

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.20687812 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.76206452 |
| 3 | rRNA modification (GO:0000154) | 4.70505927 |
| 4 | DNA deamination (GO:0045006) | 4.64474504 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.34840963 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.34840963 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.32971475 |
| 8 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.14975948 |
| 9 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.10683969 |
| 10 | cullin deneddylation (GO:0010388) | 4.09836617 |
| 11 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.98114382 |
| 12 | protein deneddylation (GO:0000338) | 3.96575585 |
| 13 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.94138099 |
| 14 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.93074362 |
| 15 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.92282518 |
| 16 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.91644869 |
| 17 | ribosome assembly (GO:0042255) | 3.89142095 |
| 18 | rRNA methylation (GO:0031167) | 3.88908865 |
| 19 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.87319037 |
| 20 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.85882388 |
| 21 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.85882388 |
| 22 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.85882388 |
| 23 | negative regulation of ligase activity (GO:0051352) | 3.84534811 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.84534811 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.83867965 |
| 26 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.83867965 |
| 27 | CENP-A containing nucleosome assembly (GO:0034080) | 3.74988218 |
| 28 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.67098476 |
| 29 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.67098476 |
| 30 | chromatin remodeling at centromere (GO:0031055) | 3.66484004 |
| 31 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.63774062 |
| 32 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.62451417 |
| 33 | protein neddylation (GO:0045116) | 3.61023018 |
| 34 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.60791265 |
| 35 | maturation of 5.8S rRNA (GO:0000460) | 3.55440122 |
| 36 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.54205484 |
| 37 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.54205484 |
| 38 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.47510266 |
| 39 | NADH dehydrogenase complex assembly (GO:0010257) | 3.47510266 |
| 40 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.47510266 |
| 41 | ribosomal large subunit biogenesis (GO:0042273) | 3.46937038 |
| 42 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.41991966 |
| 43 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.41070640 |
| 44 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.37845117 |
| 45 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.33135573 |
| 46 | protein complex biogenesis (GO:0070271) | 3.32023789 |
| 47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.31262180 |
| 48 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.31262180 |
| 49 | pseudouridine synthesis (GO:0001522) | 3.29713364 |
| 50 | chaperone-mediated protein transport (GO:0072321) | 3.27960680 |
| 51 | positive regulation of ligase activity (GO:0051351) | 3.27833641 |
| 52 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.24503377 |
| 53 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.22912916 |
| 54 | termination of RNA polymerase III transcription (GO:0006386) | 3.22912916 |
| 55 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.20637085 |
| 56 | DNA double-strand break processing (GO:0000729) | 3.20144465 |
| 57 | respiratory electron transport chain (GO:0022904) | 3.17107345 |
| 58 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.16166329 |
| 59 | electron transport chain (GO:0022900) | 3.15235501 |
| 60 | IMP biosynthetic process (GO:0006188) | 3.12525083 |
| 61 | adenosine metabolic process (GO:0046085) | 3.11879152 |
| 62 | protein-cofactor linkage (GO:0018065) | 3.11004778 |
| 63 | organelle disassembly (GO:1903008) | 3.10358643 |
| 64 | platelet dense granule organization (GO:0060155) | 3.09046351 |
| 65 | aldehyde catabolic process (GO:0046185) | 3.02058291 |
| 66 | histone exchange (GO:0043486) | 2.99082128 |
| 67 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.95895795 |
| 68 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.95287844 |
| 69 | kynurenine metabolic process (GO:0070189) | 2.94532982 |
| 70 | AMP metabolic process (GO:0046033) | 2.93658205 |
| 71 | regulation of cellular amine metabolic process (GO:0033238) | 2.93329325 |
| 72 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.92057556 |
| 73 | rRNA processing (GO:0006364) | 2.90372427 |
| 74 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.89347525 |
| 75 | purine nucleobase biosynthetic process (GO:0009113) | 2.88466394 |
| 76 | transcription from mitochondrial promoter (GO:0006390) | 2.87853539 |
| 77 | respiratory chain complex IV assembly (GO:0008535) | 2.84311448 |
| 78 | rRNA metabolic process (GO:0016072) | 2.83466701 |
| 79 | regulation of ligase activity (GO:0051340) | 2.83090253 |
| 80 | IMP metabolic process (GO:0046040) | 2.82553610 |
| 81 | positive regulation of cell cycle arrest (GO:0071158) | 2.82542925 |
| 82 | mitochondrial RNA metabolic process (GO:0000959) | 2.82524054 |
| 83 | nucleobase biosynthetic process (GO:0046112) | 2.81652546 |
| 84 | tRNA processing (GO:0008033) | 2.79558576 |
| 85 | oxidative phosphorylation (GO:0006119) | 2.79313819 |
| 86 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.75404024 |
| 87 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.73713327 |
| 88 | isotype switching (GO:0045190) | 2.73713327 |
| 89 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.73713327 |
| 90 | histone mRNA metabolic process (GO:0008334) | 2.68666913 |
| 91 | tRNA modification (GO:0006400) | 2.68381814 |
| 92 | tRNA metabolic process (GO:0006399) | 2.67127478 |
| 93 | viral mRNA export from host cell nucleus (GO:0046784) | 2.66385090 |
| 94 | protein targeting to mitochondrion (GO:0006626) | 2.65935015 |
| 95 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.64294566 |
| 96 | peptidyl-histidine modification (GO:0018202) | 2.64282616 |
| 97 | RNA phosphodiester bond hydrolysis (GO:0090501) | 2.63266743 |
| 98 | DNA damage response, detection of DNA damage (GO:0042769) | 2.61396600 |
| 99 | spliceosomal snRNP assembly (GO:0000387) | 2.60474975 |
| 100 | establishment of integrated proviral latency (GO:0075713) | 2.59667295 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.30059446 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.61700392 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.07800838 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.89538906 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.12096144 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.04637549 |
| 7 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.99093404 |
| 8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.83140894 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.82388386 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.82254850 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.76989583 |
| 12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.76152286 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.69900454 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.67555928 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.64232738 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.62718770 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.61467646 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.50043795 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.37572220 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32966416 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.20315069 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.17649929 |
| 23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.01668913 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.96413480 |
| 25 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.94344783 |
| 26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.93504763 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.84180576 |
| 28 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.83498241 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.78296969 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.75513793 |
| 31 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.74542250 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.73498285 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.69200081 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.66210203 |
| 35 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.62993382 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61786296 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.54531269 |
| 38 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.53598186 |
| 39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.51012247 |
| 40 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.47677337 |
| 41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.45890841 |
| 42 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.42735292 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.40922274 |
| 44 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.38859877 |
| 45 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.38600199 |
| 46 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.38438080 |
| 47 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.33272918 |
| 48 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.32002508 |
| 49 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.30322097 |
| 50 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.27456794 |
| 51 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27031839 |
| 52 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26519036 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26173378 |
| 54 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.25411749 |
| 55 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.24393520 |
| 56 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.23257046 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.20499120 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20328838 |
| 59 | GATA3_26560356_Chip-Seq_TH2_Human | 1.19737676 |
| 60 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.14702031 |
| 61 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.14702031 |
| 62 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.14511575 |
| 63 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.14011346 |
| 64 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.13399988 |
| 65 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.12090218 |
| 66 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.12070954 |
| 67 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.08174475 |
| 68 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.08054139 |
| 69 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.07384757 |
| 70 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06279900 |
| 71 | AR_20517297_ChIP-Seq_VCAP_Human | 1.05852990 |
| 72 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.05459529 |
| 73 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05217097 |
| 74 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.03698443 |
| 75 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.03402324 |
| 76 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.03100462 |
| 77 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.02014238 |
| 78 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.01211730 |
| 79 | P300_19829295_ChIP-Seq_ESCs_Human | 1.00137204 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98702874 |
| 81 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.96805342 |
| 82 | MYB_26560356_Chip-Seq_TH2_Human | 0.96249387 |
| 83 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.96193050 |
| 84 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.96193050 |
| 85 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.95556203 |
| 86 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.93716969 |
| 87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.93504184 |
| 88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.92233710 |
| 89 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.91926029 |
| 90 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.91926029 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.91767973 |
| 92 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.90968647 |
| 93 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.90477071 |
| 94 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.89805757 |
| 95 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.89210318 |
| 96 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.88648283 |
| 97 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.88554640 |
| 98 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.88272030 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88178009 |
| 100 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88161514 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.60826343 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.57849038 |
| 3 | MP0005671_abnormal_response_to | 3.37742488 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.84137375 |
| 5 | MP0004147_increased_porphyrin_level | 2.75720488 |
| 6 | MP0006072_abnormal_retinal_apoptosis | 2.66028016 |
| 7 | MP0008058_abnormal_DNA_repair | 2.55427035 |
| 8 | MP0003718_maternal_effect | 2.36070679 |
| 9 | MP0002102_abnormal_ear_morphology | 2.34162988 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.28955198 |
| 11 | MP0004957_abnormal_blastocyst_morpholog | 2.18575231 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.07587249 |
| 13 | MP0002148_abnormal_hypersensitivity_rea | 2.06183538 |
| 14 | MP0005084_abnormal_gallbladder_morpholo | 2.06081692 |
| 15 | MP0008872_abnormal_physiological_respon | 2.04619090 |
| 16 | MP0000685_abnormal_immune_system | 1.99643115 |
| 17 | MP0008875_abnormal_xenobiotic_pharmacok | 1.95764947 |
| 18 | MP0003786_premature_aging | 1.92530151 |
| 19 | MP0001800_abnormal_humoral_immune | 1.88246112 |
| 20 | MP0003724_increased_susceptibility_to | 1.86267980 |
| 21 | MP0002837_dystrophic_cardiac_calcinosis | 1.83887670 |
| 22 | MP0004782_abnormal_surfactant_physiolog | 1.79929554 |
| 23 | MP0009785_altered_susceptibility_to | 1.78698214 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.78689285 |
| 25 | MP0003693_abnormal_embryo_hatching | 1.75958464 |
| 26 | MP0005000_abnormal_immune_tolerance | 1.75325635 |
| 27 | MP0009697_abnormal_copulation | 1.69988024 |
| 28 | MP0002166_altered_tumor_susceptibility | 1.69824024 |
| 29 | MP0002006_tumorigenesis | 1.67551246 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.63117812 |
| 31 | MP0003195_calcinosis | 1.62950037 |
| 32 | MP0002452_abnormal_antigen_presenting | 1.50573525 |
| 33 | MP0005387_immune_system_phenotype | 1.47253191 |
| 34 | MP0001790_abnormal_immune_system | 1.47253191 |
| 35 | MP0002138_abnormal_hepatobiliary_system | 1.43983442 |
| 36 | MP0003763_abnormal_thymus_physiology | 1.43730132 |
| 37 | MP0003111_abnormal_nucleus_morphology | 1.40755290 |
| 38 | MP0002723_abnormal_immune_serum | 1.39794194 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.35711626 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.33042047 |
| 41 | MP0002405_respiratory_system_inflammati | 1.32671644 |
| 42 | MP0005551_abnormal_eye_electrophysiolog | 1.29235183 |
| 43 | MP0001819_abnormal_immune_cell | 1.28077064 |
| 44 | MP0009764_decreased_sensitivity_to | 1.26868621 |
| 45 | MP0003436_decreased_susceptibility_to | 1.26284686 |
| 46 | MP0001873_stomach_inflammation | 1.25212040 |
| 47 | MP0002736_abnormal_nociception_after | 1.24761624 |
| 48 | MP0002420_abnormal_adaptive_immunity | 1.24702572 |
| 49 | MP0001764_abnormal_homeostasis | 1.24414267 |
| 50 | MP0000689_abnormal_spleen_morphology | 1.23011804 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.22190268 |
| 52 | MP0005253_abnormal_eye_physiology | 1.20583302 |
| 53 | MP0005075_abnormal_melanosome_morpholog | 1.19439079 |
| 54 | MP0001881_abnormal_mammary_gland | 1.19091683 |
| 55 | MP0003186_abnormal_redox_activity | 1.16613637 |
| 56 | MP0001529_abnormal_vocalization | 1.14282756 |
| 57 | MP0003252_abnormal_bile_duct | 1.10933575 |
| 58 | MP0002398_abnormal_bone_marrow | 1.07136485 |
| 59 | MP0001986_abnormal_taste_sensitivity | 1.06298487 |
| 60 | MP0008775_abnormal_heart_ventricle | 1.03051718 |
| 61 | MP0003077_abnormal_cell_cycle | 1.02890815 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 1.02602039 |
| 63 | MP0005389_reproductive_system_phenotype | 1.01745653 |
| 64 | MP0001293_anophthalmia | 0.99050894 |
| 65 | MP0000716_abnormal_immune_system | 0.98910733 |
| 66 | MP0004215_abnormal_myocardial_fiber | 0.96043987 |
| 67 | MP0002160_abnormal_reproductive_system | 0.95126355 |
| 68 | MP0000703_abnormal_thymus_morphology | 0.94922610 |
| 69 | MP0004885_abnormal_endolymph | 0.93675034 |
| 70 | MP0008789_abnormal_olfactory_epithelium | 0.92745329 |
| 71 | MP0002722_abnormal_immune_system | 0.92744470 |
| 72 | MP0004145_abnormal_muscle_electrophysio | 0.91868659 |
| 73 | MP0002019_abnormal_tumor_incidence | 0.91861681 |
| 74 | MP0002163_abnormal_gland_morphology | 0.90446159 |
| 75 | MP0008932_abnormal_embryonic_tissue | 0.90094735 |
| 76 | MP0002429_abnormal_blood_cell | 0.89278747 |
| 77 | MP0001845_abnormal_inflammatory_respons | 0.88438958 |
| 78 | MP0003866_abnormal_defecation | 0.87483003 |
| 79 | MP0006292_abnormal_olfactory_placode | 0.86546767 |
| 80 | MP0004084_abnormal_cardiac_muscle | 0.85540785 |
| 81 | MP0001905_abnormal_dopamine_level | 0.85275889 |
| 82 | MP0001968_abnormal_touch/_nociception | 0.83535199 |
| 83 | MP0010386_abnormal_urinary_bladder | 0.81890365 |
| 84 | MP0002419_abnormal_innate_immunity | 0.81771869 |
| 85 | MP0005410_abnormal_fertilization | 0.80223567 |
| 86 | MP0002876_abnormal_thyroid_physiology | 0.78907573 |
| 87 | MP0001984_abnormal_olfaction | 0.77214234 |
| 88 | MP0002234_abnormal_pharynx_morphology | 0.76944096 |
| 89 | MP0005025_abnormal_response_to | 0.76109698 |
| 90 | MP0010155_abnormal_intestine_physiology | 0.75966098 |
| 91 | MP0005319_abnormal_enzyme/_coenzyme | 0.75125357 |
| 92 | MP0008469_abnormal_protein_level | 0.75116286 |
| 93 | MP0001919_abnormal_reproductive_system | 0.74298486 |
| 94 | MP0000383_abnormal_hair_follicle | 0.73962473 |
| 95 | MP0001533_abnormal_skeleton_physiology | 0.73854626 |
| 96 | MP0001119_abnormal_female_reproductive | 0.72670633 |
| 97 | MP0002090_abnormal_vision | 0.72068753 |
| 98 | MP0000427_abnormal_hair_cycle | 0.71741480 |
| 99 | MP0008873_increased_physiological_sensi | 0.71350350 |
| 100 | MP0001501_abnormal_sleep_pattern | 0.71214373 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.40034577 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.11822974 |
| 3 | Increased CSF lactate (HP:0002490) | 4.08018196 |
| 4 | Acute encephalopathy (HP:0006846) | 3.99589157 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.84394261 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 3.83732657 |
| 7 | Progressive macrocephaly (HP:0004481) | 3.71471669 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 3.53618962 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.51377259 |
| 10 | Hepatic necrosis (HP:0002605) | 3.34738696 |
| 11 | Cerebral edema (HP:0002181) | 3.26365038 |
| 12 | Congenital, generalized hypertrichosis (HP:0004540) | 3.22520376 |
| 13 | Increased serum lactate (HP:0002151) | 3.17364941 |
| 14 | Abnormality of alanine metabolism (HP:0010916) | 3.17140395 |
| 15 | Hyperalaninemia (HP:0003348) | 3.17140395 |
| 16 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.17140395 |
| 17 | Type 2 muscle fiber atrophy (HP:0003554) | 3.09555001 |
| 18 | Aplastic anemia (HP:0001915) | 3.07037268 |
| 19 | IgG deficiency (HP:0004315) | 3.06980182 |
| 20 | Methylmalonic acidemia (HP:0002912) | 3.04342761 |
| 21 | Abnormality of the prostate (HP:0008775) | 2.89480245 |
| 22 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.88652690 |
| 23 | Severe combined immunodeficiency (HP:0004430) | 2.87023278 |
| 24 | Abolished electroretinogram (ERG) (HP:0000550) | 2.74177659 |
| 25 | Lactic acidosis (HP:0003128) | 2.72097697 |
| 26 | Abnormality of methionine metabolism (HP:0010901) | 2.70795414 |
| 27 | Abnormality of serum amino acid levels (HP:0003112) | 2.64455918 |
| 28 | Renal Fanconi syndrome (HP:0001994) | 2.61241542 |
| 29 | Abnormality of B cell number (HP:0010975) | 2.55386094 |
| 30 | Pancytopenia (HP:0001876) | 2.54072293 |
| 31 | Panhypogammaglobulinemia (HP:0003139) | 2.52298045 |
| 32 | Methylmalonic aciduria (HP:0012120) | 2.51737854 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.50471417 |
| 34 | 3-Methylglutaconic aciduria (HP:0003535) | 2.48919053 |
| 35 | Muscle fiber atrophy (HP:0100295) | 2.45355611 |
| 36 | Exertional dyspnea (HP:0002875) | 2.42904319 |
| 37 | B lymphocytopenia (HP:0010976) | 2.42368419 |
| 38 | Pancreatic cysts (HP:0001737) | 2.39588963 |
| 39 | Increased intramyocellular lipid droplets (HP:0012240) | 2.38492981 |
| 40 | Stomatitis (HP:0010280) | 2.38063596 |
| 41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.37878263 |
| 42 | Lethargy (HP:0001254) | 2.36957331 |
| 43 | Optic disc pallor (HP:0000543) | 2.35719932 |
| 44 | Combined immunodeficiency (HP:0005387) | 2.30642931 |
| 45 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.26506061 |
| 46 | Attenuation of retinal blood vessels (HP:0007843) | 2.23372792 |
| 47 | Respiratory failure (HP:0002878) | 2.22515617 |
| 48 | Renal cortical cysts (HP:0000803) | 2.21134825 |
| 49 | Hyperglycinemia (HP:0002154) | 2.20673119 |
| 50 | Hypoproteinemia (HP:0003075) | 2.19251157 |
| 51 | Nephronophthisis (HP:0000090) | 2.15242664 |
| 52 | Leukodystrophy (HP:0002415) | 2.14026548 |
| 53 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.12965254 |
| 54 | Thyroiditis (HP:0100646) | 2.10509502 |
| 55 | Abnormality of the renal cortex (HP:0011035) | 2.10239403 |
| 56 | Hypothermia (HP:0002045) | 2.08752804 |
| 57 | Generalized aminoaciduria (HP:0002909) | 2.07931885 |
| 58 | Exercise intolerance (HP:0003546) | 2.05985595 |
| 59 | Pancreatic fibrosis (HP:0100732) | 2.05374619 |
| 60 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.99555701 |
| 61 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.99555701 |
| 62 | Abnormality of the pons (HP:0007361) | 1.98328080 |
| 63 | Abnormality of midbrain morphology (HP:0002418) | 1.96897133 |
| 64 | Molar tooth sign on MRI (HP:0002419) | 1.96897133 |
| 65 | Increased serum pyruvate (HP:0003542) | 1.96616752 |
| 66 | Palpitations (HP:0001962) | 1.95361737 |
| 67 | Constricted visual fields (HP:0001133) | 1.95324509 |
| 68 | Abnormality of glycine metabolism (HP:0010895) | 1.94819047 |
| 69 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.94819047 |
| 70 | Dyschromatopsia (HP:0007641) | 1.94574806 |
| 71 | True hermaphroditism (HP:0010459) | 1.93218880 |
| 72 | Testicular atrophy (HP:0000029) | 1.92548068 |
| 73 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.91689137 |
| 74 | Dicarboxylic aciduria (HP:0003215) | 1.91689137 |
| 75 | Short tibia (HP:0005736) | 1.91671909 |
| 76 | Hypoplasia of the pons (HP:0012110) | 1.91308498 |
| 77 | Congenital stationary night blindness (HP:0007642) | 1.90831653 |
| 78 | Abnormality of the renal medulla (HP:0100957) | 1.90124969 |
| 79 | Increased muscle lipid content (HP:0009058) | 1.89613528 |
| 80 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.88166872 |
| 81 | Reduced antithrombin III activity (HP:0001976) | 1.87268462 |
| 82 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.86078931 |
| 83 | Abnormality of eosinophils (HP:0001879) | 1.85672759 |
| 84 | Decreased central vision (HP:0007663) | 1.82867287 |
| 85 | Abnormal protein glycosylation (HP:0012346) | 1.81836286 |
| 86 | Abnormal glycosylation (HP:0012345) | 1.81836286 |
| 87 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.81836286 |
| 88 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.81836286 |
| 89 | Abnormal spermatogenesis (HP:0008669) | 1.81035686 |
| 90 | Abnormality of the labia minora (HP:0012880) | 1.79636343 |
| 91 | Cerebral palsy (HP:0100021) | 1.78753215 |
| 92 | Hyperglycinuria (HP:0003108) | 1.78750444 |
| 93 | Respiratory difficulties (HP:0002880) | 1.77844957 |
| 94 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.76524788 |
| 95 | Abnormality of T cell physiology (HP:0011840) | 1.76134044 |
| 96 | Bile duct proliferation (HP:0001408) | 1.76022822 |
| 97 | Abnormal biliary tract physiology (HP:0012439) | 1.76022822 |
| 98 | Neoplasm of the colon (HP:0100273) | 1.74725401 |
| 99 | IgM deficiency (HP:0002850) | 1.73575921 |
| 100 | Glycosuria (HP:0003076) | 1.73487399 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK3 | 3.97735542 |
| 2 | BUB1 | 3.71624830 |
| 3 | STK16 | 3.19045125 |
| 4 | TSSK6 | 3.05926862 |
| 5 | MST4 | 2.94422790 |
| 6 | TLK1 | 2.76536292 |
| 7 | MAP4K2 | 2.70928370 |
| 8 | ZAK | 2.51701217 |
| 9 | NUAK1 | 2.48818526 |
| 10 | EIF2AK1 | 2.42557612 |
| 11 | TAOK3 | 2.33943636 |
| 12 | VRK2 | 2.19931833 |
| 13 | MKNK1 | 2.15605226 |
| 14 | MAP3K12 | 2.07276791 |
| 15 | TXK | 1.94753291 |
| 16 | NEK1 | 1.75662436 |
| 17 | PLK3 | 1.65400991 |
| 18 | SRPK1 | 1.59017349 |
| 19 | TRIM28 | 1.58793701 |
| 20 | VRK1 | 1.57488951 |
| 21 | WNK3 | 1.54951664 |
| 22 | BMPR2 | 1.53096190 |
| 23 | BCR | 1.51180116 |
| 24 | MKNK2 | 1.46751225 |
| 25 | TEC | 1.46058461 |
| 26 | ADRBK2 | 1.45520866 |
| 27 | EIF2AK2 | 1.40355876 |
| 28 | MAP3K14 | 1.29113897 |
| 29 | OXSR1 | 1.28171331 |
| 30 | TESK2 | 1.28033271 |
| 31 | ACVR1B | 1.20696744 |
| 32 | PLK4 | 1.19733875 |
| 33 | BCKDK | 1.16418648 |
| 34 | CDC7 | 1.15086085 |
| 35 | MYLK | 1.14204742 |
| 36 | PBK | 1.14086107 |
| 37 | CDK8 | 1.11788881 |
| 38 | GRK1 | 1.11544451 |
| 39 | SIK3 | 1.10119794 |
| 40 | STK39 | 1.09097133 |
| 41 | KIT | 1.08157736 |
| 42 | FRK | 1.06855863 |
| 43 | ITK | 1.06824574 |
| 44 | NME1 | 1.03718775 |
| 45 | TIE1 | 1.02248607 |
| 46 | DAPK1 | 1.02032072 |
| 47 | PDK2 | 1.00448586 |
| 48 | IKBKB | 0.97088790 |
| 49 | BMPR1B | 0.95236586 |
| 50 | ERBB3 | 0.91459597 |
| 51 | WNK4 | 0.89450610 |
| 52 | ALK | 0.87721394 |
| 53 | KDR | 0.84780878 |
| 54 | PIK3CG | 0.83986267 |
| 55 | ILK | 0.78774540 |
| 56 | TNIK | 0.77710253 |
| 57 | RPS6KA5 | 0.74204055 |
| 58 | IKBKE | 0.69408972 |
| 59 | CDK19 | 0.68794734 |
| 60 | PLK1 | 0.65935010 |
| 61 | AURKB | 0.64696205 |
| 62 | CSF1R | 0.63879118 |
| 63 | PHKG2 | 0.63312834 |
| 64 | PHKG1 | 0.63312834 |
| 65 | MAP2K2 | 0.58833736 |
| 66 | GRK6 | 0.57922071 |
| 67 | BTK | 0.57400161 |
| 68 | FLT3 | 0.54584320 |
| 69 | SYK | 0.54316645 |
| 70 | PASK | 0.50535200 |
| 71 | ATR | 0.50176936 |
| 72 | WEE1 | 0.49430196 |
| 73 | CSNK1G3 | 0.49280633 |
| 74 | CSNK1A1L | 0.48079102 |
| 75 | OBSCN | 0.47559311 |
| 76 | SCYL2 | 0.46955690 |
| 77 | MAP4K1 | 0.46738234 |
| 78 | MAPKAPK5 | 0.46698495 |
| 79 | INSRR | 0.46414302 |
| 80 | CSNK2A1 | 0.46374096 |
| 81 | LYN | 0.46353442 |
| 82 | TTK | 0.45692115 |
| 83 | ADRBK1 | 0.45272071 |
| 84 | STK38L | 0.45160553 |
| 85 | TAF1 | 0.44995386 |
| 86 | PRKCQ | 0.44909620 |
| 87 | BRSK2 | 0.44280621 |
| 88 | CSNK2A2 | 0.43732472 |
| 89 | CSNK1G1 | 0.43169495 |
| 90 | PINK1 | 0.42707186 |
| 91 | FES | 0.42221195 |
| 92 | LCK | 0.41657131 |
| 93 | CSNK1G2 | 0.41447657 |
| 94 | RIPK4 | 0.40203590 |
| 95 | IGF1R | 0.37772619 |
| 96 | PLK2 | 0.36744692 |
| 97 | GRK7 | 0.36437028 |
| 98 | PAK4 | 0.36087864 |
| 99 | CCNB1 | 0.34540614 |
| 100 | MAPK13 | 0.34227769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.99794114 |
| 2 | Asthma_Homo sapiens_hsa05310 | 3.23536460 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.99481185 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.73010838 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.60735254 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.54485028 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.50217446 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.49676653 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.49036650 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.44596942 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.34728349 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.32244053 |
| 13 | DNA replication_Homo sapiens_hsa03030 | 2.25713459 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.16679056 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 2.12211363 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.09986005 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86907605 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.85083876 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.70716924 |
| 20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.66323126 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.64138625 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.62556333 |
| 23 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.62441048 |
| 24 | Spliceosome_Homo sapiens_hsa03040 | 1.59800578 |
| 25 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.57138100 |
| 26 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.50183405 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.49378740 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.49075068 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.48683820 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.44382078 |
| 31 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.42741990 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.37006298 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.35613715 |
| 34 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.30380371 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28570832 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.21885904 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.15157892 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.13636080 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.13553781 |
| 40 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.13418931 |
| 41 | Base excision repair_Homo sapiens_hsa03410 | 1.10649579 |
| 42 | Phototransduction_Homo sapiens_hsa04744 | 1.09257140 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.07061197 |
| 44 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.00270742 |
| 45 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.95038298 |
| 46 | Viral myocarditis_Homo sapiens_hsa05416 | 0.92176150 |
| 47 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.89559713 |
| 48 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.86732166 |
| 49 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.84703527 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78494882 |
| 51 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.78235257 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77383097 |
| 53 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.75760941 |
| 54 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.69374754 |
| 55 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.68225282 |
| 56 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.67841990 |
| 57 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.67235792 |
| 58 | Peroxisome_Homo sapiens_hsa04146 | 0.66294754 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.65278068 |
| 60 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.64257070 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.62520040 |
| 62 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.61168023 |
| 63 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.59628760 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.59023888 |
| 65 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.56450199 |
| 66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56333203 |
| 67 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.55484939 |
| 68 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.53536024 |
| 69 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.53198166 |
| 70 | Cell cycle_Homo sapiens_hsa04110 | 0.51529417 |
| 71 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.51511475 |
| 72 | Leishmaniasis_Homo sapiens_hsa05140 | 0.51364985 |
| 73 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51094942 |
| 74 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.49838748 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49485968 |
| 76 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48284144 |
| 77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48223049 |
| 78 | Legionellosis_Homo sapiens_hsa05134 | 0.42867908 |
| 79 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.42390173 |
| 80 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40195708 |
| 81 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38025790 |
| 82 | Olfactory transduction_Homo sapiens_hsa04740 | 0.36875817 |
| 83 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36643728 |
| 84 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36513060 |
| 85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35696653 |
| 86 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.34835577 |
| 87 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.34224209 |
| 88 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.34131813 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.33882832 |
| 90 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.31956961 |
| 91 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.31623150 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30946229 |
| 93 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30891170 |
| 94 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.30421160 |
| 95 | Carbon metabolism_Homo sapiens_hsa01200 | 0.28905682 |
| 96 | Sulfur relay system_Homo sapiens_hsa04122 | 0.27635084 |
| 97 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27540342 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21239138 |
| 99 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.21196812 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19953740 |

