NPM1P21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.74221194
2DNA deamination (GO:0045006)5.27732652
3rRNA modification (GO:0000154)4.81650336
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.29333725
5rRNA methylation (GO:0031167)4.24218726
6regulation of isotype switching to IgG isotypes (GO:0048302)4.10984756
7ribosome assembly (GO:0042255)4.07722005
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.06738784
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.06738784
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.03629920
11protein neddylation (GO:0045116)4.01728362
12IMP biosynthetic process (GO:0006188)3.94671421
13regulation of immunoglobulin secretion (GO:0051023)3.88429331
14water-soluble vitamin biosynthetic process (GO:0042364)3.85716782
15pseudouridine synthesis (GO:0001522)3.81845008
16regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.77278532
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76422475
18regulation of cellular amino acid metabolic process (GO:0006521)3.75363410
19chaperone-mediated protein transport (GO:0072321)3.74371476
20respiratory chain complex IV assembly (GO:0008535)3.73605278
21protein complex biogenesis (GO:0070271)3.69803111
22IMP metabolic process (GO:0046040)3.65634966
23mitochondrial respiratory chain complex assembly (GO:0033108)3.63813841
24somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.62216141
25isotype switching (GO:0045190)3.62216141
26somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.62216141
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.59767635
28NADH dehydrogenase complex assembly (GO:0010257)3.58775545
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58775545
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.58775545
31purine nucleobase biosynthetic process (GO:0009113)3.55615712
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54402466
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54402466
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54402466
35nucleobase biosynthetic process (GO:0046112)3.52922541
36ribosome biogenesis (GO:0042254)3.52919132
37GTP biosynthetic process (GO:0006183)3.52687936
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51917852
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50882937
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50882937
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49704303
42folic acid-containing compound biosynthetic process (GO:0009396)3.47080822
43cullin deneddylation (GO:0010388)3.45720897
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45509100
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40202746
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36831938
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.36831938
48negative regulation of ligase activity (GO:0051352)3.34599170
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34599170
50chromatin remodeling at centromere (GO:0031055)3.34197457
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.31732552
52maturation of 5.8S rRNA (GO:0000460)3.30537087
53termination of RNA polymerase III transcription (GO:0006386)3.29362454
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.29362454
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28514889
56ATP synthesis coupled proton transport (GO:0015986)3.28514889
57cytochrome complex assembly (GO:0017004)3.27048964
58CENP-A containing nucleosome assembly (GO:0034080)3.26666245
59protein deneddylation (GO:0000338)3.23991490
60rRNA processing (GO:0006364)3.19739430
61regulation of chronic inflammatory response (GO:0002676)3.19625047
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18767715
63purine nucleotide salvage (GO:0032261)3.18531245
64DNA double-strand break processing (GO:0000729)3.15427801
65mitochondrial RNA metabolic process (GO:0000959)3.14373100
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14295635
67positive regulation of DNA recombination (GO:0045911)3.14168470
68rRNA metabolic process (GO:0016072)3.12482006
69positive regulation of isotype switching (GO:0045830)3.10649917
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08790108
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07861698
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07359953
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05746986
74tRNA processing (GO:0008033)3.05025859
75guanosine-containing compound biosynthetic process (GO:1901070)3.04767652
76cytidine metabolic process (GO:0046087)3.03827542
77cytidine catabolic process (GO:0006216)3.03827542
78cytidine deamination (GO:0009972)3.03827542
79UTP biosynthetic process (GO:0006228)3.03600767
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02229796
81DNA catabolic process, exonucleolytic (GO:0000738)3.02212384
82platelet dense granule organization (GO:0060155)2.98025752
83tRNA metabolic process (GO:0006399)2.95090719
84positive regulation of ligase activity (GO:0051351)2.94667234
85cellular component biogenesis (GO:0044085)2.92972469
86protein targeting to mitochondrion (GO:0006626)2.92690061
87DNA damage response, detection of DNA damage (GO:0042769)2.92486815
88transcription from mitochondrial promoter (GO:0006390)2.91383694
89ribosomal large subunit biogenesis (GO:0042273)2.90568614
90CTP metabolic process (GO:0046036)2.84444960
91CTP biosynthetic process (GO:0006241)2.84444960
92ncRNA metabolic process (GO:0034660)2.82161386
93protein-cofactor linkage (GO:0018065)2.82146070
94adenosine metabolic process (GO:0046085)2.81902850
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80902377
96UTP metabolic process (GO:0046051)2.80730499
97ribonucleoprotein complex biogenesis (GO:0022613)2.79300192
98termination of RNA polymerase I transcription (GO:0006363)2.78479353
99protein localization to mitochondrion (GO:0070585)2.77435285
100transcription elongation from RNA polymerase I promoter (GO:0006362)2.76613737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.28266549
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.72725955
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24670678
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.93133234
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29646333
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03470450
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99437531
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.91424208
9VDR_23849224_ChIP-Seq_CD4+_Human2.90361356
10E2F7_22180533_ChIP-Seq_HELA_Human2.85844690
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.84707568
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.81426384
13ELK1_19687146_ChIP-ChIP_HELA_Human2.62505375
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50462552
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46675708
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46541191
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42298988
18FOXP3_21729870_ChIP-Seq_TREG_Human2.42196970
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25839524
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.24689009
21VDR_22108803_ChIP-Seq_LS180_Human2.23893070
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.06496846
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.99763261
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94375573
25ZNF274_21170338_ChIP-Seq_K562_Hela1.91897181
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89056313
27EWS_26573619_Chip-Seq_HEK293_Human1.86860609
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86065704
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83425741
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82778200
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80869031
32DCP1A_22483619_ChIP-Seq_HELA_Human1.78207609
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76425892
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68868231
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62946649
36GABP_19822575_ChIP-Seq_HepG2_Human1.59193015
37MYC_18940864_ChIP-ChIP_HL60_Human1.58566854
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58554218
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58410015
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50896513
41TTF2_22483619_ChIP-Seq_HELA_Human1.50473372
42TP53_22573176_ChIP-Seq_HFKS_Human1.38765111
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38704989
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37781960
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35227801
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32803985
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32062430
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31652603
49FUS_26573619_Chip-Seq_HEK293_Human1.30518734
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.27272218
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26074954
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19736958
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.18742808
54GATA3_26560356_Chip-Seq_TH2_Human1.18641696
55XRN2_22483619_ChIP-Seq_HELA_Human1.18240366
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16910306
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.15676498
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15676498
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11483169
60IGF1R_20145208_ChIP-Seq_DFB_Human1.11358232
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09488426
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07574133
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07506895
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06872688
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.06722040
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06573070
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.06502463
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05417551
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05035844
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04871175
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.04214489
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03482941
73P300_19829295_ChIP-Seq_ESCs_Human1.03387347
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03155270
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.02323905
76SOX2_19829295_ChIP-Seq_ESCs_Human1.00896141
77NANOG_19829295_ChIP-Seq_ESCs_Human1.00896141
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.00891966
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00322535
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99153567
81MYB_26560356_Chip-Seq_TH2_Human0.97937125
82TAF15_26573619_Chip-Seq_HEK293_Human0.97755695
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97483791
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95438716
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95176779
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94167595
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90392391
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89925390
89NCOR_22424771_ChIP-Seq_293T_Human0.88936641
90IRF1_19129219_ChIP-ChIP_H3396_Human0.88744115
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88255063
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87261568
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86793775
94AR_20517297_ChIP-Seq_VCAP_Human0.86068348
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85037203
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84875307
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84581098
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.84115005
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83945014
100ER_23166858_ChIP-Seq_MCF-7_Human0.83739735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.66631778
2MP0004147_increased_porphyrin_level3.33299099
3MP0008877_abnormal_DNA_methylation3.03074634
4MP0000685_abnormal_immune_system2.80489826
5MP0005671_abnormal_response_to2.60609107
6MP0002102_abnormal_ear_morphology2.59631760
7MP0008058_abnormal_DNA_repair2.50997875
8MP0002138_abnormal_hepatobiliary_system2.40336773
9MP0003786_premature_aging2.35563348
10MP0008872_abnormal_physiological_respon2.29203620
11MP0003195_calcinosis2.26491569
12MP0003693_abnormal_embryo_hatching2.25696924
13MP0010094_abnormal_chromosome_stability2.24483142
14MP0008875_abnormal_xenobiotic_pharmacok2.14582707
15MP0004957_abnormal_blastocyst_morpholog2.14238100
16MP0003718_maternal_effect2.07495148
17MP0001873_stomach_inflammation2.01806608
18MP0009785_altered_susceptibility_to1.99823695
19MP0002736_abnormal_nociception_after1.98064932
20MP0003646_muscle_fatigue1.90241789
21MP0002148_abnormal_hypersensitivity_rea1.88726881
22MP0005075_abnormal_melanosome_morpholog1.84066240
23MP0006036_abnormal_mitochondrial_physio1.84020004
24MP0006072_abnormal_retinal_apoptosis1.80086328
25MP0000372_irregular_coat_pigmentation1.75620824
26MP0001790_abnormal_immune_system1.74759330
27MP0005387_immune_system_phenotype1.74759330
28MP0001968_abnormal_touch/_nociception1.74732689
29MP0003806_abnormal_nucleotide_metabolis1.66068367
30MP0008995_early_reproductive_senescence1.64625625
31MP0001800_abnormal_humoral_immune1.59458603
32MP0009333_abnormal_splenocyte_physiolog1.59319544
33MP0006292_abnormal_olfactory_placode1.56422162
34MP0001348_abnormal_lacrimal_gland1.51488932
35MP0002006_tumorigenesis1.50566863
36MP0002277_abnormal_respiratory_mucosa1.48114592
37MP0002166_altered_tumor_susceptibility1.42343944
38MP0003186_abnormal_redox_activity1.41597146
39MP0009697_abnormal_copulation1.39043528
40MP0003567_abnormal_fetal_cardiomyocyte1.38473082
41MP0002837_dystrophic_cardiac_calcinosis1.37618419
42MP0003878_abnormal_ear_physiology1.35919955
43MP0005377_hearing/vestibular/ear_phenot1.35919955
44MP0005645_abnormal_hypothalamus_physiol1.32963296
45MP0008057_abnormal_DNA_replication1.24462640
46MP0001188_hyperpigmentation1.24280125
47MP0005000_abnormal_immune_tolerance1.22678143
48MP0008007_abnormal_cellular_replicative1.22522332
49MP0004782_abnormal_surfactant_physiolog1.21724990
50MP0006035_abnormal_mitochondrial_morpho1.19520867
51MP0001293_anophthalmia1.19310358
52MP0004885_abnormal_endolymph1.18609243
53MP0001661_extended_life_span1.17582243
54MP0003077_abnormal_cell_cycle1.15719018
55MP0004145_abnormal_muscle_electrophysio1.15710853
56MP0005360_urolithiasis1.14930414
57MP0005084_abnormal_gallbladder_morpholo1.14305178
58MP0003763_abnormal_thymus_physiology1.13220307
59MP0005646_abnormal_pituitary_gland1.11955344
60MP0005551_abnormal_eye_electrophysiolog1.09638574
61MP0001853_heart_inflammation1.06895443
62MP0002723_abnormal_immune_serum1.06704008
63MP0000689_abnormal_spleen_morphology1.05943328
64MP0001529_abnormal_vocalization1.03541117
65MP0003111_abnormal_nucleus_morphology1.02164174
66MP0002398_abnormal_bone_marrow1.00523354
67MP0004043_abnormal_pH_regulation1.00505124
68MP0001764_abnormal_homeostasis0.97397219
69MP0002452_abnormal_antigen_presenting0.96463019
70MP0005389_reproductive_system_phenotype0.96093489
71MP0002420_abnormal_adaptive_immunity0.94974521
72MP0000703_abnormal_thymus_morphology0.93554060
73MP0002876_abnormal_thyroid_physiology0.93497503
74MP0002160_abnormal_reproductive_system0.91869390
75MP0001819_abnormal_immune_cell0.91686325
76MP0002735_abnormal_chemical_nociception0.89575803
77MP0002210_abnormal_sex_determination0.89148958
78MP0003724_increased_susceptibility_to0.87783279
79MP0001485_abnormal_pinna_reflex0.87611400
80MP0000716_abnormal_immune_system0.86628292
81MP0002405_respiratory_system_inflammati0.86459497
82MP0005636_abnormal_mineral_homeostasis0.86403503
83MP0005410_abnormal_fertilization0.85910892
84MP0005332_abnormal_amino_acid0.85895823
85MP0003866_abnormal_defecation0.83199246
86MP0002722_abnormal_immune_system0.82009857
87MP0009764_decreased_sensitivity_to0.80942435
88MP0002429_abnormal_blood_cell0.79378361
89MP0005025_abnormal_response_to0.79240342
90MP0010155_abnormal_intestine_physiology0.78528337
91MP0008789_abnormal_olfactory_epithelium0.78418331
92MP0001986_abnormal_taste_sensitivity0.77048775
93MP0005379_endocrine/exocrine_gland_phen0.76688816
94MP0001984_abnormal_olfaction0.76677220
95MP0004142_abnormal_muscle_tone0.76329626
96MP0002938_white_spotting0.75729180
97MP0001929_abnormal_gametogenesis0.75283962
98MP0002019_abnormal_tumor_incidence0.74126224
99MP0003011_delayed_dark_adaptation0.72961940
100MP0001501_abnormal_sleep_pattern0.72874531

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.80387758
2Acute necrotizing encephalopathy (HP:0006965)4.48378919
3Increased CSF lactate (HP:0002490)4.12818770
4Mitochondrial inheritance (HP:0001427)4.11906338
5Acute encephalopathy (HP:0006846)4.07375230
6Abnormality of alanine metabolism (HP:0010916)3.93618018
