NPM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.75618745
2nucleobase biosynthetic process (GO:0046112)4.65537130
3DNA unwinding involved in DNA replication (GO:0006268)4.64246226
4DNA replication initiation (GO:0006270)4.64131050
5formation of translation preinitiation complex (GO:0001731)4.62735680
6maturation of SSU-rRNA (GO:0030490)4.55899477
7mitotic metaphase plate congression (GO:0007080)4.54782566
8DNA strand elongation involved in DNA replication (GO:0006271)4.54742025
9purine nucleobase biosynthetic process (GO:0009113)4.46854664
10nuclear pore complex assembly (GO:0051292)4.45915674
11IMP biosynthetic process (GO:0006188)4.36416348
12protein localization to kinetochore (GO:0034501)4.33538823
13DNA strand elongation (GO:0022616)4.32010631
14mitotic nuclear envelope disassembly (GO:0007077)4.26393912
15DNA replication checkpoint (GO:0000076)4.21421674
16establishment of viral latency (GO:0019043)4.17382680
17telomere maintenance via semi-conservative replication (GO:0032201)4.13840153
18DNA replication-dependent nucleosome assembly (GO:0006335)4.05274719
19DNA replication-dependent nucleosome organization (GO:0034723)4.05274719
20ribosomal large subunit biogenesis (GO:0042273)4.04229077
21metaphase plate congression (GO:0051310)4.01604767
22ribosomal small subunit assembly (GO:0000028)4.01136093
23membrane disassembly (GO:0030397)3.97254062
24nuclear envelope disassembly (GO:0051081)3.97254062
25ribosome biogenesis (GO:0042254)3.97046547
26folic acid-containing compound biosynthetic process (GO:0009396)3.95485005
27kinetochore organization (GO:0051383)3.92741061
28IMP metabolic process (GO:0046040)3.87125069
29* ribosome assembly (GO:0042255)3.84840428
30ribonucleoprotein complex biogenesis (GO:0022613)3.80680945
31telomere maintenance via recombination (GO:0000722)3.80305886
32non-recombinational repair (GO:0000726)3.76586305
33double-strand break repair via nonhomologous end joining (GO:0006303)3.76586305
34DNA ligation (GO:0006266)3.75664736
35* chromatin remodeling at centromere (GO:0031055)3.74978829
36mitotic recombination (GO:0006312)3.73011837
37regulation of spindle organization (GO:0090224)3.69557299
38* CENP-A containing nucleosome assembly (GO:0034080)3.68667613
39protein localization to chromosome, centromeric region (GO:0071459)3.62891559
40telomere maintenance via telomere lengthening (GO:0010833)3.58768910
41translational termination (GO:0006415)3.55636527
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54980280
43* DNA replication-independent nucleosome assembly (GO:0006336)3.52291613
44* DNA replication-independent nucleosome organization (GO:0034724)3.52291613
45viral transcription (GO:0019083)3.52134554
46DNA topological change (GO:0006265)3.51991340
47proteasome assembly (GO:0043248)3.51825135
48establishment of chromosome localization (GO:0051303)3.51797357
49protein complex localization (GO:0031503)3.51645330
50kinetochore assembly (GO:0051382)3.49927410
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47790590
52regulation of mitotic spindle checkpoint (GO:1903504)3.47790590
53translational initiation (GO:0006413)3.47548902
54rRNA processing (GO:0006364)3.45951451
55attachment of spindle microtubules to kinetochore (GO:0008608)3.44692807
56pore complex assembly (GO:0046931)3.44090985
57spliceosomal snRNP assembly (GO:0000387)3.40457459
58mitotic chromosome condensation (GO:0007076)3.38981219
59positive regulation of chromosome segregation (GO:0051984)3.36339969
60rRNA metabolic process (GO:0016072)3.35238394
61establishment of integrated proviral latency (GO:0075713)3.34007633
62DNA duplex unwinding (GO:0032508)3.33777637
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32738307
64DNA geometric change (GO:0032392)3.32547880
65regulation of posttranscriptional gene silencing (GO:0060147)3.31751567
66regulation of gene silencing by miRNA (GO:0060964)3.31751567
67regulation of gene silencing by RNA (GO:0060966)3.31751567
68ribosomal small subunit biogenesis (GO:0042274)3.30514461
69regulation of mitotic spindle organization (GO:0060236)3.30495206
70* histone exchange (GO:0043486)3.29521170
71DNA double-strand break processing (GO:0000729)3.28813811
72regulation of helicase activity (GO:0051095)3.28364236
73spindle checkpoint (GO:0031577)3.27896430
74translational elongation (GO:0006414)3.27773863
75mitotic sister chromatid segregation (GO:0000070)3.27773527
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27294908
77heterochromatin organization (GO:0070828)3.27241477
78negative regulation of chromosome segregation (GO:0051985)3.24731947
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.24260584
80negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23876328
81negative regulation of sister chromatid segregation (GO:0033046)3.23876328
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.23876328
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23876328
84DNA damage response, detection of DNA damage (GO:0042769)3.21449088
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.20089035
86mitotic sister chromatid cohesion (GO:0007064)3.19876125
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.19736627
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19736627
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19717606
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19452186
91regulation of translational fidelity (GO:0006450)3.18993122
92mitotic spindle checkpoint (GO:0071174)3.18281010
93spindle assembly checkpoint (GO:0071173)3.16383819
94mitotic spindle assembly checkpoint (GO:0007094)3.14859715
95maturation of 5.8S rRNA (GO:0000460)3.14727106
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13968939
97L-serine metabolic process (GO:0006563)3.13437557
98protein K6-linked ubiquitination (GO:0085020)3.13244937
99regulation of chromosome segregation (GO:0051983)3.13046595
100tRNA aminoacylation for protein translation (GO:0006418)3.12452454
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11897025
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10793817
103amino acid activation (GO:0043038)3.09311050
104tRNA aminoacylation (GO:0043039)3.09311050
105sister chromatid segregation (GO:0000819)3.08575479
106cellular protein complex localization (GO:0034629)3.08246297
107* ATP-dependent chromatin remodeling (GO:0043044)3.07033496
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06747785
109negative regulation of ligase activity (GO:0051352)3.06747785
110mitotic G2/M transition checkpoint (GO:0044818)3.05465023
111pre-miRNA processing (GO:0031054)3.03274327
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03207142
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02691158
114RNA splicing, via transesterification reactions (GO:0000375)3.02611217
115nuclear envelope organization (GO:0006998)3.02451176
116spliceosomal complex assembly (GO:0000245)3.01908746
117transcription-coupled nucleotide-excision repair (GO:0006283)3.01612030
118pseudouridine synthesis (GO:0001522)3.01062654
119DNA catabolic process, exonucleolytic (GO:0000738)3.00401597
120termination of RNA polymerase II transcription (GO:0006369)2.99926930
121mRNA splicing, via spliceosome (GO:0000398)2.99763592
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99763592
123regulation of mitotic sister chromatid separation (GO:0010965)2.99628011
124regulation of mitotic sister chromatid segregation (GO:0033047)2.99628011
125regulation of sister chromatid segregation (GO:0033045)2.99628011
126rRNA modification (GO:0000154)2.98385748
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96068845
128regulation of histone H3-K9 methylation (GO:0051570)2.93718988
129chaperone-mediated protein complex assembly (GO:0051131)2.93098366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22002001
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.67966931
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10970440
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95201206
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47630012
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37727275
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15768910
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04275939
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04001727
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.98984357
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82770408
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.73292828
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.72441658
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61033339
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58243196
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53360227
17AR_21909140_ChIP-Seq_LNCAP_Human2.48354158
18* XRN2_22483619_ChIP-Seq_HELA_Human2.40460758
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38073649
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35718809
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33685963
22* VDR_23849224_ChIP-Seq_CD4+_Human2.17000965
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14571905
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10640664
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.10339080
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03032896
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00756706
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94108730
29DCP1A_22483619_ChIP-Seq_HELA_Human1.92432043
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92027671
31FOXP3_21729870_ChIP-Seq_TREG_Human1.89638588
32* TTF2_22483619_ChIP-Seq_HELA_Human1.89427956
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84989842
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81310272
35* EGR1_19374776_ChIP-ChIP_THP-1_Human1.78701352
36GABP_19822575_ChIP-Seq_HepG2_Human1.77731135
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77143710
38ELK1_19687146_ChIP-ChIP_HELA_Human1.75091331
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70474568
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69106537
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67002897
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66220363
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62598254
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57950613
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57775085
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55858719
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.54244602
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49703231
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47559318
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47405289
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47293279
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45962340
53CIITA_25753668_ChIP-Seq_RAJI_Human1.41429960
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40473494
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38656995
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38440787
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.37974482
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37705238
59* YY1_21170310_ChIP-Seq_MESCs_Mouse1.33110900
60* MYC_22102868_ChIP-Seq_BL_Human1.33002712
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32545907
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.32017021
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30738448
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30544472
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30018230
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22521068
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21839387
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21839387
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21839387
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21355308
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20767319
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17240276
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.14772009
74EWS_26573619_Chip-Seq_HEK293_Human1.14116820
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13666299
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.11272127
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10740720
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10282896
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08204660
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.07612362
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07497303
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07278743
83* TFEB_21752829_ChIP-Seq_HELA_Human1.06595137
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05188649
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02010770
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01973888
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01164816
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00424062
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99631646
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99321492
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.99198485
92MYC_18940864_ChIP-ChIP_HL60_Human0.99150611
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99009057
94FUS_26573619_Chip-Seq_HEK293_Human0.97419334
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96794791
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96591240
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95132155
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94727459
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93813160
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93244457
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.93017616
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91589420
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90252313
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89756987
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87028650
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86724491
107* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86092137
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.85375580
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84993252
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84544084
111* CHD1_26751641_Chip-Seq_LNCaP_Human0.82146787
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80120226
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79612128
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77955543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67677470
2MP0004957_abnormal_blastocyst_morpholog4.73587816
3* MP0010094_abnormal_chromosome_stability4.61544644
4MP0003111_abnormal_nucleus_morphology4.46907112
5MP0008057_abnormal_DNA_replication4.14450596
6* MP0003077_abnormal_cell_cycle4.02862233
7MP0008058_abnormal_DNA_repair3.54044073
8MP0003123_paternal_imprinting3.13587411
9MP0008007_abnormal_cellular_replicative2.88878036
10MP0008932_abnormal_embryonic_tissue2.83716497
11* MP0001730_embryonic_growth_arrest2.63685111
12MP0010352_gastrointestinal_tract_polyps2.56302603
13* MP0000350_abnormal_cell_proliferation2.38902102
14MP0008877_abnormal_DNA_methylation2.29273712
15MP0002396_abnormal_hematopoietic_system2.12667750
16MP0010307_abnormal_tumor_latency2.04350701
17MP0005380_embryogenesis_phenotype1.99978470
18MP0001672_abnormal_embryogenesis/_devel1.99978470
19* MP0001697_abnormal_embryo_size1.91109994
20MP0003786_premature_aging1.89962265
21MP0003806_abnormal_nucleotide_metabolis1.83227823
22MP0002084_abnormal_developmental_patter1.79731641
23MP0003984_embryonic_growth_retardation1.78275183
24MP0002085_abnormal_embryonic_tissue1.78080739
25MP0002088_abnormal_embryonic_growth/wei1.74259251
26MP0004197_abnormal_fetal_growth/weight/1.72696435
27* MP0002080_prenatal_lethality1.71658416
28MP0003718_maternal_effect1.67946298
29MP0003567_abnormal_fetal_cardiomyocyte1.66668538
30MP0003890_abnormal_embryonic-extraembry1.66435640
31MP0003121_genomic_imprinting1.65299326
32MP0010030_abnormal_orbit_morphology1.64962240
33* MP0002086_abnormal_extraembryonic_tissu1.56413708
34MP0003941_abnormal_skin_development1.37282792
35MP0000537_abnormal_urethra_morphology1.36733607
36MP0004133_heterotaxia1.35911549
37* MP0000313_abnormal_cell_death1.35412535
38MP0006035_abnormal_mitochondrial_morpho1.35377262
39MP0005076_abnormal_cell_differentiation1.35036178
40MP0009053_abnormal_anal_canal1.31985628
41MP0003315_abnormal_perineum_morphology1.31602462
42MP0000490_abnormal_crypts_of1.30315172
43MP0002254_reproductive_system_inflammat1.24451183
44MP0001188_hyperpigmentation1.24348282
45MP0002210_abnormal_sex_determination1.22913389
46MP0003119_abnormal_digestive_system1.22161105
47* MP0001293_anophthalmia1.21878267
48MP0004808_abnormal_hematopoietic_stem1.21860312
49* MP0002019_abnormal_tumor_incidence1.19621056
50MP0009672_abnormal_birth_weight1.16446901
51MP0002796_impaired_skin_barrier1.15054178
52MP0003937_abnormal_limbs/digits/tail_de1.11158012
53MP0001145_abnormal_male_reproductive1.09937621
54MP0006072_abnormal_retinal_apoptosis1.05485469
55MP0002111_abnormal_tail_morphology1.01070570
56MP0000579_abnormal_nail_morphology1.00610621
57MP0002877_abnormal_melanocyte_morpholog1.00606276
58MP0006292_abnormal_olfactory_placode0.98888790
59MP0003705_abnormal_hypodermis_morpholog0.94078498
60MP0004185_abnormal_adipocyte_glucose0.93572882
61MP0000653_abnormal_sex_gland0.93224477
62MP0002160_abnormal_reproductive_system0.92904181
63MP0009703_decreased_birth_body0.92734350
64MP0002233_abnormal_nose_morphology0.89932378
65MP0001929_abnormal_gametogenesis0.88052641
66MP0006036_abnormal_mitochondrial_physio0.84780450
67MP0009333_abnormal_splenocyte_physiolog0.83455372
68MP0005367_renal/urinary_system_phenotyp0.81399913
69MP0000516_abnormal_urinary_system0.81399913
70MP0000703_abnormal_thymus_morphology0.81192188
71MP0005397_hematopoietic_system_phenotyp0.81123021
72MP0001545_abnormal_hematopoietic_system0.81123021
73MP0000428_abnormal_craniofacial_morphol0.80621615
74MP0010234_abnormal_vibrissa_follicle0.80431300
75MP0003186_abnormal_redox_activity0.80378538
76MP0002102_abnormal_ear_morphology0.79516311
77MP0005384_cellular_phenotype0.78997277
78MP0000358_abnormal_cell_content/0.78314942
79MP0002653_abnormal_ependyma_morphology0.76837815
80MP0003221_abnormal_cardiomyocyte_apopto0.76408785
81MP0001177_atelectasis0.75441441
82MP0002938_white_spotting0.75393651
83MP0001849_ear_inflammation0.75302037
84MP0005023_abnormal_wound_healing0.74845238
85MP0001119_abnormal_female_reproductive0.74831616
86* MP0001286_abnormal_eye_development0.74458412
87MP0003136_yellow_coat_color0.74030417
88MP0001529_abnormal_vocalization0.73120716
89MP0005389_reproductive_system_phenotype0.72805216
90MP0005621_abnormal_cell_physiology0.71637932
91MP0003566_abnormal_cell_adhesion0.71450523
92MP0000432_abnormal_head_morphology0.71244383
93MP0001915_intracranial_hemorrhage0.67703417
94MP0002009_preneoplasia0.67663543
95MP0001661_extended_life_span0.67076854
96MP0002697_abnormal_eye_size0.65773311
97MP0000647_abnormal_sebaceous_gland0.65488244
98MP0000762_abnormal_tongue_morphology0.64763749
99MP0003283_abnormal_digestive_organ0.64732325
100MP0001881_abnormal_mammary_gland0.64137776
101MP0009379_abnormal_foot_pigmentation0.63312316
102MP0003936_abnormal_reproductive_system0.62420806
103MP0005395_other_phenotype0.62196257
104MP0001727_abnormal_embryo_implantation0.61424177
105* MP0002092_abnormal_eye_morphology0.61015851
106MP0002722_abnormal_immune_system0.60037395
107MP0006054_spinal_hemorrhage0.59218013
108MP0000858_altered_metastatic_potential0.59197730
109MP0000750_abnormal_muscle_regeneration0.58954623
110MP0002751_abnormal_autonomic_nervous0.58582382
111MP0001299_abnormal_eye_distance/0.57966025
112MP0001346_abnormal_lacrimal_gland0.57910254
113MP0000477_abnormal_intestine_morphology0.57794205
114MP0008770_decreased_survivor_rate0.57474785
115MP0000049_abnormal_middle_ear0.57412832
116MP0005266_abnormal_metabolism0.57106987
117MP0003115_abnormal_respiratory_system0.56988878
118MP0003385_abnormal_body_wall0.56690842
119* MP0003861_abnormal_nervous_system0.55352994
120MP0009697_abnormal_copulation0.55076804
121MP0004264_abnormal_extraembryonic_tissu0.54876343
122MP0003935_abnormal_craniofacial_develop0.54288599
123MP0000733_abnormal_muscle_development0.54066697
124* MP0002398_abnormal_bone_marrow0.53090422
125MP0000689_abnormal_spleen_morphology0.52769941
126MP0003755_abnormal_palate_morphology0.52688335
127MP0005501_abnormal_skin_physiology0.52265294
128MP0002114_abnormal_axial_skeleton0.52069328
129MP0003763_abnormal_thymus_physiology0.51729726

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.52540459
2Colon cancer (HP:0003003)4.17299015
3Breast hypoplasia (HP:0003187)4.07411835
4Reticulocytopenia (HP:0001896)3.96062998
5Chromsome breakage (HP:0040012)3.71108737
6Ependymoma (HP:0002888)3.65492330
7Oral leukoplakia (HP:0002745)3.64255889
8Selective tooth agenesis (HP:0001592)3.60484955
9Medulloblastoma (HP:0002885)3.60375031
10Abnormality of the labia minora (HP:0012880)3.43877074
11Abnormality of cells of the erythroid lineage (HP:0012130)3.42005111
12Patellar aplasia (HP:0006443)3.33395523
13Carpal bone hypoplasia (HP:0001498)3.30588972
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21655267
15Abnormality of the anterior horn cell (HP:0006802)3.17421528
16Degeneration of anterior horn cells (HP:0002398)3.17421528
17Abnormality of chromosome stability (HP:0003220)3.13230236
18Aplasia/Hypoplasia of the patella (HP:0006498)3.12315882
19Embryonal renal neoplasm (HP:0011794)3.10651179
20Agnosia (HP:0010524)3.06713079
21Abnormal number of erythroid precursors (HP:0012131)3.04180167
22Absent radius (HP:0003974)3.03110013
23Rough bone trabeculation (HP:0100670)3.02401311
24Impulsivity (HP:0100710)2.96948194
25Meckel diverticulum (HP:0002245)2.96591571
26Supernumerary spleens (HP:0009799)2.91528454
27Absent thumb (HP:0009777)2.91344159
28Abnormality of the preputium (HP:0100587)2.91093191
29Rhabdomyosarcoma (HP:0002859)2.83050063
30Absent forearm bone (HP:0003953)2.82863486
31Aplasia involving forearm bones (HP:0009822)2.82863486
32Abnormality of methionine metabolism (HP:0010901)2.82107437
33Abnormality of the ileum (HP:0001549)2.76946363
34Microvesicular hepatic steatosis (HP:0001414)2.76839343
35Cerebral hypomyelination (HP:0006808)2.71118358
36Abnormal number of incisors (HP:0011064)2.69005270
37Cortical dysplasia (HP:0002539)2.64869493
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.61878871
39Aplastic anemia (HP:0001915)2.61698839
40Neoplasm of the pancreas (HP:0002894)2.58768317
41Stenosis of the external auditory canal (HP:0000402)2.58297300
42Proximal placement of thumb (HP:0009623)2.58160476
43Ectopic kidney (HP:0000086)2.56664000
44Atresia of the external auditory canal (HP:0000413)2.56636774
45Macrocytic anemia (HP:0001972)2.55698386
46Duodenal stenosis (HP:0100867)2.54561284
47Small intestinal stenosis (HP:0012848)2.54561284
48Increased hepatocellular lipid droplets (HP:0006565)2.54439152
49Premature graying of hair (HP:0002216)2.50388754
50Abnormal lung lobation (HP:0002101)2.49916903
51Myelodysplasia (HP:0002863)2.49760259
52Deviation of the thumb (HP:0009603)2.49165572
53Horseshoe kidney (HP:0000085)2.44129546
54Spastic diplegia (HP:0001264)2.42797307
55Increased serum pyruvate (HP:0003542)2.40962948
56Abnormality of glycolysis (HP:0004366)2.39452743
57Abnormality of the astrocytes (HP:0100707)2.39033538
58Astrocytoma (HP:0009592)2.39033538
59Trismus (HP:0000211)2.36370904
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.35047534
61Biliary tract neoplasm (HP:0100574)2.34654993
62Increased nuchal translucency (HP:0010880)2.33307008
63Abnormality of serum amino acid levels (HP:0003112)2.28510280
64Glioma (HP:0009733)2.25805975
65Neoplasm of the oral cavity (HP:0100649)2.24665130
66Basal cell carcinoma (HP:0002671)2.24622840
67Tracheoesophageal fistula (HP:0002575)2.24121265
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23840902
69Abnormal trabecular bone morphology (HP:0100671)2.23494218
70Pallor (HP:0000980)2.22852624
71Sloping forehead (HP:0000340)2.22472992
72Megaloblastic anemia (HP:0001889)2.22428372
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20775598
74Abnormality of the duodenum (HP:0002246)2.18540554
75Volvulus (HP:0002580)2.17979477
76Bone marrow hypocellularity (HP:0005528)2.17713229
77Cellular immunodeficiency (HP:0005374)2.16834293
78Lipid accumulation in hepatocytes (HP:0006561)2.15796791
79Microretrognathia (HP:0000308)2.15601886
8011 pairs of ribs (HP:0000878)2.14576843
81Progressive external ophthalmoplegia (HP:0000590)2.13742578
82Neoplasm of the colon (HP:0100273)2.09485691
83Aplasia/hypoplasia of the humerus (HP:0006507)2.08178572
84Neoplasm of striated muscle (HP:0009728)2.06602550
85Cleft eyelid (HP:0000625)2.05391244
86Triphalangeal thumb (HP:0001199)2.04657980
87Squamous cell carcinoma (HP:0002860)2.03853080
88Abnormality of abdominal situs (HP:0011620)2.03335123
89Abdominal situs inversus (HP:0003363)2.03335123
90Missing ribs (HP:0000921)2.01938479
91Glossoptosis (HP:0000162)2.00612336
92Short thumb (HP:0009778)2.00006683
93Acute encephalopathy (HP:0006846)1.98203213
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96679079
95Amaurosis fugax (HP:0100576)1.95719930
96Premature ovarian failure (HP:0008209)1.94962607
97Facial cleft (HP:0002006)1.94034938
98Neoplasm of the adrenal gland (HP:0100631)1.93927000
99Acute necrotizing encephalopathy (HP:0006965)1.92869518
100Short middle phalanx of the 5th finger (HP:0004220)1.92631130
101Pancreatic islet-cell hyperplasia (HP:0004510)1.92606244
102Multiple enchondromatosis (HP:0005701)1.92078170
103Postnatal microcephaly (HP:0005484)1.91882640
104Homocystinuria (HP:0002156)1.91014944
105Abnormality of homocysteine metabolism (HP:0010919)1.91014944
106Abnormality of the pons (HP:0007361)1.90215346
107Choanal atresia (HP:0000453)1.89081826
108Breast aplasia (HP:0100783)1.87960978
109Hypoplasia of the radius (HP:0002984)1.87494060
110Cerebral edema (HP:0002181)1.87291510
111Ovarian neoplasm (HP:0100615)1.86751075
112Cafe-au-lait spot (HP:0000957)1.85660101
113Hypoplasia of the pons (HP:0012110)1.84242907
114Reduced antithrombin III activity (HP:0001976)1.83657332
115Abnormality of the umbilical cord (HP:0010881)1.83445705
116Progressive muscle weakness (HP:0003323)1.83132324
117Prominent nose (HP:0000448)1.81888646
118Abnormality of the carotid arteries (HP:0005344)1.80087380
119Abnormality of the septum pellucidum (HP:0007375)1.79632499
120Secondary amenorrhea (HP:0000869)1.79512161
121Uterine neoplasm (HP:0010784)1.79368125
122Slender long bone (HP:0003100)1.79260323
123Duplicated collecting system (HP:0000081)1.79243057
124Breast carcinoma (HP:0003002)1.78867359
125Facial hemangioma (HP:0000329)1.78257525
126Nephroblastoma (Wilms tumor) (HP:0002667)1.77965605
127Neoplasm of the small intestine (HP:0100833)1.77891851
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77457595
129Abnormality of alanine metabolism (HP:0010916)1.77457595
130Hyperalaninemia (HP:0003348)1.77457595
131Embryonal neoplasm (HP:0002898)1.76814978
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.76501507
133Neoplasm of the adrenal cortex (HP:0100641)1.75790505
134Abnormality of pyrimidine metabolism (HP:0004353)1.75301497
135Hyperglycinemia (HP:0002154)1.74599885
136Aplasia/Hypoplasia of the breasts (HP:0010311)1.74324782
137Abnormality of the fetal cardiovascular system (HP:0010948)1.74080190
138Abnormal umbilical cord blood vessels (HP:0011403)1.74080190
139Single umbilical artery (HP:0001195)1.74080190
140Spinal muscular atrophy (HP:0007269)1.73983980
141Asplenia (HP:0001746)1.73813890
142Abnormal biliary tract morphology (HP:0012440)1.73003754
143Increased CSF lactate (HP:0002490)1.72905639
144Increased serum lactate (HP:0002151)1.72257925
145Bifid tongue (HP:0010297)1.70289809
146Gonadotropin excess (HP:0000837)1.69934248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.61105644
2CDC74.48755892
3BUB14.13401658
4TSSK63.38823167
5EIF2AK13.37174692
6SRPK12.90238988
7NEK12.79939815
8NEK22.72712086
9VRK22.66473390
10TTK2.59436085
11MKNK12.41067622
12PLK42.34678611
13TAF12.17040285
14BRSK22.09653234
15EIF2AK32.04302010
16* PLK12.03256043
17PASK2.00780255
18CDK122.00197906
19ACVR1B1.95168847
20NME21.94393562
21PNCK1.87719822
22MKNK21.87315920
23AURKB1.79082650
24* PLK31.71576784
25CDK71.69771902
26RPS6KB21.64590331
27VRK11.64022700
28* ATR1.63337387
29TNIK1.57639769
30TRIM281.56556557
31RPS6KA41.48866981
32STK161.48568146
33CHEK21.46158261
34EPHA21.41632835
35CHEK11.40565874
36MAP3K81.38524949
37TGFBR11.35249740
38DYRK31.31583514
39NUAK11.31581938
40TESK21.30893382
41CDK41.27599202
42AURKA1.21208423
43BRD41.20186827
44BRSK11.18850221
45STK101.16909538
46TLK11.14153257
47PBK1.13226099
48PAK41.08067018
49SCYL21.06664184
50ATM1.05495727
51SMG11.04968996
52EEF2K1.01487631
53STK40.97813527
54* CDK20.95887938
55CSNK2A20.87872093
56ZAK0.85510725
57ERBB40.79070524
58MELK0.76818278
59CSNK2A10.74208038
60* CDK10.73996297
61PIM10.73485990
62EIF2AK20.71872171
63CCNB10.71531305
64WNK30.71351913
65LATS20.68818349
66STK38L0.68779985
67STK30.65989945
68STK240.62707145
69FLT30.61143742
70BMPR1B0.59839665
71CDK80.57312244
72PAK10.56993751
73BRAF0.56775317
74LATS10.55600405
75* CSNK1E0.55281670
76BCR0.54667556
77PRKCI0.54197936
78LRRK20.53386832
79CLK10.51797794
80CSNK1G10.51050871
81FGFR10.49288448
82PDK40.49273267
83PDK30.49273267
84MTOR0.48961068
85MAP3K100.48282411
86* ALK0.48275161
87CDK30.47615216
88PRKDC0.47158952
89MST40.46296749
90PLK20.44767208
91PKN20.43600656
92RPS6KA50.42123910
93TESK10.40551331
94DAPK10.39633850
95PIM20.37455774
96AKT20.37278685
97CSNK1D0.36727656
98CDK190.35651340
99PAK20.35513013
100AKT30.34145779
101CDK90.33780207
102MAPK140.30728724
103NME10.30307569
104PDK20.29912103
105MAP2K30.26111904
106KDR0.25979250
107MAP3K120.25737516
108TAOK20.23143237
109MARK30.22316574
110CDK180.21579528
111RPS6KB10.21462703
112NEK90.21127748
113MAPK10.19664036
114* GSK3B0.19275500
115AKT10.19248714
116NLK0.19246706
117MAPKAPK50.18466794
118YES10.18348296
119OXSR10.17917436
120CSNK1G30.17734962
121CDK11A0.17732106
122MST1R0.17495253
123MET0.16791443
124DYRK20.14854600
125ERBB30.14423350
126RPS6KA10.13705334

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.84389201
2Mismatch repair_Homo sapiens_hsa034304.36016700
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21629152
4RNA transport_Homo sapiens_hsa030133.58324565
5Spliceosome_Homo sapiens_hsa030403.53905867
6RNA polymerase_Homo sapiens_hsa030203.40284024
7Ribosome_Homo sapiens_hsa030103.38658048
8Proteasome_Homo sapiens_hsa030503.31464250
9Homologous recombination_Homo sapiens_hsa034402.95293585
10One carbon pool by folate_Homo sapiens_hsa006702.94669433
11Nucleotide excision repair_Homo sapiens_hsa034202.89913605
12Cell cycle_Homo sapiens_hsa041102.84223270
13Base excision repair_Homo sapiens_hsa034102.78090721
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77252399
15Pyrimidine metabolism_Homo sapiens_hsa002402.44391811
16Non-homologous end-joining_Homo sapiens_hsa034502.33069040
17Fanconi anemia pathway_Homo sapiens_hsa034602.17623292
18RNA degradation_Homo sapiens_hsa030182.05736065
19Basal transcription factors_Homo sapiens_hsa030222.05068377
20mRNA surveillance pathway_Homo sapiens_hsa030151.95966210
21p53 signaling pathway_Homo sapiens_hsa041151.55027332
22Pyruvate metabolism_Homo sapiens_hsa006201.53274315
23Purine metabolism_Homo sapiens_hsa002301.34351293
24Propanoate metabolism_Homo sapiens_hsa006401.32400015
25Epstein-Barr virus infection_Homo sapiens_hsa051691.26662980
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12181461
27Oocyte meiosis_Homo sapiens_hsa041141.08967486
28Systemic lupus erythematosus_Homo sapiens_hsa053221.07775977
29Parkinsons disease_Homo sapiens_hsa050121.05327008
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.00221709
31Steroid biosynthesis_Homo sapiens_hsa001000.99313950
32Antigen processing and presentation_Homo sapiens_hsa046120.96239510
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95937601
34Oxidative phosphorylation_Homo sapiens_hsa001900.95320672
35Viral carcinogenesis_Homo sapiens_hsa052030.93495349
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89769168
37Biosynthesis of amino acids_Homo sapiens_hsa012300.88823604
38Vitamin B6 metabolism_Homo sapiens_hsa007500.86281003
39Selenocompound metabolism_Homo sapiens_hsa004500.84750820
40Herpes simplex infection_Homo sapiens_hsa051680.82838663
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.82255716
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80605531
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80605162
44HTLV-I infection_Homo sapiens_hsa051660.73629075
45Fatty acid elongation_Homo sapiens_hsa000620.71787134
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.71659297
47Thyroid cancer_Homo sapiens_hsa052160.69527567
48MicroRNAs in cancer_Homo sapiens_hsa052060.68035839
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66180781
50Folate biosynthesis_Homo sapiens_hsa007900.62302184
51TGF-beta signaling pathway_Homo sapiens_hsa043500.62000569
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58343145
53Hippo signaling pathway_Homo sapiens_hsa043900.57718858
54Legionellosis_Homo sapiens_hsa051340.56077100
55Basal cell carcinoma_Homo sapiens_hsa052170.55910640
56Pentose phosphate pathway_Homo sapiens_hsa000300.55128303
57Small cell lung cancer_Homo sapiens_hsa052220.54831299
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53085013
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51031352
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49938651
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49093604
62Protein export_Homo sapiens_hsa030600.46505894
63Alzheimers disease_Homo sapiens_hsa050100.46210021
64Glutathione metabolism_Homo sapiens_hsa004800.45506052
65Carbon metabolism_Homo sapiens_hsa012000.45250493
66Lysine degradation_Homo sapiens_hsa003100.44767288
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38058461
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37043139
69Arginine and proline metabolism_Homo sapiens_hsa003300.35806805
70Colorectal cancer_Homo sapiens_hsa052100.35402596
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34397968
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33895827
73Huntingtons disease_Homo sapiens_hsa050160.33736535
74Alcoholism_Homo sapiens_hsa050340.33453573
75Hedgehog signaling pathway_Homo sapiens_hsa043400.32990408
76Adherens junction_Homo sapiens_hsa045200.31953243
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31569329
78Sulfur relay system_Homo sapiens_hsa041220.28111013
79HIF-1 signaling pathway_Homo sapiens_hsa040660.27975247
80Pathways in cancer_Homo sapiens_hsa052000.27353885
81Vitamin digestion and absorption_Homo sapiens_hsa049770.26522130
82Apoptosis_Homo sapiens_hsa042100.25881189
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.25654546
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25423042
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23520166
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23256137
87Notch signaling pathway_Homo sapiens_hsa043300.22973197
88Fatty acid metabolism_Homo sapiens_hsa012120.22548022
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22521709
90Bladder cancer_Homo sapiens_hsa052190.22414445
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21267429
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20928402
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20471770
94Hepatitis B_Homo sapiens_hsa051610.19781075
95Prostate cancer_Homo sapiens_hsa052150.19569370
96mTOR signaling pathway_Homo sapiens_hsa041500.18723886
97Fructose and mannose metabolism_Homo sapiens_hsa000510.18389614
98Arginine biosynthesis_Homo sapiens_hsa002200.17247679
99Tight junction_Homo sapiens_hsa045300.16811265
100Wnt signaling pathway_Homo sapiens_hsa043100.16622200
101Chronic myeloid leukemia_Homo sapiens_hsa052200.16318663
102Measles_Homo sapiens_hsa051620.15035082
103Viral myocarditis_Homo sapiens_hsa054160.14016021
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13648561
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.13445739
106Sulfur metabolism_Homo sapiens_hsa009200.13349888
107Galactose metabolism_Homo sapiens_hsa000520.13148377
108N-Glycan biosynthesis_Homo sapiens_hsa005100.12483560
109Metabolic pathways_Homo sapiens_hsa011000.12445924
110beta-Alanine metabolism_Homo sapiens_hsa004100.12401210
111Fatty acid degradation_Homo sapiens_hsa000710.11609305
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11545192
113Influenza A_Homo sapiens_hsa051640.10517840
114Melanoma_Homo sapiens_hsa052180.10424048
115Renin-angiotensin system_Homo sapiens_hsa046140.09737655
116Peroxisome_Homo sapiens_hsa041460.09514161
117Shigellosis_Homo sapiens_hsa051310.09061370
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08821874
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08782342
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08522847
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07589732
122Proteoglycans in cancer_Homo sapiens_hsa052050.05397672
123Type I diabetes mellitus_Homo sapiens_hsa049400.05002512
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.00454652
125Butanoate metabolism_Homo sapiens_hsa00650-0.0080698

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »