NPM1P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.64228435
2proteasome assembly (GO:0043248)5.28644949
3rRNA modification (GO:0000154)5.08759430
4rRNA methylation (GO:0031167)4.95578467
5regulation of isotype switching to IgG isotypes (GO:0048302)4.91031221
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.83376088
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.64409331
8chaperone-mediated protein transport (GO:0072321)4.15621562
9regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.10364466
10regulation of immunoglobulin secretion (GO:0051023)4.09787850
11cullin deneddylation (GO:0010388)4.06224029
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.05665091
13protein deneddylation (GO:0000338)3.98132070
14water-soluble vitamin biosynthetic process (GO:0042364)3.85847824
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80279583
16positive regulation of isotype switching (GO:0045830)3.71600555
17ribosome assembly (GO:0042255)3.70857561
18respiratory chain complex IV assembly (GO:0008535)3.68876817
19mitochondrial respiratory chain complex assembly (GO:0033108)3.68115225
20ATP synthesis coupled proton transport (GO:0015986)3.68084099
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68084099
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67054650
23mitochondrial RNA metabolic process (GO:0000959)3.66430572
24positive regulation of DNA recombination (GO:0045911)3.65643746
25regulation of chronic inflammatory response (GO:0002676)3.63577818
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63383981
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61968487
28regulation of cellular amino acid metabolic process (GO:0006521)3.61115432
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.60461657
30termination of RNA polymerase III transcription (GO:0006386)3.60461657
31protein complex biogenesis (GO:0070271)3.57935101
32transcription from mitochondrial promoter (GO:0006390)3.56671591
33maturation of 5.8S rRNA (GO:0000460)3.55112836
34cytidine deamination (GO:0009972)3.54954769
35cytidine metabolic process (GO:0046087)3.54954769
36cytidine catabolic process (GO:0006216)3.54954769
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50115376
38protein neddylation (GO:0045116)3.48630109
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48105441
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48015307
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48015307
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48015307
43pseudouridine synthesis (GO:0001522)3.44999601
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41342381
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41342381
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40376807
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37584803
48negative regulation of ligase activity (GO:0051352)3.37584803
49termination of RNA polymerase I transcription (GO:0006363)3.37155836
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.35221767
51NADH dehydrogenase complex assembly (GO:0010257)3.35221767
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35221767
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.31261413
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31261413
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.28029514
56GTP biosynthetic process (GO:0006183)3.17755496
57cytochrome complex assembly (GO:0017004)3.14930897
58somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.13102670
59isotype switching (GO:0045190)3.13102670
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.13102670
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12866737
62chromatin remodeling at centromere (GO:0031055)3.12470809
63transcription elongation from RNA polymerase I promoter (GO:0006362)3.10958789
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09905171
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09905171
66rRNA processing (GO:0006364)3.07692247
67regulation of podosome assembly (GO:0071801)3.04899118
68protein targeting to mitochondrion (GO:0006626)3.02614869
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02186708
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00429803
71rRNA metabolic process (GO:0016072)3.00251553
72CENP-A containing nucleosome assembly (GO:0034080)2.98587499
73DNA double-strand break processing (GO:0000729)2.98295840
74replication fork processing (GO:0031297)2.97257013
75histone mRNA metabolic process (GO:0008334)2.97119573
76positive regulation of immunoglobulin production (GO:0002639)2.93536528
77positive regulation of interleukin-17 production (GO:0032740)2.89920872
78DNA catabolic process, exonucleolytic (GO:0000738)2.88559303
79positive regulation of ligase activity (GO:0051351)2.87879367
80pyrimidine ribonucleoside catabolic process (GO:0046133)2.85986601
81establishment of protein localization to mitochondrion (GO:0072655)2.83033687
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81766578
83ribosome biogenesis (GO:0042254)2.81225242
84viral mRNA export from host cell nucleus (GO:0046784)2.80618067
85tRNA processing (GO:0008033)2.80504339
86IMP biosynthetic process (GO:0006188)2.78399753
87tRNA metabolic process (GO:0006399)2.77876483
88protein localization to mitochondrion (GO:0070585)2.77260669
89UTP biosynthetic process (GO:0006228)2.74603111
90amino acid activation (GO:0043038)2.73915086
91tRNA aminoacylation (GO:0043039)2.73915086
92DNA replication-dependent nucleosome assembly (GO:0006335)2.73517563
93DNA replication-dependent nucleosome organization (GO:0034723)2.73517563
94spliceosomal snRNP assembly (GO:0000387)2.72442792
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72401435
96recombinational repair (GO:0000725)2.70548561
97ncRNA metabolic process (GO:0034660)2.69906360
98positive regulation of cell cycle arrest (GO:0071158)2.69695787
99folic acid-containing compound biosynthetic process (GO:0009396)2.69618300
100double-strand break repair via homologous recombination (GO:0000724)2.69168110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92346865
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.49737298
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.96969524
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47276656
5E2F7_22180533_ChIP-Seq_HELA_Human3.15778446
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01228967
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96887278
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.79537844
9VDR_23849224_ChIP-Seq_CD4+_Human2.74497795
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73546221
11ELK1_19687146_ChIP-ChIP_HELA_Human2.72414906
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58850928
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.57555217
14VDR_22108803_ChIP-Seq_LS180_Human2.51611156
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38968855
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.37711174
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35614969
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32977854
19FOXP3_21729870_ChIP-Seq_TREG_Human2.28769645
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26942674
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.25839138
22ZNF274_21170338_ChIP-Seq_K562_Hela2.09672222
23EWS_26573619_Chip-Seq_HEK293_Human2.04889370
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02666299
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96099053
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93454867
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84129695
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.81440833
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81279235
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78440213
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74313724
32MYC_18940864_ChIP-ChIP_HL60_Human1.72290738
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71443607
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70307112
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66546353
36IGF1R_20145208_ChIP-Seq_DFB_Human1.65202466
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57685335
38DCP1A_22483619_ChIP-Seq_HELA_Human1.56191255
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53449883
40FUS_26573619_Chip-Seq_HEK293_Human1.45809254
41GABP_19822575_ChIP-Seq_HepG2_Human1.44734651
42TTF2_22483619_ChIP-Seq_HELA_Human1.41565197
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41386291
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41005193
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.37251389
46TAF15_26573619_Chip-Seq_HEK293_Human1.36468176
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35393518
48TP53_22573176_ChIP-Seq_HFKS_Human1.31579084
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30218721
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30108944
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28217270
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27607647
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21870050
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21412801
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20692702
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17104214
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.17051779
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16513374
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15866375
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.15866375
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15366176
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15134167
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.13684782
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13394689
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11648237
66P300_19829295_ChIP-Seq_ESCs_Human1.11385875
67NANOG_19829295_ChIP-Seq_ESCs_Human1.11325095
68SOX2_19829295_ChIP-Seq_ESCs_Human1.11325095
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10668787
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09454145
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.08724189
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06913087
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06655899
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06058315
75GATA3_26560356_Chip-Seq_TH2_Human1.03145524
76CBP_20019798_ChIP-Seq_JUKART_Human1.02634080
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02634080
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02408575
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02209492
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02066968
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.02050641
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02036329
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01713905
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01265058
85XRN2_22483619_ChIP-Seq_HELA_Human1.00539319
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00393024
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96137406
88ER_23166858_ChIP-Seq_MCF-7_Human0.95716282
89AR_20517297_ChIP-Seq_VCAP_Human0.94894811
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93791945
91NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92556502
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.92477401
93BCAT_22108803_ChIP-Seq_LS180_Human0.87589868
94HOXB7_26014856_ChIP-Seq_BT474_Human0.87056142
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86952699
96RBPJ_21746931_ChIP-Seq_IB4_Human0.86672991
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86512168
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86181655
99NCOR_22424771_ChIP-Seq_293T_Human0.84584563
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.84415264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation2.97495889
2MP0001835_abnormal_antigen_presentation2.90837275
3MP0008875_abnormal_xenobiotic_pharmacok2.84795685
4MP0003195_calcinosis2.84537013
5MP0003786_premature_aging2.74219713
6MP0008877_abnormal_DNA_methylation2.71325306
7MP0008057_abnormal_DNA_replication2.65937304
8MP0004957_abnormal_blastocyst_morpholog2.59328609
9MP0002102_abnormal_ear_morphology2.54759120
10MP0008058_abnormal_DNA_repair2.49828261
11MP0005671_abnormal_response_to2.42600260
12MP0003646_muscle_fatigue2.40225283
13MP0008872_abnormal_physiological_respon2.35856008
14MP0003693_abnormal_embryo_hatching2.30098643
15MP0010094_abnormal_chromosome_stability2.29040230
16MP0001348_abnormal_lacrimal_gland2.18302233
17MP0005377_hearing/vestibular/ear_phenot2.15333113
18MP0003878_abnormal_ear_physiology2.15333113
19MP0006072_abnormal_retinal_apoptosis2.00702627
20MP0009333_abnormal_splenocyte_physiolog1.89300204
21MP0006292_abnormal_olfactory_placode1.82505815
22MP0005084_abnormal_gallbladder_morpholo1.81889840
23MP0002837_dystrophic_cardiac_calcinosis1.76496027
24MP0003806_abnormal_nucleotide_metabolis1.73961183
25MP0003718_maternal_effect1.68948636
26MP0003890_abnormal_embryonic-extraembry1.63114811
27MP0006035_abnormal_mitochondrial_morpho1.63053596
28MP0002138_abnormal_hepatobiliary_system1.59372634
29MP0005551_abnormal_eye_electrophysiolog1.54883971
30MP0004145_abnormal_muscle_electrophysio1.48384648
31MP0003011_delayed_dark_adaptation1.47629497
32MP0001485_abnormal_pinna_reflex1.46716871
33MP0002160_abnormal_reproductive_system1.46285991
34MP0006082_CNS_inflammation1.43876393
35MP0006036_abnormal_mitochondrial_physio1.40207194
36MP0003567_abnormal_fetal_cardiomyocyte1.37236915
37MP0002736_abnormal_nociception_after1.34143481
38MP0005387_immune_system_phenotype1.32858924
39MP0001790_abnormal_immune_system1.32858924
40MP0001853_heart_inflammation1.31154064
41MP0005389_reproductive_system_phenotype1.30715661
42MP0005379_endocrine/exocrine_gland_phen1.29261897
43MP0001293_anophthalmia1.28756349
44MP0005645_abnormal_hypothalamus_physiol1.28677943
45MP0000685_abnormal_immune_system1.28578365
46MP0002163_abnormal_gland_morphology1.28222400
47MP0005253_abnormal_eye_physiology1.27839308
48MP0001986_abnormal_taste_sensitivity1.25771894
49MP0003077_abnormal_cell_cycle1.24861173
50MP0003111_abnormal_nucleus_morphology1.22634752
51MP0003186_abnormal_redox_activity1.22344852
52MP0001529_abnormal_vocalization1.22342094
53MP0001968_abnormal_touch/_nociception1.21403927
54MP0002006_tumorigenesis1.20491920
55MP0008995_early_reproductive_senescence1.19899118
56MP0004215_abnormal_myocardial_fiber1.19895741
57MP0001800_abnormal_humoral_immune1.09176337
58MP0001188_hyperpigmentation1.09153816
59MP0002166_altered_tumor_susceptibility1.09121709
60MP0009785_altered_susceptibility_to1.06371824
61MP0001984_abnormal_olfaction1.05240661
62MP0005085_abnormal_gallbladder_physiolo1.04680561
63MP0004742_abnormal_vestibular_system1.01015826
64MP0005310_abnormal_salivary_gland1.00198373
65MP0005075_abnormal_melanosome_morpholog0.99552365
66MP0002148_abnormal_hypersensitivity_rea0.96186127
67MP0005167_abnormal_blood-brain_barrier0.95303584
68MP0003763_abnormal_thymus_physiology0.94791833
69MP0008789_abnormal_olfactory_epithelium0.93179804
70MP0005646_abnormal_pituitary_gland0.92516723
71MP0002405_respiratory_system_inflammati0.91544109
72MP0002938_white_spotting0.91541212
73MP0009697_abnormal_copulation0.91495949
74MP0001661_extended_life_span0.87436258
75MP0005000_abnormal_immune_tolerance0.86933043
76MP0008007_abnormal_cellular_replicative0.86352842
77MP0001919_abnormal_reproductive_system0.85760478
78MP0002277_abnormal_respiratory_mucosa0.85595942
79MP0002210_abnormal_sex_determination0.85568907
80MP0004147_increased_porphyrin_level0.83580719
81MP0008932_abnormal_embryonic_tissue0.83247792
82MP0001764_abnormal_homeostasis0.82436734
83MP0003137_abnormal_impulse_conducting0.80550446
84MP0004782_abnormal_surfactant_physiolog0.80472144
85MP0001119_abnormal_female_reproductive0.80322452
86MP0002234_abnormal_pharynx_morphology0.79989545
87MP0002693_abnormal_pancreas_physiology0.76855080
88MP0005636_abnormal_mineral_homeostasis0.75571147
89MP0002254_reproductive_system_inflammat0.74866438
90MP0001929_abnormal_gametogenesis0.73172783
91MP0000689_abnormal_spleen_morphology0.71553852
92MP0003936_abnormal_reproductive_system0.67913988
93MP0000372_irregular_coat_pigmentation0.65838377
94MP0002272_abnormal_nervous_system0.65596016
95MP0002420_abnormal_adaptive_immunity0.64840396
96MP0003937_abnormal_limbs/digits/tail_de0.64629817
97MP0000703_abnormal_thymus_morphology0.63908059
98MP0000653_abnormal_sex_gland0.63650042
99MP0008873_increased_physiological_sensi0.63164533
100MP0002723_abnormal_immune_serum0.62745635

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.27873907
2Acute necrotizing encephalopathy (HP:0006965)4.03523095
3Lipid accumulation in hepatocytes (HP:0006561)4.00252988
4Mitochondrial inheritance (HP:0001427)3.96165054
5Increased CSF lactate (HP:0002490)3.87655217
6Stomatitis (HP:0010280)3.69068324
7Acute encephalopathy (HP:0006846)3.66222833
8Abnormal mitochondria in muscle tissue (HP:0008316)3.46021962
9Progressive macrocephaly (HP:0004481)3.34275080
10IgG deficiency (HP:0004315)3.21680447
11Hepatocellular necrosis (HP:0001404)3.10064196
12Exertional dyspnea (HP:0002875)3.09546210
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08198922
14Renal Fanconi syndrome (HP:0001994)2.98436818
15Increased serum lactate (HP:0002151)2.94784103
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94385929
17Pancreatic cysts (HP:0001737)2.93588318
183-Methylglutaconic aciduria (HP:0003535)2.88461981
19Molar tooth sign on MRI (HP:0002419)2.88293675
20Abnormality of midbrain morphology (HP:0002418)2.88293675
21Hepatic necrosis (HP:0002605)2.86995791
22Cerebral edema (HP:0002181)2.85269525
23Abnormal rod and cone electroretinograms (HP:0008323)2.69064103
24Colon cancer (HP:0003003)2.66133978
25Congenital, generalized hypertrichosis (HP:0004540)2.63650309
26Methylmalonic acidemia (HP:0002912)2.58243598
27Abnormality of the pons (HP:0007361)2.57995819
28Abnormality of the ileum (HP:0001549)2.57734199
29Abnormality of the labia minora (HP:0012880)2.53078013
30Meckel diverticulum (HP:0002245)2.52934653
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50573420
32True hermaphroditism (HP:0010459)2.50004148
33Nephronophthisis (HP:0000090)2.48994594
34Congenital stationary night blindness (HP:0007642)2.48875975
35Increased intramyocellular lipid droplets (HP:0012240)2.48203737
36Supernumerary spleens (HP:0009799)2.46524481
37Lactic acidosis (HP:0003128)2.40103847
38Respiratory difficulties (HP:0002880)2.38895365
39Abnormal biliary tract physiology (HP:0012439)2.38825644
40Bile duct proliferation (HP:0001408)2.38825644
41Severe combined immunodeficiency (HP:0004430)2.38310372
42Pendular nystagmus (HP:0012043)2.37228974
43Optic disc pallor (HP:0000543)2.29822954
44Pancreatic fibrosis (HP:0100732)2.28420766
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.27928454
46Hypoplasia of the pons (HP:0012110)2.24926122
47Lethargy (HP:0001254)2.23884087
48Respiratory failure (HP:0002878)2.23148455
49Exercise intolerance (HP:0003546)2.22241951
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21094736
51Large for gestational age (HP:0001520)2.20559464
52Methylmalonic aciduria (HP:0012120)2.19370444
53Abnormality of the preputium (HP:0100587)2.12397886
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.12203405
55Absent/shortened dynein arms (HP:0200106)2.12203405
56Glycosuria (HP:0003076)2.10832774
57Abnormality of urine glucose concentration (HP:0011016)2.10832774
58Increased muscle lipid content (HP:0009058)2.09390448
59Hyperglycinuria (HP:0003108)2.08130018
60Chromsome breakage (HP:0040012)2.06894768
61Constricted visual fields (HP:0001133)2.06758631
62Hyperglycinemia (HP:0002154)2.05590531
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.03917383
64Panhypogammaglobulinemia (HP:0003139)2.03197030
65Abolished electroretinogram (ERG) (HP:0000550)2.02412266
66Attenuation of retinal blood vessels (HP:0007843)2.01249992
67Abnormality of glycine metabolism (HP:0010895)1.98569490
68Abnormality of serine family amino acid metabolism (HP:0010894)1.98569490
69Abnormality of the renal medulla (HP:0100957)1.97336463
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96605194
71Abnormality of alanine metabolism (HP:0010916)1.96605194
72Hyperalaninemia (HP:0003348)1.96605194
73Abnormality of the renal collecting system (HP:0004742)1.96346077
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95420319
75Abnormality of the renal cortex (HP:0011035)1.95389572
76Asplenia (HP:0001746)1.93972912
77Duplicated collecting system (HP:0000081)1.92759332
78Renal cortical cysts (HP:0000803)1.91647418
79Leukodystrophy (HP:0002415)1.91444037
80Increased IgM level (HP:0003496)1.89801597
81Abnormality of chromosome stability (HP:0003220)1.87704606
82Decreased central vision (HP:0007663)1.87698175
83Thyroiditis (HP:0100646)1.86987158
84Short tibia (HP:0005736)1.86431075
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.85614664
86Clubbing of toes (HP:0100760)1.84082870
87Abnormality of serum amino acid levels (HP:0003112)1.82283426
88Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81851324
89Aplasia/hypoplasia of the uterus (HP:0008684)1.81179256
90Combined immunodeficiency (HP:0005387)1.80683539
91Carpal bone hypoplasia (HP:0001498)1.80495739
92Abnormal lung lobation (HP:0002101)1.79993646
93Abnormality of DNA repair (HP:0003254)1.79727060
94Pancytopenia (HP:0001876)1.79361713
95Hyperphosphaturia (HP:0003109)1.78217536
96Horseshoe kidney (HP:0000085)1.77757921
97Abnormality of methionine metabolism (HP:0010901)1.77595663
98Abnormal respiratory motile cilium morphology (HP:0005938)1.76876994
99Abnormal respiratory epithelium morphology (HP:0012253)1.76876994
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76048024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.11542450
2TSSK63.76704550
3EIF2AK33.59634793
4VRK23.19370534
5EIF2AK13.06305638
6NUAK13.00720042
7ZAK2.94055876
8PBK2.88109494
9BUB12.76543438
10NME12.65506081
11SRPK12.48587399
12TXK2.37253663
13TRIM282.11688702
14MKNK22.02950620
15PLK31.98153702
16ADRBK21.84898718
17STK391.84544044
18MKNK11.84133785
19VRK11.81067516
20MAP4K21.79333262
21NEK11.76271334
22FRK1.75068774
23WNK31.71002751
24WNK41.68916398
25GRK11.64106142
26STK161.63611581
27TIE11.47666365
28TAF11.47505036
29TNIK1.41022107
30PLK41.37549712
31TLK11.33402354
32OXSR11.32471533
33EIF2AK21.30586479
34BMPR1B1.25023005
35CDC71.20316705
36BCKDK1.20221895
37ACVR1B0.98645706
38NLK0.96191095
39STK38L0.93733739
40TEC0.92998073
41PLK20.91176200
42PLK10.88293920
43CSNK1A1L0.87881240
44DYRK20.80599188
45CSNK1G10.77543067
46KDR0.74784006
47TAOK30.74752040
48PASK0.73850361
49TTK0.73446411
50CSNK1G30.71205665
51ATR0.67369977
52ITK0.61807013
53STK40.61569143
54BRSK20.60941024
55ALK0.60626495
56IKBKB0.58881349
57MAP3K120.55791314
58MAP2K60.54648257
59CSNK1G20.54549618
60PIK3CG0.53813689
61AURKB0.52934404
62PRKCQ0.52630411
63RPS6KA50.52602299
64TGFBR10.51444197
65PDK20.50264760
66BCR0.49607739
67MAP3K40.45225459
68INSRR0.44436876
69ERBB30.43765862
70CSNK2A20.42877616
71CSNK2A10.42203019
72DAPK10.41944767
73CLK10.41596369
74STK30.40189410
75PRKCE0.39574876
76WEE10.39191742
77ADRBK10.38707103
78MAPKAPK50.35085084
79RPS6KA40.35057651
80ATM0.35041638
81DAPK20.34596504
82TNK20.33458844
83PHKG10.33320146
84PHKG20.33320146
85PAK30.31947578
86PAK40.31307466
87CHEK20.29696967
88CSNK1E0.29259556
89CHEK10.27990615
90GRK70.27826479
91PIK3CA0.26924202
92MAP4K10.25759512
93LCK0.24337721
94STK240.24302928
95BRD40.23644023
96IGF1R0.22253484
97AKT30.20810283
98CDK70.20611583
99PRKCG0.20392113
100PRKCI0.19878337

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88601017
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36590066
3Protein export_Homo sapiens_hsa030602.99716037
4RNA polymerase_Homo sapiens_hsa030202.98159399
5Oxidative phosphorylation_Homo sapiens_hsa001902.53005395
6Asthma_Homo sapiens_hsa053102.24074779
7Parkinsons disease_Homo sapiens_hsa050122.22624628
8Allograft rejection_Homo sapiens_hsa053302.22120717
9Mismatch repair_Homo sapiens_hsa034302.14702921
10Primary immunodeficiency_Homo sapiens_hsa053402.11525165
11DNA replication_Homo sapiens_hsa030302.05234312
12Basal transcription factors_Homo sapiens_hsa030222.02583151
13Autoimmune thyroid disease_Homo sapiens_hsa053201.96169479
14RNA transport_Homo sapiens_hsa030131.93747973
15Ribosome_Homo sapiens_hsa030101.91600336
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91330731
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88193619
18Homologous recombination_Homo sapiens_hsa034401.87754457
19RNA degradation_Homo sapiens_hsa030181.81776292
20Propanoate metabolism_Homo sapiens_hsa006401.80849848
21Spliceosome_Homo sapiens_hsa030401.79987977
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.78901139
23One carbon pool by folate_Homo sapiens_hsa006701.75613065
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73725699
25Huntingtons disease_Homo sapiens_hsa050161.65117374
26Non-homologous end-joining_Homo sapiens_hsa034501.60605427
27Nucleotide excision repair_Homo sapiens_hsa034201.58640096
28Vitamin B6 metabolism_Homo sapiens_hsa007501.51333087
29Fanconi anemia pathway_Homo sapiens_hsa034601.43607194
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39689818
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38802619
32Caffeine metabolism_Homo sapiens_hsa002321.35837139
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.34890824
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33561869
35Pyrimidine metabolism_Homo sapiens_hsa002401.33192293
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30227628
37Alzheimers disease_Homo sapiens_hsa050101.20874015
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18462113
39Purine metabolism_Homo sapiens_hsa002301.17310881
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13024242
41Type I diabetes mellitus_Homo sapiens_hsa049401.11270816
42Linoleic acid metabolism_Homo sapiens_hsa005911.09979130
43Graft-versus-host disease_Homo sapiens_hsa053321.07626524
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04018636
45Phototransduction_Homo sapiens_hsa047441.02555665
46Antigen processing and presentation_Homo sapiens_hsa046120.96886200
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96258007
48Peroxisome_Homo sapiens_hsa041460.96159067
49Base excision repair_Homo sapiens_hsa034100.94695471
50Butanoate metabolism_Homo sapiens_hsa006500.93850885
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87998646
52Hematopoietic cell lineage_Homo sapiens_hsa046400.86681042
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82161504
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81648696
55Steroid biosynthesis_Homo sapiens_hsa001000.80430533
56Sulfur metabolism_Homo sapiens_hsa009200.79797324
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78598162
58Tryptophan metabolism_Homo sapiens_hsa003800.75675348
59Regulation of autophagy_Homo sapiens_hsa041400.74238018
60T cell receptor signaling pathway_Homo sapiens_hsa046600.72783763
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68759105
62Fatty acid degradation_Homo sapiens_hsa000710.63705218
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63482667
64Nitrogen metabolism_Homo sapiens_hsa009100.62852095
65Glutathione metabolism_Homo sapiens_hsa004800.62040854
66Metabolic pathways_Homo sapiens_hsa011000.60370869
67Pyruvate metabolism_Homo sapiens_hsa006200.57877867
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57121833
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56981175
70Cardiac muscle contraction_Homo sapiens_hsa042600.56942026
71Retinol metabolism_Homo sapiens_hsa008300.55858162
72Fatty acid elongation_Homo sapiens_hsa000620.54558742
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54027183
74Rheumatoid arthritis_Homo sapiens_hsa053230.53097879
75Chemical carcinogenesis_Homo sapiens_hsa052040.52670333
76Cell cycle_Homo sapiens_hsa041100.51345577
77mRNA surveillance pathway_Homo sapiens_hsa030150.49579960
78Folate biosynthesis_Homo sapiens_hsa007900.48702441
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.48557987
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46622139
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46157296
82Vitamin digestion and absorption_Homo sapiens_hsa049770.44631282
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44547744
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.43913313
85beta-Alanine metabolism_Homo sapiens_hsa004100.43288504
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41013880
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.40609752
88Fat digestion and absorption_Homo sapiens_hsa049750.40150154
89Fatty acid metabolism_Homo sapiens_hsa012120.39418815
90Ether lipid metabolism_Homo sapiens_hsa005650.38770014
91Epstein-Barr virus infection_Homo sapiens_hsa051690.38480476
92Measles_Homo sapiens_hsa051620.38058828
93p53 signaling pathway_Homo sapiens_hsa041150.37054317
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.33545571
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31741586
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.29663965
97Selenocompound metabolism_Homo sapiens_hsa004500.29431498
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.29026327
99Olfactory transduction_Homo sapiens_hsa047400.26155974
100Arachidonic acid metabolism_Homo sapiens_hsa005900.24612463

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »