NPM1P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)7.16467714
2positive regulation of interleukin-17 production (GO:0032740)6.49667403
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.81467009
4cullin deneddylation (GO:0010388)4.86951039
5protein neddylation (GO:0045116)4.86869525
6DNA deamination (GO:0045006)4.75754707
7regulation of natural killer cell differentiation (GO:0032823)4.74048082
8positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.66748844
9positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.60781646
10regulation of chronic inflammatory response (GO:0002676)4.59225557
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.55486480
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.26091059
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.26091059
14protein deneddylation (GO:0000338)4.25157463
15lung secretory cell differentiation (GO:0061140)4.23239858
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.12422308
17viral mRNA export from host cell nucleus (GO:0046784)4.10815236
18inner mitochondrial membrane organization (GO:0007007)4.10766329
19regulation of double-strand break repair via homologous recombination (GO:0010569)4.07944805
20water-soluble vitamin biosynthetic process (GO:0042364)4.05257948
21regulation of isotype switching to IgG isotypes (GO:0048302)4.05250286
22regulation of interferon-gamma biosynthetic process (GO:0045072)4.03120969
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.02749923
24regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.96805981
25positive regulation of interleukin-10 production (GO:0032733)3.87727250
26rRNA modification (GO:0000154)3.81250944
27positive regulation of natural killer cell mediated immunity (GO:0002717)3.76182580
28metallo-sulfur cluster assembly (GO:0031163)3.70427114
29iron-sulfur cluster assembly (GO:0016226)3.70427114
30rRNA methylation (GO:0031167)3.69625526
31regulation of cellular amino acid metabolic process (GO:0006521)3.60927129
32regulation of interleukin-17 production (GO:0032660)3.53678516
33termination of RNA polymerase I transcription (GO:0006363)3.49547327
34maturation of 5.8S rRNA (GO:0000460)3.47480922
35respiratory chain complex IV assembly (GO:0008535)3.46899583
36regulation of interleukin-10 production (GO:0032653)3.46244393
37ribosome assembly (GO:0042255)3.38312943
38ribosome biogenesis (GO:0042254)3.36480306
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35141919
40DNA catabolic process, exonucleolytic (GO:0000738)3.34030070
41negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.33962305
42behavioral response to nicotine (GO:0035095)3.32885231
43folic acid-containing compound biosynthetic process (GO:0009396)3.31627834
44cytidine deamination (GO:0009972)3.27108777
45cytidine metabolic process (GO:0046087)3.27108777
46cytidine catabolic process (GO:0006216)3.27108777
47negative regulation of telomere maintenance (GO:0032205)3.25153234
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21313769
49ATP synthesis coupled proton transport (GO:0015986)3.21313769
50oxaloacetate metabolic process (GO:0006107)3.19755324
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16432961
52transcription elongation from RNA polymerase I promoter (GO:0006362)3.15817619
53DNA double-strand break processing (GO:0000729)3.15032289
54positive regulation of natural killer cell activation (GO:0032816)3.12989678
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10749461
56transcription from mitochondrial promoter (GO:0006390)3.10452135
57mucosal-associated lymphoid tissue development (GO:0048537)3.09153229
58Peyers patch development (GO:0048541)3.09153229
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04500194
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04001899
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04001899
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04001899
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03046930
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03046930
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00994073
66negative regulation of ligase activity (GO:0051352)3.00994073
67pyrimidine ribonucleoside catabolic process (GO:0046133)2.98318215
68regulation of proton transport (GO:0010155)2.97331807
69signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92872029
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.92872029
71cholesterol biosynthetic process (GO:0006695)2.92661146
72negative regulation of interleukin-10 production (GO:0032693)2.90218856
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89758581
74signal transduction involved in cell cycle checkpoint (GO:0072395)2.89060892
75negative regulation of B cell mediated immunity (GO:0002713)2.86688101
76negative regulation of immunoglobulin mediated immune response (GO:0002890)2.86688101
77leukocyte aggregation (GO:0070486)2.85959657
78L-fucose catabolic process (GO:0042355)2.83285339
79fucose catabolic process (GO:0019317)2.83285339
80L-fucose metabolic process (GO:0042354)2.83285339
81negative regulation of DNA recombination (GO:0045910)2.82690008
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78851437
83mitochondrial RNA metabolic process (GO:0000959)2.78759571
84regulation of cellular amine metabolic process (GO:0033238)2.77698931
85protein targeting to mitochondrion (GO:0006626)2.75513795
86positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.74639863
87positive regulation of cardiac muscle cell differentiation (GO:2000727)2.74273352
88isoprenoid biosynthetic process (GO:0008299)2.72466364
89T cell lineage commitment (GO:0002360)2.70478101
90tRNA processing (GO:0008033)2.68976398
91attachment of spindle microtubules to kinetochore (GO:0008608)2.68416847
92transcription initiation from RNA polymerase I promoter (GO:0006361)2.66543401
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.66328271
94regulation of natural killer cell mediated immunity (GO:0002715)2.66328271
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63030492
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.63030492
97NADH dehydrogenase complex assembly (GO:0010257)2.63030492
98amino acid activation (GO:0043038)2.62835881
99tRNA aminoacylation (GO:0043039)2.62835881
100positive regulation of cell fate commitment (GO:0010455)2.62806697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.05986298
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.84848549
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.27577667
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.52688459
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.78412344
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.73792888
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.69071323
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.58021875
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40839763
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34146899
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.16705598
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14259111
13E2F7_22180533_ChIP-Seq_HELA_Human2.95777407
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71460682
15VDR_23849224_ChIP-Seq_CD4+_Human2.65302077
16VDR_22108803_ChIP-Seq_LS180_Human2.63285587
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60075372
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.41929344
19ELK1_19687146_ChIP-ChIP_HELA_Human2.27855567
20FOXP3_21729870_ChIP-Seq_TREG_Human2.21574193
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06114621
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04811085
23GABP_19822575_ChIP-Seq_HepG2_Human2.00858094
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97578332
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93282964
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87269795
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.83845095
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80919613
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75371066
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73941545
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72781828
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71654519
33XRN2_22483619_ChIP-Seq_HELA_Human1.69238111
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.66662279
35TP53_22573176_ChIP-Seq_HFKS_Human1.63760928
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62527422
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58205679
38TTF2_22483619_ChIP-Seq_HELA_Human1.57968584
39ZNF274_21170338_ChIP-Seq_K562_Hela1.57714942
40MYC_18940864_ChIP-ChIP_HL60_Human1.50487952
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49100647
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.45075842
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42705631
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39768189
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35174978
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30663224
47IRF1_19129219_ChIP-ChIP_H3396_Human1.29492652
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26268480
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24622009
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24051961
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23440630
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20324457
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19913812
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18695550
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17153638
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.16363316
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16021017
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11123428
59DCP1A_22483619_ChIP-Seq_HELA_Human1.10503358
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09286158
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08817064
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08030721
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07554294
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06551996
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05312280
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02527550
67KDM5A_27292631_Chip-Seq_BREAST_Human1.00163520
68PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98717117
69FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97932172
70FOXA1_25329375_ChIP-Seq_VCAP_Human0.97932172
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92259116
72PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91528658
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88719534
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85653957
75MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84012946
76GATA3_26560356_Chip-Seq_TH2_Human0.84004805
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83876722
78NCOR_22424771_ChIP-Seq_293T_Human0.82502766
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81989800
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81539846
81P300_19829295_ChIP-Seq_ESCs_Human0.81291454
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78413529
83GATA1_22025678_ChIP-Seq_K562_Human0.78333557
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.77149217
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76795926
86EWS_26573619_Chip-Seq_HEK293_Human0.76298091
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75884409
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75214318
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.73985328
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72158807
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70129922
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69964084
93SALL4_22934838_ChIP-ChIP_CD34+_Human0.69910742
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69691990
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.68979166
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68464461
97PHF8_20622853_ChIP-Seq_HELA_Human0.67361225
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.66139948
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.65576398
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65433824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.28090943
2MP0001348_abnormal_lacrimal_gland3.20479299
3MP0002102_abnormal_ear_morphology3.10414460
4MP0004145_abnormal_muscle_electrophysio3.06791058
5MP0002138_abnormal_hepatobiliary_system3.05312068
6MP0001873_stomach_inflammation3.02774096
7MP0004147_increased_porphyrin_level3.00680514
8MP0008877_abnormal_DNA_methylation2.85853811
9MP0008995_early_reproductive_senescence2.77394606
10MP0003786_premature_aging2.58355990
11MP0003646_muscle_fatigue2.46554154
12MP0004742_abnormal_vestibular_system2.24264444
13MP0002638_abnormal_pupillary_reflex2.23186607
14MP0006292_abnormal_olfactory_placode2.21084744
15MP0005645_abnormal_hypothalamus_physiol2.15215010
16MP0002822_catalepsy2.09819225
17MP0008872_abnormal_physiological_respon2.08906320
18MP0003693_abnormal_embryo_hatching2.06109113
19MP0003718_maternal_effect2.05208373
20MP0008058_abnormal_DNA_repair2.00375409
21MP0001188_hyperpigmentation1.99188296
22MP0003567_abnormal_fetal_cardiomyocyte1.98577709
23MP0005084_abnormal_gallbladder_morpholo1.98119119
24MP0008961_abnormal_basal_metabolism1.87034282
25MP0001984_abnormal_olfaction1.82723335
26MP0001790_abnormal_immune_system1.77582194
27MP0005387_immune_system_phenotype1.77582194
28MP0009697_abnormal_copulation1.67695062
29MP0001502_abnormal_circadian_rhythm1.55581910
30MP0001835_abnormal_antigen_presentation1.49458618
31MP0003122_maternal_imprinting1.46859749
32MP0005167_abnormal_blood-brain_barrier1.46497130
33MP0008057_abnormal_DNA_replication1.45271356
34MP0004142_abnormal_muscle_tone1.45268734
35MP0008875_abnormal_xenobiotic_pharmacok1.43300950
36MP0001968_abnormal_touch/_nociception1.42307652
37MP0005085_abnormal_gallbladder_physiolo1.39928224
38MP0002876_abnormal_thyroid_physiology1.39492542
39MP0009745_abnormal_behavioral_response1.36393904
40MP0001501_abnormal_sleep_pattern1.32390394
41MP0005646_abnormal_pituitary_gland1.31511031
42MP0003878_abnormal_ear_physiology1.27936868
43MP0005377_hearing/vestibular/ear_phenot1.27936868
44MP0006276_abnormal_autonomic_nervous1.25172662
45MP0000372_irregular_coat_pigmentation1.24103460
46MP0001529_abnormal_vocalization1.23385690
47MP0005187_abnormal_penis_morphology1.23006021
48MP0006072_abnormal_retinal_apoptosis1.21814549
49MP0008789_abnormal_olfactory_epithelium1.19422198
50MP0005499_abnormal_olfactory_system1.19263356
51MP0005394_taste/olfaction_phenotype1.19263356
52MP0002163_abnormal_gland_morphology1.12735758
53MP0002006_tumorigenesis1.12529696
54MP0005647_abnormal_sex_gland1.11378656
55MP0001905_abnormal_dopamine_level1.11256128
56MP0001919_abnormal_reproductive_system1.09719483
57MP0000685_abnormal_immune_system1.09519782
58MP0004957_abnormal_blastocyst_morpholog1.09115365
59MP0003866_abnormal_defecation1.01271075
60MP0003763_abnormal_thymus_physiology0.98333606
61MP0005671_abnormal_response_to0.97754469
62MP0001663_abnormal_digestive_system0.97126641
63MP0005365_abnormal_bile_salt0.96877498
64MP0004133_heterotaxia0.95784891
65MP0002736_abnormal_nociception_after0.95781269
66MP0002938_white_spotting0.93798106
67MP0002928_abnormal_bile_duct0.92414967
68MP0003880_abnormal_central_pattern0.90102272
69MP0001243_abnormal_dermal_layer0.90064106
70MP0005551_abnormal_eye_electrophysiolog0.88908192
71MP0005410_abnormal_fertilization0.84649433
72MP0003119_abnormal_digestive_system0.84282709
73MP0006036_abnormal_mitochondrial_physio0.83747582
74MP0006082_CNS_inflammation0.81231631
75MP0000631_abnormal_neuroendocrine_gland0.80951587
76MP0001986_abnormal_taste_sensitivity0.80639087
77MP0001764_abnormal_homeostasis0.77899856
78MP0002272_abnormal_nervous_system0.77616595
79MP0003936_abnormal_reproductive_system0.76361066
80MP0001485_abnormal_pinna_reflex0.76176667
81MP0010094_abnormal_chromosome_stability0.75946961
82MP0002139_abnormal_hepatobiliary_system0.75286757
83MP0005389_reproductive_system_phenotype0.75021119
84MP0002166_altered_tumor_susceptibility0.74231460
85MP0009333_abnormal_splenocyte_physiolog0.74037320
86MP0000465_gastrointestinal_hemorrhage0.73498440
87MP0000013_abnormal_adipose_tissue0.72885695
88MP0001800_abnormal_humoral_immune0.71396337
89MP0004085_abnormal_heartbeat0.68855586
90MP0000627_abnormal_mammary_gland0.68544571
91MP0003959_abnormal_lean_body0.67821405
92MP0002277_abnormal_respiratory_mucosa0.67003915
93MP0005310_abnormal_salivary_gland0.65362557
94MP0003137_abnormal_impulse_conducting0.64596713
95MP0005636_abnormal_mineral_homeostasis0.64210724
96MP0005381_digestive/alimentary_phenotyp0.60799183
97MP0005000_abnormal_immune_tolerance0.59510227
98MP0005220_abnormal_exocrine_pancreas0.59145297
99MP0003879_abnormal_hair_cell0.57886034
100MP0000538_abnormal_urinary_bladder0.56837064

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.80625143
2Increased intramyocellular lipid droplets (HP:0012240)4.44499701
3Increased hepatocellular lipid droplets (HP:0006565)4.19088438
4Mitochondrial inheritance (HP:0001427)3.89972693
5Increased CSF lactate (HP:0002490)3.89146558
6Lipid accumulation in hepatocytes (HP:0006561)3.83183357
7Abnormality of alanine metabolism (HP:0010916)3.80401288
8Hyperalaninemia (HP:0003348)3.80401288
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.80401288
10Acute necrotizing encephalopathy (HP:0006965)3.72677767
11Increased muscle lipid content (HP:0009058)3.68135350
12Increased serum pyruvate (HP:0003542)3.64169222
13Abnormality of glycolysis (HP:0004366)3.63684441
14Abnormal mitochondria in muscle tissue (HP:0008316)3.63103983
15Exertional dyspnea (HP:0002875)3.31869301
16Abnormality of the labia minora (HP:0012880)3.30562916
17Hepatocellular necrosis (HP:0001404)3.26378298
18Chronic diarrhea (HP:0002028)3.24639281
19Hepatic necrosis (HP:0002605)3.06653657
20Acute encephalopathy (HP:0006846)3.01766646
21Abnormality of the pons (HP:0007361)2.99439033
22Increased serum lactate (HP:0002151)2.96510155
23Progressive macrocephaly (HP:0004481)2.95898091
24Parakeratosis (HP:0001036)2.94167172
25Multiple enchondromatosis (HP:0005701)2.86254097
26Hypoplasia of the pons (HP:0012110)2.81052833
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80948817
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80948817
29Thyroid-stimulating hormone excess (HP:0002925)2.78357210
30Pendular nystagmus (HP:0012043)2.78273584
31Methylmalonic aciduria (HP:0012120)2.77813318
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76043163
33Renal Fanconi syndrome (HP:0001994)2.69721353
34Oral leukoplakia (HP:0002745)2.66884867
35Abolished electroretinogram (ERG) (HP:0000550)2.63498186
36Pancreatic cysts (HP:0001737)2.61600473
37Respiratory difficulties (HP:0002880)2.60183941
38Optic disc pallor (HP:0000543)2.57252619
39Unilateral renal agenesis (HP:0000122)2.44183525
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37854771
41Lactic acidosis (HP:0003128)2.37552547
42Colon cancer (HP:0003003)2.37006487
43Cerebral edema (HP:0002181)2.32418016
44Adactyly (HP:0009776)2.31506150
45Abnormality of DNA repair (HP:0003254)2.30186408
46Genetic anticipation (HP:0003743)2.27980024
47Respiratory failure (HP:0002878)2.26226446
48Tubulointerstitial nephritis (HP:0001970)2.25339671
49Hyperglycinemia (HP:0002154)2.24741844
50Neonatal respiratory distress (HP:0002643)2.23764411
51Pancytopenia (HP:0001876)2.21996316
52IgG deficiency (HP:0004315)2.19791573
53Abnormality of serum amino acid levels (HP:0003112)2.18329149
54Abnormality of B cell number (HP:0010975)2.17519578
55Neuroblastoma (HP:0003006)2.16199349
56Primitive neuroectodermal tumor (HP:0030065)2.16199349
57Neuroblastic tumors (HP:0004376)2.16199349
58Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.16199349
59B lymphocytopenia (HP:0010976)2.13792283
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08634749
61Lethargy (HP:0001254)2.08615571
62Abnormal biliary tract physiology (HP:0012439)2.05336915
63Bile duct proliferation (HP:0001408)2.05336915
64Cerebellar dysplasia (HP:0007033)2.03676820
65Methylmalonic acidemia (HP:0002912)2.00565107
66Glycosuria (HP:0003076)1.99132097
67Abnormality of urine glucose concentration (HP:0011016)1.99132097
68Thyroiditis (HP:0100646)1.98609171
69Abnormality of glycine metabolism (HP:0010895)1.97653010
70Abnormality of serine family amino acid metabolism (HP:0010894)1.97653010
71Megalencephaly (HP:0001355)1.96076944
72Exercise intolerance (HP:0003546)1.95192695
73Severe combined immunodeficiency (HP:0004430)1.94587737
74CNS demyelination (HP:0007305)1.92033867
75Neoplasm of the adrenal gland (HP:0100631)1.91723616
76Hyperphosphaturia (HP:0003109)1.89572086
77Hypoproteinemia (HP:0003075)1.86268693
78Constricted visual fields (HP:0001133)1.84653804
79Severe muscular hypotonia (HP:0006829)1.84197042
80Increased IgM level (HP:0003496)1.84160378
81Pancreatic fibrosis (HP:0100732)1.83309861
82Duplicated collecting system (HP:0000081)1.83010037
83Type II lissencephaly (HP:0007260)1.81752176
84True hermaphroditism (HP:0010459)1.79568122
85Chorioretinal atrophy (HP:0000533)1.79121525
86Microvesicular hepatic steatosis (HP:0001414)1.78690115
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76792177
88Cerebral palsy (HP:0100021)1.72927523
89Nephronophthisis (HP:0000090)1.71561692
90Hyperglycinuria (HP:0003108)1.71267999
91Cystic liver disease (HP:0006706)1.70350347
92Abnormality of the renal collecting system (HP:0004742)1.69897789
93Optic nerve coloboma (HP:0000588)1.69794016
94Papillary thyroid carcinoma (HP:0002895)1.69618953
95Upper limb muscle weakness (HP:0003484)1.67925650
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67820150
97Cerebral hypomyelination (HP:0006808)1.66960262
98Abnormality of the anterior horn cell (HP:0006802)1.64039929
99Degeneration of anterior horn cells (HP:0002398)1.64039929
100Fused cervical vertebrae (HP:0002949)1.62742975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.51132145
2TSSK64.83293191
3EIF2AK33.59840076
4EIF2AK13.48614137
5BUB13.36690837
6NEK13.19156416
7TLK12.97956375
8ZAK2.50190445
9VRK22.29012835
10BCKDK2.14322037
11PBK2.13505417
12TAF12.01771965
13MAP4K21.99024396
14SRPK11.93600187
15PAK61.89569555
16CDK81.87937061
17BCR1.69045096
18SIK31.63014664
19VRK11.60769824
20PDK21.54291792
21ADRBK21.44376033
22BMPR1B1.40253357
23CSNK1A1L1.36421467
24WNK41.30765607
25DYRK21.27200974
26PAK31.16433182
27PLK31.16271847
28GRK11.13755517
29NUAK11.11872395
30MST41.10861988
31CSNK1G11.09569398
32CSNK1G31.06914750
33FRK1.04204870
34EPHA41.01864916
35RAF10.98400254
36NME10.95634953
37MAP3K120.92778472
38KDR0.90117624
39PHKG10.87304648
40PHKG20.87304648
41TXK0.87165923
42ALK0.86643496
43CSNK1G20.85543270
44CLK10.85103910
45CDC70.82552938
46MKNK10.81692168
47MAP2K60.78311050
48TAOK30.74246302
49PRKAA20.74166879
50WNK30.71058899
51RPS6KA50.69998216
52CSNK1E0.68555171
53ATR0.67747237
54CAMKK20.65717541
55AURKB0.61758724
56TRIM280.60897756
57EIF2AK20.59889859
58CDK90.57843933
59MKNK20.56454561
60AKT20.56261630
61PLK10.55907884
62DAPK10.55501273
63AURKA0.54016586
64INSRR0.52064291
65CSNK1A10.51398643
66STK240.50154163
67ITK0.48753067
68LIMK10.48632146
69CSNK2A20.48280933
70CAMK2A0.47893661
71SIK20.47397351
72CDK40.45605954
73CSNK1D0.44267775
74PRKCG0.44007412
75PAK10.43059326
76CCNB10.38799201
77TESK20.37844680
78MAPKAPK50.37573871
79PRKCQ0.35778365
80GRK50.34410356
81PRKCB0.33295816
82SGK10.33275478
83DAPK30.32941122
84MAPK130.32767843
85PRKAA10.32752953
86STK390.32621622
87CHEK10.32380733
88OXSR10.32248813
89KSR20.31875214
90CSNK2A10.31136933
91STK38L0.30607396
92PRKACA0.30022433
93BTK0.28494210
94IKBKB0.28024308
95MYLK0.27812819
96ATM0.26457877
97PRKCA0.26085143
98PRKACB0.25470959
99NEK20.24290592
100LCK0.23795596

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.68026018
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28356035
3Oxidative phosphorylation_Homo sapiens_hsa001902.98499565
4Protein export_Homo sapiens_hsa030602.93105664
5Sulfur metabolism_Homo sapiens_hsa009202.92255975
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.84643065
7Parkinsons disease_Homo sapiens_hsa050122.66300255
8RNA polymerase_Homo sapiens_hsa030202.59974885
9One carbon pool by folate_Homo sapiens_hsa006702.25973266
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10038816
11Nucleotide excision repair_Homo sapiens_hsa034202.09637176
12RNA transport_Homo sapiens_hsa030131.99835940
13Spliceosome_Homo sapiens_hsa030401.95953290
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94164204
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88037623
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82457602
17Basal transcription factors_Homo sapiens_hsa030221.82432811
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78017738
19Steroid biosynthesis_Homo sapiens_hsa001001.77751547
20Mismatch repair_Homo sapiens_hsa034301.77105503
21DNA replication_Homo sapiens_hsa030301.68813265
22Systemic lupus erythematosus_Homo sapiens_hsa053221.68372398
23Sulfur relay system_Homo sapiens_hsa041221.65122851
24Nitrogen metabolism_Homo sapiens_hsa009101.62704975
25Huntingtons disease_Homo sapiens_hsa050161.61982089
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54047508
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45275027
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.45045486
29Propanoate metabolism_Homo sapiens_hsa006401.44797188
30RNA degradation_Homo sapiens_hsa030181.42974865
31Alzheimers disease_Homo sapiens_hsa050101.34181736
32Selenocompound metabolism_Homo sapiens_hsa004501.33995735
33Base excision repair_Homo sapiens_hsa034101.30810867
34Primary immunodeficiency_Homo sapiens_hsa053401.27574510
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25892215
36Phototransduction_Homo sapiens_hsa047441.25167967
37Homologous recombination_Homo sapiens_hsa034401.20362029
38Pyrimidine metabolism_Homo sapiens_hsa002401.17528680
39Alcoholism_Homo sapiens_hsa050341.08318408
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.06997286
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06465164
42Ribosome_Homo sapiens_hsa030101.00586026
43Cardiac muscle contraction_Homo sapiens_hsa042600.99590100
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99187500
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95039024
46Allograft rejection_Homo sapiens_hsa053300.92047311
47Collecting duct acid secretion_Homo sapiens_hsa049660.87735920
48Autoimmune thyroid disease_Homo sapiens_hsa053200.87721171
49Non-homologous end-joining_Homo sapiens_hsa034500.86458827
50Peroxisome_Homo sapiens_hsa041460.85390549
51Tryptophan metabolism_Homo sapiens_hsa003800.84536248
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84515387
53Asthma_Homo sapiens_hsa053100.83614227
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80942384
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79333173
56Purine metabolism_Homo sapiens_hsa002300.79032159
57Fanconi anemia pathway_Homo sapiens_hsa034600.75735695
58Butanoate metabolism_Homo sapiens_hsa006500.73386256
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.70260311
60Type I diabetes mellitus_Homo sapiens_hsa049400.66819847
61Vitamin B6 metabolism_Homo sapiens_hsa007500.65091680
62Carbon metabolism_Homo sapiens_hsa012000.64410025
63Pyruvate metabolism_Homo sapiens_hsa006200.63626968
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63260374
65Metabolic pathways_Homo sapiens_hsa011000.63185301
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62033922
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59732492
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56895821
69Arginine biosynthesis_Homo sapiens_hsa002200.54652663
70mRNA surveillance pathway_Homo sapiens_hsa030150.52545177
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52392707
72Fatty acid degradation_Homo sapiens_hsa000710.48135210
73p53 signaling pathway_Homo sapiens_hsa041150.47255869
74Biosynthesis of amino acids_Homo sapiens_hsa012300.46732674
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46586156
76Hematopoietic cell lineage_Homo sapiens_hsa046400.46480149
77Ether lipid metabolism_Homo sapiens_hsa005650.45709455
78Synaptic vesicle cycle_Homo sapiens_hsa047210.45470404
79Mineral absorption_Homo sapiens_hsa049780.44363122
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43668139
81Cell cycle_Homo sapiens_hsa041100.41721614
82Caffeine metabolism_Homo sapiens_hsa002320.40754303
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.39737088
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39663229
85Rheumatoid arthritis_Homo sapiens_hsa053230.39264483
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39222323
87Viral carcinogenesis_Homo sapiens_hsa052030.37109867
88Graft-versus-host disease_Homo sapiens_hsa053320.34878016
89Fat digestion and absorption_Homo sapiens_hsa049750.34575316
90Retinol metabolism_Homo sapiens_hsa008300.33827156
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31075567
92Vibrio cholerae infection_Homo sapiens_hsa051100.30882943
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30615084
94Vitamin digestion and absorption_Homo sapiens_hsa049770.29734392
95Nicotine addiction_Homo sapiens_hsa050330.28853557
96Arginine and proline metabolism_Homo sapiens_hsa003300.27557513
97Linoleic acid metabolism_Homo sapiens_hsa005910.24277077
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24080911
99beta-Alanine metabolism_Homo sapiens_hsa004100.23868456
100Legionellosis_Homo sapiens_hsa051340.23222858

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