

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.74221194 |
| 2 | DNA deamination (GO:0045006) | 5.27732652 |
| 3 | rRNA modification (GO:0000154) | 4.81650336 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.29333725 |
| 5 | rRNA methylation (GO:0031167) | 4.24218726 |
| 6 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.10984756 |
| 7 | ribosome assembly (GO:0042255) | 4.07722005 |
| 8 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.06738784 |
| 9 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.06738784 |
| 10 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.03629920 |
| 11 | protein neddylation (GO:0045116) | 4.01728362 |
| 12 | IMP biosynthetic process (GO:0006188) | 3.94671421 |
| 13 | regulation of immunoglobulin secretion (GO:0051023) | 3.88429331 |
| 14 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.85716782 |
| 15 | pseudouridine synthesis (GO:0001522) | 3.81845008 |
| 16 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.77278532 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.76422475 |
| 18 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.75363410 |
| 19 | chaperone-mediated protein transport (GO:0072321) | 3.74371476 |
| 20 | respiratory chain complex IV assembly (GO:0008535) | 3.73605278 |
| 21 | protein complex biogenesis (GO:0070271) | 3.69803111 |
| 22 | IMP metabolic process (GO:0046040) | 3.65634966 |
| 23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.63813841 |
| 24 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.62216141 |
| 25 | isotype switching (GO:0045190) | 3.62216141 |
| 26 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.62216141 |
| 27 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.59767635 |
| 28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58775545 |
| 29 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58775545 |
| 30 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58775545 |
| 31 | purine nucleobase biosynthetic process (GO:0009113) | 3.55615712 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.54402466 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.54402466 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.54402466 |
| 35 | nucleobase biosynthetic process (GO:0046112) | 3.52922541 |
| 36 | ribosome biogenesis (GO:0042254) | 3.52919132 |
| 37 | GTP biosynthetic process (GO:0006183) | 3.52687936 |
| 38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.51917852 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.50882937 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.50882937 |
| 41 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.49704303 |
| 42 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.47080822 |
| 43 | cullin deneddylation (GO:0010388) | 3.45720897 |
| 44 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.45509100 |
| 45 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.40202746 |
| 46 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.36831938 |
| 47 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.36831938 |
| 48 | negative regulation of ligase activity (GO:0051352) | 3.34599170 |
| 49 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.34599170 |
| 50 | chromatin remodeling at centromere (GO:0031055) | 3.34197457 |
| 51 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.31732552 |
| 52 | maturation of 5.8S rRNA (GO:0000460) | 3.30537087 |
| 53 | termination of RNA polymerase III transcription (GO:0006386) | 3.29362454 |
| 54 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.29362454 |
| 55 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.28514889 |
| 56 | ATP synthesis coupled proton transport (GO:0015986) | 3.28514889 |
| 57 | cytochrome complex assembly (GO:0017004) | 3.27048964 |
| 58 | CENP-A containing nucleosome assembly (GO:0034080) | 3.26666245 |
| 59 | protein deneddylation (GO:0000338) | 3.23991490 |
| 60 | rRNA processing (GO:0006364) | 3.19739430 |
| 61 | regulation of chronic inflammatory response (GO:0002676) | 3.19625047 |
| 62 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.18767715 |
| 63 | purine nucleotide salvage (GO:0032261) | 3.18531245 |
| 64 | DNA double-strand break processing (GO:0000729) | 3.15427801 |
| 65 | mitochondrial RNA metabolic process (GO:0000959) | 3.14373100 |
| 66 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.14295635 |
| 67 | positive regulation of DNA recombination (GO:0045911) | 3.14168470 |
| 68 | rRNA metabolic process (GO:0016072) | 3.12482006 |
| 69 | positive regulation of isotype switching (GO:0045830) | 3.10649917 |
| 70 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.08790108 |
| 71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.07861698 |
| 72 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.07359953 |
| 73 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.05746986 |
| 74 | tRNA processing (GO:0008033) | 3.05025859 |
| 75 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.04767652 |
| 76 | cytidine metabolic process (GO:0046087) | 3.03827542 |
| 77 | cytidine catabolic process (GO:0006216) | 3.03827542 |
| 78 | cytidine deamination (GO:0009972) | 3.03827542 |
| 79 | UTP biosynthetic process (GO:0006228) | 3.03600767 |
| 80 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.02229796 |
| 81 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.02212384 |
| 82 | platelet dense granule organization (GO:0060155) | 2.98025752 |
| 83 | tRNA metabolic process (GO:0006399) | 2.95090719 |
| 84 | positive regulation of ligase activity (GO:0051351) | 2.94667234 |
| 85 | cellular component biogenesis (GO:0044085) | 2.92972469 |
| 86 | protein targeting to mitochondrion (GO:0006626) | 2.92690061 |
| 87 | DNA damage response, detection of DNA damage (GO:0042769) | 2.92486815 |
| 88 | transcription from mitochondrial promoter (GO:0006390) | 2.91383694 |
| 89 | ribosomal large subunit biogenesis (GO:0042273) | 2.90568614 |
| 90 | CTP metabolic process (GO:0046036) | 2.84444960 |
| 91 | CTP biosynthetic process (GO:0006241) | 2.84444960 |
| 92 | ncRNA metabolic process (GO:0034660) | 2.82161386 |
| 93 | protein-cofactor linkage (GO:0018065) | 2.82146070 |
| 94 | adenosine metabolic process (GO:0046085) | 2.81902850 |
| 95 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.80902377 |
| 96 | UTP metabolic process (GO:0046051) | 2.80730499 |
| 97 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.79300192 |
| 98 | termination of RNA polymerase I transcription (GO:0006363) | 2.78479353 |
| 99 | protein localization to mitochondrion (GO:0070585) | 2.77435285 |
| 100 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.76613737 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.28266549 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.72725955 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.24670678 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.93133234 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.29646333 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.03470450 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.99437531 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.91424208 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.90361356 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.85844690 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.84707568 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.81426384 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.62505375 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.50462552 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.46675708 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.46541191 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.42298988 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42196970 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.25839524 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.24689009 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.23893070 |
| 22 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.06496846 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.99763261 |
| 24 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94375573 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.91897181 |
| 26 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.89056313 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.86860609 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.86065704 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.83425741 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.82778200 |
| 31 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.80869031 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.78207609 |
| 33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.76425892 |
| 34 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.68868231 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.62946649 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.59193015 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.58566854 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.58554218 |
| 39 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.58410015 |
| 40 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.50896513 |
| 41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.50473372 |
| 42 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.38765111 |
| 43 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.38704989 |
| 44 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.37781960 |
| 45 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.35227801 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.32803985 |
| 47 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32062430 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.31652603 |
| 49 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30518734 |
| 50 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.27272218 |
| 51 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.26074954 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19736958 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.18742808 |
| 54 | GATA3_26560356_Chip-Seq_TH2_Human | 1.18641696 |
| 55 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.18240366 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16910306 |
| 57 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.15676498 |
| 58 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.15676498 |
| 59 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.11483169 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11358232 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09488426 |
| 62 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07574133 |
| 63 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07506895 |
| 64 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.06872688 |
| 65 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.06722040 |
| 66 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06573070 |
| 67 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.06502463 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.05417551 |
| 69 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.05035844 |
| 70 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.04871175 |
| 71 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.04214489 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03482941 |
| 73 | P300_19829295_ChIP-Seq_ESCs_Human | 1.03387347 |
| 74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.03155270 |
| 75 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.02323905 |
| 76 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00896141 |
| 77 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00896141 |
| 78 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.00891966 |
| 79 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.00322535 |
| 80 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.99153567 |
| 81 | MYB_26560356_Chip-Seq_TH2_Human | 0.97937125 |
| 82 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.97755695 |
| 83 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.97483791 |
| 84 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.95438716 |
| 85 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.95176779 |
| 86 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94167595 |
| 87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.90392391 |
| 88 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89925390 |
| 89 | NCOR_22424771_ChIP-Seq_293T_Human | 0.88936641 |
| 90 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.88744115 |
| 91 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.88255063 |
| 92 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87261568 |
| 93 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.86793775 |
| 94 | AR_20517297_ChIP-Seq_VCAP_Human | 0.86068348 |
| 95 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.85037203 |
| 96 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84875307 |
| 97 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.84581098 |
| 98 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.84115005 |
| 99 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.83945014 |
| 100 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.83739735 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.66631778 |
| 2 | MP0004147_increased_porphyrin_level | 3.33299099 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.03074634 |
| 4 | MP0000685_abnormal_immune_system | 2.80489826 |
| 5 | MP0005671_abnormal_response_to | 2.60609107 |
| 6 | MP0002102_abnormal_ear_morphology | 2.59631760 |
| 7 | MP0008058_abnormal_DNA_repair | 2.50997875 |
| 8 | MP0002138_abnormal_hepatobiliary_system | 2.40336773 |
| 9 | MP0003786_premature_aging | 2.35563348 |
| 10 | MP0008872_abnormal_physiological_respon | 2.29203620 |
| 11 | MP0003195_calcinosis | 2.26491569 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.25696924 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.24483142 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.14582707 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 2.14238100 |
| 16 | MP0003718_maternal_effect | 2.07495148 |
| 17 | MP0001873_stomach_inflammation | 2.01806608 |
| 18 | MP0009785_altered_susceptibility_to | 1.99823695 |
| 19 | MP0002736_abnormal_nociception_after | 1.98064932 |
| 20 | MP0003646_muscle_fatigue | 1.90241789 |
| 21 | MP0002148_abnormal_hypersensitivity_rea | 1.88726881 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 1.84066240 |
| 23 | MP0006036_abnormal_mitochondrial_physio | 1.84020004 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 1.80086328 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.75620824 |
| 26 | MP0001790_abnormal_immune_system | 1.74759330 |
| 27 | MP0005387_immune_system_phenotype | 1.74759330 |
| 28 | MP0001968_abnormal_touch/_nociception | 1.74732689 |
| 29 | MP0003806_abnormal_nucleotide_metabolis | 1.66068367 |
| 30 | MP0008995_early_reproductive_senescence | 1.64625625 |
| 31 | MP0001800_abnormal_humoral_immune | 1.59458603 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.59319544 |
| 33 | MP0006292_abnormal_olfactory_placode | 1.56422162 |
| 34 | MP0001348_abnormal_lacrimal_gland | 1.51488932 |
| 35 | MP0002006_tumorigenesis | 1.50566863 |
| 36 | MP0002277_abnormal_respiratory_mucosa | 1.48114592 |
| 37 | MP0002166_altered_tumor_susceptibility | 1.42343944 |
| 38 | MP0003186_abnormal_redox_activity | 1.41597146 |
| 39 | MP0009697_abnormal_copulation | 1.39043528 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.38473082 |
| 41 | MP0002837_dystrophic_cardiac_calcinosis | 1.37618419 |
| 42 | MP0003878_abnormal_ear_physiology | 1.35919955 |
| 43 | MP0005377_hearing/vestibular/ear_phenot | 1.35919955 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.32963296 |
| 45 | MP0008057_abnormal_DNA_replication | 1.24462640 |
| 46 | MP0001188_hyperpigmentation | 1.24280125 |
| 47 | MP0005000_abnormal_immune_tolerance | 1.22678143 |
| 48 | MP0008007_abnormal_cellular_replicative | 1.22522332 |
| 49 | MP0004782_abnormal_surfactant_physiolog | 1.21724990 |
| 50 | MP0006035_abnormal_mitochondrial_morpho | 1.19520867 |
| 51 | MP0001293_anophthalmia | 1.19310358 |
| 52 | MP0004885_abnormal_endolymph | 1.18609243 |
| 53 | MP0001661_extended_life_span | 1.17582243 |
| 54 | MP0003077_abnormal_cell_cycle | 1.15719018 |
| 55 | MP0004145_abnormal_muscle_electrophysio | 1.15710853 |
| 56 | MP0005360_urolithiasis | 1.14930414 |
| 57 | MP0005084_abnormal_gallbladder_morpholo | 1.14305178 |
| 58 | MP0003763_abnormal_thymus_physiology | 1.13220307 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.11955344 |
| 60 | MP0005551_abnormal_eye_electrophysiolog | 1.09638574 |
| 61 | MP0001853_heart_inflammation | 1.06895443 |
| 62 | MP0002723_abnormal_immune_serum | 1.06704008 |
| 63 | MP0000689_abnormal_spleen_morphology | 1.05943328 |
| 64 | MP0001529_abnormal_vocalization | 1.03541117 |
| 65 | MP0003111_abnormal_nucleus_morphology | 1.02164174 |
| 66 | MP0002398_abnormal_bone_marrow | 1.00523354 |
| 67 | MP0004043_abnormal_pH_regulation | 1.00505124 |
| 68 | MP0001764_abnormal_homeostasis | 0.97397219 |
| 69 | MP0002452_abnormal_antigen_presenting | 0.96463019 |
| 70 | MP0005389_reproductive_system_phenotype | 0.96093489 |
| 71 | MP0002420_abnormal_adaptive_immunity | 0.94974521 |
| 72 | MP0000703_abnormal_thymus_morphology | 0.93554060 |
| 73 | MP0002876_abnormal_thyroid_physiology | 0.93497503 |
| 74 | MP0002160_abnormal_reproductive_system | 0.91869390 |
| 75 | MP0001819_abnormal_immune_cell | 0.91686325 |
| 76 | MP0002735_abnormal_chemical_nociception | 0.89575803 |
| 77 | MP0002210_abnormal_sex_determination | 0.89148958 |
| 78 | MP0003724_increased_susceptibility_to | 0.87783279 |
| 79 | MP0001485_abnormal_pinna_reflex | 0.87611400 |
| 80 | MP0000716_abnormal_immune_system | 0.86628292 |
| 81 | MP0002405_respiratory_system_inflammati | 0.86459497 |
| 82 | MP0005636_abnormal_mineral_homeostasis | 0.86403503 |
| 83 | MP0005410_abnormal_fertilization | 0.85910892 |
| 84 | MP0005332_abnormal_amino_acid | 0.85895823 |
| 85 | MP0003866_abnormal_defecation | 0.83199246 |
| 86 | MP0002722_abnormal_immune_system | 0.82009857 |
| 87 | MP0009764_decreased_sensitivity_to | 0.80942435 |
| 88 | MP0002429_abnormal_blood_cell | 0.79378361 |
| 89 | MP0005025_abnormal_response_to | 0.79240342 |
| 90 | MP0010155_abnormal_intestine_physiology | 0.78528337 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.78418331 |
| 92 | MP0001986_abnormal_taste_sensitivity | 0.77048775 |
| 93 | MP0005379_endocrine/exocrine_gland_phen | 0.76688816 |
| 94 | MP0001984_abnormal_olfaction | 0.76677220 |
| 95 | MP0004142_abnormal_muscle_tone | 0.76329626 |
| 96 | MP0002938_white_spotting | 0.75729180 |
| 97 | MP0001929_abnormal_gametogenesis | 0.75283962 |
| 98 | MP0002019_abnormal_tumor_incidence | 0.74126224 |
| 99 | MP0003011_delayed_dark_adaptation | 0.72961940 |
| 100 | MP0001501_abnormal_sleep_pattern | 0.72874531 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 4.80387758 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.48378919 |
| 3 | Increased CSF lactate (HP:0002490) | 4.12818770 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.11906338 |
| 5 | Acute encephalopathy (HP:0006846) | 4.07375230 |
| 6 | Abnormality of alanine metabolism (HP:0010916) | 3.93618018 |
| 7 | Hyperalaninemia (HP:0003348) | 3.93618018 |
| 8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.93618018 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.89604362 |
| 10 | Progressive macrocephaly (HP:0004481) | 3.68142293 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.59762763 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.57566322 |
| 13 | IgG deficiency (HP:0004315) | 3.31289513 |
| 14 | Hepatic necrosis (HP:0002605) | 3.28454612 |
| 15 | Increased serum lactate (HP:0002151) | 3.22238150 |
| 16 | Aplastic anemia (HP:0001915) | 3.18803338 |
| 17 | Methylmalonic acidemia (HP:0002912) | 3.11308808 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 3.07038345 |
| 19 | Cerebral edema (HP:0002181) | 3.06568585 |
| 20 | Methylmalonic aciduria (HP:0012120) | 2.97607220 |
| 21 | Constricted visual fields (HP:0001133) | 2.92432994 |
| 22 | 3-Methylglutaconic aciduria (HP:0003535) | 2.91951005 |
| 23 | Severe combined immunodeficiency (HP:0004430) | 2.85754950 |
| 24 | Abnormality of serum amino acid levels (HP:0003112) | 2.81397016 |
| 25 | Lactic acidosis (HP:0003128) | 2.71216224 |
| 26 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.68304219 |
| 27 | Type 2 muscle fiber atrophy (HP:0003554) | 2.64221368 |
| 28 | Exertional dyspnea (HP:0002875) | 2.61643826 |
| 29 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.61391871 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.60879391 |
| 31 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.59309434 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 2.50369324 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 2.50369324 |
| 34 | Abnormality of T cell physiology (HP:0011840) | 2.50029046 |
| 35 | Optic disc pallor (HP:0000543) | 2.45525021 |
| 36 | Thyroiditis (HP:0100646) | 2.44913670 |
| 37 | Abnormality of the pons (HP:0007361) | 2.44688663 |
| 38 | Hyperglycinemia (HP:0002154) | 2.43047420 |
| 39 | Hypoproteinemia (HP:0003075) | 2.42947944 |
| 40 | Abnormality of T cells (HP:0002843) | 2.41550606 |
| 41 | Congenital stationary night blindness (HP:0007642) | 2.40161754 |
| 42 | Lethargy (HP:0001254) | 2.39112100 |
| 43 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36772936 |
| 44 | Increased serum pyruvate (HP:0003542) | 2.35570638 |
| 45 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.27772388 |
| 46 | Combined immunodeficiency (HP:0005387) | 2.26568500 |
| 47 | Abolished electroretinogram (ERG) (HP:0000550) | 2.25576065 |
| 48 | Respiratory failure (HP:0002878) | 2.23703598 |
| 49 | Increased IgM level (HP:0003496) | 2.21716458 |
| 50 | Pancreatic cysts (HP:0001737) | 2.21356071 |
| 51 | Hypoplasia of the pons (HP:0012110) | 2.17961010 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.17757410 |
| 53 | Muscle fiber atrophy (HP:0100295) | 2.17286945 |
| 54 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.16846970 |
| 55 | Exercise intolerance (HP:0003546) | 2.16522990 |
| 56 | Leukodystrophy (HP:0002415) | 2.16160723 |
| 57 | Pancytopenia (HP:0001876) | 2.15519446 |
| 58 | T lymphocytopenia (HP:0005403) | 2.15072830 |
| 59 | Pendular nystagmus (HP:0012043) | 2.13036097 |
| 60 | Abnormality of methionine metabolism (HP:0010901) | 2.09906961 |
| 61 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.08942356 |
| 62 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.08814657 |
| 63 | B lymphocytopenia (HP:0010976) | 2.08595338 |
| 64 | Nephronophthisis (HP:0000090) | 2.07855866 |
| 65 | Abnormality of B cell number (HP:0010975) | 2.07375776 |
| 66 | Testicular atrophy (HP:0000029) | 2.06886245 |
| 67 | Abnormality of T cell number (HP:0011839) | 2.05675869 |
| 68 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.04359489 |
| 69 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.04359489 |
| 70 | Panhypogammaglobulinemia (HP:0003139) | 2.03329894 |
| 71 | Abnormality of glycolysis (HP:0004366) | 2.03056166 |
| 72 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.02151089 |
| 73 | Colon cancer (HP:0003003) | 2.00872765 |
| 74 | Abnormality of glycine metabolism (HP:0010895) | 1.99020498 |
| 75 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.99020498 |
| 76 | IgA deficiency (HP:0002720) | 1.98219990 |
| 77 | Respiratory difficulties (HP:0002880) | 1.97826102 |
| 78 | Abnormality of the renal collecting system (HP:0004742) | 1.93801061 |
| 79 | Neutropenia (HP:0001875) | 1.93669453 |
| 80 | Congenital, generalized hypertrichosis (HP:0004540) | 1.92208709 |
| 81 | Duplicated collecting system (HP:0000081) | 1.91998137 |
| 82 | Attenuation of retinal blood vessels (HP:0007843) | 1.90827010 |
| 83 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.88282181 |
| 84 | Abnormality of the labia minora (HP:0012880) | 1.87590472 |
| 85 | Abnormality of vitamin B metabolism (HP:0004340) | 1.87232791 |
| 86 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.86319756 |
| 87 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.86319756 |
| 88 | Abnormal protein glycosylation (HP:0012346) | 1.86319756 |
| 89 | Abnormal glycosylation (HP:0012345) | 1.86319756 |
| 90 | Abnormality of the ileum (HP:0001549) | 1.85267654 |
| 91 | Megaloblastic anemia (HP:0001889) | 1.84552684 |
| 92 | Meckel diverticulum (HP:0002245) | 1.81512556 |
| 93 | Hyperglycinuria (HP:0003108) | 1.80897669 |
| 94 | Cerebral hypomyelination (HP:0006808) | 1.80417810 |
| 95 | CNS demyelination (HP:0007305) | 1.78853964 |
| 96 | Abnormality of eosinophils (HP:0001879) | 1.76041795 |
| 97 | Homocystinuria (HP:0002156) | 1.75820378 |
| 98 | Abnormality of homocysteine metabolism (HP:0010919) | 1.75820378 |
| 99 | Abnormality of the prostate (HP:0008775) | 1.75079232 |
| 100 | Delayed CNS myelination (HP:0002188) | 1.75011560 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 3.87653950 |
| 2 | MST4 | 3.42540506 |
| 3 | VRK2 | 3.24128671 |
| 4 | EIF2AK3 | 3.20206001 |
| 5 | NUAK1 | 3.14162217 |
| 6 | TXK | 2.53802122 |
| 7 | ZAK | 2.44717510 |
| 8 | BUB1 | 2.43379363 |
| 9 | EIF2AK1 | 2.35556822 |
| 10 | SRPK1 | 2.31184416 |
| 11 | NEK1 | 2.20747757 |
| 12 | PLK3 | 2.15103447 |
| 13 | NME1 | 2.07934472 |
| 14 | VRK1 | 2.05424596 |
| 15 | PBK | 2.02094217 |
| 16 | MAP4K2 | 2.00980293 |
| 17 | ADRBK2 | 2.00027120 |
| 18 | MKNK2 | 1.89954241 |
| 19 | TLK1 | 1.84067426 |
| 20 | MKNK1 | 1.83955107 |
| 21 | TAF1 | 1.83091376 |
| 22 | WNK4 | 1.70684230 |
| 23 | TEC | 1.67145044 |
| 24 | BMPR1B | 1.66441760 |
| 25 | TRIM28 | 1.65511227 |
| 26 | PLK4 | 1.63160145 |
| 27 | EIF2AK2 | 1.53788234 |
| 28 | ACVR1B | 1.50225282 |
| 29 | TAOK3 | 1.49423826 |
| 30 | OXSR1 | 1.46680624 |
| 31 | GRK1 | 1.45897977 |
| 32 | STK39 | 1.41230915 |
| 33 | FRK | 1.40925887 |
| 34 | PDK2 | 1.29914089 |
| 35 | STK16 | 1.28859522 |
| 36 | PLK2 | 1.24019801 |
| 37 | WNK3 | 1.22537440 |
| 38 | ITK | 1.21460156 |
| 39 | PASK | 1.08097984 |
| 40 | BCR | 1.05662302 |
| 41 | ALK | 1.02075582 |
| 42 | MAP3K12 | 0.99208539 |
| 43 | TGFBR1 | 0.96731262 |
| 44 | BCKDK | 0.96033743 |
| 45 | CDC7 | 0.94233509 |
| 46 | TIE1 | 0.88142450 |
| 47 | DAPK1 | 0.83593754 |
| 48 | DYRK2 | 0.81644192 |
| 49 | PLK1 | 0.81488814 |
| 50 | CSNK1G3 | 0.75388626 |
| 51 | IKBKB | 0.72068043 |
| 52 | CSNK1G1 | 0.70312607 |
| 53 | ATR | 0.69355347 |
| 54 | CDK8 | 0.69289110 |
| 55 | CSNK1A1L | 0.67726109 |
| 56 | BRSK2 | 0.66562589 |
| 57 | GRK5 | 0.65791594 |
| 58 | MAP2K6 | 0.63236874 |
| 59 | KDR | 0.60998606 |
| 60 | SYK | 0.58133679 |
| 61 | ADRBK1 | 0.57094882 |
| 62 | TNIK | 0.56875312 |
| 63 | MAPKAPK5 | 0.56269084 |
| 64 | INSRR | 0.55163171 |
| 65 | TTK | 0.54240944 |
| 66 | CSNK1G2 | 0.53313688 |
| 67 | SIK3 | 0.52870444 |
| 68 | IKBKE | 0.49138473 |
| 69 | AURKB | 0.44581998 |
| 70 | RPS6KA5 | 0.44424337 |
| 71 | KIT | 0.44117333 |
| 72 | CSNK2A2 | 0.43318363 |
| 73 | JAK3 | 0.43269038 |
| 74 | PIK3CG | 0.43144956 |
| 75 | DAPK2 | 0.42810376 |
| 76 | FGFR1 | 0.42204996 |
| 77 | WEE1 | 0.41265736 |
| 78 | CSNK2A1 | 0.41246696 |
| 79 | BTK | 0.40824620 |
| 80 | LCK | 0.40173950 |
| 81 | ERBB3 | 0.39257758 |
| 82 | IGF1R | 0.38966769 |
| 83 | STK4 | 0.37651668 |
| 84 | FLT3 | 0.37082770 |
| 85 | PRKCQ | 0.36286294 |
| 86 | CDK9 | 0.36242772 |
| 87 | STK3 | 0.35424005 |
| 88 | PRKCE | 0.33810478 |
| 89 | CSNK1A1 | 0.32345286 |
| 90 | RPS6KA4 | 0.31782738 |
| 91 | NLK | 0.31663072 |
| 92 | PAK4 | 0.30230551 |
| 93 | PRKCI | 0.29930195 |
| 94 | PHKG1 | 0.29862189 |
| 95 | PHKG2 | 0.29862189 |
| 96 | PAK3 | 0.28875119 |
| 97 | PINK1 | 0.28630770 |
| 98 | CSNK1E | 0.28410268 |
| 99 | CCNB1 | 0.27357044 |
| 100 | PRKCG | 0.27040378 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.97812862 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.35810098 |
| 3 | Asthma_Homo sapiens_hsa05310 | 3.16362548 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.03823167 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.56129736 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.53015359 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.49551874 |
| 8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.35678648 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.32104031 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.27220258 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.15114167 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.12040499 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 1.97761485 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.91872549 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 1.90808922 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.83496411 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.81748999 |
| 18 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.79257178 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.78703153 |
| 20 | Mismatch repair_Homo sapiens_hsa03430 | 1.77605666 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.71751594 |
| 22 | DNA replication_Homo sapiens_hsa03030 | 1.69602391 |
| 23 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.65759864 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.62015542 |
| 25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.49217752 |
| 26 | Spliceosome_Homo sapiens_hsa03040 | 1.48379633 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.47602654 |
| 28 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.44897235 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.41025110 |
| 30 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.41004226 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.39866536 |
| 32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.35384724 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.31331474 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.29067069 |
| 35 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.28472574 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.26424698 |
| 37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.25635417 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.24616161 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.23941223 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.21462713 |
| 41 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16811778 |
| 42 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.06335891 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.05936192 |
| 44 | Base excision repair_Homo sapiens_hsa03410 | 1.01231228 |
| 45 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.98309367 |
| 46 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.96883676 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.96286797 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.91139650 |
| 49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85302111 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.82580742 |
| 51 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.82394892 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.80522369 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.79761728 |
| 54 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.77974039 |
| 55 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.76844501 |
| 56 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.72840429 |
| 57 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.71128734 |
| 58 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.69817731 |
| 59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.69647591 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.69133061 |
| 61 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67870930 |
| 62 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.61797817 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.61217809 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.60939161 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58701902 |
| 66 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.56250946 |
| 67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54843000 |
| 68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.54198247 |
| 69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.53698841 |
| 70 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52833896 |
| 71 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.52117158 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.51807479 |
| 73 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.50948258 |
| 74 | Retinol metabolism_Homo sapiens_hsa00830 | 0.50477314 |
| 75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.48021615 |
| 76 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47824690 |
| 77 | Viral myocarditis_Homo sapiens_hsa05416 | 0.46643745 |
| 78 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.44401280 |
| 79 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43945845 |
| 80 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.43236685 |
| 81 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.39919926 |
| 82 | Measles_Homo sapiens_hsa05162 | 0.39274719 |
| 83 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.37635504 |
| 84 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.36159815 |
| 85 | Carbon metabolism_Homo sapiens_hsa01200 | 0.33569729 |
| 86 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.31067408 |
| 87 | Cell cycle_Homo sapiens_hsa04110 | 0.30783910 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30585573 |
| 89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.30469290 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.30369455 |
| 91 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.29551050 |
| 92 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29287078 |
| 93 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29254995 |
| 94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28325566 |
| 95 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.28258675 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27550862 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.25032639 |
| 98 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24342582 |
| 99 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.23411445 |
| 100 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.20212918 |

