

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.64228435 |
| 2 | proteasome assembly (GO:0043248) | 5.28644949 |
| 3 | rRNA modification (GO:0000154) | 5.08759430 |
| 4 | rRNA methylation (GO:0031167) | 4.95578467 |
| 5 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.91031221 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.83376088 |
| 7 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.64409331 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.15621562 |
| 9 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.10364466 |
| 10 | regulation of immunoglobulin secretion (GO:0051023) | 4.09787850 |
| 11 | cullin deneddylation (GO:0010388) | 4.06224029 |
| 12 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.05665091 |
| 13 | protein deneddylation (GO:0000338) | 3.98132070 |
| 14 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.85847824 |
| 15 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.80279583 |
| 16 | positive regulation of isotype switching (GO:0045830) | 3.71600555 |
| 17 | ribosome assembly (GO:0042255) | 3.70857561 |
| 18 | respiratory chain complex IV assembly (GO:0008535) | 3.68876817 |
| 19 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.68115225 |
| 20 | ATP synthesis coupled proton transport (GO:0015986) | 3.68084099 |
| 21 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.68084099 |
| 22 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.67054650 |
| 23 | mitochondrial RNA metabolic process (GO:0000959) | 3.66430572 |
| 24 | positive regulation of DNA recombination (GO:0045911) | 3.65643746 |
| 25 | regulation of chronic inflammatory response (GO:0002676) | 3.63577818 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.63383981 |
| 27 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61968487 |
| 28 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.61115432 |
| 29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.60461657 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.60461657 |
| 31 | protein complex biogenesis (GO:0070271) | 3.57935101 |
| 32 | transcription from mitochondrial promoter (GO:0006390) | 3.56671591 |
| 33 | maturation of 5.8S rRNA (GO:0000460) | 3.55112836 |
| 34 | cytidine deamination (GO:0009972) | 3.54954769 |
| 35 | cytidine metabolic process (GO:0046087) | 3.54954769 |
| 36 | cytidine catabolic process (GO:0006216) | 3.54954769 |
| 37 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.50115376 |
| 38 | protein neddylation (GO:0045116) | 3.48630109 |
| 39 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.48105441 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.48015307 |
| 41 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.48015307 |
| 42 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.48015307 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.44999601 |
| 44 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.41342381 |
| 45 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.41342381 |
| 46 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.40376807 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.37584803 |
| 48 | negative regulation of ligase activity (GO:0051352) | 3.37584803 |
| 49 | termination of RNA polymerase I transcription (GO:0006363) | 3.37155836 |
| 50 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.35221767 |
| 51 | NADH dehydrogenase complex assembly (GO:0010257) | 3.35221767 |
| 52 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.35221767 |
| 53 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.31261413 |
| 54 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.31261413 |
| 55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.28029514 |
| 56 | GTP biosynthetic process (GO:0006183) | 3.17755496 |
| 57 | cytochrome complex assembly (GO:0017004) | 3.14930897 |
| 58 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.13102670 |
| 59 | isotype switching (GO:0045190) | 3.13102670 |
| 60 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.13102670 |
| 61 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12866737 |
| 62 | chromatin remodeling at centromere (GO:0031055) | 3.12470809 |
| 63 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.10958789 |
| 64 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.09905171 |
| 65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.09905171 |
| 66 | rRNA processing (GO:0006364) | 3.07692247 |
| 67 | regulation of podosome assembly (GO:0071801) | 3.04899118 |
| 68 | protein targeting to mitochondrion (GO:0006626) | 3.02614869 |
| 69 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.02186708 |
| 70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.00429803 |
| 71 | rRNA metabolic process (GO:0016072) | 3.00251553 |
| 72 | CENP-A containing nucleosome assembly (GO:0034080) | 2.98587499 |
| 73 | DNA double-strand break processing (GO:0000729) | 2.98295840 |
| 74 | replication fork processing (GO:0031297) | 2.97257013 |
| 75 | histone mRNA metabolic process (GO:0008334) | 2.97119573 |
| 76 | positive regulation of immunoglobulin production (GO:0002639) | 2.93536528 |
| 77 | positive regulation of interleukin-17 production (GO:0032740) | 2.89920872 |
| 78 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.88559303 |
| 79 | positive regulation of ligase activity (GO:0051351) | 2.87879367 |
| 80 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.85986601 |
| 81 | establishment of protein localization to mitochondrion (GO:0072655) | 2.83033687 |
| 82 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.81766578 |
| 83 | ribosome biogenesis (GO:0042254) | 2.81225242 |
| 84 | viral mRNA export from host cell nucleus (GO:0046784) | 2.80618067 |
| 85 | tRNA processing (GO:0008033) | 2.80504339 |
| 86 | IMP biosynthetic process (GO:0006188) | 2.78399753 |
| 87 | tRNA metabolic process (GO:0006399) | 2.77876483 |
| 88 | protein localization to mitochondrion (GO:0070585) | 2.77260669 |
| 89 | UTP biosynthetic process (GO:0006228) | 2.74603111 |
| 90 | amino acid activation (GO:0043038) | 2.73915086 |
| 91 | tRNA aminoacylation (GO:0043039) | 2.73915086 |
| 92 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.73517563 |
| 93 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.73517563 |
| 94 | spliceosomal snRNP assembly (GO:0000387) | 2.72442792 |
| 95 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.72401435 |
| 96 | recombinational repair (GO:0000725) | 2.70548561 |
| 97 | ncRNA metabolic process (GO:0034660) | 2.69906360 |
| 98 | positive regulation of cell cycle arrest (GO:0071158) | 2.69695787 |
| 99 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.69618300 |
| 100 | double-strand break repair via homologous recombination (GO:0000724) | 2.69168110 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.92346865 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.49737298 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.96969524 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.47276656 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.15778446 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01228967 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.96887278 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.79537844 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.74497795 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.73546221 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.72414906 |
| 12 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.58850928 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.57555217 |
| 14 | VDR_22108803_ChIP-Seq_LS180_Human | 2.51611156 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38968855 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.37711174 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.35614969 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32977854 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.28769645 |
| 20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.26942674 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.25839138 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09672222 |
| 23 | EWS_26573619_Chip-Seq_HEK293_Human | 2.04889370 |
| 24 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.02666299 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.96099053 |
| 26 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.93454867 |
| 27 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.84129695 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.81440833 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.81279235 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.78440213 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.74313724 |
| 32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.72290738 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.71443607 |
| 34 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.70307112 |
| 35 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.66546353 |
| 36 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.65202466 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57685335 |
| 38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56191255 |
| 39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.53449883 |
| 40 | FUS_26573619_Chip-Seq_HEK293_Human | 1.45809254 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.44734651 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.41565197 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41386291 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41005193 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.37251389 |
| 46 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.36468176 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.35393518 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.31579084 |
| 49 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.30218721 |
| 50 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.30108944 |
