ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.44486703
2	postsynaptic membrane organization (GO:0001941)	3.72216588
3	pyrimidine nucleobase catabolic process (GO:0006208)	3.55125324
4	presynaptic membrane organization (GO:0097090)	3.47374708
5	presynaptic membrane assembly (GO:0097105)	3.39189663
6	behavioral response to ethanol (GO:0048149)	3.36584938
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36361528
8	protein polyglutamylation (GO:0018095)	3.32801551
9	transmission of nerve impulse (GO:0019226)	3.19610261
10	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.10087105
11	substrate-independent telencephalic tangential migration (GO:0021826)	3.10087105
12	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.07687923
13	dendritic spine morphogenesis (GO:0060997)	3.05508265
14	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.04165401
15	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.01999733
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.00174427
17	regulation of cilium movement (GO:0003352)	3.00026111
18	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.99679736
19	nucleobase catabolic process (GO:0046113)	2.98921279
20	nonmotile primary cilium assembly (GO:0035058)	2.94188027
21	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.93123431
22	nephron epithelium morphogenesis (GO:0072088)	2.92551963
23	nephron tubule morphogenesis (GO:0072078)	2.92551963
24	piRNA metabolic process (GO:0034587)	2.92550613
25	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.92323581
26	axonal fasciculation (GO:0007413)	2.89008378
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84234290
28	neurotransmitter-gated ion channel clustering (GO:0072578)	2.81612106
29	central nervous system myelination (GO:0022010)	2.80320492
30	axon ensheathment in central nervous system (GO:0032291)	2.80320492
31	negative regulation of telomere maintenance (GO:0032205)	2.80061677
32	neuron recognition (GO:0008038)	2.78808446
33	regulation of telomere maintenance (GO:0032204)	2.78423637
34	short-term memory (GO:0007614)	2.77245965
35	C4-dicarboxylate transport (GO:0015740)	2.77025993
36	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.74090824
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72945439
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72945439
39	NADH dehydrogenase complex assembly (GO:0010257)	2.72945439
40	single strand break repair (GO:0000012)	2.72159033
41	neuron cell-cell adhesion (GO:0007158)	2.71692098
42	protein complex biogenesis (GO:0070271)	2.70286961
43	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.67123744
44	epithelial cilium movement (GO:0003351)	2.66941928
45	DNA methylation involved in gamete generation (GO:0043046)	2.64446879
46	male meiosis I (GO:0007141)	2.61161162
47	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.61103971
48	regulation of translation, ncRNA-mediated (GO:0045974)	2.61103971
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.61103971
50	resolution of meiotic recombination intermediates (GO:0000712)	2.60471319
51	regulation of penile erection (GO:0060405)	2.57300557
52	protein localization to synapse (GO:0035418)	2.55648425
53	neuronal action potential propagation (GO:0019227)	2.55646073
54	synapsis (GO:0007129)	2.55264346
55	regulation of microtubule-based movement (GO:0060632)	2.52616969
56	cell proliferation in forebrain (GO:0021846)	2.52434379
57	synaptic vesicle maturation (GO:0016188)	2.52422325
58	replication fork processing (GO:0031297)	2.49150287
59	vocalization behavior (GO:0071625)	2.47982618
60	neuronal ion channel clustering (GO:0045161)	2.47933784
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.45487541
62	acrosome reaction (GO:0007340)	2.44028481
63	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.42967651
64	somite development (GO:0061053)	2.41993310
65	establishment of mitochondrion localization (GO:0051654)	2.41486187
66	response to pheromone (GO:0019236)	2.40645744
67	renal tubule morphogenesis (GO:0061333)	2.40413427
68	regulation of DNA endoreduplication (GO:0032875)	2.39620121
69	hindbrain development (GO:0030902)	2.39331394
70	protein localization to Golgi apparatus (GO:0034067)	2.38538046
71	establishment of protein localization to Golgi (GO:0072600)	2.38509483
72	protein-cofactor linkage (GO:0018065)	2.38324235
73	synaptic transmission, glutamatergic (GO:0035249)	2.37897942
74	regulation of neurotransmitter uptake (GO:0051580)	2.36732164
75	intraciliary transport (GO:0042073)	2.36268277
76	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.35681592
77	protein localization to cilium (GO:0061512)	2.34404986
78	negative regulation of response to food (GO:0032096)	2.34266389
79	negative regulation of appetite (GO:0032099)	2.34266389
80	chemosensory behavior (GO:0007635)	2.34053554
81	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.33802567
82	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.33131436
83	synaptic transmission, cholinergic (GO:0007271)	2.32732645
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.32463981
85	auditory behavior (GO:0031223)	2.32363354
86	protein targeting to Golgi (GO:0000042)	2.32273712
87	fucose catabolic process (GO:0019317)	2.31602207
88	L-fucose metabolic process (GO:0042354)	2.31602207
89	L-fucose catabolic process (GO:0042355)	2.31602207
90	neurofilament cytoskeleton organization (GO:0060052)	2.31575215
91	synapse assembly (GO:0007416)	2.30711644
92	brain morphogenesis (GO:0048854)	2.30542994
93	spinal cord development (GO:0021510)	2.29718331
94	kidney morphogenesis (GO:0060993)	2.28602972
95	regulation of meiosis I (GO:0060631)	2.28213403
96	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.27109272
97	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.26155811
98	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.26155811
99	cerebral cortex radially oriented cell migration (GO:0021799)	2.25795271
100	behavioral defense response (GO:0002209)	2.24132736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.41215033
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.76002976
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03280092
4	VDR_22108803_ChIP-Seq_LS180_Human	2.84268452
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.61737053
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.54171825
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49033907
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40082011
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32508970
10	REST_21632747_ChIP-Seq_MESCs_Mouse	2.24516393
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.23685375
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96370722
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90947639
14	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.89963490
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88012828
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87565448
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81067991
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79353394
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78265377
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.77883005
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.77019726
22	FUS_26573619_Chip-Seq_HEK293_Human	1.76660200
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.73576005
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.73548627
25	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.68987098
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61172046
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60747185
28	P300_19829295_ChIP-Seq_ESCs_Human	1.60549695
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59845631
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59444689
31	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58461637
32	EWS_26573619_Chip-Seq_HEK293_Human	1.54709571
33	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49501646
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41181830
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37574872
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.37342118
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36858656
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.34538111
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34538111
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.32972963
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30909527
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30086420
43	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.30058635
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.29112423
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28808308
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28808308
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25306396
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25253236
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.25030942
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25006587
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24596945
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23816905
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21437934
54	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20209679
55	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.19875211
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19153256
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18837933
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18169139
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17862519
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.17212747
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16631588
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.16534218
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16519203
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.14410606
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13719668
66	STAT3_23295773_ChIP-Seq_U87_Human	1.13575247
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12624137
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12517396
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.12472137
70	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.12298867
71	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12063677
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12063677
73	TCF4_23295773_ChIP-Seq_U87_Human	1.10465905
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.10410965
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.08338860
76	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.07715525
77	AR_25329375_ChIP-Seq_VCAP_Human	1.06758166
78	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05840778
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04038874
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03041944
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02728706
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02486559
83	NCOR_22424771_ChIP-Seq_293T_Human	1.00458652
84	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.00356074
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98242290
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98100429
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96232820
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96141874
89	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.95504457
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95181442
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94953713
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94443318
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.92444019
94	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.91409462
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90453625
96	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.89056113
97	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88806521
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.88245599
99	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.87449978
100	ERA_21632823_ChIP-Seq_H3396_Human	0.87185869

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.64869016
2	MP0003122_maternal_imprinting	3.03601495
3	MP0006292_abnormal_olfactory_placode	2.98317400
4	MP0003121_genomic_imprinting	2.80240541
5	MP0008877_abnormal_DNA_methylation	2.73293181
6	MP0003123_paternal_imprinting	2.60365270
7	MP0004885_abnormal_endolymph	2.59783888
8	MP0003880_abnormal_central_pattern	2.46717958
9	MP0004859_abnormal_synaptic_plasticity	2.31857741
10	MP0001968_abnormal_touch/_nociception	2.11055855
11	MP0009046_muscle_twitch	2.07456832
12	MP0006276_abnormal_autonomic_nervous	2.06201489
13	MP0001529_abnormal_vocalization	2.02778783
14	MP0002272_abnormal_nervous_system	1.96830479
15	MP0001984_abnormal_olfaction	1.96338302
16	MP0009745_abnormal_behavioral_response	1.93730181
