NPM1P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)9.88994468
2regulation of T-helper 1 cell differentiation (GO:0045625)9.56840369
3seminiferous tubule development (GO:0072520)9.33314652
4negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.91273841
5regulation of T-helper 2 cell differentiation (GO:0045628)8.86598347
6positive regulation of RNA splicing (GO:0033120)8.83873687
7negative regulation of type 2 immune response (GO:0002829)8.59495743
8activation of protein kinase A activity (GO:0034199)8.50673521
9negative regulation of alpha-beta T cell differentiation (GO:0046639)8.17134580
10detection of chemical stimulus involved in sensory perception (GO:0050907)8.09389789
11enteric nervous system development (GO:0048484)7.39712417
12positive regulation of mitochondrial fission (GO:0090141)7.23020746
13cAMP biosynthetic process (GO:0006171)7.19058675
14regulation of protein sumoylation (GO:0033233)6.53024389
15positive regulation of T-helper 1 type immune response (GO:0002827)6.51210695
16synaptic transmission, dopaminergic (GO:0001963)6.44935959
17righting reflex (GO:0060013)6.27656148
18dendritic spine morphogenesis (GO:0060997)6.24757261
19positive regulation of T-helper cell differentiation (GO:0045624)5.94052814
20detection of chemical stimulus (GO:0009593)5.77238284
21hepatocyte apoptotic process (GO:0097284)5.76912158
22phosphatidylinositol acyl-chain remodeling (GO:0036149)5.54415129
23arachidonic acid secretion (GO:0050482)5.48157075
24icosanoid secretion (GO:0032309)5.48157075
25neural tube formation (GO:0001841)5.46841409
26heterotypic cell-cell adhesion (GO:0034113)5.39110874
27phosphatidylserine acyl-chain remodeling (GO:0036150)5.35964209
28regulation of mitochondrial fission (GO:0090140)5.16645669
29endothelial cell differentiation (GO:0045446)4.98813588
30phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.85047823
31negative regulation of alpha-beta T cell activation (GO:0046636)4.80538062
32drug transmembrane transport (GO:0006855)4.80416117
33attachment of spindle microtubules to kinetochore (GO:0008608)4.76084719
34regulation of T-helper 1 type immune response (GO:0002825)4.68642320
35regulation of T-helper cell differentiation (GO:0045622)4.63516359
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.56189548
37icosanoid transport (GO:0071715)4.45154379
38fatty acid derivative transport (GO:1901571)4.45154379
39chemosensory behavior (GO:0007635)4.41372125
40energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.39495299
41ATP hydrolysis coupled proton transport (GO:0015991)4.39495299
42cilium or flagellum-dependent cell motility (GO:0001539)4.33201459
43embryonic digestive tract morphogenesis (GO:0048557)4.31865053
44neuronal ion channel clustering (GO:0045161)4.20969202
45positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.10362864
46vocalization behavior (GO:0071625)4.07707337
47retina layer formation (GO:0010842)4.02456759
48regulation of cAMP-mediated signaling (GO:0043949)3.99003113
49neurofilament cytoskeleton organization (GO:0060052)3.95979338
50nephron tubule morphogenesis (GO:0072078)3.92981593
51nephron epithelium morphogenesis (GO:0072088)3.92981593
52phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.91604469
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.88818514
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.86882598
55protein localization to synapse (GO:0035418)3.84298514
56hyaluronan catabolic process (GO:0030214)3.75905696
57positive regulation of membrane potential (GO:0045838)3.70719920
58monoamine transport (GO:0015844)3.66999389
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66943036
60regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.66590254
61negative regulation of T cell differentiation (GO:0045581)3.62976943
62leukotriene biosynthetic process (GO:0019370)3.59297504
63response to dietary excess (GO:0002021)3.55488555
64water transport (GO:0006833)3.53684056
65left/right axis specification (GO:0070986)3.52968003
66cellular response to ATP (GO:0071318)3.51705336
67dendritic spine organization (GO:0097061)3.49988629
68cAMP metabolic process (GO:0046058)3.49878248
69phosphatidylcholine acyl-chain remodeling (GO:0036151)3.48184744
70neuromuscular process controlling posture (GO:0050884)3.48056267
71regulation of type 2 immune response (GO:0002828)3.47671021
72cyclic purine nucleotide metabolic process (GO:0052652)3.46627820
73cyclic nucleotide biosynthetic process (GO:0009190)3.40946324
74cellular response to glucagon stimulus (GO:0071377)3.39129315
75negative regulation of actin filament bundle assembly (GO:0032232)3.35119066
76mitochondrial fusion (GO:0008053)3.34623909
77reflex (GO:0060004)3.34448056
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.25803008
79positive regulation of protein targeting to membrane (GO:0090314)3.24128985
80positive regulation of alpha-beta T cell differentiation (GO:0046638)3.21618477
81fluid transport (GO:0042044)3.20216227
82drug transport (GO:0015893)3.18346472
83negative regulation of astrocyte differentiation (GO:0048712)3.17642681
84detection of light stimulus involved in sensory perception (GO:0050962)3.15498850
85detection of light stimulus involved in visual perception (GO:0050908)3.15498850
86positive regulation of steroid hormone secretion (GO:2000833)3.08760653
87response to auditory stimulus (GO:0010996)3.08164900
88positive regulation of dendritic spine development (GO:0060999)3.07730524
89sulfur amino acid catabolic process (GO:0000098)3.07657954
90phosphatidylserine metabolic process (GO:0006658)3.05188442
91positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.01994724
92male meiosis (GO:0007140)2.99025966
93renal tubule morphogenesis (GO:0061333)2.98284473
94chaperone-mediated protein transport (GO:0072321)2.95063294
95adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.92032644
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)12.6528575
97tooth mineralization (GO:0034505)12.5438098
98negative regulation of T-helper cell differentiation (GO:0045623)10.9687530
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.9687530
100positive regulation of protein sumoylation (GO:0033235)10.2791619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.66908189
2IGF1R_20145208_ChIP-Seq_DFB_Human5.29907755
3VDR_22108803_ChIP-Seq_LS180_Human5.09156417
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.39347520
5AR_21572438_ChIP-Seq_LNCaP_Human4.16429401
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.77998253
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27360393
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26751233
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.23217345
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14213049
11ZNF274_21170338_ChIP-Seq_K562_Hela2.04473425
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04323802
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.04323802
14GBX2_23144817_ChIP-Seq_PC3_Human2.01348290
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98883453
16TP53_16413492_ChIP-PET_HCT116_Human1.96212923
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87571388
18ER_23166858_ChIP-Seq_MCF-7_Human1.69050494
19EZH2_22144423_ChIP-Seq_EOC_Human1.68586723
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67559957
21RNF2_27304074_Chip-Seq_NSC_Mouse1.65295630
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.64751679
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61476482
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60418008
25YY1_22570637_ChIP-Seq_MALME-3M_Human1.60103909
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.59831871
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55814979
28EGR1_19032775_ChIP-ChIP_M12_Human1.53938386
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48011876
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47004384
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42169200
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37469215
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34929398
34CBP_20019798_ChIP-Seq_JUKART_Human1.34929398
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.34624358
36FUS_26573619_Chip-Seq_HEK293_Human1.32906935
37BCAT_22108803_ChIP-Seq_LS180_Human1.32465952
38TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.30474006
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.30310394
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.29325938
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28993793
42STAT3_23295773_ChIP-Seq_U87_Human1.28878831
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28852521
44DROSHA_22980978_ChIP-Seq_HELA_Human1.28609373
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27469808
46RXR_22108803_ChIP-Seq_LS180_Human1.27015400
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.26628343
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.26249545
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25259922
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.24954538
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24413817
52SMAD3_21741376_ChIP-Seq_HESCs_Human1.22914624
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.21492815
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.21153389
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20757118
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20205921
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19621089
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.18723333
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17410232
60PHF8_20622853_ChIP-Seq_HELA_Human1.16977783
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16497740
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16405647
63SMAD4_21799915_ChIP-Seq_A2780_Human1.15393083
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12964273
65P300_19829295_ChIP-Seq_ESCs_Human1.11989909
66P53_22387025_ChIP-Seq_ESCs_Mouse1.11699073
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11642596
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10827664
69TBL1_22424771_ChIP-Seq_293T_Human1.10700763
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.09101631
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.08963146
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08422620
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07545859
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.07278509
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06661828
76TCF4_22108803_ChIP-Seq_LS180_Human1.05804534
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05414063
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05231105
79AR_25329375_ChIP-Seq_VCAP_Human1.04602705
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.04597351
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.01589823
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01175348
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01120597
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00987941
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00779081
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.00779081
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.00418516
88SOX2_19829295_ChIP-Seq_ESCs_Human0.97982100
89NANOG_19829295_ChIP-Seq_ESCs_Human0.97982100
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.97332385
91REST_21632747_ChIP-Seq_MESCs_Mouse0.96189296
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94266814
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93920667
94ETV1_20927104_ChIP-Seq_GIST48_Human0.93659963
95NFYB_21822215_ChIP-Seq_K562_Human0.93410617
96EWS_26573619_Chip-Seq_HEK293_Human0.93100780
97HTT_18923047_ChIP-ChIP_STHdh_Human0.91674953
98GATA1_19941826_ChIP-Seq_K562_Human0.90839656
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.90619329
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89674425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism8.41462654
2MP0004130_abnormal_muscle_cell3.95975516
3MP0003252_abnormal_bile_duct3.59624632
4MP0004264_abnormal_extraembryonic_tissu3.28778893
5MP0004133_heterotaxia3.19602728
6MP0006072_abnormal_retinal_apoptosis3.12182466
7MP0002751_abnormal_autonomic_nervous2.65367231
8MP0002928_abnormal_bile_duct2.25288431
9MP0005646_abnormal_pituitary_gland2.07285640
10MP0005448_abnormal_energy_balance2.06186678
11MP0005408_hypopigmentation2.02695584
12MP0001529_abnormal_vocalization2.00749302
13MP0005084_abnormal_gallbladder_morpholo11.3761814
14MP0002102_abnormal_ear_morphology1.99577390
15MP0001270_distended_abdomen1.82490478
16MP0003943_abnormal_hepatobiliary_system1.81547608
17MP0005379_endocrine/exocrine_gland_phen1.49917685
18MP0009764_decreased_sensitivity_to1.48962340
19MP0005220_abnormal_exocrine_pancreas1.46847496
20MP0008875_abnormal_xenobiotic_pharmacok1.38999588
21MP0003718_maternal_effect1.36242692
22MP0003329_amyloid_beta_deposits1.34108413
23MP0003121_genomic_imprinting1.28230133
24MP0005253_abnormal_eye_physiology1.23429840
25MP0000604_amyloidosis1.17522056
26MP0002572_abnormal_emotion/affect_behav1.14593410
27MP0005165_increased_susceptibility_to1.13983854
28MP0004272_abnormal_basement_membrane1.13108359
29MP0000372_irregular_coat_pigmentation1.06741927
30MP0003195_calcinosis1.02859265
31MP0005551_abnormal_eye_electrophysiolog1.02598158
32MP0001905_abnormal_dopamine_level1.00230658
33MP0001835_abnormal_antigen_presentation0.98594821
34MP0008995_early_reproductive_senescence0.94031792
35MP0001800_abnormal_humoral_immune0.93524698
36MP0002909_abnormal_adrenal_gland0.87369391
37MP0000470_abnormal_stomach_morphology0.87260290
38MP0000465_gastrointestinal_hemorrhage0.85479103
39MP0006276_abnormal_autonomic_nervous0.80954576
40MP0004142_abnormal_muscle_tone0.80755023
41MP0008469_abnormal_protein_level0.79708289
42MP0008569_lethality_at_weaning0.78593935
43MP0001944_abnormal_pancreas_morphology0.76845980
44MP0002693_abnormal_pancreas_physiology0.76811615
45MP0003866_abnormal_defecation0.72803962
46MP0001790_abnormal_immune_system0.72506108
47MP0005387_immune_system_phenotype0.72506108
48MP0000371_diluted_coat_color0.72491785
49MP0003638_abnormal_response/metabolism_0.67901640
50MP0005645_abnormal_hypothalamus_physiol0.65790838
51MP0009697_abnormal_copulation0.65279583
52MP0002405_respiratory_system_inflammati0.65138394
53MP0003787_abnormal_imprinting0.64440882
54MP0001501_abnormal_sleep_pattern0.64382567
55MP0002822_catalepsy0.62428904
56MP0000639_abnormal_adrenal_gland0.61489912
57MP0002098_abnormal_vibrissa_morphology0.61434954
58MP0000631_abnormal_neuroendocrine_gland0.61360225
59MP0004019_abnormal_vitamin_homeostasis0.61087511
60MP0003011_delayed_dark_adaptation0.61025750
61MP0001958_emphysema0.58549348
62MP0003283_abnormal_digestive_organ0.57299329
63MP0006082_CNS_inflammation0.57193608
64MP0003953_abnormal_hormone_level0.57098810
65MP0008872_abnormal_physiological_respon0.55826269
66MP0002229_neurodegeneration0.55791175
67MP0008877_abnormal_DNA_methylation0.54436519
68MP0000609_abnormal_liver_physiology0.53999237
69MP0002735_abnormal_chemical_nociception0.53715289
70MP0008789_abnormal_olfactory_epithelium0.51807949
71MP0006292_abnormal_olfactory_placode0.51120885
72MP0002876_abnormal_thyroid_physiology0.50768659
73MP0000703_abnormal_thymus_morphology0.49832662
74MP0002136_abnormal_kidney_physiology0.49771128
75MP0002736_abnormal_nociception_after0.48281043
76MP0001845_abnormal_inflammatory_respons0.48248452
77MP0002078_abnormal_glucose_homeostasis0.48218019
78MP0002277_abnormal_respiratory_mucosa0.47860589
79MP0005410_abnormal_fertilization0.47722858
80MP0005671_abnormal_response_to0.44961885
81MP0002882_abnormal_neuron_morphology0.43579198
82MP0009642_abnormal_blood_homeostasis0.43316157
83MP0005164_abnormal_response_to0.41729604
84MP0004885_abnormal_endolymph0.41047141
85MP0005195_abnormal_posterior_eye0.40804490
86MP0004782_abnormal_surfactant_physiolog0.39527795
87MP0005647_abnormal_sex_gland0.39438911
88MP0005360_urolithiasis0.38870946
89MP0005499_abnormal_olfactory_system0.38802183
90MP0005394_taste/olfaction_phenotype0.38802183
91MP0005391_vision/eye_phenotype0.38134347
92MP0002452_abnormal_antigen_presenting0.38061705
93MP0002429_abnormal_blood_cell0.37839447
94MP0003698_abnormal_male_reproductive0.37658912
95MP0000049_abnormal_middle_ear0.37122289
96MP0002723_abnormal_immune_serum0.37030216
97MP0003567_abnormal_fetal_cardiomyocyte0.36921261
98MP0003878_abnormal_ear_physiology0.36921210
99MP0005377_hearing/vestibular/ear_phenot0.36921210
100MP0008058_abnormal_DNA_repair0.36605525

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)9.46846589
2Overgrowth (HP:0001548)8.94249340
3Abnormality of calcium-phosphate metabolism (HP:0100530)8.17944072
4Abnormality of renal resorption (HP:0011038)7.36739509
5Abnormality of dental color (HP:0011073)7.18346894
6Polyuria (HP:0000103)6.88570309
7Osteomalacia (HP:0002749)6.37936344
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.89544236
9Abnormality of the dental pulp (HP:0006479)5.86455876
10Abnormal urine output (HP:0012590)5.82059527
11Abnormality of renal excretion (HP:0011036)5.05006071
12Volvulus (HP:0002580)4.68636693
13Abnormality of midbrain morphology (HP:0002418)4.48266953
14Molar tooth sign on MRI (HP:0002419)4.48266953
15Chronic bronchitis (HP:0004469)4.06911862
16Nephronophthisis (HP:0000090)3.71042279
17Round ear (HP:0100830)3.55505301
18Drooling (HP:0002307)3.53543116
19Abnormal respiratory motile cilium physiology (HP:0012261)3.46603142
20Excessive salivation (HP:0003781)3.31801100
21Autoimmune thrombocytopenia (HP:0001973)3.30181536
22Rhinitis (HP:0012384)3.21967387
23Hyperphosphaturia (HP:0003109)3.21903912
24Panhypogammaglobulinemia (HP:0003139)3.19157534
25Nephrocalcinosis (HP:0000121)3.17833958
26IgM deficiency (HP:0002850)3.08369928
27Recurrent cutaneous fungal infections (HP:0011370)3.06005739
28Chronic mucocutaneous candidiasis (HP:0002728)3.06005739
29Toxemia of pregnancy (HP:0100603)2.98509474
30Inability to walk (HP:0002540)2.94917073
31Lip pit (HP:0100267)2.90020622
32Tachypnea (HP:0002789)2.88834172
33Abnormality of the renal medulla (HP:0100957)2.88208136
34Glycosuria (HP:0003076)2.69866487
35Abnormality of urine glucose concentration (HP:0011016)2.69866487
36Esophageal varix (HP:0002040)2.64578991
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.55803108
38Abnormal urine phosphate concentration (HP:0012599)2.55215988
39Depressed nasal tip (HP:0000437)2.54930655
40Intestinal fistula (HP:0100819)2.46557950
41Large earlobe (HP:0009748)2.36286157
42Hypoparathyroidism (HP:0000829)2.34454835
43Lipoatrophy (HP:0100578)2.24627157
44Abnormality of salivation (HP:0100755)2.21797083
45Sparse lateral eyebrow (HP:0005338)2.21077045
46Thyroid-stimulating hormone excess (HP:0002925)2.13200054
47Thick eyebrow (HP:0000574)2.13089831
48Ureteral stenosis (HP:0000071)2.11170008
49Ureteral obstruction (HP:0006000)2.10414327
50Decreased muscle mass (HP:0003199)2.04199416
51Ectopic kidney (HP:0000086)2.01868357
52Hepatitis (HP:0012115)2.01075752
53Chorioretinal coloboma (HP:0000567)1.93602760
54Nephropathy (HP:0000112)1.92236951
55Oculomotor apraxia (HP:0000657)1.90881989
56Small hand (HP:0200055)1.87930061
57Decreased central vision (HP:0007663)1.85647337
58Hypercalciuria (HP:0002150)1.83751587
59Striae distensae (HP:0001065)1.79899949
60Stomatitis (HP:0010280)1.78166531
61Bronchitis (HP:0012387)1.76907627
62Agammaglobulinemia (HP:0004432)1.75662952
63Bronchiectasis (HP:0002110)1.74111373
64Personality changes (HP:0000751)1.73853697
65Aplasia/hypoplasia of the uterus (HP:0008684)1.72475227
66Renal tubular dysfunction (HP:0000124)1.72127340
67Congenital stationary night blindness (HP:0007642)1.71716153
68Abnormality of transition element cation homeostasis (HP:0011030)1.70689269
69Hypoplasia of the uterus (HP:0000013)1.69054505
70Dilated cardiomyopathy (HP:0001644)1.61543719
71Gingival overgrowth (HP:0000212)1.59736003
72Amyotrophic lateral sclerosis (HP:0007354)1.58175664
73Stage 5 chronic kidney disease (HP:0003774)1.57906921
74True hermaphroditism (HP:0010459)1.55287940
75Recurrent otitis media (HP:0000403)1.54090208
76Highly arched eyebrow (HP:0002553)1.53167914
77Abnormality of T cell physiology (HP:0011840)1.51808105
78Petechiae (HP:0000967)1.49923418
79Polyneuropathy (HP:0001271)1.49444049
80Truncal ataxia (HP:0002078)1.47642293
81Abnormality of the fingertips (HP:0001211)1.46629149
82Preauricular skin tag (HP:0000384)1.44234540
83Abnormality of the renal collecting system (HP:0004742)1.42515633
84Abnormality of macular pigmentation (HP:0008002)1.41878856
85Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.40059943
86Growth hormone deficiency (HP:0000824)1.38517648
87Short 5th finger (HP:0009237)1.37748338
88Encephalitis (HP:0002383)1.37237282
89Adactyly (HP:0009776)1.36961860
90Medial flaring of the eyebrow (HP:0010747)1.35791688
91Abnormal respiratory epithelium morphology (HP:0012253)1.35331834
92Abnormal respiratory motile cilium morphology (HP:0005938)1.35331834
93Sudden cardiac death (HP:0001645)1.34931168
94Male pseudohermaphroditism (HP:0000037)1.33376898
95Oligodactyly (hands) (HP:0001180)1.33316051
96Delayed eruption of teeth (HP:0000684)1.32942055
97Widely spaced teeth (HP:0000687)1.32932449
98Abolished electroretinogram (ERG) (HP:0000550)1.31982615
99Constricted visual fields (HP:0001133)1.31691846
100Decreased testicular size (HP:0008734)1.31614356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.58313803
2STK33.62231368
3BLK3.24273100
4ZAK2.50763492
5MAP4K22.37664883
6TLK12.08273721
7NTRK211.7909304
8RIPK41.86323921
9BMPR21.63232344
10SRPK11.44699684
11ADRBK21.24426797
12PINK11.23438810
13WNK31.21225937
14CDC42BPA1.19785909
15PBK1.13874470
16INSRR1.12399343
17TRIM281.08338598
18VRK11.02960080
19TNK20.95694525
20MST40.93884072
21NUAK10.87647448
22KIT0.83841956
23GRK70.82762725
24GRK10.79357913
25TAOK30.77830142
26FGFR10.76755709
27MAPK130.75883132
28FRK0.75801246
29BCR0.72296425
30PLK40.70742280
31EIF2AK30.70724774
32ACVR1B0.69783040
33TXK0.68646407
34HIPK20.67547435
35PRKCQ0.66169378
36SYK0.63874453
37MARK10.63311484
38TSSK60.61888322
39TEC0.60707407
40BMPR1B0.60065883
41CCNB10.59814900
42PLK10.59458113
43PLK30.59038404
44MATK0.58098426
45OBSCN0.56858951
46TNIK0.56350145
47PIK3CG0.56221375
48PKN10.55866861
49MKNK10.55105801
50PASK0.53488881
51WNK40.52869990
52ABL10.51375507
53STK390.50614135
54PRKCE0.50536073
55DAPK20.49770515
56WEE10.48192688
57CSNK1G20.48157876
58ROCK20.46966928
59TIE10.46169396
60CASK0.46030839
61PRKACA0.46025227
62CAMK2A0.45861287
63SRC0.45301547
64OXSR10.44932478
65PRKCG0.44688978
66PRKAA10.44629483
67CSNK1G30.44379731
68PRKACG0.42036151
69ERBB30.41742528
70MAP3K40.41188575
71BRSK20.41116321
72CSNK1G10.41031324
73PRKACB0.40565505
74BCKDK0.37913662
75MINK10.37698012
76MKNK20.36593842
77PRKG20.36238800
78MUSK0.35635958
79ROCK10.34477656
80DYRK20.34192457
81PRKCA0.33958622
82AKT30.32509069
83PAK30.32482670
84CSNK1A1L0.31617078
85NEK10.30941966
86CSNK1A10.30511658
87EPHA40.27873628
88MAP2K70.26932093
89FLT30.26557763
90PRKCB0.26332476
91PRKG10.24915942
92ADRBK10.24674947
93DYRK30.24543957
94ITK0.24496377
95PLK20.23434581
96RPS6KA50.22899535
97LATS10.22064518
98PHKG20.21838307
99PHKG10.21838307
100LYN0.21347051

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.24704084
2Sulfur relay system_Homo sapiens_hsa041223.59792371
3Sulfur metabolism_Homo sapiens_hsa009203.28865421
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26137718
5Linoleic acid metabolism_Homo sapiens_hsa005913.15601896
6Ovarian steroidogenesis_Homo sapiens_hsa049133.07461577
7Collecting duct acid secretion_Homo sapiens_hsa049662.72679632
8Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.25213996
9Taste transduction_Homo sapiens_hsa047422.14839397
10Fat digestion and absorption_Homo sapiens_hsa049752.08028839
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.05738215
12Vibrio cholerae infection_Homo sapiens_hsa051102.05525846
13Salivary secretion_Homo sapiens_hsa049701.95909748
14Pancreatic secretion_Homo sapiens_hsa049721.93758630
15Ether lipid metabolism_Homo sapiens_hsa005651.85869399
16Bile secretion_Homo sapiens_hsa049761.84052432
17Synaptic vesicle cycle_Homo sapiens_hsa047211.83510714
18Thyroid hormone synthesis_Homo sapiens_hsa049181.82549319
19Morphine addiction_Homo sapiens_hsa050321.77001997
20GABAergic synapse_Homo sapiens_hsa047271.74267801
21Cocaine addiction_Homo sapiens_hsa050301.68476946
22Glutamatergic synapse_Homo sapiens_hsa047241.67764066
23Gastric acid secretion_Homo sapiens_hsa049711.66660323
24Circadian entrainment_Homo sapiens_hsa047131.65359336
25Insulin secretion_Homo sapiens_hsa049111.55999068
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.47793568
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44402932
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43574841
29Asthma_Homo sapiens_hsa053101.39691418
30Arachidonic acid metabolism_Homo sapiens_hsa005901.34722498
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30253472
32Pyruvate metabolism_Homo sapiens_hsa006201.29540719
33Amphetamine addiction_Homo sapiens_hsa050311.26253560
34RNA degradation_Homo sapiens_hsa030181.25070529
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17398688
36Dilated cardiomyopathy_Homo sapiens_hsa054141.16592390
37Oxidative phosphorylation_Homo sapiens_hsa001901.14809303
38Gap junction_Homo sapiens_hsa045401.11646607
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11635790
40Parkinsons disease_Homo sapiens_hsa050121.07798099
41Allograft rejection_Homo sapiens_hsa053301.05021280
42Primary immunodeficiency_Homo sapiens_hsa053401.01942836
43Rheumatoid arthritis_Homo sapiens_hsa053230.98319208
44Autoimmune thyroid disease_Homo sapiens_hsa053200.95861235
45Oxytocin signaling pathway_Homo sapiens_hsa049210.94867747
46Circadian rhythm_Homo sapiens_hsa047100.94427554
47Cholinergic synapse_Homo sapiens_hsa047250.94211829
48Calcium signaling pathway_Homo sapiens_hsa040200.92671908
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90507782
50Serotonergic synapse_Homo sapiens_hsa047260.89734364
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.86213290
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83758444
53Melanogenesis_Homo sapiens_hsa049160.83353449
54Platelet activation_Homo sapiens_hsa046110.79257723
55Type I diabetes mellitus_Homo sapiens_hsa049400.75059809
56Oocyte meiosis_Homo sapiens_hsa041140.72446564
57GnRH signaling pathway_Homo sapiens_hsa049120.72422258
58Nicotine addiction_Homo sapiens_hsa050330.69169484
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.65944487
60Graft-versus-host disease_Homo sapiens_hsa053320.64465311
61Dorso-ventral axis formation_Homo sapiens_hsa043200.62053545
62Purine metabolism_Homo sapiens_hsa002300.61308597
63Estrogen signaling pathway_Homo sapiens_hsa049150.56011117
64RNA polymerase_Homo sapiens_hsa030200.54328586
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53805745
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.50882004
67Caffeine metabolism_Homo sapiens_hsa002320.50829867
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47334005
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43030244
70Chemokine signaling pathway_Homo sapiens_hsa040620.42298142
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41601571
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40838817
73Retinol metabolism_Homo sapiens_hsa008300.39260093
74Chemical carcinogenesis_Homo sapiens_hsa052040.38553065
75Nitrogen metabolism_Homo sapiens_hsa009100.37869443
76Protein export_Homo sapiens_hsa030600.37465460
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35400413
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35237055
79Hematopoietic cell lineage_Homo sapiens_hsa046400.33354999
80Phototransduction_Homo sapiens_hsa047440.33127728
81Dopaminergic synapse_Homo sapiens_hsa047280.31154070
82Proteasome_Homo sapiens_hsa030500.29588400
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28937217
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27415025
85Vitamin B6 metabolism_Homo sapiens_hsa007500.27149087
86Antigen processing and presentation_Homo sapiens_hsa046120.26855134
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25610111
88Alcoholism_Homo sapiens_hsa050340.23666259
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23510871
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.23473180
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23140842
92Staphylococcus aureus infection_Homo sapiens_hsa051500.22006098
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21493564
94Huntingtons disease_Homo sapiens_hsa050160.20940948
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19761882
96cAMP signaling pathway_Homo sapiens_hsa040240.19463830
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.18962854
98ECM-receptor interaction_Homo sapiens_hsa045120.18690533
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.18439596
100Systemic lupus erythematosus_Homo sapiens_hsa053220.18285595

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