NPM1P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of type 2 immune response (GO:0002829)9.96273459
2activation of protein kinase A activity (GO:0034199)9.66408587
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.27695105
4seminiferous tubule development (GO:0072520)9.08482087
5cAMP biosynthetic process (GO:0006171)8.61870743
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.44608228
7detection of chemical stimulus involved in sensory perception (GO:0050907)8.32072404
8enteric nervous system development (GO:0048484)7.52466325
9regulation of protein sumoylation (GO:0033233)6.99994893
10synaptic transmission, dopaminergic (GO:0001963)6.92118435
11dendritic spine morphogenesis (GO:0060997)6.75094131
12righting reflex (GO:0060013)6.59216746
13positive regulation of mitochondrial fission (GO:0090141)6.53490000
14positive regulation of T-helper 1 type immune response (GO:0002827)6.37361756
15heterotypic cell-cell adhesion (GO:0034113)6.14473116
16detection of chemical stimulus (GO:0009593)5.94803643
17hepatocyte apoptotic process (GO:0097284)5.86917197
18positive regulation of T-helper cell differentiation (GO:0045624)5.83923363
19arachidonic acid secretion (GO:0050482)5.82834756
20icosanoid secretion (GO:0032309)5.82834756
21endothelial cell differentiation (GO:0045446)5.78358860
22phosphatidylinositol acyl-chain remodeling (GO:0036149)5.25283160
23negative regulation of alpha-beta T cell activation (GO:0046636)5.14440208
24drug transmembrane transport (GO:0006855)4.95891774
25retina layer formation (GO:0010842)4.91150090
26phosphatidylserine acyl-chain remodeling (GO:0036150)4.87689568
27icosanoid transport (GO:0071715)4.78744996
28fatty acid derivative transport (GO:1901571)4.78744996
29regulation of mitochondrial fission (GO:0090140)4.74034186
30phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.65828964
31neural tube formation (GO:0001841)4.62136440
32regulation of T-helper 1 type immune response (GO:0002825)4.55143739
33chemosensory behavior (GO:0007635)4.53125882
34embryonic digestive tract morphogenesis (GO:0048557)4.51212381
35pre-miRNA processing (GO:0031054)4.50335803
36neuronal ion channel clustering (GO:0045161)4.45615832
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.42204315
38attachment of spindle microtubules to kinetochore (GO:0008608)4.42130261
39nephron tubule morphogenesis (GO:0072078)4.36826801
40nephron epithelium morphogenesis (GO:0072088)4.36826801
41cyclic purine nucleotide metabolic process (GO:0052652)4.36480936
42hyaluronan catabolic process (GO:0030214)4.32126278
43regulation of T-helper cell differentiation (GO:0045622)4.31826914
44cilium or flagellum-dependent cell motility (GO:0001539)4.24327233
45energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.23800711
46ATP hydrolysis coupled proton transport (GO:0015991)4.23800711
47cyclic nucleotide biosynthetic process (GO:0009190)4.23033908
48regulation of cAMP-mediated signaling (GO:0043949)4.17189605
49vocalization behavior (GO:0071625)4.07457098
50regulation of type 2 immune response (GO:0002828)4.04090856
51negative regulation of actin filament bundle assembly (GO:0032232)4.03853247
52response to dietary excess (GO:0002021)4.01057622
53positive regulation of membrane potential (GO:0045838)4.00529060
54cellular response to glucagon stimulus (GO:0071377)3.91595299
55positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.89637538
56water transport (GO:0006833)3.89548173
57cAMP metabolic process (GO:0046058)3.89356294
58protein localization to synapse (GO:0035418)3.83268533
59negative regulation of T cell differentiation (GO:0045581)3.77238419
60dendritic spine organization (GO:0097061)3.67627998
61sulfur amino acid catabolic process (GO:0000098)3.67570244
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.57555673
63leukotriene biosynthetic process (GO:0019370)3.56149368
64monoamine transport (GO:0015844)3.55700033
65fluid transport (GO:0042044)3.51044663
66cellular zinc ion homeostasis (GO:0006882)3.50459807
67positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.45304298
68cellular response to ATP (GO:0071318)3.42797237
69regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.41090939
70mitochondrial fusion (GO:0008053)3.39436096
71phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.39364946
72drug transport (GO:0015893)3.33427924
73positive regulation of alpha-beta T cell differentiation (GO:0046638)3.31321723
74cytoskeletal anchoring at plasma membrane (GO:0007016)3.28017354
75positive regulation of protein targeting to membrane (GO:0090314)3.26180937
76left/right axis specification (GO:0070986)3.24678536
77sequestering of metal ion (GO:0051238)3.19341101
78adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.18731252
79prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.16740945
80renal tubule morphogenesis (GO:0061333)3.13177647
81negative regulation of homotypic cell-cell adhesion (GO:0034111)3.12017662
82negative regulation of astrocyte differentiation (GO:0048712)3.10418186
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09561372
84adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.05369236
85positive regulation of steroid hormone secretion (GO:2000833)3.04262205
86regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.99035089
87reflex (GO:0060004)2.98811924
88positive regulation of dendritic spine development (GO:0060999)2.91029993
89positive regulation of organ growth (GO:0046622)2.89927598
90response to glucagon (GO:0033762)2.88748061
91neurofilament cytoskeleton organization (GO:0060052)2.88700888
92tooth mineralization (GO:0034505)13.5878488
93detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.2791592
94negative regulation of T-helper cell differentiation (GO:0045623)11.5349999
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.5349999
96positive regulation of protein sumoylation (GO:0033235)11.2526350
97protein K11-linked deubiquitination (GO:0035871)10.4014411
98regulation of T-helper 1 cell differentiation (GO:0045625)10.1912259
99positive regulation of RNA splicing (GO:0033120)10.0957718
100regulation of T-helper 2 cell differentiation (GO:0045628)10.0312582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.61524753
2AR_21572438_ChIP-Seq_LNCaP_Human4.79802491
3IGF1R_20145208_ChIP-Seq_DFB_Human4.58816565
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.52937858
5VDR_22108803_ChIP-Seq_LS180_Human4.20268200
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.98630838
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16140435
8TP53_16413492_ChIP-PET_HCT116_Human2.01671351
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00502221
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse11.1164480
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94289734
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89415754
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87416751
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.87416751
15YY1_22570637_ChIP-Seq_MALME-3M_Human1.84429921
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79950519
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72024746
18DROSHA_22980978_ChIP-Seq_HELA_Human1.65286799
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.60765452
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58921512
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.57713984
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56941005
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.56066028
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.54335733
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53228306
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51846261
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50611183
28GATA1_19941826_ChIP-Seq_K562_Human1.49142186
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43134718
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.43132995
31RNF2_27304074_Chip-Seq_NSC_Mouse1.42245363
32GBX2_23144817_ChIP-Seq_PC3_Human1.41789070
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37686520
34EGR1_19032775_ChIP-ChIP_M12_Human1.34226710
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31616855
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.31512245
37ER_23166858_ChIP-Seq_MCF-7_Human1.29745488
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27921775
39EZH2_22144423_ChIP-Seq_EOC_Human1.27471851
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26562325
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.24009648
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.23367732
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22347809
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.21754304
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20463014
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20106650
47TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.19662933
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18978777
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17099276
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15939431
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15471659
52RXR_22108803_ChIP-Seq_LS180_Human1.14606936
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.12172206
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11800273
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09113491
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08107712
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07882232
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05861439
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05861439
60SMAD4_21741376_ChIP-Seq_HESCs_Human1.05467596
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.04078791
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.03343268
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.02720973
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01356116
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01269776
66CJUN_26792858_Chip-Seq_BT549_Human1.00277723
67STAT3_23295773_ChIP-Seq_U87_Human0.97846435
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97708739
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97708739
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97708739
71ZNF274_21170338_ChIP-Seq_K562_Hela0.96522196
72CMYC_18555785_Chip-Seq_ESCs_Mouse0.95464632
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95418158
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.94334197
75BCAT_22108803_ChIP-Seq_LS180_Human0.93672492
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93440588
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92705554
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91808849
79TBL1_22424771_ChIP-Seq_293T_Human0.90684198
80CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89750563
81PHF8_20622853_ChIP-Seq_HELA_Human0.88205384
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87980167
83SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87401030
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87099575
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87057173
86E2F1_18555785_Chip-Seq_ESCs_Mouse0.87020461
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86743234
88SMAD4_21799915_ChIP-Seq_A2780_Human0.85795645
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.85777635
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.84232095
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84097716
92CBP_20019798_ChIP-Seq_JUKART_Human0.84097716
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83698810
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82899626
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.81367797
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80987892
97KLF4_18555785_Chip-Seq_ESCs_Mouse0.80786449
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80719050
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79942251
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.78548856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism8.73581225
2MP0003252_abnormal_bile_duct4.41145457
3MP0004130_abnormal_muscle_cell4.26821951
4MP0004264_abnormal_extraembryonic_tissu3.80824325
5MP0002928_abnormal_bile_duct3.40817304
6MP0004133_heterotaxia3.23186976
7MP0005408_hypopigmentation2.51399858
8MP0001270_distended_abdomen2.42944192
9MP0006072_abnormal_retinal_apoptosis2.30153301
10MP0002751_abnormal_autonomic_nervous2.16787075
11MP0005448_abnormal_energy_balance2.05124641
12MP0005084_abnormal_gallbladder_morpholo12.8560516
13MP0004272_abnormal_basement_membrane1.96769933
14MP0005220_abnormal_exocrine_pancreas1.82968716
15MP0003329_amyloid_beta_deposits1.79499656
16MP0003943_abnormal_hepatobiliary_system1.49611022
17MP0005379_endocrine/exocrine_gland_phen1.42833778
18MP0001529_abnormal_vocalization1.39918523
19MP0005165_increased_susceptibility_to1.37804417
20MP0001958_emphysema1.28814751
21MP0009764_decreased_sensitivity_to1.24158560
22MP0003718_maternal_effect1.20778490
23MP0005646_abnormal_pituitary_gland1.18511432
24MP0000604_amyloidosis1.15685691
25MP0002822_catalepsy1.09809538
26MP0000371_diluted_coat_color1.08080951
27MP0008569_lethality_at_weaning1.00220696
28MP0000465_gastrointestinal_hemorrhage0.95534229
29MP0001944_abnormal_pancreas_morphology0.92427504
30MP0003638_abnormal_response/metabolism_0.89904421
31MP0002572_abnormal_emotion/affect_behav0.89125136
32MP0001905_abnormal_dopamine_level0.89006927
33MP0000470_abnormal_stomach_morphology0.88646573
34MP0002138_abnormal_hepatobiliary_system0.85174805
35MP0005083_abnormal_biliary_tract0.81154386
36MP0005164_abnormal_response_to0.75511517
37MP0001800_abnormal_humoral_immune0.74821385
38MP0002160_abnormal_reproductive_system0.74599977
39MP0002405_respiratory_system_inflammati0.74284304
40MP0002909_abnormal_adrenal_gland0.70704291
41MP0003866_abnormal_defecation0.67445810
42MP0005423_abnormal_somatic_nervous0.66283478
43MP0001790_abnormal_immune_system0.65797776
44MP0005387_immune_system_phenotype0.65797776
45MP0002136_abnormal_kidney_physiology0.64975143
46MP0005253_abnormal_eye_physiology0.64656413
47MP0000609_abnormal_liver_physiology0.64383937
48MP0002254_reproductive_system_inflammat0.64163261
49MP0008469_abnormal_protein_level0.63005939
50MP0004019_abnormal_vitamin_homeostasis0.59853595
51MP0000703_abnormal_thymus_morphology0.58785612
52MP0002693_abnormal_pancreas_physiology0.57841434
53MP0008875_abnormal_xenobiotic_pharmacok0.57518704
54MP0003315_abnormal_perineum_morphology0.57201772
55MP0000678_abnormal_parathyroid_gland0.56923291
56MP0002098_abnormal_vibrissa_morphology0.55040858
57MP0005389_reproductive_system_phenotype0.54016781
58MP0003880_abnormal_central_pattern0.53436692
59MP0001533_abnormal_skeleton_physiology0.52705001
60MP0002139_abnormal_hepatobiliary_system0.52568092
61MP0001835_abnormal_antigen_presentation0.51495945
62MP0003953_abnormal_hormone_level0.51461676
63MP0004947_skin_inflammation0.51050477
64MP0005551_abnormal_eye_electrophysiolog0.50133913
65MP0000462_abnormal_digestive_system0.49684486
66MP0002078_abnormal_glucose_homeostasis0.46997900
67MP0003121_genomic_imprinting0.46929985
68MP0001915_intracranial_hemorrhage0.45749409
69MP0000631_abnormal_neuroendocrine_gland0.45573482
70MP0003195_calcinosis0.45159836
71MP0008995_early_reproductive_senescence0.41657768
72MP0002722_abnormal_immune_system0.41456051
73MP0009642_abnormal_blood_homeostasis0.40552001
74MP0006292_abnormal_olfactory_placode0.39025722
75MP0002735_abnormal_chemical_nociception0.38585567
76MP0002998_abnormal_bone_remodeling0.38346485
77MP0001845_abnormal_inflammatory_respons0.38017697
78MP0000049_abnormal_middle_ear0.37328822
79MP0005503_abnormal_tendon_morphology0.37303405
80MP0004197_abnormal_fetal_growth/weight/0.36869809
81MP0008932_abnormal_embryonic_tissue0.36404711
82MP0001851_eye_inflammation0.36198067
83MP0001986_abnormal_taste_sensitivity0.35992057
84MP0004484_altered_response_of0.35493136
85MP0005334_abnormal_fat_pad0.35474180
86MP0002736_abnormal_nociception_after0.33188202
87MP0000598_abnormal_liver_morphology0.32124272
88MP0000477_abnormal_intestine_morphology0.32065974
89MP0005085_abnormal_gallbladder_physiolo0.31850186
90MP0009703_decreased_birth_body0.31849867
91MP0002429_abnormal_blood_cell0.31741328
92MP0005390_skeleton_phenotype0.31090636
93MP0009053_abnormal_anal_canal0.29103519
94MP0002452_abnormal_antigen_presenting0.28123324
95MP0009931_abnormal_skin_appearance0.27958663
96MP0002882_abnormal_neuron_morphology0.27395422
97MP0002419_abnormal_innate_immunity0.27116838
98MP0001501_abnormal_sleep_pattern0.26487926
99MP0002396_abnormal_hematopoietic_system0.26078897
100MP0000163_abnormal_cartilage_morphology0.25625295

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.18072082
2Abnormality of dental color (HP:0011073)7.84469081
3Abnormality of renal resorption (HP:0011038)7.48942857
4Osteomalacia (HP:0002749)7.28749418
5Polyuria (HP:0000103)7.12489035
6Abnormality of the dental pulp (HP:0006479)7.06106040
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.14402295
8Abnormal urine output (HP:0012590)6.08074518
9Abnormality of renal excretion (HP:0011036)5.30617977
10Round ear (HP:0100830)4.95126662
11Chronic bronchitis (HP:0004469)4.68397926
12Lip pit (HP:0100267)4.04663256
13Volvulus (HP:0002580)4.03313778
14Sparse lateral eyebrow (HP:0005338)3.98028188
15Molar tooth sign on MRI (HP:0002419)3.67379894
16Abnormality of midbrain morphology (HP:0002418)3.67379894
17Toxemia of pregnancy (HP:0100603)3.63238128
18IgM deficiency (HP:0002850)3.61405906
19Esophageal varix (HP:0002040)3.57816963
20Autoimmune thrombocytopenia (HP:0001973)3.57574817
21Nephrocalcinosis (HP:0000121)3.48686308
22Panhypogammaglobulinemia (HP:0003139)3.32607837
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.13270136
24Large earlobe (HP:0009748)3.11160720
25Lipoatrophy (HP:0100578)3.09425870
26Hypoparathyroidism (HP:0000829)3.05175709
27Abnormal respiratory motile cilium physiology (HP:0012261)3.00870354
28Rhinitis (HP:0012384)2.98742015
29Depressed nasal tip (HP:0000437)2.91053577
30Intestinal fistula (HP:0100819)2.89861047
31Drooling (HP:0002307)2.84150133
32Tachypnea (HP:0002789)2.83104056
33Ectopic kidney (HP:0000086)2.79937127
34Abnormality of transition element cation homeostasis (HP:0011030)2.76566190
35Excessive salivation (HP:0003781)2.69456274
36Hyperphosphaturia (HP:0003109)2.63370183
37Nephronophthisis (HP:0000090)2.58875043
38Petechiae (HP:0000967)2.58867212
39Ureteral stenosis (HP:0000071)2.57215002
40Small hand (HP:0200055)2.48239817
41Thick eyebrow (HP:0000574)2.46604756
42Preauricular pit (HP:0004467)2.39507400
43Periauricular skin pits (HP:0100277)2.39507400
44Ureteral obstruction (HP:0006000)2.35124509
45Short 5th finger (HP:0009237)2.28682257
46Glycosuria (HP:0003076)2.21748723
47Abnormality of urine glucose concentration (HP:0011016)2.21748723
48Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.21021508
49Personality changes (HP:0000751)2.20759266
50Abnormal urine phosphate concentration (HP:0012599)2.17601232
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17162585
52Gingival overgrowth (HP:0000212)2.14749190
53Hepatitis (HP:0012115)2.14533798
54Bronchitis (HP:0012387)2.12932507
55Anal stenosis (HP:0002025)2.11067939
56Nephropathy (HP:0000112)2.09550325
57Dilated cardiomyopathy (HP:0001644)2.07908342
58Abnormality of the fingertips (HP:0001211)2.05942889
59Inability to walk (HP:0002540)2.05098249
60Overgrowth (HP:0001548)11.2176600
61Amelogenesis imperfecta (HP:0000705)11.1386528
62Chronic mucocutaneous candidiasis (HP:0002728)1.98186219
63Recurrent cutaneous fungal infections (HP:0011370)1.98186219
64Striae distensae (HP:0001065)1.98166422
65Abnormality of the renal medulla (HP:0100957)1.95800769
66Agammaglobulinemia (HP:0004432)1.93097795
67Delayed eruption of teeth (HP:0000684)1.92952354
68Hypercalciuria (HP:0002150)1.89715313
69Decreased muscle mass (HP:0003199)1.88782800
70Preauricular skin tag (HP:0000384)1.87587765
71Chorioretinal coloboma (HP:0000567)1.87476594
72Sudden cardiac death (HP:0001645)1.85571137
73Anomalous pulmonary venous return (HP:0010772)1.85088970
74Recurrent otitis media (HP:0000403)1.79020073
75Decreased central vision (HP:0007663)1.75341859
76Alveolar cell carcinoma (HP:0006519)1.74017589
77Stage 5 chronic kidney disease (HP:0003774)1.73616964
78Abnormality of the pulmonary veins (HP:0011718)1.72846646
79Abnormality of salivation (HP:0100755)1.70797886
80Pendular nystagmus (HP:0012043)1.68294926
81Skin pits (HP:0100276)1.65930419
82Skin tags (HP:0010609)1.63810868
83Villous atrophy (HP:0011473)1.63653572
84Abnormality of small intestinal villus morphology (HP:0011472)1.63653572
85Colitis (HP:0002583)1.60860656
86Neoplasm of the tracheobronchial system (HP:0100552)1.58352573
87Truncal ataxia (HP:0002078)1.56583565
88Limited elbow extension (HP:0001377)1.56129390
89Blepharitis (HP:0000498)1.53965743
90Renal tubular dysfunction (HP:0000124)1.53155730
91Prominent supraorbital ridges (HP:0000336)1.51065159
92Palmoplantar keratoderma (HP:0000982)1.47409580
93Chondrocalcinosis (HP:0000934)1.46856812
94Lymphangioma (HP:0100764)1.45006693
95Broad nasal tip (HP:0000455)1.44785777
96Ectropion (HP:0000656)1.44552292
97Abnormality of Sharpey fibers (HP:0100685)1.44538723
98Abnormal rod and cone electroretinograms (HP:0008323)1.44504235
99Polyneuropathy (HP:0001271)1.41990082
100Short palm (HP:0004279)1.38589624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.16794374
2BLK4.71903307
3STK34.10337813
4RIPK42.89146488
5BMPR22.06242714
6NTRK213.4443751
7CDC42BPA1.97452190
8TLK11.61875863
9ZAK1.34220170
10HIPK21.31786862
11FGFR11.13861829
12GRK11.07002982
13TAF10.90267821
14INSRR0.77512806
15ADRBK20.73411512
16SYK0.70364459
17ROCK20.69634375
18PRKAA10.65720899
19GRK70.63129102
20MAP4K20.62200686
21OBSCN0.61089846
22ROCK10.60865428
23PRKCQ0.59854219
24MUSK0.54501624
25MATK0.53562524
26TXK0.53490841
27STK38L0.50741252
28SRC0.50140832
29PRKCI0.49083724
30WNK30.48884820
31VRK10.48857217
32ABL10.47665458
33MAP3K30.45783407
34ERBB40.44836277
35TEC0.43432509
36TIE10.41995140
37PRKACG0.41311027
38MAPK150.40166150
39PRKACA0.39266171
40STK240.38457771
41CAMK2A0.37514529
42ITK0.36119264
43MAP3K50.36051526
44DDR20.33525027
45PLK10.32105824
46SRPK10.31849448
47PRKACB0.30182113
48GRK50.26193639
49EPHA20.25805082
50CHUK0.25775938
51PIK3CG0.25707779
52MAP2K60.25685370
53FRK0.25654071
54AKT30.24824316
55GRK60.24767404
56LYN0.23899399
57PKN10.23855148
58KIT0.23846862
59GSK3B0.23282798
60PRKCA0.22707080
61CAMK40.22524092
62WNK40.21990994
63ADRBK10.21300920
64PHKG20.20736690
65PHKG10.20736690
66RPS6KA30.20389176
67MAPK140.20331464
68ERBB20.19444011
69MAP2K70.19434206
70PRKCB0.19308803
71PIK3CA0.18547001
72IKBKB0.18231577
73EPHA40.17147871
74OXSR10.16920339
75PRKCD0.16599524
76CSNK1A10.16272999
77TGFBR20.15753500
78RPS6KA50.15661466
79MST1R0.15233872
80MAP3K90.15169777
81PLK40.14339074
82PRKCG0.13293817
83LMTK20.13109146
84FYN0.12511943
85IGF1R0.12493889
86PIM10.11626015
87DAPK30.11426573
88BMPR1B0.11148698
89CDK10.10889281
90STK390.10481536
91MAPK90.10005901
92PRKDC0.09753778
93CSF1R0.09729864
94PRKCE0.09001743
95AURKA0.08751427
96CAMK2B0.08575044
97ABL20.08399173
98AKT10.08344504
99CAMK2G0.08153167
100JAK30.08105999

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.21120635
2Sulfur metabolism_Homo sapiens_hsa009203.86200633
3Sulfur relay system_Homo sapiens_hsa041223.55388353
4Ovarian steroidogenesis_Homo sapiens_hsa049133.32934559
5Linoleic acid metabolism_Homo sapiens_hsa005913.00925217
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98783167
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.83525490
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.74907082
9Bile secretion_Homo sapiens_hsa049762.30797991
10Collecting duct acid secretion_Homo sapiens_hsa049662.29156857
11Salivary secretion_Homo sapiens_hsa049702.10967826
12Thyroid hormone synthesis_Homo sapiens_hsa049182.10451232
13Vibrio cholerae infection_Homo sapiens_hsa051102.08633842
14Pancreatic secretion_Homo sapiens_hsa049722.07238997
15Fat digestion and absorption_Homo sapiens_hsa049752.06133385
16Gastric acid secretion_Homo sapiens_hsa049712.01588583
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92287190
18Synaptic vesicle cycle_Homo sapiens_hsa047211.82465104
19Taste transduction_Homo sapiens_hsa047421.82215116
20Circadian entrainment_Homo sapiens_hsa047131.81852621
21Cocaine addiction_Homo sapiens_hsa050301.79354765
22Insulin secretion_Homo sapiens_hsa049111.77481736
23Morphine addiction_Homo sapiens_hsa050321.72898903
24GABAergic synapse_Homo sapiens_hsa047271.72004032
25Glutamatergic synapse_Homo sapiens_hsa047241.71902029
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.71712266
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68923567
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.63460868
29Dilated cardiomyopathy_Homo sapiens_hsa054141.54523919
30Ether lipid metabolism_Homo sapiens_hsa005651.52845310
31Gap junction_Homo sapiens_hsa045401.47643270
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47350421
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40568294
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38867740
35Amphetamine addiction_Homo sapiens_hsa050311.30842887
36Arachidonic acid metabolism_Homo sapiens_hsa005901.30783405
37Melanogenesis_Homo sapiens_hsa049161.28403756
38GnRH signaling pathway_Homo sapiens_hsa049121.27487714
39Systemic lupus erythematosus_Homo sapiens_hsa053221.27455743
40Cholinergic synapse_Homo sapiens_hsa047251.15519404
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15311808
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13770222
43Alcoholism_Homo sapiens_hsa050341.11596787
44Oxytocin signaling pathway_Homo sapiens_hsa049211.09424314
45Platelet activation_Homo sapiens_hsa046111.09383350
46Dorso-ventral axis formation_Homo sapiens_hsa043201.03691616
47Calcium signaling pathway_Homo sapiens_hsa040201.03218902
48Estrogen signaling pathway_Homo sapiens_hsa049151.01464777
49Circadian rhythm_Homo sapiens_hsa047100.96376827
50Serotonergic synapse_Homo sapiens_hsa047260.79912772
51Oocyte meiosis_Homo sapiens_hsa041140.72010751
52Rheumatoid arthritis_Homo sapiens_hsa053230.68801157
53Chemokine signaling pathway_Homo sapiens_hsa040620.66060027
54Pyruvate metabolism_Homo sapiens_hsa006200.61962497
55ECM-receptor interaction_Homo sapiens_hsa045120.61763336
56Hedgehog signaling pathway_Homo sapiens_hsa043400.60250465
57RNA degradation_Homo sapiens_hsa030180.57794194
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56836461
59cAMP signaling pathway_Homo sapiens_hsa040240.52487515
60Primary immunodeficiency_Homo sapiens_hsa053400.50262770
61Asthma_Homo sapiens_hsa053100.47582785
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.40627059
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40441467
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.38471154
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.35970529
66Type I diabetes mellitus_Homo sapiens_hsa049400.34845638
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33943257
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32862978
69Staphylococcus aureus infection_Homo sapiens_hsa051500.32420384
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31890059
71Parkinsons disease_Homo sapiens_hsa050120.30413233
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.30252748
73Retinol metabolism_Homo sapiens_hsa008300.29722601
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.28788565
75Dopaminergic synapse_Homo sapiens_hsa047280.28381376
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26969127
77Viral carcinogenesis_Homo sapiens_hsa052030.26964317
78Purine metabolism_Homo sapiens_hsa002300.26947890
79Caffeine metabolism_Homo sapiens_hsa002320.26376894
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.24578320
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24300729
82Allograft rejection_Homo sapiens_hsa053300.24271779
83Rap1 signaling pathway_Homo sapiens_hsa040150.22501025
84Autoimmune thyroid disease_Homo sapiens_hsa053200.21458037
85Nicotine addiction_Homo sapiens_hsa050330.20744140
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.20635406
87HTLV-I infection_Homo sapiens_hsa051660.18611586
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.18489978
89Chemical carcinogenesis_Homo sapiens_hsa052040.17162196
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15852113
91Ras signaling pathway_Homo sapiens_hsa040140.15405295
92Hematopoietic cell lineage_Homo sapiens_hsa046400.14697091
93Graft-versus-host disease_Homo sapiens_hsa053320.13784595
94Oxidative phosphorylation_Homo sapiens_hsa001900.13369463
95African trypanosomiasis_Homo sapiens_hsa051430.10843265
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10256989
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.10230389
98Renin secretion_Homo sapiens_hsa049240.07047304
99Leishmaniasis_Homo sapiens_hsa051400.06834888
100Tuberculosis_Homo sapiens_hsa051520.06280441

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