ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.43822334
2	maturation of 5.8S rRNA (GO:0000460)	4.40619433
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.36480366
4	proteasome assembly (GO:0043248)	4.35656787
5	regulation of centriole replication (GO:0046599)	4.22832516
6	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.21586581
7	regulation of chronic inflammatory response (GO:0002676)	3.92706486
8	DNA deamination (GO:0045006)	3.92077507
9	regulation of isotype switching to IgG isotypes (GO:0048302)	3.77082983
10	rRNA modification (GO:0000154)	3.63684344
11	ribosome assembly (GO:0042255)	3.63454095
12	rRNA catabolic process (GO:0016075)	3.61977571
13	protein polyglutamylation (GO:0018095)	3.56360441
14	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.53793626
15	nuclear pore complex assembly (GO:0051292)	3.48558582
16	pseudouridine synthesis (GO:0001522)	3.37103782
17	nuclear pore organization (GO:0006999)	3.33486964
18	regulation of immunoglobulin secretion (GO:0051023)	3.32513669
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.30664589
20	neural tube formation (GO:0001841)	3.29962665
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.17872676
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16374790
23	ribosomal large subunit biogenesis (GO:0042273)	3.13967550
24	rRNA methylation (GO:0031167)	3.11246990
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09759002
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09759002
27	NADH dehydrogenase complex assembly (GO:0010257)	3.09759002
28	double-strand break repair via homologous recombination (GO:0000724)	3.07625134
29	positive regulation of isotype switching (GO:0045830)	3.04845564
30	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.03904634
31	isotype switching (GO:0045190)	3.03904634
32	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.03904634
33	termination of RNA polymerase III transcription (GO:0006386)	3.03184920
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03184920
35	recombinational repair (GO:0000725)	3.02277132
36	rRNA processing (GO:0006364)	2.98538414
37	monoubiquitinated protein deubiquitination (GO:0035520)	2.98334699
38	protein K11-linked deubiquitination (GO:0035871)	2.98133046
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96126821
40	DNA demethylation (GO:0080111)	2.94528138
41	GTP biosynthetic process (GO:0006183)	2.94217143
42	rRNA metabolic process (GO:0016072)	2.92714308
43	cullin deneddylation (GO:0010388)	2.92272039
44	positive regulation of granulocyte differentiation (GO:0030854)	2.90240829
45	embryonic hemopoiesis (GO:0035162)	2.90103190
46	CENP-A containing nucleosome assembly (GO:0034080)	2.88396507
47	chromatin remodeling at centromere (GO:0031055)	2.87262011
48	intracellular protein transmembrane import (GO:0044743)	2.86728084
49	histone mRNA metabolic process (GO:0008334)	2.86218571
50	regulation of regulatory T cell differentiation (GO:0045589)	2.85906918
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.85796387
52	transcription from mitochondrial promoter (GO:0006390)	2.84462519
53	positive regulation of DNA recombination (GO:0045911)	2.83942692
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82619376
55	histone mRNA catabolic process (GO:0071044)	2.81622124
56	spliceosomal complex assembly (GO:0000245)	2.79986224
57	DNA-dependent DNA replication (GO:0006261)	2.79499453
58	keratinocyte development (GO:0003334)	2.77474515
59	mitochondrial RNA metabolic process (GO:0000959)	2.76832943
60	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.76604222
61	regulation of DNA endoreduplication (GO:0032875)	2.74308343
62	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.74161238
63	UTP biosynthetic process (GO:0006228)	2.72773707
64	regulation of centrosome duplication (GO:0010824)	2.71599237
65	spliceosomal snRNP assembly (GO:0000387)	2.67394604
66	alpha-beta T cell differentiation (GO:0046632)	2.66843405
67	termination of RNA polymerase I transcription (GO:0006363)	2.65202890
68	DNA replication checkpoint (GO:0000076)	2.64920303
69	telomere maintenance via telomerase (GO:0007004)	2.62932574
70	definitive hemopoiesis (GO:0060216)	2.62754121
71	ribosome biogenesis (GO:0042254)	2.62461421
72	protein K63-linked deubiquitination (GO:0070536)	2.61659801
73	estrogen biosynthetic process (GO:0006703)	2.58441665
74	pore complex assembly (GO:0046931)	2.58318884
75	UTP metabolic process (GO:0046051)	2.57605148
76	behavioral response to nicotine (GO:0035095)	2.57495808
77	tRNA processing (GO:0008033)	2.56023543
78	histone exchange (GO:0043486)	2.55902129
79	DNA dealkylation (GO:0035510)	2.55193427
80	ncRNA catabolic process (GO:0034661)	2.54711839
81	ribonucleoprotein complex biogenesis (GO:0022613)	2.53577386
82	organelle disassembly (GO:1903008)	2.53036796
83	protein deneddylation (GO:0000338)	2.52376639
84	ncRNA metabolic process (GO:0034660)	2.51420690
85	regulation of centrosome cycle (GO:0046605)	2.51098919
86	negative regulation of T-helper cell differentiation (GO:0045623)	2.50698372
87	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.50698372
88	tRNA metabolic process (GO:0006399)	2.49479540
89	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.48250231
90	viral mRNA export from host cell nucleus (GO:0046784)	2.47422595
91	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.46116813
92	T-helper cell differentiation (GO:0042093)	2.45338348
93	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.45338348
94	IMP metabolic process (GO:0046040)	2.44944493
95	protein complex biogenesis (GO:0070271)	2.44583963
96	ncRNA processing (GO:0034470)	2.44315939
97	protein prenylation (GO:0018342)	2.44273533
98	prenylation (GO:0097354)	2.44273533
99	CD4-positive, alpha-beta T cell differentiation (GO:0043367)	2.44042670
100	replicative senescence (GO:0090399)	2.43827204

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.59082942
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.79084818
3	VDR_22108803_ChIP-Seq_LS180_Human	3.38628644
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32329266
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.16879965
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.04984798
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.63517374
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58422738
9	EWS_26573619_Chip-Seq_HEK293_Human	2.55418285
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.55093211
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.48242077
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41327570
13	GATA1_22025678_ChIP-Seq_K562_Human	2.41276694
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.38469671
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.36459479
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.28939379
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18076980
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.16102201
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.08576492
20	FUS_26573619_Chip-Seq_HEK293_Human	2.01794600
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96180769
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.95866327
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.93032852
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92329658
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91691986
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.87807185
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83965296
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82273120
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80397187
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.77101351
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74854227
32	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.73914532
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71820938
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.70395604
35	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.70045115
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65596377
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65214585
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.63528338
39	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61206684
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52878679
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.49644807
42	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.48331181
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.47044760
44	P300_19829295_ChIP-Seq_ESCs_Human	1.46512237
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36480777
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34334643
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33835117
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32753785
49	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31809024
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24613538
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23638966
52	GATA3_26560356_Chip-Seq_TH2_Human	1.21355504
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.20784019
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20490939
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18062839
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.16553221
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16553221
58	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15792897
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14337230
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14226960
61	GBX2_23144817_ChIP-Seq_PC3_Human	1.14166689
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14109929
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11550913
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11357780
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11213795
66	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.09571855
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08434090
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.07994185
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07533091
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07127024
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05838298
72	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04436795
73	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.04047066
74	P300_18555785_Chip-Seq_ESCs_Mouse	1.03978830
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03783089
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00814227
77	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00128991
78	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99894823
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99894823
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99821345
81	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98674756
82	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.97398990
83	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97258706
84	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.96782924
85	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96384368
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96222454
87	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95964932
88	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95430323
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94286453
90	STAT3_23295773_ChIP-Seq_U87_Human	0.93889116
91	GABP_19822575_ChIP-Seq_HepG2_Human	0.93827917
92	TCF4_23295773_ChIP-Seq_U87_Human	0.92130848
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92092372
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.91238306
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.90310711
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89612960
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.89597169
98	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.88720631
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.87786565
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.87770903

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.47850952
2	MP0000569_abnormal_digit_pigmentation	2.85955644
3	MP0003786_premature_aging	2.58631569
4	MP0010094_abnormal_chromosome_stability	2.46056336
5	MP0008058_abnormal_DNA_repair	2.39263629
6	MP0009697_abnormal_copulation	2.30271610
7	MP0001835_abnormal_antigen_presentation	2.27432136
8	MP0002009_preneoplasia	2.21615968
9	MP0005408_hypopigmentation	2.14846031
10	MP0005310_abnormal_salivary_gland	2.03813444
11	MP0004957_abnormal_blastocyst_morpholog	2.02491218
12	MP0006035_abnormal_mitochondrial_morpho	1.96497382
13	MP0003763_abnormal_thymus_physiology	1.89855339
14	MP0008877_abnormal_DNA_methylation	1.89570129
15	MP0000685_abnormal_immune_system	1.83706539
16	MP0006072_abnormal_retinal_apoptosis	1.81755162
17	MP0003077_abnormal_cell_cycle	1.81718423
18	MP0003718_maternal_effect	1.75900087
19	MP0003221_abnormal_cardiomyocyte_apopto	1.75136428
20	MP0002837_dystrophic_cardiac_calcinosis	1.73558862
21	MP0008875_abnormal_xenobiotic_pharmacok	1.72006730
22	MP0004147_increased_porphyrin_level	1.71889230
23	MP0003693_abnormal_embryo_hatching	1.66538684
24	MP0003567_abnormal_fetal_cardiomyocyte	1.65059068
25	MP0003195_calcinosis	1.64281015
26	MP0002166_altered_tumor_susceptibility	1.61559809
27	MP0000465_gastrointestinal_hemorrhage	1.60026144
28	MP0001873_stomach_inflammation	1.56390133
29	MP0005646_abnormal_pituitary_gland	1.53719519
30	MP0005645_abnormal_hypothalamus_physiol	1.50965766
31	MP0002006_tumorigenesis	1.45605061
32	MP0004808_abnormal_hematopoietic_stem	1.45096283
33	MP0002102_abnormal_ear_morphology	1.43865162
34	MP0008995_early_reproductive_senescence	1.43802073
35	MP0000427_abnormal_hair_cycle	1.43728206
36	MP0002138_abnormal_hepatobiliary_system	1.43030213
37	MP0001529_abnormal_vocalization	1.41719255
38	MP0003045_fibrosis	1.37698602
39	MP0001853_heart_inflammation	1.37006188
40	MP0008007_abnormal_cellular_replicative	1.34477425
41	MP0005253_abnormal_eye_physiology	1.34010356
42	MP0008789_abnormal_olfactory_epithelium	1.30177042
43	MP0005551_abnormal_eye_electrophysiolog	1.27847002
44	MP0008872_abnormal_physiological_respon	1.27755289
45	MP0002396_abnormal_hematopoietic_system	1.27644878
46	MP0008961_abnormal_basal_metabolism	1.25668444
47	MP0001501_abnormal_sleep_pattern	1.25329106
48	MP0006276_abnormal_autonomic_nervous	1.23950296
49	MP0002928_abnormal_bile_duct	1.21053855
50	MP0004145_abnormal_muscle_electrophysio	1.20004354
51	MP0004142_abnormal_muscle_tone	1.16468992
52	MP0004782_abnormal_surfactant_physiolog	1.15288866
53	MP0005389_reproductive_system_phenotype	1.14790937
54	MP0003880_abnormal_central_pattern	1.11521145
55	MP0005075_abnormal_melanosome_morpholog	1.11387610
56	MP0004133_heterotaxia	1.10963116
57	MP0000383_abnormal_hair_follicle	1.10953441
58	MP0002398_abnormal_bone_marrow	1.07657261
59	MP0002638_abnormal_pupillary_reflex	1.05356668
60	MP0000703_abnormal_thymus_morphology	1.05030564
61	MP0001119_abnormal_female_reproductive	1.01740805
62	MP0003646_muscle_fatigue	0.99891142
63	MP0003186_abnormal_redox_activity	0.99865704
64	MP0002160_abnormal_reproductive_system	0.99431908
65	MP0003890_abnormal_embryonic-extraembry	0.98936873
66	MP0001800_abnormal_humoral_immune	0.96659986
67	MP0000371_diluted_coat_color	0.96046208
68	MP0000689_abnormal_spleen_morphology	0.95055146
69	MP0005387_immune_system_phenotype	0.93926192
70	MP0001790_abnormal_immune_system	0.93926192
71	MP0000631_abnormal_neuroendocrine_gland	0.92717321
72	MP0008932_abnormal_embryonic_tissue	0.90446629
73	MP0001919_abnormal_reproductive_system	0.88463509
74	MP0001697_abnormal_embryo_size	0.87117310
75	MP0006292_abnormal_olfactory_placode	0.85244654
76	MP0003111_abnormal_nucleus_morphology	0.84558907
77	MP0005379_endocrine/exocrine_gland_phen	0.83173659
78	MP0005395_other_phenotype	0.82860873
79	MP0002148_abnormal_hypersensitivity_rea	0.82619664
80	MP0002088_abnormal_embryonic_growth/wei	0.81416960
81	MP0003300_gastrointestinal_ulcer	0.80833339
82	MP0002210_abnormal_sex_determination	0.79515158
83	MP0002722_abnormal_immune_system	0.78933932
84	MP0000647_abnormal_sebaceous_gland	0.78604414
85	MP0003984_embryonic_growth_retardation	0.77038033
86	MP0005380_embryogenesis_phenotype	0.75845048
87	MP0001672_abnormal_embryogenesis/_devel	0.75845048
88	MP0005083_abnormal_biliary_tract	0.74971235
89	MP0005248_abnormal_Harderian_gland	0.74655684
90	MP0001968_abnormal_touch/_nociception	0.74155302
91	MP0004215_abnormal_myocardial_fiber	0.74103584
92	MP0005499_abnormal_olfactory_system	0.73588731
93	MP0005394_taste/olfaction_phenotype	0.73588731
94	MP0001929_abnormal_gametogenesis	0.72737964
95	MP0001666_abnormal_nutrient_absorption	0.72439566
96	MP0002736_abnormal_nociception_after	0.72347119
97	MP0000372_irregular_coat_pigmentation	0.71653472
98	MP0005187_abnormal_penis_morphology	0.71523346
99	MP0001293_anophthalmia	0.70619644
100	MP0000716_abnormal_immune_system	0.70240676

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dyschromatopsia (HP:0007641)	4.47887984
2	Stomatitis (HP:0010280)	3.87621016
3	Pancreatic cysts (HP:0001737)	2.95132160
4	Limb hypertonia (HP:0002509)	2.88528580
5	Abnormality of macular pigmentation (HP:0008002)	2.81896950
6	Increased hepatocellular lipid droplets (HP:0006565)	2.80213361
7	Abnormality of alanine metabolism (HP:0010916)	2.75689822
8	Hyperalaninemia (HP:0003348)	2.75689822
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.75689822
10	IgM deficiency (HP:0002850)	2.66269476
11	Clubbing of toes (HP:0100760)	2.63816121
12	Abnormality of the renal cortex (HP:0011035)	2.63635942
13	Abnormality of midbrain morphology (HP:0002418)	2.61292364
14	Molar tooth sign on MRI (HP:0002419)	2.61292364
15	Renal cortical cysts (HP:0000803)	2.59478380
16	Nephronophthisis (HP:0000090)	2.56871032
17	Abnormal biliary tract physiology (HP:0012439)	2.55964054
18	Bile duct proliferation (HP:0001408)	2.55964054
19	Increased CSF lactate (HP:0002490)	2.55012108
20	Abnormality of T cell physiology (HP:0011840)	2.48129969
21	Volvulus (HP:0002580)	2.47146128
22	Central scotoma (HP:0000603)	2.41123742
23	Abnormality of the renal medulla (HP:0100957)	2.38717936
24	Lipid accumulation in hepatocytes (HP:0006561)	2.34355669
25	Hyperglycinuria (HP:0003108)	2.29240118
26	Meckel diverticulum (HP:0002245)	2.27475570
27	IgG deficiency (HP:0004315)	2.26590561
28	Abnormality of the ileum (HP:0001549)	2.25451494
29	Acute necrotizing encephalopathy (HP:0006965)	2.25232880
30	IgA deficiency (HP:0002720)	2.23704037
31	Abnormality of the columella (HP:0009929)	2.23549429
32	Genetic anticipation (HP:0003743)	2.20817158
33	Pancreatic fibrosis (HP:0100732)	2.20690203
34	Acute encephalopathy (HP:0006846)	2.17229456
35	Reduced antithrombin III activity (HP:0001976)	2.16677706
36	Renal Fanconi syndrome (HP:0001994)	2.16556452
37	Poor head control (HP:0002421)	2.15756648
38	Colon cancer (HP:0003003)	2.14674739
39	Hyperglycinemia (HP:0002154)	2.12432955
40	Mitochondrial inheritance (HP:0001427)	2.12113217
41	Myelodysplasia (HP:0002863)	2.11018834
42	Abnormality of chromosome stability (HP:0003220)	2.10999773
43	Hypochromic microcytic anemia (HP:0004840)	2.10319138
44	Abolished electroretinogram (ERG) (HP:0000550)	2.09646800
45	B lymphocytopenia (HP:0010976)	2.09066015
46	Abnormality of B cell number (HP:0010975)	2.09037452
47	3-Methylglutaconic aciduria (HP:0003535)	2.08198528
48	Supernumerary spleens (HP:0009799)	2.07455446
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06511311
50	Increased serum lactate (HP:0002151)	2.06361880
51	Progressive macrocephaly (HP:0004481)	2.06115936
52	Autoimmune hemolytic anemia (HP:0001890)	2.04320833
53	Neoplasm of the adrenal cortex (HP:0100641)	2.03478622
54	Acute myeloid leukemia (HP:0004808)	2.03265848
55	Abnormality of the preputium (HP:0100587)	2.01537735
56	Capillary hemangiomas (HP:0005306)	2.01289754
57	Ectopic kidney (HP:0000086)	2.01199775
58	True hermaphroditism (HP:0010459)	2.00567620
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98509852
60	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97852528
61	Rhabdomyosarcoma (HP:0002859)	1.97811768
62	Abnormality of the labia minora (HP:0012880)	1.96883308
63	Medial flaring of the eyebrow (HP:0010747)	1.95887147
64	Abnormal rod and cone electroretinograms (HP:0008323)	1.93896332
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91710943
66	Stomach cancer (HP:0012126)	1.88531229
67	Thyroiditis (HP:0100646)	1.88311055
68	Birth length less than 3rd percentile (HP:0003561)	1.88208801
69	Decreased central vision (HP:0007663)	1.87339006
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87104205
71	Abnormality of T cells (HP:0002843)	1.84319858
72	Vitreoretinal degeneration (HP:0000655)	1.83118019
73	Abnormality of the fingertips (HP:0001211)	1.82892730
74	Exertional dyspnea (HP:0002875)	1.82219500
75	Intestinal atresia (HP:0011100)	1.82105799
76	Abnormal number of erythroid precursors (HP:0012131)	1.80334720
77	Abnormality of glycine metabolism (HP:0010895)	1.78214847
78	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78214847
79	Macular degeneration (HP:0000608)	1.77789869
80	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.73152929
81	Abnormality of serum amino acid levels (HP:0003112)	1.72544021
82	Triphalangeal thumb (HP:0001199)	1.72395751
83	Facial hemangioma (HP:0000329)	1.72386341
84	Thyroid-stimulating hormone excess (HP:0002925)	1.71850454
85	Hepatocellular necrosis (HP:0001404)	1.71532507
86	Neutropenia (HP:0001875)	1.71243274
87	Methylmalonic acidemia (HP:0002912)	1.70741222
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.69358232
89	Oligodactyly (hands) (HP:0001180)	1.67095026
90	Cone-rod dystrophy (HP:0000548)	1.66535284
91	Abnormality of cells of the erythroid lineage (HP:0012130)	1.66303337
92	Congenital stationary night blindness (HP:0007642)	1.65851963
93	Attenuation of retinal blood vessels (HP:0007843)	1.65370693
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.65356398
95	Short tibia (HP:0005736)	1.64477948
96	Glycosuria (HP:0003076)	1.62950546
97	Abnormality of urine glucose concentration (HP:0011016)	1.62950546
98	Sloping forehead (HP:0000340)	1.62461709
99	Type II lissencephaly (HP:0007260)	1.60505429
100	Abnormality of the pons (HP:0007361)	1.60396252

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	4.68951287
2	MKNK1	3.17782740
3	PLK4	3.12619223
4	EIF2AK3	2.91416530
5	AKT3	2.71508067
6	SRPK1	2.52214155
7	NUAK1	2.39598668
8	TSSK6	2.17318535
9	MST4	2.13074039
10	FRK	2.09976915
11	WNK3	2.00405746
12	BRD4	1.96969543
13	ZAK	1.90606027
14	TRIM28	1.71182154
15	PASK	1.69964054
16	EIF2AK1	1.69652600
17	ERBB3	1.64194046
18	NLK	1.62903829
19	STK39	1.62244701
20	TAOK3	1.61923765
21	OXSR1	1.56915828
22	TAF1	1.49175934
23	TNIK	1.46682776
24	CSNK1A1L	1.44802223
25	TEC	1.44537922
26	CSNK1G1	1.41557987
27	TXK	1.39169136
28	ADRBK2	1.34562326
29	MAP3K4	1.33059317
30	PAK3	1.32313900
31	RPS6KA4	1.30924034
32	SGK2	1.29760024
33	EIF2AK2	1.27727114
34	STK4	1.26150895
35	GRK1	1.23741621
36	ACVR1B	1.23651663
37	INSRR	1.21895162
38	PDK2	1.21391595
39	VRK1	1.20158456
40	TLK1	1.19848489
41	BMPR2	1.18940422
42	BUB1	1.16528855
43	CSNK1G3	1.16031643
44	DYRK3	1.14073944
45	STK16	1.08331304
46	PLK3	1.07976854
47	NEK1	1.07389582
48	WEE1	1.00296193
49	ATR	0.97801335
50	VRK2	0.95137876
51	PBK	0.93501387
52	SIK3	0.91813646
53	BCR	0.88157443
54	TGFBR1	0.87644925
55	WNK4	0.85359369
56	ITK	0.85349130
57	IRAK4	0.79579480
58	CHUK	0.78272812
59	PLK2	0.77840431
60	BMPR1B	0.76306949
61	IKBKB	0.75586824
62	RPS6KA5	0.71416865
63	MAP4K2	0.71270664
64	TIE1	0.70487027
65	MAP3K14	0.64878872
66	CSNK1G2	0.64523827
67	SGK3	0.61674315
68	CDK6	0.59519173
69	ATM	0.58168097
70	RPS6KB2	0.57597513
71	MAPK13	0.56155732
72	IKBKE	0.55354290
73	CASK	0.55038979
74	OBSCN	0.54768757
75	SGK494	0.53967835
76	SGK223	0.53967835
77	ALK	0.53811023
78	BRSK2	0.53068331
79	BTK	0.53030141
80	CAMK4	0.52756007
81	IRAK1	0.50613060
82	NEK6	0.46608480
83	WNK1	0.45954782
84	PIM1	0.45581350
85	MELK	0.44454990
86	PLK1	0.42627067
87	STK38L	0.42035665
88	TNK2	0.41794225
89	CLK1	0.41512431
90	CSNK1D	0.39420976
91	PIK3CG	0.38734838
92	DAPK2	0.37905480
93	CAMKK2	0.35541677
94	CHEK2	0.35370260
95	STK24	0.34492637
96	MAPKAPK3	0.30777655
97	CHEK1	0.30076108
98	CDK19	0.29640398
99	RPS6KB1	0.28661092
100	CDK4	0.26359704

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.89862493
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.73648013
3	RNA polymerase_Homo sapiens_hsa03020	3.34940295
4	Proteasome_Homo sapiens_hsa03050	3.21486890
5	RNA degradation_Homo sapiens_hsa03018	2.81860698
6	RNA transport_Homo sapiens_hsa03013	2.76936406
7	Asthma_Homo sapiens_hsa05310	2.57285910
8	Basal transcription factors_Homo sapiens_hsa03022	2.50538225
9	Ribosome_Homo sapiens_hsa03010	2.40305417
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.14258028
11	One carbon pool by folate_Homo sapiens_hsa00670	1.98132778
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.95722320
13	Allograft rejection_Homo sapiens_hsa05330	1.94265106
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.81274679
15	Propanoate metabolism_Homo sapiens_hsa00640	1.79137753
16	Mismatch repair_Homo sapiens_hsa03430	1.78235902
17	Spliceosome_Homo sapiens_hsa03040	1.67052798
18	Regulation of autophagy_Homo sapiens_hsa04140	1.66994682
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65615821
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.60648940
21	Homologous recombination_Homo sapiens_hsa03440	1.59473339
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55873217
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.49400417
24	Purine metabolism_Homo sapiens_hsa00230	1.37108333
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.34500640
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31306599
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.30372785
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28450685
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.28269181
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26028379
31	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.25338036
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.20975752
33	DNA replication_Homo sapiens_hsa03030	1.20550130
34	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.19036441
35	Sulfur metabolism_Homo sapiens_hsa00920	1.17610130
36	Phototransduction_Homo sapiens_hsa04744	1.16817327
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.15783658
38	p53 signaling pathway_Homo sapiens_hsa04115	1.09110992
39	Circadian rhythm_Homo sapiens_hsa04710	1.05222764
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.04874402
41	Base excision repair_Homo sapiens_hsa03410	1.03853846
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01896258
43	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.99518798
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99308083
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98883541
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96594938
47	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.96262586
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95451423
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.91803037
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90622842
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89718850
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88565891
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.86403524
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86039682
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84686626
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.83242811
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.82098847
58	Cell cycle_Homo sapiens_hsa04110	0.79422871
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78412106
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77885533
61	Measles_Homo sapiens_hsa05162	0.75800480
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74567269
63	Huntingtons disease_Homo sapiens_hsa05016	0.72624659
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66152305
65	Nicotine addiction_Homo sapiens_hsa05033	0.66148040
66	Peroxisome_Homo sapiens_hsa04146	0.63023659
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62935046
68	Viral carcinogenesis_Homo sapiens_hsa05203	0.61581360
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58336387
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56470991
71	Parkinsons disease_Homo sapiens_hsa05012	0.55019370
72	Caffeine metabolism_Homo sapiens_hsa00232	0.53552141
73	Alcoholism_Homo sapiens_hsa05034	0.52755610
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51412062
75	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.49835160
76	Legionellosis_Homo sapiens_hsa05134	0.49649216
77	Prostate cancer_Homo sapiens_hsa05215	0.47998743
78	TNF signaling pathway_Homo sapiens_hsa04668	0.47771097
79	Olfactory transduction_Homo sapiens_hsa04740	0.47439811
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46646496
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45596310
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45550241
83	ABC transporters_Homo sapiens_hsa02010	0.42254045
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41306736
85	Herpes simplex infection_Homo sapiens_hsa05168	0.41281009
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41149254
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40002137
88	Colorectal cancer_Homo sapiens_hsa05210	0.39068028
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.37599206
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35935815
91	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33466188
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.33034260
93	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.30677658
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30045956
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29086182
96	HTLV-I infection_Homo sapiens_hsa05166	0.28546728
97	Metabolic pathways_Homo sapiens_hsa01100	0.27899816
98	Retinol metabolism_Homo sapiens_hsa00830	0.27404008
99	Lysine degradation_Homo sapiens_hsa00310	0.25459128
100	Taste transduction_Homo sapiens_hsa04742	0.23070681

NPM1P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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