NPM1P19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.38927486
2cullin deneddylation (GO:0010388)5.22224204
3maturation of 5.8S rRNA (GO:0000460)5.17313322
4response to pheromone (GO:0019236)4.86810274
5transcription elongation from RNA polymerase III promoter (GO:0006385)4.75386587
6termination of RNA polymerase III transcription (GO:0006386)4.75386587
7protein deneddylation (GO:0000338)4.60262581
8pseudouridine synthesis (GO:0001522)4.50573059
9water-soluble vitamin biosynthetic process (GO:0042364)4.25089950
10DNA deamination (GO:0045006)4.22422207
11regulation of immunoglobulin secretion (GO:0051023)4.09323679
12rRNA modification (GO:0000154)3.93521029
13ribosome assembly (GO:0042255)3.91850325
14rRNA methylation (GO:0031167)3.78163303
15IMP biosynthetic process (GO:0006188)3.71856284
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71405445
17protein complex biogenesis (GO:0070271)3.70829744
18mitochondrial respiratory chain complex assembly (GO:0033108)3.70411429
19positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.63403070
20regulation of cellular amino acid metabolic process (GO:0006521)3.55012038
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52162058
22ribosome biogenesis (GO:0042254)3.51836517
23regulation of mitochondrial translation (GO:0070129)3.51790151
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.49472640
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48632145
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.47021435
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47021435
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44352418
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43034326
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43034326
31isotype switching (GO:0045190)3.43034326
32regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.40130455
33rRNA processing (GO:0006364)3.39621865
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39510011
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39510011
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39510011
37DNA catabolic process, exonucleolytic (GO:0000738)3.38801432
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37872194
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36416295
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36416295
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30482495
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.29499626
43termination of RNA polymerase I transcription (GO:0006363)3.29090570
44rRNA metabolic process (GO:0016072)3.29017641
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27559968
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.27559968
47negative regulation of ligase activity (GO:0051352)3.27427538
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27427538
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.25142775
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24558433
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.23285291
52chromatin remodeling at centromere (GO:0031055)3.19440659
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19036869
54synapsis (GO:0007129)3.18972829
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17268070
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.17268070
57NADH dehydrogenase complex assembly (GO:0010257)3.17268070
58ribosomal small subunit assembly (GO:0000028)3.17196474
59regulation of isotype switching to IgG isotypes (GO:0048302)3.16798718
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15209341
61DNA damage response, detection of DNA damage (GO:0042769)3.14936973
62fucose catabolic process (GO:0019317)3.10619269
63L-fucose metabolic process (GO:0042354)3.10619269
64L-fucose catabolic process (GO:0042355)3.10619269
65replication fork processing (GO:0031297)3.06190921
66CENP-A containing nucleosome assembly (GO:0034080)3.06071305
67IMP metabolic process (GO:0046040)3.04842049
68positive regulation of ligase activity (GO:0051351)3.04761627
69signal peptide processing (GO:0006465)3.01209071
70pteridine-containing compound biosynthetic process (GO:0042559)2.97366721
71cellular component biogenesis (GO:0044085)2.95547240
72amino acid salvage (GO:0043102)2.91652524
73L-methionine salvage (GO:0071267)2.91652524
74L-methionine biosynthetic process (GO:0071265)2.91652524
75formation of translation preinitiation complex (GO:0001731)2.91339974
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89244275
77GMP metabolic process (GO:0046037)2.87445367
78protein K6-linked ubiquitination (GO:0085020)2.87272026
79tRNA processing (GO:0008033)2.85625264
80protein targeting to mitochondrion (GO:0006626)2.85279060
81tRNA metabolic process (GO:0006399)2.84366388
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82374950
83DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81859042
84tRNA modification (GO:0006400)2.81501349
85transcription from RNA polymerase I promoter (GO:0006360)2.81239697
86ncRNA metabolic process (GO:0034660)2.80541364
87histone mRNA metabolic process (GO:0008334)2.80522776
88ncRNA processing (GO:0034470)2.79872846
89somatic diversification of immunoglobulins (GO:0016445)2.79283161
90ribonucleoprotein complex biogenesis (GO:0022613)2.78859406
91spliceosomal snRNP assembly (GO:0000387)2.78097393
92protein-cofactor linkage (GO:0018065)2.76868441
93transcription initiation from RNA polymerase I promoter (GO:0006361)2.75620057
94amino acid activation (GO:0043038)2.74461400
95tRNA aminoacylation (GO:0043039)2.74461400
96DNA-templated transcription, termination (GO:0006353)2.74417547
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74250662
98recombinational repair (GO:0000725)2.73762939
99GTP biosynthetic process (GO:0006183)2.73408267
100maturation of SSU-rRNA (GO:0030490)2.73298729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.09184698
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.44909395
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.55448948
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16206799
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14948141
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.86928378
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78387961
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.71207289
9VDR_23849224_ChIP-Seq_CD4+_Human2.68481171
10E2F7_22180533_ChIP-Seq_HELA_Human2.63426035
11VDR_22108803_ChIP-Seq_LS180_Human2.61151539
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60014406
13ELK1_19687146_ChIP-ChIP_HELA_Human2.57664652
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44620868
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42536059
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40473684
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35513412
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33884812
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29926024
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.29427556
21ZNF274_21170338_ChIP-Seq_K562_Hela2.27073424
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.26310916
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.25443187
24FOXP3_21729870_ChIP-Seq_TREG_Human2.18972496
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.12388600
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03654397
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.91061946
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90177789
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89347348
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88576023
31DCP1A_22483619_ChIP-Seq_HELA_Human1.87209345
32EWS_26573619_Chip-Seq_HEK293_Human1.82646585
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75594284
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74106846
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70194070
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69156524
37MYC_18940864_ChIP-ChIP_HL60_Human1.64080410
38TTF2_22483619_ChIP-Seq_HELA_Human1.60368720
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53745548
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53502674
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53018002
42FUS_26573619_Chip-Seq_HEK293_Human1.49859132
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48282167
44GABP_19822575_ChIP-Seq_HepG2_Human1.47563455
45TP53_22573176_ChIP-Seq_HFKS_Human1.43636797
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43057921
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42999921
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39150577
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38843340
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35112279
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32484711
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30819438
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.30032075
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25919052
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25750884
56P300_19829295_ChIP-Seq_ESCs_Human1.25365323
57TAF15_26573619_Chip-Seq_HEK293_Human1.25248792
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24959166
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22814207
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22744815
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.22278956
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21004637
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19369370
64IRF1_19129219_ChIP-ChIP_H3396_Human1.18287941
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16199242
66SOX2_19829295_ChIP-Seq_ESCs_Human1.14640769
67NANOG_19829295_ChIP-Seq_ESCs_Human1.14640769
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14587255
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.13289522
70XRN2_22483619_ChIP-Seq_HELA_Human1.09970909
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09317822
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08918761
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07623810
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05042161
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04724099
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04148726
77NCOR_22424771_ChIP-Seq_293T_Human1.03308282
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03053648
79ER_23166858_ChIP-Seq_MCF-7_Human1.02501631
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.01849842
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01434800
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00911441
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00818840
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.98963135
85CBP_20019798_ChIP-Seq_JUKART_Human0.97680499
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97680499
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96377371
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.96377371
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96203778
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95374228
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93633853
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93426672
93E2F1_21310950_ChIP-Seq_MCF-7_Human0.93156819
94AR_20517297_ChIP-Seq_VCAP_Human0.92378875
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92240913
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85627712
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84209570
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83221467
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82626461
100PHF8_20622853_ChIP-Seq_HELA_Human0.81807197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.36342645
2MP0010094_abnormal_chromosome_stability3.21363170
3MP0006292_abnormal_olfactory_placode2.95954915
4MP0002102_abnormal_ear_morphology2.87185334
5MP0005084_abnormal_gallbladder_morpholo2.62258155
6MP0004957_abnormal_blastocyst_morpholog2.40530566
7MP0003718_maternal_effect2.39792134
8MP0002254_reproductive_system_inflammat2.36062351
9MP0008877_abnormal_DNA_methylation2.30771939
10MP0001873_stomach_inflammation2.28384984
11MP0003786_premature_aging2.27967759
12MP0005379_endocrine/exocrine_gland_phen2.27726292
13MP0003195_calcinosis2.26718877
14MP0008875_abnormal_xenobiotic_pharmacok2.21497454
15MP0003693_abnormal_embryo_hatching2.20536583
16MP0006036_abnormal_mitochondrial_physio2.09623847
17MP0002138_abnormal_hepatobiliary_system2.06209707
18MP0004147_increased_porphyrin_level1.98890741
19MP0008872_abnormal_physiological_respon1.93360850
20MP0001986_abnormal_taste_sensitivity1.87160576
21MP0003111_abnormal_nucleus_morphology1.82484295
22MP0001968_abnormal_touch/_nociception1.78167752
23MP0003567_abnormal_fetal_cardiomyocyte1.76310063
24MP0002876_abnormal_thyroid_physiology1.73939371
25MP0002736_abnormal_nociception_after1.70271112
26MP0001835_abnormal_antigen_presentation1.69724792
27MP0005551_abnormal_eye_electrophysiolog1.68393867
28MP0001188_hyperpigmentation1.68000099
29MP0002837_dystrophic_cardiac_calcinosis1.63575705
30MP0001984_abnormal_olfaction1.59921469
31MP0005389_reproductive_system_phenotype1.53366639
32MP0000465_gastrointestinal_hemorrhage1.53054248
33MP0001348_abnormal_lacrimal_gland1.52324330
34MP0001919_abnormal_reproductive_system1.48324190
35MP0003077_abnormal_cell_cycle1.44721251
36MP0008057_abnormal_DNA_replication1.42245588
37MP0006072_abnormal_retinal_apoptosis1.38684824
38MP0006035_abnormal_mitochondrial_morpho1.37339179
39MP0005075_abnormal_melanosome_morpholog1.36478659
40MP0002234_abnormal_pharynx_morphology1.35502525
41MP0005646_abnormal_pituitary_gland1.28747612
42MP0002928_abnormal_bile_duct1.24922348
43MP0005310_abnormal_salivary_gland1.23012514
44MP0004885_abnormal_endolymph1.20615426
45MP0001764_abnormal_homeostasis1.18447712
46MP0003646_muscle_fatigue1.17728314
47MP0002160_abnormal_reproductive_system1.17484118
48MP0005645_abnormal_hypothalamus_physiol1.15709586
49MP0002163_abnormal_gland_morphology1.13590721
50MP0004215_abnormal_myocardial_fiber1.12737249
51MP0001853_heart_inflammation1.10319030
52MP0001929_abnormal_gametogenesis1.10269879
53MP0002006_tumorigenesis1.10134113
54MP0001485_abnormal_pinna_reflex1.03882132
55MP0003787_abnormal_imprinting1.03729728
56MP0005410_abnormal_fertilization1.03666904
57MP0003806_abnormal_nucleotide_metabolis1.03031424
58MP0003011_delayed_dark_adaptation1.02603593
59MP0005332_abnormal_amino_acid1.02474577
60MP0005671_abnormal_response_to1.00944319
61MP0009697_abnormal_copulation1.00563507
62MP0002693_abnormal_pancreas_physiology1.00539730
63MP0002210_abnormal_sex_determination0.99981700
64MP0002166_altered_tumor_susceptibility0.99745493
65MP0008007_abnormal_cellular_replicative0.98962984
66MP0009333_abnormal_splenocyte_physiolog0.97777214
67MP0001529_abnormal_vocalization0.96164861
68MP0003186_abnormal_redox_activity0.96001426
69MP0000653_abnormal_sex_gland0.95046781
70MP0002938_white_spotting0.94120824
71MP0001905_abnormal_dopamine_level0.90342007
72MP0006082_CNS_inflammation0.89243634
73MP0005085_abnormal_gallbladder_physiolo0.88977711
74MP0001661_extended_life_span0.88818865
75MP0008932_abnormal_embryonic_tissue0.88779875
76MP0005253_abnormal_eye_physiology0.88707821
77MP0005220_abnormal_exocrine_pancreas0.87029585
78MP0005408_hypopigmentation0.85589058
79MP0005395_other_phenotype0.85205104
80MP0003878_abnormal_ear_physiology0.85123235
81MP0005377_hearing/vestibular/ear_phenot0.85123235
82MP0005636_abnormal_mineral_homeostasis0.83748650
83MP0005365_abnormal_bile_salt0.83146874
84MP0001119_abnormal_female_reproductive0.81936813
85MP0000372_irregular_coat_pigmentation0.80703143
86MP0003252_abnormal_bile_duct0.80203912
87MP0001145_abnormal_male_reproductive0.78864834
88MP0008995_early_reproductive_senescence0.77712573
89MP0010329_abnormal_lipoprotein_level0.77580296
90MP0002396_abnormal_hematopoietic_system0.77108986
91MP0002090_abnormal_vision0.76643085
92MP0009046_muscle_twitch0.76616856
93MP0005387_immune_system_phenotype0.75844791
94MP0001790_abnormal_immune_system0.75844791
95MP0002282_abnormal_trachea_morphology0.75690519
96MP0001293_anophthalmia0.73395197
97MP0002019_abnormal_tumor_incidence0.73002513
98MP0010386_abnormal_urinary_bladder0.72885348
99MP0000685_abnormal_immune_system0.72420261
100MP0000631_abnormal_neuroendocrine_gland0.72136362

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.77519093
2Acute encephalopathy (HP:0006846)3.61526689
3Stomatitis (HP:0010280)3.55223765
4Increased CSF lactate (HP:0002490)3.45744876
5Progressive macrocephaly (HP:0004481)3.42865502
6Mitochondrial inheritance (HP:0001427)3.20220192
7Increased hepatocellular lipid droplets (HP:0006565)3.18493127
8Abnormal mitochondria in muscle tissue (HP:0008316)3.16430172
93-Methylglutaconic aciduria (HP:0003535)3.15229533
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11377937
11Abnormality of alanine metabolism (HP:0010916)3.11377937
12Hyperalaninemia (HP:0003348)3.11377937
13Lipid accumulation in hepatocytes (HP:0006561)3.01323178
14Rhabdomyosarcoma (HP:0002859)2.93357420
15Increased serum lactate (HP:0002151)2.85955813
16Methylmalonic acidemia (HP:0002912)2.84825547
17Cerebral hypomyelination (HP:0006808)2.84663505
18Colon cancer (HP:0003003)2.76790071
19Cerebral edema (HP:0002181)2.67416674
20Hepatocellular necrosis (HP:0001404)2.58363060
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54033752
22Methylmalonic aciduria (HP:0012120)2.52263334
23Progressive inability to walk (HP:0002505)2.49523673
24IgG deficiency (HP:0004315)2.47835107
25Hyperglycinemia (HP:0002154)2.45216877
26Pancreatic cysts (HP:0001737)2.44676433
27Molar tooth sign on MRI (HP:0002419)2.42623181
28Abnormality of midbrain morphology (HP:0002418)2.42623181
29Hepatic necrosis (HP:0002605)2.42237513
30Aplasia/hypoplasia of the uterus (HP:0008684)2.41230152
31Congenital stationary night blindness (HP:0007642)2.40471271
32Lactic acidosis (HP:0003128)2.39488033
33Limb hypertonia (HP:0002509)2.35423611
34Optic disc pallor (HP:0000543)2.29851409
35Abnormality of the renal cortex (HP:0011035)2.28841280
36Hyperglycinuria (HP:0003108)2.26808092
37Abnormality of the labia minora (HP:0012880)2.26750636
38Lethargy (HP:0001254)2.25587696
39Renal Fanconi syndrome (HP:0001994)2.23143197
40Abnormality of serum amino acid levels (HP:0003112)2.22245753
41Abnormality of the pons (HP:0007361)2.20251097
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19636869
43Abnormal rod and cone electroretinograms (HP:0008323)2.17650521
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17237243
45Progressive microcephaly (HP:0000253)2.15649798
46Abnormality of methionine metabolism (HP:0010901)2.13344769
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12056004
48Hypoplasia of the uterus (HP:0000013)2.11900195
49Meckel diverticulum (HP:0002245)2.11888325
50CNS hypomyelination (HP:0003429)2.11498842
51Ependymoma (HP:0002888)2.10658277
52Multiple enchondromatosis (HP:0005701)2.09987352
53Abnormality of the preputium (HP:0100587)2.09055329
54Inability to walk (HP:0002540)2.08620747
55Renal cortical cysts (HP:0000803)2.07520971
56Abnormality of glycine metabolism (HP:0010895)2.06559413
57Abnormality of serine family amino acid metabolism (HP:0010894)2.06559413
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06419234
59Meningioma (HP:0002858)2.03745711
60Oral leukoplakia (HP:0002745)2.03041892
61Leukodystrophy (HP:0002415)2.02288482
62Abnormality of the ileum (HP:0001549)2.01690246
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01430609
64Respiratory failure (HP:0002878)1.99304436
65Hypoproteinemia (HP:0003075)1.97933290
66Abnormality of urine glucose concentration (HP:0011016)1.97303245
67Glycosuria (HP:0003076)1.97303245
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95302292
69Glioma (HP:0009733)1.92958218
70CNS demyelination (HP:0007305)1.92796431
71Pancytopenia (HP:0001876)1.92481475
72Volvulus (HP:0002580)1.91528007
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.90694276
74Abnormality of vitamin B metabolism (HP:0004340)1.88898863
75Respiratory difficulties (HP:0002880)1.88121348
76Horseshoe kidney (HP:0000085)1.87566126
77Conjunctival hamartoma (HP:0100780)1.85325618
78Testicular atrophy (HP:0000029)1.84236255
79True hermaphroditism (HP:0010459)1.84043468
80Hypoplasia of the pons (HP:0012110)1.83874559
81Bile duct proliferation (HP:0001408)1.83037998
82Abnormal biliary tract physiology (HP:0012439)1.83037998
83Neuroendocrine neoplasm (HP:0100634)1.82562572
84Opisthotonus (HP:0002179)1.80581247
85Nephronophthisis (HP:0000090)1.80145926
86Type I transferrin isoform profile (HP:0003642)1.79816049
87Duplicated collecting system (HP:0000081)1.79577303
88Severe global developmental delay (HP:0011344)1.78885540
89Abnormality of the renal medulla (HP:0100957)1.78596028
90Abnormality of the renal collecting system (HP:0004742)1.76374839
91Abnormal number of erythroid precursors (HP:0012131)1.75996133
92Panhypogammaglobulinemia (HP:0003139)1.74508156
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.73425545
94Clubbing of toes (HP:0100760)1.71655062
95Constricted visual fields (HP:0001133)1.71652896
96Exertional dyspnea (HP:0002875)1.71252346
97Abnormality of the astrocytes (HP:0100707)1.70434201
98Astrocytoma (HP:0009592)1.70434201
99Exercise intolerance (HP:0003546)1.70190727
100Chromsome breakage (HP:0040012)1.68153518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.56017316
2TSSK64.05490579
3EIF2AK13.77177142
4BUB13.04027524
5NLK2.74121423
6MST42.67723092
7ZAK2.52982828
8VRK22.44724916
9SRPK12.34685275
10PBK2.30335873
11FRK2.20571817
12TLK12.08919459
13NUAK11.98822049
14MKNK21.86855740
15CSNK1G11.85460475
16PDK21.83665994
17PLK31.74417418
18MAPKAPK31.71431948
19OXSR11.64965296
20STK391.56937995
21MKNK11.55407113
22TRIM281.55400862
23ADRBK21.53598396
24NEK11.52803616
25VRK11.51239522
26WNK31.50248715
27GRK11.46871324
28BRSK21.42751710
29PLK21.37102656
30BMPR1B1.36436632
31EIF2AK21.36123953
32WNK41.35947406
33AKT31.35049584
34TNIK1.33164591
35CSNK1A1L1.23790744
36NME11.23086401
37CAMKK21.20394312
38CSNK1G31.12552287
39TAF11.07727575
40CDK191.03928033
41MAP4K21.00635524
42RPS6KB20.99533205
43ALK0.96928653
44BCR0.96885012
45PLK10.94300739
46TEC0.89516418
47MAPK130.83680226
48CSNK1G20.79961161
49PLK40.79385636
50ACVR1B0.78830685
51TXK0.75218155
52SGK20.75153819
53WEE10.72983545
54STK160.72200634
55MAP2K60.70252360
56TAOK30.69038798
57MAP3K40.68636995
58CDC70.68149728
59STK40.67225495
60PHKG20.66272376
61PHKG10.66272376
62PASK0.66047292
63CDK30.64503919
64IKBKB0.63629429
65TIE10.61782531
66BRD40.61700048
67MAPKAPK50.60277999
68STK30.59857846
69AURKB0.59624588
70RPS6KA50.59320700
71RPS6KA40.56398882
72MAP2K70.54636076
73ATR0.54316267
74PRKCE0.54170798
75TTK0.46448610
76STK38L0.44834780
77DYRK20.42820558
78CSNK2A20.41874751
79CSNK2A10.41446518
80TGFBR10.39951127
81PRKCI0.39709752
82INSRR0.38322593
83DAPK10.38093725
84PRKCG0.37599742
85EPHA30.36306483
86SIK30.35836296
87IKBKE0.35415568
88NME20.34424400
89ATM0.30224390
90PAK30.29562053
91CCNB10.29394015
92CSNK1A10.29116760
93CSNK1E0.29037258
94FGFR10.23783629
95CHEK10.23425003
96BRSK10.22938539
97CAMK2D0.21389016
98PAK40.21312862
99PNCK0.20952093
100PINK10.20307901

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67553314
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47602611
3RNA polymerase_Homo sapiens_hsa030203.44865696
4Protein export_Homo sapiens_hsa030602.73946275
5One carbon pool by folate_Homo sapiens_hsa006702.54233031
6Mismatch repair_Homo sapiens_hsa034302.51237542
7Homologous recombination_Homo sapiens_hsa034402.38978450
8Oxidative phosphorylation_Homo sapiens_hsa001902.23915353
9DNA replication_Homo sapiens_hsa030302.22419257
10Ribosome_Homo sapiens_hsa030102.22154947
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13877108
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13045390
13Basal transcription factors_Homo sapiens_hsa030222.11228589
14Fanconi anemia pathway_Homo sapiens_hsa034602.02936393
15Propanoate metabolism_Homo sapiens_hsa006401.91790424
16RNA degradation_Homo sapiens_hsa030181.85970789
17RNA transport_Homo sapiens_hsa030131.84497057
18Parkinsons disease_Homo sapiens_hsa050121.84493131
19Spliceosome_Homo sapiens_hsa030401.78768134
20Non-homologous end-joining_Homo sapiens_hsa034501.78463821
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77990214
22Vitamin B6 metabolism_Homo sapiens_hsa007501.74968349
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64622012
24Pyrimidine metabolism_Homo sapiens_hsa002401.56297432
25Nitrogen metabolism_Homo sapiens_hsa009101.49353866
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.49102793
27Asthma_Homo sapiens_hsa053101.48869763
28Nucleotide excision repair_Homo sapiens_hsa034201.34375142
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.33619659
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29565227
31Huntingtons disease_Homo sapiens_hsa050161.27898144
32Allograft rejection_Homo sapiens_hsa053301.27299252
33Phototransduction_Homo sapiens_hsa047441.27146491
34Base excision repair_Homo sapiens_hsa034101.26986276
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25315791
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24089971
37Autoimmune thyroid disease_Homo sapiens_hsa053201.23770720
38Fatty acid elongation_Homo sapiens_hsa000621.18281235
39Purine metabolism_Homo sapiens_hsa002301.17421712
40Caffeine metabolism_Homo sapiens_hsa002321.14734498
41Primary immunodeficiency_Homo sapiens_hsa053401.13207328
42Linoleic acid metabolism_Homo sapiens_hsa005911.08625196
43Folate biosynthesis_Homo sapiens_hsa007901.08573176
44Peroxisome_Homo sapiens_hsa041461.06701312
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04065593
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00577514
47Selenocompound metabolism_Homo sapiens_hsa004500.92071598
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90961944
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90414749
50Sulfur metabolism_Homo sapiens_hsa009200.90008750
51Alzheimers disease_Homo sapiens_hsa050100.89128309
52Pyruvate metabolism_Homo sapiens_hsa006200.87809434
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74448713
54Ether lipid metabolism_Homo sapiens_hsa005650.73318129
55Type I diabetes mellitus_Homo sapiens_hsa049400.71632710
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71371597
57Tryptophan metabolism_Homo sapiens_hsa003800.70728625
58Collecting duct acid secretion_Homo sapiens_hsa049660.66510223
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66151473
60Systemic lupus erythematosus_Homo sapiens_hsa053220.65992294
61Fatty acid metabolism_Homo sapiens_hsa012120.65780012
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.63810405
63Regulation of autophagy_Homo sapiens_hsa041400.63794762
64Metabolic pathways_Homo sapiens_hsa011000.63614167
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62690908
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.60508746
67Graft-versus-host disease_Homo sapiens_hsa053320.59552748
68Glutathione metabolism_Homo sapiens_hsa004800.58917974
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57281474
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55513512
71beta-Alanine metabolism_Homo sapiens_hsa004100.54939062
72Butanoate metabolism_Homo sapiens_hsa006500.54223837
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.53109320
74Carbon metabolism_Homo sapiens_hsa012000.51411532
75Chemical carcinogenesis_Homo sapiens_hsa052040.50861559
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49827529
77Cell cycle_Homo sapiens_hsa041100.48963140
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48722738
79Fatty acid degradation_Homo sapiens_hsa000710.48319066
80Epstein-Barr virus infection_Homo sapiens_hsa051690.47735281
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47689350
82Legionellosis_Homo sapiens_hsa051340.46880336
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.46537805
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44572746
85p53 signaling pathway_Homo sapiens_hsa041150.42063832
86Retinol metabolism_Homo sapiens_hsa008300.41394305
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41051332
88Antigen processing and presentation_Homo sapiens_hsa046120.40740952
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39320231
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39207508
91Circadian rhythm_Homo sapiens_hsa047100.36330847
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34661233
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34513950
94Cardiac muscle contraction_Homo sapiens_hsa042600.33720286
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33598691
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31395524
97Arachidonic acid metabolism_Homo sapiens_hsa005900.30730368
98Sulfur relay system_Homo sapiens_hsa041220.30176005
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29321621
100Rheumatoid arthritis_Homo sapiens_hsa053230.29130613

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »