NPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.69246820
2negative regulation of interleukin-12 production (GO:0032695)5.43816610
3purine nucleobase biosynthetic process (GO:0009113)5.28316464
4response to peptidoglycan (GO:0032494)5.18778651
5positive regulation by symbiont of host defense response (GO:0052509)5.01931020
6modulation by symbiont of host defense response (GO:0052031)5.01931020
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01931020
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01931020
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.01931020
10modulation by symbiont of host immune response (GO:0052553)5.01931020
11macrophage activation involved in immune response (GO:0002281)4.89031657
12positive regulation of gamma-delta T cell activation (GO:0046645)4.85519602
13nucleobase biosynthetic process (GO:0046112)4.74943245
14detection of molecule of bacterial origin (GO:0032490)4.74863773
15maturation of SSU-rRNA (GO:0030490)4.74453508
16rRNA modification (GO:0000154)4.73458781
17mitotic metaphase plate congression (GO:0007080)4.71817031
18ribosome assembly (GO:0042255)4.64564820
19proteasome assembly (GO:0043248)4.42357583
20DNA replication checkpoint (GO:0000076)4.42005785
21DNA deamination (GO:0045006)4.41180130
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.40778933
23termination of RNA polymerase III transcription (GO:0006386)4.40778933
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30832589
25negative regulation of cell killing (GO:0031342)4.30832589
26detection of other organism (GO:0098543)4.19661265
27ribosome biogenesis (GO:0042254)4.11444844
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.09940614
29termination of RNA polymerase I transcription (GO:0006363)4.07805629
30detection of external biotic stimulus (GO:0098581)4.07206208
31positive regulation of mast cell activation (GO:0033005)4.06599491
32ribosomal large subunit biogenesis (GO:0042273)4.05009851
33transcription elongation from RNA polymerase I promoter (GO:0006362)4.04489883
34immunoglobulin mediated immune response (GO:0016064)4.04221350
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04068837
36ribonucleoprotein complex biogenesis (GO:0022613)3.99936910
37regulation of mast cell degranulation (GO:0043304)3.98506659
38cellular extravasation (GO:0045123)3.94578551
39granulocyte activation (GO:0036230)3.94514321
40ribosomal small subunit biogenesis (GO:0042274)3.87191076
41ribosomal small subunit assembly (GO:0000028)3.86891677
42rRNA methylation (GO:0031167)3.86510342
43microglial cell activation (GO:0001774)3.86099548
44regulation of interferon-beta biosynthetic process (GO:0045357)3.85396632
45positive regulation of mast cell degranulation (GO:0043306)3.82977166
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.82977166
47neutrophil activation (GO:0042119)3.81763707
487-methylguanosine mRNA capping (GO:0006370)3.81270786
49macrophage activation (GO:0042116)3.80858556
50folic acid metabolic process (GO:0046655)3.78800661
51glycosphingolipid catabolic process (GO:0046479)3.78365492
52regulation of spindle organization (GO:0090224)3.77742937
53cellular response to thyroid hormone stimulus (GO:0097067)3.77407381
54transcription from RNA polymerase I promoter (GO:0006360)3.77136937
55metaphase plate congression (GO:0051310)3.76145817
56detection of bacterium (GO:0016045)3.72854931
577-methylguanosine RNA capping (GO:0009452)3.72840202
58RNA capping (GO:0036260)3.72840202
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72456219
60regulation of mast cell activation involved in immune response (GO:0033006)3.70933847
61rRNA processing (GO:0006364)3.70285306
62CENP-A containing nucleosome assembly (GO:0034080)3.68173047
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.66348935
64folic acid transport (GO:0015884)3.64363020
65myeloid cell activation involved in immune response (GO:0002275)3.61245369
66rRNA metabolic process (GO:0016072)3.60726312
67oligosaccharide catabolic process (GO:0009313)3.58655642
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58207800
69detection of biotic stimulus (GO:0009595)3.56270724
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52982803
71formation of translation preinitiation complex (GO:0001731)3.52803921
72regulation of mast cell activation (GO:0033003)3.52265855
73positive regulation of cellular amide metabolic process (GO:0034250)3.51906254
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51286151
75respiratory burst (GO:0045730)3.47053322
76regulation of leukocyte degranulation (GO:0043300)3.46458428
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.46353475
78transcription initiation from RNA polymerase I promoter (GO:0006361)3.45831759
79T-helper 1 type immune response (GO:0042088)3.45009595
80chromatin remodeling at centromere (GO:0031055)3.44792864
81DNA replication initiation (GO:0006270)3.43548977
82regulation of mononuclear cell migration (GO:0071675)3.41094499
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40478789
84positive regulation of leukocyte degranulation (GO:0043302)3.39415525
85response to host immune response (GO:0052572)3.39302717
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39302717
87kinetochore assembly (GO:0051382)3.39207577
88positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.39196874
89DNA strand elongation involved in DNA replication (GO:0006271)3.38359126
90glycolipid catabolic process (GO:0019377)3.38119535
91regulation of gamma-delta T cell activation (GO:0046643)3.37943375
92DNA replication-independent nucleosome organization (GO:0034724)3.29948360
93DNA replication-independent nucleosome assembly (GO:0006336)3.29948360
94regulation of B cell receptor signaling pathway (GO:0050855)3.29773384
95DNA strand elongation (GO:0022616)3.29762785
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27492395
97pseudouridine synthesis (GO:0001522)3.23990648
98viral transcription (GO:0019083)3.23679590
99interferon-gamma secretion (GO:0072643)3.23383199
100spliceosomal snRNP assembly (GO:0000387)3.23358232
101telomere maintenance via semi-conservative replication (GO:0032201)3.21597439
102translational termination (GO:0006415)3.20417727
103DNA-templated transcription, elongation (GO:0006354)3.19879897
104transcription elongation from RNA polymerase II promoter (GO:0006368)3.19753741
105positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.18887672
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18049910
107maturation of 5.8S rRNA (GO:0000460)3.17300968
108translational initiation (GO:0006413)3.17254400
109regulation of nuclear cell cycle DNA replication (GO:0033262)3.16639456
110interferon-gamma-mediated signaling pathway (GO:0060333)3.15701084
111lung-associated mesenchyme development (GO:0060484)3.15241556
112telomere maintenance via recombination (GO:0000722)3.13950246
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13560691
114blastocyst development (GO:0001824)3.13549584
115* amino sugar catabolic process (GO:0046348)3.13457984
116negative regulation of erythrocyte differentiation (GO:0045647)3.12891411
117regulation of double-strand break repair via homologous recombination (GO:0010569)3.09530431
118transcription-coupled nucleotide-excision repair (GO:0006283)3.09245212
119histone exchange (GO:0043486)3.08168043
120B cell mediated immunity (GO:0019724)3.07476678
121cellular component biogenesis (GO:0044085)3.07056373
122germinal center formation (GO:0002467)3.06161295
123establishment of chromosome localization (GO:0051303)3.05811551
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04819504
125negative regulation of ligase activity (GO:0051352)3.03810698
126negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03810698
127regulation of cellular amino acid metabolic process (GO:0006521)3.03490711
128kinetochore organization (GO:0051383)3.01754070
129positive regulation of toll-like receptor signaling pathway (GO:0034123)3.01703099
130positive regulation of monocyte chemotaxis (GO:0090026)3.01668904
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99762921
132ceramide catabolic process (GO:0046514)2.98784397
133DNA-dependent DNA replication (GO:0006261)2.98679623
134negative regulation of cytokine production involved in immune response (GO:0002719)2.98541913
135antigen processing and presentation of endogenous antigen (GO:0019883)2.98429923
136meiosis I (GO:0007127)2.98378827
137positive regulation of ligase activity (GO:0051351)2.97485326
138regulation of interferon-alpha production (GO:0032647)2.96987343
139spindle checkpoint (GO:0031577)2.96307702
140response to host (GO:0075136)2.95929220
141response to host defenses (GO:0052200)2.95929220
142response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95929220
143positive regulation of antigen processing and presentation (GO:0002579)2.95317205
144positive regulation of viral transcription (GO:0050434)2.93501679
145regulation of mitotic spindle organization (GO:0060236)2.91692628
146production of molecular mediator involved in inflammatory response (GO:0002532)2.91272582
147response to muramyl dipeptide (GO:0032495)2.91151158
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91143479
149positive regulation of chromosome segregation (GO:0051984)2.90074086
150mitotic recombination (GO:0006312)2.89058913
151signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88339864
152signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88339864
153signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88339864
154myeloid leukocyte activation (GO:0002274)2.88243372
155regulation of macrophage chemotaxis (GO:0010758)2.87766431
156regulation of histone H3-K27 methylation (GO:0061085)2.87111919
157keratinocyte development (GO:0003334)2.86386619
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.86368485
159response to thyroid hormone (GO:0097066)2.86077867
160superoxide anion generation (GO:0042554)2.85942223
161positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.85734641
162regulation of T-helper 2 cell differentiation (GO:0045628)2.85583771
163signal transduction involved in DNA damage checkpoint (GO:0072422)2.85475522
164signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85475522
165positive regulation of interferon-alpha production (GO:0032727)2.84701557
166cell cycle G1/S phase transition (GO:0044843)2.84337975
167G1/S transition of mitotic cell cycle (GO:0000082)2.84337975
168protein K6-linked ubiquitination (GO:0085020)2.83866239
169telomere maintenance via telomere lengthening (GO:0010833)2.83503890
170DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83382119
171attachment of spindle microtubules to kinetochore (GO:0008608)2.83064439
172translational elongation (GO:0006414)2.82983590
173negative regulation of interleukin-17 production (GO:0032700)2.82138696
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.81367710
175myeloid dendritic cell differentiation (GO:0043011)2.81292541
176regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80624585
177positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80567343
178regulation of regulated secretory pathway (GO:1903305)2.80463326
179regulation of T cell tolerance induction (GO:0002664)2.80139549
180regulation of antigen processing and presentation (GO:0002577)2.78848823
181neutrophil chemotaxis (GO:0030593)2.78566549
182signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78209932
183intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78209932
184phagosome maturation (GO:0090382)2.78082537
185protein localization to kinetochore (GO:0034501)2.77814888
186DNA-templated transcription, termination (GO:0006353)2.76900208
187negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76733557
188negative regulation of lymphocyte mediated immunity (GO:0002707)2.76502382
189leukocyte migration involved in inflammatory response (GO:0002523)2.75568118
190cellular response to type I interferon (GO:0071357)2.75352638
191type I interferon signaling pathway (GO:0060337)2.75352638
192hydrogen peroxide biosynthetic process (GO:0050665)2.75021624
193neutrophil mediated immunity (GO:0002446)2.74811006
194positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73696948
195defense response to protozoan (GO:0042832)2.73676818
196myeloid dendritic cell activation (GO:0001773)2.72161164
197antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71875977
198response to type I interferon (GO:0034340)2.71665945
199neutrophil migration (GO:1990266)2.71461320
200negative regulation of leukocyte mediated immunity (GO:0002704)2.71038276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.35989324
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.56866991
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.44280038
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.85023367
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.21206902
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98488129
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.88494919
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85345797
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60574320
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52817181
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49202276
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.45637110
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.40640043
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.36842725
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.31327008
16EST1_17652178_ChIP-ChIP_JURKAT_Human3.25390941
17MYB_21317192_ChIP-Seq_ERMYB_Mouse3.18413835
18FOXM1_23109430_ChIP-Seq_U2OS_Human3.16894057
