

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.63283740 |
| 2 | proteasome assembly (GO:0043248) | 4.96145720 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.86844257 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.75482276 |
| 5 | rRNA modification (GO:0000154) | 4.73037053 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.57608038 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.57608038 |
| 8 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.35185881 |
| 9 | chaperone-mediated protein transport (GO:0072321) | 4.27698533 |
| 10 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.20490509 |
| 11 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.14590476 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.12183103 |
| 13 | maturation of 5.8S rRNA (GO:0000460) | 4.01886633 |
| 14 | rRNA methylation (GO:0031167) | 3.92344862 |
| 15 | pseudouridine synthesis (GO:0001522) | 3.86770760 |
| 16 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.85924608 |
| 17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.82062477 |
| 18 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.82062477 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 3.82062477 |
| 20 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.77964596 |
| 21 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.76661048 |
| 22 | protein complex biogenesis (GO:0070271) | 3.73545035 |
| 23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.71442887 |
| 24 | ribosomal small subunit assembly (GO:0000028) | 3.71287970 |
| 25 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.71208213 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.70557549 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.70402160 |
| 28 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.69623784 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.66205080 |
| 30 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.65981402 |
| 31 | negative regulation of ligase activity (GO:0051352) | 3.65981402 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.65049097 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.65049097 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.65049097 |
| 35 | respiratory chain complex IV assembly (GO:0008535) | 3.61026385 |
| 36 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.60777442 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.60777442 |
| 38 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.54316916 |
| 39 | termination of RNA polymerase III transcription (GO:0006386) | 3.54316916 |
| 40 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.46914825 |
| 41 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.46914825 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.45131210 |
| 43 | cullin deneddylation (GO:0010388) | 3.41461497 |
| 44 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40915710 |
| 45 | ribosome assembly (GO:0042255) | 3.39831691 |
| 46 | respiratory electron transport chain (GO:0022904) | 3.38802568 |
| 47 | electron transport chain (GO:0022900) | 3.35268965 |
| 48 | platelet dense granule organization (GO:0060155) | 3.35219007 |
| 49 | DNA double-strand break processing (GO:0000729) | 3.33823381 |
| 50 | cytidine metabolic process (GO:0046087) | 3.28169523 |
| 51 | cytidine catabolic process (GO:0006216) | 3.28169523 |
| 52 | cytidine deamination (GO:0009972) | 3.28169523 |
| 53 | ribosomal large subunit biogenesis (GO:0042273) | 3.22865913 |
| 54 | chromatin remodeling at centromere (GO:0031055) | 3.21919709 |
| 55 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.21292140 |
| 56 | CENP-A containing nucleosome assembly (GO:0034080) | 3.19109583 |
| 57 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.16189042 |
| 58 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.16189042 |
| 59 | protein deneddylation (GO:0000338) | 3.10436205 |
| 60 | positive regulation of ligase activity (GO:0051351) | 3.06229006 |
| 61 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.06211160 |
| 62 | regulation of immunoglobulin secretion (GO:0051023) | 3.04603705 |
| 63 | cytochrome complex assembly (GO:0017004) | 3.04106710 |
| 64 | protein K6-linked ubiquitination (GO:0085020) | 3.04091404 |
| 65 | protein neddylation (GO:0045116) | 3.00132264 |
| 66 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.95505088 |
| 67 | rRNA processing (GO:0006364) | 2.94648157 |
| 68 | kynurenine metabolic process (GO:0070189) | 2.93412695 |
| 69 | IMP biosynthetic process (GO:0006188) | 2.93335026 |
| 70 | cellular response to interferon-beta (GO:0035458) | 2.93039340 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 2.91053414 |
| 72 | rRNA metabolic process (GO:0016072) | 2.89956325 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.88965213 |
| 74 | maturation of SSU-rRNA (GO:0030490) | 2.87455344 |
| 75 | GTP biosynthetic process (GO:0006183) | 2.85604191 |