| 51 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28217270 |
| 52 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27607647 |
| 53 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.21870050 |
| 54 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.21412801 |
| 55 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.20692702 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.17104214 |
| 57 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.17051779 |
| 58 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.16513374 |
| 59 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.15866375 |
| 60 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.15866375 |
| 61 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.15366176 |
| 62 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15134167 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13684782 |
| 64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.13394689 |
| 65 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.11648237 |
| 66 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11385875 |
| 67 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.11325095 |
| 68 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.11325095 |
| 69 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.10668787 |
| 70 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.09454145 |
| 71 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.08724189 |
| 72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06913087 |
| 73 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.06655899 |
| 74 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.06058315 |
| 75 | GATA3_26560356_Chip-Seq_TH2_Human | 1.03145524 |
| 76 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.02634080 |
| 77 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.02634080 |
| 78 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.02408575 |
| 79 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.02209492 |
| 80 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.02066968 |
| 81 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.02050641 |
| 82 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.02036329 |
| 83 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01713905 |
| 84 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.01265058 |
| 85 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.00539319 |
| 86 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.00393024 |
| 87 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.96137406 |
| 88 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95716282 |
| 89 | AR_20517297_ChIP-Seq_VCAP_Human | 0.94894811 |
| 90 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93791945 |
| 91 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.92556502 |
| 92 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.92477401 |
| 93 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.87589868 |
| 94 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.87056142 |
| 95 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.86952699 |
| 96 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.86672991 |
| 97 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.86512168 |
| 98 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.86181655 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.84584563 |
| 100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.84415264 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001873_stomach_inflammation | 2.97495889 |
| 2 | MP0001835_abnormal_antigen_presentation | 2.90837275 |
| 3 | MP0008875_abnormal_xenobiotic_pharmacok | 2.84795685 |
| 4 | MP0003195_calcinosis | 2.84537013 |
| 5 | MP0003786_premature_aging | 2.74219713 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.71325306 |
| 7 | MP0008057_abnormal_DNA_replication | 2.65937304 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.59328609 |
| 9 | MP0002102_abnormal_ear_morphology | 2.54759120 |
| 10 | MP0008058_abnormal_DNA_repair | 2.49828261 |
| 11 | MP0005671_abnormal_response_to | 2.42600260 |
| 12 | MP0003646_muscle_fatigue | 2.40225283 |
| 13 | MP0008872_abnormal_physiological_respon | 2.35856008 |
| 14 | MP0003693_abnormal_embryo_hatching | 2.30098643 |
| 15 | MP0010094_abnormal_chromosome_stability | 2.29040230 |
| 16 | MP0001348_abnormal_lacrimal_gland | 2.18302233 |
| 17 | MP0005377_hearing/vestibular/ear_phenot | 2.15333113 |
| 18 | MP0003878_abnormal_ear_physiology | 2.15333113 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 2.00702627 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.89300204 |
| 21 | MP0006292_abnormal_olfactory_placode | 1.82505815 |
| 22 | MP0005084_abnormal_gallbladder_morpholo | 1.81889840 |
| 23 | MP0002837_dystrophic_cardiac_calcinosis | 1.76496027 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 1.73961183 |
| 25 | MP0003718_maternal_effect | 1.68948636 |
| 26 | MP0003890_abnormal_embryonic-extraembry | 1.63114811 |
| 27 | MP0006035_abnormal_mitochondrial_morpho | 1.63053596 |
| 28 | MP0002138_abnormal_hepatobiliary_system | 1.59372634 |
| 29 | MP0005551_abnormal_eye_electrophysiolog | 1.54883971 |
| 30 | MP0004145_abnormal_muscle_electrophysio | 1.48384648 |
| 31 | MP0003011_delayed_dark_adaptation | 1.47629497 |
| 32 | MP0001485_abnormal_pinna_reflex | 1.46716871 |
| 33 | MP0002160_abnormal_reproductive_system | 1.46285991 |
| 34 | MP0006082_CNS_inflammation | 1.43876393 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.40207194 |
| 36 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37236915 |
| 37 | MP0002736_abnormal_nociception_after | 1.34143481 |
| 38 | MP0005387_immune_system_phenotype | 1.32858924 |
| 39 | MP0001790_abnormal_immune_system | 1.32858924 |
| 40 | MP0001853_heart_inflammation | 1.31154064 |
| 41 | MP0005389_reproductive_system_phenotype | 1.30715661 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.29261897 |
| 43 | MP0001293_anophthalmia | 1.28756349 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.28677943 |
| 45 | MP0000685_abnormal_immune_system | 1.28578365 |
| 46 | MP0002163_abnormal_gland_morphology | 1.28222400 |
| 47 | MP0005253_abnormal_eye_physiology | 1.27839308 |
| 48 | MP0001986_abnormal_taste_sensitivity | 1.25771894 |
| 49 | MP0003077_abnormal_cell_cycle | 1.24861173 |
| 50 | MP0003111_abnormal_nucleus_morphology | 1.22634752 |
| 51 | MP0003186_abnormal_redox_activity | 1.22344852 |
| 52 | MP0001529_abnormal_vocalization | 1.22342094 |
| 53 | MP0001968_abnormal_touch/_nociception | 1.21403927 |
| 54 | MP0002006_tumorigenesis | 1.20491920 |
| 55 | MP0008995_early_reproductive_senescence | 1.19899118 |
| 56 | MP0004215_abnormal_myocardial_fiber | 1.19895741 |
| 57 | MP0001800_abnormal_humoral_immune | 1.09176337 |
| 58 | MP0001188_hyperpigmentation | 1.09153816 |
| 59 | MP0002166_altered_tumor_susceptibility | 1.09121709 |
| 60 | MP0009785_altered_susceptibility_to | 1.06371824 |
| 61 | MP0001984_abnormal_olfaction | 1.05240661 |
| 62 | MP0005085_abnormal_gallbladder_physiolo | 1.04680561 |
| 63 | MP0004742_abnormal_vestibular_system | 1.01015826 |
| 64 | MP0005310_abnormal_salivary_gland | 1.00198373 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 0.99552365 |
| 66 | MP0002148_abnormal_hypersensitivity_rea | 0.96186127 |
| 67 | MP0005167_abnormal_blood-brain_barrier | 0.95303584 |
| 68 | MP0003763_abnormal_thymus_physiology | 0.94791833 |
| 69 | MP0008789_abnormal_olfactory_epithelium | 0.93179804 |
| 70 | MP0005646_abnormal_pituitary_gland | 0.92516723 |
| 71 | MP0002405_respiratory_system_inflammati | 0.91544109 |
| 72 | MP0002938_white_spotting | 0.91541212 |
| 73 | MP0009697_abnormal_copulation | 0.91495949 |
| 74 | MP0001661_extended_life_span | 0.87436258 |
| 75 | MP0005000_abnormal_immune_tolerance | 0.86933043 |
| 76 | MP0008007_abnormal_cellular_replicative | 0.86352842 |
| 77 | MP0001919_abnormal_reproductive_system | 0.85760478 |
| 78 | MP0002277_abnormal_respiratory_mucosa | 0.85595942 |
| 79 | MP0002210_abnormal_sex_determination | 0.85568907 |
| 80 | MP0004147_increased_porphyrin_level | 0.83580719 |
| 81 | MP0008932_abnormal_embryonic_tissue | 0.83247792 |
| 82 | MP0001764_abnormal_homeostasis | 0.82436734 |
| 83 | MP0003137_abnormal_impulse_conducting | 0.80550446 |
| 84 | MP0004782_abnormal_surfactant_physiolog | 0.80472144 |
| 85 | MP0001119_abnormal_female_reproductive | 0.80322452 |
| 86 | MP0002234_abnormal_pharynx_morphology | 0.79989545 |
| 87 | MP0002693_abnormal_pancreas_physiology | 0.76855080 |
| 88 | MP0005636_abnormal_mineral_homeostasis | 0.75571147 |
| 89 | MP0002254_reproductive_system_inflammat | 0.74866438 |
| 90 | MP0001929_abnormal_gametogenesis | 0.73172783 |
| 91 | MP0000689_abnormal_spleen_morphology | 0.71553852 |
| 92 | MP0003936_abnormal_reproductive_system | 0.67913988 |
| 93 | MP0000372_irregular_coat_pigmentation | 0.65838377 |
| 94 | MP0002272_abnormal_nervous_system | 0.65596016 |
| 95 | MP0002420_abnormal_adaptive_immunity | 0.64840396 |
| 96 | MP0003937_abnormal_limbs/digits/tail_de | 0.64629817 |
| 97 | MP0000703_abnormal_thymus_morphology | 0.63908059 |
| 98 | MP0000653_abnormal_sex_gland | 0.63650042 |
| 99 | MP0008873_increased_physiological_sensi | 0.63164533 |
| 100 | MP0002723_abnormal_immune_serum | 0.62745635 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.27873907 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.03523095 |
| 3 | Lipid accumulation in hepatocytes (HP:0006561) | 4.00252988 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.96165054 |
| 5 | Increased CSF lactate (HP:0002490) | 3.87655217 |
| 6 | Stomatitis (HP:0010280) | 3.69068324 |
| 7 | Acute encephalopathy (HP:0006846) | 3.66222833 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.46021962 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.34275080 |
| 10 | IgG deficiency (HP:0004315) | 3.21680447 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.10064196 |
| 12 | Exertional dyspnea (HP:0002875) | 3.09546210 |
| 13 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.08198922 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 2.98436818 |
| 15 | Increased serum lactate (HP:0002151) | 2.94784103 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.94385929 |
| 17 | Pancreatic cysts (HP:0001737) | 2.93588318 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 2.88461981 |
| 19 | Molar tooth sign on MRI (HP:0002419) | 2.88293675 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 2.88293675 |
| 21 | Hepatic necrosis (HP:0002605) | 2.86995791 |
| 22 | Cerebral edema (HP:0002181) | 2.85269525 |
| 23 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.69064103 |
| 24 | Colon cancer (HP:0003003) | 2.66133978 |
| 25 | Congenital, generalized hypertrichosis (HP:0004540) | 2.63650309 |
| 26 | Methylmalonic acidemia (HP:0002912) | 2.58243598 |
| 27 | Abnormality of the pons (HP:0007361) | 2.57995819 |
| 28 | Abnormality of the ileum (HP:0001549) | 2.57734199 |
| 29 | Abnormality of the labia minora (HP:0012880) | 2.53078013 |
| 30 | Meckel diverticulum (HP:0002245) | 2.52934653 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.50573420 |
| 32 | True hermaphroditism (HP:0010459) | 2.50004148 |
| 33 | Nephronophthisis (HP:0000090) | 2.48994594 |
| 34 | Congenital stationary night blindness (HP:0007642) | 2.48875975 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.48203737 |
| 36 | Supernumerary spleens (HP:0009799) | 2.46524481 |
| 37 | Lactic acidosis (HP:0003128) | 2.40103847 |
| 38 | Respiratory difficulties (HP:0002880) | 2.38895365 |
| 39 | Abnormal biliary tract physiology (HP:0012439) | 2.38825644 |
| 40 | Bile duct proliferation (HP:0001408) | 2.38825644 |
| 41 | Severe combined immunodeficiency (HP:0004430) | 2.38310372 |
| 42 | Pendular nystagmus (HP:0012043) | 2.37228974 |
| 43 | Optic disc pallor (HP:0000543) | 2.29822954 |
| 44 | Pancreatic fibrosis (HP:0100732) | 2.28420766 |
| 45 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.27928454 |
| 46 | Hypoplasia of the pons (HP:0012110) | 2.24926122 |
| 47 | Lethargy (HP:0001254) | 2.23884087 |
| 48 | Respiratory failure (HP:0002878) | 2.23148455 |
| 49 | Exercise intolerance (HP:0003546) | 2.22241951 |
| 50 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.21094736 |
| 51 | Large for gestational age (HP:0001520) | 2.20559464 |
| 52 | Methylmalonic aciduria (HP:0012120) | 2.19370444 |
| 53 | Abnormality of the preputium (HP:0100587) | 2.12397886 |
| 54 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.12203405 |
| 55 | Absent/shortened dynein arms (HP:0200106) | 2.12203405 |
| 56 | Glycosuria (HP:0003076) | 2.10832774 |
| 57 | Abnormality of urine glucose concentration (HP:0011016) | 2.10832774 |
| 58 | Increased muscle lipid content (HP:0009058) | 2.09390448 |
| 59 | Hyperglycinuria (HP:0003108) | 2.08130018 |
| 60 | Chromsome breakage (HP:0040012) | 2.06894768 |
| 61 | Constricted visual fields (HP:0001133) | 2.06758631 |
| 62 | Hyperglycinemia (HP:0002154) | 2.05590531 |
| 63 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.03917383 |
| 64 | Panhypogammaglobulinemia (HP:0003139) | 2.03197030 |
| 65 | Abolished electroretinogram (ERG) (HP:0000550) | 2.02412266 |
| 66 | Attenuation of retinal blood vessels (HP:0007843) | 2.01249992 |
| 67 | Abnormality of glycine metabolism (HP:0010895) | 1.98569490 |
| 68 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.98569490 |
| 69 | Abnormality of the renal medulla (HP:0100957) | 1.97336463 |
| 70 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.96605194 |
| 71 | Abnormality of alanine metabolism (HP:0010916) | 1.96605194 |
| 72 | Hyperalaninemia (HP:0003348) | 1.96605194 |
| 73 | Abnormality of the renal collecting system (HP:0004742) | 1.96346077 |
| 74 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.95420319 |
| 75 | Abnormality of the renal cortex (HP:0011035) | 1.95389572 |
| 76 | Asplenia (HP:0001746) | 1.93972912 |
| 77 | Duplicated collecting system (HP:0000081) | 1.92759332 |
| 78 | Renal cortical cysts (HP:0000803) | 1.91647418 |
| 79 | Leukodystrophy (HP:0002415) | 1.91444037 |
| 80 | Increased IgM level (HP:0003496) | 1.89801597 |
| 81 | Abnormality of chromosome stability (HP:0003220) | 1.87704606 |
| 82 | Decreased central vision (HP:0007663) | 1.87698175 |
| 83 | Thyroiditis (HP:0100646) | 1.86987158 |
| 84 | Short tibia (HP:0005736) | 1.86431075 |
| 85 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.85614664 |
| 86 | Clubbing of toes (HP:0100760) | 1.84082870 |
| 87 | Abnormality of serum amino acid levels (HP:0003112) | 1.82283426 |
| 88 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.81851324 |
| 89 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.81179256 |
| 90 | Combined immunodeficiency (HP:0005387) | 1.80683539 |
| 91 | Carpal bone hypoplasia (HP:0001498) | 1.80495739 |
| 92 | Abnormal lung lobation (HP:0002101) | 1.79993646 |
| 93 | Abnormality of DNA repair (HP:0003254) | 1.79727060 |
| 94 | Pancytopenia (HP:0001876) | 1.79361713 |
| 95 | Hyperphosphaturia (HP:0003109) | 1.78217536 |
| 96 | Horseshoe kidney (HP:0000085) | 1.77757921 |
| 97 | Abnormality of methionine metabolism (HP:0010901) | 1.77595663 |
| 98 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.76876994 |
| 99 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.76876994 |
| 100 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.76048024 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 4.11542450 |
| 2 | TSSK6 | 3.76704550 |
| 3 | EIF2AK3 | 3.59634793 |
| 4 | VRK2 | 3.19370534 |
| 5 | EIF2AK1 | 3.06305638 |
| 6 | NUAK1 | 3.00720042 |
| 7 | ZAK | 2.94055876 |
| 8 | PBK | 2.88109494 |
| 9 | BUB1 | 2.76543438 |
| 10 | NME1 | 2.65506081 |
| 11 | SRPK1 | 2.48587399 |
| 12 | TXK | 2.37253663 |
| 13 | TRIM28 | 2.11688702 |
| 14 | MKNK2 | 2.02950620 |
| 15 | PLK3 | 1.98153702 |
| 16 | ADRBK2 | 1.84898718 |
| 17 | STK39 | 1.84544044 |
| 18 | MKNK1 | 1.84133785 |
| 19 | VRK1 | 1.81067516 |
| 20 | MAP4K2 | 1.79333262 |
| 21 | NEK1 | 1.76271334 |
| 22 | FRK | 1.75068774 |
| 23 | WNK3 | 1.71002751 |
| 24 | WNK4 | 1.68916398 |
| 25 | GRK1 | 1.64106142 |
| 26 | STK16 | 1.63611581 |
| 27 | TIE1 | 1.47666365 |
| 28 | TAF1 | 1.47505036 |
| 29 | TNIK | 1.41022107 |
| 30 | PLK4 | 1.37549712 |
| 31 | TLK1 | 1.33402354 |
| 32 | OXSR1 | 1.32471533 |
| 33 | EIF2AK2 | 1.30586479 |
| 34 | BMPR1B | 1.25023005 |
| 35 | CDC7 | 1.20316705 |
| 36 | BCKDK | 1.20221895 |
| 37 | ACVR1B | 0.98645706 |
| 38 | NLK | 0.96191095 |
| 39 | STK38L | 0.93733739 |
| 40 | TEC | 0.92998073 |
| 41 | PLK2 | 0.91176200 |
| 42 | PLK1 | 0.88293920 |
| 43 | CSNK1A1L | 0.87881240 |
| 44 | DYRK2 | 0.80599188 |
| 45 | CSNK1G1 | 0.77543067 |
| 46 | KDR | 0.74784006 |
| 47 | TAOK3 | 0.74752040 |
| 48 | PASK | 0.73850361 |
| 49 | TTK | 0.73446411 |
| 50 | CSNK1G3 | 0.71205665 |
| 51 | ATR | 0.67369977 |
| 52 | ITK | 0.61807013 |
| 53 | STK4 | 0.61569143 |
| 54 | BRSK2 | 0.60941024 |
| 55 | ALK | 0.60626495 |
| 56 | IKBKB | 0.58881349 |
| 57 | MAP3K12 | 0.55791314 |
| 58 | MAP2K6 | 0.54648257 |
| 59 | CSNK1G2 | 0.54549618 |
| 60 | PIK3CG | 0.53813689 |
| 61 | AURKB | 0.52934404 |
| 62 | PRKCQ | 0.52630411 |
| 63 | RPS6KA5 | 0.52602299 |
| 64 | TGFBR1 | 0.51444197 |
| 65 | PDK2 | 0.50264760 |
| 66 | BCR | 0.49607739 |
| 67 | MAP3K4 | 0.45225459 |
| 68 | INSRR | 0.44436876 |
| 69 | ERBB3 | 0.43765862 |
| 70 | CSNK2A2 | 0.42877616 |
| 71 | CSNK2A1 | 0.42203019 |
| 72 | DAPK1 | 0.41944767 |
| 73 | CLK1 | 0.41596369 |
| 74 | STK3 | 0.40189410 |
| 75 | PRKCE | 0.39574876 |
| 76 | WEE1 | 0.39191742 |
| 77 | ADRBK1 | 0.38707103 |
| 78 | MAPKAPK5 | 0.35085084 |
| 79 | RPS6KA4 | 0.35057651 |
| 80 | ATM | 0.35041638 |
| 81 | DAPK2 | 0.34596504 |
| 82 | TNK2 | 0.33458844 |
| 83 | PHKG1 | 0.33320146 |
| 84 | PHKG2 | 0.33320146 |
| 85 | PAK3 | 0.31947578 |
| 86 | PAK4 | 0.31307466 |
| 87 | CHEK2 | 0.29696967 |
| 88 | CSNK1E | 0.29259556 |
| 89 | CHEK1 | 0.27990615 |
| 90 | GRK7 | 0.27826479 |
| 91 | PIK3CA | 0.26924202 |
| 92 | MAP4K1 | 0.25759512 |
| 93 | LCK | 0.24337721 |
| 94 | STK24 | 0.24302928 |
| 95 | BRD4 | 0.23644023 |
| 96 | IGF1R | 0.22253484 |
| 97 | AKT3 | 0.20810283 |
| 98 | CDK7 | 0.20611583 |
| 99 | PRKCG | 0.20392113 |
| 100 | PRKCI | 0.19878337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.88601017 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.36590066 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.99716037 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.98159399 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.53005395 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.24074779 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22624628 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.22120717 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.14702921 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.11525165 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 2.05234312 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.02583151 |
| 13 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.96169479 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 1.93747973 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 1.91600336 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.91330731 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.88193619 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.87754457 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.81776292 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.80849848 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.79987977 |
| 22 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.78901139 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.75613065 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.73725699 |
| 25 | Huntingtons disease_Homo sapiens_hsa05016 | 1.65117374 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.60605427 |
| 27 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.58640096 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.51333087 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.43607194 |
| 30 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.39689818 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.38802619 |
| 32 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.35837139 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.34890824 |
| 34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33561869 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.33192293 |
| 36 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.30227628 |
| 37 | Alzheimers disease_Homo sapiens_hsa05010 | 1.20874015 |
| 38 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18462113 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.17310881 |
| 40 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.13024242 |
| 41 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.11270816 |
| 42 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.09979130 |
| 43 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.07626524 |
| 44 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.04018636 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 1.02555665 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.96886200 |
| 47 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.96258007 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 0.96159067 |
| 49 | Base excision repair_Homo sapiens_hsa03410 | 0.94695471 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93850885 |
| 51 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.87998646 |
| 52 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.86681042 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.82161504 |
| 54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.81648696 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80430533 |
| 56 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.79797324 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78598162 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.75675348 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.74238018 |
| 60 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.72783763 |
| 61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.68759105 |
| 62 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.63705218 |
| 63 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.63482667 |
| 64 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.62852095 |
| 65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.62040854 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60370869 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.57877867 |
| 68 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.57121833 |
| 69 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.56981175 |
| 70 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.56942026 |
| 71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.55858162 |
| 72 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.54558742 |
| 73 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54027183 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.53097879 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.52670333 |
| 76 | Cell cycle_Homo sapiens_hsa04110 | 0.51345577 |
| 77 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.49579960 |
| 78 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.48702441 |
| 79 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.48557987 |
| 80 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.46622139 |
| 81 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.46157296 |
| 82 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.44631282 |
| 83 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44547744 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43913313 |
| 85 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.43288504 |
| 86 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41013880 |
| 87 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.40609752 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.40150154 |
| 89 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.39418815 |
| 90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.38770014 |
| 91 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.38480476 |
| 92 | Measles_Homo sapiens_hsa05162 | 0.38058828 |
| 93 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.37054317 |
| 94 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.33545571 |
| 95 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.31741586 |
| 96 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.29663965 |
| 97 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.29431498 |
| 98 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29026327 |
| 99 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26155974 |
| 100 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.24612463 |

