

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.87888896 |
| 2 | proteasome assembly (GO:0043248) | 5.74219240 |
| 3 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.76700242 |
| 4 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.65315116 |
| 5 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.62346740 |
| 6 | rRNA modification (GO:0000154) | 4.60646439 |
| 7 | DNA double-strand break processing (GO:0000729) | 4.13574503 |
| 8 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.08189366 |
| 9 | ribosome assembly (GO:0042255) | 4.04678346 |
| 10 | GTP biosynthetic process (GO:0006183) | 4.02036281 |
| 11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.96669798 |
| 12 | rRNA methylation (GO:0031167) | 3.96397288 |
| 13 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.92381490 |
| 14 | ATP synthesis coupled proton transport (GO:0015986) | 3.92381490 |
| 15 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.92365971 |
| 16 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.89956661 |
| 17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.88863525 |
| 18 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.87968140 |
| 19 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.86484595 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.84856240 |
| 21 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.81596580 |
| 22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.81596580 |
| 23 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.81596580 |
| 24 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.78516321 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.78516321 |
| 26 | ribosomal small subunit assembly (GO:0000028) | 3.78505541 |
| 27 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.78425071 |
| 28 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.78425071 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.76709350 |
| 30 | chaperone-mediated protein transport (GO:0072321) | 3.70622382 |
| 31 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.64367406 |
| 32 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.63008841 |
| 33 | negative regulation of ligase activity (GO:0051352) | 3.63008841 |
| 34 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.61950988 |
| 35 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.61950988 |
| 36 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.61014478 |
| 37 | protein complex biogenesis (GO:0070271) | 3.60621288 |
| 38 | pseudouridine synthesis (GO:0001522) | 3.59530862 |
| 39 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.57466499 |
| 40 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.57173153 |
| 41 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.56230359 |
| 42 | termination of RNA polymerase III transcription (GO:0006386) | 3.56230359 |
| 43 | UTP biosynthetic process (GO:0006228) | 3.54223659 |
| 44 | respiratory chain complex IV assembly (GO:0008535) | 3.45316470 |
| 45 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.44780433 |
| 46 | termination of RNA polymerase I transcription (GO:0006363) | 3.42086078 |
| 47 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.41729844 |
| 48 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.38917890 |
| 49 | isotype switching (GO:0045190) | 3.38917890 |
| 50 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.38917890 |
| 51 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.36312625 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.33918501 |
| 53 | rRNA processing (GO:0006364) | 3.30299443 |
| 54 | protein neddylation (GO:0045116) | 3.27074215 |
| 55 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.26457237 |
| 56 | rRNA metabolic process (GO:0016072) | 3.24195564 |
| 57 | positive regulation of ligase activity (GO:0051351) | 3.24185148 |
| 58 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.23658864 |
| 59 | NADH dehydrogenase complex assembly (GO:0010257) | 3.23658864 |
| 60 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.23658864 |
| 61 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.18676116 |
| 62 | UTP metabolic process (GO:0046051) | 3.16430831 |
| 63 | ribosomal large subunit biogenesis (GO:0042273) | 3.16343800 |
| 64 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.11727920 |
| 65 | maturation of 5.8S rRNA (GO:0000460) | 3.10370123 |
| 66 | kynurenine metabolic process (GO:0070189) | 3.09613854 |
| 67 | cytochrome complex assembly (GO:0017004) | 3.07240457 |
| 68 | CTP biosynthetic process (GO:0006241) | 3.06985619 |
| 69 | CTP metabolic process (GO:0046036) | 3.06985619 |
| 70 | mitochondrial RNA metabolic process (GO:0000959) | 3.04918222 |
| 71 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.04535362 |
| 72 | spliceosomal snRNP assembly (GO:0000387) | 3.01666033 |
| 73 | ribosome biogenesis (GO:0042254) | 3.00791098 |
| 74 | positive regulation of cell cycle arrest (GO:0071158) | 2.96139847 |
| 75 | organelle disassembly (GO:1903008) | 2.95474167 |
| 76 | cytidine metabolic process (GO:0046087) | 2.95009194 |
| 77 | cytidine catabolic process (GO:0006216) | 2.95009194 |
| 78 | cytidine deamination (GO:0009972) | 2.95009194 |
| 79 | transcription from mitochondrial promoter (GO:0006390) | 2.93498568 |
| 80 | positive regulation of DNA recombination (GO:0045911) | 2.92975769 |
| 81 | translation (GO:0006412) | 2.91975475 |
| 82 | cullin deneddylation (GO:0010388) | 2.91159588 |
| 83 | amino acid salvage (GO:0043102) | 2.90987982 |
| 84 | L-methionine salvage (GO:0071267) | 2.90987982 |
| 85 | L-methionine biosynthetic process (GO:0071265) | 2.90987982 |
| 86 | tRNA processing (GO:0008033) | 2.90205610 |
| 87 | regulation of chronic inflammatory response (GO:0002676) | 2.90018473 |
| 88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.87779354 |
| 89 | chromatin remodeling at centromere (GO:0031055) | 2.86946654 |
| 90 | respiratory electron transport chain (GO:0022904) | 2.84516486 |
| 91 | regulation of immunoglobulin secretion (GO:0051023) | 2.84459705 |
| 92 | electron transport chain (GO:0022900) | 2.84442171 |
| 93 | cellular component biogenesis (GO:0044085) | 2.84419354 |
| 94 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.82537048 |
| 95 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.82480882 |
| 96 | IMP biosynthetic process (GO:0006188) | 2.81609689 |
| 97 | maturation of SSU-rRNA (GO:0030490) | 2.80964974 |
| 98 | positive regulation of interleukin-17 production (GO:0032740) | 2.80683771 |
| 99 | transcription from RNA polymerase I promoter (GO:0006360) | 2.79191640 |
| 100 | CENP-A containing nucleosome assembly (GO:0034080) | 2.78081065 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.19108763 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.07144851 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.72325472 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.13845641 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.16023280 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.07241070 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.98533734 |
| 8 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.88503352 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.83156313 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.82590331 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.65606962 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.62957795 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.61919871 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.56762068 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.54817893 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.45905106 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42126917 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 2.41861965 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.23115028 |
| 20 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.22403816 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.09945816 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.01997166 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.01406562 |
| 24 | EWS_26573619_Chip-Seq_HEK293_Human | 1.96124801 |
| 25 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94868198 |
| 26 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.86333758 |
| 27 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.85457927 |
| 28 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.81654703 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80456987 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.79214678 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.77905641 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.77596885 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63438478 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.62135584 |
| 35 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.58744833 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.54214731 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.51445962 |
| 38 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50865965 |
| 39 | FUS_26573619_Chip-Seq_HEK293_Human | 1.48990764 |
| 40 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.43004597 |
| 41 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.42072992 |
| 42 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41003317 |
| 43 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.38698346 |
| 44 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.34139015 |
| 45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.33341516 |
| 46 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.33288286 |
| 47 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.32870548 |
| 48 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.29665690 |
| 49 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.27146308 |
| 50 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.27146308 |
| 51 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.24592294 |
| 52 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23412307 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22212087 |
| 54 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.21619661 |
| 55 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.20233376 |
| 56 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.19335486 |
| 57 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.16757130 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.16222926 |
| 59 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.15354724 |
| 60 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.13560683 |
| 61 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.13560683 |
| 62 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.12724647 |
| 63 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.12182017 |
| 64 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11172280 |
| 65 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10802124 |
| 66 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.10178933 |
| 67 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.09597828 |
| 68 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.08797148 |
| 69 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.08356126 |
| 70 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.08183595 |
| 71 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08183104 |
| 72 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07957558 |
| 73 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.05813325 |
| 74 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.04831859 |
| 75 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.04004593 |
| 76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.03931305 |
| 77 | AR_20517297_ChIP-Seq_VCAP_Human | 1.03173146 |
| 78 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.02728525 |
| 79 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.02402464 |
| 80 | GATA1_22025678_ChIP-Seq_K562_Human | 1.01879742 |
| 81 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.01694807 |
| 82 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.01694807 |
| 83 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.01673721 |
| 84 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.00524452 |
| 85 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99637180 |
| 86 | NCOR_22424771_ChIP-Seq_293T_Human | 0.98160783 |
| 87 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96918577 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.96850878 |
| 89 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.92774843 |
| 90 | GATA3_26560356_Chip-Seq_TH2_Human | 0.92617996 |
| 91 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.92491380 |
| 92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92303266 |
| 93 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.91338869 |
| 94 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88831011 |
| 95 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88364977 |
| 96 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.87838548 |
| 97 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.87313142 |
| 98 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.87121894 |
| 99 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.84897254 |
| 100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.83652734 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 4.27128714 |
| 2 | MP0008058_abnormal_DNA_repair | 2.92550998 |
| 3 | MP0002138_abnormal_hepatobiliary_system | 2.80022575 |
| 4 | MP0003786_premature_aging | 2.76265982 |
| 5 | MP0008877_abnormal_DNA_methylation | 2.67044768 |
| 6 | MP0001835_abnormal_antigen_presentation | 2.53851670 |
| 7 | MP0002837_dystrophic_cardiac_calcinosis | 2.49077619 |
| 8 | MP0006292_abnormal_olfactory_placode | 2.48779028 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.37799882 |
| 10 | MP0005084_abnormal_gallbladder_morpholo | 2.37626111 |
| 11 | MP0008872_abnormal_physiological_respon | 2.25569486 |
| 12 | MP0004147_increased_porphyrin_level | 2.23901726 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.17406780 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.12863478 |
| 15 | MP0003718_maternal_effect | 2.08231210 |
| 16 | MP0005075_abnormal_melanosome_morpholog | 2.06000718 |
| 17 | MP0003567_abnormal_fetal_cardiomyocyte | 2.02937773 |
| 18 | MP0005645_abnormal_hypothalamus_physiol | 1.96681855 |
| 19 | MP0008007_abnormal_cellular_replicative | 1.86839852 |
| 20 | MP0003806_abnormal_nucleotide_metabolis | 1.86213695 |
| 21 | MP0006036_abnormal_mitochondrial_physio | 1.85218482 |
| 22 | MP0001968_abnormal_touch/_nociception | 1.82689133 |
| 23 | MP0005671_abnormal_response_to | 1.76986687 |
| 24 | MP0003693_abnormal_embryo_hatching | 1.76811054 |
| 25 | MP0000685_abnormal_immune_system | 1.74450716 |
| 26 | MP0003195_calcinosis | 1.73276568 |
| 27 | MP0003646_muscle_fatigue | 1.72756087 |
| 28 | MP0002938_white_spotting | 1.72682532 |
| 29 | MP0006035_abnormal_mitochondrial_morpho | 1.72422808 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.64407285 |
| 31 | MP0009697_abnormal_copulation | 1.62492060 |
| 32 | MP0004145_abnormal_muscle_electrophysio | 1.59022336 |
| 33 | MP0001873_stomach_inflammation | 1.56098910 |
| 34 | MP0005408_hypopigmentation | 1.53227564 |
| 35 | MP0001293_anophthalmia | 1.50156789 |
| 36 | MP0009333_abnormal_splenocyte_physiolog | 1.37976256 |
| 37 | MP0008789_abnormal_olfactory_epithelium | 1.31355087 |
| 38 | MP0005551_abnormal_eye_electrophysiolog | 1.22519677 |
| 39 | MP0002736_abnormal_nociception_after | 1.22420960 |
| 40 | MP0003111_abnormal_nucleus_morphology | 1.22064627 |
| 41 | MP0003186_abnormal_redox_activity | 1.21946476 |
| 42 | MP0003077_abnormal_cell_cycle | 1.19345686 |
| 43 | MP0002163_abnormal_gland_morphology | 1.17926491 |
| 44 | MP0002166_altered_tumor_susceptibility | 1.17796074 |
| 45 | MP0002277_abnormal_respiratory_mucosa | 1.16823245 |
| 46 | MP0008057_abnormal_DNA_replication | 1.14964190 |
| 47 | MP0002006_tumorigenesis | 1.13258764 |
| 48 | MP0003011_delayed_dark_adaptation | 1.13090967 |
| 49 | MP0002148_abnormal_hypersensitivity_rea | 1.12911581 |
| 50 | MP0009785_altered_susceptibility_to | 1.12259481 |
| 51 | MP0002160_abnormal_reproductive_system | 1.08855606 |
| 52 | MP0004885_abnormal_endolymph | 1.08088299 |
| 53 | MP0005389_reproductive_system_phenotype | 1.06795610 |
| 54 | MP0010386_abnormal_urinary_bladder | 1.06325108 |
| 55 | MP0001501_abnormal_sleep_pattern | 1.06267767 |
| 56 | MP0001790_abnormal_immune_system | 1.03723193 |
| 57 | MP0005387_immune_system_phenotype | 1.03723193 |
| 58 | MP0002876_abnormal_thyroid_physiology | 1.02622844 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.02442860 |
| 60 | MP0002693_abnormal_pancreas_physiology | 1.01212154 |
| 61 | MP0005379_endocrine/exocrine_gland_phen | 1.01141233 |
| 62 | MP0003763_abnormal_thymus_physiology | 0.98340206 |
| 63 | MP0000383_abnormal_hair_follicle | 0.96590273 |
| 64 | MP0000372_irregular_coat_pigmentation | 0.96525914 |
| 65 | MP0001529_abnormal_vocalization | 0.95877644 |
| 66 | MP0001800_abnormal_humoral_immune | 0.95160180 |
| 67 | MP0001661_extended_life_span | 0.94918477 |
| 68 | MP0005377_hearing/vestibular/ear_phenot | 0.93034466 |
| 69 | MP0003878_abnormal_ear_physiology | 0.93034466 |
| 70 | MP0004215_abnormal_myocardial_fiber | 0.92968734 |
| 71 | MP0001881_abnormal_mammary_gland | 0.92642641 |
| 72 | MP0003936_abnormal_reproductive_system | 0.91205803 |
| 73 | MP0000465_gastrointestinal_hemorrhage | 0.90587506 |
| 74 | MP0001853_heart_inflammation | 0.90323099 |
| 75 | MP0005332_abnormal_amino_acid | 0.89494215 |
| 76 | MP0005636_abnormal_mineral_homeostasis | 0.87534063 |
| 77 | MP0001348_abnormal_lacrimal_gland | 0.86711258 |
| 78 | MP0002210_abnormal_sex_determination | 0.86391239 |
| 79 | MP0005167_abnormal_blood-brain_barrier | 0.82207632 |
| 80 | MP0000689_abnormal_spleen_morphology | 0.81377716 |
| 81 | MP0001929_abnormal_gametogenesis | 0.81326822 |
| 82 | MP0000569_abnormal_digit_pigmentation | 0.76338704 |
| 83 | MP0001986_abnormal_taste_sensitivity | 0.75092855 |
| 84 | MP0001119_abnormal_female_reproductive | 0.75078172 |
| 85 | MP0002398_abnormal_bone_marrow | 0.75067963 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.74856767 |
| 87 | MP0005410_abnormal_fertilization | 0.74498558 |
| 88 | MP0004142_abnormal_muscle_tone | 0.73982064 |
| 89 | MP0004084_abnormal_cardiac_muscle | 0.73529304 |
| 90 | MP0010678_abnormal_skin_adnexa | 0.73267311 |
| 91 | MP0000703_abnormal_thymus_morphology | 0.72523345 |
| 92 | MP0000653_abnormal_sex_gland | 0.71299923 |
| 93 | MP0001984_abnormal_olfaction | 0.71299629 |
| 94 | MP0008995_early_reproductive_senescence | 0.70460612 |
| 95 | MP0000631_abnormal_neuroendocrine_gland | 0.70065119 |
| 96 | MP0001905_abnormal_dopamine_level | 0.67765897 |
| 97 | MP0009379_abnormal_foot_pigmentation | 0.67172149 |
| 98 | MP0005253_abnormal_eye_physiology | 0.66786095 |
| 99 | MP0004484_altered_response_of | 0.66629447 |
| 100 | MP0001145_abnormal_male_reproductive | 0.66013571 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.63862679 |
| 2 | Lipid accumulation in hepatocytes (HP:0006561) | 4.34944569 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.13240508 |
| 4 | Increased CSF lactate (HP:0002490) | 4.08581835 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.97549994 |
| 6 | Hepatocellular necrosis (HP:0001404) | 3.67107223 |
| 7 | Acute encephalopathy (HP:0006846) | 3.53136620 |
| 8 | Exertional dyspnea (HP:0002875) | 3.52367260 |
| 9 | Stomatitis (HP:0010280) | 3.50542185 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.47307700 |
| 11 | Hepatic necrosis (HP:0002605) | 3.45991827 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.36315682 |
| 13 | Renal Fanconi syndrome (HP:0001994) | 3.31246605 |
| 14 | Increased serum lactate (HP:0002151) | 3.21927097 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.18999355 |
| 16 | Colon cancer (HP:0003003) | 3.14924603 |
| 17 | Congenital, generalized hypertrichosis (HP:0004540) | 3.00500051 |
| 18 | Increased intramyocellular lipid droplets (HP:0012240) | 2.98471344 |
| 19 | Abnormality of the pons (HP:0007361) | 2.96082183 |
| 20 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.94976211 |
| 21 | Aplastic anemia (HP:0001915) | 2.88616699 |
| 22 | Methylmalonic acidemia (HP:0002912) | 2.87359029 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.86579931 |
| 24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.72434023 |
| 25 | Abnormality of alanine metabolism (HP:0010916) | 2.72434023 |
| 26 | Hyperalaninemia (HP:0003348) | 2.72434023 |
| 27 | Cerebral edema (HP:0002181) | 2.67520533 |
| 28 | IgG deficiency (HP:0004315) | 2.65730207 |
| 29 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.62878105 |
| 30 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.62878105 |
| 31 | Hypoplasia of the pons (HP:0012110) | 2.62621988 |
| 32 | Respiratory difficulties (HP:0002880) | 2.58131537 |
| 33 | Abnormality of the labia minora (HP:0012880) | 2.52692214 |
| 34 | Methylmalonic aciduria (HP:0012120) | 2.50865384 |
| 35 | Increased muscle lipid content (HP:0009058) | 2.49321537 |
| 36 | Pancreatic cysts (HP:0001737) | 2.49111227 |
| 37 | Oligodactyly (hands) (HP:0001180) | 2.48709457 |
| 38 | Lactic acidosis (HP:0003128) | 2.47786908 |
| 39 | Congenital stationary night blindness (HP:0007642) | 2.45146020 |
| 40 | Glycosuria (HP:0003076) | 2.41332611 |
| 41 | Abnormality of urine glucose concentration (HP:0011016) | 2.41332611 |
| 42 | Nephronophthisis (HP:0000090) | 2.37802379 |
| 43 | Abolished electroretinogram (ERG) (HP:0000550) | 2.37151215 |
| 44 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.35388962 |
| 45 | Abnormality of midbrain morphology (HP:0002418) | 2.34775034 |
| 46 | Molar tooth sign on MRI (HP:0002419) | 2.34775034 |
| 47 | Abnormality of serum amino acid levels (HP:0003112) | 2.33585112 |
| 48 | Exercise intolerance (HP:0003546) | 2.25050432 |
| 49 | Hyperglycinemia (HP:0002154) | 2.24752005 |
| 50 | Optic disc pallor (HP:0000543) | 2.21898471 |
| 51 | Abnormality of macular pigmentation (HP:0008002) | 2.20418449 |
| 52 | Lethargy (HP:0001254) | 2.20242185 |
| 53 | True hermaphroditism (HP:0010459) | 2.19761973 |
| 54 | Central scotoma (HP:0000603) | 2.16083581 |
| 55 | Pancreatic fibrosis (HP:0100732) | 2.15695822 |
| 56 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.15684792 |
| 57 | Abnormality of the anterior horn cell (HP:0006802) | 2.13446314 |
| 58 | Degeneration of anterior horn cells (HP:0002398) | 2.13446314 |
| 59 | Cerebral hypomyelination (HP:0006808) | 2.13157352 |
| 60 | B lymphocytopenia (HP:0010976) | 2.11009087 |
| 61 | Abnormality of B cell number (HP:0010975) | 2.07118017 |
| 62 | Type II lissencephaly (HP:0007260) | 2.06818599 |
| 63 | Respiratory failure (HP:0002878) | 2.03103475 |
| 64 | Oligodactyly (HP:0012165) | 2.02178660 |
| 65 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.01992795 |
| 66 | Pendular nystagmus (HP:0012043) | 2.01879491 |
| 67 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.00304005 |
| 68 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.00304005 |
| 69 | Multiple enchondromatosis (HP:0005701) | 1.97043906 |
| 70 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.96496958 |
| 71 | Leukodystrophy (HP:0002415) | 1.96024079 |
| 72 | Reduced antithrombin III activity (HP:0001976) | 1.93848349 |
| 73 | Absent thumb (HP:0009777) | 1.93269350 |
| 74 | Abnormality of vitamin B metabolism (HP:0004340) | 1.91699874 |
| 75 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.90157618 |
| 76 | Abnormal protein glycosylation (HP:0012346) | 1.90157618 |
| 77 | Abnormal glycosylation (HP:0012345) | 1.90157618 |
| 78 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.90157618 |
| 79 | Hypoproteinemia (HP:0003075) | 1.89707080 |
| 80 | Hyperphosphaturia (HP:0003109) | 1.88757637 |
| 81 | Large for gestational age (HP:0001520) | 1.88196045 |
| 82 | Pancytopenia (HP:0001876) | 1.86601533 |
| 83 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.86068144 |
| 84 | Abnormality of the renal medulla (HP:0100957) | 1.84291809 |
| 85 | Abnormality of T cell physiology (HP:0011840) | 1.83993996 |
| 86 | Abnormality of renal resorption (HP:0011038) | 1.82844926 |
| 87 | Dyschromatopsia (HP:0007641) | 1.80702120 |
| 88 | Oral leukoplakia (HP:0002745) | 1.80359694 |
| 89 | Thyroiditis (HP:0100646) | 1.80347815 |
| 90 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.78752688 |
| 91 | Abnormality of glycine metabolism (HP:0010895) | 1.78752688 |
| 92 | Adactyly (HP:0009776) | 1.76023163 |
| 93 | Severe combined immunodeficiency (HP:0004430) | 1.75519626 |
| 94 | Meckel diverticulum (HP:0002245) | 1.75481923 |
| 95 | Abnormality of methionine metabolism (HP:0010901) | 1.75107839 |
| 96 | CNS demyelination (HP:0007305) | 1.75056593 |
| 97 | Abnormality of T cells (HP:0002843) | 1.72371108 |
| 98 | Hyperglycinuria (HP:0003108) | 1.71337918 |
| 99 | Supernumerary spleens (HP:0009799) | 1.70874669 |
| 100 | Decreased central vision (HP:0007663) | 1.70665226 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.91048595 |
| 2 | EIF2AK3 | 3.44443073 |
| 3 | NUAK1 | 3.24202258 |
| 4 | MST4 | 3.15759110 |
| 5 | TSSK6 | 3.13386821 |
| 6 | PBK | 2.90201754 |
| 7 | EIF2AK1 | 2.80222501 |
| 8 | BMPR1B | 2.61049777 |
| 9 | BUB1 | 2.53051772 |
| 10 | TXK | 2.46128772 |
| 11 | VRK1 | 2.36931903 |
| 12 | ZAK | 2.27366839 |
| 13 | PLK3 | 2.22567903 |
| 14 | TAOK3 | 2.20406490 |
| 15 | TAF1 | 2.18701767 |
| 16 | NEK1 | 2.11160490 |
| 17 | STK16 | 2.03997008 |
| 18 | GRK1 | 2.00581265 |
| 19 | FRK | 1.94232958 |
| 20 | ADRBK2 | 1.64063356 |
| 21 | SRPK1 | 1.63586792 |
| 22 | WNK3 | 1.60162468 |
| 23 | NME1 | 1.59896094 |
| 24 | TNIK | 1.58125246 |
| 25 | TLK1 | 1.56549498 |
| 26 | MKNK2 | 1.55272583 |
| 27 | TGFBR1 | 1.51076652 |
| 28 | MKNK1 | 1.48832605 |
| 29 | PASK | 1.42763113 |
| 30 | TRIM28 | 1.41738931 |
| 31 | PLK4 | 1.39559681 |
| 32 | EIF2AK2 | 1.37024683 |
| 33 | MAP4K2 | 1.32783243 |
| 34 | NLK | 1.29677816 |
| 35 | DAPK1 | 1.21046031 |
| 36 | PLK2 | 1.19026227 |
| 37 | CDC7 | 1.18351221 |
| 38 | BCKDK | 1.18126452 |
| 39 | MAP3K12 | 1.17207941 |
| 40 | DAPK2 | 1.16024564 |
| 41 | STK38L | 1.12277131 |
| 42 | TEC | 1.05151464 |
| 43 | OXSR1 | 0.97701199 |
| 44 | MAP2K6 | 0.93050552 |
| 45 | CDK8 | 0.92595935 |
| 46 | PLK1 | 0.89566533 |
| 47 | MAPKAPK5 | 0.82638150 |
| 48 | CSNK1G1 | 0.81190940 |
| 49 | ACVR1B | 0.75980521 |
| 50 | ITK | 0.75232663 |
| 51 | BRSK2 | 0.73308001 |
| 52 | ALK | 0.72212264 |
| 53 | STK39 | 0.71936067 |
| 54 | CSNK1G3 | 0.68689385 |
| 55 | WEE1 | 0.65153559 |
| 56 | MAP3K4 | 0.63215047 |
| 57 | ATR | 0.61879610 |
| 58 | TTK | 0.59638860 |
| 59 | TIE1 | 0.59260878 |
| 60 | MAP4K1 | 0.59031481 |
| 61 | DYRK2 | 0.58425486 |
| 62 | CSNK1G2 | 0.53307340 |
| 63 | CSNK1A1L | 0.53152006 |
| 64 | PHKG2 | 0.52971412 |
| 65 | PHKG1 | 0.52971412 |
| 66 | MAPKAPK3 | 0.52165650 |
| 67 | WNK4 | 0.52005004 |
| 68 | INSRR | 0.50413425 |
| 69 | FGFR2 | 0.49441906 |
| 70 | NME2 | 0.48256713 |
| 71 | PINK1 | 0.47102078 |
| 72 | CHEK2 | 0.45322484 |
| 73 | IKBKE | 0.45294280 |
| 74 | MUSK | 0.44544744 |
| 75 | IKBKB | 0.42304971 |
| 76 | CSNK2A1 | 0.42223347 |
| 77 | DAPK3 | 0.41176743 |
| 78 | KIT | 0.41149602 |
| 79 | RPS6KA5 | 0.40620699 |
| 80 | CSNK2A2 | 0.39260905 |
| 81 | PRKCQ | 0.37834735 |
| 82 | RPS6KA4 | 0.36391939 |
| 83 | GRK5 | 0.36285163 |
| 84 | CDK19 | 0.34189029 |
| 85 | ATM | 0.33492156 |
| 86 | AURKB | 0.32994727 |
| 87 | SIK3 | 0.32840230 |
| 88 | PRKCE | 0.32680028 |
| 89 | STK4 | 0.32555915 |
| 90 | PRKCG | 0.32482733 |
| 91 | FGFR1 | 0.31922538 |
| 92 | CDK9 | 0.31729197 |
| 93 | PAK4 | 0.31720703 |
| 94 | CSNK1A1 | 0.29694896 |
| 95 | SYK | 0.29241453 |
| 96 | CDK7 | 0.28891379 |
| 97 | PRKCI | 0.22388382 |
| 98 | LCK | 0.22163512 |
| 99 | BCR | 0.21538215 |
| 100 | PAK3 | 0.21001362 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.99174149 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.21117377 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.04026859 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 2.97828285 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.92407983 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.77411231 |
| 7 | RNA degradation_Homo sapiens_hsa03018 | 2.35952262 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.34027073 |
| 9 | Basal transcription factors_Homo sapiens_hsa03022 | 2.19726294 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.18697924 |
| 11 | Asthma_Homo sapiens_hsa05310 | 2.04372764 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 1.99085459 |
| 13 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.81832346 |
| 14 | Allograft rejection_Homo sapiens_hsa05330 | 1.81265956 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.77070624 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.74851830 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.74231648 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.71807773 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.71080687 |
| 20 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.67267888 |
| 21 | DNA replication_Homo sapiens_hsa03030 | 1.66298394 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.61483002 |
| 23 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.61331456 |
| 24 | Spliceosome_Homo sapiens_hsa03040 | 1.60244153 |
| 25 | Huntingtons disease_Homo sapiens_hsa05016 | 1.57156311 |
| 26 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.55637648 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50273850 |
| 28 | Base excision repair_Homo sapiens_hsa03410 | 1.49976263 |
| 29 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.47855789 |
| 30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.38859437 |
| 31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.34220027 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.33884645 |
| 33 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.33274188 |
| 34 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.31614224 |
| 35 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.30548230 |
| 36 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.26936846 |
| 37 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.24966918 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.20836084 |
| 39 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.19171422 |
| 40 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.18399841 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.12720311 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.11259065 |
| 43 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.10367336 |
| 44 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.09755849 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.07580793 |
| 46 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.06233466 |
| 47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.01371936 |
| 48 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.94356369 |
| 49 | Phototransduction_Homo sapiens_hsa04744 | 0.93910115 |
| 50 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.89792323 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88659402 |
| 52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.85054923 |
| 53 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.79578351 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.77478703 |
| 55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.76404541 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.75394764 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.73553647 |
| 58 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.69060858 |
| 59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.68063654 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67807507 |
| 61 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.66609476 |
| 62 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.64337604 |
| 63 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.64199768 |
| 64 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62703167 |
| 65 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60396951 |
| 66 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.58712474 |
| 67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57368521 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.56856255 |
| 69 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.56763007 |
| 70 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54080362 |
| 71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52320213 |
| 72 | Retinol metabolism_Homo sapiens_hsa00830 | 0.51124797 |
| 73 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.48123324 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.47773600 |
| 75 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.47311869 |
| 76 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46945860 |
| 77 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.45409533 |
| 78 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44508903 |
| 79 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.43064677 |
| 80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.43020896 |
| 81 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.41924601 |
| 82 | Carbon metabolism_Homo sapiens_hsa01200 | 0.40040243 |
| 83 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.39936046 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.39464043 |
| 85 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38837119 |
| 86 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38696106 |
| 87 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35312921 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.34518558 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.34167142 |
| 90 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.34102251 |
| 91 | Cell cycle_Homo sapiens_hsa04110 | 0.33133692 |
| 92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32885555 |
| 93 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.30982884 |
| 94 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.30616042 |
| 95 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28444244 |
| 96 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.28142334 |
| 97 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.26406050 |
| 98 | Measles_Homo sapiens_hsa05162 | 0.26189117 |
| 99 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.24315446 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.23817551 |