7Hyperalaninemia (HP:0003348)3.93618018
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.93618018
9Abnormal mitochondria in muscle tissue (HP:0008316)3.89604362
10Progressive macrocephaly (HP:0004481)3.68142293
11Hepatocellular necrosis (HP:0001404)3.59762763
12Increased hepatocellular lipid droplets (HP:0006565)3.57566322
13IgG deficiency (HP:0004315)3.31289513
14Hepatic necrosis (HP:0002605)3.28454612
15Increased serum lactate (HP:0002151)3.22238150
16Aplastic anemia (HP:0001915)3.18803338
17Methylmalonic acidemia (HP:0002912)3.11308808
18Lipid accumulation in hepatocytes (HP:0006561)3.07038345
19Cerebral edema (HP:0002181)3.06568585
20Methylmalonic aciduria (HP:0012120)2.97607220
21Constricted visual fields (HP:0001133)2.92432994
223-Methylglutaconic aciduria (HP:0003535)2.91951005
23Severe combined immunodeficiency (HP:0004430)2.85754950
24Abnormality of serum amino acid levels (HP:0003112)2.81397016
25Lactic acidosis (HP:0003128)2.71216224
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.68304219
27Type 2 muscle fiber atrophy (HP:0003554)2.64221368
28Exertional dyspnea (HP:0002875)2.61643826
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.61391871
30Renal Fanconi syndrome (HP:0001994)2.60879391
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59309434
32Abnormality of midbrain morphology (HP:0002418)2.50369324
33Molar tooth sign on MRI (HP:0002419)2.50369324
34Abnormality of T cell physiology (HP:0011840)2.50029046
35Optic disc pallor (HP:0000543)2.45525021
36Thyroiditis (HP:0100646)2.44913670
37Abnormality of the pons (HP:0007361)2.44688663
38Hyperglycinemia (HP:0002154)2.43047420
39Hypoproteinemia (HP:0003075)2.42947944
40Abnormality of T cells (HP:0002843)2.41550606
41Congenital stationary night blindness (HP:0007642)2.40161754
42Lethargy (HP:0001254)2.39112100
43Increased intramyocellular lipid droplets (HP:0012240)2.36772936
44Increased serum pyruvate (HP:0003542)2.35570638
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27772388
46Combined immunodeficiency (HP:0005387)2.26568500
47Abolished electroretinogram (ERG) (HP:0000550)2.25576065
48Respiratory failure (HP:0002878)2.23703598
49Increased IgM level (HP:0003496)2.21716458
50Pancreatic cysts (HP:0001737)2.21356071
51Hypoplasia of the pons (HP:0012110)2.17961010
52Type I transferrin isoform profile (HP:0003642)2.17757410
53Muscle fiber atrophy (HP:0100295)2.17286945
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16846970
55Exercise intolerance (HP:0003546)2.16522990
56Leukodystrophy (HP:0002415)2.16160723
57Pancytopenia (HP:0001876)2.15519446
58T lymphocytopenia (HP:0005403)2.15072830
59Pendular nystagmus (HP:0012043)2.13036097
60Abnormality of methionine metabolism (HP:0010901)2.09906961
61Elevated erythrocyte sedimentation rate (HP:0003565)2.08942356
62Abnormal rod and cone electroretinograms (HP:0008323)2.08814657
63B lymphocytopenia (HP:0010976)2.08595338
64Nephronophthisis (HP:0000090)2.07855866
65Abnormality of B cell number (HP:0010975)2.07375776
66Testicular atrophy (HP:0000029)2.06886245
67Abnormality of T cell number (HP:0011839)2.05675869
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04359489
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04359489
70Panhypogammaglobulinemia (HP:0003139)2.03329894
71Abnormality of glycolysis (HP:0004366)2.03056166
72Abnormality of the vitamin B12 metabolism (HP:0004341)2.02151089
73Colon cancer (HP:0003003)2.00872765
74Abnormality of glycine metabolism (HP:0010895)1.99020498
75Abnormality of serine family amino acid metabolism (HP:0010894)1.99020498
76IgA deficiency (HP:0002720)1.98219990
77Respiratory difficulties (HP:0002880)1.97826102
78Abnormality of the renal collecting system (HP:0004742)1.93801061
79Neutropenia (HP:0001875)1.93669453
80Congenital, generalized hypertrichosis (HP:0004540)1.92208709
81Duplicated collecting system (HP:0000081)1.91998137
82Attenuation of retinal blood vessels (HP:0007843)1.90827010
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88282181
84Abnormality of the labia minora (HP:0012880)1.87590472
85Abnormality of vitamin B metabolism (HP:0004340)1.87232791
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86319756
87Abnormal protein N-linked glycosylation (HP:0012347)1.86319756
88Abnormal protein glycosylation (HP:0012346)1.86319756
89Abnormal glycosylation (HP:0012345)1.86319756
90Abnormality of the ileum (HP:0001549)1.85267654
91Megaloblastic anemia (HP:0001889)1.84552684
92Meckel diverticulum (HP:0002245)1.81512556
93Hyperglycinuria (HP:0003108)1.80897669
94Cerebral hypomyelination (HP:0006808)1.80417810
95CNS demyelination (HP:0007305)1.78853964
96Abnormality of eosinophils (HP:0001879)1.76041795
97Homocystinuria (HP:0002156)1.75820378
98Abnormality of homocysteine metabolism (HP:0010919)1.75820378
99Abnormality of the prostate (HP:0008775)1.75079232
100Delayed CNS myelination (HP:0002188)1.75011560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.87653950
2MST43.42540506
3VRK23.24128671
4EIF2AK33.20206001
5NUAK13.14162217
6TXK2.53802122
7ZAK2.44717510
8BUB12.43379363
9EIF2AK12.35556822
10SRPK12.31184416
11NEK12.20747757
12PLK32.15103447
13NME12.07934472
14VRK12.05424596
15PBK2.02094217
16MAP4K22.00980293
17ADRBK22.00027120
18MKNK21.89954241
19TLK11.84067426
20MKNK11.83955107
21TAF11.83091376
22WNK41.70684230
23TEC1.67145044
24BMPR1B1.66441760
25TRIM281.65511227
26PLK41.63160145
27EIF2AK21.53788234
28ACVR1B1.50225282
29TAOK31.49423826
30OXSR11.46680624
31GRK11.45897977
32STK391.41230915
33FRK1.40925887
34PDK21.29914089
35STK161.28859522
36PLK21.24019801
37WNK31.22537440
38ITK1.21460156
39PASK1.08097984
40BCR1.05662302
41ALK1.02075582
42MAP3K120.99208539
43TGFBR10.96731262
44BCKDK0.96033743
45CDC70.94233509
46TIE10.88142450
47DAPK10.83593754
48DYRK20.81644192
49PLK10.81488814
50CSNK1G30.75388626
51IKBKB0.72068043
52CSNK1G10.70312607
53ATR0.69355347
54CDK80.69289110
55CSNK1A1L0.67726109
56BRSK20.66562589
57GRK50.65791594
58MAP2K60.63236874
59KDR0.60998606
60SYK0.58133679
61ADRBK10.57094882
62TNIK0.56875312
63MAPKAPK50.56269084
64INSRR0.55163171
65TTK0.54240944
66CSNK1G20.53313688
67SIK30.52870444
68IKBKE0.49138473
69AURKB0.44581998
70RPS6KA50.44424337
71KIT0.44117333
72CSNK2A20.43318363
73JAK30.43269038
74PIK3CG0.43144956
75DAPK20.42810376
76FGFR10.42204996
77WEE10.41265736
78CSNK2A10.41246696
79BTK0.40824620
80LCK0.40173950
81ERBB30.39257758
82IGF1R0.38966769
83STK40.37651668
84FLT30.37082770
85PRKCQ0.36286294
86CDK90.36242772
87STK30.35424005
88PRKCE0.33810478
89CSNK1A10.32345286
90RPS6KA40.31782738
91NLK0.31663072
92PAK40.30230551
93PRKCI0.29930195
94PHKG10.29862189
95PHKG20.29862189
96PAK30.28875119
97PINK10.28630770
98CSNK1E0.28410268
99CCNB10.27357044
100PRKCG0.27040378

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.97812862
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35810098
3Asthma_Homo sapiens_hsa053103.16362548
4Protein export_Homo sapiens_hsa030603.03823167
5RNA polymerase_Homo sapiens_hsa030202.56129736
6Allograft rejection_Homo sapiens_hsa053302.53015359
7Oxidative phosphorylation_Homo sapiens_hsa001902.49551874
8One carbon pool by folate_Homo sapiens_hsa006702.35678648
9Autoimmune thyroid disease_Homo sapiens_hsa053202.32104031
10Primary immunodeficiency_Homo sapiens_hsa053402.27220258
11Parkinsons disease_Homo sapiens_hsa050122.15114167
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.12040499
13Ribosome_Homo sapiens_hsa030101.97761485
14RNA degradation_Homo sapiens_hsa030181.91872549
15RNA transport_Homo sapiens_hsa030131.90808922
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83496411
17Propanoate metabolism_Homo sapiens_hsa006401.81748999
18Type I diabetes mellitus_Homo sapiens_hsa049401.79257178
19Basal transcription factors_Homo sapiens_hsa030221.78703153
20Mismatch repair_Homo sapiens_hsa034301.77605666
21Homologous recombination_Homo sapiens_hsa034401.71751594
22DNA replication_Homo sapiens_hsa030301.69602391
23Graft-versus-host disease_Homo sapiens_hsa053321.65759864
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62015542
25Nucleotide excision repair_Homo sapiens_hsa034201.49217752
26Spliceosome_Homo sapiens_hsa030401.48379633
27Vitamin B6 metabolism_Homo sapiens_hsa007501.47602654
28Non-homologous end-joining_Homo sapiens_hsa034501.44897235
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41025110
30Sulfur metabolism_Homo sapiens_hsa009201.41004226
31Pyrimidine metabolism_Homo sapiens_hsa002401.39866536
32Huntingtons disease_Homo sapiens_hsa050161.35384724
33Fanconi anemia pathway_Homo sapiens_hsa034601.31331474
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.29067069
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28472574
36Antigen processing and presentation_Homo sapiens_hsa046121.26424698
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25635417
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24616161
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23941223
40Purine metabolism_Homo sapiens_hsa002301.21462713
41Alzheimers disease_Homo sapiens_hsa050101.16811778
42Hematopoietic cell lineage_Homo sapiens_hsa046401.06335891
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05936192
44Base excision repair_Homo sapiens_hsa034101.01231228
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98309367
46Rheumatoid arthritis_Homo sapiens_hsa053230.96883676
47Linoleic acid metabolism_Homo sapiens_hsa005910.96286797
48Phototransduction_Homo sapiens_hsa047440.91139650
49Selenocompound metabolism_Homo sapiens_hsa004500.85302111
50Butanoate metabolism_Homo sapiens_hsa006500.82580742
51Nitrogen metabolism_Homo sapiens_hsa009100.82394892
52Peroxisome_Homo sapiens_hsa041460.80522369
53Caffeine metabolism_Homo sapiens_hsa002320.79761728
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77974039
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76844501
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72840429
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71128734
58Pyruvate metabolism_Homo sapiens_hsa006200.69817731
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69647591
60Regulation of autophagy_Homo sapiens_hsa041400.69133061
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67870930
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.61797817
63Tryptophan metabolism_Homo sapiens_hsa003800.61217809
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60939161
65Metabolic pathways_Homo sapiens_hsa011000.58701902
66mRNA surveillance pathway_Homo sapiens_hsa030150.56250946
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54843000
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54198247
69Epstein-Barr virus infection_Homo sapiens_hsa051690.53698841
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52833896
71T cell receptor signaling pathway_Homo sapiens_hsa046600.52117158
72Collecting duct acid secretion_Homo sapiens_hsa049660.51807479
73Cardiac muscle contraction_Homo sapiens_hsa042600.50948258
74Retinol metabolism_Homo sapiens_hsa008300.50477314
75Ether lipid metabolism_Homo sapiens_hsa005650.48021615
76beta-Alanine metabolism_Homo sapiens_hsa004100.47824690
77Viral myocarditis_Homo sapiens_hsa054160.46643745
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44401280
79Systemic lupus erythematosus_Homo sapiens_hsa053220.43945845
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43236685
81Arachidonic acid metabolism_Homo sapiens_hsa005900.39919926
82Measles_Homo sapiens_hsa051620.39274719
83p53 signaling pathway_Homo sapiens_hsa041150.37635504
84Glutathione metabolism_Homo sapiens_hsa004800.36159815
85Carbon metabolism_Homo sapiens_hsa012000.33569729
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.31067408
87Cell cycle_Homo sapiens_hsa041100.30783910
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30585573
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30469290
90Olfactory transduction_Homo sapiens_hsa047400.30369455
91Fatty acid elongation_Homo sapiens_hsa000620.29551050
92Herpes simplex infection_Homo sapiens_hsa051680.29287078
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.29254995
94Chemical carcinogenesis_Homo sapiens_hsa052040.28325566
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.28258675
96Fat digestion and absorption_Homo sapiens_hsa049750.27550862
97Vitamin digestion and absorption_Homo sapiens_hsa049770.25032639
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24342582
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23411445
100Steroid biosynthesis_Homo sapiens_hsa001000.20212918

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