ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kinetochore assembly (GO:0051382)	6.06188469
2	positive regulation of action potential (GO:0045760)	5.62223891
3	kinetochore organization (GO:0051383)	5.56084992
4	maintenance of gastrointestinal epithelium (GO:0030277)	5.52477794
5	CENP-A containing nucleosome assembly (GO:0034080)	5.17386250
6	regulation of G0 to G1 transition (GO:0070316)	5.13089815
7	chromatin remodeling at centromere (GO:0031055)	4.81757469
8	inner ear receptor cell development (GO:0060119)	4.77957105
9	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	4.56510000
10	DNA strand renaturation (GO:0000733)	4.36817081
11	nephron tubule formation (GO:0072079)	4.34704217
12	magnesium ion transport (GO:0015693)	4.30528277
13	nephron tubule morphogenesis (GO:0072078)	4.25390576
14	nephron epithelium morphogenesis (GO:0072088)	4.25390576
15	negative regulation of metanephros development (GO:0072217)	4.22605384
16	protein targeting to Golgi (GO:0000042)	4.12966648
17	establishment of protein localization to Golgi (GO:0072600)	4.07170328
18	histone exchange (GO:0043486)	4.05889227
19	positive regulation of prostaglandin secretion (GO:0032308)	4.04129485
20	regulation of acrosome reaction (GO:0060046)	4.03634099
21	response to vitamin A (GO:0033189)	3.96423046
22	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.93707889
23	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.89451035
24	cGMP-mediated signaling (GO:0019934)	3.86585840
25	positive regulation of fatty acid transport (GO:2000193)	3.82765069
26	negative regulation of T cell differentiation in thymus (GO:0033085)	3.80969991
27	positive regulation of icosanoid secretion (GO:0032305)	3.77829710
28	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.77536950
29	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.74995978
30	regulation of DNA endoreduplication (GO:0032875)	3.73908645
31	rRNA catabolic process (GO:0016075)	3.73198873
32	valine metabolic process (GO:0006573)	3.72050946
33	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.64877878
34	trivalent inorganic anion homeostasis (GO:0072506)	3.59517409
35	phosphate ion homeostasis (GO:0055062)	3.59517409
36	protein-cofactor linkage (GO:0018065)	3.59384004
37	parturition (GO:0007567)	3.58704159
38	epithelial structure maintenance (GO:0010669)	3.57908531
39	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.53190527
40	DNA replication-independent nucleosome assembly (GO:0006336)	3.52401864
41	DNA replication-independent nucleosome organization (GO:0034724)	3.52401864
42	protein localization to Golgi apparatus (GO:0034067)	3.45627242
43	fusion of sperm to egg plasma membrane (GO:0007342)	3.44696071
44	regulation of prostaglandin secretion (GO:0032306)	3.39600034
45	double-strand break repair via homologous recombination (GO:0000724)	3.25655039
46	recombinational repair (GO:0000725)	3.24592836
47	membrane repolarization during action potential (GO:0086011)	3.19420338
48	termination of RNA polymerase I transcription (GO:0006363)	3.17685669
49	DNA deamination (GO:0045006)	3.12553967
50	ribosome assembly (GO:0042255)	3.11585070
51	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.10959674
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10759580
53	termination of RNA polymerase III transcription (GO:0006386)	3.10759580
54	O-glycan processing (GO:0016266)	3.09163183
55	interferon-gamma secretion (GO:0072643)	3.08825328
56	cellular anion homeostasis (GO:0030002)	3.08605929
57	retinal cone cell development (GO:0046549)	3.05059350
58	mitotic cytokinesis (GO:0000281)	3.04765769
59	regulation of action potential (GO:0098900)	3.03655670
60	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.02878592
61	renal tubule morphogenesis (GO:0061333)	3.01008453
62	DNA replication checkpoint (GO:0000076)	2.96436694
63	telomere maintenance via telomerase (GO:0007004)	2.95265299
64	7-methylguanosine mRNA capping (GO:0006370)	2.91746282
65	regulation of icosanoid secretion (GO:0032303)	2.90213779
66	negative regulation of multicellular organism growth (GO:0040015)	2.89972566
67	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.89343465
68	7-methylguanosine RNA capping (GO:0009452)	2.88980117
69	RNA capping (GO:0036260)	2.88980117
70	positive regulation of protein targeting to membrane (GO:0090314)	2.88574415
71	positive regulation of digestive system process (GO:0060456)	2.88557922
72	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.88267064
73	positive regulation of muscle cell apoptotic process (GO:0010661)	2.87407562
74	cardiovascular system development (GO:0072358)	2.86907499
75	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.85010604
76	negative regulation of protein autophosphorylation (GO:0031953)	2.78189888
77	microtubule depolymerization (GO:0007019)	2.77616250
78	urogenital system development (GO:0001655)	2.77241241
79	inner mitochondrial membrane organization (GO:0007007)	2.76796490
80	motile cilium assembly (GO:0044458)	2.71861830
81	chromatin assembly or disassembly (GO:0006333)	2.71308824
82	piRNA metabolic process (GO:0034587)	2.70414112
83	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.68796464
84	cornea development in camera-type eye (GO:0061303)	2.67623326
85	centriole replication (GO:0007099)	2.65983600
86	transcription from RNA polymerase I promoter (GO:0006360)	2.64609448
87	regulation of MHC class I biosynthetic process (GO:0045343)	2.63450307
88	apoptotic DNA fragmentation (GO:0006309)	2.63076800
89	galactose catabolic process (GO:0019388)	2.62639368
90	negative regulation of macrophage differentiation (GO:0045650)	2.59283856
91	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.58974551
92	replicative senescence (GO:0090399)	2.58358710
93	DNA demethylation (GO:0080111)	2.56122591
94	rRNA methylation (GO:0031167)	2.55573377
95	negative regulation of kidney development (GO:0090185)	2.55442960
96	ATP-dependent chromatin remodeling (GO:0043044)	2.55011704
97	ribosome biogenesis (GO:0042254)	2.54874523
98	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.54595142
99	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.54472189
100	DNA double-strand break processing (GO:0000729)	2.54109267

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.24030498
2	VDR_22108803_ChIP-Seq_LS180_Human	4.70352695
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.60187092
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.52375593
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.02264696
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.87801785
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.79785719
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65249393
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.51063245
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.43084480
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.42197076
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.33015214
13	EWS_26573619_Chip-Seq_HEK293_Human	2.31369974
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.27934076
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26589529
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.20873926
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18710398
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.15602697
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06509743
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01879854
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.97879801
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.93790831
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79661950
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.77709858
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.75641634
26	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.75110041
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74263119
28	P300_19829295_ChIP-Seq_ESCs_Human	1.73094998
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71615458
30	FUS_26573619_Chip-Seq_HEK293_Human	1.69994762
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.66744399
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64206251
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.59727464
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.59727464
35	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.56150965
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.52503347
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49981852
38	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.49568010
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49519130
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.49502501
41	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.48925036
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47668764
43	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.44709869
44	HOXB7_26014856_ChIP-Seq_BT474_Human	1.43365167
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40510160
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39899418
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39843161
48	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36601380
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36081452
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35432410
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35233909
52	AR_21572438_ChIP-Seq_LNCaP_Human	1.34311592
53	NCOR_22424771_ChIP-Seq_293T_Human	1.33600529
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32569471
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.28721474
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28698703
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27782743
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.25475178
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24571415
60	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23578799
61	SMRT_27268052_Chip-Seq_Bcells_Human	1.23227398
62	TCF4_23295773_ChIP-Seq_U87_Human	1.21245592
63	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.21039431
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19455750
65	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.18688132
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18607236
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16071762
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15692333
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.15692333
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15604693
71	AR_25329375_ChIP-Seq_VCAP_Human	1.13229878
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11816529
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11364906
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11147411
75	STAT3_23295773_ChIP-Seq_U87_Human	1.09867762
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07624849
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07624849
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04343575
79	ERA_21632823_ChIP-Seq_H3396_Human	1.04203971
80	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.03642279
81	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.00339005
82	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.99487064
83	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98891023
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98404945
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97059771
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94533080
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94079129
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94064030
89	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.93945931
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91562379
91	TP53_16413492_ChIP-PET_HCT116_Human	0.91283255
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90350252
93	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.90001616
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89941073
95	CBP_21632823_ChIP-Seq_H3396_Human	0.89435623
96	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.89061871
97	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88982618
98	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.88223135
99	AR_20517297_ChIP-Seq_VCAP_Human	0.87739013
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.87227527

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.06962719
2	MP0002138_abnormal_hepatobiliary_system	4.15767112
3	MP0004043_abnormal_pH_regulation	3.39229050
4	MP0000569_abnormal_digit_pigmentation	3.27079125
5	MP0002102_abnormal_ear_morphology	3.20685082
6	MP0003879_abnormal_hair_cell	3.14093140
7	MP0003195_calcinosis	2.97030464
8	MP0002160_abnormal_reproductive_system	2.84124196
9	MP0010094_abnormal_chromosome_stability	2.53708022
10	MP0002396_abnormal_hematopoietic_system	2.46642408
11	MP0008004_abnormal_stomach_pH	2.36247185
12	MP0000465_gastrointestinal_hemorrhage	2.29013775
13	MP0004019_abnormal_vitamin_homeostasis	2.28421623
14	MP0005646_abnormal_pituitary_gland	2.14758965
15	MP0008877_abnormal_DNA_methylation	2.00527317
16	MP0003866_abnormal_defecation	1.96326309
17	MP0001881_abnormal_mammary_gland	1.95745432
18	MP0009697_abnormal_copulation	1.94512890
19	MP0001485_abnormal_pinna_reflex	1.87302908
20	MP0008057_abnormal_DNA_replication	1.86969988
21	MP0005389_reproductive_system_phenotype	1.74770482
22	MP0000579_abnormal_nail_morphology	1.73428333
23	MP0001293_anophthalmia	1.72158594
24	MP0010386_abnormal_urinary_bladder	1.68204095
25	MP0001873_stomach_inflammation	1.67120748
26	MP0008872_abnormal_physiological_respon	1.61992372
27	MP0002234_abnormal_pharynx_morphology	1.58041719
28	MP0008058_abnormal_DNA_repair	1.52407626
29	MP0002095_abnormal_skin_pigmentation	1.47060032
30	MP0003936_abnormal_reproductive_system	1.45399255
31	MP0003890_abnormal_embryonic-extraembry	1.45068946
32	MP0003937_abnormal_limbs/digits/tail_de	1.43490205
33	MP0002277_abnormal_respiratory_mucosa	1.39907436
34	MP0001765_abnormal_ion_homeostasis	1.35179144
35	MP0004134_abnormal_chest_morphology	1.32058827
36	MP0003786_premature_aging	1.29825545
37	MP0002254_reproductive_system_inflammat	1.29792446
38	MP0000627_abnormal_mammary_gland	1.29125960
39	MP0003693_abnormal_embryo_hatching	1.29098839
40	MP0003111_abnormal_nucleus_morphology	1.28786492
41	MP0002876_abnormal_thyroid_physiology	1.26957570
42	MP0005084_abnormal_gallbladder_morpholo	1.25640619
43	MP0000631_abnormal_neuroendocrine_gland	1.25527837
44	MP0005083_abnormal_biliary_tract	1.21268428
45	MP0005636_abnormal_mineral_homeostasis	1.20649057
46	MP0004133_heterotaxia	1.17319232
47	MP0005076_abnormal_cell_differentiation	1.15244649
48	MP0004147_increased_porphyrin_level	1.12439122
49	MP0003878_abnormal_ear_physiology	1.12152065
50	MP0005377_hearing/vestibular/ear_phenot	1.12152065
51	MP0002837_dystrophic_cardiac_calcinosis	1.11608714
52	MP0002272_abnormal_nervous_system	1.10745084
53	MP0002928_abnormal_bile_duct	1.10252560
54	MP0003011_delayed_dark_adaptation	1.09156488
55	MP0006035_abnormal_mitochondrial_morpho	1.08747190
56	MP0008007_abnormal_cellular_replicative	1.08470447
57	MP0003315_abnormal_perineum_morphology	1.07789875
58	MP0000372_irregular_coat_pigmentation	1.06677224
59	MP0002269_muscular_atrophy	1.05846787
60	MP0001666_abnormal_nutrient_absorption	1.04872191
61	MP0008995_early_reproductive_senescence	1.03575742
62	MP0001502_abnormal_circadian_rhythm	1.02991593
63	MP0004957_abnormal_blastocyst_morpholog	1.02552192
64	MP0002736_abnormal_nociception_after	1.01582874
65	MP0000026_abnormal_inner_ear	0.99883296
66	MP0001663_abnormal_digestive_system	0.94642423
67	MP0001664_abnormal_digestion	0.92102799
68	MP0008875_abnormal_xenobiotic_pharmacok	0.90992758
69	MP0004145_abnormal_muscle_electrophysio	0.90950343
70	MP0003252_abnormal_bile_duct	0.89508782
71	MP0005551_abnormal_eye_electrophysiolog	0.88023190
72	MP0000383_abnormal_hair_follicle	0.87868992
73	MP0008961_abnormal_basal_metabolism	0.87218402
74	MP0000685_abnormal_immune_system	0.84854710
75	MP0002177_abnormal_outer_ear	0.84654505
76	MP0009046_muscle_twitch	0.83487065
77	MP0000427_abnormal_hair_cycle	0.83333263
78	MP0001542_abnormal_bone_strength	0.80137725
79	MP0001764_abnormal_homeostasis	0.78676924
80	MP0010155_abnormal_intestine_physiology	0.77285320
81	MP0002229_neurodegeneration	0.76679794
82	MP0000371_diluted_coat_color	0.76154663
83	MP0002098_abnormal_vibrissa_morphology	0.75085352
84	MP0003943_abnormal_hepatobiliary_system	0.73123602
85	MP0001968_abnormal_touch/_nociception	0.72542576
86	MP0000049_abnormal_middle_ear	0.72385763
87	MP0004510_myositis	0.72304532
88	MP0005310_abnormal_salivary_gland	0.71598258
89	MP0002249_abnormal_larynx_morphology	0.70938304
90	MP0002210_abnormal_sex_determination	0.68190200
91	MP0003718_maternal_effect	0.66976652
92	MP0003959_abnormal_lean_body	0.66013019
93	MP0003938_abnormal_ear_development	0.65965809
94	MP0003283_abnormal_digestive_organ	0.64047236
95	MP0005448_abnormal_energy_balance	0.62786813
96	MP0010678_abnormal_skin_adnexa	0.62684340
97	MP0003077_abnormal_cell_cycle	0.62579384
98	MP0005266_abnormal_metabolism	0.59223909
99	MP0001119_abnormal_female_reproductive	0.58843330
100	MP0004142_abnormal_muscle_tone	0.58459801

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	4.78743636
2	Morphological abnormality of the middle ear (HP:0008609)	4.34387169
3	Hyperacusis (HP:0010780)	3.68809372
4	Congenital sensorineural hearing impairment (HP:0008527)	3.49794917
5	Chronic hepatic failure (HP:0100626)	3.49719206
6	Tetany (HP:0001281)	3.48292645
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.43321672
8	Chromsome breakage (HP:0040012)	3.39561479
9	Hypomagnesemia (HP:0002917)	3.38577289
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.38209488
11	Abnormality of the carotid arteries (HP:0005344)	3.37630653
12	Broad face (HP:0000283)	3.33655316
13	Patent foramen ovale (HP:0001655)	3.30740191
14	Abnormality of the preputium (HP:0100587)	3.26078354
15	Vascular calcification (HP:0004934)	3.17433197
16	Abnormality of chromosome stability (HP:0003220)	3.04605646
17	Hypothermia (HP:0002045)	2.99537722
18	Meckel diverticulum (HP:0002245)	2.99447273
19	Spinal muscular atrophy (HP:0007269)	2.96807966
20	Facial cleft (HP:0002006)	2.92974505
21	Abnormality of the ileum (HP:0001549)	2.91659128
22	Self-mutilation (HP:0000742)	2.90383622
23	Abnormal drinking behavior (HP:0030082)	2.82521077
24	Polydipsia (HP:0001959)	2.82521077
25	Congenital stationary night blindness (HP:0007642)	2.79591500
26	Abnormality of the nasal septum (HP:0000419)	2.76333021
27	Clubbing of toes (HP:0100760)	2.74787410
28	Abnormality of midbrain morphology (HP:0002418)	2.67583834
29	Molar tooth sign on MRI (HP:0002419)	2.67583834
30	Clumsiness (HP:0002312)	2.67578237
31	Cardiovascular calcification (HP:0011915)	2.67554343
32	Abnormality of DNA repair (HP:0003254)	2.62039153
33	Stomatitis (HP:0010280)	2.59640576
34	Nephrocalcinosis (HP:0000121)	2.57704738
35	Urethral obstruction (HP:0000796)	2.56588496
36	Enlarged epiphyses (HP:0010580)	2.54008808
37	Pancreatic cysts (HP:0001737)	2.51251621
38	Abnormality of magnesium homeostasis (HP:0004921)	2.49025424
39	Pili torti (HP:0003777)	2.48944384
40	Sensory axonal neuropathy (HP:0003390)	2.48664716
41	Hypophosphatemic rickets (HP:0004912)	2.46246387
42	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.41769010
43	Short 1st metacarpal (HP:0010034)	2.41769010
44	Impulsivity (HP:0100710)	2.39653959
45	Renovascular hypertension (HP:0100817)	2.38203716
46	Premature ovarian failure (HP:0008209)	2.37515249
47	Palpebral edema (HP:0100540)	2.33507951
48	Tented upper lip vermilion (HP:0010804)	2.31915084
49	Abnormal number of incisors (HP:0011064)	2.31451481
50	Hyperuricemia (HP:0002149)	2.29977981
51	Increased purine levels (HP:0004368)	2.29977981
52	Chronic bronchitis (HP:0004469)	2.25953598
53	Astigmatism (HP:0000483)	2.24927367
54	Volvulus (HP:0002580)	2.21356593
55	Abnormality of the 1st metacarpal (HP:0010009)	2.20620893
56	Congenital, generalized hypertrichosis (HP:0004540)	2.19139740
57	Hypercalciuria (HP:0002150)	2.15216192
58	Duodenal stenosis (HP:0100867)	2.12756881
59	Small intestinal stenosis (HP:0012848)	2.12756881
60	Abnormal biliary tract physiology (HP:0012439)	2.07722930
61	Bile duct proliferation (HP:0001408)	2.07722930
62	Abnormality of the renal collecting system (HP:0004742)	2.07124310
63	Duplicated collecting system (HP:0000081)	2.06993048
64	Abnormality of the labia minora (HP:0012880)	2.03124663
65	Nephronophthisis (HP:0000090)	2.03000566
66	Renal cortical cysts (HP:0000803)	2.01923044
67	Poor coordination (HP:0002370)	2.00967390
68	Abnormality of B cell number (HP:0010975)	1.94691078
69	True hermaphroditism (HP:0010459)	1.94434882
70	Alopecia of scalp (HP:0002293)	1.90379643
71	Median cleft lip (HP:0000161)	1.90027955
72	Abnormality of the renal cortex (HP:0011035)	1.89066993
73	Mask-like facies (HP:0000298)	1.88844794
74	Hypoplastic ischia (HP:0003175)	1.85523461
75	Hyperkalemia (HP:0002153)	1.85141684
76	Neonatal respiratory distress (HP:0002643)	1.84662561
77	Abnormal number of erythroid precursors (HP:0012131)	1.84360191
78	Medial flaring of the eyebrow (HP:0010747)	1.84199129
79	Severe combined immunodeficiency (HP:0004430)	1.83492057
80	Bell-shaped thorax (HP:0001591)	1.83360226
81	Hoarse voice (HP:0001609)	1.81879162
82	Absent thumb (HP:0009777)	1.80853285
83	Microretrognathia (HP:0000308)	1.80065378
84	Abnormality of the renal medulla (HP:0100957)	1.78751867
85	Short thumb (HP:0009778)	1.77651326
86	Hypergonadotropic hypogonadism (HP:0000815)	1.77564905
87	Small hand (HP:0200055)	1.77315766
88	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.77038566
89	Abnormality of the duodenum (HP:0002246)	1.74139789
90	Myelodysplasia (HP:0002863)	1.73598122
91	Oligodactyly (hands) (HP:0001180)	1.72643536
92	Abnormality of alanine metabolism (HP:0010916)	1.71422809
93	Hyperalaninemia (HP:0003348)	1.71422809
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71422809
95	Decreased central vision (HP:0007663)	1.70172626
96	Sloping forehead (HP:0000340)	1.69860502
97	Short chin (HP:0000331)	1.69022892
98	Pendular nystagmus (HP:0012043)	1.68949265
99	Esophageal atresia (HP:0002032)	1.68610952
100	Polyuria (HP:0000103)	1.68475180

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	5.32851326
2	MAP3K4	4.14459180
3	MAP2K7	3.84820391
4	NME1	3.73254448
5	MST1R	3.72013684
6	NEK2	3.35476960
7	CDK12	2.89226043
8	MST4	2.50322806
9	TSSK6	2.34322835
10	TAOK3	2.02437515
11	SIK2	1.92538173
12	MAP2K4	1.90117443
13	WNK3	1.87869785
14	WNK1	1.86355726
15	ZAK	1.83209305
16	NUAK1	1.80315830
17	CDC7	1.74702896
18	ABL2	1.60629441
19	EIF2AK3	1.55462215
20	MAP3K9	1.50513110
21	MAP3K6	1.38335629
22	TLK1	1.36795746
23	PLK3	1.33617666
24	PLK4	1.32662347
25	MAP2K6	1.31282706
26	EIF2AK1	1.24487746
27	PASK	1.24374918
28	VRK1	1.24180333
29	PLK1	1.20548893
30	PNCK	1.15651766
31	MKNK1	1.14851106
32	NTRK1	1.10918513
33	MKNK2	1.09028787
34	CDK7	1.06775035
35	BCKDK	1.05636438
36	TAF1	1.02079704
37	FRK	0.97363986
38	ADRBK2	0.96958214
39	PBK	0.96681892
40	AURKB	0.90967268
41	ACVR1B	0.89091582
42	MAP4K2	0.88714170
43	MAPKAPK3	0.83841847
44	TXK	0.80406025
45	BMPR1B	0.80304354
46	NEK1	0.79457114
47	OXSR1	0.77781944
48	WEE1	0.76279806
49	MAPK15	0.75962329
50	RPS6KA6	0.73749526
51	MET	0.72561462
52	PINK1	0.72404791
53	CHUK	0.69544629
54	VRK2	0.67963797
55	STK39	0.66458146
56	RET	0.64549426
57	SGK1	0.63135966
58	GRK1	0.62500891
59	PRKACB	0.61852879
60	EIF2AK2	0.58627872
61	PIK3CG	0.57585886
62	ALK	0.55755993
63	CHEK1	0.54550764
64	BRSK2	0.54531620
65	ATR	0.53562965
66	CSNK2A1	0.52423139
67	CSNK1E	0.52367475
68	PRKDC	0.52063833
69	DYRK3	0.51863744
70	TNIK	0.50413194
71	CHEK2	0.47864133
72	CSNK2A2	0.47568109
73	NTRK2	0.47384798
74	EPHA2	0.47212201
75	KIT	0.46266263
76	AKT2	0.46230410
77	ATM	0.46001882
78	PRKCI	0.45994753
79	INSRR	0.45188405
80	TTK	0.45029202
81	MUSK	0.44975215
82	NLK	0.44757220
83	RPS6KC1	0.44417832
84	RPS6KL1	0.44417832
85	RPS6KB2	0.43949417
86	ADRBK1	0.42293804
87	RPS6KA5	0.41917375
88	CDK3	0.41741307
89	TEC	0.35112975
90	CDK1	0.34320541
91	TRPM7	0.32778927
92	IKBKE	0.32599414
93	ERBB2	0.28405161
94	CDK2	0.28362874
95	CSNK1G1	0.28018643
96	BCR	0.27687839
97	SRPK1	0.27407039
98	IKBKB	0.23612703
99	TRIM28	0.23437639
100	PHKG2	0.21938024

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	4.20710051
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.02761561
3	Homologous recombination_Homo sapiens_hsa03440	3.26055626
4	One carbon pool by folate_Homo sapiens_hsa00670	2.94026670
5	Basal transcription factors_Homo sapiens_hsa03022	2.57636734
6	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.51815749
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.50336476
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45894821
9	Mismatch repair_Homo sapiens_hsa03430	2.45169460
10	DNA replication_Homo sapiens_hsa03030	2.29179187
11	RNA transport_Homo sapiens_hsa03013	2.17976440
12	RNA degradation_Homo sapiens_hsa03018	2.11419433
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02045294
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.95402231
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.87881544
16	Proteasome_Homo sapiens_hsa03050	1.83275442
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82847706
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.79586433
19	Protein export_Homo sapiens_hsa03060	1.71844166
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.69892014
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.69630518
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48764369
23	Olfactory transduction_Homo sapiens_hsa04740	1.46264706
24	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.43075778
25	Purine metabolism_Homo sapiens_hsa00230	1.42696282
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40569010
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.31903766
28	Propanoate metabolism_Homo sapiens_hsa00640	1.29861966
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.29148276
30	Asthma_Homo sapiens_hsa05310	1.22583721
31	Base excision repair_Homo sapiens_hsa03410	1.19802711
32	Allograft rejection_Homo sapiens_hsa05330	1.17790765
33	Regulation of autophagy_Homo sapiens_hsa04140	1.15344401
34	Spliceosome_Homo sapiens_hsa03040	1.12777882
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.04117514
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03003930
37	Salivary secretion_Homo sapiens_hsa04970	1.02856102
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01750269
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.00570762
40	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99950879
41	Huntingtons disease_Homo sapiens_hsa05016	0.97806291
42	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94856710
43	ABC transporters_Homo sapiens_hsa02010	0.94708727
44	Phototransduction_Homo sapiens_hsa04744	0.93646881
45	Oocyte meiosis_Homo sapiens_hsa04114	0.93124621
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92628759
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91607418
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.90239643
49	Tight junction_Homo sapiens_hsa04530	0.87950455
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.86847507
51	Taste transduction_Homo sapiens_hsa04742	0.84982603
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.83056812
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.81739334
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79628589
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.76919751
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.76542808
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.72809041
58	Mineral absorption_Homo sapiens_hsa04978	0.65603906
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.65348201
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.65005284
61	Caffeine metabolism_Homo sapiens_hsa00232	0.57776302
62	Ribosome_Homo sapiens_hsa03010	0.56955364
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54170825
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53885549
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.53462359
66	Serotonergic synapse_Homo sapiens_hsa04726	0.52391772
67	Sulfur metabolism_Homo sapiens_hsa00920	0.52043521
68	Retinol metabolism_Homo sapiens_hsa00830	0.51385521
69	Herpes simplex infection_Homo sapiens_hsa05168	0.51234069
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50205561
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49533733
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48847619
73	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45486481
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41365147
75	Oxidative phosphorylation_Homo sapiens_hsa00190	0.39968868
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39208209
77	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.38879953
78	Cell cycle_Homo sapiens_hsa04110	0.38503289
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37524415
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37205175
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36372185
82	Circadian entrainment_Homo sapiens_hsa04713	0.36189019
83	Nicotine addiction_Homo sapiens_hsa05033	0.34221257
84	p53 signaling pathway_Homo sapiens_hsa04115	0.33199055
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31799016
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.31351863
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30376547
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30142865
89	Gastric acid secretion_Homo sapiens_hsa04971	0.29930323
90	African trypanosomiasis_Homo sapiens_hsa05143	0.29436146
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29377130
92	Lysine degradation_Homo sapiens_hsa00310	0.27222646
93	Measles_Homo sapiens_hsa05162	0.26251590
94	Parkinsons disease_Homo sapiens_hsa05012	0.25556210
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24736931
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.23887744
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23826819
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23458950
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.23311957
100	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20734254

NPM1P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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