NPM1P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.63283740
2proteasome assembly (GO:0043248)4.96145720
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86844257
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.75482276
5rRNA modification (GO:0000154)4.73037053
6ATP synthesis coupled proton transport (GO:0015986)4.57608038
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57608038
8water-soluble vitamin biosynthetic process (GO:0042364)4.35185881
9chaperone-mediated protein transport (GO:0072321)4.27698533
10exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.20490509
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.14590476
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.12183103
13maturation of 5.8S rRNA (GO:0000460)4.01886633
14rRNA methylation (GO:0031167)3.92344862
15pseudouridine synthesis (GO:0001522)3.86770760
16RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.85924608
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82062477
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.82062477
19NADH dehydrogenase complex assembly (GO:0010257)3.82062477
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77964596
21regulation of cellular amino acid metabolic process (GO:0006521)3.76661048
22protein complex biogenesis (GO:0070271)3.73545035
23mitochondrial respiratory chain complex assembly (GO:0033108)3.71442887
24ribosomal small subunit assembly (GO:0000028)3.71287970
25DNA catabolic process, exonucleolytic (GO:0000738)3.71208213
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70557549
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70402160
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.69623784
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66205080
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65981402
31negative regulation of ligase activity (GO:0051352)3.65981402
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65049097
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65049097
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65049097
35respiratory chain complex IV assembly (GO:0008535)3.61026385
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60777442
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60777442
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.54316916
39termination of RNA polymerase III transcription (GO:0006386)3.54316916
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46914825
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.46914825
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45131210
43cullin deneddylation (GO:0010388)3.41461497
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.40915710
45ribosome assembly (GO:0042255)3.39831691
46respiratory electron transport chain (GO:0022904)3.38802568
47electron transport chain (GO:0022900)3.35268965
48platelet dense granule organization (GO:0060155)3.35219007
49DNA double-strand break processing (GO:0000729)3.33823381
50cytidine metabolic process (GO:0046087)3.28169523
51cytidine catabolic process (GO:0006216)3.28169523
52cytidine deamination (GO:0009972)3.28169523
53ribosomal large subunit biogenesis (GO:0042273)3.22865913
54chromatin remodeling at centromere (GO:0031055)3.21919709
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21292140
56CENP-A containing nucleosome assembly (GO:0034080)3.19109583
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16189042
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16189042
59protein deneddylation (GO:0000338)3.10436205
60positive regulation of ligase activity (GO:0051351)3.06229006
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.06211160
62regulation of immunoglobulin secretion (GO:0051023)3.04603705
63cytochrome complex assembly (GO:0017004)3.04106710
64protein K6-linked ubiquitination (GO:0085020)3.04091404
65protein neddylation (GO:0045116)3.00132264
66regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.95505088
67rRNA processing (GO:0006364)2.94648157
68kynurenine metabolic process (GO:0070189)2.93412695
69IMP biosynthetic process (GO:0006188)2.93335026
70cellular response to interferon-beta (GO:0035458)2.93039340
71spliceosomal snRNP assembly (GO:0000387)2.91053414
72rRNA metabolic process (GO:0016072)2.89956325
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88965213
74maturation of SSU-rRNA (GO:0030490)2.87455344
75GTP biosynthetic process (GO:0006183)2.85604191
76regulation of regulatory T cell differentiation (GO:0045589)2.83971467
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.83564619
78regulation of chronic inflammatory response (GO:0002676)2.82401768
79positive regulation of cell cycle arrest (GO:0071158)2.80067612
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.76765838
81pyrimidine ribonucleoside catabolic process (GO:0046133)2.76464204
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.74171513
83regulation of ubiquitin-protein transferase activity (GO:0051438)2.72726211
84translation (GO:0006412)2.72142645
85regulation of cellular amine metabolic process (GO:0033238)2.68226259
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68168104
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68168104
88isotype switching (GO:0045190)2.68168104
89tRNA processing (GO:0008033)2.68116670
90rRNA catabolic process (GO:0016075)2.67572035
91termination of RNA polymerase I transcription (GO:0006363)2.65518045
92folic acid-containing compound biosynthetic process (GO:0009396)2.65175908
93regulation of ligase activity (GO:0051340)2.62184944
94mitochondrial RNA metabolic process (GO:0000959)2.60462435
95telomere maintenance via semi-conservative replication (GO:0032201)2.60394959
96histone exchange (GO:0043486)2.59748007
97preassembly of GPI anchor in ER membrane (GO:0016254)2.59397184
98RNA phosphodiester bond hydrolysis (GO:0090501)2.59282401
99cellular component biogenesis (GO:0044085)2.59208521
100regulation of mitochondrial translation (GO:0070129)2.58361568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.00559583
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.48060890
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.12431767
4VDR_22108803_ChIP-Seq_LS180_Human3.14478397
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09559655
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02846825
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02235470
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95403036
9E2F7_22180533_ChIP-Seq_HELA_Human2.91389685
10VDR_23849224_ChIP-Seq_CD4+_Human2.85814207
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84726547
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.71135414
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.67834101
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63426729
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63351478
16ZNF274_21170338_ChIP-Seq_K562_Hela2.55928474
17ELK1_19687146_ChIP-ChIP_HELA_Human2.55061733
18FOXP3_21729870_ChIP-Seq_TREG_Human2.49202898
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39595290
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.30706920
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.15342665
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11137568
23EWS_26573619_Chip-Seq_HEK293_Human1.93951755
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88852170
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87656274
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82039338
27MYC_18940864_ChIP-ChIP_HL60_Human1.80992306
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79854823
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78696875
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68307642
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67819403
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62907309
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62235198
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61040802
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59960100
36TTF2_22483619_ChIP-Seq_HELA_Human1.58927211
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.58199022
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.54545310
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53164208
40DCP1A_22483619_ChIP-Seq_HELA_Human1.47008978
41IGF1R_20145208_ChIP-Seq_DFB_Human1.45873819
42FUS_26573619_Chip-Seq_HEK293_Human1.44957383
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44351339
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42852880
45TP53_22573176_ChIP-Seq_HFKS_Human1.42590511
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.39752473
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36810812
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36691978
49GABP_19822575_ChIP-Seq_HepG2_Human1.34550188
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34354992
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32733322
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.32691127
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32691127
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29595245
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29157688
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26168585
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23487288
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20716635
59GATA3_26560356_Chip-Seq_TH2_Human1.17861889
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.16684874
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15055980
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14822794
63SOX2_19829295_ChIP-Seq_ESCs_Human1.13083085
64NANOG_19829295_ChIP-Seq_ESCs_Human1.13083085
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10829773
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.10255597
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10192733
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09557783
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09468019
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09322213
71AR_20517297_ChIP-Seq_VCAP_Human1.08935957
72XRN2_22483619_ChIP-Seq_HELA_Human1.08670769
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07419629
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07392650
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07064973
76P300_19829295_ChIP-Seq_ESCs_Human1.07055602
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05901723
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05858312
79ER_23166858_ChIP-Seq_MCF-7_Human1.05364231
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05091125
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04931172
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02819537
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.00047696
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99620205
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98775603
86IRF1_19129219_ChIP-ChIP_H3396_Human0.98751427
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98417263
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96390468
89IRF8_21731497_ChIP-ChIP_J774_Mouse0.94452414
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90987016
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89913755
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88897923
93TAF15_26573619_Chip-Seq_HEK293_Human0.87769629
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87087911
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.85524709
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.83632144
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83555938
98NCOR_22424771_ChIP-Seq_293T_Human0.82997886
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82509427
100CBP_20019798_ChIP-Seq_JUKART_Human0.82376033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.66449313
2MP0001835_abnormal_antigen_presentation3.45663007
3MP0008058_abnormal_DNA_repair2.67827170
4MP0002837_dystrophic_cardiac_calcinosis2.59940288
5MP0010094_abnormal_chromosome_stability2.49408131
6MP0003786_premature_aging2.46814552
7MP0003693_abnormal_embryo_hatching2.44897079
8MP0006072_abnormal_retinal_apoptosis2.41632818
9MP0003718_maternal_effect2.38326059
10MP0002138_abnormal_hepatobiliary_system2.32636580
11MP0005671_abnormal_response_to2.29686219
12MP0008872_abnormal_physiological_respon2.28948336
13MP0006036_abnormal_mitochondrial_physio2.24964877
14MP0005084_abnormal_gallbladder_morpholo2.22575253
15MP0008877_abnormal_DNA_methylation2.02864624
16MP0004957_abnormal_blastocyst_morpholog2.00992172
17MP0001853_heart_inflammation1.92779170
18MP0006035_abnormal_mitochondrial_morpho1.90895648
19MP0008875_abnormal_xenobiotic_pharmacok1.85350936
20MP0001968_abnormal_touch/_nociception1.76596718
21MP0002148_abnormal_hypersensitivity_rea1.74202779
22MP0002102_abnormal_ear_morphology1.72486124
23MP0005645_abnormal_hypothalamus_physiol1.72284359
24MP0003195_calcinosis1.69866694
25MP0000685_abnormal_immune_system1.68380787
26MP0002006_tumorigenesis1.62891947
27MP0009697_abnormal_copulation1.61121810
28MP0004145_abnormal_muscle_electrophysio1.60269012
29MP0009379_abnormal_foot_pigmentation1.59975021
30MP0002736_abnormal_nociception_after1.59012166
31MP0006292_abnormal_olfactory_placode1.50022024
32MP0008007_abnormal_cellular_replicative1.49080320
33MP0003646_muscle_fatigue1.47416798
34MP0002166_altered_tumor_susceptibility1.46225272
35MP0005646_abnormal_pituitary_gland1.45490960
36MP0003111_abnormal_nucleus_morphology1.38782166
37MP0002163_abnormal_gland_morphology1.35771381
38MP0009785_altered_susceptibility_to1.34278235
39MP0003077_abnormal_cell_cycle1.33561754
40MP0005551_abnormal_eye_electrophysiolog1.32250593
41MP0001800_abnormal_humoral_immune1.31690433
42MP0004147_increased_porphyrin_level1.31611741
43MP0003186_abnormal_redox_activity1.30271710
44MP0009333_abnormal_splenocyte_physiolog1.23103289
45MP0004142_abnormal_muscle_tone1.21975237
46MP0001873_stomach_inflammation1.21607694
47MP0003567_abnormal_fetal_cardiomyocyte1.17779165
48MP0001293_anophthalmia1.17656880
49MP0005379_endocrine/exocrine_gland_phen1.17184302
50MP0004885_abnormal_endolymph1.13565728
51MP0001790_abnormal_immune_system1.12799017
52MP0005387_immune_system_phenotype1.12799017
53MP0002876_abnormal_thyroid_physiology1.08975891
54MP0004215_abnormal_myocardial_fiber1.08437875
55MP0005000_abnormal_immune_tolerance1.07714430
56MP0005389_reproductive_system_phenotype1.05889409
57MP0005075_abnormal_melanosome_morpholog1.05376840
58MP0001485_abnormal_pinna_reflex1.05155108
59MP0005410_abnormal_fertilization1.04534036
60MP0005636_abnormal_mineral_homeostasis1.02584897
61MP0002254_reproductive_system_inflammat1.02584430
62MP0003866_abnormal_defecation0.99826701
63MP0005253_abnormal_eye_physiology0.99355036
64MP0000689_abnormal_spleen_morphology0.98958182
65MP0002693_abnormal_pancreas_physiology0.98238631
66MP0002160_abnormal_reproductive_system0.97520958
67MP0001905_abnormal_dopamine_level0.97293196
68MP0001529_abnormal_vocalization0.96832817
69MP0002723_abnormal_immune_serum0.96798085
70MP0003011_delayed_dark_adaptation0.96335845
71MP0009764_decreased_sensitivity_to0.94728518
72MP0002452_abnormal_antigen_presenting0.94014752
73MP0001919_abnormal_reproductive_system0.93687970
74MP0000383_abnormal_hair_follicle0.92562359
75MP0002420_abnormal_adaptive_immunity0.92341449
76MP0001819_abnormal_immune_cell0.91616637
77MP0000372_irregular_coat_pigmentation0.91069629
78MP0000427_abnormal_hair_cycle0.89980942
79MP0002398_abnormal_bone_marrow0.89527286
80MP0001929_abnormal_gametogenesis0.89230690
81MP0002277_abnormal_respiratory_mucosa0.88641899
82MP0001501_abnormal_sleep_pattern0.87716767
83MP0001986_abnormal_taste_sensitivity0.84698172
84MP0002210_abnormal_sex_determination0.81875388
85MP0005085_abnormal_gallbladder_physiolo0.80655073
86MP0001119_abnormal_female_reproductive0.79413068
87MP0008789_abnormal_olfactory_epithelium0.79255710
88MP0000716_abnormal_immune_system0.77608335
89MP0005167_abnormal_blood-brain_barrier0.77487101
90MP0005220_abnormal_exocrine_pancreas0.76714770
91MP0000653_abnormal_sex_gland0.76578717
92MP0002019_abnormal_tumor_incidence0.76181937
93MP0008995_early_reproductive_senescence0.74697395
94MP0001145_abnormal_male_reproductive0.74475951
95MP0002272_abnormal_nervous_system0.74337202
96MP0000703_abnormal_thymus_morphology0.74164033
97MP0005395_other_phenotype0.73846795
98MP0003252_abnormal_bile_duct0.72724870
99MP0002751_abnormal_autonomic_nervous0.72414897
100MP0002396_abnormal_hematopoietic_system0.71368695

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.35177070
2Mitochondrial inheritance (HP:0001427)4.02743639
3Acute encephalopathy (HP:0006846)3.93415139
4Increased CSF lactate (HP:0002490)3.92139575
5Increased hepatocellular lipid droplets (HP:0006565)3.87829127
6Abnormal mitochondria in muscle tissue (HP:0008316)3.81712772
7Lipid accumulation in hepatocytes (HP:0006561)3.71606497
8Progressive macrocephaly (HP:0004481)3.70321281
9Methylmalonic acidemia (HP:0002912)3.64480737
10Hepatocellular necrosis (HP:0001404)3.51838106
11Aplastic anemia (HP:0001915)3.35403868
123-Methylglutaconic aciduria (HP:0003535)3.31113317
13Elevated erythrocyte sedimentation rate (HP:0003565)3.29811934
14Hepatic necrosis (HP:0002605)3.23578580
15Abnormality of alanine metabolism (HP:0010916)3.21500984
16Hyperalaninemia (HP:0003348)3.21500984
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.21500984
18Methylmalonic aciduria (HP:0012120)3.16457275
19Increased serum lactate (HP:0002151)3.08433125
20Colon cancer (HP:0003003)3.06348001
21Abnormality of B cell number (HP:0010975)2.98432423
22IgG deficiency (HP:0004315)2.93117790
23Congenital, generalized hypertrichosis (HP:0004540)2.84436790
24Cerebral edema (HP:0002181)2.83776890
25Stomatitis (HP:0010280)2.79203497
26Congenital stationary night blindness (HP:0007642)2.78857711
27Renal Fanconi syndrome (HP:0001994)2.73600890
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72615663
29Exertional dyspnea (HP:0002875)2.61103946
30Abolished electroretinogram (ERG) (HP:0000550)2.59129839
31Pancreatic cysts (HP:0001737)2.56552206
32Lactic acidosis (HP:0003128)2.51843514
33Optic disc pallor (HP:0000543)2.50027480
34Stomach cancer (HP:0012126)2.46469617
35Panhypogammaglobulinemia (HP:0003139)2.44163669
36Oral leukoplakia (HP:0002745)2.39190809
37Pancytopenia (HP:0001876)2.38025184
38Abnormality of midbrain morphology (HP:0002418)2.36436769
39Molar tooth sign on MRI (HP:0002419)2.36436769
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.35838560
41Increased intramyocellular lipid droplets (HP:0012240)2.35661480
42Abnormality of T cell physiology (HP:0011840)2.35183895
43Nephronophthisis (HP:0000090)2.34913685
44Respiratory failure (HP:0002878)2.34328772
45Abnormality of serum amino acid levels (HP:0003112)2.32050251
46Abnormality of the renal cortex (HP:0011035)2.31129192
47Abnormality of vitamin B metabolism (HP:0004340)2.29655678
48Hypoproteinemia (HP:0003075)2.24411578
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24212596
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23772686
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21661621
52Lethargy (HP:0001254)2.18251728
53Supernumerary spleens (HP:0009799)2.18182621
54Abnormality of the renal medulla (HP:0100957)2.16325559
55Meckel diverticulum (HP:0002245)2.14838813
56Abnormality of the ileum (HP:0001549)2.14531154
57Poor head control (HP:0002421)2.13906328
58Abnormality of the pons (HP:0007361)2.13407540
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.13277505
60B lymphocytopenia (HP:0010976)2.12387365
61Leukodystrophy (HP:0002415)2.11751100
62Exercise intolerance (HP:0003546)2.10918623
63Abnormal number of erythroid precursors (HP:0012131)2.09602853
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.07538396
65Pancreatic fibrosis (HP:0100732)2.05988372
66Abnormality of T cells (HP:0002843)2.04080586
67Pendular nystagmus (HP:0012043)2.03234864
68Abnormal rod and cone electroretinograms (HP:0008323)2.02512260
69Severe combined immunodeficiency (HP:0004430)2.02136955
70Abnormality of the labia minora (HP:0012880)2.02129001
71Bile duct proliferation (HP:0001408)2.01943078
72Abnormal biliary tract physiology (HP:0012439)2.01943078
73Clubbing of toes (HP:0100760)2.01326132
74Hyperglycinuria (HP:0003108)2.00907947
75IgM deficiency (HP:0002850)2.00429711
76Renal cortical cysts (HP:0000803)2.00268802
77Eosinophilia (HP:0001880)1.99790563
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99441518
79Abnormality of the preputium (HP:0100587)1.98835131
80Increased muscle lipid content (HP:0009058)1.97485664
81True hermaphroditism (HP:0010459)1.97337059
82Cleft eyelid (HP:0000625)1.95633412
83Hyperglycinemia (HP:0002154)1.94852656
84Testicular atrophy (HP:0000029)1.94087717
85Dicarboxylic aciduria (HP:0003215)1.92485043
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92485043
87Aplasia/hypoplasia of the uterus (HP:0008684)1.92450892
88Abnormality of urine glucose concentration (HP:0011016)1.92271645
89Glycosuria (HP:0003076)1.92271645
90Abnormality of methionine metabolism (HP:0010901)1.91994488
91Abnormality of glycine metabolism (HP:0010895)1.91577003
92Abnormality of serine family amino acid metabolism (HP:0010894)1.91577003
93Thyroiditis (HP:0100646)1.90648043
94Macrocytic anemia (HP:0001972)1.90105379
95Type 2 muscle fiber atrophy (HP:0003554)1.89322739
96Attenuation of retinal blood vessels (HP:0007843)1.89191774
97Hypoplasia of the pons (HP:0012110)1.88098429
98Constricted visual fields (HP:0001133)1.88033515
99Duplicated collecting system (HP:0000081)1.87610081
100Abnormality of the renal collecting system (HP:0004742)1.87595624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.36525110
2EIF2AK33.30889160
3BUB13.29083704
4MST43.28975092
5NUAK13.01568062
6ZAK2.90539966
7TSSK62.53248915
8TLK12.53013650
9NEK12.23436454
10STK162.16365424
11EIF2AK12.15938711
12VRK12.15130107
13TAOK32.07995274
14PBK2.04288588
15MKNK21.95042483
16PLK31.92184674
17TXK1.80905604
18BMPR1B1.77939545
19MKNK11.76958812
20TRIM281.74983045
21ADRBK21.66841841
22OXSR11.66482112
23MAP4K21.64947672
24FRK1.64592231
25GRK11.61936736
26TEC1.55593419
27MAP2K61.47065565
28PASK1.43243522
29PLK41.42370047
30STK391.38268504
31NME11.38197423
32PLK21.37713940
33TAF11.36001892
34SRPK11.35294692
35PINK11.34483130
36WNK31.33368547
37WNK41.31617668
38EIF2AK21.28848330
39BCKDK1.15815153
40INSRR1.03755533
41CDK81.01282002
42ITK0.98183948
43CDC70.97487830
44TGFBR10.94618617
45KIT0.88570142
46RPS6KA50.86395587
47TTK0.84300344
48ALK0.81582712
49PLK10.78832462
50ERBB30.76946934
51ATR0.75262703
52DAPK10.72815323
53STK38L0.71097838
54BMPR20.69224849
55DYRK20.69185273
56PRKCE0.68239192
57MAP3K120.67561565
58WEE10.63234658
59PRKCQ0.61803533
60IKBKB0.61318815
61GRK50.60579607
62AURKB0.59937862
63CSNK1G30.59086942
64PRKCI0.58209757
65NLK0.57089186
66CSNK1G10.56818158
67NME20.56537204
68MAP4K10.55674565
69ACVR1B0.53386313
70PHKG10.53340869
71PHKG20.53340869
72MYLK0.53246161
73DAPK20.52603178
74TIE10.52577706
75PIK3CG0.52040489
76CSNK1A1L0.51207702
77CSNK1G20.49190642
78RPS6KA40.48661774
79KDR0.45911368
80SYK0.42384959
81CSNK2A10.41591537
82FLT30.41415037
83EPHA30.39329304
84ADRBK10.39293269
85PRKCG0.39147161
86IRAK10.38713217
87CDK190.38328662
88CHEK20.37316672
89MAPKAPK50.37079731
90STK40.36000671
91BTK0.35653667
92CSNK2A20.35609951
93LYN0.33481905
94LCK0.33294908
95BRSK20.33293619
96ILK0.31414171
97STK30.31039936
98DAPK30.30148542
99PDK20.28689047
100IGF1R0.26471411

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.72623901
2Oxidative phosphorylation_Homo sapiens_hsa001902.99891592
3Protein export_Homo sapiens_hsa030602.97597669
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76690577
5Ribosome_Homo sapiens_hsa030102.67707115
6Asthma_Homo sapiens_hsa053102.66928118
7RNA polymerase_Homo sapiens_hsa030202.65148823
8Parkinsons disease_Homo sapiens_hsa050122.54460957
9One carbon pool by folate_Homo sapiens_hsa006702.28906610
10DNA replication_Homo sapiens_hsa030302.20262326
11Mismatch repair_Homo sapiens_hsa034302.17463609
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.16783465
13RNA degradation_Homo sapiens_hsa030182.11180511
14Allograft rejection_Homo sapiens_hsa053302.09994805
15Autoimmune thyroid disease_Homo sapiens_hsa053202.06423664
16Primary immunodeficiency_Homo sapiens_hsa053401.94139845
17Homologous recombination_Homo sapiens_hsa034401.93139817
18Graft-versus-host disease_Homo sapiens_hsa053321.87930673
19Type I diabetes mellitus_Homo sapiens_hsa049401.80793993
20Basal transcription factors_Homo sapiens_hsa030221.69766934
21Spliceosome_Homo sapiens_hsa030401.66558554
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66393130
23Huntingtons disease_Homo sapiens_hsa050161.65402877
24RNA transport_Homo sapiens_hsa030131.63117250
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57556680
26Propanoate metabolism_Homo sapiens_hsa006401.56511287
27Alzheimers disease_Homo sapiens_hsa050101.56011460
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54812004
29Fanconi anemia pathway_Homo sapiens_hsa034601.54424470
30Antigen processing and presentation_Homo sapiens_hsa046121.53268885
31Pyrimidine metabolism_Homo sapiens_hsa002401.46486943
32Base excision repair_Homo sapiens_hsa034101.45218510
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34432795
34Non-homologous end-joining_Homo sapiens_hsa034501.34369997
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33947602
36Nucleotide excision repair_Homo sapiens_hsa034201.33210868
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32139365
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16929288
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14765344
40Purine metabolism_Homo sapiens_hsa002301.12535785
41Nitrogen metabolism_Homo sapiens_hsa009101.09677343
42Linoleic acid metabolism_Homo sapiens_hsa005911.07983637
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95953450
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.94268400
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92408359
46Caffeine metabolism_Homo sapiens_hsa002320.91320304
47Phototransduction_Homo sapiens_hsa047440.87313712
48Tryptophan metabolism_Homo sapiens_hsa003800.85288246
49Sulfur metabolism_Homo sapiens_hsa009200.83155339
50Peroxisome_Homo sapiens_hsa041460.82331470
51Pyruvate metabolism_Homo sapiens_hsa006200.77807061
52Rheumatoid arthritis_Homo sapiens_hsa053230.77404220
53Glutathione metabolism_Homo sapiens_hsa004800.75881084
54Butanoate metabolism_Homo sapiens_hsa006500.75780741
55Systemic lupus erythematosus_Homo sapiens_hsa053220.75428718
56Cardiac muscle contraction_Homo sapiens_hsa042600.71952640
57Hematopoietic cell lineage_Homo sapiens_hsa046400.71883308
58Ether lipid metabolism_Homo sapiens_hsa005650.66470737
59Retinol metabolism_Homo sapiens_hsa008300.65602633
60Arachidonic acid metabolism_Homo sapiens_hsa005900.62518762
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62063830
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61707592
63Metabolic pathways_Homo sapiens_hsa011000.60441527
64Folate biosynthesis_Homo sapiens_hsa007900.59535947
65Chemical carcinogenesis_Homo sapiens_hsa052040.59303931
66p53 signaling pathway_Homo sapiens_hsa041150.58583042
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55984781
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.52654809
69Epstein-Barr virus infection_Homo sapiens_hsa051690.52047363
70Selenocompound metabolism_Homo sapiens_hsa004500.51847821
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51660158
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49877652
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.49457486
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48379678
75Collecting duct acid secretion_Homo sapiens_hsa049660.47420778
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46327794
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46076105
78Fatty acid elongation_Homo sapiens_hsa000620.45993801
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43479719
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42605689
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42534906
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.42041443
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41642778
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41043987
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.40803786
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40637014
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39870272
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.39806421
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37588842
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37411530
91Vitamin B6 metabolism_Homo sapiens_hsa007500.37013749
92Regulation of autophagy_Homo sapiens_hsa041400.35819751
93Cell cycle_Homo sapiens_hsa041100.34213978
94Fat digestion and absorption_Homo sapiens_hsa049750.34154374
95beta-Alanine metabolism_Homo sapiens_hsa004100.31527207
96T cell receptor signaling pathway_Homo sapiens_hsa046600.29888791
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28864486
98Arginine and proline metabolism_Homo sapiens_hsa003300.26430502
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.26080649
100Fatty acid degradation_Homo sapiens_hsa000710.25189006

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