ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	immunoglobulin mediated immune response (GO:0016064)	6.44051073
2	positive thymic T cell selection (GO:0045059)	5.78275174
3	B cell mediated immunity (GO:0019724)	5.53631898
4	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.29578535
5	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.97785668
6	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.77170200
7	positive T cell selection (GO:0043368)	4.76547559
8	preassembly of GPI anchor in ER membrane (GO:0016254)	4.05806014
9	maturation of 5.8S rRNA (GO:0000460)	3.85254265
10	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.81104765
11	interferon-gamma-mediated signaling pathway (GO:0060333)	3.70958142
12	B cell receptor signaling pathway (GO:0050853)	3.67081672
13	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.49780546
14	positive regulation of protein homodimerization activity (GO:0090073)	3.49424841
15	regulation of DNA endoreduplication (GO:0032875)	3.46450454
16	regulation of germinal center formation (GO:0002634)	3.46285736
17	DNA deamination (GO:0045006)	3.35515335
18	cellular response to exogenous dsRNA (GO:0071360)	3.25363210
19	regulation of antigen processing and presentation (GO:0002577)	3.24508568
20	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	3.24329636
21	response to interferon-beta (GO:0035456)	3.14287210
22	GPI anchor biosynthetic process (GO:0006506)	3.13995378
23	negative regulation of granulocyte differentiation (GO:0030853)	3.11462353
24	cellular response to interferon-gamma (GO:0071346)	3.05995180
25	DNA catabolic process, exonucleolytic (GO:0000738)	3.05565573
26	positive regulation of cell cycle G1/S phase transition (GO:1902808)	3.04312933
27	negative regulation of telomere maintenance (GO:0032205)	3.04116427
28	negative regulation of thymocyte apoptotic process (GO:0070244)	3.03318320
29	regulation of alpha-beta T cell proliferation (GO:0046640)	2.97775243
30	L-fucose catabolic process (GO:0042355)	2.94738548
31	fucose catabolic process (GO:0019317)	2.94738548
32	L-fucose metabolic process (GO:0042354)	2.94738548
33	thymic T cell selection (GO:0045061)	2.94070635
34	GPI anchor metabolic process (GO:0006505)	2.93808468
35	regulation of oxidative stress-induced neuron death (GO:1903203)	2.92350513
36	replicative senescence (GO:0090399)	2.90908223
37	cellular response to interferon-beta (GO:0035458)	2.90781583
38	regulation of B cell apoptotic process (GO:0002902)	2.90404014
39	regulation of mitotic spindle checkpoint (GO:1903504)	2.88419315
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.88419315
41	antigen receptor-mediated signaling pathway (GO:0050851)	2.87379360
42	regulation of B cell receptor signaling pathway (GO:0050855)	2.83394063
43	positive regulation of vesicle fusion (GO:0031340)	2.81750988
44	response to hydroperoxide (GO:0033194)	2.80656282
45	aldehyde catabolic process (GO:0046185)	2.77961014
46	negative regulation of B cell proliferation (GO:0030889)	2.77841859
47	base-excision repair, AP site formation (GO:0006285)	2.77247919
48	lymphocyte costimulation (GO:0031294)	2.77024593
49	T cell costimulation (GO:0031295)	2.76738105
50	DNA double-strand break processing (GO:0000729)	2.76074929
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76019755
52	ribosome assembly (GO:0042255)	2.75799584
53	T cell selection (GO:0045058)	2.75633666
54	germinal center formation (GO:0002467)	2.74652340
55	negative regulation of B cell apoptotic process (GO:0002903)	2.73798540
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70780532
57	organelle disassembly (GO:1903008)	2.67503861
58	response to interferon-gamma (GO:0034341)	2.66394551
59	platelet dense granule organization (GO:0060155)	2.66222054
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66164887
61	regulation of thymocyte apoptotic process (GO:0070243)	2.66085499
62	deoxyribonucleotide catabolic process (GO:0009264)	2.64261300
63	deoxyribose phosphate catabolic process (GO:0046386)	2.61703731
64	adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli	2.60886321
65	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.59158106
66	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.59158106
67	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.59158106
68	positive regulation of antigen processing and presentation (GO:0002579)	2.57951222
69	ribonucleoprotein complex disassembly (GO:0032988)	2.57143275
70	indole-containing compound catabolic process (GO:0042436)	2.56304099
71	indolalkylamine catabolic process (GO:0046218)	2.56304099
72	tryptophan catabolic process (GO:0006569)	2.56304099
73	regulation of B cell proliferation (GO:0030888)	2.56150133
74	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.54471731
75	cellular response to ethanol (GO:0071361)	2.51580268
76	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.47705862
77	isotype switching (GO:0045190)	2.47705862
78	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.47705862
79	B cell activation (GO:0042113)	2.46775087
80	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.46352007
81	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.46352007
82	pseudouridine synthesis (GO:0001522)	2.44971074
83	C-terminal protein lipidation (GO:0006501)	2.44375638
84	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.44362799
85	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.43445845
86	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.43445845
87	regulation of granulocyte differentiation (GO:0030852)	2.40814642
88	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.39734042
89	ATP synthesis coupled proton transport (GO:0015986)	2.39734042
90	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.39675912
91	defense response to protozoan (GO:0042832)	2.38497780
92	B cell proliferation (GO:0042100)	2.38360501
93	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.37722364
94	response to lipoprotein particle (GO:0055094)	2.35429278
95	negative regulation of mast cell activation (GO:0033004)	2.35368077
96	cytidine deamination (GO:0009972)	2.35298331
97	cytidine metabolic process (GO:0046087)	2.35298331
98	cytidine catabolic process (GO:0006216)	2.35298331
99	B cell differentiation (GO:0030183)	2.34366029
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.33635070

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	6.31211807
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.01719429
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.98068080
4	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.96587707
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87562892
6	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.78963946
7	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.78877195
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.73626940
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.68545301
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60834004
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35922438
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30488608
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.22658984
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.20394769
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.14417481
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.10466961
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.00969075
18	GATA3_26560356_Chip-Seq_TH2_Human	1.97256140
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.96004243
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.95779539
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92710583
22	CIITA_25753668_ChIP-Seq_RAJI_Human	1.80171185
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79226610
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79135697
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78996258
26	EWS_26573619_Chip-Seq_HEK293_Human	1.76500199
27	MYB_26560356_Chip-Seq_TH2_Human	1.71956602
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67545290
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.63284823
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61992002
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61921324
32	SPI1_23547873_ChIP-Seq_NB4_Human	1.59863528
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58873798
34	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.56496549
35	VDR_22108803_ChIP-Seq_LS180_Human	1.55666850
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54997552
37	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.51191599
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50333108
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49053613
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46815396
41	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.44022607
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43825690
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.43207480
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41954100
45	P300_19829295_ChIP-Seq_ESCs_Human	1.41137931
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41013674
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39689918
48	GATA3_27048872_Chip-Seq_THYMUS_Human	1.39184771
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36641933
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36641933
51	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.34681606
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.34659133
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30123958
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29181252
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29181252
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27891764
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25860329
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25403561
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23021962
60	FUS_26573619_Chip-Seq_HEK293_Human	1.22818451
61	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21261674
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19816523
63	GATA3_26560356_Chip-Seq_TH1_Human	1.19489711
64	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18343089
65	AR_20517297_ChIP-Seq_VCAP_Human	1.18201873
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17961374
67	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16536459
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.12679881
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12416403
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.12051107
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.09937509
72	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.08831627
73	MYB_26560356_Chip-Seq_TH1_Human	1.08066266
74	TAF15_26573619_Chip-Seq_HEK293_Human	1.07903415
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07651517
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06892178
77	EGR1_19032775_ChIP-ChIP_M12_Human	1.06366665
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05820410
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05759815
80	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.04995323
81	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03497417
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02926412
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02187084
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98685346
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98414617
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98357236
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98282912
88	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.97431735
89	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.96480847
90	NCOR_22424771_ChIP-Seq_293T_Human	0.95854092
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95505192
92	GBX2_23144817_ChIP-Seq_PC3_Human	0.94764828
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94290691
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93948236
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93473965
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92964757
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92181313
98	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.91744572
99	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90761137
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90754611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.97054487
2	MP0005671_abnormal_response_to	3.70947471
3	MP0000685_abnormal_immune_system	3.32387118
4	MP0002166_altered_tumor_susceptibility	3.13028633
5	MP0001800_abnormal_humoral_immune	2.93322274
6	MP0001790_abnormal_immune_system	2.82560045
7	MP0005387_immune_system_phenotype	2.82560045
8	MP0002138_abnormal_hepatobiliary_system	2.62377868
9	MP0002006_tumorigenesis	2.52659473
10	MP0002837_dystrophic_cardiac_calcinosis	2.46595843
11	MP0002148_abnormal_hypersensitivity_rea	2.43563230
12	MP0009785_altered_susceptibility_to	2.36185927
13	MP0004147_increased_porphyrin_level	2.20006471
14	MP0005000_abnormal_immune_tolerance	2.19821144
15	MP0002452_abnormal_antigen_presenting	2.19263053
16	MP0002723_abnormal_immune_serum	2.11676963
17	MP0003195_calcinosis	2.00343993
18	MP0008058_abnormal_DNA_repair	1.98446435
19	MP0002420_abnormal_adaptive_immunity	1.95250868
20	MP0002009_preneoplasia	1.94474495
21	MP0001819_abnormal_immune_cell	1.93496358
22	MP0003806_abnormal_nucleotide_metabolis	1.86110732
23	MP0000569_abnormal_digit_pigmentation	1.84670783
24	MP0005075_abnormal_melanosome_morpholog	1.80452610
25	MP0010155_abnormal_intestine_physiology	1.79560596
26	MP0002398_abnormal_bone_marrow	1.77212896
27	MP0000689_abnormal_spleen_morphology	1.70757006
28	MP0005220_abnormal_exocrine_pancreas	1.67649789
29	MP0003763_abnormal_thymus_physiology	1.65444711
30	MP0000716_abnormal_immune_system	1.65335970
31	MP0008877_abnormal_DNA_methylation	1.61365690
32	MP0001986_abnormal_taste_sensitivity	1.58799543
33	MP0002419_abnormal_innate_immunity	1.58533681
34	MP0005464_abnormal_platelet_physiology	1.58174920
35	MP0000015_abnormal_ear_pigmentation	1.58172636
36	MP0008875_abnormal_xenobiotic_pharmacok	1.55644430
37	MP0008872_abnormal_physiological_respon	1.54307058
38	MP0005025_abnormal_response_to	1.51867476
39	MP0008057_abnormal_DNA_replication	1.47922034
40	MP0005174_abnormal_tail_pigmentation	1.47121043
41	MP0006072_abnormal_retinal_apoptosis	1.45244341
42	MP0003724_increased_susceptibility_to	1.42058385
43	MP0009764_decreased_sensitivity_to	1.40506151
44	MP0002722_abnormal_immune_system	1.38655828
45	MP0001873_stomach_inflammation	1.35544347
46	MP0010094_abnormal_chromosome_stability	1.32829444
47	MP0001853_heart_inflammation	1.32678033
48	MP0002429_abnormal_blood_cell	1.32529318
49	MP0004084_abnormal_cardiac_muscle	1.31695341
50	MP0002405_respiratory_system_inflammati	1.31135435
51	MP0005085_abnormal_gallbladder_physiolo	1.27305186
52	MP0004947_skin_inflammation	1.18631056
53	MP0000703_abnormal_thymus_morphology	1.17549310
54	MP0001845_abnormal_inflammatory_respons	1.17284763
55	MP0009333_abnormal_splenocyte_physiolog	1.15509747
56	MP0005084_abnormal_gallbladder_morpholo	1.13084230
57	MP0003646_muscle_fatigue	1.12136711
58	MP0002102_abnormal_ear_morphology	1.11155864
59	MP0000490_abnormal_crypts_of	1.08400159
60	MP0002095_abnormal_skin_pigmentation	1.06352181
61	MP0006036_abnormal_mitochondrial_physio	1.03533653
62	MP0008469_abnormal_protein_level	1.02530050
63	MP0003183_abnormal_peptide_metabolism	0.97502949
64	MP0002019_abnormal_tumor_incidence	0.93922312
65	MP0003111_abnormal_nucleus_morphology	0.92191519
66	MP0003045_fibrosis	0.90076662
67	MP0005360_urolithiasis	0.87414006
68	MP0003436_decreased_susceptibility_to	0.85122376
69	MP0001764_abnormal_homeostasis	0.84682359
70	MP0002653_abnormal_ependyma_morphology	0.83501773
71	MP0000372_irregular_coat_pigmentation	0.83440687
72	MP0002139_abnormal_hepatobiliary_system	0.82047876
73	MP0003866_abnormal_defecation	0.80144980
74	MP0004145_abnormal_muscle_electrophysio	0.79765888
75	MP0005167_abnormal_blood-brain_barrier	0.78874277
76	MP0004808_abnormal_hematopoietic_stem	0.77534656
77	MP0004142_abnormal_muscle_tone	0.76764325
78	MP0003786_premature_aging	0.75807426
79	MP0003136_yellow_coat_color	0.73992617
80	MP0002396_abnormal_hematopoietic_system	0.72569906
81	MP0002693_abnormal_pancreas_physiology	0.71223993
82	MP0003075_altered_response_to	0.70824599
83	MP0002876_abnormal_thyroid_physiology	0.70693663
84	MP0004782_abnormal_surfactant_physiolog	0.70519822
85	MP0005166_decreased_susceptibility_to	0.69430883
86	MP0008007_abnormal_cellular_replicative	0.68243270
87	MP0001661_extended_life_span	0.67643102
88	MP0005646_abnormal_pituitary_gland	0.67596780
89	MP0003252_abnormal_bile_duct	0.67276238
90	MP0006082_CNS_inflammation	0.66905955
91	MP0008775_abnormal_heart_ventricle	0.66106190
92	MP0005319_abnormal_enzyme/_coenzyme	0.66048210
93	MP0000470_abnormal_stomach_morphology	0.64914622
94	MP0003718_maternal_effect	0.64753643
95	MP0005551_abnormal_eye_electrophysiolog	0.64411053
96	MP0002075_abnormal_coat/hair_pigmentati	0.63981413
97	MP0005645_abnormal_hypothalamus_physiol	0.62917562
98	MP0001968_abnormal_touch/_nociception	0.60928751
99	MP0000230_abnormal_systemic_arterial	0.60321844
100	MP0010368_abnormal_lymphatic_system	0.60177752

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	5.16952507
2	Abnormality of B cell number (HP:0010975)	5.10229513
3	Panhypogammaglobulinemia (HP:0003139)	4.43856084
4	Stomach cancer (HP:0012126)	4.14734694
5	B lymphocytopenia (HP:0010976)	3.73011940
6	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.53957946
7	Congenital, generalized hypertrichosis (HP:0004540)	3.53930322
8	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.51215161
9	Abnormality of the prostate (HP:0008775)	3.43694754
10	Meningitis (HP:0001287)	3.20848518
11	Chronic sinusitis (HP:0011109)	3.15869082
12	Recurrent fungal infections (HP:0002841)	3.06768630
13	3-Methylglutaconic aciduria (HP:0003535)	3.04252125
14	IgG deficiency (HP:0004315)	3.02495999
15	Thyroiditis (HP:0100646)	2.98580124
16	Elevated erythrocyte sedimentation rate (HP:0003565)	2.96032140
17	Eosinophilia (HP:0001880)	2.91561283
18	Amelogenesis imperfecta (HP:0000705)	2.86786826
19	Autoimmune thrombocytopenia (HP:0001973)	2.84711218
20	Hypoproteinemia (HP:0003075)	2.84343664
21	Abnormality of T cell number (HP:0011839)	2.82987593
22	Chronic mucocutaneous candidiasis (HP:0002728)	2.76689986
23	Recurrent cutaneous fungal infections (HP:0011370)	2.76689986
24	Severe combined immunodeficiency (HP:0004430)	2.72310555
25	Parakeratosis (HP:0001036)	2.71380279
26	Abnormality of the renal cortex (HP:0011035)	2.70268654
27	Autoimmune hemolytic anemia (HP:0001890)	2.68865277
28	Abnormality of T cell physiology (HP:0011840)	2.66390484
29	Abnormality of T cells (HP:0002843)	2.60970306
30	Increased IgM level (HP:0003496)	2.58917356
31	Hematochezia (HP:0002573)	2.58674601
32	Renal cortical cysts (HP:0000803)	2.58083218
33	Lipid accumulation in hepatocytes (HP:0006561)	2.50842976
34	Hypoplasia of the thymus (HP:0000778)	2.49218100
35	Increased CSF lactate (HP:0002490)	2.47752826
36	Supernumerary spleens (HP:0009799)	2.44481931
37	Mitochondrial inheritance (HP:0001427)	2.43912990
38	Hemoptysis (HP:0002105)	2.43650614
39	Increased hepatocellular lipid droplets (HP:0006565)	2.40929277
40	Abnormality of eosinophils (HP:0001879)	2.38698869
41	Fair hair (HP:0002286)	2.37454637
42	Pancreatic cysts (HP:0001737)	2.36779015
43	Bile duct proliferation (HP:0001408)	2.36721153
44	Abnormal biliary tract physiology (HP:0012439)	2.36721153
45	Acute necrotizing encephalopathy (HP:0006965)	2.33967165
46	Delayed CNS myelination (HP:0002188)	2.31098147
47	Hepatic necrosis (HP:0002605)	2.30790022
48	Recurrent viral infections (HP:0004429)	2.30656357
49	T lymphocytopenia (HP:0005403)	2.30498525
50	Hyperphosphatemia (HP:0002905)	2.29109743
51	Chronic diarrhea (HP:0002028)	2.28662961
52	Granulocytopenia (HP:0001913)	2.23661896
53	Verrucae (HP:0200043)	2.23562496
54	Papilloma (HP:0012740)	2.23562496
55	Vasculitis (HP:0002633)	2.20718610
56	Hepatocellular necrosis (HP:0001404)	2.20573268
57	Dry hair (HP:0011359)	2.19391288
58	Progressive macrocephaly (HP:0004481)	2.17368934
59	Pulmonary infiltrates (HP:0002113)	2.16878455
60	Acute encephalopathy (HP:0006846)	2.13839461
61	Combined immunodeficiency (HP:0005387)	2.13407154
62	Stomatitis (HP:0010280)	2.10979201
63	Abnormal mitochondria in muscle tissue (HP:0008316)	2.08010381
64	Cheilitis (HP:0100825)	2.07403597
65	Neoplasm of the adrenal cortex (HP:0100641)	2.06119338
66	Congenital stationary night blindness (HP:0007642)	2.03370676
67	Recurrent bronchitis (HP:0002837)	2.02733103
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00240692
69	Inflammation of the large intestine (HP:0002037)	1.99862815
70	Prostate neoplasm (HP:0100787)	1.99582377
71	Exertional dyspnea (HP:0002875)	1.99451662
72	Progressive microcephaly (HP:0000253)	1.98692399
73	Abnormality of male internal genitalia (HP:0000022)	1.98634771
74	Methylmalonic acidemia (HP:0002912)	1.98473406
75	Asplenia (HP:0001746)	1.97740084
76	Short chin (HP:0000331)	1.97729852
77	Pustule (HP:0200039)	1.96076108
78	Increased serum lactate (HP:0002151)	1.95278427
79	Abnormality of dental color (HP:0011073)	1.93790524
80	Skin rash (HP:0000988)	1.93688556
81	Polydipsia (HP:0001959)	1.92153890
82	Abnormal drinking behavior (HP:0030082)	1.92153890
83	Abnormality of the pleura (HP:0002103)	1.92054972
84	Abnormality of the axillary hair (HP:0100134)	1.90083849
85	Abnormality of secondary sexual hair (HP:0009888)	1.90083849
86	Encephalitis (HP:0002383)	1.88948385
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86296628
88	Absent/shortened dynein arms (HP:0200106)	1.86296628
89	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.85186652
90	Hyperventilation (HP:0002883)	1.84778107
91	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.84478822
92	Neutropenia (HP:0001875)	1.83592227
93	Erythroderma (HP:0001019)	1.83583670
94	Generalized hypopigmentation of hair (HP:0011358)	1.83567735
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.82310853
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81821967
97	Increased intramyocellular lipid droplets (HP:0012240)	1.81397970
98	Pancreatic fibrosis (HP:0100732)	1.80326080
99	Constricted visual fields (HP:0001133)	1.79925748
100	Retrobulbar optic neuritis (HP:0100654)	1.79720520

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K10	5.93867549
2	BMPR1B	3.61143348
3	ZAK	3.30406323
4	STK16	3.04080238
5	TEC	2.85217510
6	FRK	2.76755360
7	TLK1	2.74289137
8	EIF2AK3	2.44616507
9	TAOK3	2.31008273
10	BMPR2	2.12904741
11	ITK	2.09719908
12	KIT	2.09425943
13	MST4	2.05778033
14	DAPK2	1.93746367
15	ADRBK2	1.91664683
16	PLK2	1.89644082
17	CDK8	1.82360153
18	RIPK4	1.74528146
19	TGFBR1	1.73591026
20	MAP3K14	1.71328746
21	NUAK1	1.68361091
22	BTK	1.59003918
23	MAP4K1	1.57012330
24	GRK1	1.49659363
25	SYK	1.48260407
26	DAPK1	1.37890850
27	VRK2	1.35424929
28	TXK	1.32097579
29	STK38L	1.29138569
30	EIF2AK1	1.26273807
31	CSF1R	1.21009878
32	MAP4K2	1.19619797
33	IKBKB	1.13869891
34	TAF1	1.11839318
35	WNK4	1.05297912
36	MAP2K2	1.05207132
37	VRK1	1.04813273
38	MKNK2	1.03414507
39	EIF2AK2	1.01174420
40	MKNK1	1.01032481
41	PLK3	1.00495883
42	FLT3	0.97619814
43	LYN	0.85830569
44	MAP3K12	0.84436904
45	STK24	0.81059329
46	CDK19	0.77573018
47	STK38	0.77303783
48	HCK	0.71037720
49	WNK3	0.68549528
50	FES	0.67697303
51	TSSK6	0.67604296
52	LCK	0.65220474
53	OXSR1	0.65196808
54	CSNK1G3	0.63489553
55	CSNK1G1	0.61975284
56	MAPKAPK3	0.61074001
57	MAP3K13	0.61015460
58	IGF1R	0.60846353
59	ERBB3	0.60280680
60	CSNK1A1L	0.60123015
61	DAPK3	0.57741363
62	CCNB1	0.57598058
63	CDK6	0.57573050
64	YES1	0.57058162
65	PIK3CG	0.57024963
66	BUB1	0.56407683
67	BLK	0.55412422
68	RPS6KA4	0.54845692
69	AKT3	0.54730682
70	PRKCI	0.53848906
71	KDR	0.52644181
72	CDK9	0.45969878
73	BCKDK	0.45482947
74	ATR	0.44356742
75	JAK3	0.43555495
76	GRK7	0.42711391
77	PRKCQ	0.42372676
78	PRKCE	0.42289978
79	TRPM7	0.41770558
80	PIM1	0.40625327
81	ABL1	0.40453999
82	ACVR1B	0.40182323
83	HIPK2	0.38946849
84	INSRR	0.38423939
85	GRK6	0.36858971
86	MAPK7	0.35979181
87	CHUK	0.35856560
88	CSNK1G2	0.34081778
89	MAPK13	0.34072900
90	PLK4	0.33016353
91	BRAF	0.32294988
92	SRPK1	0.32125443
93	IKBKE	0.31268464
94	STK3	0.30272410
95	GRK5	0.29608867
96	CDK4	0.29296995
97	MAPKAPK5	0.29166038
98	TRIM28	0.29034225
99	ADRBK1	0.27569303
100	CSK	0.27503765

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	6.04550088
2	Allograft rejection_Homo sapiens_hsa05330	4.91676904
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.68209551
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.46546665
5	Graft-versus-host disease_Homo sapiens_hsa05332	4.32430127
6	Type I diabetes mellitus_Homo sapiens_hsa04940	4.02888875
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.68222205
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.55326773
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.48869793
10	Viral myocarditis_Homo sapiens_hsa05416	2.43928095
11	Proteasome_Homo sapiens_hsa03050	2.30638101
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.24188281
13	Rheumatoid arthritis_Homo sapiens_hsa05323	2.09840650
14	Leishmaniasis_Homo sapiens_hsa05140	2.03586861
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65139139
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47450540
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43421330
18	Protein export_Homo sapiens_hsa03060	1.27239164
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.23039603
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22078711
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21588149
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.19936748
23	RNA polymerase_Homo sapiens_hsa03020	1.08171912
24	Toxoplasmosis_Homo sapiens_hsa05145	1.03502647
25	RNA degradation_Homo sapiens_hsa03018	1.00539618
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99618716
27	Non-homologous end-joining_Homo sapiens_hsa03450	0.99283189
28	Herpes simplex infection_Homo sapiens_hsa05168	0.97766668
29	Parkinsons disease_Homo sapiens_hsa05012	0.97740952
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97264418
31	Tuberculosis_Homo sapiens_hsa05152	0.93183695
32	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92411658
33	Homologous recombination_Homo sapiens_hsa03440	0.89098370
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81982489
35	Caffeine metabolism_Homo sapiens_hsa00232	0.78183550
36	Retinol metabolism_Homo sapiens_hsa00830	0.76146637
37	Influenza A_Homo sapiens_hsa05164	0.73712695
38	Sulfur metabolism_Homo sapiens_hsa00920	0.73691239
39	Peroxisome_Homo sapiens_hsa04146	0.72851248
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72288495
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71192536
42	Base excision repair_Homo sapiens_hsa03410	0.69200624
43	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68352393
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65501234
45	One carbon pool by folate_Homo sapiens_hsa00670	0.64157343
46	Ribosome_Homo sapiens_hsa03010	0.62878981
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62599105
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.59755022
49	Propanoate metabolism_Homo sapiens_hsa00640	0.57662102
50	Mismatch repair_Homo sapiens_hsa03430	0.57372749
51	Phagosome_Homo sapiens_hsa04145	0.56948190
52	Legionellosis_Homo sapiens_hsa05134	0.54921590
53	Phototransduction_Homo sapiens_hsa04744	0.54245239
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54053870
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53332923
56	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.52129162
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.50821552
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50518669
59	Spliceosome_Homo sapiens_hsa03040	0.48827178
60	Alzheimers disease_Homo sapiens_hsa05010	0.46936584
61	Regulation of autophagy_Homo sapiens_hsa04140	0.46066610
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45764117
63	Purine metabolism_Homo sapiens_hsa00230	0.44920560
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.43999082
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43000799
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.41724155
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41099231
68	Huntingtons disease_Homo sapiens_hsa05016	0.41079351
69	RNA transport_Homo sapiens_hsa03013	0.40932241
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39824326
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.38164297
72	p53 signaling pathway_Homo sapiens_hsa04115	0.38081065
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.36214678
74	Basal transcription factors_Homo sapiens_hsa03022	0.36076261
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33857129
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.31885619
77	DNA replication_Homo sapiens_hsa03030	0.31883607
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29648603
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29613966
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28701907
81	Pertussis_Homo sapiens_hsa05133	0.28436691
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.27747558
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27489565
84	Measles_Homo sapiens_hsa05162	0.26679784
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26587447
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25592508
87	HTLV-I infection_Homo sapiens_hsa05166	0.25557046
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24158807
89	Fatty acid degradation_Homo sapiens_hsa00071	0.23554365
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.22045231
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.21330745
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.20499781
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.20181273
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19285475
95	Taste transduction_Homo sapiens_hsa04742	0.17327115
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.16678604
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.15274494
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.15209851
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.14582055
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.08843599

NPM1P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »