NPLOC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.57518668
2proline metabolic process (GO:0006560)5.86953604
3embryonic process involved in female pregnancy (GO:0060136)5.61727508
4negative regulation of fatty acid biosynthetic process (GO:0045717)5.11798606
5regulation of translational fidelity (GO:0006450)5.06636703
6regulation of integrin activation (GO:0033623)5.04154886
7transcription from mitochondrial promoter (GO:0006390)4.95472261
8establishment of apical/basal cell polarity (GO:0035089)4.77795316
9positive regulation of protein homooligomerization (GO:0032464)4.35576587
10mitotic G1 DNA damage checkpoint (GO:0031571)4.34231029
11sulfur amino acid catabolic process (GO:0000098)4.24063822
12mitochondrial DNA metabolic process (GO:0032042)4.18171485
13regulation of protein homooligomerization (GO:0032462)4.14539079
14embryonic placenta development (GO:0001892)3.99570270
15establishment or maintenance of monopolar cell polarity (GO:0061339)3.99040412
16establishment of monopolar cell polarity (GO:0061162)3.99040412
17glutamine family amino acid biosynthetic process (GO:0009084)3.98221537
18cell-substrate adherens junction assembly (GO:0007045)3.96931261
19focal adhesion assembly (GO:0048041)3.96931261
20mitotic G1/S transition checkpoint (GO:0044819)3.96551480
21mannose metabolic process (GO:0006013)3.96236721
22Golgi transport vesicle coating (GO:0048200)3.94241668
23COPI coating of Golgi vesicle (GO:0048205)3.94241668
24adherens junction assembly (GO:0034333)3.90100434
25oxidative demethylation (GO:0070989)3.82375618
26protein localization to endosome (GO:0036010)3.80014145
27replication fork processing (GO:0031297)3.78850410
28G1 DNA damage checkpoint (GO:0044783)3.78232020
29cell-substrate junction assembly (GO:0007044)3.75034856
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.70791953
31regulation of cholesterol homeostasis (GO:2000188)3.69936213
32apoptotic process involved in morphogenesis (GO:0060561)3.55505256
33negative regulation of cell size (GO:0045792)3.48981344
34regulation of RNA export from nucleus (GO:0046831)3.47513583
35negative regulation of fatty acid metabolic process (GO:0045922)3.45179554
36mRNA cleavage (GO:0006379)3.43105061
37negative regulation of fatty acid transport (GO:2000192)3.41161025
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34490890
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.34490890
40basement membrane organization (GO:0071711)3.29783940
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.29782581
42regulation of glucose import in response to insulin stimulus (GO:2001273)3.27517450
43regulation of hippo signaling (GO:0035330)3.26087197
44heterochromatin organization (GO:0070828)3.23480802
45positive regulation of protein oligomerization (GO:0032461)3.22470133
46very-low-density lipoprotein particle assembly (GO:0034379)3.21816541
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19815310
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.19815310
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19815310
50dosage compensation (GO:0007549)3.16854544
51pinocytosis (GO:0006907)3.15673168
52trophectodermal cell differentiation (GO:0001829)3.13270791
53regulation of sister chromatid cohesion (GO:0007063)3.09787701
54labyrinthine layer development (GO:0060711)3.07875940
55poly(A)+ mRNA export from nucleus (GO:0016973)3.07758283
56negative regulation of erythrocyte differentiation (GO:0045647)3.05306214
57regulation of histone H3-K27 methylation (GO:0061085)3.05102434
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05045227
59glyoxylate metabolic process (GO:0046487)3.03884954
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02309542
61nuclear pore complex assembly (GO:0051292)2.98941664
62hemidesmosome assembly (GO:0031581)2.98799951
634-hydroxyproline metabolic process (GO:0019471)2.98206577
64intestinal cholesterol absorption (GO:0030299)2.97373635
65negative regulation of viral release from host cell (GO:1902187)2.96432185
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.94662019
67alkaloid metabolic process (GO:0009820)2.93930588
68regulation of posttranscriptional gene silencing (GO:0060147)2.93526565
69regulation of gene silencing by miRNA (GO:0060964)2.93526565
70regulation of gene silencing by RNA (GO:0060966)2.93526565
71anatomical structure regression (GO:0060033)2.93469692
72glucocorticoid receptor signaling pathway (GO:0042921)2.92258751
73positive regulation of histone deacetylation (GO:0031065)2.91983223
74semaphorin-plexin signaling pathway (GO:0071526)2.91862861
75low-density lipoprotein particle clearance (GO:0034383)2.90524075
76mitotic chromosome condensation (GO:0007076)2.89996521
77alpha-linolenic acid metabolic process (GO:0036109)2.89444554
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.88170568
79cellular response to ATP (GO:0071318)2.87479143
80maternal placenta development (GO:0001893)2.86635084
81embryonic camera-type eye development (GO:0031076)2.86362252
82regulation of protein polyubiquitination (GO:1902914)2.85985382
83positive regulation of receptor recycling (GO:0001921)2.85298847
84negative regulation of cell cycle arrest (GO:0071157)2.84314149
85regulation of protein oligomerization (GO:0032459)2.84293634
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.83443034
87L-phenylalanine metabolic process (GO:0006558)2.82749820
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82749820
89formation of translation preinitiation complex (GO:0001731)2.82036634
90triglyceride homeostasis (GO:0070328)2.80990404
91acylglycerol homeostasis (GO:0055090)2.80990404
92acetyl-CoA metabolic process (GO:0006084)2.80616473
93stress fiber assembly (GO:0043149)2.80380526
94regulation of nucleobase-containing compound transport (GO:0032239)2.79127537
95fatty acid transmembrane transport (GO:1902001)2.78736649
96serine family amino acid catabolic process (GO:0009071)2.78592420
97pre-miRNA processing (GO:0031054)2.78317366
98carnitine shuttle (GO:0006853)2.77981157
99regulation of podosome assembly (GO:0071801)2.77639955
100negative regulation of JAK-STAT cascade (GO:0046426)2.77468788
101negative regulation of protein oligomerization (GO:0032460)2.77325088
102regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76409269
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.74777136
104regulation of translational elongation (GO:0006448)2.74727713
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74515420
106epithelial cell-cell adhesion (GO:0090136)2.74256018
107negative regulation of Ras GTPase activity (GO:0034261)2.72649372
108regulation of fatty acid beta-oxidation (GO:0031998)2.72031988
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.70673636
110heme transport (GO:0015886)2.70015912
111desmosome organization (GO:0002934)2.68218157
112positive regulation of chromosome segregation (GO:0051984)2.68125454
113regulation of cell size (GO:0008361)2.67814313
114regulation of necroptotic process (GO:0060544)2.67058207
115cysteine metabolic process (GO:0006534)2.66913626
116cytolysis (GO:0019835)2.66027905
117snRNA metabolic process (GO:0016073)2.65796499
118anterior/posterior axis specification, embryo (GO:0008595)2.65602088
119regulation of NFAT protein import into nucleus (GO:0051532)2.64865447
120glycine metabolic process (GO:0006544)2.64702069
121positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.64153368
122activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62930831
123folic acid-containing compound biosynthetic process (GO:0009396)2.61723237
124cellular response to virus (GO:0098586)2.61621301
125modulation by symbiont of host cellular process (GO:0044068)2.61404917
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61271642
127negative regulation of fibrinolysis (GO:0051918)2.60964587
128regulation of early endosome to late endosome transport (GO:2000641)2.60589185
129base-excision repair (GO:0006284)2.58317989
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56546649
131convergent extension (GO:0060026)2.54921392
132skin morphogenesis (GO:0043589)2.54329803
133regulation of fatty acid biosynthetic process (GO:0042304)2.54070025
134striated muscle atrophy (GO:0014891)2.53688186
135receptor catabolic process (GO:0032801)2.53552041
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52961560
137barbed-end actin filament capping (GO:0051016)2.50853139
138skeletal muscle adaptation (GO:0043501)2.50220609
139positive regulation of nuclease activity (GO:0032075)2.49587824
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48749146
141DNA strand renaturation (GO:0000733)2.48369400
142plasma lipoprotein particle assembly (GO:0034377)2.46546709
143negative regulation of necroptotic process (GO:0060546)2.46111598
144activation of Rac GTPase activity (GO:0032863)2.45939293
145corticosteroid receptor signaling pathway (GO:0031958)2.45574029
146positive regulation by host of viral transcription (GO:0043923)2.44225626
147negative regulation of myotube differentiation (GO:0010832)2.43597777
148protein-lipid complex assembly (GO:0065005)2.43228514
149urea cycle (GO:0000050)2.42637834
150urea metabolic process (GO:0019627)2.42637834
151lysine metabolic process (GO:0006553)2.42208352
152lysine catabolic process (GO:0006554)2.42208352
153serine family amino acid metabolic process (GO:0009069)2.41643122
154endoplasmic reticulum unfolded protein response (GO:0030968)2.38921658
155regulation of translational termination (GO:0006449)2.38523936
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38410901
157peptidyl-lysine dimethylation (GO:0018027)2.37555719
158positive regulation of protein deacetylation (GO:0090312)2.36906964
1593-UTR-mediated mRNA stabilization (GO:0070935)2.36405874
160positive regulation of protein dephosphorylation (GO:0035307)2.34246085
161membrane protein ectodomain proteolysis (GO:0006509)2.32836684
162NIK/NF-kappaB signaling (GO:0038061)2.32372955
163intracellular estrogen receptor signaling pathway (GO:0030520)2.31424243
164positive regulation of myotube differentiation (GO:0010831)2.30163499
165ER-nucleus signaling pathway (GO:0006984)2.29123841
166cell adhesion mediated by integrin (GO:0033627)2.28864647
167snRNA processing (GO:0016180)2.28111785
168protein hydroxylation (GO:0018126)2.27955813
169response to laminar fluid shear stress (GO:0034616)2.27785320
170protein retention in ER lumen (GO:0006621)2.27106057
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26906529
172nuclear pore organization (GO:0006999)2.24617850
173pore complex assembly (GO:0046931)2.22344237
174regulation of nuclease activity (GO:0032069)2.21603972
175hypotonic response (GO:0006971)2.19665753
176histone H3-K36 demethylation (GO:0070544)2.19241471
177intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.18831110
178cellular response to unfolded protein (GO:0034620)2.18437920
179regulation of chromatin binding (GO:0035561)2.17886170
180activation of MAPKKK activity (GO:0000185)2.16643400
181dicarboxylic acid biosynthetic process (GO:0043650)2.16129368
182pentose-phosphate shunt (GO:0006098)2.15626165
183modulation by virus of host process (GO:0019054)2.15492672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.03924066
2RXR_22158963_ChIP-Seq_LIVER_Mouse2.85118761
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64440288
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57505021
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54628775
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43663716
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.36436504
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.34338617
9E2F7_22180533_ChIP-Seq_HELA_Human2.25899839
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.20252766
11VDR_21846776_ChIP-Seq_THP-1_Human2.18341386
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14536722
13ZNF263_19887448_ChIP-Seq_K562_Human2.12276440
14MYC_22102868_ChIP-Seq_BL_Human2.04031370
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.00009209
16STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99280541
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96390943
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96390943
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96390943
20LXR_22292898_ChIP-Seq_THP-1_Human1.96249805
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91716626
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88343788
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86981272
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85513296
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82058902
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.80757918
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78900127
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.78245384
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77982895
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76802094
31RACK7_27058665_Chip-Seq_MCF-7_Human1.72672476
32KDM2B_26808549_Chip-Seq_DND41_Human1.68619780
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.64451479
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.64198759
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61593724
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60719978
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.58519712
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56970771
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.56331358
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54996861
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54949333
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53735932
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53452248
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52272957
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52143726
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.51602522
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49626960
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48304540
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47772757
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46624794
51VDR_24763502_ChIP-Seq_THP-1_Human1.45824660
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45431669
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44632137
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44041761
55TCF7_22412390_ChIP-Seq_EML_Mouse1.43863267
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42375612
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42046679
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41959649
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41340845
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39697029
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.39629413
62P68_20966046_ChIP-Seq_HELA_Human1.37802484
63* ATF3_27146783_Chip-Seq_COLON_Human1.37261905
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36592523
65SMC4_20622854_ChIP-Seq_HELA_Human1.35581038
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35246457
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33778798
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33619875
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32981658
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31413910
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26499941
72UBF1/2_26484160_Chip-Seq_HMECs_Human1.25609770
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.25209090
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24773528
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.24469431
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24056037
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24038377
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23246821
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23083278
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.23039818
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21635684
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20232350
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20228975
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19744848
85MAF_26560356_Chip-Seq_TH2_Human1.19488661
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19412172
87CLOCK_20551151_ChIP-Seq_293T_Human1.19111675
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18311379
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.16734000
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15989530
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14645107
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14578659
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.14181857
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13818883
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13714540
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13670040
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11977357
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.11426541
99RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11213492
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10953142
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10602427
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10422086
103* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09850164
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09652551
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09455122
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08545212
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08332923
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08143406
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06892083
110MAF_26560356_Chip-Seq_TH1_Human1.06567476
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06270455
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06270455
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05301812
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05049433
115CREB1_26743006_Chip-Seq_LNCaP_Human1.04968501
116* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04465049
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04248479
118TBX20_22080862_ChIP-Seq_HEART_Mouse1.03847040
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.03847040
120NCOR1_26117541_ChIP-Seq_K562_Human1.03610368
121BCOR_27268052_Chip-Seq_Bcells_Human1.03486430
122KDM5A_27292631_Chip-Seq_BREAST_Human1.02961536
123KDM2B_26808549_Chip-Seq_K562_Human1.02616973
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.02324039
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02105290
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.01752388
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.01629847
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01442552
129GATA1_19941826_ChIP-Seq_K562_Human1.01300635
130P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01263473
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00989223
132TP53_22127205_ChIP-Seq_IMR90_Human1.00712904
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00335120
134MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98758944
135* CHD1_26751641_Chip-Seq_LNCaP_Human0.98543118
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.98371274
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98321112
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98178668
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98098056
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97712141
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97186693
142UTX_26944678_Chip-Seq_JUKART_Human0.96977308
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.96730687
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96551842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.66856048
2MP0003705_abnormal_hypodermis_morpholog3.45792528
3MP0009278_abnormal_bone_marrow3.19894451
4MP0008057_abnormal_DNA_replication3.02643393
5MP0005085_abnormal_gallbladder_physiolo2.93841227
6MP0002139_abnormal_hepatobiliary_system2.92035443
7MP0005365_abnormal_bile_salt2.73065100
8MP0010352_gastrointestinal_tract_polyps2.71403740
9MP0004233_abnormal_muscle_weight2.57714582
10MP0005360_urolithiasis2.47886705
11MP0010030_abnormal_orbit_morphology2.43722871
12MP0005076_abnormal_cell_differentiation2.33778968
13MP0003806_abnormal_nucleotide_metabolis2.19592617
14MP0003091_abnormal_cell_migration1.88761750
15MP0005409_darkened_coat_color1.85843913
16MP0001348_abnormal_lacrimal_gland1.81587198
17MP0009840_abnormal_foam_cell1.77656329
18MP0002877_abnormal_melanocyte_morpholog1.75999536
19MP0002269_muscular_atrophy1.75013835
20MP0005257_abnormal_intraocular_pressure1.74576376
21MP0003453_abnormal_keratinocyte_physiol1.69621762
22MP0000003_abnormal_adipose_tissue1.68911808
23MP0004185_abnormal_adipocyte_glucose1.68623583
24MP0004197_abnormal_fetal_growth/weight/1.64730549
25MP0003890_abnormal_embryonic-extraembry1.59618678
26MP0003566_abnormal_cell_adhesion1.57315564
27MP0002086_abnormal_extraembryonic_tissu1.56771652
28MP0005171_absent_coat_pigmentation1.55625445
29MP0004858_abnormal_nervous_system1.51521307
30MP0003950_abnormal_plasma_membrane1.45488366
31MP0004808_abnormal_hematopoietic_stem1.45302635
32MP0010307_abnormal_tumor_latency1.45154255
33MP0003303_peritoneal_inflammation1.44886476
34MP0008260_abnormal_autophagy1.43162786
35MP0003283_abnormal_digestive_organ1.42415086
36MP0001730_embryonic_growth_arrest1.40982774
37MP0005083_abnormal_biliary_tract1.39847809
38MP0005397_hematopoietic_system_phenotyp1.39481025
39MP0001545_abnormal_hematopoietic_system1.39481025
40MP0002796_impaired_skin_barrier1.38900446
41MP0002084_abnormal_developmental_patter1.38341419
42MP0001697_abnormal_embryo_size1.38170567
43MP0003252_abnormal_bile_duct1.38151932
44MP0004272_abnormal_basement_membrane1.36605294
45MP0005058_abnormal_lysosome_morphology1.35217677
46MP0009053_abnormal_anal_canal1.34197453
47MP0004947_skin_inflammation1.34113821
48MP0005380_embryogenesis_phenotype1.33724471
49MP0001672_abnormal_embryogenesis/_devel1.33724471
50MP0003119_abnormal_digestive_system1.30527593
51MP0001661_extended_life_span1.29807339
52MP0004957_abnormal_blastocyst_morpholog1.29385148
53MP0000609_abnormal_liver_physiology1.26641581
54MP0010094_abnormal_chromosome_stability1.24231310
55MP0002396_abnormal_hematopoietic_system1.22422569
56MP0008995_early_reproductive_senescence1.21754316
57MP0010630_abnormal_cardiac_muscle1.20427936
58MP0010329_abnormal_lipoprotein_level1.19300670
59MP0003567_abnormal_fetal_cardiomyocyte1.19028058
60MP0003984_embryonic_growth_retardation1.19000117
61MP0003279_aneurysm1.18608664
62MP0000858_altered_metastatic_potential1.18416156
63MP0002009_preneoplasia1.18265452
64MP0002085_abnormal_embryonic_tissue1.17802220
65MP0002088_abnormal_embryonic_growth/wei1.17589279
66MP0005023_abnormal_wound_healing1.16962403
67MP0004130_abnormal_muscle_cell1.15862535
68MP0005666_abnormal_adipose_tissue1.14618963
69MP0000579_abnormal_nail_morphology1.13540553
70MP0004087_abnormal_muscle_fiber1.13007585
71MP0002089_abnormal_postnatal_growth/wei1.11929201
72MP0000371_diluted_coat_color1.11422677
73MP0002282_abnormal_trachea_morphology1.10265358
74MP0000015_abnormal_ear_pigmentation1.10004265
75MP0003111_abnormal_nucleus_morphology1.09001581
76MP0003656_abnormal_erythrocyte_physiolo1.07222166
77MP0002060_abnormal_skin_morphology1.06873381
78MP0006138_congestive_heart_failure1.06461138
79MP0005621_abnormal_cell_physiology1.06062757
80MP0005330_cardiomyopathy1.05932581
81MP0009115_abnormal_fat_cell1.05291981
82MP0004381_abnormal_hair_follicle1.05146779
83MP0000350_abnormal_cell_proliferation1.04808088
84MP0003763_abnormal_thymus_physiology1.04339889
85MP0005623_abnormal_meninges_morphology1.03058355
86MP0003436_decreased_susceptibility_to1.01288471
87MP0000767_abnormal_smooth_muscle1.00445697
88MP0004264_abnormal_extraembryonic_tissu1.00372699
89MP0002080_prenatal_lethality1.00192362
90MP0000733_abnormal_muscle_development0.99991173
91MP0003172_abnormal_lysosome_physiology0.98637541
92MP0000678_abnormal_parathyroid_gland0.96431860
93MP0000747_muscle_weakness0.95384809
94MP0003191_abnormal_cellular_cholesterol0.95242577
95MP0003045_fibrosis0.95216943
96MP0001873_stomach_inflammation0.94630310
97MP0004510_myositis0.94168373
98MP0000598_abnormal_liver_morphology0.93610494
99MP0008438_abnormal_cutaneous_collagen0.93048140
100MP0003221_abnormal_cardiomyocyte_apopto0.92095247
101MP0000749_muscle_degeneration0.91811028
102MP0005319_abnormal_enzyme/_coenzyme0.91679717
103MP0001293_anophthalmia0.89857611
104MP0001849_ear_inflammation0.89377275
105MP0002971_abnormal_brown_adipose0.88683593
106MP0000685_abnormal_immune_system0.88135226
107MP0001958_emphysema0.88119105
108MP0001216_abnormal_epidermal_layer0.87546574
109MP0003300_gastrointestinal_ulcer0.87171496
110MP0002118_abnormal_lipid_homeostasis0.87014521
111MP0002075_abnormal_coat/hair_pigmentati0.86715977
112MP0001915_intracranial_hemorrhage0.86578655
113MP0002111_abnormal_tail_morphology0.86148843
114MP0002998_abnormal_bone_remodeling0.86026213
115MP0000750_abnormal_muscle_regeneration0.85964887
116MP0002970_abnormal_white_adipose0.85881289
117MP0002653_abnormal_ependyma_morphology0.85615005
118MP0000013_abnormal_adipose_tissue0.85461532
119MP0003646_muscle_fatigue0.85411201
120MP0005375_adipose_tissue_phenotype0.84926854
121MP0009333_abnormal_splenocyte_physiolog0.84515638
122MP0005332_abnormal_amino_acid0.83279422
123MP0004036_abnormal_muscle_relaxation0.83168492
124MP0005501_abnormal_skin_physiology0.82705460
125MP0002332_abnormal_exercise_endurance0.82315869
126MP0001340_abnormal_eyelid_morphology0.82202809
127MP0008875_abnormal_xenobiotic_pharmacok0.81908008
128MP0009931_abnormal_skin_appearance0.80350973
129MP0003786_premature_aging0.80204120
130MP0005266_abnormal_metabolism0.79629930
131MP0003828_pulmonary_edema0.78819583
132MP0008877_abnormal_DNA_methylation0.78462857
133MP0003077_abnormal_cell_cycle0.78373066
134MP0010234_abnormal_vibrissa_follicle0.78131625
135MP0001666_abnormal_nutrient_absorption0.76951729
136MP0004019_abnormal_vitamin_homeostasis0.76302732
137MP0000751_myopathy0.74876495
138MP0004133_heterotaxia0.74482607
139MP0000639_abnormal_adrenal_gland0.73370096
140MP0005670_abnormal_white_adipose0.72583263
141MP0002019_abnormal_tumor_incidence0.71785841
142MP0005408_hypopigmentation0.71396344
143MP0000759_abnormal_skeletal_muscle0.71296525
144MP0002254_reproductive_system_inflammat0.69813521
145MP0000537_abnormal_urethra_morphology0.69351380
146MP0008932_abnormal_embryonic_tissue0.69284158
147MP0002896_abnormal_bone_mineralization0.68486623
148MP0002925_abnormal_cardiovascular_devel0.67604486
149MP0009672_abnormal_birth_weight0.67355220
150MP0008961_abnormal_basal_metabolism0.66190925

Predicted human phenotypes

RankGene SetZ-score
1Turricephaly (HP:0000262)4.22723516
2Ulnar bowing (HP:0003031)4.09565159
3Alopecia of scalp (HP:0002293)3.80793291
4Male infertility (HP:0003251)3.58867585
5Hypochromic microcytic anemia (HP:0004840)3.55485356
6Cerebral aneurysm (HP:0004944)3.46256430
7Hyperacusis (HP:0010780)3.44375622
8Rib fusion (HP:0000902)3.40381688
9Pustule (HP:0200039)3.37638339
10Facial hemangioma (HP:0000329)3.23433858
11Deep venous thrombosis (HP:0002625)3.20637319
12Premature rupture of membranes (HP:0001788)3.16071879
13Distal lower limb amyotrophy (HP:0008944)3.10495817
14Short humerus (HP:0005792)3.08859515
15Annular pancreas (HP:0001734)3.05233244
16Coronal craniosynostosis (HP:0004440)3.03800468
17Hypobetalipoproteinemia (HP:0003563)3.00777090
18Myocardial infarction (HP:0001658)2.91786721
19Intrahepatic cholestasis (HP:0001406)2.91376851
20Broad face (HP:0000283)2.91079168
21Abnormality of the lower motor neuron (HP:0002366)2.86526174
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76051985
23Aplasia/hypoplasia of the humerus (HP:0006507)2.74938700
24Vaginal fistula (HP:0004320)2.70493212
25Asymmetric septal hypertrophy (HP:0001670)2.69920171
26Rectovaginal fistula (HP:0000143)2.67389347
27Rectal fistula (HP:0100590)2.67389347
28Flat acetabular roof (HP:0003180)2.66125839
29Vertebral compression fractures (HP:0002953)2.65415398
30Xanthomatosis (HP:0000991)2.62442186
31Concave nail (HP:0001598)2.60363449
32Poikiloderma (HP:0001029)2.60309886
33Muscle fibrillation (HP:0010546)2.59967882
34Polycythemia (HP:0001901)2.58756068
35Abnormal hemoglobin (HP:0011902)2.54781557
36Distal lower limb muscle weakness (HP:0009053)2.54106330
37Mucopolysacchariduria (HP:0008155)2.51152769
38Urinary glycosaminoglycan excretion (HP:0003541)2.51152769
39Dysmetric saccades (HP:0000641)2.48556123
40Intestinal fistula (HP:0100819)2.47457490
41Asymmetry of the thorax (HP:0001555)2.42574886
42Exercise-induced myalgia (HP:0003738)2.41810896
43Pancreatic islet-cell hyperplasia (HP:0004510)2.40522050
44Tongue fasciculations (HP:0001308)2.39834719
45Bowed forearm bones (HP:0003956)2.39318821
46Bowing of the arm (HP:0006488)2.39318821
47Back pain (HP:0003418)2.37971063
48Vertebral hypoplasia (HP:0008417)2.37842383
49Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.37842383
50Congenital hip dislocation (HP:0001374)2.36978260
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.36368002
52Difficulty climbing stairs (HP:0003551)2.35374748
53Orthostatic hypotension (HP:0001278)2.34493055
54Hypolipoproteinemia (HP:0010981)2.32967157
55Squamous cell carcinoma (HP:0002860)2.32824418
56Disproportionate tall stature (HP:0001519)2.32014196
57Hyporeflexia of lower limbs (HP:0002600)2.31353120
58Increased connective tissue (HP:0009025)2.30313490
59Spinal rigidity (HP:0003306)2.29503915
60Myoglobinuria (HP:0002913)2.23418762
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22851872
62Large for gestational age (HP:0001520)2.21172479
63Abnormality of the astrocytes (HP:0100707)2.20158204
64Astrocytoma (HP:0009592)2.20158204
65Selective tooth agenesis (HP:0001592)2.19234764
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19085707
67Abnormality of polysaccharide metabolism (HP:0011012)2.19085707
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19085707
69Diaphragmatic weakness (HP:0009113)2.18235408
70Abnormality of the fingertips (HP:0001211)2.17908490
71Hemorrhage of the eye (HP:0011885)2.16902870
72Basal cell carcinoma (HP:0002671)2.16615271
73Increased cerebral lipofuscin (HP:0011813)2.15802329
74Thin bony cortex (HP:0002753)2.15631702
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.15369060
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13300197
77Spastic diplegia (HP:0001264)2.12267464
78Hyperammonemia (HP:0001987)2.12141432
79Vertebral fusion (HP:0002948)2.09771524
80Upper limb amyotrophy (HP:0009129)2.09723795
81Distal upper limb amyotrophy (HP:0007149)2.09723795
82Abnormality of the thoracic spine (HP:0100711)2.09697241
83Pseudobulbar signs (HP:0002200)2.09303162
84Type 1 muscle fiber predominance (HP:0003803)2.08884720
85Cervical subluxation (HP:0003308)2.08298178
86Short nail (HP:0001799)2.08295776
87Fragile skin (HP:0001030)2.06797784
88Metaphyseal cupping (HP:0003021)2.06183222
89Increased mean platelet volume (HP:0011877)2.05179324
90Lower limb amyotrophy (HP:0007210)2.04718885
91Heterotopia (HP:0002282)2.04196323
92Elbow flexion contracture (HP:0002987)2.01648215
93Abnormality of the Achilles tendon (HP:0005109)2.01142860
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.99825960
95Osteolytic defects of the hand bones (HP:0009699)1.99825960
96Myopathic facies (HP:0002058)1.99254259
97Hand muscle atrophy (HP:0009130)1.98528892
98Complement deficiency (HP:0004431)1.97590312
99Increased IgM level (HP:0003496)1.96884276
100Dislocated radial head (HP:0003083)1.96814596
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96751802
102Hypoalphalipoproteinemia (HP:0003233)1.96670944
103Dysostosis multiplex (HP:0000943)1.95484180
104Abnormality of the pancreatic islet cells (HP:0006476)1.95079912
105Abnormality of endocrine pancreas physiology (HP:0012093)1.95079912
106Mildly elevated creatine phosphokinase (HP:0008180)1.94963914
107Ketoacidosis (HP:0001993)1.94826121
108Shallow orbits (HP:0000586)1.93792676
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93691296
110Ankyloglossia (HP:0010296)1.93415868
111Abnormality of oral frenula (HP:0000190)1.92734238
112Blue sclerae (HP:0000592)1.92453324
113Hamartoma (HP:0010566)1.92347876
114Persistence of primary teeth (HP:0006335)1.91801777
115Breast hypoplasia (HP:0003187)1.91226431
116Stridor (HP:0010307)1.90779155
117Increased variability in muscle fiber diameter (HP:0003557)1.90420052
118Ketosis (HP:0001946)1.88650298
119Broad alveolar ridges (HP:0000187)1.88589379
120Hypochromic anemia (HP:0001931)1.88552129
121Bilateral sensorineural hearing impairment (HP:0008619)1.87829134
122Natal tooth (HP:0000695)1.86180223
123Abnormality of skeletal muscle fiber size (HP:0012084)1.85710045
124Sparse lateral eyebrow (HP:0005338)1.85279320
125Long eyelashes (HP:0000527)1.84598618
126EMG: neuropathic changes (HP:0003445)1.82352231
127Wormian bones (HP:0002645)1.81650296
128Long toe (HP:0010511)1.81327695
129Increased CSF protein (HP:0002922)1.81305647
130Achilles tendon contracture (HP:0001771)1.81247455
131Abnormality of complement system (HP:0005339)1.80881510
132Spinal cord lesions (HP:0100561)1.80874101
133Syringomyelia (HP:0003396)1.80874101
134Generalized amyotrophy (HP:0003700)1.80550188
135J-shaped sella turcica (HP:0002680)1.80509834
136Abnormality of the radial head (HP:0003995)1.80154800
137Aneurysm (HP:0002617)1.78946895
138Abnormality of sulfur amino acid metabolism (HP:0004339)1.78718253
139Albinism (HP:0001022)1.78334035
140Hypoplastic ischia (HP:0003175)1.78041574
141Advanced eruption of teeth (HP:0006288)1.77649394
142Abnormality of the aortic arch (HP:0012303)1.77009657
143Long palpebral fissure (HP:0000637)1.76860367
144Short chin (HP:0000331)1.76507125
145Insomnia (HP:0100785)1.74488921
146Hypotrichosis (HP:0001006)1.74395886
147Obstructive sleep apnea (HP:0002870)1.74056254
148Spondylolisthesis (HP:0003302)1.74033431
149Protrusio acetabuli (HP:0003179)1.73907160
150Malnutrition (HP:0004395)1.73763445
151Premature skin wrinkling (HP:0100678)1.73627560
152Abnormality of the calcaneus (HP:0008364)1.73513220
153Abnormality of the distal phalanges of the toes (HP:0010182)1.73364839
154Mitral regurgitation (HP:0001653)1.73001588
155Abnormal platelet volume (HP:0011876)1.72991069
156Bladder diverticulum (HP:0000015)1.71900544
157Ankle contracture (HP:0006466)1.71447447
158Colitis (HP:0002583)1.70232822
159Atrophic scars (HP:0001075)1.69365521
160Ulnar deviation of the wrist (HP:0003049)1.69313930
161Progressive muscle weakness (HP:0003323)1.69182534
162Interstitial pulmonary disease (HP:0006530)1.68398841
163Mitral valve prolapse (HP:0001634)1.67436743
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.66440345
165Aortic aneurysm (HP:0004942)1.66318217
166Patellar dislocation (HP:0002999)1.65335706
167Genu recurvatum (HP:0002816)1.65261169
168Coxa vara (HP:0002812)1.65038671
169Thoracic kyphosis (HP:0002942)1.64985175
170Dilatation of the ascending aorta (HP:0005111)1.64977076
171Abnormal ossification of hand bones (HP:0005921)1.64743661
172Trismus (HP:0000211)1.64467362
173Abnormality of the acetabulum (HP:0003170)1.61365102
174Round ear (HP:0100830)1.60075552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.47495054
2DDR23.84826744
3IRAK33.31061058
4TRIB33.19823405
5SMG13.10178985
6MAP3K63.00282833
7MAP3K112.83922458
8PRPF4B2.59684354
9TYRO32.57943604
10MAPK152.50825307
11EEF2K2.50611535
12PDGFRA2.37622794
13BMX2.36191107
14MST1R2.31107948
15MAP3K102.28421484
16CDK122.06902676
17FGR1.93473961
18PKN21.92106726
19MATK1.89826511
20PINK11.82790742
21CDK61.71158747
22TRPM71.70173736
23LATS21.68941764
24CSK1.66576985
25DYRK1B1.59704342
26TTN1.52822809
27ERN11.48516615
28NME21.42861499
29MAPKAPK31.41331388
30LATS11.40787350
31PRKD21.33278993
32MTOR1.31796655
33TAOK21.30299104
34MAP3K131.28219247
35CDK71.26594031
36RIPK11.24504899
37DAPK11.22299437
38UHMK11.15780991
39MAPK111.15069306
40SIK11.10384229
41KSR21.07182086
42PIM11.05511017
43PIM21.03930897
44NEK11.02603515
45GSK3A1.01406895
46PDPK11.00919354
47RPS6KB20.99716601
48STK30.97799773
49PDK40.97778780
50PDK30.97778780
51EPHA20.96940646
52MAP3K140.94595794
53NEK20.93410378
54PTK60.90953221
55MELK0.89474266
56RPS6KL10.87900308
57RPS6KC10.87900308
58PHKG10.87674286
59PHKG20.87674286
60CDC42BPA0.85650721
61ALK0.84168413
62PRKD30.80984506
63TBK10.79769371
64MAP3K70.78859723
65ZAP700.78100706
66FGFR30.77029200
67MARK20.76959495
68MAP3K10.76529649
69PRKAA10.75437477
70RPS6KA60.75288980
71PDGFRB0.74403520
72RPS6KA10.72399344
73RPS6KA20.70309485
74PTK20.69961447
75CDK40.69881526
76NEK90.69098777
77LMTK20.68415334
78BCKDK0.68381939
79MAP2K20.67907558
80PAK20.67208548
81STK100.65422278
82YES10.65310698
83SCYL20.63559179
84TAOK10.60329897
85IRAK40.59697053
86CHEK20.57769821
87SIK20.57694961
88FLT30.57032098
89TYK20.56842997
90EGFR0.56135822
91NTRK10.55802594
92RET0.55462592
93JAK30.54554480
94PDK10.54231940
95FGFR40.53841228
96IRAK20.53828604
97MAP3K80.52955457
98MAPK120.52702235
99EPHB10.52206149
100PAK40.51062836
101PRKAA20.49197533
102DYRK30.48377722
103PLK10.47964551
104CDC70.47657367
105MAP2K60.46640958
106MAP2K30.46483270
107FGFR10.46476107
108DMPK0.45467556
109CAMK1D0.45352067
110CHEK10.44017603
111MAP2K10.43792599
112MET0.43238324
113BRD40.42667585
114CDK20.41994165
115MAP3K30.41468573
116PDK20.40934564
117HIPK20.40663593
118ERBB40.40650538
119PRKG20.38769815
120TTK0.38226312
121SGK30.37664781
122JAK10.37626907
123JAK20.36368871
124CDK90.36183200
125IRAK10.35868271
126RPS6KB10.35274213
127MAPK10.34827724
128SIK30.32766300
129MARK30.32433075
130PRKD10.32278610
131LRRK20.32151438
132CAMK1G0.31311067
133STK380.31140336
134MAP3K20.30863238
135MAPKAPK20.29127245
136ATR0.28299695
137ATM0.27150921
138MAP4K10.25318097
139CHUK0.24781818
140AKT20.24301457
141MAPK30.23946078

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.27416207
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94483135
3Other glycan degradation_Homo sapiens_hsa005112.63901624
4Arginine biosynthesis_Homo sapiens_hsa002202.63697216
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.48003556
6Nitrogen metabolism_Homo sapiens_hsa009102.39845902
7Fatty acid metabolism_Homo sapiens_hsa012122.34523713
8Biosynthesis of amino acids_Homo sapiens_hsa012302.12686392
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.05273483
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04003552
11Non-small cell lung cancer_Homo sapiens_hsa052231.82381591
12Base excision repair_Homo sapiens_hsa034101.80208595
13Mismatch repair_Homo sapiens_hsa034301.76961871
14Lysine degradation_Homo sapiens_hsa003101.76866232
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75326938
16mTOR signaling pathway_Homo sapiens_hsa041501.74896479
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74682540
18Pancreatic cancer_Homo sapiens_hsa052121.72040465
19Selenocompound metabolism_Homo sapiens_hsa004501.72024848
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64969734
21Fatty acid degradation_Homo sapiens_hsa000711.61447241
22Arginine and proline metabolism_Homo sapiens_hsa003301.57005322
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55013383
24Adherens junction_Homo sapiens_hsa045201.49756867
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42667389
26Tryptophan metabolism_Homo sapiens_hsa003801.41075459
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39582810
28PPAR signaling pathway_Homo sapiens_hsa033201.39556867
29One carbon pool by folate_Homo sapiens_hsa006701.39002966
30B cell receptor signaling pathway_Homo sapiens_hsa046621.29379782
31Renal cell carcinoma_Homo sapiens_hsa052111.28829053
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28351097
33Glioma_Homo sapiens_hsa052141.27883312
34Complement and coagulation cascades_Homo sapiens_hsa046101.24977184
35Bladder cancer_Homo sapiens_hsa052191.24710517
36Carbon metabolism_Homo sapiens_hsa012001.24617503
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23779282
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22559681
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.21932990
40Pyruvate metabolism_Homo sapiens_hsa006201.18163967
41Prostate cancer_Homo sapiens_hsa052151.17929998
42Propanoate metabolism_Homo sapiens_hsa006401.17861898
43Hippo signaling pathway_Homo sapiens_hsa043901.15747452
44TNF signaling pathway_Homo sapiens_hsa046681.15354404
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15083835
46DNA replication_Homo sapiens_hsa030301.14382049
47Sulfur relay system_Homo sapiens_hsa041221.13325584
48RNA transport_Homo sapiens_hsa030131.11638540
49ErbB signaling pathway_Homo sapiens_hsa040121.10349352
50Hepatitis B_Homo sapiens_hsa051611.09960658
51Hepatitis C_Homo sapiens_hsa051601.08980258
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06940278
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05328182
54mRNA surveillance pathway_Homo sapiens_hsa030151.04978235
55Notch signaling pathway_Homo sapiens_hsa043301.04804476
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04177389
57Prion diseases_Homo sapiens_hsa050201.04072056
58Fat digestion and absorption_Homo sapiens_hsa049751.03220197
59ECM-receptor interaction_Homo sapiens_hsa045121.03207614
60Apoptosis_Homo sapiens_hsa042101.02177122
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00587061
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.99802524
63Prolactin signaling pathway_Homo sapiens_hsa049170.99787540
64Toxoplasmosis_Homo sapiens_hsa051450.99725020
65Lysosome_Homo sapiens_hsa041420.99468677
66AMPK signaling pathway_Homo sapiens_hsa041520.97429735
67Chronic myeloid leukemia_Homo sapiens_hsa052200.97354066
68Inositol phosphate metabolism_Homo sapiens_hsa005620.96647955
69Hedgehog signaling pathway_Homo sapiens_hsa043400.95535043
70Influenza A_Homo sapiens_hsa051640.95387446
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.94824222
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.94613696
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92954786
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92663080
75GnRH signaling pathway_Homo sapiens_hsa049120.92531222
76Fructose and mannose metabolism_Homo sapiens_hsa000510.92029994
77Osteoclast differentiation_Homo sapiens_hsa043800.91721035
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.91264765
79Amoebiasis_Homo sapiens_hsa051460.90832560
80Dorso-ventral axis formation_Homo sapiens_hsa043200.90016697
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88904080
82VEGF signaling pathway_Homo sapiens_hsa043700.85656055
83Starch and sucrose metabolism_Homo sapiens_hsa005000.84751050
84Choline metabolism in cancer_Homo sapiens_hsa052310.84065673
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83397016
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81927920
87Small cell lung cancer_Homo sapiens_hsa052220.81888588
88TGF-beta signaling pathway_Homo sapiens_hsa043500.80388734
89p53 signaling pathway_Homo sapiens_hsa041150.78306073
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78187035
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78021611
92Staphylococcus aureus infection_Homo sapiens_hsa051500.77728205
93Insulin signaling pathway_Homo sapiens_hsa049100.77651060
94Viral myocarditis_Homo sapiens_hsa054160.77483770
95Folate biosynthesis_Homo sapiens_hsa007900.76894251
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76849224
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.75824880
98Estrogen signaling pathway_Homo sapiens_hsa049150.75464264
99N-Glycan biosynthesis_Homo sapiens_hsa005100.75126602
100Bile secretion_Homo sapiens_hsa049760.74854674
101HTLV-I infection_Homo sapiens_hsa051660.74765968
102Dilated cardiomyopathy_Homo sapiens_hsa054140.74202974
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73443469
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73112369
105MicroRNAs in cancer_Homo sapiens_hsa052060.72879068
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.72846705
107Insulin resistance_Homo sapiens_hsa049310.72347257
108FoxO signaling pathway_Homo sapiens_hsa040680.71002865
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70497536
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.69786150
111Colorectal cancer_Homo sapiens_hsa052100.69486369
112Measles_Homo sapiens_hsa051620.68314819
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68140147
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.67872917
115Shigellosis_Homo sapiens_hsa051310.66925405
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66879082
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66586155
118HIF-1 signaling pathway_Homo sapiens_hsa040660.65983299
119Proteoglycans in cancer_Homo sapiens_hsa052050.65461074
120Butanoate metabolism_Homo sapiens_hsa006500.65198298
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64563555
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.63479024
123Acute myeloid leukemia_Homo sapiens_hsa052210.62810380
124Glycerolipid metabolism_Homo sapiens_hsa005610.62064536
125Phenylalanine metabolism_Homo sapiens_hsa003600.61624541
126ABC transporters_Homo sapiens_hsa020100.61396097
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61322401
128Melanoma_Homo sapiens_hsa052180.61062800
129Pentose phosphate pathway_Homo sapiens_hsa000300.60790078
130Tight junction_Homo sapiens_hsa045300.59908598
131Viral carcinogenesis_Homo sapiens_hsa052030.59652040
132Steroid biosynthesis_Homo sapiens_hsa001000.59599144
133T cell receptor signaling pathway_Homo sapiens_hsa046600.59280158
134Sphingolipid metabolism_Homo sapiens_hsa006000.59239783
135Basal cell carcinoma_Homo sapiens_hsa052170.59166509
136Platelet activation_Homo sapiens_hsa046110.58610758
137Glucagon signaling pathway_Homo sapiens_hsa049220.58426240
138Peroxisome_Homo sapiens_hsa041460.57426840
139* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57348363
140Focal adhesion_Homo sapiens_hsa045100.56603260
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.54643404
142Pathways in cancer_Homo sapiens_hsa052000.54296069
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.53599485
144Herpes simplex infection_Homo sapiens_hsa051680.52111790
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51541582
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51103000
147Glutathione metabolism_Homo sapiens_hsa004800.50507859
148Endocytosis_Homo sapiens_hsa041440.50245311
149beta-Alanine metabolism_Homo sapiens_hsa004100.49662804
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49298161
151Legionellosis_Homo sapiens_hsa051340.48800980
152Circadian rhythm_Homo sapiens_hsa047100.47611446
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46270789
154Galactose metabolism_Homo sapiens_hsa000520.45989410
155Cell cycle_Homo sapiens_hsa041100.45079617
156Thyroid cancer_Homo sapiens_hsa052160.44666881
157Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44475020
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.43496719
159Endometrial cancer_Homo sapiens_hsa052130.39645732
160Fatty acid elongation_Homo sapiens_hsa000620.38979431

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