NPM1P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.42795897
2cytidine metabolic process (GO:0046087)4.88297195
3cytidine catabolic process (GO:0006216)4.88297195
4cytidine deamination (GO:0009972)4.88297195
5proteasome assembly (GO:0043248)4.77318554
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60955305
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60055159
8ATP synthesis coupled proton transport (GO:0015986)4.19395897
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19395897
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.11093889
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96214286
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80934485
13regulation of cellular amino acid metabolic process (GO:0006521)3.79569385
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.77170108
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74063005
16respiratory chain complex IV assembly (GO:0008535)3.69478520
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.57458815
18platelet dense granule organization (GO:0060155)3.55644463
19protein complex biogenesis (GO:0070271)3.53619874
20protein neddylation (GO:0045116)3.53190336
21signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50979105
22signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50979105
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50979105
24respiratory electron transport chain (GO:0022904)3.49051836
25electron transport chain (GO:0022900)3.46036345
26rRNA modification (GO:0000154)3.46033087
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45614893
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45440410
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45440410
30negative regulation of ligase activity (GO:0051352)3.38687373
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38687373
32cytochrome complex assembly (GO:0017004)3.34671845
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.30154990
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30154990
35mitochondrial respiratory chain complex assembly (GO:0033108)3.29969114
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28165281
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.27051459
38chaperone-mediated protein transport (GO:0072321)3.24211506
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.17372447
40water-soluble vitamin biosynthetic process (GO:0042364)3.16118571
41ribosomal small subunit assembly (GO:0000028)3.14531971
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13150599
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12859663
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.12859663
45NADH dehydrogenase complex assembly (GO:0010257)3.12859663
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12040743
47kynurenine metabolic process (GO:0070189)3.10884995
48positive regulation of defense response to virus by host (GO:0002230)3.05405674
49response to pheromone (GO:0019236)3.02806073
50mannosylation (GO:0097502)3.01826293
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99887885
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99436547
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99436547
54iron-sulfur cluster assembly (GO:0016226)2.95538029
55metallo-sulfur cluster assembly (GO:0031163)2.95538029
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93203203
57DNA demethylation (GO:0080111)2.91412014
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.90030570
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87560971
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87316696
61termination of RNA polymerase III transcription (GO:0006386)2.86996868
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.86996868
63rRNA methylation (GO:0031167)2.82807646
64DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81466823
65positive regulation of protein homodimerization activity (GO:0090073)2.81138175
66indole-containing compound catabolic process (GO:0042436)2.80476730
67indolalkylamine catabolic process (GO:0046218)2.80476730
68tryptophan catabolic process (GO:0006569)2.80476730
69GPI anchor biosynthetic process (GO:0006506)2.80025293
70protein deneddylation (GO:0000338)2.77776193
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77095691
72L-methionine salvage (GO:0071267)2.75776816
73L-methionine biosynthetic process (GO:0071265)2.75776816
74amino acid salvage (GO:0043102)2.75776816
75negative regulation by host of viral transcription (GO:0043922)2.74985580
76GPI anchor metabolic process (GO:0006505)2.74177209
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.73669242
78positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.72731995
79positive regulation of ligase activity (GO:0051351)2.72160550
80pseudouridine synthesis (GO:0001522)2.71703705
81regulation of cellular amine metabolic process (GO:0033238)2.67680948
82somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66067466
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66067466
84isotype switching (GO:0045190)2.66067466
85positive regulation of cell cycle arrest (GO:0071158)2.63305326
86cullin deneddylation (GO:0010388)2.60612605
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58809740
88antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58287673
89S-adenosylmethionine metabolic process (GO:0046500)2.58184954
90hydrogen ion transmembrane transport (GO:1902600)2.54814685
91regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.53111892
92DNA dealkylation (GO:0035510)2.52982856
93preassembly of GPI anchor in ER membrane (GO:0016254)2.50827926
94proton transport (GO:0015992)2.49897425
95positive regulation of interleukin-17 production (GO:0032740)2.48109821
96hydrogen transport (GO:0006818)2.47340254
97cellular response to interleukin-15 (GO:0071350)2.47079646
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46837208
99regulation of mitotic spindle checkpoint (GO:1903504)2.46837208
100response to interferon-beta (GO:0035456)2.46498502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.35230672
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.95808618
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.95462158
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.34085342
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95519354
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93716769
7VDR_22108803_ChIP-Seq_LS180_Human2.86655843
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85014381
9VDR_23849224_ChIP-Seq_CD4+_Human2.80292178
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73876366
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58445287
12ZNF274_21170338_ChIP-Seq_K562_Hela2.56800643
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43317948
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.40524018
15ELK1_19687146_ChIP-ChIP_HELA_Human2.38639452
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.30044425
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.22266957
18FOXP3_21729870_ChIP-Seq_TREG_Human2.15702007
19IGF1R_20145208_ChIP-Seq_DFB_Human2.13378483
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12657695
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04894309
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.00009027
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98402468
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95598995
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93459401
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86174617
27EWS_26573619_Chip-Seq_HEK293_Human1.84764242
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78086093
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.71196513
30MYC_18940864_ChIP-ChIP_HL60_Human1.69094157
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67988226
32TAF15_26573619_Chip-Seq_HEK293_Human1.62247901
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.61056259
34TP53_22573176_ChIP-Seq_HFKS_Human1.59942753
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57854898
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56969985
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54540960
38FUS_26573619_Chip-Seq_HEK293_Human1.50964738
39GATA3_26560356_Chip-Seq_TH2_Human1.48947490
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46588575
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.44293771
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44293771
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42842976
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42284863
45MYB_26560356_Chip-Seq_TH2_Human1.41361985
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39239607
47AR_20517297_ChIP-Seq_VCAP_Human1.36469268
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36312646
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.32476045
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32125799
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31927539
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31826560
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31522218
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26289235
55NANOG_19829295_ChIP-Seq_ESCs_Human1.23748668
56SOX2_19829295_ChIP-Seq_ESCs_Human1.23748668
57DCP1A_22483619_ChIP-Seq_HELA_Human1.23530923
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22362771
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22332955
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22174448
61ER_23166858_ChIP-Seq_MCF-7_Human1.21807718
62P300_19829295_ChIP-Seq_ESCs_Human1.19590883
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19389986
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18372674
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14374237
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.13879583
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13563719
68ERG_20517297_ChIP-Seq_VCAP_Human1.13543640
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12649542
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12558235
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11713227
72TTF2_22483619_ChIP-Seq_HELA_Human1.11545464
73GABP_19822575_ChIP-Seq_HepG2_Human1.10249647
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09132252
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09125017
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08811946
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08636782
78CBP_20019798_ChIP-Seq_JUKART_Human1.06379140
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06379140
80NCOR_22424771_ChIP-Seq_293T_Human1.05827991
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05049756
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.04993374
83GATA3_27048872_Chip-Seq_THYMUS_Human1.03994954
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03917173
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03587496
86HTT_18923047_ChIP-ChIP_STHdh_Human1.03471193
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03379352
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03219970
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.02554046
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.01271803
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99978207
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99466014
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98039761
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97823865
95IRF1_19129219_ChIP-ChIP_H3396_Human0.96472722
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.96460767
97GATA3_26560356_Chip-Seq_TH1_Human0.95766126
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.95420667
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94716813
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94502167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.99633640
2MP0001835_abnormal_antigen_presentation3.75981884
3MP0002102_abnormal_ear_morphology2.65134878
4MP0006072_abnormal_retinal_apoptosis2.45870550
5MP0009785_altered_susceptibility_to2.44914678
6MP0000372_irregular_coat_pigmentation2.27113806
7MP0003786_premature_aging2.18113915
8MP0006292_abnormal_olfactory_placode2.13579367
9MP0005084_abnormal_gallbladder_morpholo2.12371026
10MP0004147_increased_porphyrin_level2.06140620
11MP0002166_altered_tumor_susceptibility1.97554302
12MP0008877_abnormal_DNA_methylation1.97428090
13MP0001800_abnormal_humoral_immune1.95503679
14MP0002837_dystrophic_cardiac_calcinosis1.92254357
15MP0002148_abnormal_hypersensitivity_rea1.91790798
16MP0006036_abnormal_mitochondrial_physio1.88618022
17MP0003806_abnormal_nucleotide_metabolis1.88315981
18MP0003195_calcinosis1.85804987
19MP0009333_abnormal_splenocyte_physiolog1.82859777
20MP0008872_abnormal_physiological_respon1.81400098
21MP0002876_abnormal_thyroid_physiology1.80343028
22MP0005075_abnormal_melanosome_morpholog1.71740835
23MP0002006_tumorigenesis1.68709193
24MP0005646_abnormal_pituitary_gland1.66909623
25MP0001986_abnormal_taste_sensitivity1.66836096
26MP0005000_abnormal_immune_tolerance1.65672633
27MP0001873_stomach_inflammation1.55774058
28MP0003763_abnormal_thymus_physiology1.55434191
29MP0005253_abnormal_eye_physiology1.55281158
30MP0002723_abnormal_immune_serum1.53582190
31MP0008058_abnormal_DNA_repair1.52257883
32MP0008875_abnormal_xenobiotic_pharmacok1.51653140
33MP0004145_abnormal_muscle_electrophysio1.50017913
34MP0005645_abnormal_hypothalamus_physiol1.47661569
35MP0005551_abnormal_eye_electrophysiolog1.47489435
36MP0000685_abnormal_immune_system1.46366722
37MP0002452_abnormal_antigen_presenting1.43817739
38MP0008995_early_reproductive_senescence1.43629731
39MP0003718_maternal_effect1.43488191
40MP0002420_abnormal_adaptive_immunity1.42763364
41MP0003011_delayed_dark_adaptation1.42726969
42MP0001819_abnormal_immune_cell1.42162523
43MP0005387_immune_system_phenotype1.39493643
44MP0001790_abnormal_immune_system1.39493643
45MP0002163_abnormal_gland_morphology1.36835375
46MP0009697_abnormal_copulation1.30362219
47MP0003646_muscle_fatigue1.29975180
48MP0003866_abnormal_defecation1.28876355
49MP0001764_abnormal_homeostasis1.28551247
50MP0001919_abnormal_reproductive_system1.28221086
51MP0003724_increased_susceptibility_to1.27475118
52MP0005025_abnormal_response_to1.27466291
53MP0001968_abnormal_touch/_nociception1.27008160
54MP0005389_reproductive_system_phenotype1.22483767
55MP0006082_CNS_inflammation1.22378377
56MP0002736_abnormal_nociception_after1.17115299
57MP0006035_abnormal_mitochondrial_morpho1.16377942
58MP0009764_decreased_sensitivity_to1.12951647
59MP0002398_abnormal_bone_marrow1.11522872
60MP0010155_abnormal_intestine_physiology1.10960516
61MP0000716_abnormal_immune_system1.10411054
62MP0002138_abnormal_hepatobiliary_system1.08363991
63MP0001905_abnormal_dopamine_level1.08150870
64MP0000689_abnormal_spleen_morphology1.07904737
65MP0003252_abnormal_bile_duct1.02665710
66MP0010094_abnormal_chromosome_stability1.02625033
67MP0001845_abnormal_inflammatory_respons1.02128717
68MP0005379_endocrine/exocrine_gland_phen1.00908127
69MP0008007_abnormal_cellular_replicative0.99854329
70MP0003880_abnormal_central_pattern0.95481699
71MP0006276_abnormal_autonomic_nervous0.93393619
72MP0002095_abnormal_skin_pigmentation0.91523723
73MP0003186_abnormal_redox_activity0.91344840
74MP0002722_abnormal_immune_system0.90999673
75MP0002429_abnormal_blood_cell0.89651203
76MP0002693_abnormal_pancreas_physiology0.88479891
77MP0001529_abnormal_vocalization0.88404372
78MP0000465_gastrointestinal_hemorrhage0.87043521
79MP0005332_abnormal_amino_acid0.86912221
80MP0001661_extended_life_span0.86908799
81MP0005410_abnormal_fertilization0.84169390
82MP0002405_respiratory_system_inflammati0.83814101
83MP0008469_abnormal_protein_level0.83773402
84MP0004142_abnormal_muscle_tone0.83076622
85MP0000703_abnormal_thymus_morphology0.82292083
86MP0005636_abnormal_mineral_homeostasis0.81354252
87MP0001853_heart_inflammation0.80335241
88MP0002234_abnormal_pharynx_morphology0.80259248
89MP0003567_abnormal_fetal_cardiomyocyte0.79880013
90MP0002419_abnormal_innate_immunity0.76365534
91MP0003787_abnormal_imprinting0.76181285
92MP0001293_anophthalmia0.76075632
93MP0005085_abnormal_gallbladder_physiolo0.75777526
94MP0002090_abnormal_vision0.75463124
95MP0001119_abnormal_female_reproductive0.74838749
96MP0002019_abnormal_tumor_incidence0.73835996
97MP0004215_abnormal_myocardial_fiber0.72719767
98MP0010386_abnormal_urinary_bladder0.70934689
99MP0002160_abnormal_reproductive_system0.69311029
100MP0009763_increased_sensitivity_to0.68065088

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.19459162
2Increased CSF lactate (HP:0002490)4.00818260
3Acute necrotizing encephalopathy (HP:0006965)3.96516546
4Hepatocellular necrosis (HP:0001404)3.90877995
5IgG deficiency (HP:0004315)3.70347675
6Stomatitis (HP:0010280)3.68749905
7Increased hepatocellular lipid droplets (HP:0006565)3.61120818
8Hepatic necrosis (HP:0002605)3.57833704
9Abnormal mitochondria in muscle tissue (HP:0008316)3.56682299
10Lipid accumulation in hepatocytes (HP:0006561)3.42855755
11Progressive macrocephaly (HP:0004481)3.40007480
12Severe combined immunodeficiency (HP:0004430)3.38759331
13Acute encephalopathy (HP:0006846)3.28425575
14Hypoproteinemia (HP:0003075)3.25989109
15T lymphocytopenia (HP:0005403)3.22703082
16Elevated erythrocyte sedimentation rate (HP:0003565)3.21501294
17Abnormality of the prostate (HP:0008775)3.14649574
18Abnormality of T cell number (HP:0011839)3.08451890
19Aplastic anemia (HP:0001915)3.08347700
20Abnormality of B cell number (HP:0010975)3.06292367
21Renal Fanconi syndrome (HP:0001994)3.01200009
22Increased serum lactate (HP:0002151)2.97445885
23Thyroiditis (HP:0100646)2.94987224
24B lymphocytopenia (HP:0010976)2.91622840
25Congenital stationary night blindness (HP:0007642)2.88785069
263-Methylglutaconic aciduria (HP:0003535)2.84997713
27Methylmalonic acidemia (HP:0002912)2.81869701
28Pancreatic cysts (HP:0001737)2.80381766
29Increased intramyocellular lipid droplets (HP:0012240)2.78617266
30Cerebral edema (HP:0002181)2.75367735
31Congenital, generalized hypertrichosis (HP:0004540)2.71957040
32Abolished electroretinogram (ERG) (HP:0000550)2.69335119
33Combined immunodeficiency (HP:0005387)2.58622004
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57685440
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57685440
36Abnormality of alanine metabolism (HP:0010916)2.54615159
37Hyperalaninemia (HP:0003348)2.54615159
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54615159
39Lactic acidosis (HP:0003128)2.54052969
40Abnormality of midbrain morphology (HP:0002418)2.50117754
41Molar tooth sign on MRI (HP:0002419)2.50117754
42Abnormality of T cells (HP:0002843)2.49960549
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48263893
44Panhypogammaglobulinemia (HP:0003139)2.44604585
45Optic disc pallor (HP:0000543)2.39379481
46Decreased central vision (HP:0007663)2.37958613
47Exertional dyspnea (HP:0002875)2.37313048
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36349405
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36061356
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35355876
51Increased muscle lipid content (HP:0009058)2.33281570
52Methylmalonic aciduria (HP:0012120)2.29967082
53Type 2 muscle fiber atrophy (HP:0003554)2.26174658
54True hermaphroditism (HP:0010459)2.22032714
55Abnormal rod and cone electroretinograms (HP:0008323)2.21300553
56Abnormality of eosinophils (HP:0001879)2.18739878
57Nephronophthisis (HP:0000090)2.18122446
58Respiratory failure (HP:0002878)2.17446105
59Lethargy (HP:0001254)2.17142935
60Type I transferrin isoform profile (HP:0003642)2.15533857
61CNS demyelination (HP:0007305)2.11698601
62Attenuation of retinal blood vessels (HP:0007843)2.11401497
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07693258
64Pancreatic fibrosis (HP:0100732)2.07642665
65Pancytopenia (HP:0001876)2.03979833
66Constricted visual fields (HP:0001133)2.02810120
67Prostate neoplasm (HP:0100787)2.00220546
68Aplasia/hypoplasia of the uterus (HP:0008684)1.98766269
69Recurrent bronchitis (HP:0002837)1.95588064
70Short tibia (HP:0005736)1.94724105
71Exercise intolerance (HP:0003546)1.94202298
72Hypothermia (HP:0002045)1.91469508
73Eosinophilia (HP:0001880)1.91087367
74IgM deficiency (HP:0002850)1.90800051
75Oral leukoplakia (HP:0002745)1.86304910
76Dicarboxylic aciduria (HP:0003215)1.85672956
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85672956
78Agammaglobulinemia (HP:0004432)1.84987634
79Abnormality of serum amino acid levels (HP:0003112)1.84161728
80Glycosuria (HP:0003076)1.84149500
81Abnormality of urine glucose concentration (HP:0011016)1.84149500
82Autoimmune hemolytic anemia (HP:0001890)1.83042968
83Abnormality of male internal genitalia (HP:0000022)1.81954939
84Chronic sinusitis (HP:0011109)1.81796786
85Muscle fiber atrophy (HP:0100295)1.80300105
86Abnormality of macular pigmentation (HP:0008002)1.78281549
87Palpitations (HP:0001962)1.76611540
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76544305
89Abnormal protein N-linked glycosylation (HP:0012347)1.76544305
90Abnormal protein glycosylation (HP:0012346)1.76544305
91Abnormal glycosylation (HP:0012345)1.76544305
92Abnormality of renal resorption (HP:0011038)1.75961991
93Medial flaring of the eyebrow (HP:0010747)1.75845640
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.75744278
95Colon cancer (HP:0003003)1.75728500
96Supernumerary spleens (HP:0009799)1.75668430
97Leukodystrophy (HP:0002415)1.75006073
98Abnormality of the renal medulla (HP:0100957)1.74606373
99Progressive microcephaly (HP:0000253)1.71395284
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.70057083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.14427388
2MAP4K23.41131887
3EIF2AK33.33074341
4VRK22.77506241
5ZAK2.75106099
6NUAK12.64787225
7TESK22.46208805
8MST42.38927115
9STK162.28281655
10KDR2.26033339
11GRK12.16504439
12BCKDK2.13436516
13TAOK32.01686062
14TLK12.00351602
15CDK191.92480117
16FRK1.89163595
17ADRBK21.79495566
18EIF2AK11.79393730
19BMPR21.67211270
20ITK1.52271492
21VRK11.45136492
22TEC1.42327250
23BUB11.40341880
24ERBB31.37646773
25BMPR1B1.28458314
26TRIM281.28364877
27PLK41.26246361
28MAP4K11.22137844
29SRPK11.12475378
30PINK11.11805429
31OXSR11.11675332
32SCYL21.11228527
33WNK31.10520644
34MKNK11.07109326
35DAPK11.06159864
36EIF2AK21.05362023
37MAP3K121.04549190
38PLK31.03405209
39INSRR1.02876432
40CSNK1G11.01724871
41KIT0.99819456
42IKBKB0.99502996
43FES0.98671433
44PBK0.96929724
45SYK0.93556107
46CSNK1G30.90997004
47CSF1R0.87653755
48NME10.86584175
49PLK20.82911060
50WNK40.82634224
51PIK3CG0.82197668
52MKNK20.76326051
53BTK0.74613567
54MYLK0.74248233
55TSSK60.71974323
56CSNK1G20.71326822
57FLT30.71291056
58RPS6KA50.70897161
59MUSK0.69695640
60IKBKE0.69633633
61RPS6KA40.69369878
62PRKCQ0.69176364
63DAPK20.66911049
64LYN0.66786308
65LCK0.66742671
66CSNK1A1L0.65491942
67NLK0.65419719
68GRK60.64374355
69MAPKAPK30.62994367
70TIE10.61045111
71MATK0.57392530
72NEK10.57122565
73PHKG10.56678160
74PHKG20.56678160
75STK390.54766858
76ATR0.52906896
77PRKCE0.51413800
78OBSCN0.49545549
79AURKB0.49218476
80CDK30.48307363
81CDC70.48028180
82STK38L0.47442607
83TAF10.46552221
84TNK20.45461365
85GRK70.44538285
86IGF1R0.43792694
87PLK10.43431803
88GRK50.43312182
89TRPM70.43160002
90BCR0.41264683
91CSNK2A10.41086802
92LIMK10.38839235
93PASK0.38643337
94TBK10.38212375
95MAPKAPK50.38212049
96CDK80.38204089
97HCK0.38194734
98MAPK130.36937465
99JAK30.36813337
100PIK3CA0.35542971

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.55271345
2Asthma_Homo sapiens_hsa053103.41559971
3Oxidative phosphorylation_Homo sapiens_hsa001903.13694295
4Allograft rejection_Homo sapiens_hsa053303.08978778
5Autoimmune thyroid disease_Homo sapiens_hsa053203.00365500
6Graft-versus-host disease_Homo sapiens_hsa053322.79469044
7Protein export_Homo sapiens_hsa030602.79042432
8Primary immunodeficiency_Homo sapiens_hsa053402.79001931
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.70244015
10Parkinsons disease_Homo sapiens_hsa050122.62981854
11Type I diabetes mellitus_Homo sapiens_hsa049402.57353698
12RNA polymerase_Homo sapiens_hsa030202.09438499
13Homologous recombination_Homo sapiens_hsa034401.97729232
14Ribosome_Homo sapiens_hsa030101.93849692
15Antigen processing and presentation_Homo sapiens_hsa046121.91505811
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89018353
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67093749
18Rheumatoid arthritis_Homo sapiens_hsa053231.67000753
19Alzheimers disease_Homo sapiens_hsa050101.56765974
20Huntingtons disease_Homo sapiens_hsa050161.55770789
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54401438
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54076912
23RNA degradation_Homo sapiens_hsa030181.52325102
24Propanoate metabolism_Homo sapiens_hsa006401.43985661
25Mismatch repair_Homo sapiens_hsa034301.38927310
26Phototransduction_Homo sapiens_hsa047441.35472046
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32692222
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29392353
29DNA replication_Homo sapiens_hsa030301.27824855
30One carbon pool by folate_Homo sapiens_hsa006701.22793510
31Hematopoietic cell lineage_Homo sapiens_hsa046401.20799500
32Linoleic acid metabolism_Homo sapiens_hsa005911.14499761
33Spliceosome_Homo sapiens_hsa030401.10761494
34Fanconi anemia pathway_Homo sapiens_hsa034601.09885500
35Basal transcription factors_Homo sapiens_hsa030221.08768463
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08213731
37Pyrimidine metabolism_Homo sapiens_hsa002401.06576779
38RNA transport_Homo sapiens_hsa030131.00892168
39Nucleotide excision repair_Homo sapiens_hsa034201.00136788
40Sulfur metabolism_Homo sapiens_hsa009200.95282893
41Cardiac muscle contraction_Homo sapiens_hsa042600.95262463
42Nitrogen metabolism_Homo sapiens_hsa009100.94740149
43Peroxisome_Homo sapiens_hsa041460.94123723
44Non-homologous end-joining_Homo sapiens_hsa034500.92863008
45Purine metabolism_Homo sapiens_hsa002300.92681343
46Tryptophan metabolism_Homo sapiens_hsa003800.91196584
47Viral myocarditis_Homo sapiens_hsa054160.90061292
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89619902
49Butanoate metabolism_Homo sapiens_hsa006500.89068886
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88132797
51Base excision repair_Homo sapiens_hsa034100.82726824
52Systemic lupus erythematosus_Homo sapiens_hsa053220.77320315
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77205727
54Fatty acid elongation_Homo sapiens_hsa000620.73444915
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.71899756
56Staphylococcus aureus infection_Homo sapiens_hsa051500.71523724
57Caffeine metabolism_Homo sapiens_hsa002320.69941105
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67029035
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66993978
60Arachidonic acid metabolism_Homo sapiens_hsa005900.65713458
61Regulation of autophagy_Homo sapiens_hsa041400.64942451
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63511520
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.63322394
64Collecting duct acid secretion_Homo sapiens_hsa049660.62949266
65Selenocompound metabolism_Homo sapiens_hsa004500.61855940
66Olfactory transduction_Homo sapiens_hsa047400.59858472
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58557496
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57998275
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.57187686
70T cell receptor signaling pathway_Homo sapiens_hsa046600.57048599
71Chemical carcinogenesis_Homo sapiens_hsa052040.56001414
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55532731
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53942932
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53363196
75Ether lipid metabolism_Homo sapiens_hsa005650.53272531
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52673475
77Metabolic pathways_Homo sapiens_hsa011000.52386086
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50687319
79Retinol metabolism_Homo sapiens_hsa008300.49707403
80Leishmaniasis_Homo sapiens_hsa051400.49609424
81Herpes simplex infection_Homo sapiens_hsa051680.49507070
82Glutathione metabolism_Homo sapiens_hsa004800.49298303
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48402923
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.45229082
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45000141
86beta-Alanine metabolism_Homo sapiens_hsa004100.44399113
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.43660200
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42985932
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.41923290
90Epstein-Barr virus infection_Homo sapiens_hsa051690.41272233
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40527759
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39689987
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35829994
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35525303
95Measles_Homo sapiens_hsa051620.32944720
96Pyruvate metabolism_Homo sapiens_hsa006200.31809495
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28850862
98Steroid biosynthesis_Homo sapiens_hsa001000.28797110
99Fat digestion and absorption_Homo sapiens_hsa049750.25883807
100Taste transduction_Homo sapiens_hsa047420.21113656

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