NPM1P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.65097956
2water-soluble vitamin biosynthetic process (GO:0042364)5.80310228
3rRNA modification (GO:0000154)5.48430072
4cullin deneddylation (GO:0010388)5.30429319
5rRNA methylation (GO:0031167)5.24774897
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.02261500
7regulation of immunoglobulin secretion (GO:0051023)4.97839439
8ribosome assembly (GO:0042255)4.91899809
9protein deneddylation (GO:0000338)4.74795586
10regulation of isotype switching to IgG isotypes (GO:0048302)4.69532460
11regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.57239607
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.45163552
13DNA deamination (GO:0045006)4.38880258
14DNA damage response, detection of DNA damage (GO:0042769)4.19612877
15regulation of cellular amino acid metabolic process (GO:0006521)4.16201922
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10765577
17DNA catabolic process, exonucleolytic (GO:0000738)4.05700420
18transcription from mitochondrial promoter (GO:0006390)3.93759077
19DNA double-strand break processing (GO:0000729)3.93711054
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85270673
21pseudouridine synthesis (GO:0001522)3.83614319
22maturation of 5.8S rRNA (GO:0000460)3.81806312
23regulation of regulatory T cell differentiation (GO:0045589)3.80532169
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.78465470
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.78465470
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.78465470
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.76307331
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.76307331
29termination of RNA polymerase I transcription (GO:0006363)3.74606194
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71400413
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66789108
32negative regulation of ligase activity (GO:0051352)3.65800818
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65800818
34chaperone-mediated protein transport (GO:0072321)3.60703929
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.57710081
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57710081
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57251362
38signal transduction involved in cell cycle checkpoint (GO:0072395)3.51981458
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51334466
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51334466
41mitochondrial RNA metabolic process (GO:0000959)3.50319839
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48675297
43formation of translation preinitiation complex (GO:0001731)3.40927964
44peptidyl-histidine modification (GO:0018202)3.40560568
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40538058
46ribosome biogenesis (GO:0042254)3.40374191
47protein targeting to mitochondrion (GO:0006626)3.37203156
48positive regulation of DNA recombination (GO:0045911)3.36228413
49positive regulation of isotype switching (GO:0045830)3.35540880
50mitochondrial respiratory chain complex assembly (GO:0033108)3.34041215
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.30549528
52transcription initiation from RNA polymerase I promoter (GO:0006361)3.27074557
53negative regulation of B cell apoptotic process (GO:0002903)3.24784732
54tRNA processing (GO:0008033)3.23464859
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23321501
56positive regulation of interleukin-17 production (GO:0032740)3.23149106
57respiratory chain complex IV assembly (GO:0008535)3.23015225
58protein localization to mitochondrion (GO:0070585)3.20440652
59IMP biosynthetic process (GO:0006188)3.20245481
60ATP synthesis coupled proton transport (GO:0015986)3.18745511
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18745511
62folic acid-containing compound biosynthetic process (GO:0009396)3.15467186
63positive regulation of ligase activity (GO:0051351)3.14354150
64rRNA processing (GO:0006364)3.12496721
65establishment of protein localization to mitochondrion (GO:0072655)3.11439755
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.11221036
67termination of RNA polymerase III transcription (GO:0006386)3.11221036
68transcription from RNA polymerase I promoter (GO:0006360)3.10971658
69tRNA metabolic process (GO:0006399)3.08665329
70protein complex biogenesis (GO:0070271)3.08081032
71rRNA metabolic process (GO:0016072)3.06143810
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05989188
73tRNA aminoacylation (GO:0043039)3.00489226
74amino acid activation (GO:0043038)3.00489226
75regulation of chronic inflammatory response (GO:0002676)3.00020961
76tRNA aminoacylation for protein translation (GO:0006418)2.99994674
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99782300
78tRNA methylation (GO:0030488)2.95505925
79mitochondrial respiratory chain complex I assembly (GO:0032981)2.94687278
80NADH dehydrogenase complex assembly (GO:0010257)2.94687278
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94687278
82protein neddylation (GO:0045116)2.92242752
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90805739
84IMP metabolic process (GO:0046040)2.90614339
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.90308607
86negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.89720310
87positive regulation of cell cycle arrest (GO:0071158)2.88694077
88regulation of cellular amine metabolic process (GO:0033238)2.87151892
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84445345
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.82992347
91ncRNA metabolic process (GO:0034660)2.82858673
92synapsis (GO:0007129)2.82757209
93negative regulation of protein ubiquitination (GO:0031397)2.79448216
94ncRNA processing (GO:0034470)2.78303323
95regulation of ligase activity (GO:0051340)2.77250448
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.76975018
97tRNA modification (GO:0006400)2.69435180
98nucleobase biosynthetic process (GO:0046112)2.67890955
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66466824
100protein K6-linked ubiquitination (GO:0085020)2.64734202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.44886689
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.77761814
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.70448326
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.04001669
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04075814
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99806657
7VDR_23849224_ChIP-Seq_CD4+_Human2.84811491
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75577287
9ELK1_19687146_ChIP-ChIP_HELA_Human2.66139913
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61509756
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.60412546
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.59571547
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.56006045
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48807503
15ZNF274_21170338_ChIP-Seq_K562_Hela2.44399560
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37353184
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29036174
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23698321
19FOXP3_21729870_ChIP-Seq_TREG_Human2.12420263
20VDR_22108803_ChIP-Seq_LS180_Human2.08139174
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06112279
22EWS_26573619_Chip-Seq_HEK293_Human2.05541240
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02153174
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.91682636
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84991275
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83744151
27DCP1A_22483619_ChIP-Seq_HELA_Human1.82216050
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.80313148
29E2F7_22180533_ChIP-Seq_HELA_Human1.79462647
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72385670
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69985618
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59088273
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55717088
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54156388
35TAF15_26573619_Chip-Seq_HEK293_Human1.50552204
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50229665
37MYC_18940864_ChIP-ChIP_HL60_Human1.48995713
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44295003
39TTF2_22483619_ChIP-Seq_HELA_Human1.42538882
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41534827
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41011702
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.41008563
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40768904
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38753304
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38666717
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37079318
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.37072852
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36935744
49FUS_26573619_Chip-Seq_HEK293_Human1.34548591
50P300_19829295_ChIP-Seq_ESCs_Human1.30862476
51TP53_22573176_ChIP-Seq_HFKS_Human1.29524820
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.28003265
53GABP_19822575_ChIP-Seq_HepG2_Human1.27333275
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27190426
55NANOG_19829295_ChIP-Seq_ESCs_Human1.27190426
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25195591
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19913026
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18736891
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18611252
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16929431
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14791961
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12588282
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10646163
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09381008
65IGF1R_20145208_ChIP-Seq_DFB_Human1.08461850
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07540130
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.06202206
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.05106690
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04840969
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04773343
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.04416674
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04416674
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04029848
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03816951
75ER_23166858_ChIP-Seq_MCF-7_Human1.03264881
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01753167
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00662258
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00418251
79SALL4_22934838_ChIP-ChIP_CD34+_Human0.97171592
80IRF8_21731497_ChIP-ChIP_J774_Mouse0.96295674
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96089388
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94993330
83P300_18555785_Chip-Seq_ESCs_Mouse0.94734788
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.93813664
85XRN2_22483619_ChIP-Seq_HELA_Human0.93439206
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92671732
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91583602
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90957885
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90586058
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90462559
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89715313
92SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89681405
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88201148
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87514238
95P53_22387025_ChIP-Seq_ESCs_Mouse0.87219714
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.86352950
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86343706
98NCOR_22424771_ChIP-Seq_293T_Human0.86313798
99ELF5_23300383_ChIP-Seq_T47D_Human0.86140120
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85933600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.14548765
2MP0003718_maternal_effect3.11123297
3MP0008058_abnormal_DNA_repair3.10129945
4MP0003195_calcinosis2.91294117
5MP0010386_abnormal_urinary_bladder2.87044762
6MP0002138_abnormal_hepatobiliary_system2.86176804
7MP0002102_abnormal_ear_morphology2.68887767
8MP0004957_abnormal_blastocyst_morpholog2.63254583
9MP0003786_premature_aging2.48726820
10MP0003950_abnormal_plasma_membrane2.46459054
11MP0001835_abnormal_antigen_presentation2.29797599
12MP0003806_abnormal_nucleotide_metabolis2.26389373
13MP0008877_abnormal_DNA_methylation2.16047336
14MP0003300_gastrointestinal_ulcer2.15134183
15MP0003693_abnormal_embryo_hatching2.12582641
16MP0000465_gastrointestinal_hemorrhage2.11906506
17MP0006036_abnormal_mitochondrial_physio2.11555833
18MP0001853_heart_inflammation2.06455639
19MP0008872_abnormal_physiological_respon1.95235764
20MP0005084_abnormal_gallbladder_morpholo1.94588538
21MP0010094_abnormal_chromosome_stability1.91445590
22MP0006035_abnormal_mitochondrial_morpho1.88224951
23MP0008875_abnormal_xenobiotic_pharmacok1.85102970
24MP0001968_abnormal_touch/_nociception1.84992106
25MP0002163_abnormal_gland_morphology1.77977957
26MP0002277_abnormal_respiratory_mucosa1.76247197
27MP0008057_abnormal_DNA_replication1.72105776
28MP0005379_endocrine/exocrine_gland_phen1.69792723
29MP0004782_abnormal_surfactant_physiolog1.68914824
30MP0009697_abnormal_copulation1.68903156
31MP0001873_stomach_inflammation1.66963109
32MP0009333_abnormal_splenocyte_physiolog1.65311192
33MP0004145_abnormal_muscle_electrophysio1.63880141
34MP0002736_abnormal_nociception_after1.63050371
35MP0001984_abnormal_olfaction1.61371349
36MP0006292_abnormal_olfactory_placode1.55942460
37MP0005310_abnormal_salivary_gland1.55026762
38MP0003567_abnormal_fetal_cardiomyocyte1.45394486
39MP0004885_abnormal_endolymph1.43909278
40MP0005085_abnormal_gallbladder_physiolo1.39703842
41MP0001293_anophthalmia1.36866380
42MP0002006_tumorigenesis1.34362011
43MP0005645_abnormal_hypothalamus_physiol1.33533861
44MP0003186_abnormal_redox_activity1.25174895
45MP0001485_abnormal_pinna_reflex1.21333083
46MP0005671_abnormal_response_to1.20379701
47MP0002148_abnormal_hypersensitivity_rea1.19941142
48MP0002166_altered_tumor_susceptibility1.18275338
49MP0006072_abnormal_retinal_apoptosis1.17415873
50MP0005387_immune_system_phenotype1.16043670
51MP0001790_abnormal_immune_system1.16043670
52MP0002837_dystrophic_cardiac_calcinosis1.13047615
53MP0008789_abnormal_olfactory_epithelium1.08946735
54MP0000383_abnormal_hair_follicle1.08524623
55MP0003111_abnormal_nucleus_morphology1.06621673
56MP0001501_abnormal_sleep_pattern1.05993429
57MP0003011_delayed_dark_adaptation1.04120084
58MP0001529_abnormal_vocalization1.03160844
59MP0005551_abnormal_eye_electrophysiolog1.01872916
60MP0005395_other_phenotype1.00283960
61MP0002396_abnormal_hematopoietic_system0.98542529
62MP0004215_abnormal_myocardial_fiber0.98136712
63MP0005389_reproductive_system_phenotype0.96954278
64MP0002160_abnormal_reproductive_system0.95667282
65MP0001661_extended_life_span0.95451384
66MP0003119_abnormal_digestive_system0.94841599
67MP0002693_abnormal_pancreas_physiology0.92013168
68MP0000538_abnormal_urinary_bladder0.91715834
69MP0001764_abnormal_homeostasis0.89775738
70MP0003763_abnormal_thymus_physiology0.89437050
71MP0003077_abnormal_cell_cycle0.89059772
72MP0003646_muscle_fatigue0.89008465
73MP0001881_abnormal_mammary_gland0.85893296
74MP0001800_abnormal_humoral_immune0.84673054
75MP0000647_abnormal_sebaceous_gland0.84416428
76MP0002876_abnormal_thyroid_physiology0.84144324
77MP0005646_abnormal_pituitary_gland0.83284583
78MP0003283_abnormal_digestive_organ0.82346419
79MP0000685_abnormal_immune_system0.80321867
80MP0003866_abnormal_defecation0.80042963
81MP0005410_abnormal_fertilization0.79874795
82MP0002210_abnormal_sex_determination0.78732529
83MP0001929_abnormal_gametogenesis0.78225265
84MP0008873_increased_physiological_sensi0.77166133
85MP0001919_abnormal_reproductive_system0.74834989
86MP0002272_abnormal_nervous_system0.74459407
87MP0003936_abnormal_reproductive_system0.71749607
88MP0008932_abnormal_embryonic_tissue0.70320715
89MP0003137_abnormal_impulse_conducting0.69051151
90MP0001119_abnormal_female_reproductive0.68186521
91MP0002405_respiratory_system_inflammati0.67778381
92MP0008007_abnormal_cellular_replicative0.66187127
93MP0000372_irregular_coat_pigmentation0.65096880
94MP0004142_abnormal_muscle_tone0.63810904
95MP0005332_abnormal_amino_acid0.62957598
96MP0009764_decreased_sensitivity_to0.62734853
97MP0001348_abnormal_lacrimal_gland0.61862902
98MP0000689_abnormal_spleen_morphology0.61664952
99MP0000653_abnormal_sex_gland0.60780777
100MP0002398_abnormal_bone_marrow0.60345620

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.06969871
2Abnormality of the pons (HP:0007361)3.97492139
3Lipid accumulation in hepatocytes (HP:0006561)3.75245709
4Large for gestational age (HP:0001520)3.53629899
53-Methylglutaconic aciduria (HP:0003535)3.34247949
6Increased CSF lactate (HP:0002490)3.30086672
7Congenital, generalized hypertrichosis (HP:0004540)3.29163475
8Mitochondrial inheritance (HP:0001427)3.24336547
9Acute necrotizing encephalopathy (HP:0006965)3.22069687
10Volvulus (HP:0002580)3.05047760
11Acute encephalopathy (HP:0006846)3.04805401
12Increased serum lactate (HP:0002151)3.01713026
13Duplicated collecting system (HP:0000081)3.01112867
14Methylmalonic acidemia (HP:0002912)3.00850599
15Urethral obstruction (HP:0000796)2.98132984
16Pancytopenia (HP:0001876)2.94598926
17Hypoplasia of the pons (HP:0012110)2.87213289
18Renal Fanconi syndrome (HP:0001994)2.85601320
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85378479
20Hyperglycinemia (HP:0002154)2.84923290
21Stomatitis (HP:0010280)2.83700130
22Abnormality of the renal collecting system (HP:0004742)2.74223199
23Abnormal mitochondria in muscle tissue (HP:0008316)2.71753310
24Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71388123
25Progressive macrocephaly (HP:0004481)2.70858960
26Abnormality of serum amino acid levels (HP:0003112)2.70558544
27Hepatic necrosis (HP:0002605)2.68654410
28Exertional dyspnea (HP:0002875)2.65340977
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63396836
30Hepatocellular necrosis (HP:0001404)2.53462965
31IgG deficiency (HP:0004315)2.51014292
32Type I transferrin isoform profile (HP:0003642)2.50996881
33Increased intramyocellular lipid droplets (HP:0012240)2.50647548
34Abnormality of methionine metabolism (HP:0010901)2.43101253
35Oral leukoplakia (HP:0002745)2.42608384
36Pancreatic cysts (HP:0001737)2.41776679
37Submucous cleft hard palate (HP:0000176)2.41102416
38Hypothermia (HP:0002045)2.40906539
39Cerebral edema (HP:0002181)2.38655606
40Methylmalonic aciduria (HP:0012120)2.38086294
41Megaloblastic anemia (HP:0001889)2.37544681
42Abnormality of the ileum (HP:0001549)2.36294396
43Testicular atrophy (HP:0000029)2.34555174
44Abnormal lung lobation (HP:0002101)2.32838562
45Lactic acidosis (HP:0003128)2.24424536
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24054247
47Hypoglycemic coma (HP:0001325)2.23555829
48Respiratory difficulties (HP:0002880)2.21222400
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.20438601
50Increased serum pyruvate (HP:0003542)2.20113708
51Degeneration of anterior horn cells (HP:0002398)2.15368903
52Abnormality of the anterior horn cell (HP:0006802)2.15368903
53Pancreatic islet-cell hyperplasia (HP:0004510)2.14095823
54Lethargy (HP:0001254)2.12143183
55Meckel diverticulum (HP:0002245)2.11811873
56Colon cancer (HP:0003003)2.11766921
57Abnormality of the labia minora (HP:0012880)2.11421907
58Ureteral duplication (HP:0000073)2.11311972
59Abnormality of the preputium (HP:0100587)2.09302451
60Reduced antithrombin III activity (HP:0001976)2.05412534
61Nephronophthisis (HP:0000090)2.05097170
62Cerebral hemorrhage (HP:0001342)2.04577009
63Conjunctival hamartoma (HP:0100780)2.03879278
64Increased muscle lipid content (HP:0009058)2.03710436
65Abnormality of glycine metabolism (HP:0010895)2.02879142
66Abnormality of serine family amino acid metabolism (HP:0010894)2.02879142
67Abnormality of vitamin B metabolism (HP:0004340)2.02833086
68Abnormality of midbrain morphology (HP:0002418)2.02805016
69Molar tooth sign on MRI (HP:0002419)2.02805016
70Aplasia/hypoplasia of the uterus (HP:0008684)2.02557223
71Exercise intolerance (HP:0003546)2.01449154
72Optic disc pallor (HP:0000543)2.01401612
73Abnormality of urine glucose concentration (HP:0011016)1.99716741
74Glycosuria (HP:0003076)1.99716741
75Generalized aminoaciduria (HP:0002909)1.97970825
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.97102050
77Supernumerary spleens (HP:0009799)1.96188071
78Limb hypertonia (HP:0002509)1.96071260
79Pendular nystagmus (HP:0012043)1.95401712
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94959920
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94959920
82Abnormality of alanine metabolism (HP:0010916)1.94014304
83Hyperalaninemia (HP:0003348)1.94014304
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94014304
85Type 2 muscle fiber atrophy (HP:0003554)1.92933826
86Horseshoe kidney (HP:0000085)1.92792665
87Hypomagnesemia (HP:0002917)1.91818428
88Abnormality of glycolysis (HP:0004366)1.89103640
89Hypoproteinemia (HP:0003075)1.87378538
90Respiratory failure (HP:0002878)1.81252309
91Clubbing of toes (HP:0100760)1.79871671
92Aplastic anemia (HP:0001915)1.74392628
93Sparse eyelashes (HP:0000653)1.73972267
94Fatigue (HP:0012378)1.73835525
95Breast carcinoma (HP:0003002)1.73594108
96Constricted visual fields (HP:0001133)1.72887752
97Myelodysplasia (HP:0002863)1.72481181
98Spinal muscular atrophy (HP:0007269)1.72263330
99Neoplasm of the adrenal gland (HP:0100631)1.71960884
100Abnormality of renal resorption (HP:0011038)1.70661192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.78325063
2EIF2AK34.41023399
3EIF2AK14.11305760
4MST43.81128216
5BUB13.53856201
6VRK23.15152178
7TAF12.91331576
8PBK2.77501222
9ADRBK22.69728134
10NEK12.50953815
11MKNK22.33908106
12SRPK12.29459507
13NUAK12.28948481
14PLK32.01639524
15ZAK1.99285230
16VRK11.86701458
17MKNK11.81624009
18TLK11.75730875
19STK391.67367556
20PASK1.53284659
21EIF2AK21.50388526
22MAP3K121.41336500
23FRK1.37618345
24STK161.34611062
25ALK1.33815276
26NME11.33546202
27GRK11.32483853
28TXK1.27319003
29OXSR11.18112909
30BMPR1B1.16758738
31TEC1.11398825
32TRIM281.10027052
33TAOK31.08168511
34WNK40.95659464
35CDC70.94942285
36INSRR0.94481003
37BCR0.94139179
38ACVR1B0.90984315
39PLK20.86643799
40STK240.84473531
41TGFBR10.83129153
42PAK40.81629421
43CDK80.76190108
44PLK40.75310001
45CLK10.74909406
46ITK0.73764679
47STK40.69404353
48PLK10.69366587
49DYRK20.68542396
50PINK10.67215284
51PDK20.66910925
52MAP3K140.66312765
53WNK30.65769937
54GRK50.65137753
55TIE10.62292198
56FGFR10.61525986
57CCNB10.59216479
58MAP4K20.57278429
59TNIK0.57261474
60PRKCE0.55429949
61STK30.54528764
62IKBKB0.53071259
63PRKCG0.51702606
64CSNK1G20.49876579
65MYLK0.48436124
66ADRBK10.48290544
67STK38L0.47970586
68MAP2K60.45377476
69CSNK1A1L0.44734350
70RPS6KA50.40614996
71ATR0.40322311
72AURKB0.40314955
73DAPK10.40150155
74CSNK1E0.39862409
75PIK3CG0.39838331
76CSNK1G10.39310788
77PRKCQ0.38708826
78BCKDK0.38433276
79CSNK2A20.37949434
80PHKG20.37590253
81PHKG10.37590253
82AKT30.36766153
83KIT0.36715422
84CSNK1G30.35602065
85MAPKAPK50.35235456
86ATM0.34815163
87CSNK2A10.33675898
88IRAK10.33383533
89TTK0.30909376
90ILK0.29804156
91WEE10.29558812
92NLK0.29435515
93JAK30.26927660
94SIK30.25243969
95CAMK2A0.22866529
96IKBKE0.20022181
97ERBB30.19955252
98CHEK10.17704426
99LCK0.16438884
100PRKCA0.16122344

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.21268908
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97239596
3Protein export_Homo sapiens_hsa030603.44110538
4Basal transcription factors_Homo sapiens_hsa030223.06843226
5RNA polymerase_Homo sapiens_hsa030202.55434425
6One carbon pool by folate_Homo sapiens_hsa006702.53702869
7Asthma_Homo sapiens_hsa053102.29815674
8Oxidative phosphorylation_Homo sapiens_hsa001902.29114668
9Propanoate metabolism_Homo sapiens_hsa006402.25954610
10RNA transport_Homo sapiens_hsa030132.15672683
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14983201
12Parkinsons disease_Homo sapiens_hsa050122.03273218
13Allograft rejection_Homo sapiens_hsa053301.93463549
14RNA degradation_Homo sapiens_hsa030181.89176949
15Autoimmune thyroid disease_Homo sapiens_hsa053201.83733339
16Mismatch repair_Homo sapiens_hsa034301.71929148
17Spliceosome_Homo sapiens_hsa030401.71313764
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.69580456
19Non-homologous end-joining_Homo sapiens_hsa034501.68799823
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67167578
21Homologous recombination_Homo sapiens_hsa034401.62020991
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60599143
23Ribosome_Homo sapiens_hsa030101.60560333
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47049848
25Type I diabetes mellitus_Homo sapiens_hsa049401.46216043
26Nucleotide excision repair_Homo sapiens_hsa034201.45753258
27DNA replication_Homo sapiens_hsa030301.36754515
28Pyrimidine metabolism_Homo sapiens_hsa002401.35404260
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31296770
30Huntingtons disease_Homo sapiens_hsa050161.25122058
31Phototransduction_Homo sapiens_hsa047441.16925515
32Fanconi anemia pathway_Homo sapiens_hsa034601.15838592
33Vitamin B6 metabolism_Homo sapiens_hsa007501.13931422
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12083082
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11947263
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.10028343
37Purine metabolism_Homo sapiens_hsa002301.09787409
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09470984
39Alzheimers disease_Homo sapiens_hsa050101.07725280
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05369109
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.03880975
42Nitrogen metabolism_Homo sapiens_hsa009101.03384391
43Graft-versus-host disease_Homo sapiens_hsa053321.01856290
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97187148
45Linoleic acid metabolism_Homo sapiens_hsa005910.93761114
46Collecting duct acid secretion_Homo sapiens_hsa049660.93585051
47Primary immunodeficiency_Homo sapiens_hsa053400.91650064
48Pyruvate metabolism_Homo sapiens_hsa006200.83698523
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83453516
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81861270
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81453979
52Tryptophan metabolism_Homo sapiens_hsa003800.80825810
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78275063
54Base excision repair_Homo sapiens_hsa034100.76488839
55Sulfur metabolism_Homo sapiens_hsa009200.75345518
56Steroid biosynthesis_Homo sapiens_hsa001000.73932331
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72377769
58Peroxisome_Homo sapiens_hsa041460.71267467
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69601921
60beta-Alanine metabolism_Homo sapiens_hsa004100.67615030
61Glutathione metabolism_Homo sapiens_hsa004800.66239167
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66198475
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65394173
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63812137
65Butanoate metabolism_Homo sapiens_hsa006500.62101625
66p53 signaling pathway_Homo sapiens_hsa041150.61651023
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61565819
68Hematopoietic cell lineage_Homo sapiens_hsa046400.61471101
69Rheumatoid arthritis_Homo sapiens_hsa053230.59979958
70Measles_Homo sapiens_hsa051620.59945858
71Fatty acid elongation_Homo sapiens_hsa000620.59714171
72Ether lipid metabolism_Homo sapiens_hsa005650.59663162
73Caffeine metabolism_Homo sapiens_hsa002320.58988088
74Fat digestion and absorption_Homo sapiens_hsa049750.56606127
75Metabolic pathways_Homo sapiens_hsa011000.56498637
76Epstein-Barr virus infection_Homo sapiens_hsa051690.56051074
77Regulation of autophagy_Homo sapiens_hsa041400.54816556
78Antigen processing and presentation_Homo sapiens_hsa046120.52599020
79Nicotine addiction_Homo sapiens_hsa050330.50329555
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.49773951
81Fatty acid degradation_Homo sapiens_hsa000710.49236653
82Selenocompound metabolism_Homo sapiens_hsa004500.45405842
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43204639
84Mineral absorption_Homo sapiens_hsa049780.42717498
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.42666034
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.42174130
87Vitamin digestion and absorption_Homo sapiens_hsa049770.42058163
88Glycerolipid metabolism_Homo sapiens_hsa005610.40305785
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40231055
90mRNA surveillance pathway_Homo sapiens_hsa030150.39680833
91Cardiac muscle contraction_Homo sapiens_hsa042600.38039767
92Chemical carcinogenesis_Homo sapiens_hsa052040.37613314
93Retinol metabolism_Homo sapiens_hsa008300.37277894
94Legionellosis_Homo sapiens_hsa051340.36847685
95Carbon metabolism_Homo sapiens_hsa012000.36803976
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.36768300
97Olfactory transduction_Homo sapiens_hsa047400.35528364
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33924907
99Cell cycle_Homo sapiens_hsa041100.32076749
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31150805

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