NPM1P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.20687812
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76206452
3rRNA modification (GO:0000154)4.70505927
4DNA deamination (GO:0045006)4.64474504
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34840963
6ATP synthesis coupled proton transport (GO:0015986)4.34840963
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.32971475
8regulation of cellular amino acid metabolic process (GO:0006521)4.14975948
9water-soluble vitamin biosynthetic process (GO:0042364)4.10683969
10cullin deneddylation (GO:0010388)4.09836617
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.98114382
12protein deneddylation (GO:0000338)3.96575585
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94138099
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.93074362
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92282518
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.91644869
17ribosome assembly (GO:0042255)3.89142095
18rRNA methylation (GO:0031167)3.88908865
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.87319037
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.85882388
21signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.85882388
22signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.85882388
23negative regulation of ligase activity (GO:0051352)3.84534811
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.84534811
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.83867965
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.83867965
27CENP-A containing nucleosome assembly (GO:0034080)3.74988218
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.67098476
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.67098476
30chromatin remodeling at centromere (GO:0031055)3.66484004
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63774062
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.62451417
33protein neddylation (GO:0045116)3.61023018
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60791265
35maturation of 5.8S rRNA (GO:0000460)3.55440122
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54205484
37regulation of mitotic spindle checkpoint (GO:1903504)3.54205484
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.47510266
39NADH dehydrogenase complex assembly (GO:0010257)3.47510266
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47510266
41ribosomal large subunit biogenesis (GO:0042273)3.46937038
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41991966
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41070640
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.37845117
45mitochondrial respiratory chain complex assembly (GO:0033108)3.33135573
46protein complex biogenesis (GO:0070271)3.32023789
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31262180
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31262180
49pseudouridine synthesis (GO:0001522)3.29713364
50chaperone-mediated protein transport (GO:0072321)3.27960680
51positive regulation of ligase activity (GO:0051351)3.27833641
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.24503377
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.22912916
54termination of RNA polymerase III transcription (GO:0006386)3.22912916
55deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.20637085
56DNA double-strand break processing (GO:0000729)3.20144465
57respiratory electron transport chain (GO:0022904)3.17107345
58DNA catabolic process, exonucleolytic (GO:0000738)3.16166329
59electron transport chain (GO:0022900)3.15235501
60IMP biosynthetic process (GO:0006188)3.12525083
61adenosine metabolic process (GO:0046085)3.11879152
62protein-cofactor linkage (GO:0018065)3.11004778
63organelle disassembly (GO:1903008)3.10358643
64platelet dense granule organization (GO:0060155)3.09046351
65aldehyde catabolic process (GO:0046185)3.02058291
66histone exchange (GO:0043486)2.99082128
67DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95895795
68purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.95287844
69kynurenine metabolic process (GO:0070189)2.94532982
70AMP metabolic process (GO:0046033)2.93658205