19E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10512317
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08861480
21CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05517726
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98485780
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83018915
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81878026
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76384600
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75530679
27SPI1_23127762_ChIP-Seq_K562_Human2.74138831
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72449611
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64152596
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63679793
31* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55399233
32VDR_23849224_ChIP-Seq_CD4+_Human2.52330976
33SCL_19346495_ChIP-Seq_HPC-7_Human2.48141339
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46880355
35* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42329100
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40432876
37VDR_24763502_ChIP-Seq_THP-1_Human2.40267439
38VDR_24787735_ChIP-Seq_THP-1_Human2.37785135
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36228610
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35628130
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33595704
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29578880
43BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28078124
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23355862
45STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22379732
46AR_21909140_ChIP-Seq_LNCAP_Human2.16246242
47NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12047218
48NANOG_18555785_ChIP-Seq_MESCs_Mouse2.10471265
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09513257
50XRN2_22483619_ChIP-Seq_HELA_Human2.02214177
51VDR_21846776_ChIP-Seq_THP-1_Human2.02141133
52FOXP3_21729870_ChIP-Seq_TREG_Human2.01127687
53E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00247856
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96640624
55RUNX_20019798_ChIP-Seq_JUKART_Human1.95396757
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.94235419
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93964566
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91543637
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87919137
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86838184
61DCP1A_22483619_ChIP-Seq_HELA_Human1.84732190
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.79323221
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78188036
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.77994379
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76970776
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75497223
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74665329
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.74596811
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.73326657
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71963411
71* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69925091
72TTF2_22483619_ChIP-Seq_HELA_Human1.69855681
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69820585
74PU_27001747_Chip-Seq_BMDM_Mouse1.69291953
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68544054
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68156309
77GABP_19822575_ChIP-Seq_HepG2_Human1.68082782
78MYB_26560356_Chip-Seq_TH2_Human1.67392073
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.66656205
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65492265
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63974785
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.61369684
83GATA1_19941826_ChIP-Seq_K562_Human1.61352713
84ELK1_19687146_ChIP-ChIP_HELA_Human1.59188230
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58774921
86* MAF_26560356_Chip-Seq_TH1_Human1.58322909
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57018133
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56725580
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54328301
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.47102978
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44454515
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.43935310
93* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42496796
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40489121
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38093921
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37528508
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36284554
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36257650
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35904496
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35781167
101GATA1_22025678_ChIP-Seq_K562_Human1.34902735
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34757170
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.32820119
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32502078
105MYB_26560356_Chip-Seq_TH1_Human1.32127009
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31955715
107UTX_26944678_Chip-Seq_JUKART_Human1.31656977
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31040916
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.30931690
110KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30730633
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30323818
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.29798364
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28156463
114GATA3_27048872_Chip-Seq_THYMUS_Human1.28057177
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27247042
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27120834
117KDM5A_27292631_Chip-Seq_BREAST_Human1.26291046
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25898149
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24203739
120* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23769485
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23667561
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23311135
123TCF7_22412390_ChIP-Seq_EML_Mouse1.21621963
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21501042
125* GATA2_19941826_ChIP-Seq_K562_Human1.21182751
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20616885
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17455058
128STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17216684
129GATA3_26560356_Chip-Seq_TH2_Human1.15697618
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14668930
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14453925
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14133397
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12312618
134CIITA_25753668_ChIP-Seq_RAJI_Human1.11592219
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10202310
136ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09037091
137SPI1_23547873_ChIP-Seq_NB4_Human1.08229439
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06660316
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05069838
140* MAF_26560356_Chip-Seq_TH2_Human1.01570423
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01317322
142SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01098405
143IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00250355
144STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00017223
145LXR_22292898_ChIP-Seq_THP-1_Human0.99528693
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99313313
147* KDM2B_26808549_Chip-Seq_DND41_Human0.97823810
148SALL1_21062744_ChIP-ChIP_HESCs_Human0.96882983
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96810004
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95974890
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95670067
152KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95188183
153* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94858303
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94554525
155MYC_22102868_ChIP-Seq_BL_Human0.94469795
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94274166
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93560385
158STAT1_20625510_ChIP-Seq_HELA_Human0.92246561
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89848149
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89733536
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89401476
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.88026368
163GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87741367
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86455360
165FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85446109
166KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85213343
167KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85213343
168KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85213343
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85183249
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84494232
171BCL6_27268052_Chip-Seq_Bcells_Human0.84460170
172MYC_18940864_ChIP-ChIP_HL60_Human0.84400989
173POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83749969
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83462277
175E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83353090
176SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82693048
177PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82226803
178BCOR_27268052_Chip-Seq_Bcells_Human0.81844782
179TFEB_21752829_ChIP-Seq_HELA_Human0.81740390
180LXR_22158963_ChIP-Seq_LIVER_Mouse0.81316447
181KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81173743
182RXR_22158963_ChIP-Seq_LIVER_Mouse0.79947669
183BP1_19119308_ChIP-ChIP_Hs578T_Human0.79614900
184PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78607692
185SPI1_20517297_ChIP-Seq_HL60_Human0.76461255
186PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76334258
187NANOG_21062744_ChIP-ChIP_HESCs_Human0.76112092
188TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75562967
189STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75351844
190SMRT_27268052_Chip-Seq_Bcells_Human0.73517296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.94243373
2MP0003111_abnormal_nucleus_morphology4.48893000
3MP0003303_peritoneal_inflammation4.17761108
4MP0003724_increased_susceptibility_to4.04483830
5MP0010094_abnormal_chromosome_stability3.84434386
6MP0004957_abnormal_blastocyst_morpholog3.54260630
7MP0008057_abnormal_DNA_replication3.50595465
8MP0003436_decreased_susceptibility_to3.43035902
9MP0008058_abnormal_DNA_repair3.42899690
10MP0006082_CNS_inflammation3.41907651
11MP0003718_maternal_effect3.32072879
12MP0003077_abnormal_cell_cycle3.23066913
13MP0008260_abnormal_autophagy3.17452903
14MP0002419_abnormal_innate_immunity3.02742317
15MP0003172_abnormal_lysosome_physiology2.90999178
16MP0009785_altered_susceptibility_to2.80839902
17MP0003941_abnormal_skin_development2.77592917
18MP0002396_abnormal_hematopoietic_system2.74605681
19MP0008007_abnormal_cellular_replicative2.69962538
20MP0003786_premature_aging2.67535506
21MP0003191_abnormal_cellular_cholesterol2.65543862
22MP0005000_abnormal_immune_tolerance2.55370345
23MP0005025_abnormal_response_to2.55338218
24MP0005387_immune_system_phenotype2.49966110
25MP0001790_abnormal_immune_system2.49966110
26MP0000685_abnormal_immune_system2.32221709
27MP0003300_gastrointestinal_ulcer2.32146792
28MP0002452_abnormal_antigen_presenting2.29383874
29MP0002723_abnormal_immune_serum2.21653131
30MP0001800_abnormal_humoral_immune2.21043029
31MP0000343_altered_response_to2.18014827
32MP0003136_yellow_coat_color2.17517342
33MP0000604_amyloidosis2.13985181
34MP0001533_abnormal_skeleton_physiology2.07082773
35MP0003315_abnormal_perineum_morphology2.05215645
36MP0008932_abnormal_embryonic_tissue2.02904847
37MP0006292_abnormal_olfactory_placode2.00966053
38MP0002420_abnormal_adaptive_immunity1.98999905
39MP0009764_decreased_sensitivity_to1.98220112
40MP0001819_abnormal_immune_cell1.98086965
41MP0003075_altered_response_to1.95574685
42MP0005377_hearing/vestibular/ear_phenot1.95525995
43MP0003878_abnormal_ear_physiology1.95525995
44MP0003690_abnormal_glial_cell1.83585621
45MP0009278_abnormal_bone_marrow1.81036202
46MP0002132_abnormal_respiratory_system1.78752679
47MP0004510_myositis1.78296392
48MP0002405_respiratory_system_inflammati1.76986529
49MP0001845_abnormal_inflammatory_respons1.76261959
50MP0009840_abnormal_foam_cell1.76127182
51MP0008877_abnormal_DNA_methylation1.71770602
52MP0002998_abnormal_bone_remodeling1.69350211
53MP0000490_abnormal_crypts_of1.68090371
54MP0002139_abnormal_hepatobiliary_system1.66864442
55MP0005310_abnormal_salivary_gland1.66427356
56MP0002277_abnormal_respiratory_mucosa1.63799932
57MP0009333_abnormal_splenocyte_physiolog1.61788208
58MP0003656_abnormal_erythrocyte_physiolo1.57509383
59MP0008469_abnormal_protein_level1.56000047
60MP0008004_abnormal_stomach_pH1.53058572
61MP0005167_abnormal_blood-brain_barrier1.51468064
62MP0004947_skin_inflammation1.51445329
63MP0010155_abnormal_intestine_physiology1.51329934
64MP0004019_abnormal_vitamin_homeostasis1.50108828
65MP0004381_abnormal_hair_follicle1.46558065
66MP0000383_abnormal_hair_follicle1.43813484
67MP0005058_abnormal_lysosome_morphology1.42255623
68MP0002102_abnormal_ear_morphology1.41461124
69MP0000716_abnormal_immune_system1.40794733
70MP0000858_altered_metastatic_potential1.37272018
71MP0000465_gastrointestinal_hemorrhage1.35445943
72MP0004808_abnormal_hematopoietic_stem1.35393366
73MP0000350_abnormal_cell_proliferation1.35291822
74MP0001730_embryonic_growth_arrest1.31749939
75MP0003938_abnormal_ear_development1.30356536
76MP0002210_abnormal_sex_determination1.28661390
77MP0008995_early_reproductive_senescence1.27801354
78MP0003448_altered_tumor_morphology1.27800276
79MP0000566_synostosis1.27649314
80MP0004883_abnormal_blood_vessel1.25138259
81MP0003183_abnormal_peptide_metabolism1.24929195
82MP0003806_abnormal_nucleotide_metabolis1.22659163
83MP0002796_impaired_skin_barrier1.21036981
84MP0010307_abnormal_tumor_latency1.20325882
85MP0001545_abnormal_hematopoietic_system1.19962388
86MP0005397_hematopoietic_system_phenotyp1.19962388
87MP0005075_abnormal_melanosome_morpholog1.19598865
88MP0003123_paternal_imprinting1.16016365
89MP0001188_hyperpigmentation1.13879482
90MP0005164_abnormal_response_to1.13817495
91MP0005166_decreased_susceptibility_to1.13286310
92MP0001145_abnormal_male_reproductive1.11672163
93MP0001542_abnormal_bone_strength1.11030611
94MP0003186_abnormal_redox_activity1.10003278
95MP0002095_abnormal_skin_pigmentation1.09834429
96MP0005451_abnormal_body_composition1.09801027
97MP0003567_abnormal_fetal_cardiomyocyte1.09338764
98MP0002254_reproductive_system_inflammat1.05009006
99MP0006054_spinal_hemorrhage1.04811867
100MP0001672_abnormal_embryogenesis/_devel1.03962764
101MP0005380_embryogenesis_phenotype1.03962764
102MP0000313_abnormal_cell_death1.03911727
103MP0001929_abnormal_gametogenesis1.03100130
104MP0005395_other_phenotype1.02810732
105MP0000920_abnormal_myelination1.02217566
106MP0000015_abnormal_ear_pigmentation0.99473138
107MP0000653_abnormal_sex_gland0.99205850
108MP0000647_abnormal_sebaceous_gland0.97894113
109MP0003329_amyloid_beta_deposits0.97536196
110MP0003453_abnormal_keratinocyte_physiol0.96840661
111MP0009763_increased_sensitivity_to0.95849183
112MP0005501_abnormal_skin_physiology0.95041769
113MP0001119_abnormal_female_reproductive0.94302203
114MP0004147_increased_porphyrin_level0.92729725
115MP0002080_prenatal_lethality0.92393014
116MP0001851_eye_inflammation0.90496024
117MP0005671_abnormal_response_to0.89262590
118MP0002019_abnormal_tumor_incidence0.87493922
119MP0000569_abnormal_digit_pigmentation0.87113434
120MP0002160_abnormal_reproductive_system0.87059826
121MP0001853_heart_inflammation0.86145734
122MP0003195_calcinosis0.85909623
123MP0002098_abnormal_vibrissa_morphology0.85633494
124MP0002722_abnormal_immune_system0.85510357
125MP0005389_reproductive_system_phenotype0.84494930
126MP0002148_abnormal_hypersensitivity_rea0.84266880
127MP0001216_abnormal_epidermal_layer0.83992032
128MP0001697_abnormal_embryo_size0.81866337
129MP0005365_abnormal_bile_salt0.81178448
130MP0003984_embryonic_growth_retardation0.80743187
131MP0001986_abnormal_taste_sensitivity0.79616071
132MP0000689_abnormal_spleen_morphology0.79543255
133MP0002938_white_spotting0.79474631
134MP0009379_abnormal_foot_pigmentation0.78852622
135MP0005174_abnormal_tail_pigmentation0.78661640
136MP0002088_abnormal_embryonic_growth/wei0.78002417
137MP0005390_skeleton_phenotype0.77786842
138MP0003795_abnormal_bone_structure0.77321950
139MP0001663_abnormal_digestive_system0.76701818
140MP0003763_abnormal_thymus_physiology0.76697985
141MP0002138_abnormal_hepatobiliary_system0.76684816
142MP0002085_abnormal_embryonic_tissue0.76530576
143MP0001835_abnormal_antigen_presentation0.76005735
144MP0002086_abnormal_extraembryonic_tissu0.70861535
145MP0003866_abnormal_defecation0.70620808
146MP0005464_abnormal_platelet_physiology0.70471856
147MP0000371_diluted_coat_color0.70324552
148MP0002638_abnormal_pupillary_reflex0.69944084
149MP0000249_abnormal_blood_vessel0.69370341
150MP0001661_extended_life_span0.68975745
151MP0002697_abnormal_eye_size0.68750881
152MP0002332_abnormal_exercise_endurance0.68665885
153MP0008874_decreased_physiological_sensi0.68252152
154MP0003828_pulmonary_edema0.68066059
155MP0009765_abnormal_xenobiotic_induced0.66284636
156MP0002877_abnormal_melanocyte_morpholog0.65326331
157MP0001293_anophthalmia0.65147077
158MP0004264_abnormal_extraembryonic_tissu0.63942771
159MP0009697_abnormal_copulation0.63426699
160MP0000627_abnormal_mammary_gland0.63065933
161MP0002398_abnormal_bone_marrow0.62752314
162MP0003699_abnormal_female_reproductive0.62480345
163MP0002429_abnormal_blood_cell0.61813966
164MP0001286_abnormal_eye_development0.61239981
165MP0002092_abnormal_eye_morphology0.60958486
166MP0010678_abnormal_skin_adnexa0.59991348
167MP0005621_abnormal_cell_physiology0.59984515
168MP0005165_increased_susceptibility_to0.59534976
169MP0005319_abnormal_enzyme/_coenzyme0.58765459
170MP0000609_abnormal_liver_physiology0.58652191
171MP0000703_abnormal_thymus_morphology0.56524089
172MP0005647_abnormal_sex_gland0.54184192
173MP0003091_abnormal_cell_migration0.53205839
174MP0002090_abnormal_vision0.52865063
175MP0005584_abnormal_enzyme/coenzyme_acti0.51870993
176MP0003633_abnormal_nervous_system0.51704476

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.96939665
2Abnormality of liposaccharide metabolism (HP:0010968)6.96939665
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.96939665
4Abnormality of macrophages (HP:0004311)5.50057015
5Recurrent bacterial skin infections (HP:0005406)5.40646773
6Recurrent abscess formation (HP:0002722)5.36472254
7Eczematoid dermatitis (HP:0000976)5.34902404
8Increased cerebral lipofuscin (HP:0011813)5.04007560
9Birth length less than 3rd percentile (HP:0003561)4.97706637
10Breast hypoplasia (HP:0003187)4.52034585
11Recurrent gram-negative bacterial infections (HP:0005420)4.46715480
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38684473
13Systemic lupus erythematosus (HP:0002725)4.34394155
14Dysostosis multiplex (HP:0000943)4.23109910
15Disinhibition (HP:0000734)4.21348450
16Chromsome breakage (HP:0040012)4.10164936
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.09506779
18Reticulocytopenia (HP:0001896)4.07673786
19Orchitis (HP:0100796)4.04099318
20Myositis (HP:0100614)3.99654890
21Loss of speech (HP:0002371)3.94963202
22Retrobulbar optic neuritis (HP:0100654)3.89248693
23Optic neuritis (HP:0100653)3.89248693
24Rough bone trabeculation (HP:0100670)3.83954513
25Stomatitis (HP:0010280)3.78956778
26Spontaneous hematomas (HP:0007420)3.71402831
27Mediastinal lymphadenopathy (HP:0100721)3.67331100
28Impulsivity (HP:0100710)3.60232706
29Mutism (HP:0002300)3.43833634
30Obstructive lung disease (HP:0006536)3.35854469
31Chronic obstructive pulmonary disease (HP:0006510)3.35854469
32Carpal bone hypoplasia (HP:0001498)3.35809379
33Abnormality of the preputium (HP:0100587)3.32968894
34Purpura (HP:0000979)3.26990438
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25180984
36Abnormality of polysaccharide metabolism (HP:0011012)3.25180984
37Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25180984
38Abnormality of cells of the erythroid lineage (HP:0012130)3.21271583
39Recurrent skin infections (HP:0001581)3.20996884
40Macrocytic anemia (HP:0001972)3.14871233
41Autoimmune thrombocytopenia (HP:0001973)3.13938188
42Abnormal number of erythroid precursors (HP:0012131)3.11666963
43Meckel diverticulum (HP:0002245)3.09726068
44Urinary glycosaminoglycan excretion (HP:0003541)3.07599271
45Mucopolysacchariduria (HP:0008155)3.07599271
46Patellar aplasia (HP:0006443)3.02420458
47Abnormality of the vasculature of the conjunctiva (HP:0008054)3.02256893
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01345232
49Abnormal trabecular bone morphology (HP:0100671)3.01281970
50Oral leukoplakia (HP:0002745)2.95911109
51Gingivitis (HP:0000230)2.95482380
52Aplasia/Hypoplasia of the patella (HP:0006498)2.94816980
53Recurrent fungal infections (HP:0002841)2.91082652
54Abnormality of the ileum (HP:0001549)2.89616231
55Ureteral duplication (HP:0000073)2.88615364
56Petechiae (HP:0000967)2.87116429
57Prostate neoplasm (HP:0100787)2.86273451
58Glomerulonephritis (HP:0000099)2.84975460
59Bone marrow hypocellularity (HP:0005528)2.84716886
60Aplastic anemia (HP:0001915)2.82806190
61Abnormality of chromosome stability (HP:0003220)2.81997984
62Keratoconjunctivitis sicca (HP:0001097)2.78343702
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.76683304
64Abnormal spermatogenesis (HP:0008669)2.76300364
65Myocardial infarction (HP:0001658)2.76035391
66Megaloblastic anemia (HP:0001889)2.73504685
67Neurofibrillary tangles (HP:0002185)2.73294938
68Entropion (HP:0000621)2.73087656
69Sparse eyelashes (HP:0000653)2.69394680
70Congenital, generalized hypertrichosis (HP:0004540)2.68920777
71Axonal loss (HP:0003447)2.68652047
72Hyperglycinuria (HP:0003108)2.66937284
73Agnosia (HP:0010524)2.66604974
74Cerebral hypomyelination (HP:0006808)2.66399515
75Hyperglycinemia (HP:0002154)2.64686806
76Meningitis (HP:0001287)2.61298168
77Hepatosplenomegaly (HP:0001433)2.60235278
78Prolonged bleeding time (HP:0003010)2.59120963
79Urticaria (HP:0001025)2.58610806
80Keratoconjunctivitis (HP:0001096)2.54810921
81Elevated erythrocyte sedimentation rate (HP:0003565)2.54213543
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53773252
83Increased serum ferritin (HP:0003281)2.53327245
84Pulmonary infiltrates (HP:0002113)2.52751999
85Amyloidosis (HP:0011034)2.52668645
86T lymphocytopenia (HP:0005403)2.48607391
87Hematochezia (HP:0002573)2.48160907
88Epistaxis (HP:0000421)2.46773255
89Gingival bleeding (HP:0000225)2.45888460
90Hemoptysis (HP:0002105)2.44500342
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43325479
92Encephalitis (HP:0002383)2.41363934
93Vasculitis (HP:0002633)2.41147982
94Upper motor neuron abnormality (HP:0002127)2.39984305
95Prolonged neonatal jaundice (HP:0006579)2.38503796
96Triphalangeal thumb (HP:0001199)2.37844617
97Recurrent cutaneous fungal infections (HP:0011370)2.36949978
98Chronic mucocutaneous candidiasis (HP:0002728)2.36949978
99Inappropriate behavior (HP:0000719)2.36233543
100Abnormality of the umbilical cord (HP:0010881)2.35900865
101Gastrointestinal infarctions (HP:0005244)2.35552500
102Absent radius (HP:0003974)2.35403934
103Abnormality of secondary sexual hair (HP:0009888)2.34453937
104Abnormality of the axillary hair (HP:0100134)2.34453937
105Neuronal loss in central nervous system (HP:0002529)2.29902573
106Pallor (HP:0000980)2.29709509
107Aplasia involving forearm bones (HP:0009822)2.29329366
108Absent forearm bone (HP:0003953)2.29329366
109Duplicated collecting system (HP:0000081)2.28978139
110Abnormality of T cell number (HP:0011839)2.27455322
111Abnormality of iron homeostasis (HP:0011031)2.27197593
112Duodenal stenosis (HP:0100867)2.26787411
113Small intestinal stenosis (HP:0012848)2.26787411
114Secondary amenorrhea (HP:0000869)2.26411140
115Abnormality of the anterior horn cell (HP:0006802)2.25746782
116Degeneration of anterior horn cells (HP:0002398)2.25746782
117Progressive neurologic deterioration (HP:0002344)2.25568679
118Pustule (HP:0200039)2.21533747
119Myelodysplasia (HP:0002863)2.20445514
120Microretrognathia (HP:0000308)2.20255342
121Azoospermia (HP:0000027)2.19601340
122Horseshoe kidney (HP:0000085)2.17395814
123Absent thumb (HP:0009777)2.17305060
124Abnormality of the renal collecting system (HP:0004742)2.17240539
125Diminished motivation (HP:0000745)2.16737068
126Apathy (HP:0000741)2.16733392
127Type I transferrin isoform profile (HP:0003642)2.16547251
128Death in infancy (HP:0001522)2.16309944
129Polyneuropathy (HP:0001271)2.16107498
130Pulmonary embolism (HP:0002204)2.16093050
131Clubbing of toes (HP:0100760)2.14653971
132Premature ovarian failure (HP:0008209)2.13796411
133Aplasia/hypoplasia of the uterus (HP:0008684)2.13351041
134Complement deficiency (HP:0004431)2.13098086
135Recurrent viral infections (HP:0004429)2.11863583
136Arterial thrombosis (HP:0004420)2.11200324
137Split foot (HP:0001839)2.08411788
138Cerebral inclusion bodies (HP:0100314)2.08107741
139Premature graying of hair (HP:0002216)2.06219484
140Pathologic fracture (HP:0002756)2.05510085
141Conjunctival telangiectasia (HP:0000524)2.04108210
142Pancytopenia (HP:0001876)2.04100210
143Cellulitis (HP:0100658)2.03700414
144Leukocytosis (HP:0001974)2.02178305
145Zonular cataract (HP:0010920)2.02063595
146Anorexia (HP:0002039)1.97585683
147IgM deficiency (HP:0002850)1.97485004
148Reduced antithrombin III activity (HP:0001976)1.97344005
149Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97231290
150Basal ganglia calcification (HP:0002135)1.96573131
151Osteomyelitis (HP:0002754)1.95830718
152Abnormality of serine family amino acid metabolism (HP:0010894)1.95544558
153Abnormality of glycine metabolism (HP:0010895)1.95544558
154Pancreatic fibrosis (HP:0100732)1.95203021
155Increased IgM level (HP:0003496)1.95076535
156Increased IgE level (HP:0003212)1.94848304
157Episodic fever (HP:0001954)1.94093233
158Capillary hemangiomas (HP:0005306)1.93823277
159Pancreatic cysts (HP:0001737)1.91654949
160Personality changes (HP:0000751)1.91185962
161Dementia (HP:0000726)1.90767136
162Chest pain (HP:0100749)1.90389755
163Peripheral demyelination (HP:0011096)1.90358578
164Gangrene (HP:0100758)1.89721260
165Short thumb (HP:0009778)1.89281008
166Nuclear cataract (HP:0100018)1.89121182
167Increased CSF protein (HP:0002922)1.88824658
168Vertigo (HP:0002321)1.88642385
169Abnormality of transition element cation homeostasis (HP:0011030)1.88072471
170Microvesicular hepatic steatosis (HP:0001414)1.87935265
171Abnormal delayed hypersensitivity skin test (HP:0002963)1.86651031
172Abnormality of serum amino acid levels (HP:0003112)1.86285834
173Memory impairment (HP:0002354)1.85471882
174Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85437377
175Type 2 muscle fiber atrophy (HP:0003554)1.84801211
176Neoplasm of the pancreas (HP:0002894)1.83835921
177Hypoplasia of the radius (HP:0002984)1.82882137
178Muscle fiber atrophy (HP:0100295)1.80367712
179Abnormality of alanine metabolism (HP:0010916)1.80317620