| 76 | regulation of regulatory T cell differentiation (GO:0045589) | 2.83971467 |
| 77 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.83564619 |
| 78 | regulation of chronic inflammatory response (GO:0002676) | 2.82401768 |
| 79 | positive regulation of cell cycle arrest (GO:0071158) | 2.80067612 |
| 80 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.76765838 |
| 81 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.76464204 |
| 82 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.74171513 |
| 83 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.72726211 |
| 84 | translation (GO:0006412) | 2.72142645 |
| 85 | regulation of cellular amine metabolic process (GO:0033238) | 2.68226259 |
| 86 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.68168104 |
| 87 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.68168104 |
| 88 | isotype switching (GO:0045190) | 2.68168104 |
| 89 | tRNA processing (GO:0008033) | 2.68116670 |
| 90 | rRNA catabolic process (GO:0016075) | 2.67572035 |
| 91 | termination of RNA polymerase I transcription (GO:0006363) | 2.65518045 |
| 92 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.65175908 |
| 93 | regulation of ligase activity (GO:0051340) | 2.62184944 |
| 94 | mitochondrial RNA metabolic process (GO:0000959) | 2.60462435 |
| 95 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.60394959 |
| 96 | histone exchange (GO:0043486) | 2.59748007 |
| 97 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.59397184 |
| 98 | RNA phosphodiester bond hydrolysis (GO:0090501) | 2.59282401 |
| 99 | cellular component biogenesis (GO:0044085) | 2.59208521 |
| 100 | regulation of mitochondrial translation (GO:0070129) | 2.58361568 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.00559583 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.48060890 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.12431767 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.14478397 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.09559655 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.02846825 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.02235470 |
| 8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.95403036 |
| 9 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.91389685 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.85814207 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.84726547 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.71135414 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.67834101 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.63426729 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.63351478 |
| 16 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.55928474 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.55061733 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.49202898 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.39595290 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.30706920 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.15342665 |
| 22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.11137568 |
| 23 | EWS_26573619_Chip-Seq_HEK293_Human | 1.93951755 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.88852170 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.87656274 |
| 26 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.82039338 |
| 27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80992306 |
| 28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.79854823 |
| 29 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.78696875 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68307642 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.67819403 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.62907309 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.62235198 |
| 34 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.61040802 |
| 35 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.59960100 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.58927211 |
| 37 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.58199022 |
| 38 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.54545310 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53164208 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.47008978 |
| 41 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.45873819 |
| 42 | FUS_26573619_Chip-Seq_HEK293_Human | 1.44957383 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.44351339 |
| 44 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.42852880 |
| 45 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.42590511 |
| 46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.39752473 |
| 47 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.36810812 |
| 48 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.36691978 |
| 49 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.34550188 |
| 50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.34354992 |
| 51 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.32733322 |
| 52 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.32691127 |
| 53 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.32691127 |
| 54 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.29595245 |
| 55 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.29157688 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.26168585 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.23487288 |
| 58 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.20716635 |
| 59 | GATA3_26560356_Chip-Seq_TH2_Human | 1.17861889 |
| 60 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.16684874 |
| 61 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.15055980 |
| 62 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.14822794 |
| 63 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.13083085 |
| 64 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.13083085 |
| 65 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10829773 |
| 66 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.10255597 |
| 67 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10192733 |
| 68 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.09557783 |
| 69 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.09468019 |
| 70 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09322213 |
| 71 | AR_20517297_ChIP-Seq_VCAP_Human | 1.08935957 |
| 72 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.08670769 |
| 73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.07419629 |
| 74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.07392650 |
| 75 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07064973 |
| 76 | P300_19829295_ChIP-Seq_ESCs_Human | 1.07055602 |
| 77 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05901723 |
| 78 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05858312 |
| 79 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05364231 |
| 80 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.05091125 |
| 81 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.04931172 |
| 82 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.02819537 |
| 83 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.00047696 |
| 84 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.99620205 |
| 85 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98775603 |
| 86 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.98751427 |
| 87 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.98417263 |
| 88 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.96390468 |
| 89 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.94452414 |
| 90 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.90987016 |
| 91 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.89913755 |
| 92 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.88897923 |
| 93 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.87769629 |
| 94 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.87087911 |
| 95 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.85524709 |
| 96 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.83632144 |
| 97 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83555938 |
| 98 | NCOR_22424771_ChIP-Seq_293T_Human | 0.82997886 |
| 99 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.82509427 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.82376033 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 3.66449313 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.45663007 |
| 3 | MP0008058_abnormal_DNA_repair | 2.67827170 |
| 4 | MP0002837_dystrophic_cardiac_calcinosis | 2.59940288 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.49408131 |
| 6 | MP0003786_premature_aging | 2.46814552 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.44897079 |
| 8 | MP0006072_abnormal_retinal_apoptosis | 2.41632818 |
| 9 | MP0003718_maternal_effect | 2.38326059 |
| 10 | MP0002138_abnormal_hepatobiliary_system | 2.32636580 |
| 11 | MP0005671_abnormal_response_to | 2.29686219 |
| 12 | MP0008872_abnormal_physiological_respon | 2.28948336 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.24964877 |
| 14 | MP0005084_abnormal_gallbladder_morpholo | 2.22575253 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.02864624 |
| 16 | MP0004957_abnormal_blastocyst_morpholog | 2.00992172 |
| 17 | MP0001853_heart_inflammation | 1.92779170 |
| 18 | MP0006035_abnormal_mitochondrial_morpho | 1.90895648 |
| 19 | MP0008875_abnormal_xenobiotic_pharmacok | 1.85350936 |
| 20 | MP0001968_abnormal_touch/_nociception | 1.76596718 |
| 21 | MP0002148_abnormal_hypersensitivity_rea | 1.74202779 |
| 22 | MP0002102_abnormal_ear_morphology | 1.72486124 |
| 23 | MP0005645_abnormal_hypothalamus_physiol | 1.72284359 |
| 24 | MP0003195_calcinosis | 1.69866694 |
| 25 | MP0000685_abnormal_immune_system | 1.68380787 |
| 26 | MP0002006_tumorigenesis | 1.62891947 |
| 27 | MP0009697_abnormal_copulation | 1.61121810 |
| 28 | MP0004145_abnormal_muscle_electrophysio | 1.60269012 |
| 29 | MP0009379_abnormal_foot_pigmentation | 1.59975021 |
| 30 | MP0002736_abnormal_nociception_after | 1.59012166 |
| 31 | MP0006292_abnormal_olfactory_placode | 1.50022024 |
| 32 | MP0008007_abnormal_cellular_replicative | 1.49080320 |
| 33 | MP0003646_muscle_fatigue | 1.47416798 |
| 34 | MP0002166_altered_tumor_susceptibility | 1.46225272 |
| 35 | MP0005646_abnormal_pituitary_gland | 1.45490960 |
| 36 | MP0003111_abnormal_nucleus_morphology | 1.38782166 |
| 37 | MP0002163_abnormal_gland_morphology | 1.35771381 |
| 38 | MP0009785_altered_susceptibility_to | 1.34278235 |
| 39 | MP0003077_abnormal_cell_cycle | 1.33561754 |
| 40 | MP0005551_abnormal_eye_electrophysiolog | 1.32250593 |
| 41 | MP0001800_abnormal_humoral_immune | 1.31690433 |
| 42 | MP0004147_increased_porphyrin_level | 1.31611741 |
| 43 | MP0003186_abnormal_redox_activity | 1.30271710 |
| 44 | MP0009333_abnormal_splenocyte_physiolog | 1.23103289 |
| 45 | MP0004142_abnormal_muscle_tone | 1.21975237 |
| 46 | MP0001873_stomach_inflammation | 1.21607694 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.17779165 |
| 48 | MP0001293_anophthalmia | 1.17656880 |
| 49 | MP0005379_endocrine/exocrine_gland_phen | 1.17184302 |
| 50 | MP0004885_abnormal_endolymph | 1.13565728 |
| 51 | MP0001790_abnormal_immune_system | 1.12799017 |
| 52 | MP0005387_immune_system_phenotype | 1.12799017 |
| 53 | MP0002876_abnormal_thyroid_physiology | 1.08975891 |
| 54 | MP0004215_abnormal_myocardial_fiber | 1.08437875 |
| 55 | MP0005000_abnormal_immune_tolerance | 1.07714430 |
| 56 | MP0005389_reproductive_system_phenotype | 1.05889409 |
| 57 | MP0005075_abnormal_melanosome_morpholog | 1.05376840 |
| 58 | MP0001485_abnormal_pinna_reflex | 1.05155108 |
| 59 | MP0005410_abnormal_fertilization | 1.04534036 |
| 60 | MP0005636_abnormal_mineral_homeostasis | 1.02584897 |
| 61 | MP0002254_reproductive_system_inflammat | 1.02584430 |
| 62 | MP0003866_abnormal_defecation | 0.99826701 |
| 63 | MP0005253_abnormal_eye_physiology | 0.99355036 |
| 64 | MP0000689_abnormal_spleen_morphology | 0.98958182 |
| 65 | MP0002693_abnormal_pancreas_physiology | 0.98238631 |
| 66 | MP0002160_abnormal_reproductive_system | 0.97520958 |
| 67 | MP0001905_abnormal_dopamine_level | 0.97293196 |
| 68 | MP0001529_abnormal_vocalization | 0.96832817 |
| 69 | MP0002723_abnormal_immune_serum | 0.96798085 |
| 70 | MP0003011_delayed_dark_adaptation | 0.96335845 |
| 71 | MP0009764_decreased_sensitivity_to | 0.94728518 |
| 72 | MP0002452_abnormal_antigen_presenting | 0.94014752 |
| 73 | MP0001919_abnormal_reproductive_system | 0.93687970 |
| 74 | MP0000383_abnormal_hair_follicle | 0.92562359 |
| 75 | MP0002420_abnormal_adaptive_immunity | 0.92341449 |
| 76 | MP0001819_abnormal_immune_cell | 0.91616637 |
| 77 | MP0000372_irregular_coat_pigmentation | 0.91069629 |
| 78 | MP0000427_abnormal_hair_cycle | 0.89980942 |
| 79 | MP0002398_abnormal_bone_marrow | 0.89527286 |
| 80 | MP0001929_abnormal_gametogenesis | 0.89230690 |
| 81 | MP0002277_abnormal_respiratory_mucosa | 0.88641899 |
| 82 | MP0001501_abnormal_sleep_pattern | 0.87716767 |
| 83 | MP0001986_abnormal_taste_sensitivity | 0.84698172 |
| 84 | MP0002210_abnormal_sex_determination | 0.81875388 |
| 85 | MP0005085_abnormal_gallbladder_physiolo | 0.80655073 |
| 86 | MP0001119_abnormal_female_reproductive | 0.79413068 |
| 87 | MP0008789_abnormal_olfactory_epithelium | 0.79255710 |
| 88 | MP0000716_abnormal_immune_system | 0.77608335 |
| 89 | MP0005167_abnormal_blood-brain_barrier | 0.77487101 |
| 90 | MP0005220_abnormal_exocrine_pancreas | 0.76714770 |
| 91 | MP0000653_abnormal_sex_gland | 0.76578717 |
| 92 | MP0002019_abnormal_tumor_incidence | 0.76181937 |
| 93 | MP0008995_early_reproductive_senescence | 0.74697395 |
| 94 | MP0001145_abnormal_male_reproductive | 0.74475951 |
| 95 | MP0002272_abnormal_nervous_system | 0.74337202 |
| 96 | MP0000703_abnormal_thymus_morphology | 0.74164033 |
| 97 | MP0005395_other_phenotype | 0.73846795 |
| 98 | MP0003252_abnormal_bile_duct | 0.72724870 |
| 99 | MP0002751_abnormal_autonomic_nervous | 0.72414897 |
| 100 | MP0002396_abnormal_hematopoietic_system | 0.71368695 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.35177070 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.02743639 |
| 3 | Acute encephalopathy (HP:0006846) | 3.93415139 |
| 4 | Increased CSF lactate (HP:0002490) | 3.92139575 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 3.87829127 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.81712772 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 3.71606497 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.70321281 |
| 9 | Methylmalonic acidemia (HP:0002912) | 3.64480737 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.51838106 |
| 11 | Aplastic anemia (HP:0001915) | 3.35403868 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.31113317 |
| 13 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.29811934 |
| 14 | Hepatic necrosis (HP:0002605) | 3.23578580 |
| 15 | Abnormality of alanine metabolism (HP:0010916) | 3.21500984 |
| 16 | Hyperalaninemia (HP:0003348) | 3.21500984 |
| 17 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.21500984 |
| 18 | Methylmalonic aciduria (HP:0012120) | 3.16457275 |
| 19 | Increased serum lactate (HP:0002151) | 3.08433125 |
| 20 | Colon cancer (HP:0003003) | 3.06348001 |
| 21 | Abnormality of B cell number (HP:0010975) | 2.98432423 |
| 22 | IgG deficiency (HP:0004315) | 2.93117790 |
| 23 | Congenital, generalized hypertrichosis (HP:0004540) | 2.84436790 |
| 24 | Cerebral edema (HP:0002181) | 2.83776890 |
| 25 | Stomatitis (HP:0010280) | 2.79203497 |
| 26 | Congenital stationary night blindness (HP:0007642) | 2.78857711 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.73600890 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.72615663 |
| 29 | Exertional dyspnea (HP:0002875) | 2.61103946 |
| 30 | Abolished electroretinogram (ERG) (HP:0000550) | 2.59129839 |
| 31 | Pancreatic cysts (HP:0001737) | 2.56552206 |
| 32 | Lactic acidosis (HP:0003128) | 2.51843514 |
| 33 | Optic disc pallor (HP:0000543) | 2.50027480 |
| 34 | Stomach cancer (HP:0012126) | 2.46469617 |
| 35 | Panhypogammaglobulinemia (HP:0003139) | 2.44163669 |
| 36 | Oral leukoplakia (HP:0002745) | 2.39190809 |
| 37 | Pancytopenia (HP:0001876) | 2.38025184 |
| 38 | Abnormality of midbrain morphology (HP:0002418) | 2.36436769 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.36436769 |
| 40 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.35838560 |
| 41 | Increased intramyocellular lipid droplets (HP:0012240) | 2.35661480 |
| 42 | Abnormality of T cell physiology (HP:0011840) | 2.35183895 |
| 43 | Nephronophthisis (HP:0000090) | 2.34913685 |
| 44 | Respiratory failure (HP:0002878) | 2.34328772 |
| 45 | Abnormality of serum amino acid levels (HP:0003112) | 2.32050251 |
| 46 | Abnormality of the renal cortex (HP:0011035) | 2.31129192 |
| 47 | Abnormality of vitamin B metabolism (HP:0004340) | 2.29655678 |
| 48 | Hypoproteinemia (HP:0003075) | 2.24411578 |
| 49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.24212596 |
| 50 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.23772686 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.21661621 |
| 52 | Lethargy (HP:0001254) | 2.18251728 |
| 53 | Supernumerary spleens (HP:0009799) | 2.18182621 |
| 54 | Abnormality of the renal medulla (HP:0100957) | 2.16325559 |
| 55 | Meckel diverticulum (HP:0002245) | 2.14838813 |
| 56 | Abnormality of the ileum (HP:0001549) | 2.14531154 |
| 57 | Poor head control (HP:0002421) | 2.13906328 |
| 58 | Abnormality of the pons (HP:0007361) | 2.13407540 |
| 59 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.13277505 |
| 60 | B lymphocytopenia (HP:0010976) | 2.12387365 |
| 61 | Leukodystrophy (HP:0002415) | 2.11751100 |
| 62 | Exercise intolerance (HP:0003546) | 2.10918623 |
| 63 | Abnormal number of erythroid precursors (HP:0012131) | 2.09602853 |
| 64 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.07538396 |
| 65 | Pancreatic fibrosis (HP:0100732) | 2.05988372 |
| 66 | Abnormality of T cells (HP:0002843) | 2.04080586 |
| 67 | Pendular nystagmus (HP:0012043) | 2.03234864 |
| 68 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.02512260 |
| 69 | Severe combined immunodeficiency (HP:0004430) | 2.02136955 |
| 70 | Abnormality of the labia minora (HP:0012880) | 2.02129001 |
| 71 | Bile duct proliferation (HP:0001408) | 2.01943078 |
| 72 | Abnormal biliary tract physiology (HP:0012439) | 2.01943078 |
| 73 | Clubbing of toes (HP:0100760) | 2.01326132 |
| 74 | Hyperglycinuria (HP:0003108) | 2.00907947 |
| 75 | IgM deficiency (HP:0002850) | 2.00429711 |
| 76 | Renal cortical cysts (HP:0000803) | 2.00268802 |
| 77 | Eosinophilia (HP:0001880) | 1.99790563 |
| 78 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.99441518 |
| 79 | Abnormality of the preputium (HP:0100587) | 1.98835131 |
| 80 | Increased muscle lipid content (HP:0009058) | 1.97485664 |
| 81 | True hermaphroditism (HP:0010459) | 1.97337059 |
| 82 | Cleft eyelid (HP:0000625) | 1.95633412 |
| 83 | Hyperglycinemia (HP:0002154) | 1.94852656 |
| 84 | Testicular atrophy (HP:0000029) | 1.94087717 |
| 85 | Dicarboxylic aciduria (HP:0003215) | 1.92485043 |
| 86 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.92485043 |
| 87 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.92450892 |
| 88 | Abnormality of urine glucose concentration (HP:0011016) | 1.92271645 |
| 89 | Glycosuria (HP:0003076) | 1.92271645 |
| 90 | Abnormality of methionine metabolism (HP:0010901) | 1.91994488 |
| 91 | Abnormality of glycine metabolism (HP:0010895) | 1.91577003 |
| 92 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.91577003 |
| 93 | Thyroiditis (HP:0100646) | 1.90648043 |
| 94 | Macrocytic anemia (HP:0001972) | 1.90105379 |
| 95 | Type 2 muscle fiber atrophy (HP:0003554) | 1.89322739 |
| 96 | Attenuation of retinal blood vessels (HP:0007843) | 1.89191774 |
| 97 | Hypoplasia of the pons (HP:0012110) | 1.88098429 |
| 98 | Constricted visual fields (HP:0001133) | 1.88033515 |
| 99 | Duplicated collecting system (HP:0000081) | 1.87610081 |
| 100 | Abnormality of the renal collecting system (HP:0004742) | 1.87595624 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.36525110 |
| 2 | EIF2AK3 | 3.30889160 |
| 3 | BUB1 | 3.29083704 |
| 4 | MST4 | 3.28975092 |
| 5 | NUAK1 | 3.01568062 |
| 6 | ZAK | 2.90539966 |
| 7 | TSSK6 | 2.53248915 |
| 8 | TLK1 | 2.53013650 |
| 9 | NEK1 | 2.23436454 |
| 10 | STK16 | 2.16365424 |
| 11 | EIF2AK1 | 2.15938711 |
| 12 | VRK1 | 2.15130107 |
| 13 | TAOK3 | 2.07995274 |
| 14 | PBK | 2.04288588 |
| 15 | MKNK2 | 1.95042483 |
| 16 | PLK3 | 1.92184674 |
| 17 | TXK | 1.80905604 |
| 18 | BMPR1B | 1.77939545 |
| 19 | MKNK1 | 1.76958812 |
| 20 | TRIM28 | 1.74983045 |
| 21 | ADRBK2 | 1.66841841 |
| 22 | OXSR1 | 1.66482112 |
| 23 | MAP4K2 | 1.64947672 |
| 24 | FRK | 1.64592231 |
| 25 | GRK1 | 1.61936736 |
| 26 | TEC | 1.55593419 |
| 27 | MAP2K6 | 1.47065565 |
| 28 | PASK | 1.43243522 |
| 29 | PLK4 | 1.42370047 |
| 30 | STK39 | 1.38268504 |
| 31 | NME1 | 1.38197423 |
| 32 | PLK2 | 1.37713940 |
| 33 | TAF1 | 1.36001892 |
| 34 | SRPK1 | 1.35294692 |
| 35 | PINK1 | 1.34483130 |
| 36 | WNK3 | 1.33368547 |
| 37 | WNK4 | 1.31617668 |
| 38 | EIF2AK2 | 1.28848330 |
| 39 | BCKDK | 1.15815153 |
| 40 | INSRR | 1.03755533 |
| 41 | CDK8 | 1.01282002 |
| 42 | ITK | 0.98183948 |
| 43 | CDC7 | 0.97487830 |
| 44 | TGFBR1 | 0.94618617 |
| 45 | KIT | 0.88570142 |
| 46 | RPS6KA5 | 0.86395587 |
| 47 | TTK | 0.84300344 |
| 48 | ALK | 0.81582712 |
| 49 | PLK1 | 0.78832462 |
| 50 | ERBB3 | 0.76946934 |
| 51 | ATR | 0.75262703 |
| 52 | DAPK1 | 0.72815323 |
| 53 | STK38L | 0.71097838 |
| 54 | BMPR2 | 0.69224849 |
| 55 | DYRK2 | 0.69185273 |
| 56 | PRKCE | 0.68239192 |
| 57 | MAP3K12 | 0.67561565 |
| 58 | WEE1 | 0.63234658 |
| 59 | PRKCQ | 0.61803533 |
| 60 | IKBKB | 0.61318815 |
| 61 | GRK5 | 0.60579607 |
| 62 | AURKB | 0.59937862 |
| 63 | CSNK1G3 | 0.59086942 |
| 64 | PRKCI | 0.58209757 |
| 65 | NLK | 0.57089186 |
| 66 | CSNK1G1 | 0.56818158 |
| 67 | NME2 | 0.56537204 |
| 68 | MAP4K1 | 0.55674565 |
| 69 | ACVR1B | 0.53386313 |
| 70 | PHKG1 | 0.53340869 |
| 71 | PHKG2 | 0.53340869 |
| 72 | MYLK | 0.53246161 |
| 73 | DAPK2 | 0.52603178 |
| 74 | TIE1 | 0.52577706 |
| 75 | PIK3CG | 0.52040489 |
| 76 | CSNK1A1L | 0.51207702 |
| 77 | CSNK1G2 | 0.49190642 |
| 78 | RPS6KA4 | 0.48661774 |
| 79 | KDR | 0.45911368 |
| 80 | SYK | 0.42384959 |
| 81 | CSNK2A1 | 0.41591537 |
| 82 | FLT3 | 0.41415037 |
| 83 | EPHA3 | 0.39329304 |
| 84 | ADRBK1 | 0.39293269 |
| 85 | PRKCG | 0.39147161 |
| 86 | IRAK1 | 0.38713217 |
| 87 | CDK19 | 0.38328662 |
| 88 | CHEK2 | 0.37316672 |
| 89 | MAPKAPK5 | 0.37079731 |
| 90 | STK4 | 0.36000671 |
| 91 | BTK | 0.35653667 |
| 92 | CSNK2A2 | 0.35609951 |
| 93 | LYN | 0.33481905 |
| 94 | LCK | 0.33294908 |
| 95 | BRSK2 | 0.33293619 |
| 96 | ILK | 0.31414171 |
| 97 | STK3 | 0.31039936 |
| 98 | DAPK3 | 0.30148542 |
| 99 | PDK2 | 0.28689047 |
| 100 | IGF1R | 0.26471411 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.72623901 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.99891592 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.97597669 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.76690577 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.67707115 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.66928118 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.65148823 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.54460957 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.28906610 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.20262326 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 2.17463609 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.16783465 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 2.11180511 |
| 14 | Allograft rejection_Homo sapiens_hsa05330 | 2.09994805 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.06423664 |
| 16 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.94139845 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.93139817 |
| 18 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.87930673 |
| 19 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.80793993 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.69766934 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.66558554 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.66393130 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.65402877 |
| 24 | RNA transport_Homo sapiens_hsa03013 | 1.63117250 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57556680 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56511287 |
| 27 | Alzheimers disease_Homo sapiens_hsa05010 | 1.56011460 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.54812004 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.54424470 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.53268885 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.46486943 |
| 32 | Base excision repair_Homo sapiens_hsa03410 | 1.45218510 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.34432795 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.34369997 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33947602 |
| 36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.33210868 |
| 37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32139365 |
| 38 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.16929288 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.14765344 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.12535785 |
| 41 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.09677343 |
| 42 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.07983637 |
| 43 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.95953450 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94268400 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.92408359 |
| 46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.91320304 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 0.87313712 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.85288246 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.83155339 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.82331470 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.77807061 |
| 52 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.77404220 |
| 53 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75881084 |
| 54 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.75780741 |
| 55 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.75428718 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.71952640 |
| 57 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.71883308 |
| 58 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.66470737 |
| 59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.65602633 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.62518762 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62063830 |
| 62 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.61707592 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60441527 |
| 64 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.59535947 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.59303931 |
| 66 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.58583042 |
| 67 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55984781 |
| 68 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.52654809 |
| 69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.52047363 |
| 70 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51847821 |
| 71 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.51660158 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.49877652 |
| 73 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.49457486 |
| 74 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48379678 |
| 75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.47420778 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46327794 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46076105 |
| 78 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.45993801 |
| 79 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.43479719 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42605689 |
| 81 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.42534906 |
| 82 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.42041443 |
| 83 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.41642778 |
| 84 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.41043987 |
| 85 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40803786 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.40637014 |
| 87 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.39870272 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.39806421 |
| 89 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.37588842 |
| 90 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37411530 |
| 91 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37013749 |
| 92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.35819751 |
| 93 | Cell cycle_Homo sapiens_hsa04110 | 0.34213978 |
| 94 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.34154374 |
| 95 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.31527207 |
| 96 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.29888791 |
| 97 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.28864486 |
| 98 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.26430502 |
| 99 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.26080649 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.25189006 |