71regulation of cellular amine metabolic process (GO:0033238)2.93329325
72regulation of ubiquitin-protein transferase activity (GO:0051438)2.92057556
73rRNA processing (GO:0006364)2.90372427
74telomere maintenance via semi-conservative replication (GO:0032201)2.89347525
75purine nucleobase biosynthetic process (GO:0009113)2.88466394
76transcription from mitochondrial promoter (GO:0006390)2.87853539
77respiratory chain complex IV assembly (GO:0008535)2.84311448
78rRNA metabolic process (GO:0016072)2.83466701
79regulation of ligase activity (GO:0051340)2.83090253
80IMP metabolic process (GO:0046040)2.82553610
81positive regulation of cell cycle arrest (GO:0071158)2.82542925
82mitochondrial RNA metabolic process (GO:0000959)2.82524054
83nucleobase biosynthetic process (GO:0046112)2.81652546
84tRNA processing (GO:0008033)2.79558576
85oxidative phosphorylation (GO:0006119)2.79313819
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.75404024
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73713327
88isotype switching (GO:0045190)2.73713327
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73713327
90histone mRNA metabolic process (GO:0008334)2.68666913
91tRNA modification (GO:0006400)2.68381814
92tRNA metabolic process (GO:0006399)2.67127478
93viral mRNA export from host cell nucleus (GO:0046784)2.66385090
94protein targeting to mitochondrion (GO:0006626)2.65935015
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64294566
96peptidyl-histidine modification (GO:0018202)2.64282616
97RNA phosphodiester bond hydrolysis (GO:0090501)2.63266743
98DNA damage response, detection of DNA damage (GO:0042769)2.61396600
99spliceosomal snRNP assembly (GO:0000387)2.60474975
100establishment of integrated proviral latency (GO:0075713)2.59667295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.30059446
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.61700392
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.07800838
4E2F7_22180533_ChIP-Seq_HELA_Human3.89538906
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12096144
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04637549
7VDR_23849224_ChIP-Seq_CD4+_Human2.99093404
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83140894
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82388386
10VDR_22108803_ChIP-Seq_LS180_Human2.82254850
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.76989583
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76152286
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69900454
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.67555928
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64232738
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.62718770
17ELK1_19687146_ChIP-ChIP_HELA_Human2.61467646
18FOXP3_21729870_ChIP-Seq_TREG_Human2.50043795
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37572220
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32966416
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20315069
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17649929
23IGF1R_20145208_ChIP-Seq_DFB_Human2.01668913
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96413480
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94344783
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.93504763
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84180576
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83498241
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78296969
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75513793
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74542250
32EWS_26573619_Chip-Seq_HEK293_Human1.73498285
33ZNF274_21170338_ChIP-Seq_K562_Hela1.69200081
34MYC_18940864_ChIP-ChIP_HL60_Human1.66210203
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62993382
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61786296
37DCP1A_22483619_ChIP-Seq_HELA_Human1.54531269
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53598186
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51012247
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47677337
41TTF2_22483619_ChIP-Seq_HELA_Human1.45890841
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42735292
43GABP_19822575_ChIP-Seq_HepG2_Human1.40922274
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38859877
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.38600199
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38438080
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33272918
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32002508
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30322097
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27456794
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27031839
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26519036
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26173378
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.25411749
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.24393520
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23257046
57FUS_26573619_Chip-Seq_HEK293_Human1.20499120
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.20328838
59GATA3_26560356_Chip-Seq_TH2_Human1.19737676
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14702031
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.14702031
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14511575
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14011346
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13399988
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12090218
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12070954
67TAF15_26573619_Chip-Seq_HEK293_Human1.08174475
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.08054139
69TP53_22573176_ChIP-Seq_HFKS_Human1.07384757
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06279900
71AR_20517297_ChIP-Seq_VCAP_Human1.05852990
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.05459529
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05217097
74XRN2_22483619_ChIP-Seq_HELA_Human1.03698443
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03402324
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03100462
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02014238
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01211730
79P300_19829295_ChIP-Seq_ESCs_Human1.00137204
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98702874
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96805342
82MYB_26560356_Chip-Seq_TH2_Human0.96249387
83CBP_20019798_ChIP-Seq_JUKART_Human0.96193050
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96193050
85SPI1_23547873_ChIP-Seq_NB4_Human0.95556203
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93716969
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93504184
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92233710
89SOX2_19829295_ChIP-Seq_ESCs_Human0.91926029
90NANOG_19829295_ChIP-Seq_ESCs_Human0.91926029
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91767973
92THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90968647
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90477071
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.89805757
95ERG_20517297_ChIP-Seq_VCAP_Human0.89210318
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88648283
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88554640
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.88272030
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88178009
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88161514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.60826343
2MP0003806_abnormal_nucleotide_metabolis3.57849038
3MP0005671_abnormal_response_to3.37742488
4MP0010094_abnormal_chromosome_stability2.84137375
5MP0004147_increased_porphyrin_level2.75720488
6MP0006072_abnormal_retinal_apoptosis2.66028016
7MP0008058_abnormal_DNA_repair2.55427035
8MP0003718_maternal_effect2.36070679
9MP0002102_abnormal_ear_morphology2.34162988
10MP0006036_abnormal_mitochondrial_physio2.28955198
11MP0004957_abnormal_blastocyst_morpholog2.18575231
12MP0008007_abnormal_cellular_replicative2.07587249
13MP0002148_abnormal_hypersensitivity_rea2.06183538
14MP0005084_abnormal_gallbladder_morpholo2.06081692
15MP0008872_abnormal_physiological_respon2.04619090
16MP0000685_abnormal_immune_system1.99643115
17MP0008875_abnormal_xenobiotic_pharmacok1.95764947
18MP0003786_premature_aging1.92530151
19MP0001800_abnormal_humoral_immune1.88246112
20MP0003724_increased_susceptibility_to1.86267980
21MP0002837_dystrophic_cardiac_calcinosis1.83887670
22MP0004782_abnormal_surfactant_physiolog1.79929554
23MP0009785_altered_susceptibility_to1.78698214
24MP0006035_abnormal_mitochondrial_morpho1.78689285
25MP0003693_abnormal_embryo_hatching1.75958464
26MP0005000_abnormal_immune_tolerance1.75325635
27MP0009697_abnormal_copulation1.69988024
28MP0002166_altered_tumor_susceptibility1.69824024
29MP0002006_tumorigenesis1.67551246
30MP0008877_abnormal_DNA_methylation1.63117812
31MP0003195_calcinosis1.62950037
32MP0002452_abnormal_antigen_presenting1.50573525
33MP0005387_immune_system_phenotype1.47253191
34MP0001790_abnormal_immune_system1.47253191
35MP0002138_abnormal_hepatobiliary_system1.43983442
36MP0003763_abnormal_thymus_physiology1.43730132
37MP0003111_abnormal_nucleus_morphology1.40755290
38MP0002723_abnormal_immune_serum1.39794194
39MP0000372_irregular_coat_pigmentation1.35711626
40MP0009333_abnormal_splenocyte_physiolog1.33042047
41MP0002405_respiratory_system_inflammati1.32671644
42MP0005551_abnormal_eye_electrophysiolog1.29235183
43MP0001819_abnormal_immune_cell1.28077064
44MP0009764_decreased_sensitivity_to1.26868621
45MP0003436_decreased_susceptibility_to1.26284686
46MP0001873_stomach_inflammation1.25212040
47MP0002736_abnormal_nociception_after1.24761624
48MP0002420_abnormal_adaptive_immunity1.24702572
49MP0001764_abnormal_homeostasis1.24414267
50MP0000689_abnormal_spleen_morphology1.23011804
51MP0005646_abnormal_pituitary_gland1.22190268
52MP0005253_abnormal_eye_physiology1.20583302
53MP0005075_abnormal_melanosome_morpholog1.19439079
54MP0001881_abnormal_mammary_gland1.19091683
55MP0003186_abnormal_redox_activity1.16613637
56MP0001529_abnormal_vocalization1.14282756
57MP0003252_abnormal_bile_duct1.10933575
58MP0002398_abnormal_bone_marrow1.07136485
59MP0001986_abnormal_taste_sensitivity1.06298487
60MP0008775_abnormal_heart_ventricle1.03051718
61MP0003077_abnormal_cell_cycle1.02890815
62MP0002277_abnormal_respiratory_mucosa1.02602039
63MP0005389_reproductive_system_phenotype1.01745653
64MP0001293_anophthalmia0.99050894
65MP0000716_abnormal_immune_system0.98910733
66MP0004215_abnormal_myocardial_fiber0.96043987
67MP0002160_abnormal_reproductive_system0.95126355
68MP0000703_abnormal_thymus_morphology0.94922610
69MP0004885_abnormal_endolymph0.93675034
70MP0008789_abnormal_olfactory_epithelium0.92745329
71MP0002722_abnormal_immune_system0.92744470
72MP0004145_abnormal_muscle_electrophysio0.91868659
73MP0002019_abnormal_tumor_incidence0.91861681
74MP0002163_abnormal_gland_morphology0.90446159
75MP0008932_abnormal_embryonic_tissue0.90094735
76MP0002429_abnormal_blood_cell0.89278747
77MP0001845_abnormal_inflammatory_respons0.88438958
78MP0003866_abnormal_defecation0.87483003
79MP0006292_abnormal_olfactory_placode0.86546767
80MP0004084_abnormal_cardiac_muscle0.85540785
81MP0001905_abnormal_dopamine_level0.85275889
82MP0001968_abnormal_touch/_nociception0.83535199
83MP0010386_abnormal_urinary_bladder0.81890365
84MP0002419_abnormal_innate_immunity0.81771869
85MP0005410_abnormal_fertilization0.80223567
86MP0002876_abnormal_thyroid_physiology0.78907573
87MP0001984_abnormal_olfaction0.77214234
88MP0002234_abnormal_pharynx_morphology0.76944096
89MP0005025_abnormal_response_to0.76109698
90MP0010155_abnormal_intestine_physiology0.75966098
91MP0005319_abnormal_enzyme/_coenzyme0.75125357
92MP0008469_abnormal_protein_level0.75116286
93MP0001919_abnormal_reproductive_system0.74298486
94MP0000383_abnormal_hair_follicle0.73962473
95MP0001533_abnormal_skeleton_physiology0.73854626
96MP0001119_abnormal_female_reproductive0.72670633
97MP0002090_abnormal_vision0.72068753
98MP0000427_abnormal_hair_cycle0.71741480
99MP0008873_increased_physiological_sensi0.71350350
100MP0001501_abnormal_sleep_pattern0.71214373

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.40034577
2Mitochondrial inheritance (HP:0001427)4.11822974
3Increased CSF lactate (HP:0002490)4.08018196
4Acute encephalopathy (HP:0006846)3.99589157
5Abnormal mitochondria in muscle tissue (HP:0008316)3.84394261
6Increased hepatocellular lipid droplets (HP:0006565)3.83732657
7Progressive macrocephaly (HP:0004481)3.71471669
8Lipid accumulation in hepatocytes (HP:0006561)3.53618962
9Hepatocellular necrosis (HP:0001404)3.51377259
10Hepatic necrosis (HP:0002605)3.34738696
11Cerebral edema (HP:0002181)3.26365038
12Congenital, generalized hypertrichosis (HP:0004540)3.22520376
13Increased serum lactate (HP:0002151)3.17364941
14Abnormality of alanine metabolism (HP:0010916)3.17140395
15Hyperalaninemia (HP:0003348)3.17140395
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17140395
17Type 2 muscle fiber atrophy (HP:0003554)3.09555001
18Aplastic anemia (HP:0001915)3.07037268
19IgG deficiency (HP:0004315)3.06980182
20Methylmalonic acidemia (HP:0002912)3.04342761
21Abnormality of the prostate (HP:0008775)2.89480245
22Abnormality of aspartate family amino acid metabolism (HP:0010899)2.88652690
23Severe combined immunodeficiency (HP:0004430)2.87023278
24Abolished electroretinogram (ERG) (HP:0000550)2.74177659
25Lactic acidosis (HP:0003128)2.72097697
26Abnormality of methionine metabolism (HP:0010901)2.70795414
27Abnormality of serum amino acid levels (HP:0003112)2.64455918
28Renal Fanconi syndrome (HP:0001994)2.61241542
29Abnormality of B cell number (HP:0010975)2.55386094
30Pancytopenia (HP:0001876)2.54072293
31Panhypogammaglobulinemia (HP:0003139)2.52298045
32Methylmalonic aciduria (HP:0012120)2.51737854
33Type I transferrin isoform profile (HP:0003642)2.50471417
343-Methylglutaconic aciduria (HP:0003535)2.48919053
35Muscle fiber atrophy (HP:0100295)2.45355611
36Exertional dyspnea (HP:0002875)2.42904319
37B lymphocytopenia (HP:0010976)2.42368419
38Pancreatic cysts (HP:0001737)2.39588963
39Increased intramyocellular lipid droplets (HP:0012240)2.38492981
40Stomatitis (HP:0010280)2.38063596
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37878263
42Lethargy (HP:0001254)2.36957331
43Optic disc pallor (HP:0000543)2.35719932
44Combined immunodeficiency (HP:0005387)2.30642931
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26506061
46Attenuation of retinal blood vessels (HP:0007843)2.23372792
47Respiratory failure (HP:0002878)2.22515617
48Renal cortical cysts (HP:0000803)2.21134825
49Hyperglycinemia (HP:0002154)2.20673119
50Hypoproteinemia (HP:0003075)2.19251157
51Nephronophthisis (HP:0000090)2.15242664
52Leukodystrophy (HP:0002415)2.14026548
53Elevated erythrocyte sedimentation rate (HP:0003565)2.12965254
54Thyroiditis (HP:0100646)2.10509502
55Abnormality of the renal cortex (HP:0011035)2.10239403
56Hypothermia (HP:0002045)2.08752804
57Generalized aminoaciduria (HP:0002909)2.07931885
58Exercise intolerance (HP:0003546)2.05985595
59Pancreatic fibrosis (HP:0100732)2.05374619
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99555701
61Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99555701
62Abnormality of the pons (HP:0007361)1.98328080
63Abnormality of midbrain morphology (HP:0002418)1.96897133
64Molar tooth sign on MRI (HP:0002419)1.96897133
65Increased serum pyruvate (HP:0003542)1.96616752
66Palpitations (HP:0001962)1.95361737
67Constricted visual fields (HP:0001133)1.95324509
68Abnormality of glycine metabolism (HP:0010895)1.94819047
69Abnormality of serine family amino acid metabolism (HP:0010894)1.94819047
70Dyschromatopsia (HP:0007641)1.94574806
71True hermaphroditism (HP:0010459)1.93218880
72Testicular atrophy (HP:0000029)1.92548068
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91689137
74Dicarboxylic aciduria (HP:0003215)1.91689137
75Short tibia (HP:0005736)1.91671909
76Hypoplasia of the pons (HP:0012110)1.91308498
77Congenital stationary night blindness (HP:0007642)1.90831653
78Abnormality of the renal medulla (HP:0100957)1.90124969
79Increased muscle lipid content (HP:0009058)1.89613528
80Abnormality of the vitamin B12 metabolism (HP:0004341)1.88166872
81Reduced antithrombin III activity (HP:0001976)1.87268462
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86078931
83Abnormality of eosinophils (HP:0001879)1.85672759
84Decreased central vision (HP:0007663)1.82867287
85Abnormal protein glycosylation (HP:0012346)1.81836286
86Abnormal glycosylation (HP:0012345)1.81836286
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81836286
88Abnormal protein N-linked glycosylation (HP:0012347)1.81836286
89Abnormal spermatogenesis (HP:0008669)1.81035686
90Abnormality of the labia minora (HP:0012880)1.79636343
91Cerebral palsy (HP:0100021)1.78753215
92Hyperglycinuria (HP:0003108)1.78750444
93Respiratory difficulties (HP:0002880)1.77844957
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.76524788
95Abnormality of T cell physiology (HP:0011840)1.76134044
96Bile duct proliferation (HP:0001408)1.76022822
97Abnormal biliary tract physiology (HP:0012439)1.76022822
98Neoplasm of the colon (HP:0100273)1.74725401
99IgM deficiency (HP:0002850)1.73575921
100Glycosuria (HP:0003076)1.73487399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.97735542
2BUB13.71624830
3STK163.19045125
4TSSK63.05926862
5MST42.94422790
6TLK12.76536292
7MAP4K22.70928370
8ZAK2.51701217
9NUAK12.48818526
10EIF2AK12.42557612
11TAOK32.33943636
12VRK22.19931833
13MKNK12.15605226
14MAP3K122.07276791
15TXK1.94753291
16NEK11.75662436
17PLK31.65400991
18SRPK11.59017349
19TRIM281.58793701
20VRK11.57488951
21WNK31.54951664
22BMPR21.53096190
23BCR1.51180116
24MKNK21.46751225
25TEC1.46058461
26ADRBK21.45520866
27EIF2AK21.40355876
28MAP3K141.29113897
29OXSR11.28171331
30TESK21.28033271
31ACVR1B1.20696744
32PLK41.19733875
33BCKDK1.16418648
34CDC71.15086085
35MYLK1.14204742
36PBK1.14086107
37CDK81.11788881
38GRK11.11544451
39SIK31.10119794
40STK391.09097133
41KIT1.08157736
42FRK1.06855863
43ITK1.06824574
44NME11.03718775
45TIE11.02248607
46DAPK11.02032072
47PDK21.00448586
48IKBKB0.97088790
49BMPR1B0.95236586
50ERBB30.91459597
51WNK40.89450610
52ALK0.87721394
53KDR0.84780878
54PIK3CG0.83986267
55ILK0.78774540
56TNIK0.77710253
57RPS6KA50.74204055
58IKBKE0.69408972
59CDK190.68794734
60PLK10.65935010
61AURKB0.64696205
62CSF1R0.63879118
63PHKG20.63312834
64PHKG10.63312834
65MAP2K20.58833736
66GRK60.57922071
67BTK0.57400161
68FLT30.54584320
69SYK0.54316645
70PASK0.50535200
71ATR0.50176936
72WEE10.49430196
73CSNK1G30.49280633
74CSNK1A1L0.48079102
75OBSCN0.47559311
76SCYL20.46955690
77MAP4K10.46738234
78MAPKAPK50.46698495
79INSRR0.46414302
80CSNK2A10.46374096
81LYN0.46353442
82TTK0.45692115
83ADRBK10.45272071
84STK38L0.45160553
85TAF10.44995386
86PRKCQ0.44909620
87BRSK20.44280621
88CSNK2A20.43732472
89CSNK1G10.43169495
90PINK10.42707186
91FES0.42221195
92LCK0.41657131
93CSNK1G20.41447657
94RIPK40.40203590
95IGF1R0.37772619
96PLK20.36744692
97GRK70.36437028
98PAK40.36087864
99CCNB10.34540614
100MAPK130.34227769

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.99794114
2Asthma_Homo sapiens_hsa053103.23536460
3Protein export_Homo sapiens_hsa030602.99481185
4Oxidative phosphorylation_Homo sapiens_hsa001902.73010838
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60735254
6Allograft rejection_Homo sapiens_hsa053302.54485028
7Mismatch repair_Homo sapiens_hsa034302.50217446
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.49676653
9One carbon pool by folate_Homo sapiens_hsa006702.49036650
10Parkinsons disease_Homo sapiens_hsa050122.44596942
11Autoimmune thyroid disease_Homo sapiens_hsa053202.34728349
12RNA polymerase_Homo sapiens_hsa030202.32244053
13DNA replication_Homo sapiens_hsa030302.25713459
14Graft-versus-host disease_Homo sapiens_hsa053322.16679056
15Ribosome_Homo sapiens_hsa030102.12211363
16Type I diabetes mellitus_Homo sapiens_hsa049402.09986005
17Non-homologous end-joining_Homo sapiens_hsa034501.86907605
18RNA degradation_Homo sapiens_hsa030181.85083876
19Homologous recombination_Homo sapiens_hsa034401.70716924
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66323126
21Primary immunodeficiency_Homo sapiens_hsa053401.64138625
22RNA transport_Homo sapiens_hsa030131.62556333
23Nucleotide excision repair_Homo sapiens_hsa034201.62441048
24Spliceosome_Homo sapiens_hsa030401.59800578
25Antigen processing and presentation_Homo sapiens_hsa046121.57138100
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50183405
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49378740
28Basal transcription factors_Homo sapiens_hsa030221.49075068
29Propanoate metabolism_Homo sapiens_hsa006401.48683820
30Huntingtons disease_Homo sapiens_hsa050161.44382078
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42741990
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37006298
33Alzheimers disease_Homo sapiens_hsa050101.35613715
34Rheumatoid arthritis_Homo sapiens_hsa053231.30380371
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28570832
36Pyrimidine metabolism_Homo sapiens_hsa002401.21885904
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.15157892
38Purine metabolism_Homo sapiens_hsa002301.13636080
39Fanconi anemia pathway_Homo sapiens_hsa034601.13553781
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13418931
41Base excision repair_Homo sapiens_hsa034101.10649579
42Phototransduction_Homo sapiens_hsa047441.09257140
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07061197
44Caffeine metabolism_Homo sapiens_hsa002321.00270742
45Tryptophan metabolism_Homo sapiens_hsa003800.95038298
46Viral myocarditis_Homo sapiens_hsa054160.92176150
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89559713
48Nitrogen metabolism_Homo sapiens_hsa009100.86732166
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84703527
50Pyruvate metabolism_Homo sapiens_hsa006200.78494882
51Systemic lupus erythematosus_Homo sapiens_hsa053220.78235257
52Glutathione metabolism_Homo sapiens_hsa004800.77383097
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75760941
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69374754
55Hematopoietic cell lineage_Homo sapiens_hsa046400.68225282
56Sulfur metabolism_Homo sapiens_hsa009200.67841990
57Fatty acid elongation_Homo sapiens_hsa000620.67235792
58Peroxisome_Homo sapiens_hsa041460.66294754
59Cardiac muscle contraction_Homo sapiens_hsa042600.65278068
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64257070
61Regulation of autophagy_Homo sapiens_hsa041400.62520040
62Epstein-Barr virus infection_Homo sapiens_hsa051690.61168023
63Collecting duct acid secretion_Homo sapiens_hsa049660.59628760
64Linoleic acid metabolism_Homo sapiens_hsa005910.59023888
65Staphylococcus aureus infection_Homo sapiens_hsa051500.56450199
66Vitamin B6 metabolism_Homo sapiens_hsa007500.56333203
67Herpes simplex infection_Homo sapiens_hsa051680.55484939
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53536024
69Arachidonic acid metabolism_Homo sapiens_hsa005900.53198166
70Cell cycle_Homo sapiens_hsa041100.51529417
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51511475
72Leishmaniasis_Homo sapiens_hsa051400.51364985
73Selenocompound metabolism_Homo sapiens_hsa004500.51094942
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.49838748
75Chemical carcinogenesis_Homo sapiens_hsa052040.49485968
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48284144
77Metabolic pathways_Homo sapiens_hsa011000.48223049
78Legionellosis_Homo sapiens_hsa051340.42867908
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42390173
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40195708
81Folate biosynthesis_Homo sapiens_hsa007900.38025790
82Olfactory transduction_Homo sapiens_hsa047400.36875817
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36643728
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36513060
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35696653
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.34835577
87Butanoate metabolism_Homo sapiens_hsa006500.34224209
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34131813
89p53 signaling pathway_Homo sapiens_hsa041150.33882832
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31956961
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31623150
92Retinol metabolism_Homo sapiens_hsa008300.30946229
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30891170
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.30421160
95Carbon metabolism_Homo sapiens_hsa012000.28905682
96Sulfur relay system_Homo sapiens_hsa041220.27635084
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27540342
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21239138
99mRNA surveillance pathway_Homo sapiens_hsa030150.21196812
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19953740

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »