

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.38927486 |
| 2 | cullin deneddylation (GO:0010388) | 5.22224204 |
| 3 | maturation of 5.8S rRNA (GO:0000460) | 5.17313322 |
| 4 | response to pheromone (GO:0019236) | 4.86810274 |
| 5 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.75386587 |
| 6 | termination of RNA polymerase III transcription (GO:0006386) | 4.75386587 |
| 7 | protein deneddylation (GO:0000338) | 4.60262581 |
| 8 | pseudouridine synthesis (GO:0001522) | 4.50573059 |
| 9 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.25089950 |
| 10 | DNA deamination (GO:0045006) | 4.22422207 |
| 11 | regulation of immunoglobulin secretion (GO:0051023) | 4.09323679 |
| 12 | rRNA modification (GO:0000154) | 3.93521029 |
| 13 | ribosome assembly (GO:0042255) | 3.91850325 |
| 14 | rRNA methylation (GO:0031167) | 3.78163303 |
| 15 | IMP biosynthetic process (GO:0006188) | 3.71856284 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.71405445 |
| 17 | protein complex biogenesis (GO:0070271) | 3.70829744 |
| 18 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.70411429 |
| 19 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.63403070 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.55012038 |
| 21 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.52162058 |
| 22 | ribosome biogenesis (GO:0042254) | 3.51836517 |
| 23 | regulation of mitochondrial translation (GO:0070129) | 3.51790151 |
| 24 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.49472640 |
| 25 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.48632145 |
| 26 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.47021435 |
| 27 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.47021435 |
| 28 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.44352418 |
| 29 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.43034326 |
| 30 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.43034326 |
| 31 | isotype switching (GO:0045190) | 3.43034326 |
| 32 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.40130455 |
| 33 | rRNA processing (GO:0006364) | 3.39621865 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.39510011 |
| 35 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.39510011 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.39510011 |
| 37 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.38801432 |
| 38 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.37872194 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.36416295 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.36416295 |
| 41 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.30482495 |
| 42 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.29499626 |
| 43 | termination of RNA polymerase I transcription (GO:0006363) | 3.29090570 |
| 44 | rRNA metabolic process (GO:0016072) | 3.29017641 |
| 45 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27559968 |
| 46 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27559968 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.27427538 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.27427538 |
| 49 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.25142775 |
| 50 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24558433 |
| 51 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.23285291 |
| 52 | chromatin remodeling at centromere (GO:0031055) | 3.19440659 |
| 53 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.19036869 |
| 54 | synapsis (GO:0007129) | 3.18972829 |
| 55 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.17268070 |
| 56 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.17268070 |
| 57 | NADH dehydrogenase complex assembly (GO:0010257) | 3.17268070 |
| 58 | ribosomal small subunit assembly (GO:0000028) | 3.17196474 |
| 59 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.16798718 |
| 60 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.15209341 |
| 61 | DNA damage response, detection of DNA damage (GO:0042769) | 3.14936973 |
| 62 | fucose catabolic process (GO:0019317) | 3.10619269 |
| 63 | L-fucose metabolic process (GO:0042354) | 3.10619269 |
| 64 | L-fucose catabolic process (GO:0042355) | 3.10619269 |
| 65 | replication fork processing (GO:0031297) | 3.06190921 |
| 66 | CENP-A containing nucleosome assembly (GO:0034080) | 3.06071305 |
| 67 | IMP metabolic process (GO:0046040) | 3.04842049 |
| 68 | positive regulation of ligase activity (GO:0051351) | 3.04761627 |
| 69 | signal peptide processing (GO:0006465) | 3.01209071 |
| 70 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.97366721 |
| 71 | cellular component biogenesis (GO:0044085) | 2.95547240 |
| 72 | amino acid salvage (GO:0043102) | 2.91652524 |
| 73 | L-methionine salvage (GO:0071267) | 2.91652524 |
| 74 | L-methionine biosynthetic process (GO:0071265) | 2.91652524 |
| 75 | formation of translation preinitiation complex (GO:0001731) | 2.91339974 |
| 76 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.89244275 |
| 77 | GMP metabolic process (GO:0046037) | 2.87445367 |
| 78 | protein K6-linked ubiquitination (GO:0085020) | 2.87272026 |
| 79 | tRNA processing (GO:0008033) | 2.85625264 |
| 80 | protein targeting to mitochondrion (GO:0006626) | 2.85279060 |
| 81 | tRNA metabolic process (GO:0006399) | 2.84366388 |
| 82 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.82374950 |
| 83 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.81859042 |
| 84 | tRNA modification (GO:0006400) | 2.81501349 |
| 85 | transcription from RNA polymerase I promoter (GO:0006360) | 2.81239697 |
| 86 | ncRNA metabolic process (GO:0034660) | 2.80541364 |
| 87 | histone mRNA metabolic process (GO:0008334) | 2.80522776 |
| 88 | ncRNA processing (GO:0034470) | 2.79872846 |
| 89 | somatic diversification of immunoglobulins (GO:0016445) | 2.79283161 |
| 90 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.78859406 |
| 91 | spliceosomal snRNP assembly (GO:0000387) | 2.78097393 |
| 92 | protein-cofactor linkage (GO:0018065) | 2.76868441 |
| 93 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.75620057 |
| 94 | amino acid activation (GO:0043038) | 2.74461400 |
| 95 | tRNA aminoacylation (GO:0043039) | 2.74461400 |
| 96 | DNA-templated transcription, termination (GO:0006353) | 2.74417547 |
| 97 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.74250662 |
| 98 | recombinational repair (GO:0000725) | 2.73762939 |
| 99 | GTP biosynthetic process (GO:0006183) | 2.73408267 |
| 100 | maturation of SSU-rRNA (GO:0030490) | 2.73298729 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.09184698 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.44909395 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.55448948 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.16206799 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.14948141 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.86928378 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.78387961 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.71207289 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.68481171 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.63426035 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.61151539 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.60014406 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.57664652 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.44620868 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.42536059 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.40473684 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.35513412 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.33884812 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.29926024 |
| 20 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.29427556 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.27073424 |
| 22 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.26310916 |
| 23 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.25443187 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.18972496 |
| 25 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.12388600 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.03654397 |
| 27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91061946 |
| 28 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.90177789 |
| 29 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.89347348 |
| 30 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.88576023 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.87209345 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.82646585 |
| 33 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.75594284 |
| 34 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.74106846 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.70194070 |
| 36 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.69156524 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.64080410 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.60368720 |
| 39 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.53745548 |
| 40 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.53502674 |
| 41 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.53018002 |
| 42 | FUS_26573619_Chip-Seq_HEK293_Human | 1.49859132 |
| 43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.48282167 |
| 44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.47563455 |
| 45 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.43636797 |
| 46 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.43057921 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.42999921 |
| 48 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.39150577 |
| 49 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.38843340 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35112279 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.32484711 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.30819438 |
| 53 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.30032075 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.25919052 |
| 55 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.25750884 |
| 56 | P300_19829295_ChIP-Seq_ESCs_Human | 1.25365323 |
| 57 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.25248792 |
| 58 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.24959166 |
| 59 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.22814207 |
| 60 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.22744815 |
| 61 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.22278956 |
| 62 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.21004637 |
| 63 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19369370 |
| 64 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.18287941 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.16199242 |
| 66 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.14640769 |
| 67 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.14640769 |
| 68 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.14587255 |
| 69 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.13289522 |
| 70 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.09970909 |
| 71 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.09317822 |
| 72 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.08918761 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07623810 |
| 74 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05042161 |
| 75 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.04724099 |
| 76 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.04148726 |
| 77 | NCOR_22424771_ChIP-Seq_293T_Human | 1.03308282 |
| 78 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.03053648 |
| 79 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.02501631 |
| 80 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.01849842 |
| 81 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.01434800 |
| 82 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.00911441 |
| 83 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00818840 |
| 84 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.98963135 |
| 85 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.97680499 |
| 86 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.97680499 |
| 87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.96377371 |
| 88 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.96377371 |
| 89 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.96203778 |
| 90 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95374228 |
| 91 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.93633853 |
| 92 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.93426672 |
| 93 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.93156819 |
| 94 | AR_20517297_ChIP-Seq_VCAP_Human | 0.92378875 |
| 95 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.92240913 |
| 96 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.85627712 |
| 97 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.84209570 |
| 98 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83221467 |
| 99 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.82626461 |
| 100 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.81807197 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.36342645 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.21363170 |
| 3 | MP0006292_abnormal_olfactory_placode | 2.95954915 |
| 4 | MP0002102_abnormal_ear_morphology | 2.87185334 |
| 5 | MP0005084_abnormal_gallbladder_morpholo | 2.62258155 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 2.40530566 |
| 7 | MP0003718_maternal_effect | 2.39792134 |
| 8 | MP0002254_reproductive_system_inflammat | 2.36062351 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.30771939 |
| 10 | MP0001873_stomach_inflammation | 2.28384984 |
| 11 | MP0003786_premature_aging | 2.27967759 |
| 12 | MP0005379_endocrine/exocrine_gland_phen | 2.27726292 |
| 13 | MP0003195_calcinosis | 2.26718877 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.21497454 |
| 15 | MP0003693_abnormal_embryo_hatching | 2.20536583 |
| 16 | MP0006036_abnormal_mitochondrial_physio | 2.09623847 |
| 17 | MP0002138_abnormal_hepatobiliary_system | 2.06209707 |
| 18 | MP0004147_increased_porphyrin_level | 1.98890741 |
| 19 | MP0008872_abnormal_physiological_respon | 1.93360850 |
| 20 | MP0001986_abnormal_taste_sensitivity | 1.87160576 |
| 21 | MP0003111_abnormal_nucleus_morphology | 1.82484295 |
| 22 | MP0001968_abnormal_touch/_nociception | 1.78167752 |
| 23 | MP0003567_abnormal_fetal_cardiomyocyte | 1.76310063 |
| 24 | MP0002876_abnormal_thyroid_physiology | 1.73939371 |
| 25 | MP0002736_abnormal_nociception_after | 1.70271112 |
| 26 | MP0001835_abnormal_antigen_presentation | 1.69724792 |
| 27 | MP0005551_abnormal_eye_electrophysiolog | 1.68393867 |
| 28 | MP0001188_hyperpigmentation | 1.68000099 |
| 29 | MP0002837_dystrophic_cardiac_calcinosis | 1.63575705 |
| 30 | MP0001984_abnormal_olfaction | 1.59921469 |
| 31 | MP0005389_reproductive_system_phenotype | 1.53366639 |
| 32 | MP0000465_gastrointestinal_hemorrhage | 1.53054248 |
| 33 | MP0001348_abnormal_lacrimal_gland | 1.52324330 |
| 34 | MP0001919_abnormal_reproductive_system | 1.48324190 |
| 35 | MP0003077_abnormal_cell_cycle | 1.44721251 |
| 36 | MP0008057_abnormal_DNA_replication | 1.42245588 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.38684824 |
| 38 | MP0006035_abnormal_mitochondrial_morpho | 1.37339179 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.36478659 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.35502525 |
| 41 | MP0005646_abnormal_pituitary_gland | 1.28747612 |
| 42 | MP0002928_abnormal_bile_duct | 1.24922348 |
| 43 | MP0005310_abnormal_salivary_gland | 1.23012514 |
| 44 | MP0004885_abnormal_endolymph | 1.20615426 |
| 45 | MP0001764_abnormal_homeostasis | 1.18447712 |
| 46 | MP0003646_muscle_fatigue | 1.17728314 |
| 47 | MP0002160_abnormal_reproductive_system | 1.17484118 |
| 48 | MP0005645_abnormal_hypothalamus_physiol | 1.15709586 |
| 49 | MP0002163_abnormal_gland_morphology | 1.13590721 |
| 50 | MP0004215_abnormal_myocardial_fiber | 1.12737249 |
| 51 | MP0001853_heart_inflammation | 1.10319030 |
| 52 | MP0001929_abnormal_gametogenesis | 1.10269879 |
| 53 | MP0002006_tumorigenesis | 1.10134113 |
| 54 | MP0001485_abnormal_pinna_reflex | 1.03882132 |
| 55 | MP0003787_abnormal_imprinting | 1.03729728 |
| 56 | MP0005410_abnormal_fertilization | 1.03666904 |
| 57 | MP0003806_abnormal_nucleotide_metabolis | 1.03031424 |
| 58 | MP0003011_delayed_dark_adaptation | 1.02603593 |
| 59 | MP0005332_abnormal_amino_acid | 1.02474577 |
| 60 | MP0005671_abnormal_response_to | 1.00944319 |
| 61 | MP0009697_abnormal_copulation | 1.00563507 |
| 62 | MP0002693_abnormal_pancreas_physiology | 1.00539730 |
| 63 | MP0002210_abnormal_sex_determination | 0.99981700 |
| 64 | MP0002166_altered_tumor_susceptibility | 0.99745493 |
| 65 | MP0008007_abnormal_cellular_replicative | 0.98962984 |
| 66 | MP0009333_abnormal_splenocyte_physiolog | 0.97777214 |
| 67 | MP0001529_abnormal_vocalization | 0.96164861 |
| 68 | MP0003186_abnormal_redox_activity | 0.96001426 |
| 69 | MP0000653_abnormal_sex_gland | 0.95046781 |
| 70 | MP0002938_white_spotting | 0.94120824 |
| 71 | MP0001905_abnormal_dopamine_level | 0.90342007 |
| 72 | MP0006082_CNS_inflammation | 0.89243634 |
| 73 | MP0005085_abnormal_gallbladder_physiolo | 0.88977711 |
| 74 | MP0001661_extended_life_span | 0.88818865 |
| 75 | MP0008932_abnormal_embryonic_tissue | 0.88779875 |
| 76 | MP0005253_abnormal_eye_physiology | 0.88707821 |
| 77 | MP0005220_abnormal_exocrine_pancreas | 0.87029585 |
| 78 | MP0005408_hypopigmentation | 0.85589058 |
| 79 | MP0005395_other_phenotype | 0.85205104 |
| 80 | MP0003878_abnormal_ear_physiology | 0.85123235 |
| 81 | MP0005377_hearing/vestibular/ear_phenot | 0.85123235 |
| 82 | MP0005636_abnormal_mineral_homeostasis | 0.83748650 |
| 83 | MP0005365_abnormal_bile_salt | 0.83146874 |
| 84 | MP0001119_abnormal_female_reproductive | 0.81936813 |
| 85 | MP0000372_irregular_coat_pigmentation | 0.80703143 |
| 86 | MP0003252_abnormal_bile_duct | 0.80203912 |
| 87 | MP0001145_abnormal_male_reproductive | 0.78864834 |
| 88 | MP0008995_early_reproductive_senescence | 0.77712573 |
| 89 | MP0010329_abnormal_lipoprotein_level | 0.77580296 |
| 90 | MP0002396_abnormal_hematopoietic_system | 0.77108986 |
| 91 | MP0002090_abnormal_vision | 0.76643085 |
| 92 | MP0009046_muscle_twitch | 0.76616856 |
| 93 | MP0005387_immune_system_phenotype | 0.75844791 |
| 94 | MP0001790_abnormal_immune_system | 0.75844791 |
| 95 | MP0002282_abnormal_trachea_morphology | 0.75690519 |
| 96 | MP0001293_anophthalmia | 0.73395197 |
| 97 | MP0002019_abnormal_tumor_incidence | 0.73002513 |
| 98 | MP0010386_abnormal_urinary_bladder | 0.72885348 |
| 99 | MP0000685_abnormal_immune_system | 0.72420261 |
| 100 | MP0000631_abnormal_neuroendocrine_gland | 0.72136362 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.77519093 |
| 2 | Acute encephalopathy (HP:0006846) | 3.61526689 |
| 3 | Stomatitis (HP:0010280) | 3.55223765 |
| 4 | Increased CSF lactate (HP:0002490) | 3.45744876 |
| 5 | Progressive macrocephaly (HP:0004481) | 3.42865502 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.20220192 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18493127 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.16430172 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.15229533 |
| 10 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.11377937 |
| 11 | Abnormality of alanine metabolism (HP:0010916) | 3.11377937 |
| 12 | Hyperalaninemia (HP:0003348) | 3.11377937 |
| 13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.01323178 |
| 14 | Rhabdomyosarcoma (HP:0002859) | 2.93357420 |
| 15 | Increased serum lactate (HP:0002151) | 2.85955813 |
| 16 | Methylmalonic acidemia (HP:0002912) | 2.84825547 |
| 17 | Cerebral hypomyelination (HP:0006808) | 2.84663505 |
| 18 | Colon cancer (HP:0003003) | 2.76790071 |
| 19 | Cerebral edema (HP:0002181) | 2.67416674 |
| 20 | Hepatocellular necrosis (HP:0001404) | 2.58363060 |
| 21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.54033752 |
| 22 | Methylmalonic aciduria (HP:0012120) | 2.52263334 |
| 23 | Progressive inability to walk (HP:0002505) | 2.49523673 |
| 24 | IgG deficiency (HP:0004315) | 2.47835107 |
| 25 | Hyperglycinemia (HP:0002154) | 2.45216877 |
| 26 | Pancreatic cysts (HP:0001737) | 2.44676433 |
| 27 | Molar tooth sign on MRI (HP:0002419) | 2.42623181 |
| 28 | Abnormality of midbrain morphology (HP:0002418) | 2.42623181 |
| 29 | Hepatic necrosis (HP:0002605) | 2.42237513 |
| 30 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.41230152 |
| 31 | Congenital stationary night blindness (HP:0007642) | 2.40471271 |
| 32 | Lactic acidosis (HP:0003128) | 2.39488033 |
| 33 | Limb hypertonia (HP:0002509) | 2.35423611 |
| 34 | Optic disc pallor (HP:0000543) | 2.29851409 |
| 35 | Abnormality of the renal cortex (HP:0011035) | 2.28841280 |
| 36 | Hyperglycinuria (HP:0003108) | 2.26808092 |
| 37 | Abnormality of the labia minora (HP:0012880) | 2.26750636 |
| 38 | Lethargy (HP:0001254) | 2.25587696 |
| 39 | Renal Fanconi syndrome (HP:0001994) | 2.23143197 |
| 40 | Abnormality of serum amino acid levels (HP:0003112) | 2.22245753 |
| 41 | Abnormality of the pons (HP:0007361) | 2.20251097 |
| 42 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.19636869 |
| 43 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.17650521 |
| 44 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.17237243 |
| 45 | Progressive microcephaly (HP:0000253) | 2.15649798 |
| 46 | Abnormality of methionine metabolism (HP:0010901) | 2.13344769 |
| 47 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.12056004 |
| 48 | Hypoplasia of the uterus (HP:0000013) | 2.11900195 |
| 49 | Meckel diverticulum (HP:0002245) | 2.11888325 |
| 50 | CNS hypomyelination (HP:0003429) | 2.11498842 |
| 51 | Ependymoma (HP:0002888) | 2.10658277 |
| 52 | Multiple enchondromatosis (HP:0005701) | 2.09987352 |
| 53 | Abnormality of the preputium (HP:0100587) | 2.09055329 |
| 54 | Inability to walk (HP:0002540) | 2.08620747 |
| 55 | Renal cortical cysts (HP:0000803) | 2.07520971 |
| 56 | Abnormality of glycine metabolism (HP:0010895) | 2.06559413 |
| 57 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.06559413 |
| 58 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.06419234 |
| 59 | Meningioma (HP:0002858) | 2.03745711 |
| 60 | Oral leukoplakia (HP:0002745) | 2.03041892 |
| 61 | Leukodystrophy (HP:0002415) | 2.02288482 |
| 62 | Abnormality of the ileum (HP:0001549) | 2.01690246 |
| 63 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.01430609 |
| 64 | Respiratory failure (HP:0002878) | 1.99304436 |
| 65 | Hypoproteinemia (HP:0003075) | 1.97933290 |
| 66 | Abnormality of urine glucose concentration (HP:0011016) | 1.97303245 |
| 67 | Glycosuria (HP:0003076) | 1.97303245 |
| 68 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.95302292 |
| 69 | Glioma (HP:0009733) | 1.92958218 |
| 70 | CNS demyelination (HP:0007305) | 1.92796431 |
| 71 | Pancytopenia (HP:0001876) | 1.92481475 |
| 72 | Volvulus (HP:0002580) | 1.91528007 |
| 73 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.90694276 |
| 74 | Abnormality of vitamin B metabolism (HP:0004340) | 1.88898863 |
| 75 | Respiratory difficulties (HP:0002880) | 1.88121348 |
| 76 | Horseshoe kidney (HP:0000085) | 1.87566126 |
| 77 | Conjunctival hamartoma (HP:0100780) | 1.85325618 |
| 78 | Testicular atrophy (HP:0000029) | 1.84236255 |
| 79 | True hermaphroditism (HP:0010459) | 1.84043468 |
| 80 | Hypoplasia of the pons (HP:0012110) | 1.83874559 |
| 81 | Bile duct proliferation (HP:0001408) | 1.83037998 |
| 82 | Abnormal biliary tract physiology (HP:0012439) | 1.83037998 |
| 83 | Neuroendocrine neoplasm (HP:0100634) | 1.82562572 |
| 84 | Opisthotonus (HP:0002179) | 1.80581247 |
| 85 | Nephronophthisis (HP:0000090) | 1.80145926 |
| 86 | Type I transferrin isoform profile (HP:0003642) | 1.79816049 |
| 87 | Duplicated collecting system (HP:0000081) | 1.79577303 |
| 88 | Severe global developmental delay (HP:0011344) | 1.78885540 |
| 89 | Abnormality of the renal medulla (HP:0100957) | 1.78596028 |
| 90 | Abnormality of the renal collecting system (HP:0004742) | 1.76374839 |
| 91 | Abnormal number of erythroid precursors (HP:0012131) | 1.75996133 |
| 92 | Panhypogammaglobulinemia (HP:0003139) | 1.74508156 |
| 93 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.73425545 |
| 94 | Clubbing of toes (HP:0100760) | 1.71655062 |
| 95 | Constricted visual fields (HP:0001133) | 1.71652896 |
| 96 | Exertional dyspnea (HP:0002875) | 1.71252346 |
| 97 | Abnormality of the astrocytes (HP:0100707) | 1.70434201 |
| 98 | Astrocytoma (HP:0009592) | 1.70434201 |
| 99 | Exercise intolerance (HP:0003546) | 1.70190727 |
| 100 | Chromsome breakage (HP:0040012) | 1.68153518 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK3 | 4.56017316 |
| 2 | TSSK6 | 4.05490579 |
| 3 | EIF2AK1 | 3.77177142 |
| 4 | BUB1 | 3.04027524 |
| 5 | NLK | 2.74121423 |
| 6 | MST4 | 2.67723092 |
| 7 | ZAK | 2.52982828 |
| 8 | VRK2 | 2.44724916 |
| 9 | SRPK1 | 2.34685275 |
| 10 | PBK | 2.30335873 |
| 11 | FRK | 2.20571817 |
| 12 | TLK1 | 2.08919459 |
| 13 | NUAK1 | 1.98822049 |
| 14 | MKNK2 | 1.86855740 |
| 15 | CSNK1G1 | 1.85460475 |
| 16 | PDK2 | 1.83665994 |
| 17 | PLK3 | 1.74417418 |
| 18 | MAPKAPK3 | 1.71431948 |
| 19 | OXSR1 | 1.64965296 |
| 20 | STK39 | 1.56937995 |
| 21 | MKNK1 | 1.55407113 |
| 22 | TRIM28 | 1.55400862 |
| 23 | ADRBK2 | 1.53598396 |
| 24 | NEK1 | 1.52803616 |
| 25 | VRK1 | 1.51239522 |
| 26 | WNK3 | 1.50248715 |
| 27 | GRK1 | 1.46871324 |
| 28 | BRSK2 | 1.42751710 |
| 29 | PLK2 | 1.37102656 |
| 30 | BMPR1B | 1.36436632 |
| 31 | EIF2AK2 | 1.36123953 |
| 32 | WNK4 | 1.35947406 |
| 33 | AKT3 | 1.35049584 |
| 34 | TNIK | 1.33164591 |
| 35 | CSNK1A1L | 1.23790744 |
| 36 | NME1 | 1.23086401 |
| 37 | CAMKK2 | 1.20394312 |
| 38 | CSNK1G3 | 1.12552287 |
| 39 | TAF1 | 1.07727575 |
| 40 | CDK19 | 1.03928033 |
| 41 | MAP4K2 | 1.00635524 |
| 42 | RPS6KB2 | 0.99533205 |
| 43 | ALK | 0.96928653 |
| 44 | BCR | 0.96885012 |
| 45 | PLK1 | 0.94300739 |
| 46 | TEC | 0.89516418 |
| 47 | MAPK13 | 0.83680226 |
| 48 | CSNK1G2 | 0.79961161 |
| 49 | PLK4 | 0.79385636 |
| 50 | ACVR1B | 0.78830685 |
| 51 | TXK | 0.75218155 |
| 52 | SGK2 | 0.75153819 |
| 53 | WEE1 | 0.72983545 |
| 54 | STK16 | 0.72200634 |
| 55 | MAP2K6 | 0.70252360 |
| 56 | TAOK3 | 0.69038798 |
| 57 | MAP3K4 | 0.68636995 |
| 58 | CDC7 | 0.68149728 |
| 59 | STK4 | 0.67225495 |
| 60 | PHKG2 | 0.66272376 |
| 61 | PHKG1 | 0.66272376 |
| 62 | PASK | 0.66047292 |
| 63 | CDK3 | 0.64503919 |
| 64 | IKBKB | 0.63629429 |
| 65 | TIE1 | 0.61782531 |
| 66 | BRD4 | 0.61700048 |
| 67 | MAPKAPK5 | 0.60277999 |
| 68 | STK3 | 0.59857846 |
| 69 | AURKB | 0.59624588 |
| 70 | RPS6KA5 | 0.59320700 |
| 71 | RPS6KA4 | 0.56398882 |
| 72 | MAP2K7 | 0.54636076 |
| 73 | ATR | 0.54316267 |
| 74 | PRKCE | 0.54170798 |
| 75 | TTK | 0.46448610 |
| 76 | STK38L | 0.44834780 |
| 77 | DYRK2 | 0.42820558 |
| 78 | CSNK2A2 | 0.41874751 |
| 79 | CSNK2A1 | 0.41446518 |
| 80 | TGFBR1 | 0.39951127 |
| 81 | PRKCI | 0.39709752 |
| 82 | INSRR | 0.38322593 |
| 83 | DAPK1 | 0.38093725 |
| 84 | PRKCG | 0.37599742 |
| 85 | EPHA3 | 0.36306483 |
| 86 | SIK3 | 0.35836296 |
| 87 | IKBKE | 0.35415568 |
| 88 | NME2 | 0.34424400 |
| 89 | ATM | 0.30224390 |
| 90 | PAK3 | 0.29562053 |
| 91 | CCNB1 | 0.29394015 |
| 92 | CSNK1A1 | 0.29116760 |
| 93 | CSNK1E | 0.29037258 |
| 94 | FGFR1 | 0.23783629 |
| 95 | CHEK1 | 0.23425003 |
| 96 | BRSK1 | 0.22938539 |
| 97 | CAMK2D | 0.21389016 |
| 98 | PAK4 | 0.21312862 |
| 99 | PNCK | 0.20952093 |
| 100 | PINK1 | 0.20307901 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.67553314 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.47602611 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.44865696 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.73946275 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.54233031 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.51237542 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.38978450 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.23915353 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.22419257 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.22154947 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.13877108 |
| 12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.13045390 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.11228589 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.02936393 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.91790424 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.85970789 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.84497057 |
| 18 | Parkinsons disease_Homo sapiens_hsa05012 | 1.84493131 |
| 19 | Spliceosome_Homo sapiens_hsa03040 | 1.78768134 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.78463821 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.77990214 |
| 22 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.74968349 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.64622012 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.56297432 |
| 25 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.49353866 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.49102793 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.48869763 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.34375142 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.33619659 |
| 30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.29565227 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.27898144 |
| 32 | Allograft rejection_Homo sapiens_hsa05330 | 1.27299252 |
| 33 | Phototransduction_Homo sapiens_hsa04744 | 1.27146491 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.26986276 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.25315791 |
| 36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.24089971 |
| 37 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.23770720 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.18281235 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.17421712 |
| 40 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.14734498 |
| 41 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.13207328 |
| 42 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.08625196 |
| 43 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08573176 |
| 44 | Peroxisome_Homo sapiens_hsa04146 | 1.06701312 |
| 45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.04065593 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.00577514 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.92071598 |
| 48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.90961944 |
| 49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.90414749 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.90008750 |
| 51 | Alzheimers disease_Homo sapiens_hsa05010 | 0.89128309 |
| 52 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87809434 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.74448713 |
| 54 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.73318129 |
| 55 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.71632710 |
| 56 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.71371597 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.70728625 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66510223 |
| 59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.66151473 |
| 60 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.65992294 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.65780012 |
| 62 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.63810405 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.63794762 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63614167 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.62690908 |
| 66 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.60508746 |
| 67 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.59552748 |
| 68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.58917974 |
| 69 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57281474 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55513512 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.54939062 |
| 72 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.54223837 |
| 73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.53109320 |
| 74 | Carbon metabolism_Homo sapiens_hsa01200 | 0.51411532 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50861559 |
| 76 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.49827529 |
| 77 | Cell cycle_Homo sapiens_hsa04110 | 0.48963140 |
| 78 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.48722738 |
| 79 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.48319066 |
| 80 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.47735281 |
| 81 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.47689350 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.46880336 |
| 83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46537805 |
| 84 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44572746 |
| 85 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.42063832 |
| 86 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41394305 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.41051332 |
| 88 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40740952 |
| 89 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.39320231 |
| 90 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39207508 |
| 91 | Circadian rhythm_Homo sapiens_hsa04710 | 0.36330847 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34661233 |
| 93 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34513950 |
| 94 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.33720286 |
| 95 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.33598691 |
| 96 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.31395524 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.30730368 |
| 98 | Sulfur relay system_Homo sapiens_hsa04122 | 0.30176005 |
| 99 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.29321621 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.29130613 |

