (GO:0030854)3.75126077
35centriole assembly (GO:0098534)3.73675285
36binding of sperm to zona pellucida (GO:0007339)3.71751779
37cilium or flagellum-dependent cell motility (GO:0001539)3.71676815
38sexual reproduction (GO:0019953)3.68633651
39cell wall macromolecule catabolic process (GO:0016998)3.66669869
40spermatogenesis (GO:0007283)3.60079784
41axonemal dynein complex assembly (GO:0070286)3.59611985
42male gamete generation (GO:0048232)3.59064307
43positive regulation of developmental pigmentation (GO:0048087)3.57821533
44piRNA metabolic process (GO:0034587)3.56260807
45calcium ion-dependent exocytosis (GO:0017156)3.51660686
46histone mRNA catabolic process (GO:0071044)3.49404622
47regulation of B cell receptor signaling pathway (GO:0050855)3.48785879
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.46882197
49microtubule severing (GO:0051013)3.46563517
50regulation of meiosis I (GO:0060631)3.41807329
51gamete generation (GO:0007276)3.31122660
52cell wall macromolecule metabolic process (GO:0044036)3.25714868
53chromatin silencing (GO:0006342)3.23838298
54histone H3-K9 demethylation (GO:0033169)3.23577911
55rRNA methylation (GO:0031167)3.20793760
56nucleus organization (GO:0006997)3.17130386
57regulation of cilium movement (GO:0003352)3.17096407
58regulation of pigment cell differentiation (GO:0050932)3.17042697
59peptidyl-threonine dephosphorylation (GO:0035970)3.14100279
60negative regulation of Rho protein signal transduction (GO:0035024)3.13334235
61protein K48-linked deubiquitination (GO:0071108)3.10490869
62RNA destabilization (GO:0050779)3.08363330
63regulation of granulocyte differentiation (GO:0030852)3.07217189
64motile cilium assembly (GO:0044458)3.06516715
65intra-Golgi vesicle-mediated transport (GO:0006891)3.03012163
66histone H3-K36 demethylation (GO:0070544)3.02902733
67single fertilization (GO:0007338)3.02211456
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.00350186
69sphingosine metabolic process (GO:0006670)2.98611486
70organic cation transport (GO:0015695)2.93150652
71protein K11-linked deubiquitination (GO:0035871)2.92472899
72cellular response to ethanol (GO:0071361)2.90245187
73regulation of centriole replication (GO:0046599)2.88544542
74regulation of T-helper 2 cell differentiation (GO:0045628)2.88474025
75histone H3-K9 methylation (GO:0051567)2.88321059
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87750950
77histone H3-K9 modification (GO:0061647)2.87099025
78Golgi to endosome transport (GO:0006895)2.86607600
79B cell receptor signaling pathway (GO:0050853)2.84834239
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.84624981
81hepatocyte apoptotic process (GO:0097284)2.82572382
82germ cell development (GO:0007281)2.80831371
83microtubule nucleation (GO:0007020)2.79137118
84cellular ketone body metabolic process (GO:0046950)2.76273931
85regulation of T cell mediated cytotoxicity (GO:0001914)2.70301184
86nuclear pore complex assembly (GO:0051292)2.69207354
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68867914
88male meiosis I (GO:0007141)2.68848384
89regulation of interleukin-5 production (GO:0032674)2.68059424
90early endosome to late endosome transport (GO:0045022)2.67854273
91positive regulation of T cell cytokine production (GO:0002726)2.66848427
92peptidyl-lysine trimethylation (GO:0018023)2.65408748
93histone H3-K4 trimethylation (GO:0080182)2.64706341
94cellular process involved in reproduction in multicellular organism (GO:0022412)2.64465594
95regulation of histone H3-K27 methylation (GO:0061085)2.63738394
96diol metabolic process (GO:0034311)2.62240032
97negative regulation of gene expression, epigenetic (GO:0045814)2.61246533
98multicellular organismal reproductive process (GO:0048609)2.60731438
99sphingoid metabolic process (GO:0046519)2.59190397
100epithelial cilium movement (GO:0003351)2.58589678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.03896371
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97545297
3RUNX_20019798_ChIP-Seq_JUKART_Human2.81563665
4ZNF274_21170338_ChIP-Seq_K562_Hela2.43654774
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39547916
6ER_23166858_ChIP-Seq_MCF-7_Human2.25003046
7IGF1R_20145208_ChIP-Seq_DFB_Human2.17401836
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06008467
9MYB_26560356_Chip-Seq_TH2_Human2.04922133
10AR_21572438_ChIP-Seq_LNCaP_Human2.04867565
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99369478
12CBP_20019798_ChIP-Seq_JUKART_Human1.98654699
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.98654699
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97179381
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.97179381
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93036815
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90605576
18SCL_19346495_ChIP-Seq_HPC-7_Human1.84084180
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83695658
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.80699983
21FUS_26573619_Chip-Seq_HEK293_Human1.77165216
22GATA3_27048872_Chip-Seq_THYMUS_Human1.71179003
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.70775084
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69978381
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66942426
26GATA3_26560356_Chip-Seq_TH2_Human1.62521932
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.59588119
28VDR_24787735_ChIP-Seq_THP-1_Human1.56464563
29STAT3_23295773_ChIP-Seq_U87_Human1.55460889
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52396185
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51095934
32TAF15_26573619_Chip-Seq_HEK293_Human1.50517683
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47877632
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.47112418
35GATA3_26560356_Chip-Seq_TH1_Human1.45361057
36P300_19829295_ChIP-Seq_ESCs_Human1.44779545
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44359488
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44317590
39VDR_22108803_ChIP-Seq_LS180_Human1.43549863
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41786375
41MYB_26560356_Chip-Seq_TH1_Human1.41247098
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40918466
43SMRT_27268052_Chip-Seq_Bcells_Human1.40611058
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39840055
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.39537766
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.37476750
47GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35428108
48HOXB7_26014856_ChIP-Seq_BT474_Human1.33679831
49TCF4_23295773_ChIP-Seq_U87_Human1.33107124
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32364421
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31506860
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.30887928
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29088306
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.28175992
55KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24953602
56AR_25329375_ChIP-Seq_VCAP_Human1.24124446
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.23777617
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23291833
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18911082
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18230061
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.17271056
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.16914606
63SPI1_23127762_ChIP-Seq_K562_Human1.16559637
64OCT4_20526341_ChIP-Seq_ESCs_Human1.16522295
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15585402
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12880560
67RUNX2_22187159_ChIP-Seq_PCA_Human1.12807971
68TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.12685616
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12660815
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11985059
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11408348
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10972566
73RAC3_21632823_ChIP-Seq_H3396_Human1.10059877
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.09999073
75SALL4_22934838_ChIP-ChIP_CD34+_Human1.09923103
76SMAD4_21799915_ChIP-Seq_A2780_Human1.09499507
77GBX2_23144817_ChIP-Seq_PC3_Human1.08365065
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08102322
79CEBPB_22108803_ChIP-Seq_LS180_Human1.07803132
80ERA_21632823_ChIP-Seq_H3396_Human1.07426680
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.06920594
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06515367
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05174566
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04962731
85SOX2_19829295_ChIP-Seq_ESCs_Human1.04782170
86NANOG_19829295_ChIP-Seq_ESCs_Human1.04782170
87CIITA_25753668_ChIP-Seq_RAJI_Human1.03927259
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02924522
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02751958
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00706864
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00462771
92GATA1_22025678_ChIP-Seq_K562_Human1.00143775
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97946203
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97539650
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.96491773
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96316747
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96303157
98ETV1_20927104_ChIP-Seq_GIST48_Human0.95401681
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95293368
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95281816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.87815226
2MP0000569_abnormal_digit_pigmentation4.51755335
3MP0001986_abnormal_taste_sensitivity3.37853880
4MP0003646_muscle_fatigue3.11002773
5MP0005670_abnormal_white_adipose3.08071521
6MP0004381_abnormal_hair_follicle2.94198873
7MP0003763_abnormal_thymus_physiology2.59494316
8MP0003698_abnormal_male_reproductive2.43110579
9MP0005075_abnormal_melanosome_morpholog2.32174377
10MP0001929_abnormal_gametogenesis2.27073349
11MP0008877_abnormal_DNA_methylation2.23501787
12MP0000015_abnormal_ear_pigmentation2.17728772
13MP0005423_abnormal_somatic_nervous2.17183672
14MP0003436_decreased_susceptibility_to2.06959476
15MP0005310_abnormal_salivary_gland2.02408697
16MP0001800_abnormal_humoral_immune1.99836223
17MP0003724_increased_susceptibility_to1.93791904
18MP0003045_fibrosis1.93245703
19MP0008057_abnormal_DNA_replication1.92755326
20MP0002009_preneoplasia1.82682841
21MP0001835_abnormal_antigen_presentation1.77199238
22MP0002653_abnormal_ependyma_morphology1.68877107
23MP0000685_abnormal_immune_system1.60996226
24MP0003878_abnormal_ear_physiology1.58794068
25MP0005377_hearing/vestibular/ear_phenot1.58794068
26MP0002723_abnormal_immune_serum1.52701917
27MP0005671_abnormal_response_to1.52016788
28MP0005174_abnormal_tail_pigmentation1.49928107
29MP0002132_abnormal_respiratory_system1.49129551
30MP0004484_altered_response_of1.47791220
31MP0002138_abnormal_hepatobiliary_system1.45807583
32MP0000703_abnormal_thymus_morphology1.43652463
33MP0005000_abnormal_immune_tolerance1.42958509
34MP0002452_abnormal_antigen_presenting1.42591312
35MP0002837_dystrophic_cardiac_calcinosis1.39818084
36MP0005171_absent_coat_pigmentation1.38288632
37MP0002419_abnormal_innate_immunity1.36583060
38MP0009785_altered_susceptibility_to1.35957000
39MP0003656_abnormal_erythrocyte_physiolo1.34585755
40MP0009764_decreased_sensitivity_to1.30848496
41MP0002420_abnormal_adaptive_immunity1.30788453
42MP0002722_abnormal_immune_system1.29557199
43MP0009115_abnormal_fat_cell1.29174818
44MP0002332_abnormal_exercise_endurance1.28215623
45MP0001501_abnormal_sleep_pattern1.27735194
46MP0001819_abnormal_immune_cell1.27586005
47MP0002398_abnormal_bone_marrow1.26012478
48MP0001348_abnormal_lacrimal_gland1.25528202
49MP0000689_abnormal_spleen_morphology1.23941434
50MP0003787_abnormal_imprinting1.22166283
51MP0008260_abnormal_autophagy1.21944083
52MP0003221_abnormal_cardiomyocyte_apopto1.17917771
53MP0005025_abnormal_response_to1.16592931
54MP0008995_early_reproductive_senescence1.15532655
55MP0002396_abnormal_hematopoietic_system1.12446910
56MP0000716_abnormal_immune_system1.11716519
57MP0003183_abnormal_peptide_metabolism1.10247932
58MP0002161_abnormal_fertility/fecundity1.10114197
59MP0003172_abnormal_lysosome_physiology1.08659634
60MP0005387_immune_system_phenotype1.06635638
61MP0001790_abnormal_immune_system1.06635638
62MP0000427_abnormal_hair_cycle1.05226433
63MP0002405_respiratory_system_inflammati1.04317594
64MP0003718_maternal_effect1.01958648
65MP0003890_abnormal_embryonic-extraembry1.01653331
66MP0002166_altered_tumor_susceptibility0.98843407
67MP0002210_abnormal_sex_determination0.98593317
68MP0004808_abnormal_hematopoietic_stem0.95028083
69MP0005451_abnormal_body_composition0.94527817
70MP0002095_abnormal_skin_pigmentation0.93456253
71MP0003300_gastrointestinal_ulcer0.93137998
72MP0004883_abnormal_blood_vessel0.89165566
73MP0001545_abnormal_hematopoietic_system0.89057261
74MP0005397_hematopoietic_system_phenotyp0.89057261
75MP0001984_abnormal_olfaction0.88406221
76MP0001486_abnormal_startle_reflex0.88241030
77MP0003136_yellow_coat_color0.87035888
78MP0001145_abnormal_male_reproductive0.86434768
79MP0002429_abnormal_blood_cell0.83567054
80MP0005395_other_phenotype0.83464676
81MP0003828_pulmonary_edema0.82839205
82MP0002168_other_aberrant_phenotype0.78849033
83MP0000653_abnormal_sex_gland0.78466409
84MP0000371_diluted_coat_color0.76861886
85MP0005167_abnormal_blood-brain_barrier0.75649737
86MP0008961_abnormal_basal_metabolism0.74208844
87MP0008058_abnormal_DNA_repair0.73811416
88MP0005253_abnormal_eye_physiology0.72900228
89MP0001845_abnormal_inflammatory_respons0.72747782
90MP0009278_abnormal_bone_marrow0.71780390
91MP0005379_endocrine/exocrine_gland_phen0.68122470
92MP0010307_abnormal_tumor_latency0.67058737
93MP0001853_heart_inflammation0.66945807
94MP0002254_reproductive_system_inflammat0.66839646
95MP0004947_skin_inflammation0.66509720
96MP0009765_abnormal_xenobiotic_induced0.64912719
97MP0004147_increased_porphyrin_level0.63585535
98MP0001533_abnormal_skeleton_physiology0.63100227
99MP0005551_abnormal_eye_electrophysiolog0.62182227
100MP0001765_abnormal_ion_homeostasis0.61676223

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.84063927
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.62573945
3Absent/shortened dynein arms (HP:0200106)4.62573945
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.23073002
5Tubulointerstitial nephritis (HP:0001970)4.18671145
6Chronic hepatic failure (HP:0100626)4.01340100
7Hyperkalemia (HP:0002153)3.23521080
8Attenuation of retinal blood vessels (HP:0007843)3.20753344
9Abnormality of macular pigmentation (HP:0008002)3.15371150
10Amelogenesis imperfecta (HP:0000705)3.06578180
11Abnormality of the fingertips (HP:0001211)3.04983804
12Truncal obesity (HP:0001956)3.04640103
13Abnormal respiratory epithelium morphology (HP:0012253)2.97696301
14Abnormal respiratory motile cilium morphology (HP:0005938)2.97696301
15Abnormal ciliary motility (HP:0012262)2.96645854
16T lymphocytopenia (HP:0005403)2.93691776
17Postural instability (HP:0002172)2.91585473
18Hypoplasia of the thymus (HP:0000778)2.91062193
19Colitis (HP:0002583)2.77952308
20Abnormality of T cell number (HP:0011839)2.73694171
21Stomach cancer (HP:0012126)2.69714758
22Bony spicule pigmentary retinopathy (HP:0007737)2.63880613
23Progressive cerebellar ataxia (HP:0002073)2.61507908
24IgM deficiency (HP:0002850)2.61359397
25Cone-rod dystrophy (HP:0000548)2.61150116
26Abnormal spermatogenesis (HP:0008669)2.56058966
27Abnormal respiratory motile cilium physiology (HP:0012261)2.55580626
28Recurrent bacterial skin infections (HP:0005406)2.54780875
29Optic neuritis (HP:0100653)2.54269459
30Retrobulbar optic neuritis (HP:0100654)2.54269459
31Acanthocytosis (HP:0001927)2.50834764
32Volvulus (HP:0002580)2.49431855
33Genetic anticipation (HP:0003743)2.47163999
34Pancreatic cysts (HP:0001737)2.45407017
35Macular degeneration (HP:0000608)2.45313173
36Myositis (HP:0100614)2.43089270
37Aplasia/Hypoplasia of the earlobes (HP:0009906)2.40435577
38Impulsivity (HP:0100710)2.33587299
39Enlarged epiphyses (HP:0010580)2.29908431
40Abnormal rod and cone electroretinograms (HP:0008323)2.29809014
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26999409
42Resting tremor (HP:0002322)2.25558839
43Abnormality of T cells (HP:0002843)2.21221732
44Recurrent sinusitis (HP:0011108)2.20840372
45Portal hypertension (HP:0001409)2.20832610
46Orchitis (HP:0100796)2.18955687
47Abnormality of the renal medulla (HP:0100957)2.18093568
48Gastrointestinal infarctions (HP:0005244)2.17895206
49Male infertility (HP:0003251)2.17804022
50Recurrent abscess formation (HP:0002722)2.16584447
51Recurrent fungal infections (HP:0002841)2.12839796
52Poikilocytosis (HP:0004447)2.11975939
53Hypoplastic ischia (HP:0003175)2.07148722
54Abnormality of the renal cortex (HP:0011035)2.05737618
55Infertility (HP:0000789)2.04371575
56Panhypogammaglobulinemia (HP:0003139)2.03828483
57Inflammation of the large intestine (HP:0002037)2.03393113
58Tubulointerstitial abnormality (HP:0001969)2.03307173
59Neoplasm of the tracheobronchial system (HP:0100552)2.02787807
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.01576302
61Asymmetric septal hypertrophy (HP:0001670)2.00172171
62Elevated erythrocyte sedimentation rate (HP:0003565)1.98413746
63Nephronophthisis (HP:0000090)1.98333818
64Abnormality of the hepatic vasculature (HP:0006707)1.96327651
65Decreased central vision (HP:0007663)1.95194948
66Recurrent cutaneous fungal infections (HP:0011370)1.94776655
67Chronic mucocutaneous candidiasis (HP:0002728)1.94776655
68Slow saccadic eye movements (HP:0000514)1.94335321
69Alveolar cell carcinoma (HP:0006519)1.90694975
70Recurrent bronchitis (HP:0002837)1.90654001
71Thyroiditis (HP:0100646)1.90631496
72Widely spaced teeth (HP:0000687)1.90162394
73Basal cell carcinoma (HP:0002671)1.89938794
74Peripheral hypomyelination (HP:0007182)1.89312811
75Bronchiectasis (HP:0002110)1.88674018
76Abnormality of DNA repair (HP:0003254)1.88330176
77Hypochromic microcytic anemia (HP:0004840)1.88240955
78Abnormality of the columella (HP:0009929)1.88132939
79Spontaneous hematomas (HP:0007420)1.87237818
80Submucous cleft hard palate (HP:0000176)1.84283149
81Neoplasm of the heart (HP:0100544)1.84036053
82Leukocytosis (HP:0001974)1.83757694
83Horizontal nystagmus (HP:0000666)1.83323917
84Abnormality of T cell physiology (HP:0011840)1.82791066
85Recurrent skin infections (HP:0001581)1.82580600
86IgG deficiency (HP:0004315)1.79201695
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78713581
88Gastrointestinal inflammation (HP:0004386)1.78080382
89Keratoconjunctivitis (HP:0001096)1.77382395
90Poor coordination (HP:0002370)1.76878054
91Nasal polyposis (HP:0100582)1.76766637
92Gingivitis (HP:0000230)1.76712774
93Abnormality of eosinophils (HP:0001879)1.76192632
94Keratoconjunctivitis sicca (HP:0001097)1.75751672
95Facial shape deformation (HP:0011334)1.75488846
96Potter facies (HP:0002009)1.75488846
97Abnormality of chromosome stability (HP:0003220)1.74070065
98Hypoplastic iliac wings (HP:0002866)1.71613575
99Severe combined immunodeficiency (HP:0004430)1.71465831
100Photophobia (HP:0000613)1.70744191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.95753839
2STK38L3.63993787
3PLK43.50903289
4TXK3.39616337
5FRK3.33446577
6BRD42.79730681
7MAP4K22.70522081
8STK382.62642309
9NLK2.20403960
10PIK3CG2.14843010
11TAOK32.08075682
12ACVR1B2.01560600
13AKT31.76790750
14INSRR1.63714165
15WNK11.54949951
16PLK21.54853789
17MAP4K11.53630597
18GRK61.52243660
19CDK121.51202624
20MAP3K141.50151609
21PRKD31.46677410
22DDR21.43024946
23NEK61.38041871
24MAP2K21.37391555
25MARK31.37349695
26SIK21.36490542
27IKBKE1.33391823
28CAMK1G1.29047869
29PTK2B1.26699535
30LATS21.22989477
31MAP3K21.22214092
32BLK1.20495504
33KSR21.20057507
34RIPK41.19878927
35TEC1.17941042
36BMPR1B1.13777875
37PRKAA21.11135839
38BTK1.10649183
39PINK11.07287910
40PDK11.03055561
41ITK1.01585634
42MAP3K131.00385478
43PDPK11.00254998
44EPHA30.99823549
45IKBKB0.97386833
46CHUK0.96478208
47SYK0.95073566
48SIK30.91631889
49CAMK1D0.91041250
50DYRK1B0.89062084
51MARK20.89021381
52IRAK40.85088031
53JAK10.84329215
54JAK20.83474869
55MELK0.76723271
56JAK30.75505593
57ZAK0.74515414
58MAPK110.74039182
59PIM10.72315755
60TNK20.71613443
61MAPK130.70593879
62HCK0.70290258
63EPHB10.69409185
64TYK20.67855505
65SGK20.66825250
66MAP3K10.65656743
67CAMK40.63212276
68MAP3K70.61357977
69EIF2AK30.61098334
70MAPK70.59077771
71FGFR30.56350798
72TESK10.55809256
73CSK0.55532340
74LCK0.55092118
75MAP3K40.54663329
76KIT0.54526514
77FGR0.54170974
78CDK40.51173368
79LYN0.50344892
80PNCK0.49923470
81FER0.49089111
82PAK30.48837681
83TNIK0.48038519
84KSR10.42545981
85TRPM70.41754776
86CDK60.41278568
87MAPK10.40673459
88ZAP700.38820070
89SRPK10.38108686
90SGK30.37471673
91WNK30.36920072
92IRAK10.36371436
93CSNK1A1L0.33541998
94NUAK10.33492632
95SGK4940.33473661
96SGK2230.33473661
97TBK10.32868525
98FES0.32613106
99CHEK10.32075007
100CDK30.29956779

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.50816622
2Fatty acid biosynthesis_Homo sapiens_hsa000612.07700704
3B cell receptor signaling pathway_Homo sapiens_hsa046622.05408554
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00865390
5Olfactory transduction_Homo sapiens_hsa047401.84149402
6T cell receptor signaling pathway_Homo sapiens_hsa046601.84063691
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76644566
8Graft-versus-host disease_Homo sapiens_hsa053321.74634560
9Phototransduction_Homo sapiens_hsa047441.70352317
10Jak-STAT signaling pathway_Homo sapiens_hsa046301.69179159
11Taste transduction_Homo sapiens_hsa047421.66750190
12Acute myeloid leukemia_Homo sapiens_hsa052211.63384699
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61795537
14Osteoclast differentiation_Homo sapiens_hsa043801.59882294
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.58156457
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57117177
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51557100
18Primary immunodeficiency_Homo sapiens_hsa053401.50607600
19Measles_Homo sapiens_hsa051621.50067089
20Herpes simplex infection_Homo sapiens_hsa051681.41881162
21Inositol phosphate metabolism_Homo sapiens_hsa005621.40735032
22Influenza A_Homo sapiens_hsa051641.29062017
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28621845
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26996475
25ABC transporters_Homo sapiens_hsa020101.20536826
26Allograft rejection_Homo sapiens_hsa053301.18579552
27Basal transcription factors_Homo sapiens_hsa030221.17865228
28Autoimmune thyroid disease_Homo sapiens_hsa053201.17004782
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.13731029
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12998804
31Prolactin signaling pathway_Homo sapiens_hsa049171.12451023
32Hepatitis B_Homo sapiens_hsa051611.10520816
33TNF signaling pathway_Homo sapiens_hsa046681.08314121
34Non-small cell lung cancer_Homo sapiens_hsa052231.08005096
35Type I diabetes mellitus_Homo sapiens_hsa049401.07719455
36Regulation of autophagy_Homo sapiens_hsa041401.05768086
37Antigen processing and presentation_Homo sapiens_hsa046121.05183924
38Type II diabetes mellitus_Homo sapiens_hsa049301.05126306
39Leishmaniasis_Homo sapiens_hsa051401.04425800
40Tuberculosis_Homo sapiens_hsa051521.02641564
41Viral myocarditis_Homo sapiens_hsa054161.00335946
42FoxO signaling pathway_Homo sapiens_hsa040680.99213877
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.99077781
44Viral carcinogenesis_Homo sapiens_hsa052030.97855455
45mRNA surveillance pathway_Homo sapiens_hsa030150.95548707
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.94917214
47Non-homologous end-joining_Homo sapiens_hsa034500.91730681
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91407996
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88999415
50Legionellosis_Homo sapiens_hsa051340.87226260
51Sphingolipid metabolism_Homo sapiens_hsa006000.86580716
52Chemokine signaling pathway_Homo sapiens_hsa040620.84522098
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82441163
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81644727
55VEGF signaling pathway_Homo sapiens_hsa043700.80290492
56Fanconi anemia pathway_Homo sapiens_hsa034600.79547003
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79223634
58Hematopoietic cell lineage_Homo sapiens_hsa046400.78840313
59Prostate cancer_Homo sapiens_hsa052150.78569159
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78244343
61Choline metabolism in cancer_Homo sapiens_hsa052310.77832168
62Hepatitis C_Homo sapiens_hsa051600.77720191
63Morphine addiction_Homo sapiens_hsa050320.75245486
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74673110
65Circadian rhythm_Homo sapiens_hsa047100.74457616
66Epstein-Barr virus infection_Homo sapiens_hsa051690.73917852
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73851412
68Pancreatic cancer_Homo sapiens_hsa052120.73547571
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70804821
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70016634
71Platelet activation_Homo sapiens_hsa046110.69259806
72RNA transport_Homo sapiens_hsa030130.68963083
73Calcium signaling pathway_Homo sapiens_hsa040200.66449918
74Toxoplasmosis_Homo sapiens_hsa051450.66350177
75Oocyte meiosis_Homo sapiens_hsa041140.66211664
76Colorectal cancer_Homo sapiens_hsa052100.64938849
77cAMP signaling pathway_Homo sapiens_hsa040240.64172277
78Insulin resistance_Homo sapiens_hsa049310.60222354
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60104875
80Butanoate metabolism_Homo sapiens_hsa006500.59992528
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59595562
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59158890
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58611670
84Lysine degradation_Homo sapiens_hsa003100.56723576
85mTOR signaling pathway_Homo sapiens_hsa041500.54901327
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54859033
87Endometrial cancer_Homo sapiens_hsa052130.54199362
88MAPK signaling pathway_Homo sapiens_hsa040100.54041936
89Chronic myeloid leukemia_Homo sapiens_hsa052200.53854534
90Endocytosis_Homo sapiens_hsa041440.53218498
91Apoptosis_Homo sapiens_hsa042100.52951604
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.52579213
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51645169
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51542653
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.51509858
96Estrogen signaling pathway_Homo sapiens_hsa049150.50214411
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50180270
98HIF-1 signaling pathway_Homo sapiens_hsa040660.49878128
99Nicotine addiction_Homo sapiens_hsa050330.48403075
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46135358

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