17	MP0003635_abnormal_synaptic_transmissio	1.84294129
18	MP0002102_abnormal_ear_morphology	1.75397192
19	MP0005551_abnormal_eye_electrophysiolog	1.74060029
20	MP0000778_abnormal_nervous_system	1.70856318
21	MP0002736_abnormal_nociception_after	1.68032719
22	MP0002063_abnormal_learning/memory/cond	1.67255287
23	MP0001188_hyperpigmentation	1.66238828
24	MP0002064_seizures	1.61114724
25	MP0002572_abnormal_emotion/affect_behav	1.60830304
26	MP0003890_abnormal_embryonic-extraembry	1.58053061
27	MP0001486_abnormal_startle_reflex	1.58020888
28	MP0005423_abnormal_somatic_nervous	1.55031443
29	MP0002735_abnormal_chemical_nociception	1.53476891
30	MP0002557_abnormal_social/conspecific_i	1.53036368
31	MP0004133_heterotaxia	1.52280423
32	MP0004142_abnormal_muscle_tone	1.51634236
33	MP0002837_dystrophic_cardiac_calcinosis	1.51438425
34	MP0004270_analgesia	1.51026374
35	MP0000631_abnormal_neuroendocrine_gland	1.46825672
36	MP0002734_abnormal_mechanical_nocicepti	1.46596494
37	MP0001485_abnormal_pinna_reflex	1.46027975
38	MP0002184_abnormal_innervation	1.43307390
39	MP0009379_abnormal_foot_pigmentation	1.42447911
40	MP0002638_abnormal_pupillary_reflex	1.40487494
41	MP0001970_abnormal_pain_threshold	1.39646491
42	MP0006072_abnormal_retinal_apoptosis	1.39517874
43	MP0000955_abnormal_spinal_cord	1.36895029
44	MP0002733_abnormal_thermal_nociception	1.36384215
45	MP0008789_abnormal_olfactory_epithelium	1.31303932
46	MP0005394_taste/olfaction_phenotype	1.30181865
47	MP0005499_abnormal_olfactory_system	1.30181865
48	MP0001293_anophthalmia	1.28200846
49	MP0002067_abnormal_sensory_capabilities	1.27558119
50	MP0002938_white_spotting	1.26415498
51	MP0002160_abnormal_reproductive_system	1.24606135
52	MP0003646_muscle_fatigue	1.23648916
53	MP0003195_calcinosis	1.21867873
54	MP0002822_catalepsy	1.21118785
55	MP0005646_abnormal_pituitary_gland	1.18560274
56	MP0009780_abnormal_chondrocyte_physiolo	1.16876229
57	MP0005377_hearing/vestibular/ear_phenot	1.16750946
58	MP0003878_abnormal_ear_physiology	1.16750946
59	MP0004811_abnormal_neuron_physiology	1.15824338
60	MP0005386_behavior/neurological_phenoty	1.15553179
61	MP0004924_abnormal_behavior	1.15553179
62	MP0008775_abnormal_heart_ventricle	1.13930205
63	MP0002882_abnormal_neuron_morphology	1.12380627
64	MP0002752_abnormal_somatic_nervous	1.10432869
65	MP0003879_abnormal_hair_cell	1.09348654
66	MP0001440_abnormal_grooming_behavior	1.09178330
67	MP0000049_abnormal_middle_ear	1.08752232
68	MP0002876_abnormal_thyroid_physiology	1.08203816
69	MP0001502_abnormal_circadian_rhythm	1.05226787
70	MP0005645_abnormal_hypothalamus_physiol	1.04501938
71	MP0002152_abnormal_brain_morphology	1.02936979
72	MP0002653_abnormal_ependyma_morphology	1.01887773
73	MP0005084_abnormal_gallbladder_morpholo	1.01646450
74	MP0004742_abnormal_vestibular_system	1.00544921
75	MP0003942_abnormal_urinary_system	0.99592766
76	MP0008995_early_reproductive_senescence	0.99279199
77	MP0005253_abnormal_eye_physiology	0.99214636
78	MP0004147_increased_porphyrin_level	0.97566754
79	MP0001963_abnormal_hearing_physiology	0.97424039
80	MP0001905_abnormal_dopamine_level	0.96615592
81	MP0003698_abnormal_male_reproductive	0.96163200
82	MP0008872_abnormal_physiological_respon	0.95845676
83	MP0005195_abnormal_posterior_eye	0.95608292
84	MP0003938_abnormal_ear_development	0.94490684
85	MP0003136_yellow_coat_color	0.94127180
86	MP0002229_neurodegeneration	0.92909437
87	MP0008058_abnormal_DNA_repair	0.91308765
88	MP0002210_abnormal_sex_determination	0.91255372
89	MP0003861_abnormal_nervous_system	0.90909017
90	MP0005410_abnormal_fertilization	0.89914471
91	MP0001986_abnormal_taste_sensitivity	0.89639754
92	MP0003283_abnormal_digestive_organ	0.89624533
93	MP0003937_abnormal_limbs/digits/tail_de	0.88684233
94	MP0003755_abnormal_palate_morphology	0.88519082
95	MP0001501_abnormal_sleep_pattern	0.88044083
96	MP0005389_reproductive_system_phenotype	0.86561729
97	MP0002233_abnormal_nose_morphology	0.86296142
98	MP0002066_abnormal_motor_capabilities/c	0.85305228
99	MP0001299_abnormal_eye_distance/	0.83812952
100	MP0001929_abnormal_gametogenesis	0.81448418

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.63013808
2	Abnormality of midbrain morphology (HP:0002418)	3.56882236
3	Molar tooth sign on MRI (HP:0002419)	3.56882236
4	Nephronophthisis (HP:0000090)	3.51613944
5	Pancreatic fibrosis (HP:0100732)	3.01603891
6	Medial flaring of the eyebrow (HP:0010747)	3.01310670
7	Acute necrotizing encephalopathy (HP:0006965)	2.85224678
8	Limb dystonia (HP:0002451)	2.74935677
9	Polyphagia (HP:0002591)	2.73346252
10	Abnormality of the renal medulla (HP:0100957)	2.66761596
11	Hyperthyroidism (HP:0000836)	2.66262747
12	Pancreatic cysts (HP:0001737)	2.64683679
13	Type II lissencephaly (HP:0007260)	2.64525854
14	Progressive macrocephaly (HP:0004481)	2.59763841
15	Volvulus (HP:0002580)	2.56759402
16	Gait imbalance (HP:0002141)	2.55243127
17	Epileptic encephalopathy (HP:0200134)	2.51973653
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.50566546
19	Lissencephaly (HP:0001339)	2.49173022
20	Colon cancer (HP:0003003)	2.47035711
21	Myokymia (HP:0002411)	2.45283925
22	Acute encephalopathy (HP:0006846)	2.45050971
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.37733950
24	Progressive cerebellar ataxia (HP:0002073)	2.36908543
25	Pachygyria (HP:0001302)	2.35768679
26	True hermaphroditism (HP:0010459)	2.35740487
27	Broad-based gait (HP:0002136)	2.31878898
28	Focal seizures (HP:0007359)	2.31465568
29	Hepatocellular necrosis (HP:0001404)	2.31357741
30	Hyperventilation (HP:0002883)	2.29537061
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29386991
32	Drooling (HP:0002307)	2.28514347
33	Septo-optic dysplasia (HP:0100842)	2.27738636
34	Mitochondrial inheritance (HP:0001427)	2.21660124
35	Congenital primary aphakia (HP:0007707)	2.21373445
36	Increased CSF lactate (HP:0002490)	2.18873343
37	Abnormal hair whorl (HP:0010721)	2.18868397
38	Spastic tetraplegia (HP:0002510)	2.15218265
39	Nephrogenic diabetes insipidus (HP:0009806)	2.14286014
40	Absent/shortened dynein arms (HP:0200106)	2.13349293
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13349293
42	Hepatic necrosis (HP:0002605)	2.13251988
43	Congenital stationary night blindness (HP:0007642)	2.12879638
44	Supernumerary spleens (HP:0009799)	2.08112295
45	Focal motor seizures (HP:0011153)	2.07856642
46	Chronic hepatic failure (HP:0100626)	2.07187739
47	Tubular atrophy (HP:0000092)	2.04075223
48	Abolished electroretinogram (ERG) (HP:0000550)	1.99689754
49	Excessive salivation (HP:0003781)	1.98476381
50	Hepatoblastoma (HP:0002884)	1.98333642
51	Genital tract atresia (HP:0001827)	1.97681212
52	Amblyopia (HP:0000646)	1.97618675
53	Growth hormone deficiency (HP:0000824)	1.97075643
54	Optic nerve hypoplasia (HP:0000609)	1.96106742
55	Neoplasm of the adrenal cortex (HP:0100641)	1.95783751
56	Abnormal drinking behavior (HP:0030082)	1.94971753
57	Polydipsia (HP:0001959)	1.94971753
58	Abnormal respiratory epithelium morphology (HP:0012253)	1.94482373
59	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94482373
60	Pendular nystagmus (HP:0012043)	1.93218823
61	Sclerocornea (HP:0000647)	1.92855735
62	Retinal dysplasia (HP:0007973)	1.92663953
63	Intestinal atresia (HP:0011100)	1.92501777
64	Prominent nasal bridge (HP:0000426)	1.92182742
65	Vaginal atresia (HP:0000148)	1.91544702
66	Narrow forehead (HP:0000341)	1.89047686
67	Anencephaly (HP:0002323)	1.87729093
68	Febrile seizures (HP:0002373)	1.86952529
69	Small hand (HP:0200055)	1.86869333
70	Hypothermia (HP:0002045)	1.86206885
71	Oligodactyly (hands) (HP:0001180)	1.85350166
72	Optic disc pallor (HP:0000543)	1.84694175
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84662660
74	Abnormal eating behavior (HP:0100738)	1.83359341
75	Abnormality of the aortic arch (HP:0012303)	1.79841679
76	Cystic liver disease (HP:0006706)	1.79824539
77	Specific learning disability (HP:0001328)	1.79641457
78	Postaxial hand polydactyly (HP:0001162)	1.78350798
79	Poor suck (HP:0002033)	1.77580181
80	Anophthalmia (HP:0000528)	1.77124778
81	Decreased muscle mass (HP:0003199)	1.75832891
82	Aganglionic megacolon (HP:0002251)	1.74964690
83	Atonic seizures (HP:0010819)	1.74565803
84	Rib fusion (HP:0000902)	1.73941099
85	Poor coordination (HP:0002370)	1.73850332
86	Generalized tonic-clonic seizures (HP:0002069)	1.72221994
87	Asplenia (HP:0001746)	1.72219028
88	Protruding tongue (HP:0010808)	1.71794352
89	Failure to thrive in infancy (HP:0001531)	1.69247950
90	Cerebral edema (HP:0002181)	1.69078165
91	Sleep apnea (HP:0010535)	1.68994805
92	Thyroid-stimulating hormone excess (HP:0002925)	1.68560722
93	Multicystic kidney dysplasia (HP:0000003)	1.67237820
94	Poor eye contact (HP:0000817)	1.66367971
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.66228174
96	Hypogonadotrophic hypogonadism (HP:0000044)	1.65712480
97	Abnormality of the corticospinal tract (HP:0002492)	1.64568489
98	Dialeptic seizures (HP:0011146)	1.64201202
99	Hyperglycinemia (HP:0002154)	1.63572387
100	Abnormal biliary tract physiology (HP:0012439)	1.63562380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.53092860
2	MARK1	3.20345437
3	FRK	3.08665427
4	TNIK	2.68839162
5	PINK1	2.68586572
6	WNK4	2.30330536
7	MAP4K2	2.26834548
8	TAOK3	2.13059170
9	MAP3K9	2.06208913
10	NTRK3	2.04115205
11	BMPR1B	1.86249203
12	DYRK2	1.83121378
13	PNCK	1.82944346
14	MAPK13	1.82917371
15	FGFR2	1.81219136
16	GRK1	1.69706740
17	MAP2K7	1.67714720
18	SIK2	1.64565107
19	WNK3	1.62002147
20	CDC7	1.60516349
21	ADRBK2	1.55579032
22	STK16	1.55338920
23	MINK1	1.55099871
24	EPHA4	1.54007781
25	MAP3K4	1.53592113
26	PLK2	1.49026254
27	MKNK2	1.45087687
28	NTRK2	1.44952015
29	PRKCG	1.41307942
30	NUAK1	1.38955226
31	PLK4	1.29224300
32	CDK19	1.23124273
33	PIK3CA	1.19601849
34	ZAK	1.18835393
35	PHKG2	1.13856009
36	PHKG1	1.13856009
37	CAMK1G	1.12136900
38	PLK3	1.11889237
39	PAK3	1.08778653
40	TYRO3	1.06141835
41	CSNK1G2	1.02016251
42	NME1	0.99961816
43	OXSR1	0.94968469
44	CAMK1	0.93967443
45	PLK1	0.93004857
46	TIE1	0.91335498
47	CDK3	0.91279944
48	MAP2K6	0.90459101
49	EIF2AK1	0.89836511
50	TTK	0.87555539
51	CSNK1G1	0.86299192
52	CSNK1E	0.82127583
53	SGK1	0.76972813
54	PAK6	0.76629120
55	SGK494	0.75409345
56	SGK223	0.75409345
57	TLK1	0.75321460
58	BCR	0.75261060
59	STK39	0.75123000
60	CSNK1G3	0.74289188
61	STK11	0.68679156
62	UHMK1	0.68330646
63	INSRR	0.66074800
64	NEK2	0.65480285
65	MKNK1	0.63643099
66	CDK5	0.63395668
67	BCKDK	0.60467037
68	DYRK1B	0.59423701
69	PRKCH	0.59021527
70	SGK2	0.58832222
71	DYRK1A	0.58814700
72	BRAF	0.58683473
73	ATM	0.57276019
74	DAPK2	0.54070970
75	PKN1	0.53951731
76	PRKCE	0.53934167
77	TAF1	0.53220146
78	CDK14	0.52994697
79	CAMK1D	0.52732715
80	STK3	0.52622687
81	EIF2AK3	0.50984974
82	STK38L	0.50186811
83	WNK1	0.49406412
84	CHEK2	0.49326778
85	CAMK2A	0.48179865
86	CSNK1A1	0.48063970
87	CSNK1A1L	0.46834762
88	PRKACA	0.46369153
89	PRKCZ	0.45860956
90	PRKAA1	0.44111774
91	PRKD3	0.42745810
92	CLK1	0.42701914
93	CDK11A	0.41708830
94	MAP2K4	0.41455563
95	PRKG1	0.41291037
96	PRKDC	0.39535846
97	NEK1	0.39152425
98	GSK3B	0.38576920
99	CSNK1D	0.38475397
100	ADRBK1	0.37986200

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.00067515
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67338822
3	Phototransduction_Homo sapiens_hsa04744	2.26558690
4	Protein export_Homo sapiens_hsa03060	2.25540886
5	Parkinsons disease_Homo sapiens_hsa05012	2.24738854
6	Butanoate metabolism_Homo sapiens_hsa00650	2.18603802
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.09574106
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.07396090
9	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95437851
10	Homologous recombination_Homo sapiens_hsa03440	1.92843185
11	Basal transcription factors_Homo sapiens_hsa03022	1.88133295
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.85889502
13	RNA polymerase_Homo sapiens_hsa03020	1.61832211
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58781254
15	GABAergic synapse_Homo sapiens_hsa04727	1.57065077
16	Olfactory transduction_Homo sapiens_hsa04740	1.55453949
17	RNA degradation_Homo sapiens_hsa03018	1.55297142
18	Insulin secretion_Homo sapiens_hsa04911	1.53435944
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.51865786
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50408718
21	Morphine addiction_Homo sapiens_hsa05032	1.49263450
22	Circadian entrainment_Homo sapiens_hsa04713	1.47277272
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.46816926
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.45443600
25	Propanoate metabolism_Homo sapiens_hsa00640	1.45219899
26	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.45204905
27	Alzheimers disease_Homo sapiens_hsa05010	1.44609396
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42837700
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40506221
30	Huntingtons disease_Homo sapiens_hsa05016	1.40154096
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31832629
32	Ribosome_Homo sapiens_hsa03010	1.29793420
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24792638
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24641285
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.21986079
36	Taste transduction_Homo sapiens_hsa04742	1.21181772
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.20223946
38	Cocaine addiction_Homo sapiens_hsa05030	1.17044552
39	Amphetamine addiction_Homo sapiens_hsa05031	1.16466893
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15971641
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15444459
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15244649
43	Regulation of autophagy_Homo sapiens_hsa04140	1.14748499
44	Peroxisome_Homo sapiens_hsa04146	1.12341686
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.09065071
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08621373
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07158985
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05736417
49	Tryptophan metabolism_Homo sapiens_hsa00380	1.04996221
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04425445
51	RNA transport_Homo sapiens_hsa03013	0.99837754
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.96892180
53	One carbon pool by folate_Homo sapiens_hsa00670	0.95740717
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94608845
55	Serotonergic synapse_Homo sapiens_hsa04726	0.93672558
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.90284051
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88131467
58	Long-term depression_Homo sapiens_hsa04730	0.86089368
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85964007
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82198151
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.76820981
62	Oocyte meiosis_Homo sapiens_hsa04114	0.76138069
63	Fatty acid degradation_Homo sapiens_hsa00071	0.75747770
64	Cholinergic synapse_Homo sapiens_hsa04725	0.75456633
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.74945074
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71202825
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70796321
68	Retinol metabolism_Homo sapiens_hsa00830	0.69610606
69	Metabolic pathways_Homo sapiens_hsa01100	0.68221600
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67443963
71	Mismatch repair_Homo sapiens_hsa03430	0.67279117
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65415905
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64161480
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.64018937
75	Purine metabolism_Homo sapiens_hsa00230	0.63229403
76	Axon guidance_Homo sapiens_hsa04360	0.61657467
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60060152
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.57455176
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56967840
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56766755
81	Fatty acid elongation_Homo sapiens_hsa00062	0.56683236
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56674049
83	Long-term potentiation_Homo sapiens_hsa04720	0.52868272
84	Spliceosome_Homo sapiens_hsa03040	0.52566583
85	Sulfur relay system_Homo sapiens_hsa04122	0.52499865
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.52434336
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52233991
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51559292
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50325919
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49321980
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49101758
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48583040
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.46883333
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.45861888
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.44029260
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43062788
97	Salivary secretion_Homo sapiens_hsa04970	0.42839562
98	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42574627
99	Renin secretion_Homo sapiens_hsa04924	0.41521643
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39117835

NPIPP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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