180Hyperalaninemia (HP:0003348)1.80317620
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80317620
182Tracheoesophageal fistula (HP:0002575)1.78053259
183CNS hypomyelination (HP:0003429)1.77229134
184Abnormality of DNA repair (HP:0003254)1.76411844
185Cellular immunodeficiency (HP:0005374)1.75194327
186Abnormality of the duodenum (HP:0002246)1.74962149
187Vacuolated lymphocytes (HP:0001922)1.73975291
188Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72596006
189Stenosis of the external auditory canal (HP:0000402)1.72550435
190Multiple enchondromatosis (HP:0005701)1.72145020
191Abnormality of male internal genitalia (HP:0000022)1.71581250
192Irregular epiphyses (HP:0010582)1.71576050
193Stillbirth (HP:0003826)1.71572433
194Abnormality of the prostate (HP:0008775)1.71542333
195Abnormality of the labia minora (HP:0012880)1.71396765
196Absent hand (HP:0004050)1.71373323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE15.02823514
2BUB14.81151840
3RIPK44.27429537
4STK163.94383099
5EIF2AK13.40616544
6SRPK12.69645140
7CSK2.58699446
8PLK42.58289853
9IRAK32.55266168
10TSSK62.54750573
11MAP3K142.45412307
12FGR2.38916020
13MAP4K12.35324205
14NME22.34022091
15MKNK22.27269020
16ZAK2.22410570
17EIF2AK32.19568946
18BRSK22.15344941
19TTK2.11759817
20EPHA22.09440280
21ACVR1B2.02977863
22MKNK11.98984568
23ERN11.98360095
24DYRK31.96818317
25NEK21.93149493
26FES1.91737950
27ZAP701.91689361
28TBK11.87654618
29MAP3K111.87296741
30TAOK11.83475920
31PRPF4B1.79567048
32PIM21.77542592
33PLK11.77276035
34SYK1.65514460
35JAK31.64673407
36VRK11.63357633
37EIF2AK21.58882676
38CAMKK21.56265009
39PLK31.55029701
40IKBKE1.53449547
41TNK21.50539668
42CCNB11.47151510
43MAP3K131.46452963
44AKT31.45894590
45BTK1.39310861
46JAK21.36452845
47HCK1.36310452
48JAK11.27998812
49BLK1.26478665
50MAP3K11.26426204
51AURKB1.25072331
52TAOK31.24734931
53BMPR21.23147826
54CHEK21.20346883
55PDK21.19233504
56STK38L1.17484239
57BRSK11.16616213
58CDC71.16158239
59MARK31.15825053
60IRAK21.13853642
61CDK71.10095685
62RPS6KB21.05829138
63GRK61.04499245
64CAMK1D1.04421318
65NEK11.03233578
66ATR1.02773939
67DDR21.02445181
68AURKA1.01675165
69LCK0.97789834
70EPHB10.96618823
71PIM10.96475464
72RPS6KA40.92875437
73KSR20.91974681
74MAP3K50.90787973
75IRAK40.89464394
76CDC42BPA0.89324445
77SIK30.88505692
78TESK20.86432799
79CDK30.85430318
80STK40.84210234
81MAP3K30.84165553
82KIT0.82379503
83NUAK10.82248410
84PNCK0.82181976
85BRAF0.81787705
86NME10.80144956
87STK30.79868943
88TLK10.79859739
89MOS0.76798744
90PDK10.75949377
91PRKCI0.75937854
92PDPK10.75010816
93YES10.73391842
94STK240.73333686
95PINK10.72471753
96MST40.72405160
97ITK0.70828872
98DAPK20.70636110
99IKBKB0.66633491
100MAP3K20.64566673
101RIPK10.62642791
102CHEK10.60202193
103CSNK2A10.58083900
104MAP3K60.57697864
105EPHA30.57493288
106TIE10.57056846
107CDK40.56604752
108TEC0.56375149
109GRK10.54881904
110MAP3K80.54658068
111KSR10.54411587
112CDK80.54178846
113CDK60.51919525
114NEK90.51848452
115CSNK2A20.51828270
116FYN0.51155471
117ARAF0.50355811
118MARK20.49766600
119MAPK120.49723564
120ADRBK20.49256198
121BMPR1B0.49104743
122PDK30.48990095
123PDK40.48990095
124CAMK1G0.48828525
125TXK0.48199960
126DYRK20.47342770
127RPS6KA50.47153295
128SGK30.46641092
129BMX0.46524362
130TNIK0.45826597
131CHUK0.45158120
132CDK20.44922740
133TAOK20.44455240
134PIK3CG0.43861608
135NEK60.43543084
136TGFBR10.43199497
137CAMKK10.42808408
138ABL20.41894378
139RPS6KC10.41876336
140RPS6KL10.41876336
141ABL10.40978997
142CSF1R0.40408461
143MAPK70.38087737
144PAK10.37211691
145TYK20.36775160
146MAP2K30.36484499
147KDR0.34831996
148TGFBR20.34375198
149CDK10.34076787
150RPS6KA60.33809815
151STK100.33799814
152ATM0.33792243
153MAP2K60.33261292
154MAP2K20.33094763
155GRK70.32955199
156LYN0.32409902
157PRKCQ0.32337306
158PASK0.30002978
159SGK20.29640726
160MAPKAPK20.29413268
161WNK30.28438108
162BCKDK0.28415351
163MAPKAPK30.28340455
164PTK2B0.28063693
165PAK40.27935646
166PRKCD0.27782019
167IRAK10.27357239
168FGFR30.26804220
169MAP2K40.26280452
170RPS6KA20.26096482
171MATK0.25694654
172PRKG20.25038748

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.55748623
2Vitamin B6 metabolism_Homo sapiens_hsa007504.22116094
3Proteasome_Homo sapiens_hsa030503.78538698
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76469644
5Staphylococcus aureus infection_Homo sapiens_hsa051503.58873545
6Ribosome_Homo sapiens_hsa030103.58226091
7DNA replication_Homo sapiens_hsa030303.40614139
8Osteoclast differentiation_Homo sapiens_hsa043803.03391540
9Leishmaniasis_Homo sapiens_hsa051402.90670921
10Mismatch repair_Homo sapiens_hsa034302.85942103
11Pyrimidine metabolism_Homo sapiens_hsa002402.73471297
12Homologous recombination_Homo sapiens_hsa034402.70695038
13RNA transport_Homo sapiens_hsa030132.64301257
14Spliceosome_Homo sapiens_hsa030402.57885069
15Basal transcription factors_Homo sapiens_hsa030222.44558973
16Fanconi anemia pathway_Homo sapiens_hsa034602.44048104
17Tuberculosis_Homo sapiens_hsa051522.40640270
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39070696
19Nucleotide excision repair_Homo sapiens_hsa034202.34007321
20Allograft rejection_Homo sapiens_hsa053302.30585005
21Cell cycle_Homo sapiens_hsa041102.21874531
22Graft-versus-host disease_Homo sapiens_hsa053322.17316652
23Base excision repair_Homo sapiens_hsa034102.15947814
24Malaria_Homo sapiens_hsa051442.13234678
25Phagosome_Homo sapiens_hsa041452.02025315
26Regulation of autophagy_Homo sapiens_hsa041402.02009306
27Autoimmune thyroid disease_Homo sapiens_hsa053202.00604925
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89665152
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78462194
30Purine metabolism_Homo sapiens_hsa002301.75048232
31p53 signaling pathway_Homo sapiens_hsa041151.72525692
32Pertussis_Homo sapiens_hsa051331.71331149
33B cell receptor signaling pathway_Homo sapiens_hsa046621.66228019
34Vitamin digestion and absorption_Homo sapiens_hsa049771.60339169
35Folate biosynthesis_Homo sapiens_hsa007901.59725859
36Type I diabetes mellitus_Homo sapiens_hsa049401.59548922
37* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58618302
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58473459
39Toxoplasmosis_Homo sapiens_hsa051451.51417401
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45045306
41TNF signaling pathway_Homo sapiens_hsa046681.45016953
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40714106
43Pentose phosphate pathway_Homo sapiens_hsa000301.39703235
44Chemokine signaling pathway_Homo sapiens_hsa040621.38899850
45Collecting duct acid secretion_Homo sapiens_hsa049661.36907288
46Salmonella infection_Homo sapiens_hsa051321.34671102
47Non-homologous end-joining_Homo sapiens_hsa034501.32291803
48Arachidonic acid metabolism_Homo sapiens_hsa005901.29682480
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28523557
50RNA degradation_Homo sapiens_hsa030181.27368871
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24623399
52Viral myocarditis_Homo sapiens_hsa054161.18347364
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17612072
54Epstein-Barr virus infection_Homo sapiens_hsa051691.17041926
55One carbon pool by folate_Homo sapiens_hsa006701.13822595
56Other glycan degradation_Homo sapiens_hsa005111.09063009
57Complement and coagulation cascades_Homo sapiens_hsa046101.06024175
58African trypanosomiasis_Homo sapiens_hsa051431.04963277
59Glutathione metabolism_Homo sapiens_hsa004801.03997904
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.00347227
61Acute myeloid leukemia_Homo sapiens_hsa052211.00174523
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00007132
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99933165
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99575708
65T cell receptor signaling pathway_Homo sapiens_hsa046600.97491349
66Sphingolipid metabolism_Homo sapiens_hsa006000.97268811
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.96905965
68Platelet activation_Homo sapiens_hsa046110.94481492
69Shigellosis_Homo sapiens_hsa051310.89188756
70Hepatitis C_Homo sapiens_hsa051600.88005923
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85345205
72Hepatitis B_Homo sapiens_hsa051610.85317731
73mRNA surveillance pathway_Homo sapiens_hsa030150.84628589
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83864921
75Renin-angiotensin system_Homo sapiens_hsa046140.79211252
76Herpes simplex infection_Homo sapiens_hsa051680.76750858
77Fructose and mannose metabolism_Homo sapiens_hsa000510.76635829
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.76354988
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75025597
80Amoebiasis_Homo sapiens_hsa051460.72252602
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.70285512
82Prion diseases_Homo sapiens_hsa050200.70215257
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.69724021
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.69539889
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67294378
86Antigen processing and presentation_Homo sapiens_hsa046120.66865068
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65430223
88Lysosome_Homo sapiens_hsa041420.64001695
89Oocyte meiosis_Homo sapiens_hsa041140.62657421
90Linoleic acid metabolism_Homo sapiens_hsa005910.61202214
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.59993445
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.59599610
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59052060
94Endocytosis_Homo sapiens_hsa041440.58846622
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58032223
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57073725
97VEGF signaling pathway_Homo sapiens_hsa043700.56759740
98Prolactin signaling pathway_Homo sapiens_hsa049170.55388307
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54898288
100Mineral absorption_Homo sapiens_hsa049780.53486632
101Metabolic pathways_Homo sapiens_hsa011000.53473458
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53355782
103Pancreatic cancer_Homo sapiens_hsa052120.51456767
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51230892
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.50311027
106Vibrio cholerae infection_Homo sapiens_hsa051100.48617193
107Bladder cancer_Homo sapiens_hsa052190.47655898
108HIF-1 signaling pathway_Homo sapiens_hsa040660.46752267
109Renal cell carcinoma_Homo sapiens_hsa052110.46111656
110Non-small cell lung cancer_Homo sapiens_hsa052230.45699490
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45089192
112Hematopoietic cell lineage_Homo sapiens_hsa046400.43487920
113Ether lipid metabolism_Homo sapiens_hsa005650.42311129
114Sulfur relay system_Homo sapiens_hsa041220.41897368
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.41753491
116Chronic myeloid leukemia_Homo sapiens_hsa052200.40794691
117Protein export_Homo sapiens_hsa030600.40649653
118PPAR signaling pathway_Homo sapiens_hsa033200.40382612
119Huntingtons disease_Homo sapiens_hsa050160.40359472
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.40124810
121Galactose metabolism_Homo sapiens_hsa000520.39804239
122Legionellosis_Homo sapiens_hsa051340.38868546
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.38613217
124Circadian rhythm_Homo sapiens_hsa047100.36824367
125Systemic lupus erythematosus_Homo sapiens_hsa053220.36777623
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36541742
127Type II diabetes mellitus_Homo sapiens_hsa049300.35932616
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35821140
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35778118
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.35426015
131Dorso-ventral axis formation_Homo sapiens_hsa043200.34652786
132GnRH signaling pathway_Homo sapiens_hsa049120.33517690
133Viral carcinogenesis_Homo sapiens_hsa052030.32160253
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32117549
135Arginine and proline metabolism_Homo sapiens_hsa003300.30486297
136Notch signaling pathway_Homo sapiens_hsa043300.30359765
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29938346
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29328138
139Primary immunodeficiency_Homo sapiens_hsa053400.28359746
140Small cell lung cancer_Homo sapiens_hsa052220.27375957
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26442529
142Biosynthesis of amino acids_Homo sapiens_hsa012300.25162551
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24884985
144Retinol metabolism_Homo sapiens_hsa008300.24795710
145Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24134427
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24011628
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23459912
148Apoptosis_Homo sapiens_hsa042100.23452539
149Measles_Homo sapiens_hsa051620.23113104
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22989250
151Influenza A_Homo sapiens_hsa051640.21145300
152HTLV-I infection_Homo sapiens_hsa051660.20854041
153beta-Alanine metabolism_Homo sapiens_hsa004100.20319813
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19456683
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18351612
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17659237
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16412297
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.16105471
159Rheumatoid arthritis_Homo sapiens_hsa053230.14551296
160Phototransduction_Homo sapiens_hsa047440.12385144
161Asthma_Homo sapiens_hsa053100.12111937
162Oxidative phosphorylation_Homo sapiens_hsa001900.08976410
163SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08338529
164FoxO signaling pathway_Homo sapiens_hsa040680.07127524

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »