

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.83030249 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.78382901 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.34501904 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.34501904 |
| 5 | DNA deamination (GO:0045006) | 5.15122622 |
| 6 | proteasome assembly (GO:0043248) | 4.74763235 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.65347842 |
| 8 | cullin deneddylation (GO:0010388) | 4.60271518 |
| 9 | rRNA modification (GO:0000154) | 4.52950820 |
| 10 | protein deneddylation (GO:0000338) | 4.36689915 |
| 11 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.27529820 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.27529820 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 4.27529820 |
| 14 | protein complex biogenesis (GO:0070271) | 4.23888800 |
| 15 | pseudouridine synthesis (GO:0001522) | 4.16261422 |
| 16 | DNA catabolic process, exonucleolytic (GO:0000738) | 4.08168778 |
| 17 | preassembly of GPI anchor in ER membrane (GO:0016254) | 4.07571975 |
| 18 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 4.03543588 |
| 19 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.01866066 |
| 20 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.00838852 |
| 21 | rRNA methylation (GO:0031167) | 4.00563189 |
| 22 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.89926830 |
| 23 | ribosome assembly (GO:0042255) | 3.88711186 |
| 24 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.85344738 |
| 25 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.84144956 |
| 26 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.83487979 |
| 27 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.72972799 |
| 28 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.70851198 |
| 29 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.67791441 |
| 30 | DNA replication checkpoint (GO:0000076) | 3.66042134 |
| 31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.59946347 |
| 32 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.56534118 |
| 33 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.56534118 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.55872439 |
| 35 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.55872439 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.55872439 |
| 37 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.51816554 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51304886 |
| 39 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51304886 |
| 40 | protein neddylation (GO:0045116) | 3.50273449 |
| 41 | ribosomal large subunit biogenesis (GO:0042273) | 3.48485306 |
| 42 | negative regulation of ligase activity (GO:0051352) | 3.47741646 |
| 43 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.47741646 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.46669917 |
| 45 | cytidine metabolic process (GO:0046087) | 3.42516051 |
| 46 | cytidine catabolic process (GO:0006216) | 3.42516051 |
| 47 | cytidine deamination (GO:0009972) | 3.42516051 |
| 48 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.38003787 |
| 49 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.38003787 |
| 50 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.37545110 |
| 51 | respiratory electron transport chain (GO:0022904) | 3.33397149 |
| 52 | rRNA processing (GO:0006364) | 3.32251677 |
| 53 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.31688988 |
| 54 | electron transport chain (GO:0022900) | 3.29085704 |
| 55 | protein refolding (GO:0042026) | 3.26436524 |
| 56 | termination of RNA polymerase I transcription (GO:0006363) | 3.26213973 |
| 57 | rRNA metabolic process (GO:0016072) | 3.25505437 |
| 58 | response to pheromone (GO:0019236) | 3.24888871 |
| 59 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.24731436 |
| 60 | nucleobase biosynthetic process (GO:0046112) | 3.22174615 |
| 61 | maturation of SSU-rRNA (GO:0030490) | 3.20518009 |
| 62 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.19568399 |
| 63 | termination of RNA polymerase III transcription (GO:0006386) | 3.19568399 |
| 64 | peptidyl-histidine modification (GO:0018202) | 3.18138955 |
| 65 | protein peptidyl-prolyl isomerization (GO:0000413) | 3.17873625 |
| 66 | IMP biosynthetic process (GO:0006188) | 3.16635811 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.16442991 |
| 68 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16372508 |
| 69 | maturation of 5.8S rRNA (GO:0000460) | 3.14962747 |
| 70 | positive regulation of protein homodimerization activity (GO:0090073) | 3.14949395 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 3.14423108 |
| 72 | tRNA processing (GO:0008033) | 3.14267122 |
| 73 | ATP biosynthetic process (GO:0006754) | 3.10557761 |
| 74 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.08831359 |
| 75 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.06884970 |
| 76 | cellular component biogenesis (GO:0044085) | 3.03449200 |
| 77 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.03200384 |
| 78 | regulation of hypersensitivity (GO:0002883) | 2.97691238 |
| 79 | intracellular protein transmembrane import (GO:0044743) | 2.94121774 |
| 80 | DNA double-strand break processing (GO:0000729) | 2.93642579 |
| 81 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.93577796 |
| 82 | tRNA metabolic process (GO:0006399) | 2.93323032 |
| 83 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.91785288 |
| 84 | respiratory chain complex IV assembly (GO:0008535) | 2.88458703 |
| 85 | tRNA modification (GO:0006400) | 2.88127820 |
| 86 | ribosome biogenesis (GO:0042254) | 2.85269136 |
| 87 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.83449874 |
| 88 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.83077462 |
| 89 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.82945194 |
| 90 | isotype switching (GO:0045190) | 2.82945194 |
| 91 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.82945194 |
| 92 | ncRNA metabolic process (GO:0034660) | 2.81612456 |
| 93 | GTP biosynthetic process (GO:0006183) | 2.79902024 |
| 94 | ncRNA processing (GO:0034470) | 2.78572008 |
| 95 | GPI anchor biosynthetic process (GO:0006506) | 2.78041885 |
| 96 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.77484979 |
| 97 | transcription from RNA polymerase I promoter (GO:0006360) | 2.76835091 |
| 98 | positive regulation of ligase activity (GO:0051351) | 2.76391384 |
| 99 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.75666064 |
| 100 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.74691137 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.14660422 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.90961636 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.37542842 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.23226165 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.57923542 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.23797061 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.99096099 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.95744504 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.88848757 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.88542763 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.55742220 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.50064493 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.47336505 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.36941520 |
| 15 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.28076888 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.20884737 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.17705545 |
| 18 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.14218731 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.11308951 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.06457570 |
| 21 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.02901451 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.00414070 |
| 23 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.99718036 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.89609003 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.87630500 |
| 26 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.85771268 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.80140080 |
| 28 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.79505497 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69659379 |
| 30 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.68041311 |
| 31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.67551156 |
| 32 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.66991893 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.65219261 |
| 34 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.65182501 |
| 35 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.64721155 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.59104269 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.55555999 |
| 38 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.54970901 |
| 39 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54809248 |
| 40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54530888 |
| 41 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.53554491 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.51705018 |
| 43 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.48206973 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.34494915 |
| 45 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.34480075 |
| 46 | GATA3_26560356_Chip-Seq_TH2_Human | 1.30039387 |
| 47 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.29464171 |
| 48 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.28757442 |
| 49 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.28706139 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.28387249 |
| 51 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.26616698 |
| 52 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24404106 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23482055 |
| 54 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23482055 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22320745 |
| 56 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.21672467 |
| 57 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.21672467 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.21432896 |
| 59 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20280162 |
| 60 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.18394622 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.18318533 |
| 62 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16988395 |
| 63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.15900362 |
| 64 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.13569374 |
| 65 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12909310 |
| 66 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.12775843 |
| 67 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.09287675 |
| 68 | P300_19829295_ChIP-Seq_ESCs_Human | 1.08942380 |
| 69 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05266889 |
| 70 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.04332838 |
| 71 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03893888 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03653577 |
| 73 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.01210735 |
| 74 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.01156790 |
| 75 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.00213534 |
| 76 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.99254855 |
| 77 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.99250722 |
| 78 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97609116 |
| 79 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.97512084 |
| 80 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.96563179 |
| 81 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.96069743 |
| 82 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95376601 |
| 83 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.95201858 |
| 84 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94604469 |
| 85 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.94228059 |
| 86 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.93971838 |
| 87 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.93331415 |
| 88 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92459006 |
| 89 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.92040642 |
| 90 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.91482598 |
| 91 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.90708003 |
| 92 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90448143 |
| 93 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.89540860 |
| 94 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.88374652 |
| 95 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.88263941 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.88157889 |
| 97 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.87869461 |
| 98 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.87400484 |
| 99 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.85603130 |
| 100 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.85312188 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 4.49868081 |
| 2 | MP0002102_abnormal_ear_morphology | 3.99119444 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.34387528 |
| 4 | MP0008057_abnormal_DNA_replication | 3.15467233 |
| 5 | MP0003878_abnormal_ear_physiology | 2.74466542 |
| 6 | MP0005377_hearing/vestibular/ear_phenot | 2.74466542 |
| 7 | MP0000685_abnormal_immune_system | 2.59002360 |
| 8 | MP0005671_abnormal_response_to | 2.48072469 |
| 9 | MP0009785_altered_susceptibility_to | 2.36411330 |
| 10 | MP0006292_abnormal_olfactory_placode | 2.23867712 |
| 11 | MP0008058_abnormal_DNA_repair | 2.20334225 |
| 12 | MP0003718_maternal_effect | 2.18489505 |
| 13 | MP0008872_abnormal_physiological_respon | 2.13579561 |
| 14 | MP0003786_premature_aging | 2.07691755 |
| 15 | MP0005379_endocrine/exocrine_gland_phen | 1.99974063 |
| 16 | MP0005084_abnormal_gallbladder_morpholo | 1.99315188 |
| 17 | MP0010094_abnormal_chromosome_stability | 1.98900869 |
| 18 | MP0000372_irregular_coat_pigmentation | 1.97286427 |
| 19 | MP0009333_abnormal_splenocyte_physiolog | 1.94986660 |
| 20 | MP0008877_abnormal_DNA_methylation | 1.92758213 |
| 21 | MP0002006_tumorigenesis | 1.92749513 |
| 22 | MP0002166_altered_tumor_susceptibility | 1.88223192 |
| 23 | MP0005645_abnormal_hypothalamus_physiol | 1.85216599 |
| 24 | MP0006036_abnormal_mitochondrial_physio | 1.84064971 |
| 25 | MP0001800_abnormal_humoral_immune | 1.81787624 |
| 26 | MP0003950_abnormal_plasma_membrane | 1.78448244 |
| 27 | MP0001790_abnormal_immune_system | 1.69379439 |
| 28 | MP0005387_immune_system_phenotype | 1.69379439 |
| 29 | MP0005075_abnormal_melanosome_morpholog | 1.67666515 |
| 30 | MP0002163_abnormal_gland_morphology | 1.63725238 |
| 31 | MP0004957_abnormal_blastocyst_morpholog | 1.61413982 |
| 32 | MP0004145_abnormal_muscle_electrophysio | 1.58820191 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.58229391 |
| 34 | MP0003806_abnormal_nucleotide_metabolis | 1.57967216 |
| 35 | MP0003646_muscle_fatigue | 1.54347605 |
| 36 | MP0001986_abnormal_taste_sensitivity | 1.52954072 |
| 37 | MP0002138_abnormal_hepatobiliary_system | 1.51733815 |
| 38 | MP0008007_abnormal_cellular_replicative | 1.50787879 |
| 39 | MP0003186_abnormal_redox_activity | 1.49284256 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.40354641 |
| 41 | MP0002148_abnormal_hypersensitivity_rea | 1.37181274 |
| 42 | MP0003866_abnormal_defecation | 1.35598228 |
| 43 | MP0003763_abnormal_thymus_physiology | 1.31256037 |
| 44 | MP0002736_abnormal_nociception_after | 1.21367074 |
| 45 | MP0002837_dystrophic_cardiac_calcinosis | 1.19832967 |
| 46 | MP0002396_abnormal_hematopoietic_system | 1.19800488 |
| 47 | MP0003724_increased_susceptibility_to | 1.19622834 |
| 48 | MP0005551_abnormal_eye_electrophysiolog | 1.17643044 |
| 49 | MP0001905_abnormal_dopamine_level | 1.17524133 |
| 50 | MP0008995_early_reproductive_senescence | 1.16627271 |
| 51 | MP0008875_abnormal_xenobiotic_pharmacok | 1.15651877 |
| 52 | MP0004142_abnormal_muscle_tone | 1.15223847 |
| 53 | MP0002723_abnormal_immune_serum | 1.14741258 |
| 54 | MP0001968_abnormal_touch/_nociception | 1.14244412 |
| 55 | MP0008775_abnormal_heart_ventricle | 1.11300927 |
| 56 | MP0005167_abnormal_blood-brain_barrier | 1.11216795 |
| 57 | MP0002452_abnormal_antigen_presenting | 1.10815604 |
| 58 | MP0005636_abnormal_mineral_homeostasis | 1.09968491 |
| 59 | MP0009764_decreased_sensitivity_to | 1.08009710 |
| 60 | MP0003195_calcinosis | 1.07916593 |
| 61 | MP0001501_abnormal_sleep_pattern | 1.04883354 |
| 62 | MP0003693_abnormal_embryo_hatching | 1.01808036 |
| 63 | MP0004381_abnormal_hair_follicle | 1.00990368 |
| 64 | MP0003077_abnormal_cell_cycle | 1.00639223 |
| 65 | MP0001853_heart_inflammation | 0.97048516 |
| 66 | MP0002420_abnormal_adaptive_immunity | 0.95318407 |
| 67 | MP0005410_abnormal_fertilization | 0.93293701 |
| 68 | MP0001819_abnormal_immune_cell | 0.92235745 |
| 69 | MP0001919_abnormal_reproductive_system | 0.91744148 |
| 70 | MP0005085_abnormal_gallbladder_physiolo | 0.90751324 |
| 71 | MP0003111_abnormal_nucleus_morphology | 0.89544631 |
| 72 | MP0006072_abnormal_retinal_apoptosis | 0.89043471 |
| 73 | MP0009745_abnormal_behavioral_response | 0.86815508 |
| 74 | MP0005000_abnormal_immune_tolerance | 0.86191371 |
| 75 | MP0002398_abnormal_bone_marrow | 0.85850606 |
| 76 | MP0005360_urolithiasis | 0.84741379 |
| 77 | MP0000703_abnormal_thymus_morphology | 0.82834756 |
| 78 | MP0002938_white_spotting | 0.81335983 |
| 79 | MP0000569_abnormal_digit_pigmentation | 0.81204276 |
| 80 | MP0000689_abnormal_spleen_morphology | 0.80415183 |
| 81 | MP0005165_increased_susceptibility_to | 0.80019981 |
| 82 | MP0000716_abnormal_immune_system | 0.79295446 |
| 83 | MP0005408_hypopigmentation | 0.78892318 |
| 84 | MP0005025_abnormal_response_to | 0.78644959 |
| 85 | MP0003045_fibrosis | 0.78254881 |
| 86 | MP0005395_other_phenotype | 0.78087463 |
| 87 | MP0001485_abnormal_pinna_reflex | 0.76518446 |
| 88 | MP0003567_abnormal_fetal_cardiomyocyte | 0.75798140 |
| 89 | MP0002751_abnormal_autonomic_nervous | 0.75547978 |
| 90 | MP0002095_abnormal_skin_pigmentation | 0.72502767 |
| 91 | MP0001765_abnormal_ion_homeostasis | 0.71320062 |
| 92 | MP0010155_abnormal_intestine_physiology | 0.71255300 |
| 93 | MP0008873_increased_physiological_sensi | 0.70249130 |
| 94 | MP0002429_abnormal_blood_cell | 0.69747765 |
| 95 | MP0009697_abnormal_copulation | 0.69520403 |
| 96 | MP0004215_abnormal_myocardial_fiber | 0.68964268 |
| 97 | MP0002405_respiratory_system_inflammati | 0.68130347 |
| 98 | MP0004885_abnormal_endolymph | 0.66910586 |
| 99 | MP0002272_abnormal_nervous_system | 0.65898634 |
| 100 | MP0005646_abnormal_pituitary_gland | 0.65232802 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.57038458 |
| 2 | Increased CSF lactate (HP:0002490) | 4.38522253 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.17342268 |
| 4 | Abnormality of the pons (HP:0007361) | 4.07455334 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 3.94431775 |
| 6 | Lipid accumulation in hepatocytes (HP:0006561) | 3.92039125 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.91571871 |
| 8 | Acute encephalopathy (HP:0006846) | 3.83941890 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.71326078 |
| 10 | Increased serum lactate (HP:0002151) | 3.50383866 |
| 11 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.37770780 |
| 12 | Hypoplasia of the pons (HP:0012110) | 3.36395536 |
| 13 | IgG deficiency (HP:0004315) | 3.28745067 |
| 14 | Retrobulbar optic neuritis (HP:0100654) | 3.22165700 |
| 15 | Optic neuritis (HP:0100653) | 3.22165700 |
| 16 | Hepatocellular necrosis (HP:0001404) | 3.21343018 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.10659532 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.10659532 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.07472601 |
| 20 | Exertional dyspnea (HP:0002875) | 3.04184145 |
| 21 | Cerebral edema (HP:0002181) | 3.02426925 |
| 22 | Increased serum pyruvate (HP:0003542) | 3.00696197 |
| 23 | Type II lissencephaly (HP:0007260) | 3.00450151 |
| 24 | Large for gestational age (HP:0001520) | 2.95647235 |
| 25 | Testicular atrophy (HP:0000029) | 2.86742768 |
| 26 | Hepatic necrosis (HP:0002605) | 2.80896480 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.77039750 |
| 28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.76622550 |
| 29 | Abnormality of glycolysis (HP:0004366) | 2.66813704 |
| 30 | Pendular nystagmus (HP:0012043) | 2.66513937 |
| 31 | Chronic sinusitis (HP:0011109) | 2.62577906 |
| 32 | Optic disc pallor (HP:0000543) | 2.62430126 |
| 33 | Exercise intolerance (HP:0003546) | 2.60071200 |
| 34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.59118081 |
| 35 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.58894708 |
| 36 | Lactic acidosis (HP:0003128) | 2.58828509 |
| 37 | Orchitis (HP:0100796) | 2.48969010 |
| 38 | Pulmonary infiltrates (HP:0002113) | 2.48723251 |
| 39 | Abnormality of alanine metabolism (HP:0010916) | 2.35936718 |
| 40 | Hyperalaninemia (HP:0003348) | 2.35936718 |
| 41 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.35936718 |
| 42 | Abnormality of the labia minora (HP:0012880) | 2.34276656 |
| 43 | Respiratory failure (HP:0002878) | 2.29646946 |
| 44 | Increased muscle lipid content (HP:0009058) | 2.28720161 |
| 45 | Keratoconjunctivitis sicca (HP:0001097) | 2.27739836 |
| 46 | Myositis (HP:0100614) | 2.26345809 |
| 47 | Duplicated collecting system (HP:0000081) | 2.24419930 |
| 48 | Methylmalonic aciduria (HP:0012120) | 2.23086168 |
| 49 | Congenital stationary night blindness (HP:0007642) | 2.22921504 |
| 50 | Azoospermia (HP:0000027) | 2.21890931 |
| 51 | Abolished electroretinogram (ERG) (HP:0000550) | 2.21476931 |
| 52 | Central scotoma (HP:0000603) | 2.19299341 |
| 53 | Cleft eyelid (HP:0000625) | 2.18079726 |
| 54 | Cerebral hypomyelination (HP:0006808) | 2.16172831 |
| 55 | Methylmalonic acidemia (HP:0002912) | 2.16116389 |
| 56 | Keratoconjunctivitis (HP:0001096) | 2.12249564 |
| 57 | Chronic bronchitis (HP:0004469) | 2.10961331 |
| 58 | Leukodystrophy (HP:0002415) | 2.09649184 |
| 59 | Abnormality of methionine metabolism (HP:0010901) | 2.09377895 |
| 60 | Abnormality of the renal collecting system (HP:0004742) | 2.05399821 |
| 61 | Opisthotonus (HP:0002179) | 2.05112209 |
| 62 | Lethargy (HP:0001254) | 2.04264130 |
| 63 | Macrocytic anemia (HP:0001972) | 2.03992800 |
| 64 | Retinal dysplasia (HP:0007973) | 2.03829824 |
| 65 | Abnormality of midbrain morphology (HP:0002418) | 2.02588293 |
| 66 | Molar tooth sign on MRI (HP:0002419) | 2.02588293 |
| 67 | Congenital, generalized hypertrichosis (HP:0004540) | 2.02149862 |
| 68 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.01711707 |
| 69 | Hypomagnesemia (HP:0002917) | 2.01497107 |
| 70 | CNS demyelination (HP:0007305) | 1.99712341 |
| 71 | Pancreatic cysts (HP:0001737) | 1.99133434 |
| 72 | Premature ovarian failure (HP:0008209) | 1.98453423 |
| 73 | Constricted visual fields (HP:0001133) | 1.97589373 |
| 74 | Hypoproteinemia (HP:0003075) | 1.97338959 |
| 75 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.94635300 |
| 76 | Absent/shortened dynein arms (HP:0200106) | 1.94635300 |
| 77 | Abnormal spermatogenesis (HP:0008669) | 1.93869454 |
| 78 | Abnormal number of erythroid precursors (HP:0012131) | 1.92972938 |
| 79 | Type I transferrin isoform profile (HP:0003642) | 1.90384248 |
| 80 | Stomatitis (HP:0010280) | 1.89945553 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.89120109 |
| 82 | Glycosuria (HP:0003076) | 1.89120109 |
| 83 | Tetany (HP:0001281) | 1.89076461 |
| 84 | Bronchitis (HP:0012387) | 1.88025122 |
| 85 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.86231159 |
| 86 | Respiratory difficulties (HP:0002880) | 1.84801035 |
| 87 | Abnormality of T cells (HP:0002843) | 1.84320869 |
| 88 | B lymphocytopenia (HP:0010976) | 1.84113380 |
| 89 | Abnormality of B cell number (HP:0010975) | 1.83906697 |
| 90 | Parakeratosis (HP:0001036) | 1.83383132 |
| 91 | Reduced antithrombin III activity (HP:0001976) | 1.82510330 |
| 92 | Encephalitis (HP:0002383) | 1.81812207 |
| 93 | Megaloblastic anemia (HP:0001889) | 1.81709854 |
| 94 | Keratoconus (HP:0000563) | 1.81071740 |
| 95 | Increased corneal curvature (HP:0100692) | 1.81071740 |
| 96 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.80736355 |
| 97 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.80736355 |
| 98 | Abnormal albumin level (HP:0012116) | 1.80221069 |
| 99 | Hypoalbuminemia (HP:0003073) | 1.80221069 |
| 100 | Polyneuropathy (HP:0001271) | 1.80128308 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 5.63610323 |
| 2 | MST4 | 4.09039029 |
| 3 | VRK2 | 3.58335520 |
| 4 | EIF2AK1 | 3.53330580 |
| 5 | TLK1 | 3.52828589 |
| 6 | TXK | 3.30671690 |
| 7 | BUB1 | 2.97907490 |
| 8 | EIF2AK3 | 2.80389843 |
| 9 | TAF1 | 2.49958900 |
| 10 | ZAK | 2.34305470 |
| 11 | NEK1 | 2.27325622 |
| 12 | MAP4K2 | 2.17808359 |
| 13 | NUAK1 | 2.17383524 |
| 14 | SRPK1 | 1.96054483 |
| 15 | PLK3 | 1.82272459 |
| 16 | SCYL2 | 1.74217297 |
| 17 | GRK1 | 1.72841256 |
| 18 | MAP2K6 | 1.65705399 |
| 19 | VRK1 | 1.61927102 |
| 20 | ALK | 1.59595564 |
| 21 | PASK | 1.52686579 |
| 22 | ADRBK2 | 1.34507082 |
| 23 | FRK | 1.34409871 |
| 24 | MAP3K12 | 1.31152436 |
| 25 | MKNK2 | 1.28710051 |
| 26 | BMPR2 | 1.28176186 |
| 27 | KIT | 1.27163752 |
| 28 | STK39 | 1.18917327 |
| 29 | SMG1 | 1.18230695 |
| 30 | CDC7 | 1.16512259 |
| 31 | EIF2AK2 | 1.15713702 |
| 32 | INSRR | 1.10054611 |
| 33 | DAPK1 | 1.03554731 |
| 34 | WNK4 | 1.02298925 |
| 35 | DYRK2 | 1.00891357 |
| 36 | MKNK1 | 1.00022777 |
| 37 | FLT3 | 0.99618605 |
| 38 | PBK | 0.98287393 |
| 39 | DAPK2 | 0.97936551 |
| 40 | EPHA3 | 0.97352599 |
| 41 | STK38L | 0.96097092 |
| 42 | MYLK | 0.95943617 |
| 43 | TAOK3 | 0.95056425 |
| 44 | PLK4 | 0.90898818 |
| 45 | TIE1 | 0.88041006 |
| 46 | NME1 | 0.86282916 |
| 47 | ERBB3 | 0.81634107 |
| 48 | OXSR1 | 0.81589114 |
| 49 | TGFBR1 | 0.81117780 |
| 50 | BCKDK | 0.80366645 |
| 51 | NME2 | 0.79145413 |
| 52 | EPHA4 | 0.78052416 |
| 53 | ACVR1B | 0.71977552 |
| 54 | IKBKB | 0.69658327 |
| 55 | BMPR1B | 0.65057868 |
| 56 | AURKB | 0.60679550 |
| 57 | PDK2 | 0.60101357 |
| 58 | CDK8 | 0.59574066 |
| 59 | MAP4K1 | 0.59166245 |
| 60 | CLK1 | 0.56144616 |
| 61 | TYK2 | 0.53223253 |
| 62 | DAPK3 | 0.52844473 |
| 63 | ATR | 0.52101276 |
| 64 | STK16 | 0.51658255 |
| 65 | TRIM28 | 0.50230519 |
| 66 | WNK3 | 0.49399967 |
| 67 | RPS6KA4 | 0.48985443 |
| 68 | GRK5 | 0.47232782 |
| 69 | ILK | 0.43822809 |
| 70 | PLK2 | 0.43677626 |
| 71 | CSNK2A2 | 0.42044349 |
| 72 | TEC | 0.41969880 |
| 73 | CSNK2A1 | 0.41331133 |
| 74 | PLK1 | 0.40516140 |
| 75 | FGFR1 | 0.38969945 |
| 76 | STK3 | 0.38934899 |
| 77 | ITK | 0.36651053 |
| 78 | RPS6KA5 | 0.35933699 |
| 79 | MAP3K14 | 0.35429297 |
| 80 | PHKG1 | 0.34837415 |
| 81 | PHKG2 | 0.34837415 |
| 82 | CSNK1A1L | 0.34736031 |
| 83 | MAPKAPK5 | 0.32094369 |
| 84 | FGFR3 | 0.31371945 |
| 85 | JAK3 | 0.31295548 |
| 86 | CSNK1G3 | 0.31289225 |
| 87 | AKT3 | 0.31240316 |
| 88 | CCNB1 | 0.31126932 |
| 89 | FGFR4 | 0.30711167 |
| 90 | WEE1 | 0.30550596 |
| 91 | TTK | 0.28519005 |
| 92 | JAK1 | 0.28350829 |
| 93 | CSNK1E | 0.28170143 |
| 94 | PRKCE | 0.28129824 |
| 95 | PIK3CG | 0.27958868 |
| 96 | SYK | 0.27172021 |
| 97 | CHEK2 | 0.26771939 |
| 98 | CHUK | 0.25620038 |
| 99 | IRAK1 | 0.24714517 |
| 100 | IGF1R | 0.23038081 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.03231434 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.21049621 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.19849926 |
| 4 | Asthma_Homo sapiens_hsa05310 | 2.96557452 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.76829988 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.70017583 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.56406624 |
| 8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.52917880 |
| 9 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.51279572 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.31319831 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.19026090 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.06785814 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 2.00944693 |
| 14 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.93547653 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.93160194 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.87901143 |
| 17 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.86231763 |
| 18 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.83879041 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.83017677 |
| 20 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.76744574 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.73150363 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.63818285 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.61455302 |
| 24 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.55888935 |
| 25 | Spliceosome_Homo sapiens_hsa03040 | 1.54524561 |
| 26 | DNA replication_Homo sapiens_hsa03030 | 1.50590192 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.46263593 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.40520805 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.39479839 |
| 30 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.37262161 |
| 31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.36552409 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.34326662 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.34127921 |
| 34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29373470 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.25693261 |
| 36 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.20208951 |
| 37 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.17750353 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.09717656 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.02990892 |
| 40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.99351218 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 0.97341885 |
| 42 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.94419837 |
| 43 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.92182241 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.90237363 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.90186398 |
| 46 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89759921 |
| 47 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.85235849 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.85225948 |
| 49 | Sulfur relay system_Homo sapiens_hsa04122 | 0.84591902 |
| 50 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.82614272 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.81790047 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.80874863 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.80710945 |
| 54 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.75485378 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.67386813 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.65810845 |
| 57 | Viral myocarditis_Homo sapiens_hsa05416 | 0.63430772 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62430564 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.61525770 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60449972 |
| 61 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59349485 |
| 62 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.59305462 |
| 63 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57766936 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.57072559 |
| 65 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.51558537 |
| 66 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.51344530 |
| 67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.50318702 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49393026 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49363836 |
| 70 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48353700 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.46466295 |
| 72 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.46081914 |
| 73 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43504643 |
| 74 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43501714 |
| 75 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.43330307 |
| 76 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.42985643 |
| 77 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42785135 |
| 78 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42601732 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41598489 |
| 80 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.40609197 |
| 81 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39186066 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.37007105 |
| 83 | Peroxisome_Homo sapiens_hsa04146 | 0.36431085 |
| 84 | Measles_Homo sapiens_hsa05162 | 0.35189533 |
| 85 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.34789094 |
| 86 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.33566095 |
| 87 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.32973620 |
| 88 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31275374 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30815689 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.29591748 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28985674 |
| 92 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.28907624 |
| 93 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27984165 |
| 94 | Carbon metabolism_Homo sapiens_hsa01200 | 0.27149675 |
| 95 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.26210192 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.26205672 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.24409678 |
| 98 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.24033061 |
| 99 | Retinol metabolism_Homo sapiens_hsa00830 | 0.22985348 |
| 100 | Legionellosis_Homo sapiens_hsa05134 | 0.22496321 |

