NPM1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.87888896
2proteasome assembly (GO:0043248)5.74219240
3exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.76700242
4nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.65315116
5water-soluble vitamin biosynthetic process (GO:0042364)4.62346740
6rRNA modification (GO:0000154)4.60646439
7DNA double-strand break processing (GO:0000729)4.13574503
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08189366
9ribosome assembly (GO:0042255)4.04678346
10GTP biosynthetic process (GO:0006183)4.02036281
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.96669798
12rRNA methylation (GO:0031167)3.96397288
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92381490
14ATP synthesis coupled proton transport (GO:0015986)3.92381490
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.92365971
16positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.89956661
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88863525
18DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87968140
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86484595
20regulation of cellular amino acid metabolic process (GO:0006521)3.84856240
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81596580
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81596580
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81596580
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78516321
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78516321
26ribosomal small subunit assembly (GO:0000028)3.78505541
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78425071
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78425071
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76709350
30chaperone-mediated protein transport (GO:0072321)3.70622382
31DNA catabolic process, exonucleolytic (GO:0000738)3.64367406
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63008841
33negative regulation of ligase activity (GO:0051352)3.63008841
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.61950988
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61950988
36regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.61014478
37protein complex biogenesis (GO:0070271)3.60621288
38pseudouridine synthesis (GO:0001522)3.59530862
39mitochondrial respiratory chain complex assembly (GO:0033108)3.57466499
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.57173153
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.56230359
42termination of RNA polymerase III transcription (GO:0006386)3.56230359
43UTP biosynthetic process (GO:0006228)3.54223659
44respiratory chain complex IV assembly (GO:0008535)3.45316470
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44780433
46termination of RNA polymerase I transcription (GO:0006363)3.42086078
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41729844
48somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.38917890
49isotype switching (GO:0045190)3.38917890
50somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.38917890
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.36312625
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33918501
53rRNA processing (GO:0006364)3.30299443
54protein neddylation (GO:0045116)3.27074215
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26457237
56rRNA metabolic process (GO:0016072)3.24195564
57positive regulation of ligase activity (GO:0051351)3.24185148
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.23658864
59NADH dehydrogenase complex assembly (GO:0010257)3.23658864
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23658864
61regulation of isotype switching to IgG isotypes (GO:0048302)3.18676116
62UTP metabolic process (GO:0046051)3.16430831
63ribosomal large subunit biogenesis (GO:0042273)3.16343800
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11727920
65maturation of 5.8S rRNA (GO:0000460)3.10370123
66kynurenine metabolic process (GO:0070189)3.09613854
67cytochrome complex assembly (GO:0017004)3.07240457
68CTP biosynthetic process (GO:0006241)3.06985619
69CTP metabolic process (GO:0046036)3.06985619
70mitochondrial RNA metabolic process (GO:0000959)3.04918222
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.04535362
72spliceosomal snRNP assembly (GO:0000387)3.01666033
73ribosome biogenesis (GO:0042254)3.00791098
74positive regulation of cell cycle arrest (GO:0071158)2.96139847
75organelle disassembly (GO:1903008)2.95474167
76cytidine metabolic process (GO:0046087)2.95009194
77cytidine catabolic process (GO:0006216)2.95009194
78cytidine deamination (GO:0009972)2.95009194
79transcription from mitochondrial promoter (GO:0006390)2.93498568
80positive regulation of DNA recombination (GO:0045911)2.92975769
81translation (GO:0006412)2.91975475
82cullin deneddylation (GO:0010388)2.91159588
83amino acid salvage (GO:0043102)2.90987982
84L-methionine salvage (GO:0071267)2.90987982
85L-methionine biosynthetic process (GO:0071265)2.90987982
86tRNA processing (GO:0008033)2.90205610
87regulation of chronic inflammatory response (GO:0002676)2.90018473
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87779354
89chromatin remodeling at centromere (GO:0031055)2.86946654
90respiratory electron transport chain (GO:0022904)2.84516486
91regulation of immunoglobulin secretion (GO:0051023)2.84459705
92electron transport chain (GO:0022900)2.84442171
93cellular component biogenesis (GO:0044085)2.84419354
94regulation of ubiquitin-protein transferase activity (GO:0051438)2.82537048
95transcription initiation from RNA polymerase I promoter (GO:0006361)2.82480882
96IMP biosynthetic process (GO:0006188)2.81609689
97maturation of SSU-rRNA (GO:0030490)2.80964974
98positive regulation of interleukin-17 production (GO:0032740)2.80683771
99transcription from RNA polymerase I promoter (GO:0006360)2.79191640
100CENP-A containing nucleosome assembly (GO:0034080)2.78081065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.19108763
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.07144851
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.72325472
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.13845641
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16023280
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07241070
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98533734
8VDR_23849224_ChIP-Seq_CD4+_Human2.88503352
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83156313
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.82590331
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65606962
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62957795
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61919871
14ELK1_19687146_ChIP-ChIP_HELA_Human2.56762068
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54817893
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45905106
17FOXP3_21729870_ChIP-Seq_TREG_Human2.42126917
18VDR_22108803_ChIP-Seq_LS180_Human2.41861965
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.23115028
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22403816
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.09945816
22ZNF274_21170338_ChIP-Seq_K562_Hela2.01997166
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.01406562
24EWS_26573619_Chip-Seq_HEK293_Human1.96124801
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94868198
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86333758
27E2F7_22180533_ChIP-Seq_HELA_Human1.85457927
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81654703
29MYC_18940864_ChIP-ChIP_HL60_Human1.80456987
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79214678
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77905641
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77596885
33TTF2_22483619_ChIP-Seq_HELA_Human1.63438478
34DCP1A_22483619_ChIP-Seq_HELA_Human1.62135584
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58744833
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54214731
37GABP_19822575_ChIP-Seq_HepG2_Human1.51445962
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50865965
39FUS_26573619_Chip-Seq_HEK293_Human1.48990764
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43004597
41TP53_22573176_ChIP-Seq_HFKS_Human1.42072992
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41003317
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38698346
44IGF1R_20145208_ChIP-Seq_DFB_Human1.34139015
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33341516
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33288286
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32870548
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29665690
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.27146308
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27146308
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24592294
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23412307
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22212087
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21619661
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20233376
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19335486
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.16757130
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.16222926
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15354724
60NANOG_19829295_ChIP-Seq_ESCs_Human1.13560683
61SOX2_19829295_ChIP-Seq_ESCs_Human1.13560683
62ER_23166858_ChIP-Seq_MCF-7_Human1.12724647
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12182017
64P300_19829295_ChIP-Seq_ESCs_Human1.11172280
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10802124
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10178933
67XRN2_22483619_ChIP-Seq_HELA_Human1.09597828
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08797148
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08356126
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08183595
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08183104
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07957558
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05813325
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04831859
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04004593
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03931305
77AR_20517297_ChIP-Seq_VCAP_Human1.03173146
78TAF15_26573619_Chip-Seq_HEK293_Human1.02728525
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.02402464
80GATA1_22025678_ChIP-Seq_K562_Human1.01879742
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01694807
82CBP_20019798_ChIP-Seq_JUKART_Human1.01694807
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01673721
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00524452
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99637180
86NCOR_22424771_ChIP-Seq_293T_Human0.98160783
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96918577
88HTT_18923047_ChIP-ChIP_STHdh_Human0.96850878
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.92774843
90GATA3_26560356_Chip-Seq_TH2_Human0.92617996
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92491380
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.92303266
93IRF1_19129219_ChIP-ChIP_H3396_Human0.91338869
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88831011
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88364977
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87838548
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87313142
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87121894
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84897254
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.83652734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.27128714
2MP0008058_abnormal_DNA_repair2.92550998
3MP0002138_abnormal_hepatobiliary_system2.80022575
4MP0003786_premature_aging2.76265982
5MP0008877_abnormal_DNA_methylation2.67044768
6MP0001835_abnormal_antigen_presentation2.53851670
7MP0002837_dystrophic_cardiac_calcinosis2.49077619
8MP0006292_abnormal_olfactory_placode2.48779028
9MP0004957_abnormal_blastocyst_morpholog2.37799882
10MP0005084_abnormal_gallbladder_morpholo2.37626111
11MP0008872_abnormal_physiological_respon2.25569486
12MP0004147_increased_porphyrin_level2.23901726
13MP0010094_abnormal_chromosome_stability2.17406780
14MP0008875_abnormal_xenobiotic_pharmacok2.12863478
15MP0003718_maternal_effect2.08231210
16MP0005075_abnormal_melanosome_morpholog2.06000718
17MP0003567_abnormal_fetal_cardiomyocyte2.02937773
18MP0005645_abnormal_hypothalamus_physiol1.96681855
19MP0008007_abnormal_cellular_replicative1.86839852
20MP0003806_abnormal_nucleotide_metabolis1.86213695
21MP0006036_abnormal_mitochondrial_physio1.85218482
22MP0001968_abnormal_touch/_nociception1.82689133
23MP0005671_abnormal_response_to1.76986687
24MP0003693_abnormal_embryo_hatching1.76811054
25MP0000685_abnormal_immune_system1.74450716
26MP0003195_calcinosis1.73276568
27MP0003646_muscle_fatigue1.72756087
28MP0002938_white_spotting1.72682532
29MP0006035_abnormal_mitochondrial_morpho1.72422808
30MP0006072_abnormal_retinal_apoptosis1.64407285
31MP0009697_abnormal_copulation1.62492060
32MP0004145_abnormal_muscle_electrophysio1.59022336
33MP0001873_stomach_inflammation1.56098910
34MP0005408_hypopigmentation1.53227564
35MP0001293_anophthalmia1.50156789
36MP0009333_abnormal_splenocyte_physiolog1.37976256
37MP0008789_abnormal_olfactory_epithelium1.31355087
38MP0005551_abnormal_eye_electrophysiolog1.22519677
39MP0002736_abnormal_nociception_after1.22420960
40MP0003111_abnormal_nucleus_morphology1.22064627
41MP0003186_abnormal_redox_activity1.21946476
42MP0003077_abnormal_cell_cycle1.19345686
43MP0002163_abnormal_gland_morphology1.17926491
44MP0002166_altered_tumor_susceptibility1.17796074
45MP0002277_abnormal_respiratory_mucosa1.16823245
46MP0008057_abnormal_DNA_replication1.14964190
47MP0002006_tumorigenesis1.13258764
48MP0003011_delayed_dark_adaptation1.13090967
49MP0002148_abnormal_hypersensitivity_rea1.12911581
50MP0009785_altered_susceptibility_to1.12259481
51MP0002160_abnormal_reproductive_system1.08855606
52MP0004885_abnormal_endolymph1.08088299
53MP0005389_reproductive_system_phenotype1.06795610
54MP0010386_abnormal_urinary_bladder1.06325108
55MP0001501_abnormal_sleep_pattern1.06267767
56MP0001790_abnormal_immune_system1.03723193
57MP0005387_immune_system_phenotype1.03723193
58MP0002876_abnormal_thyroid_physiology1.02622844
59MP0005646_abnormal_pituitary_gland1.02442860
60MP0002693_abnormal_pancreas_physiology1.01212154
61MP0005379_endocrine/exocrine_gland_phen1.01141233
62MP0003763_abnormal_thymus_physiology0.98340206
63MP0000383_abnormal_hair_follicle0.96590273
64MP0000372_irregular_coat_pigmentation0.96525914
65MP0001529_abnormal_vocalization0.95877644
66MP0001800_abnormal_humoral_immune0.95160180
67MP0001661_extended_life_span0.94918477
68MP0005377_hearing/vestibular/ear_phenot0.93034466
69MP0003878_abnormal_ear_physiology0.93034466
70MP0004215_abnormal_myocardial_fiber0.92968734
71MP0001881_abnormal_mammary_gland0.92642641
72MP0003936_abnormal_reproductive_system0.91205803
73MP0000465_gastrointestinal_hemorrhage0.90587506
74MP0001853_heart_inflammation0.90323099
75MP0005332_abnormal_amino_acid0.89494215
76MP0005636_abnormal_mineral_homeostasis0.87534063
77MP0001348_abnormal_lacrimal_gland0.86711258
78MP0002210_abnormal_sex_determination0.86391239
79MP0005167_abnormal_blood-brain_barrier0.82207632
80MP0000689_abnormal_spleen_morphology0.81377716
81MP0001929_abnormal_gametogenesis0.81326822
82MP0000569_abnormal_digit_pigmentation0.76338704
83MP0001986_abnormal_taste_sensitivity0.75092855
84MP0001119_abnormal_female_reproductive0.75078172
85MP0002398_abnormal_bone_marrow0.75067963
86MP0001485_abnormal_pinna_reflex0.74856767
87MP0005410_abnormal_fertilization0.74498558
88MP0004142_abnormal_muscle_tone0.73982064
89MP0004084_abnormal_cardiac_muscle0.73529304
90MP0010678_abnormal_skin_adnexa0.73267311
91MP0000703_abnormal_thymus_morphology0.72523345
92MP0000653_abnormal_sex_gland0.71299923
93MP0001984_abnormal_olfaction0.71299629
94MP0008995_early_reproductive_senescence0.70460612
95MP0000631_abnormal_neuroendocrine_gland0.70065119
96MP0001905_abnormal_dopamine_level0.67765897
97MP0009379_abnormal_foot_pigmentation0.67172149
98MP0005253_abnormal_eye_physiology0.66786095
99MP0004484_altered_response_of0.66629447
100MP0001145_abnormal_male_reproductive0.66013571

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.63862679
2Lipid accumulation in hepatocytes (HP:0006561)4.34944569
3Mitochondrial inheritance (HP:0001427)4.13240508
4Increased CSF lactate (HP:0002490)4.08581835
5Acute necrotizing encephalopathy (HP:0006965)3.97549994
6Hepatocellular necrosis (HP:0001404)3.67107223
7Acute encephalopathy (HP:0006846)3.53136620
8Exertional dyspnea (HP:0002875)3.52367260
9Stomatitis (HP:0010280)3.50542185
10Abnormal mitochondria in muscle tissue (HP:0008316)3.47307700
11Hepatic necrosis (HP:0002605)3.45991827
12Progressive macrocephaly (HP:0004481)3.36315682
13Renal Fanconi syndrome (HP:0001994)3.31246605
14Increased serum lactate (HP:0002151)3.21927097
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18999355
16Colon cancer (HP:0003003)3.14924603
17Congenital, generalized hypertrichosis (HP:0004540)3.00500051
18Increased intramyocellular lipid droplets (HP:0012240)2.98471344
19Abnormality of the pons (HP:0007361)2.96082183
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94976211
21Aplastic anemia (HP:0001915)2.88616699
22Methylmalonic acidemia (HP:0002912)2.87359029
233-Methylglutaconic aciduria (HP:0003535)2.86579931
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72434023
25Abnormality of alanine metabolism (HP:0010916)2.72434023
26Hyperalaninemia (HP:0003348)2.72434023
27Cerebral edema (HP:0002181)2.67520533
28IgG deficiency (HP:0004315)2.65730207
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62878105
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62878105
31Hypoplasia of the pons (HP:0012110)2.62621988
32Respiratory difficulties (HP:0002880)2.58131537
33Abnormality of the labia minora (HP:0012880)2.52692214
34Methylmalonic aciduria (HP:0012120)2.50865384
35Increased muscle lipid content (HP:0009058)2.49321537
36Pancreatic cysts (HP:0001737)2.49111227
37Oligodactyly (hands) (HP:0001180)2.48709457
38Lactic acidosis (HP:0003128)2.47786908
39Congenital stationary night blindness (HP:0007642)2.45146020
40Glycosuria (HP:0003076)2.41332611
41Abnormality of urine glucose concentration (HP:0011016)2.41332611
42Nephronophthisis (HP:0000090)2.37802379
43Abolished electroretinogram (ERG) (HP:0000550)2.37151215
44Aplasia/hypoplasia of the uterus (HP:0008684)2.35388962
45Abnormality of midbrain morphology (HP:0002418)2.34775034
46Molar tooth sign on MRI (HP:0002419)2.34775034
47Abnormality of serum amino acid levels (HP:0003112)2.33585112
48Exercise intolerance (HP:0003546)2.25050432
49Hyperglycinemia (HP:0002154)2.24752005
50Optic disc pallor (HP:0000543)2.21898471
51Abnormality of macular pigmentation (HP:0008002)2.20418449
52Lethargy (HP:0001254)2.20242185
53True hermaphroditism (HP:0010459)2.19761973
54Central scotoma (HP:0000603)2.16083581
55Pancreatic fibrosis (HP:0100732)2.15695822
56Elevated erythrocyte sedimentation rate (HP:0003565)2.15684792
57Abnormality of the anterior horn cell (HP:0006802)2.13446314
58Degeneration of anterior horn cells (HP:0002398)2.13446314
59Cerebral hypomyelination (HP:0006808)2.13157352
60B lymphocytopenia (HP:0010976)2.11009087
61Abnormality of B cell number (HP:0010975)2.07118017
62Type II lissencephaly (HP:0007260)2.06818599
63Respiratory failure (HP:0002878)2.03103475
64Oligodactyly (HP:0012165)2.02178660
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01992795
66Pendular nystagmus (HP:0012043)2.01879491
67Abnormal respiratory motile cilium morphology (HP:0005938)2.00304005
68Abnormal respiratory epithelium morphology (HP:0012253)2.00304005
69Multiple enchondromatosis (HP:0005701)1.97043906
70Abnormality of the vitamin B12 metabolism (HP:0004341)1.96496958
71Leukodystrophy (HP:0002415)1.96024079
72Reduced antithrombin III activity (HP:0001976)1.93848349
73Absent thumb (HP:0009777)1.93269350
74Abnormality of vitamin B metabolism (HP:0004340)1.91699874
75Abnormal protein N-linked glycosylation (HP:0012347)1.90157618
76Abnormal protein glycosylation (HP:0012346)1.90157618
77Abnormal glycosylation (HP:0012345)1.90157618
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90157618
79Hypoproteinemia (HP:0003075)1.89707080
80Hyperphosphaturia (HP:0003109)1.88757637
81Large for gestational age (HP:0001520)1.88196045
82Pancytopenia (HP:0001876)1.86601533
83Abnormal rod and cone electroretinograms (HP:0008323)1.86068144
84Abnormality of the renal medulla (HP:0100957)1.84291809
85Abnormality of T cell physiology (HP:0011840)1.83993996
86Abnormality of renal resorption (HP:0011038)1.82844926
87Dyschromatopsia (HP:0007641)1.80702120
88Oral leukoplakia (HP:0002745)1.80359694
89Thyroiditis (HP:0100646)1.80347815
90Abnormality of serine family amino acid metabolism (HP:0010894)1.78752688
91Abnormality of glycine metabolism (HP:0010895)1.78752688
92Adactyly (HP:0009776)1.76023163
93Severe combined immunodeficiency (HP:0004430)1.75519626
94Meckel diverticulum (HP:0002245)1.75481923
95Abnormality of methionine metabolism (HP:0010901)1.75107839
96CNS demyelination (HP:0007305)1.75056593
97Abnormality of T cells (HP:0002843)1.72371108
98Hyperglycinuria (HP:0003108)1.71337918
99Supernumerary spleens (HP:0009799)1.70874669
100Decreased central vision (HP:0007663)1.70665226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.91048595
2EIF2AK33.44443073
3NUAK13.24202258
4MST43.15759110
5TSSK63.13386821
6PBK2.90201754
7EIF2AK12.80222501
8BMPR1B2.61049777
9BUB12.53051772
10TXK2.46128772
11VRK12.36931903
12ZAK2.27366839
13PLK32.22567903
14TAOK32.20406490
15TAF12.18701767
16NEK12.11160490
17STK162.03997008
18GRK12.00581265
19FRK1.94232958
20ADRBK21.64063356
21SRPK11.63586792
22WNK31.60162468
23NME11.59896094
24TNIK1.58125246
25TLK11.56549498
26MKNK21.55272583
27TGFBR11.51076652
28MKNK11.48832605
29PASK1.42763113
30TRIM281.41738931
31PLK41.39559681
32EIF2AK21.37024683
33MAP4K21.32783243
34NLK1.29677816
35DAPK11.21046031
36PLK21.19026227
37CDC71.18351221
38BCKDK1.18126452
39MAP3K121.17207941
40DAPK21.16024564
41STK38L1.12277131
42TEC1.05151464
43OXSR10.97701199
44MAP2K60.93050552
45CDK80.92595935
46PLK10.89566533
47MAPKAPK50.82638150
48CSNK1G10.81190940
49ACVR1B0.75980521
50ITK0.75232663
51BRSK20.73308001
52ALK0.72212264
53STK390.71936067
54CSNK1G30.68689385
55WEE10.65153559
56MAP3K40.63215047
57ATR0.61879610
58TTK0.59638860
59TIE10.59260878
60MAP4K10.59031481
61DYRK20.58425486
62CSNK1G20.53307340
63CSNK1A1L0.53152006
64PHKG20.52971412
65PHKG10.52971412
66MAPKAPK30.52165650
67WNK40.52005004
68INSRR0.50413425
69FGFR20.49441906
70NME20.48256713
71PINK10.47102078
72CHEK20.45322484
73IKBKE0.45294280
74MUSK0.44544744
75IKBKB0.42304971
76CSNK2A10.42223347
77DAPK30.41176743
78KIT0.41149602
79RPS6KA50.40620699
80CSNK2A20.39260905
81PRKCQ0.37834735
82RPS6KA40.36391939
83GRK50.36285163
84CDK190.34189029
85ATM0.33492156
86AURKB0.32994727
87SIK30.32840230
88PRKCE0.32680028
89STK40.32555915
90PRKCG0.32482733
91FGFR10.31922538
92CDK90.31729197
93PAK40.31720703
94CSNK1A10.29694896
95SYK0.29241453
96CDK70.28891379
97PRKCI0.22388382
98LCK0.22163512
99BCR0.21538215
100PAK30.21001362

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.99174149
2Protein export_Homo sapiens_hsa030603.21117377
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04026859
4Ribosome_Homo sapiens_hsa030102.97828285
5RNA polymerase_Homo sapiens_hsa030202.92407983
6Oxidative phosphorylation_Homo sapiens_hsa001902.77411231
7RNA degradation_Homo sapiens_hsa030182.35952262
8Parkinsons disease_Homo sapiens_hsa050122.34027073
9Basal transcription factors_Homo sapiens_hsa030222.19726294
10One carbon pool by folate_Homo sapiens_hsa006702.18697924
11Asthma_Homo sapiens_hsa053102.04372764
12Homologous recombination_Homo sapiens_hsa034401.99085459
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.81832346
14Allograft rejection_Homo sapiens_hsa053301.81265956
15Autoimmune thyroid disease_Homo sapiens_hsa053201.77070624
16Mismatch repair_Homo sapiens_hsa034301.74851830
17RNA transport_Homo sapiens_hsa030131.74231648
18Pyrimidine metabolism_Homo sapiens_hsa002401.71807773
19Propanoate metabolism_Homo sapiens_hsa006401.71080687
20Primary immunodeficiency_Homo sapiens_hsa053401.67267888
21DNA replication_Homo sapiens_hsa030301.66298394
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61483002
23Vitamin B6 metabolism_Homo sapiens_hsa007501.61331456
24Spliceosome_Homo sapiens_hsa030401.60244153
25Huntingtons disease_Homo sapiens_hsa050161.57156311
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55637648
27Non-homologous end-joining_Homo sapiens_hsa034501.50273850
28Base excision repair_Homo sapiens_hsa034101.49976263
29Type I diabetes mellitus_Homo sapiens_hsa049401.47855789
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.38859437
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34220027
32Alzheimers disease_Homo sapiens_hsa050101.33884645
33Selenocompound metabolism_Homo sapiens_hsa004501.33274188
34Linoleic acid metabolism_Homo sapiens_hsa005911.31614224
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30548230
36Fanconi anemia pathway_Homo sapiens_hsa034601.26936846
37Nucleotide excision repair_Homo sapiens_hsa034201.24966918
38Purine metabolism_Homo sapiens_hsa002301.20836084
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19171422
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18399841
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12720311
42Fatty acid elongation_Homo sapiens_hsa000621.11259065
43Tryptophan metabolism_Homo sapiens_hsa003801.10367336
44Graft-versus-host disease_Homo sapiens_hsa053321.09755849
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07580793
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06233466
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01371936
48Caffeine metabolism_Homo sapiens_hsa002320.94356369
49Phototransduction_Homo sapiens_hsa047440.93910115
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89792323
51Butanoate metabolism_Homo sapiens_hsa006500.88659402
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.85054923
53Hematopoietic cell lineage_Homo sapiens_hsa046400.79578351
54Peroxisome_Homo sapiens_hsa041460.77478703
55Nitrogen metabolism_Homo sapiens_hsa009100.76404541
56Pyruvate metabolism_Homo sapiens_hsa006200.75394764
57Ether lipid metabolism_Homo sapiens_hsa005650.73553647
58Antigen processing and presentation_Homo sapiens_hsa046120.69060858
59Rheumatoid arthritis_Homo sapiens_hsa053230.68063654
60Metabolic pathways_Homo sapiens_hsa011000.67807507
61mRNA surveillance pathway_Homo sapiens_hsa030150.66609476
62Cardiac muscle contraction_Homo sapiens_hsa042600.64337604
63Arachidonic acid metabolism_Homo sapiens_hsa005900.64199768
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62703167
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60396951
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58712474
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57368521
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56856255
69Collecting duct acid secretion_Homo sapiens_hsa049660.56763007
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54080362
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52320213
72Retinol metabolism_Homo sapiens_hsa008300.51124797
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48123324
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47773600
75Glutathione metabolism_Homo sapiens_hsa004800.47311869
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.46945860
77Basal cell carcinoma_Homo sapiens_hsa052170.45409533
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44508903
79Sulfur metabolism_Homo sapiens_hsa009200.43064677
80Chemical carcinogenesis_Homo sapiens_hsa052040.43020896
81Epstein-Barr virus infection_Homo sapiens_hsa051690.41924601
82Carbon metabolism_Homo sapiens_hsa012000.40040243
83Steroid biosynthesis_Homo sapiens_hsa001000.39936046
84Arginine and proline metabolism_Homo sapiens_hsa003300.39464043
85Folate biosynthesis_Homo sapiens_hsa007900.38837119
86p53 signaling pathway_Homo sapiens_hsa041150.38696106
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35312921
88Fat digestion and absorption_Homo sapiens_hsa049750.34518558
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34167142
90Systemic lupus erythematosus_Homo sapiens_hsa053220.34102251
91Cell cycle_Homo sapiens_hsa041100.33133692
92beta-Alanine metabolism_Homo sapiens_hsa004100.32885555
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.30982884
94Biosynthesis of amino acids_Homo sapiens_hsa012300.30616042
95Olfactory transduction_Homo sapiens_hsa047400.28444244
96T cell receptor signaling pathway_Homo sapiens_hsa046600.28142334
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.26406050
98Measles_Homo sapiens_hsa051620.26189117
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24315446
100Fatty acid degradation_Homo sapiens_hsa000710.23817551

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