NPM1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.19333972
2exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.83500556
3nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.68501669
4DNA double-strand break processing (GO:0000729)4.66252447
5urate metabolic process (GO:0046415)4.62909687
6rRNA modification (GO:0000154)4.34294458
7DNA deamination (GO:0045006)4.30568780
8ribosomal large subunit biogenesis (GO:0042273)4.16683001
9segment specification (GO:0007379)4.07909766
10ncRNA catabolic process (GO:0034661)4.03431541
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.01038522
12positive regulation of protein homodimerization activity (GO:0090073)3.99062405
13proteasome assembly (GO:0043248)3.85910272
14chaperone-mediated protein transport (GO:0072321)3.76462232
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74047617
16somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.70883594
17isotype switching (GO:0045190)3.70883594
18somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.70883594
19rRNA methylation (GO:0031167)3.66823520
20ribosomal small subunit assembly (GO:0000028)3.59479891
21ATP synthesis coupled proton transport (GO:0015986)3.56345037
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56345037
23intracellular protein transmembrane import (GO:0044743)3.53611293
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49500955
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48164779
26positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48119642
27spliceosomal snRNP assembly (GO:0000387)3.46867371
28labyrinthine layer development (GO:0060711)3.43692411
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.42457202
30regulation of sarcomere organization (GO:0060297)3.40911951
31regulation of immunoglobulin secretion (GO:0051023)3.39070137
32positive regulation of ligase activity (GO:0051351)3.38854228
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.36074691
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31727499
35negative regulation of ligase activity (GO:0051352)3.27917397
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27917397
37ubiquinone biosynthetic process (GO:0006744)3.26601506
38rRNA processing (GO:0006364)3.24799529
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19190419
40regulation of T cell chemotaxis (GO:0010819)3.18461599
41positive regulation of T cell chemotaxis (GO:0010820)3.18461599
42purine nucleotide salvage (GO:0032261)3.18029975
43rRNA metabolic process (GO:0016072)3.16492674
44chromatin remodeling at centromere (GO:0031055)3.16370926
45positive regulation of translational initiation (GO:0045948)3.15449863
46ubiquinone metabolic process (GO:0006743)3.14749782
47maturation of 5.8S rRNA (GO:0000460)3.14014418
48DNA integration (GO:0015074)3.12992553
49response to nitric oxide (GO:0071731)3.09460782
50mitochondrial respiratory chain complex assembly (GO:0033108)3.08766835
51CENP-A containing nucleosome assembly (GO:0034080)3.08384138
52protein complex biogenesis (GO:0070271)3.07711733
53regulation of cellular amino acid metabolic process (GO:0006521)3.05371199
54IMP biosynthetic process (GO:0006188)3.04267721
55termination of RNA polymerase I transcription (GO:0006363)3.03487036
56water-soluble vitamin biosynthetic process (GO:0042364)3.02180260
577-methylguanosine mRNA capping (GO:0006370)2.96865264
58AMP metabolic process (GO:0046033)2.96581931
59DNA catabolic process, exonucleolytic (GO:0000738)2.95716883
60pseudouridine synthesis (GO:0001522)2.94939097
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.94929498
62NADH dehydrogenase complex assembly (GO:0010257)2.94929498
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94929498
64purine nucleobase metabolic process (GO:0006144)2.93768862
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90545710
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90388167
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90388167
687-methylguanosine RNA capping (GO:0009452)2.90293809
69RNA capping (GO:0036260)2.90293809
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.89102263
71regulation of ubiquitin-protein transferase activity (GO:0051438)2.88941969
72transcription elongation from RNA polymerase I promoter (GO:0006362)2.88523522
73regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.88493950
74somatic recombination of immunoglobulin gene segments (GO:0016447)2.87270989
75purine nucleobase biosynthetic process (GO:0009113)2.87073228
76cellular component biogenesis (GO:0044085)2.86631756
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86475062
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86475062
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86475062
80regulation of ligase activity (GO:0051340)2.83827349
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83798686
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83798686
83ribosome biogenesis (GO:0042254)2.82163481
84resolution of meiotic recombination intermediates (GO:0000712)2.80603808
85nucleobase biosynthetic process (GO:0046112)2.80051036
86positive regulation of interleukin-17 production (GO:0032740)2.79628172
87nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.74424646
88ribonucleoprotein complex biogenesis (GO:0022613)2.72562065
89IMP metabolic process (GO:0046040)2.70973699
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.70665258
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70665258
92signal transduction involved in cell cycle checkpoint (GO:0072395)2.68334721
93quinone biosynthetic process (GO:1901663)2.67590109
94respiratory chain complex IV assembly (GO:0008535)2.67400762
95membrane repolarization during action potential (GO:0086011)2.67290052
96somatic diversification of immunoglobulins (GO:0016445)2.66582978
97acrosome assembly (GO:0001675)2.65516757
98histone exchange (GO:0043486)2.63244427
99intracellular protein transmembrane transport (GO:0065002)2.62197087
100indolalkylamine catabolic process (GO:0046218)2.60933328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.61435190
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.19734210
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.80421846
4ZNF274_21170338_ChIP-Seq_K562_Hela3.14429380
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12044115
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00970337
7ELK1_19687146_ChIP-ChIP_HELA_Human2.80780213
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53444560
9E2F7_22180533_ChIP-Seq_HELA_Human2.50730833
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50377064
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.49727385
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44769598
13FOXP3_21729870_ChIP-Seq_TREG_Human2.43063901
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38492279
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.32617185
16VDR_22108803_ChIP-Seq_LS180_Human2.29615459
17VDR_23849224_ChIP-Seq_CD4+_Human2.28015848
18EWS_26573619_Chip-Seq_HEK293_Human2.27525174
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26169794
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24535589
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.22966840
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21832209
23FUS_26573619_Chip-Seq_HEK293_Human2.20461703
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19126550
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16319885
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14822623
27MYC_18940864_ChIP-ChIP_HL60_Human2.02971932
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.93909431
29IGF1R_20145208_ChIP-Seq_DFB_Human1.89497496
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79218876
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71715069
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70910823
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65573401
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.62967966
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.62967966
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62505713
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55378868
38P300_19829295_ChIP-Seq_ESCs_Human1.53957545
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51339390
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48918978
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48877790
42TAF15_26573619_Chip-Seq_HEK293_Human1.48216221
43TTF2_22483619_ChIP-Seq_HELA_Human1.47609431
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46632445
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45210890
46IRF1_19129219_ChIP-ChIP_H3396_Human1.41317009
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36512451
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36201306
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35052961
50DCP1A_22483619_ChIP-Seq_HELA_Human1.33274751
51GBX2_23144817_ChIP-Seq_PC3_Human1.32586119
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32237548
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28838059
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26423254
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25419502
56NANOG_19829295_ChIP-Seq_ESCs_Human1.24370243
57SOX2_19829295_ChIP-Seq_ESCs_Human1.24370243
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23833000
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23784575
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23227811
61ER_23166858_ChIP-Seq_MCF-7_Human1.21328253
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19825975
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19621352
64TP53_22573176_ChIP-Seq_HFKS_Human1.19040447
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.18439149
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16822205
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12824692
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11287210
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10852554
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10187887
71XRN2_22483619_ChIP-Seq_HELA_Human1.09858017
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.07086513
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07036554
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05355227
75TCF4_22108803_ChIP-Seq_LS180_Human1.04875974
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04837665
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02400096
78BCAT_22108803_ChIP-Seq_LS180_Human1.01421828
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00608732
80AR_20517297_ChIP-Seq_VCAP_Human1.00293346
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99993535
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99090258
83GABP_19822575_ChIP-Seq_HepG2_Human0.98641936
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97830324
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97040801
86ERG_20517297_ChIP-Seq_VCAP_Human0.95856191
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94459152
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93061225
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92332484
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.92284520
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90994966
92NCOR_22424771_ChIP-Seq_293T_Human0.86758061
93RUNX2_22187159_ChIP-Seq_PCA_Human0.85091090
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.84600237
95CDX2_22108803_ChIP-Seq_LS180_Human0.84477022
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84139615
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83574890
98NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82667213
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.82364131
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.81910706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology3.74430218
2MP0005377_hearing/vestibular/ear_phenot3.74430218
3MP0008007_abnormal_cellular_replicative3.40013230
4MP0002102_abnormal_ear_morphology2.90200190
5MP0006292_abnormal_olfactory_placode2.52210124
6MP0002837_dystrophic_cardiac_calcinosis2.51924861
7MP0003718_maternal_effect2.49133738
8MP0003806_abnormal_nucleotide_metabolis2.44418652
9MP0003786_premature_aging2.35995151
10MP0008995_early_reproductive_senescence2.28259460
11MP0003136_yellow_coat_color2.23053228
12MP0010094_abnormal_chromosome_stability2.07458608
13MP0001485_abnormal_pinna_reflex2.06725123
14MP0005084_abnormal_gallbladder_morpholo2.04209534
15MP0006035_abnormal_mitochondrial_morpho2.02833180
16MP0003693_abnormal_embryo_hatching2.00661001
17MP0005670_abnormal_white_adipose1.94531192
18MP0002653_abnormal_ependyma_morphology1.88564665
19MP0002009_preneoplasia1.78936003
20MP0002160_abnormal_reproductive_system1.77583585
21MP0009333_abnormal_splenocyte_physiolog1.74534799
22MP0003195_calcinosis1.70802140
23MP0002006_tumorigenesis1.67123143
24MP0008789_abnormal_olfactory_epithelium1.66992688
25MP0002166_altered_tumor_susceptibility1.66432291
26MP0001835_abnormal_antigen_presentation1.65767904
27MP0005174_abnormal_tail_pigmentation1.65036994
28MP0004215_abnormal_myocardial_fiber1.62994879
29MP0008058_abnormal_DNA_repair1.62592033
30MP0003077_abnormal_cell_cycle1.52861661
31MP0000566_synostosis1.52193760
32MP0001764_abnormal_homeostasis1.51425640
33MP0000490_abnormal_crypts_of1.47775411
34MP0003937_abnormal_limbs/digits/tail_de1.46061028
35MP0000569_abnormal_digit_pigmentation1.45700712
36MP0008872_abnormal_physiological_respon1.43412866
37MP0003567_abnormal_fetal_cardiomyocyte1.40429574
38MP0003646_muscle_fatigue1.40195198
39MP0005083_abnormal_biliary_tract1.39685576
40MP0001293_anophthalmia1.38473032
41MP0000015_abnormal_ear_pigmentation1.38108738
42MP0008877_abnormal_DNA_methylation1.36271552
43MP0006072_abnormal_retinal_apoptosis1.35049372
44MP0002277_abnormal_respiratory_mucosa1.33566475
45MP0004957_abnormal_blastocyst_morpholog1.32297614
46MP0005075_abnormal_melanosome_morpholog1.29053449
47MP0006036_abnormal_mitochondrial_physio1.28449586
48MP0003172_abnormal_lysosome_physiology1.24935616
49MP0000383_abnormal_hair_follicle1.24930326
50MP0005389_reproductive_system_phenotype1.24436696
51MP0005085_abnormal_gallbladder_physiolo1.24038653
52MP0004084_abnormal_cardiac_muscle1.23009806
53MP0002095_abnormal_skin_pigmentation1.21654484
54MP0008057_abnormal_DNA_replication1.19705711
55MP0004145_abnormal_muscle_electrophysio1.14637090
56MP0002938_white_spotting1.14096672
57MP0005379_endocrine/exocrine_gland_phen1.11241635
58MP0003011_delayed_dark_adaptation1.09637152
59MP0005636_abnormal_mineral_homeostasis1.03978450
60MP0003315_abnormal_perineum_morphology1.03167471
61MP0000049_abnormal_middle_ear1.02629050
62MP0005394_taste/olfaction_phenotype1.02548414
63MP0005499_abnormal_olfactory_system1.02548414
64MP0004147_increased_porphyrin_level1.02093744
65MP0005408_hypopigmentation1.01123796
66MP0002249_abnormal_larynx_morphology0.97760066
67MP0002229_neurodegeneration0.97604782
68MP0003763_abnormal_thymus_physiology0.96273383
69MP0001348_abnormal_lacrimal_gland0.95663352
70MP0009250_abnormal_appendicular_skeleto0.95302426
71MP0009379_abnormal_foot_pigmentation0.95029594
72MP0005646_abnormal_pituitary_gland0.94729065
73MP0003123_paternal_imprinting0.94519821
74MP0005551_abnormal_eye_electrophysiolog0.94462274
75MP0001873_stomach_inflammation0.92960219
76MP0001919_abnormal_reproductive_system0.92498778
77MP0009384_cardiac_valve_regurgitation0.88187943
78MP0001529_abnormal_vocalization0.84595508
79MP0004484_altered_response_of0.83832892
80MP0008875_abnormal_xenobiotic_pharmacok0.79537753
81MP0000631_abnormal_neuroendocrine_gland0.78886927
82MP0000685_abnormal_immune_system0.77964728
83MP0001929_abnormal_gametogenesis0.77033864
84MP0002210_abnormal_sex_determination0.76604901
85MP0005253_abnormal_eye_physiology0.75721623
86MP0009046_muscle_twitch0.74627794
87MP0002177_abnormal_outer_ear0.72437375
88MP0001486_abnormal_startle_reflex0.69906936
89MP0001145_abnormal_male_reproductive0.69739410
90MP0002272_abnormal_nervous_system0.68954310
91MP0004885_abnormal_endolymph0.68686321
92MP0001963_abnormal_hearing_physiology0.68296868
93MP0002282_abnormal_trachea_morphology0.67077643
94MP0003137_abnormal_impulse_conducting0.66887014
95MP0003186_abnormal_redox_activity0.66621728
96MP0005266_abnormal_metabolism0.64693302
97MP0001661_extended_life_span0.63050859
98MP0004036_abnormal_muscle_relaxation0.63000292
99MP0008932_abnormal_embryonic_tissue0.62919338
100MP0003119_abnormal_digestive_system0.61017432

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)3.95406018
2Type I transferrin isoform profile (HP:0003642)3.82732624
3True hermaphroditism (HP:0010459)3.55979444
4Increased hepatocellular lipid droplets (HP:0006565)3.52396884
5Pancreatic cysts (HP:0001737)3.33308906
6Acute necrotizing encephalopathy (HP:0006965)3.32800392
7Lipid accumulation in hepatocytes (HP:0006561)3.28131064
8Stomatitis (HP:0010280)3.07235487
9Renal Fanconi syndrome (HP:0001994)3.06126843
10Respiratory difficulties (HP:0002880)3.04680792
11Supernumerary spleens (HP:0009799)3.03126634
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.98982412
13Absent/shortened dynein arms (HP:0200106)2.98982412
14Chronic sinusitis (HP:0011109)2.94857000
15Abnormality of midbrain morphology (HP:0002418)2.94581662
16Molar tooth sign on MRI (HP:0002419)2.94581662
17Abnormal protein glycosylation (HP:0012346)2.94285755
18Abnormal glycosylation (HP:0012345)2.94285755
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.94285755
20Abnormal protein N-linked glycosylation (HP:0012347)2.94285755
21Pancreatic fibrosis (HP:0100732)2.93828908
22Mitochondrial inheritance (HP:0001427)2.92259667
23Increased CSF lactate (HP:0002490)2.91647527
24Acute encephalopathy (HP:0006846)2.90688031
25Nephronophthisis (HP:0000090)2.90657240
26Abnormality of placental membranes (HP:0011409)2.88800929
27Amniotic constriction ring (HP:0009775)2.88800929
28Increased intramyocellular lipid droplets (HP:0012240)2.79909231
29Progressive macrocephaly (HP:0004481)2.68450722
30Abnormality of the intrinsic pathway (HP:0010989)2.68105638
31Colon cancer (HP:0003003)2.67260033
32Abnormal mitochondria in muscle tissue (HP:0008316)2.59759854
33Abnormality of urine glucose concentration (HP:0011016)2.54395002
34Glycosuria (HP:0003076)2.54395002
35Congenital stationary night blindness (HP:0007642)2.53706133
36Abnormal ciliary motility (HP:0012262)2.50852255
37Hyperglycinuria (HP:0003108)2.42179731
38Abnormality of the labia minora (HP:0012880)2.39602927
39Cerebral edema (HP:0002181)2.36422434
40Abnormal respiratory epithelium morphology (HP:0012253)2.35135316
41Abnormal respiratory motile cilium morphology (HP:0005938)2.35135316
42Renal cortical cysts (HP:0000803)2.35082265
43Increased muscle lipid content (HP:0009058)2.27523591
44Exertional dyspnea (HP:0002875)2.26707322
45Abnormality of renal resorption (HP:0011038)2.23768632
46Pendular nystagmus (HP:0012043)2.20628349
47Abnormality of the renal medulla (HP:0100957)2.15892100
48Hypoplasia of the fovea (HP:0007750)2.12853478
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.12853478
50Abnormality of methionine metabolism (HP:0010901)2.11679769
51Increased serum lactate (HP:0002151)2.10748825
52Lethargy (HP:0001254)2.10409997
53Cerebral palsy (HP:0100021)2.09491969
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08634065
55Methylmalonic acidemia (HP:0002912)2.07824859
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07114702
57Severe visual impairment (HP:0001141)2.05899629
58Abnormality of the preputium (HP:0100587)2.04602913
59Confusion (HP:0001289)2.03905069
60Optic disc pallor (HP:0000543)2.03438075
61Meckel diverticulum (HP:0002245)2.02024604
62Brushfield spots (HP:0001088)2.02019739
63Cerebellar dysplasia (HP:0007033)2.01712015
64Male pseudohermaphroditism (HP:0000037)2.00121027
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.97622926
66Cystic liver disease (HP:0006706)1.97550356
67Hypoglycemic seizures (HP:0002173)1.97120941
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96582090
69Bile duct proliferation (HP:0001408)1.94375512
70Abnormal biliary tract physiology (HP:0012439)1.94375512
71Adrenal hypoplasia (HP:0000835)1.93025198
72Abnormality of alanine metabolism (HP:0010916)1.92721853
73Hyperalaninemia (HP:0003348)1.92721853
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92721853
75Hyperglycinemia (HP:0002154)1.92380195
76Abnormality of the ileum (HP:0001549)1.89260959
77Medial flaring of the eyebrow (HP:0010747)1.89013956
78Asplenia (HP:0001746)1.88263420
79Hyperphosphaturia (HP:0003109)1.87663905
80Abnormal pupillary function (HP:0007686)1.87440361
81Abnormal rod and cone electroretinograms (HP:0008323)1.87196954
82Lactic acidosis (HP:0003128)1.87099684
83Methylmalonic aciduria (HP:0012120)1.87036954
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87016097
85Abnormality of glycine metabolism (HP:0010895)1.85961429
86Abnormality of serine family amino acid metabolism (HP:0010894)1.85961429
87Abnormality of the anterior horn cell (HP:0006802)1.84591903
88Degeneration of anterior horn cells (HP:0002398)1.84591903
89Prolonged partial thromboplastin time (HP:0003645)1.84332702
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.83417671
91Ventricular fibrillation (HP:0001663)1.83204003
92Abnormality of the fovea (HP:0000493)1.81847799
93Stenosis of the external auditory canal (HP:0000402)1.81611564
94Sclerocornea (HP:0000647)1.81211758
95Central scotoma (HP:0000603)1.81007936
96Trismus (HP:0000211)1.80314981
97Esophageal atresia (HP:0002032)1.78468235
98Hepatocellular necrosis (HP:0001404)1.78198064
99Severe combined immunodeficiency (HP:0004430)1.78185749
100Congenital, generalized hypertrichosis (HP:0004540)1.78142405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48421125
2PBK4.46151608
3VRK12.91830867
4BUB12.75162572
5TAOK32.65563897
6BCKDK2.56651363
7GRK12.33887257
8MST42.31878808
9TSSK62.30142353
10MAP4K22.15097168
11EIF2AK31.96824755
12PLK31.94575353
13NUAK11.93462389
14NME11.80017941
15WEE11.69038605
16SRPK11.67284319
17PASK1.63896255
18ZAK1.63776868
19WNK31.61068454
20ADRBK21.57725369
21MKNK11.55635225
22STK161.55451811
23MAPK71.52997079
24BRSK21.50858202
25ACVR1B1.46471732
26MKNK21.43500062
27CDK31.41969428
28FRK1.36132268
29PLK21.32050711
30PLK41.27159351
31TRIM281.25231681
32TNK21.23336247
33PNCK1.22577695
34STK41.22508434
35PRKD31.21909943
36PINK11.18876111
37TAF11.18440934
38TESK11.13855035
39PDK21.10354977
40WNK41.05145263
41BMPR1B1.00276089
42EIF2AK10.99107576
43CAMKK20.97686349
44STK390.95162367
45CDC70.94762169
46NEK10.92650292
47INSRR0.83839725
48PRKCE0.82701284
49PIK3CG0.82682755
50RPS6KA40.81882488
51SCYL20.78283645
52MAPK130.77869171
53ATR0.77437021
54CSNK1G20.74075740
55CSNK1G30.72969489
56TXK0.72505123
57DYRK30.72379759
58TGFBR10.72325685
59CSNK1G10.71496088
60PLK10.68625797
61NEK90.66823874
62TIE10.58987708
63PAK30.57140803
64EIF2AK20.57067319
65AURKB0.56914896
66IKBKB0.56571547
67BMPR20.55038244
68SYK0.54609803
69OXSR10.52981766
70IGF1R0.52827829
71TNIK0.51712517
72ATM0.50934249
73MAP3K40.50873347
74PRKCG0.50252500
75JAK30.49271644
76STK38L0.47566075
77MAPK120.46391414
78MAP2K60.45141019
79CSNK2A10.44654662
80MAP3K50.44450647
81MAP2K70.44193616
82BRSK10.43103110
83CSNK1A1L0.42032391
84STK30.41704895
85TTK0.41535115
86MAP3K60.40967761
87CSNK1A10.38477594
88KIT0.38020130
89OBSCN0.37876360
90MAPK150.37581204
91CCNB10.37524793
92PRKDC0.37447422
93CASK0.36288155
94PIM10.35196491
95CHEK20.33995205
96CSNK2A20.33276624
97RPS6KB10.33007513
98CSNK1E0.31789054
99ADRBK10.29531632
100PRKCQ0.29356281

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15586542
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.57951164
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92200864
4RNA polymerase_Homo sapiens_hsa030202.82990534
5Ribosome_Homo sapiens_hsa030102.80346865
6Protein export_Homo sapiens_hsa030602.64004532
7RNA degradation_Homo sapiens_hsa030182.51211697
8Oxidative phosphorylation_Homo sapiens_hsa001902.29192875
9Fanconi anemia pathway_Homo sapiens_hsa034602.26366825
10Selenocompound metabolism_Homo sapiens_hsa004502.11534609
11Parkinsons disease_Homo sapiens_hsa050122.07815017
12Mismatch repair_Homo sapiens_hsa034301.99458930
13Non-homologous end-joining_Homo sapiens_hsa034501.81812111
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77067212
15Pyrimidine metabolism_Homo sapiens_hsa002401.74745744
16DNA replication_Homo sapiens_hsa030301.74093781
17RNA transport_Homo sapiens_hsa030131.72930105
18Basal transcription factors_Homo sapiens_hsa030221.66223905
19Retinol metabolism_Homo sapiens_hsa008301.64355579
20One carbon pool by folate_Homo sapiens_hsa006701.60346022
21Peroxisome_Homo sapiens_hsa041461.57247779
22Spliceosome_Homo sapiens_hsa030401.54177113
23Asthma_Homo sapiens_hsa053101.52753313
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52481570
25Homologous recombination_Homo sapiens_hsa034401.51503723
26Huntingtons disease_Homo sapiens_hsa050161.48686083
27Butanoate metabolism_Homo sapiens_hsa006501.44082003
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.42001424
29Fatty acid elongation_Homo sapiens_hsa000621.41902239
30Purine metabolism_Homo sapiens_hsa002301.39899613
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36422961
32Alzheimers disease_Homo sapiens_hsa050101.36138430
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31681649
34Tryptophan metabolism_Homo sapiens_hsa003801.30605399
35Primary immunodeficiency_Homo sapiens_hsa053401.27434610
36Propanoate metabolism_Homo sapiens_hsa006401.27225256
37Allograft rejection_Homo sapiens_hsa053301.27225168
38Nucleotide excision repair_Homo sapiens_hsa034201.25985442
39Autoimmune thyroid disease_Homo sapiens_hsa053201.10218068
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08365129
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05951295
42Type I diabetes mellitus_Homo sapiens_hsa049401.05071894
43Linoleic acid metabolism_Homo sapiens_hsa005910.99216528
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98527687
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98027884
46N-Glycan biosynthesis_Homo sapiens_hsa005100.96468423
47Base excision repair_Homo sapiens_hsa034100.95566926
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.95163408
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94770736
50Sulfur metabolism_Homo sapiens_hsa009200.93041018
51Vitamin B6 metabolism_Homo sapiens_hsa007500.92846030
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91725091
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87483263
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85979264
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85553024
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.84516303
57Phototransduction_Homo sapiens_hsa047440.83373035
58Steroid biosynthesis_Homo sapiens_hsa001000.83359588
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82329943
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81517670
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.79970847
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78786554
63Metabolic pathways_Homo sapiens_hsa011000.77766720
64Cardiac muscle contraction_Homo sapiens_hsa042600.76932912
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73777966
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72597962
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71102184
68mRNA surveillance pathway_Homo sapiens_hsa030150.69738239
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65930808
70Caffeine metabolism_Homo sapiens_hsa002320.64589551
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64483630
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64122402
73Nitrogen metabolism_Homo sapiens_hsa009100.63892452
74Chemical carcinogenesis_Homo sapiens_hsa052040.62307383
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61986711
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.60679661
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60102408
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56191423
79Arginine and proline metabolism_Homo sapiens_hsa003300.56169838
80Glutathione metabolism_Homo sapiens_hsa004800.54485163
81beta-Alanine metabolism_Homo sapiens_hsa004100.53176827
82Ether lipid metabolism_Homo sapiens_hsa005650.53008015
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43041447
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42850037
85Graft-versus-host disease_Homo sapiens_hsa053320.42315463
86Arachidonic acid metabolism_Homo sapiens_hsa005900.41240519
87Fat digestion and absorption_Homo sapiens_hsa049750.40202951
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39381386
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39174172
90Mineral absorption_Homo sapiens_hsa049780.38878911
91Cell cycle_Homo sapiens_hsa041100.37364959
92Fatty acid degradation_Homo sapiens_hsa000710.36698447
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.35359697
94p53 signaling pathway_Homo sapiens_hsa041150.35355391
95Glycerolipid metabolism_Homo sapiens_hsa005610.32246730
96Biosynthesis of amino acids_Homo sapiens_hsa012300.32086462
97Basal cell carcinoma_Homo sapiens_hsa052170.31377257
98Pyruvate metabolism_Homo sapiens_hsa006200.28605266
99Rheumatoid arthritis_Homo sapiens_hsa053230.27705200
100Fatty acid metabolism_Homo sapiens_hsa012120.27174508

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »