NPM1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.83030249
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.78382901
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.34501904
4ATP synthesis coupled proton transport (GO:0015986)5.34501904
5DNA deamination (GO:0045006)5.15122622
6proteasome assembly (GO:0043248)4.74763235
7chaperone-mediated protein transport (GO:0072321)4.65347842
8cullin deneddylation (GO:0010388)4.60271518
9rRNA modification (GO:0000154)4.52950820
10protein deneddylation (GO:0000338)4.36689915
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27529820
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.27529820
13NADH dehydrogenase complex assembly (GO:0010257)4.27529820
14protein complex biogenesis (GO:0070271)4.23888800
15pseudouridine synthesis (GO:0001522)4.16261422
16DNA catabolic process, exonucleolytic (GO:0000738)4.08168778
17preassembly of GPI anchor in ER membrane (GO:0016254)4.07571975
18negative regulation of calcium ion transport into cytosol (GO:0010523)4.03543588
19water-soluble vitamin biosynthetic process (GO:0042364)4.01866066
20mitochondrial respiratory chain complex assembly (GO:0033108)4.00838852
21rRNA methylation (GO:0031167)4.00563189
22regulation of cellular amino acid metabolic process (GO:0006521)3.89926830
23ribosome assembly (GO:0042255)3.88711186
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.85344738
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84144956
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83487979
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72972799
28transcription elongation from RNA polymerase I promoter (GO:0006362)3.70851198
29positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.67791441
30DNA replication checkpoint (GO:0000076)3.66042134
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59946347
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56534118
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56534118
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55872439
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55872439
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55872439
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51816554
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51304886
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51304886
40protein neddylation (GO:0045116)3.50273449
41ribosomal large subunit biogenesis (GO:0042273)3.48485306
42negative regulation of ligase activity (GO:0051352)3.47741646
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47741646
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46669917
45cytidine metabolic process (GO:0046087)3.42516051
46cytidine catabolic process (GO:0006216)3.42516051
47cytidine deamination (GO:0009972)3.42516051
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.38003787
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38003787
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37545110
51respiratory electron transport chain (GO:0022904)3.33397149
52rRNA processing (GO:0006364)3.32251677
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.31688988
54electron transport chain (GO:0022900)3.29085704
55protein refolding (GO:0042026)3.26436524
56termination of RNA polymerase I transcription (GO:0006363)3.26213973
57rRNA metabolic process (GO:0016072)3.25505437
58response to pheromone (GO:0019236)3.24888871
59folic acid-containing compound biosynthetic process (GO:0009396)3.24731436
60nucleobase biosynthetic process (GO:0046112)3.22174615
61maturation of SSU-rRNA (GO:0030490)3.20518009
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.19568399
63termination of RNA polymerase III transcription (GO:0006386)3.19568399
64peptidyl-histidine modification (GO:0018202)3.18138955
65protein peptidyl-prolyl isomerization (GO:0000413)3.17873625
66IMP biosynthetic process (GO:0006188)3.16635811
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16442991
68DNA damage response, detection of DNA damage (GO:0042769)3.16372508
69maturation of 5.8S rRNA (GO:0000460)3.14962747
70positive regulation of protein homodimerization activity (GO:0090073)3.14949395
71spliceosomal snRNP assembly (GO:0000387)3.14423108
72tRNA processing (GO:0008033)3.14267122
73ATP biosynthetic process (GO:0006754)3.10557761
74purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08831359
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06884970
76cellular component biogenesis (GO:0044085)3.03449200
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03200384
78regulation of hypersensitivity (GO:0002883)2.97691238
79intracellular protein transmembrane import (GO:0044743)2.94121774
80DNA double-strand break processing (GO:0000729)2.93642579
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93577796
82tRNA metabolic process (GO:0006399)2.93323032
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91785288
84respiratory chain complex IV assembly (GO:0008535)2.88458703
85tRNA modification (GO:0006400)2.88127820
86ribosome biogenesis (GO:0042254)2.85269136
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83449874
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.83077462
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82945194
90isotype switching (GO:0045190)2.82945194
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82945194
92ncRNA metabolic process (GO:0034660)2.81612456
93GTP biosynthetic process (GO:0006183)2.79902024
94ncRNA processing (GO:0034470)2.78572008
95GPI anchor biosynthetic process (GO:0006506)2.78041885
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77484979
97transcription from RNA polymerase I promoter (GO:0006360)2.76835091
98positive regulation of ligase activity (GO:0051351)2.76391384
99negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75666064
100transcription initiation from RNA polymerase I promoter (GO:0006361)2.74691137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.14660422
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.90961636
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.37542842
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.23226165
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57923542
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23797061
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.99096099
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95744504
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.88848757
10VDR_23849224_ChIP-Seq_CD4+_Human2.88542763
11VDR_22108803_ChIP-Seq_LS180_Human2.55742220
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50064493
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47336505
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36941520
15FOXP3_21729870_ChIP-Seq_TREG_Human2.28076888
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.20884737
17ELK1_19687146_ChIP-ChIP_HELA_Human2.17705545
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.14218731
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11308951
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06457570
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02901451
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00414070
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99718036
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89609003
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87630500
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85771268
27EWS_26573619_Chip-Seq_HEK293_Human1.80140080
28ZNF274_21170338_ChIP-Seq_K562_Hela1.79505497
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69659379
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68041311
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67551156
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66991893
33DCP1A_22483619_ChIP-Seq_HELA_Human1.65219261
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65182501
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64721155
36TTF2_22483619_ChIP-Seq_HELA_Human1.59104269
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55555999
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.54970901
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54809248
40GABP_19822575_ChIP-Seq_HepG2_Human1.54530888
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53554491
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.51705018
43MYC_18940864_ChIP-ChIP_HL60_Human1.48206973
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34494915
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34480075
46GATA3_26560356_Chip-Seq_TH2_Human1.30039387
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.29464171
48E2F7_22180533_ChIP-Seq_HELA_Human1.28757442
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28706139
50CIITA_25753668_ChIP-Seq_RAJI_Human1.28387249
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26616698
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24404106
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23482055
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23482055
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22320745
56NANOG_19829295_ChIP-Seq_ESCs_Human1.21672467
57SOX2_19829295_ChIP-Seq_ESCs_Human1.21672467
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21432896
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.20280162
60ER_23166858_ChIP-Seq_MCF-7_Human1.18394622
61TP53_22573176_ChIP-Seq_HFKS_Human1.18318533
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16988395
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15900362
64XRN2_22483619_ChIP-Seq_HELA_Human1.13569374
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12909310
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12775843
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.09287675
68P300_19829295_ChIP-Seq_ESCs_Human1.08942380
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05266889
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04332838
71FUS_26573619_Chip-Seq_HEK293_Human1.03893888
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03653577
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.01210735
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01156790
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00213534
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99254855
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99250722
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97609116
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.97512084
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96563179
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.96069743
82NCOR_22424771_ChIP-Seq_293T_Human0.95376601
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95201858
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94604469
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94228059
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93971838
87BP1_19119308_ChIP-ChIP_Hs578T_Human0.93331415
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92459006
89ERG_20517297_ChIP-Seq_VCAP_Human0.92040642
90IRF1_19129219_ChIP-ChIP_H3396_Human0.91482598
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90708003
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90448143
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89540860
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88374652
95TAF15_26573619_Chip-Seq_HEK293_Human0.88263941
96IGF1R_20145208_ChIP-Seq_DFB_Human0.88157889
97P300_18555785_Chip-Seq_ESCs_Mouse0.87869461
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87400484
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85603130
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85312188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.49868081
2MP0002102_abnormal_ear_morphology3.99119444
3MP0001835_abnormal_antigen_presentation3.34387528
4MP0008057_abnormal_DNA_replication3.15467233
5MP0003878_abnormal_ear_physiology2.74466542
6MP0005377_hearing/vestibular/ear_phenot2.74466542
7MP0000685_abnormal_immune_system2.59002360
8MP0005671_abnormal_response_to2.48072469
9MP0009785_altered_susceptibility_to2.36411330
10MP0006292_abnormal_olfactory_placode2.23867712
11MP0008058_abnormal_DNA_repair2.20334225
12MP0003718_maternal_effect2.18489505
13MP0008872_abnormal_physiological_respon2.13579561
14MP0003786_premature_aging2.07691755
15MP0005379_endocrine/exocrine_gland_phen1.99974063
16MP0005084_abnormal_gallbladder_morpholo1.99315188
17MP0010094_abnormal_chromosome_stability1.98900869
18MP0000372_irregular_coat_pigmentation1.97286427
19MP0009333_abnormal_splenocyte_physiolog1.94986660
20MP0008877_abnormal_DNA_methylation1.92758213
21MP0002006_tumorigenesis1.92749513
22MP0002166_altered_tumor_susceptibility1.88223192
23MP0005645_abnormal_hypothalamus_physiol1.85216599
24MP0006036_abnormal_mitochondrial_physio1.84064971
25MP0001800_abnormal_humoral_immune1.81787624
26MP0003950_abnormal_plasma_membrane1.78448244
27MP0001790_abnormal_immune_system1.69379439
28MP0005387_immune_system_phenotype1.69379439
29MP0005075_abnormal_melanosome_morpholog1.67666515
30MP0002163_abnormal_gland_morphology1.63725238
31MP0004957_abnormal_blastocyst_morpholog1.61413982
32MP0004145_abnormal_muscle_electrophysio1.58820191
33MP0006035_abnormal_mitochondrial_morpho1.58229391
34MP0003806_abnormal_nucleotide_metabolis1.57967216
35MP0003646_muscle_fatigue1.54347605
36MP0001986_abnormal_taste_sensitivity1.52954072
37MP0002138_abnormal_hepatobiliary_system1.51733815
38MP0008007_abnormal_cellular_replicative1.50787879
39MP0003186_abnormal_redox_activity1.49284256
40MP0002277_abnormal_respiratory_mucosa1.40354641
41MP0002148_abnormal_hypersensitivity_rea1.37181274
42MP0003866_abnormal_defecation1.35598228
43MP0003763_abnormal_thymus_physiology1.31256037
44MP0002736_abnormal_nociception_after1.21367074
45MP0002837_dystrophic_cardiac_calcinosis1.19832967
46MP0002396_abnormal_hematopoietic_system1.19800488
47MP0003724_increased_susceptibility_to1.19622834
48MP0005551_abnormal_eye_electrophysiolog1.17643044
49MP0001905_abnormal_dopamine_level1.17524133
50MP0008995_early_reproductive_senescence1.16627271
51MP0008875_abnormal_xenobiotic_pharmacok1.15651877
52MP0004142_abnormal_muscle_tone1.15223847
53MP0002723_abnormal_immune_serum1.14741258
54MP0001968_abnormal_touch/_nociception1.14244412
55MP0008775_abnormal_heart_ventricle1.11300927
56MP0005167_abnormal_blood-brain_barrier1.11216795
57MP0002452_abnormal_antigen_presenting1.10815604
58MP0005636_abnormal_mineral_homeostasis1.09968491
59MP0009764_decreased_sensitivity_to1.08009710
60MP0003195_calcinosis1.07916593
61MP0001501_abnormal_sleep_pattern1.04883354
62MP0003693_abnormal_embryo_hatching1.01808036
63MP0004381_abnormal_hair_follicle1.00990368
64MP0003077_abnormal_cell_cycle1.00639223
65MP0001853_heart_inflammation0.97048516
66MP0002420_abnormal_adaptive_immunity0.95318407
67MP0005410_abnormal_fertilization0.93293701
68MP0001819_abnormal_immune_cell0.92235745
69MP0001919_abnormal_reproductive_system0.91744148
70MP0005085_abnormal_gallbladder_physiolo0.90751324
71MP0003111_abnormal_nucleus_morphology0.89544631
72MP0006072_abnormal_retinal_apoptosis0.89043471
73MP0009745_abnormal_behavioral_response0.86815508
74MP0005000_abnormal_immune_tolerance0.86191371
75MP0002398_abnormal_bone_marrow0.85850606
76MP0005360_urolithiasis0.84741379
77MP0000703_abnormal_thymus_morphology0.82834756
78MP0002938_white_spotting0.81335983
79MP0000569_abnormal_digit_pigmentation0.81204276
80MP0000689_abnormal_spleen_morphology0.80415183
81MP0005165_increased_susceptibility_to0.80019981
82MP0000716_abnormal_immune_system0.79295446
83MP0005408_hypopigmentation0.78892318
84MP0005025_abnormal_response_to0.78644959
85MP0003045_fibrosis0.78254881
86MP0005395_other_phenotype0.78087463
87MP0001485_abnormal_pinna_reflex0.76518446
88MP0003567_abnormal_fetal_cardiomyocyte0.75798140
89MP0002751_abnormal_autonomic_nervous0.75547978
90MP0002095_abnormal_skin_pigmentation0.72502767
91MP0001765_abnormal_ion_homeostasis0.71320062
92MP0010155_abnormal_intestine_physiology0.71255300
93MP0008873_increased_physiological_sensi0.70249130
94MP0002429_abnormal_blood_cell0.69747765
95MP0009697_abnormal_copulation0.69520403
96MP0004215_abnormal_myocardial_fiber0.68964268
97MP0002405_respiratory_system_inflammati0.68130347
98MP0004885_abnormal_endolymph0.66910586
99MP0002272_abnormal_nervous_system0.65898634
100MP0005646_abnormal_pituitary_gland0.65232802

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57038458
2Increased CSF lactate (HP:0002490)4.38522253
3Mitochondrial inheritance (HP:0001427)4.17342268
4Abnormality of the pons (HP:0007361)4.07455334
5Increased hepatocellular lipid droplets (HP:0006565)3.94431775
6Lipid accumulation in hepatocytes (HP:0006561)3.92039125
7Abnormal mitochondria in muscle tissue (HP:0008316)3.91571871
8Acute encephalopathy (HP:0006846)3.83941890
9Progressive macrocephaly (HP:0004481)3.71326078
10Increased serum lactate (HP:0002151)3.50383866
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.37770780
12Hypoplasia of the pons (HP:0012110)3.36395536
13IgG deficiency (HP:0004315)3.28745067
14Retrobulbar optic neuritis (HP:0100654)3.22165700
15Optic neuritis (HP:0100653)3.22165700
16Hepatocellular necrosis (HP:0001404)3.21343018
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10659532
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10659532
193-Methylglutaconic aciduria (HP:0003535)3.07472601
20Exertional dyspnea (HP:0002875)3.04184145
21Cerebral edema (HP:0002181)3.02426925
22Increased serum pyruvate (HP:0003542)3.00696197
23Type II lissencephaly (HP:0007260)3.00450151
24Large for gestational age (HP:0001520)2.95647235
25Testicular atrophy (HP:0000029)2.86742768
26Hepatic necrosis (HP:0002605)2.80896480
27Renal Fanconi syndrome (HP:0001994)2.77039750
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76622550
29Abnormality of glycolysis (HP:0004366)2.66813704
30Pendular nystagmus (HP:0012043)2.66513937
31Chronic sinusitis (HP:0011109)2.62577906
32Optic disc pallor (HP:0000543)2.62430126
33Exercise intolerance (HP:0003546)2.60071200
34Increased intramyocellular lipid droplets (HP:0012240)2.59118081
35Elevated erythrocyte sedimentation rate (HP:0003565)2.58894708
36Lactic acidosis (HP:0003128)2.58828509
37Orchitis (HP:0100796)2.48969010
38Pulmonary infiltrates (HP:0002113)2.48723251
39Abnormality of alanine metabolism (HP:0010916)2.35936718
40Hyperalaninemia (HP:0003348)2.35936718
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35936718
42Abnormality of the labia minora (HP:0012880)2.34276656
43Respiratory failure (HP:0002878)2.29646946
44Increased muscle lipid content (HP:0009058)2.28720161
45Keratoconjunctivitis sicca (HP:0001097)2.27739836
46Myositis (HP:0100614)2.26345809
47Duplicated collecting system (HP:0000081)2.24419930
48Methylmalonic aciduria (HP:0012120)2.23086168
49Congenital stationary night blindness (HP:0007642)2.22921504
50Azoospermia (HP:0000027)2.21890931
51Abolished electroretinogram (ERG) (HP:0000550)2.21476931
52Central scotoma (HP:0000603)2.19299341
53Cleft eyelid (HP:0000625)2.18079726
54Cerebral hypomyelination (HP:0006808)2.16172831
55Methylmalonic acidemia (HP:0002912)2.16116389
56Keratoconjunctivitis (HP:0001096)2.12249564
57Chronic bronchitis (HP:0004469)2.10961331
58Leukodystrophy (HP:0002415)2.09649184
59Abnormality of methionine metabolism (HP:0010901)2.09377895
60Abnormality of the renal collecting system (HP:0004742)2.05399821
61Opisthotonus (HP:0002179)2.05112209
62Lethargy (HP:0001254)2.04264130
63Macrocytic anemia (HP:0001972)2.03992800
64Retinal dysplasia (HP:0007973)2.03829824
65Abnormality of midbrain morphology (HP:0002418)2.02588293
66Molar tooth sign on MRI (HP:0002419)2.02588293
67Congenital, generalized hypertrichosis (HP:0004540)2.02149862
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01711707
69Hypomagnesemia (HP:0002917)2.01497107
70CNS demyelination (HP:0007305)1.99712341
71Pancreatic cysts (HP:0001737)1.99133434
72Premature ovarian failure (HP:0008209)1.98453423
73Constricted visual fields (HP:0001133)1.97589373
74Hypoproteinemia (HP:0003075)1.97338959
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.94635300
76Absent/shortened dynein arms (HP:0200106)1.94635300
77Abnormal spermatogenesis (HP:0008669)1.93869454
78Abnormal number of erythroid precursors (HP:0012131)1.92972938
79Type I transferrin isoform profile (HP:0003642)1.90384248
80Stomatitis (HP:0010280)1.89945553
81Abnormality of urine glucose concentration (HP:0011016)1.89120109
82Glycosuria (HP:0003076)1.89120109
83Tetany (HP:0001281)1.89076461
84Bronchitis (HP:0012387)1.88025122
85Abnormality of cells of the erythroid lineage (HP:0012130)1.86231159
86Respiratory difficulties (HP:0002880)1.84801035
87Abnormality of T cells (HP:0002843)1.84320869
88B lymphocytopenia (HP:0010976)1.84113380
89Abnormality of B cell number (HP:0010975)1.83906697
90Parakeratosis (HP:0001036)1.83383132
91Reduced antithrombin III activity (HP:0001976)1.82510330
92Encephalitis (HP:0002383)1.81812207
93Megaloblastic anemia (HP:0001889)1.81709854
94Keratoconus (HP:0000563)1.81071740
95Increased corneal curvature (HP:0100692)1.81071740
96Abnormal respiratory motile cilium morphology (HP:0005938)1.80736355
97Abnormal respiratory epithelium morphology (HP:0012253)1.80736355
98Abnormal albumin level (HP:0012116)1.80221069
99Hypoalbuminemia (HP:0003073)1.80221069
100Polyneuropathy (HP:0001271)1.80128308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.63610323
2MST44.09039029
3VRK23.58335520
4EIF2AK13.53330580
5TLK13.52828589
6TXK3.30671690
7BUB12.97907490
8EIF2AK32.80389843
9TAF12.49958900
10ZAK2.34305470
11NEK12.27325622
12MAP4K22.17808359
13NUAK12.17383524
14SRPK11.96054483
15PLK31.82272459
16SCYL21.74217297
17GRK11.72841256
18MAP2K61.65705399
19VRK11.61927102
20ALK1.59595564
21PASK1.52686579
22ADRBK21.34507082
23FRK1.34409871
24MAP3K121.31152436
25MKNK21.28710051
26BMPR21.28176186
27KIT1.27163752
28STK391.18917327
29SMG11.18230695
30CDC71.16512259
31EIF2AK21.15713702
32INSRR1.10054611
33DAPK11.03554731
34WNK41.02298925
35DYRK21.00891357
36MKNK11.00022777
37FLT30.99618605
38PBK0.98287393
39DAPK20.97936551
40EPHA30.97352599
41STK38L0.96097092
42MYLK0.95943617
43TAOK30.95056425
44PLK40.90898818
45TIE10.88041006
46NME10.86282916
47ERBB30.81634107
48OXSR10.81589114
49TGFBR10.81117780
50BCKDK0.80366645
51NME20.79145413
52EPHA40.78052416
53ACVR1B0.71977552
54IKBKB0.69658327
55BMPR1B0.65057868
56AURKB0.60679550
57PDK20.60101357
58CDK80.59574066
59MAP4K10.59166245
60CLK10.56144616
61TYK20.53223253
62DAPK30.52844473
63ATR0.52101276
64STK160.51658255
65TRIM280.50230519
66WNK30.49399967
67RPS6KA40.48985443
68GRK50.47232782
69ILK0.43822809
70PLK20.43677626
71CSNK2A20.42044349
72TEC0.41969880
73CSNK2A10.41331133
74PLK10.40516140
75FGFR10.38969945
76STK30.38934899
77ITK0.36651053
78RPS6KA50.35933699
79MAP3K140.35429297
80PHKG10.34837415
81PHKG20.34837415
82CSNK1A1L0.34736031
83MAPKAPK50.32094369
84FGFR30.31371945
85JAK30.31295548
86CSNK1G30.31289225
87AKT30.31240316
88CCNB10.31126932
89FGFR40.30711167
90WEE10.30550596
91TTK0.28519005
92JAK10.28350829
93CSNK1E0.28170143
94PRKCE0.28129824
95PIK3CG0.27958868
96SYK0.27172021
97CHEK20.26771939
98CHUK0.25620038
99IRAK10.24714517
100IGF1R0.23038081

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.03231434
2Oxidative phosphorylation_Homo sapiens_hsa001903.21049621
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19849926
4Asthma_Homo sapiens_hsa053102.96557452
5Protein export_Homo sapiens_hsa030602.76829988
6Parkinsons disease_Homo sapiens_hsa050122.70017583
7Ribosome_Homo sapiens_hsa030102.56406624
8One carbon pool by folate_Homo sapiens_hsa006702.52917880
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51279572
10RNA polymerase_Homo sapiens_hsa030202.31319831
11Homologous recombination_Homo sapiens_hsa034402.19026090
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.06785814
13Allograft rejection_Homo sapiens_hsa053302.00944693
14Autoimmune thyroid disease_Homo sapiens_hsa053201.93547653
15Huntingtons disease_Homo sapiens_hsa050161.93160194
16Basal transcription factors_Homo sapiens_hsa030221.87901143
17Antigen processing and presentation_Homo sapiens_hsa046121.86231763
18Type I diabetes mellitus_Homo sapiens_hsa049401.83879041
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83017677
20Graft-versus-host disease_Homo sapiens_hsa053321.76744574
21RNA degradation_Homo sapiens_hsa030181.73150363
22RNA transport_Homo sapiens_hsa030131.63818285
23Alzheimers disease_Homo sapiens_hsa050101.61455302
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55888935
25Spliceosome_Homo sapiens_hsa030401.54524561
26DNA replication_Homo sapiens_hsa030301.50590192
27Base excision repair_Homo sapiens_hsa034101.46263593
28Nucleotide excision repair_Homo sapiens_hsa034201.40520805
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.39479839
30Pyrimidine metabolism_Homo sapiens_hsa002401.37262161
31Non-homologous end-joining_Homo sapiens_hsa034501.36552409
32Mismatch repair_Homo sapiens_hsa034301.34326662
33Propanoate metabolism_Homo sapiens_hsa006401.34127921
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29373470
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25693261
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20208951
37Primary immunodeficiency_Homo sapiens_hsa053401.17750353
38Purine metabolism_Homo sapiens_hsa002301.09717656
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02990892
40Fanconi anemia pathway_Homo sapiens_hsa034600.99351218
41Phototransduction_Homo sapiens_hsa047440.97341885
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94419837
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92182241
44Pyruvate metabolism_Homo sapiens_hsa006200.90237363
45Linoleic acid metabolism_Homo sapiens_hsa005910.90186398
46Rheumatoid arthritis_Homo sapiens_hsa053230.89759921
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85235849
48Collecting duct acid secretion_Homo sapiens_hsa049660.85225948
49Sulfur relay system_Homo sapiens_hsa041220.84591902
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82614272
51Vitamin B6 metabolism_Homo sapiens_hsa007500.81790047
52Cardiac muscle contraction_Homo sapiens_hsa042600.80874863
53Caffeine metabolism_Homo sapiens_hsa002320.80710945
54Epstein-Barr virus infection_Homo sapiens_hsa051690.75485378
55Steroid biosynthesis_Homo sapiens_hsa001000.67386813
56Selenocompound metabolism_Homo sapiens_hsa004500.65810845
57Viral myocarditis_Homo sapiens_hsa054160.63430772
58Metabolic pathways_Homo sapiens_hsa011000.62430564
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61525770
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60449972
61Nitrogen metabolism_Homo sapiens_hsa009100.59349485
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59305462
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.57766936
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57072559
65Tryptophan metabolism_Homo sapiens_hsa003800.51558537
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51344530
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50318702
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49393026
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49363836
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48353700
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46466295
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46081914
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.43504643
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43501714
75Hematopoietic cell lineage_Homo sapiens_hsa046400.43330307
76Butanoate metabolism_Homo sapiens_hsa006500.42985643
77Glutathione metabolism_Homo sapiens_hsa004800.42785135
78Folate biosynthesis_Homo sapiens_hsa007900.42601732
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41598489
80Staphylococcus aureus infection_Homo sapiens_hsa051500.40609197
81Systemic lupus erythematosus_Homo sapiens_hsa053220.39186066
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37007105
83Peroxisome_Homo sapiens_hsa041460.36431085
84Measles_Homo sapiens_hsa051620.35189533
85Herpes simplex infection_Homo sapiens_hsa051680.34789094
86Ether lipid metabolism_Homo sapiens_hsa005650.33566095
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32973620
88mRNA surveillance pathway_Homo sapiens_hsa030150.31275374
89Arginine and proline metabolism_Homo sapiens_hsa003300.30815689
90beta-Alanine metabolism_Homo sapiens_hsa004100.29591748
91Biosynthesis of amino acids_Homo sapiens_hsa012300.28985674
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.28907624
93Regulation of autophagy_Homo sapiens_hsa041400.27984165
94Carbon metabolism_Homo sapiens_hsa012000.27149675
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.26210192
96Fat digestion and absorption_Homo sapiens_hsa049750.26205672
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.24409678
98Chemical carcinogenesis_Homo sapiens_hsa052040.24033061
99Retinol metabolism_Homo sapiens_hsa008300.22985348
100Legionellosis_Homo sapiens_hsa051340.22496321

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