NPM1P29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.58473741
2rRNA methylation (GO:0031167)5.43303736
3rRNA modification (GO:0000154)5.38358937
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.06689322
5ribosome assembly (GO:0042255)4.89651589
6maturation of 5.8S rRNA (GO:0000460)4.86739885
7regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.74917398
8regulation of isotype switching to IgG isotypes (GO:0048302)4.64003860
9DNA deamination (GO:0045006)4.51104033
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.46976056
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.20838103
12transcription elongation from RNA polymerase I promoter (GO:0006362)4.18968215
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.07465083
14positive regulation of isotype switching (GO:0045830)3.99905443
15termination of RNA polymerase I transcription (GO:0006363)3.97423660
16DNA double-strand break processing (GO:0000729)3.97188381
17chaperone-mediated protein transport (GO:0072321)3.97127156
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.86259783
19cullin deneddylation (GO:0010388)3.80925000
20regulation of chronic inflammatory response (GO:0002676)3.78498726
21regulation of immunoglobulin secretion (GO:0051023)3.74545069
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.70761728
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70409014
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68855987
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68855987
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68855987
27positive regulation of DNA recombination (GO:0045911)3.65799443
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64752208
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64752208
30regulation of cellular amino acid metabolic process (GO:0006521)3.62221985
31protein deneddylation (GO:0000338)3.61936799
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59768216
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58260860
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.54512431
35isotype switching (GO:0045190)3.54512431
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.54512431
37IMP biosynthetic process (GO:0006188)3.52737198
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.52499279
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.52499279
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.50169292
41termination of RNA polymerase III transcription (GO:0006386)3.50169292
42negative regulation of ligase activity (GO:0051352)3.48749479
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48749479
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.48249272
45transcription initiation from RNA polymerase I promoter (GO:0006361)3.47545434
46rRNA processing (GO:0006364)3.44576451
47ribosome biogenesis (GO:0042254)3.41537563
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.36984397
49rRNA metabolic process (GO:0016072)3.36451075
50DNA catabolic process, exonucleolytic (GO:0000738)3.34668182
51mitochondrial RNA metabolic process (GO:0000959)3.25123706
52pseudouridine synthesis (GO:0001522)3.24798404
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21230782
54DNA damage response, detection of DNA damage (GO:0042769)3.19144900
55protein neddylation (GO:0045116)3.17047839
56transcription from RNA polymerase I promoter (GO:0006360)3.16886659
57chromatin remodeling at centromere (GO:0031055)3.14969556
58CENP-A containing nucleosome assembly (GO:0034080)3.14038332
59amino acid activation (GO:0043038)3.13165240
60tRNA aminoacylation (GO:0043039)3.13165240
61histone mRNA metabolic process (GO:0008334)3.12879542
62IMP metabolic process (GO:0046040)3.10502214
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06931672
64tRNA aminoacylation for protein translation (GO:0006418)3.04820830
65transcription from mitochondrial promoter (GO:0006390)3.01403490
66GTP biosynthetic process (GO:0006183)2.98093838
67regulation of mitotic spindle checkpoint (GO:1903504)2.97206543
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97206543
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.93828136
70positive regulation of ligase activity (GO:0051351)2.91466510
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.90804677
72tRNA metabolic process (GO:0006399)2.88692862
73organelle disassembly (GO:1903008)2.87904696
74protein targeting to mitochondrion (GO:0006626)2.87128143
75positive regulation of immunoglobulin mediated immune response (GO:0002891)2.86776986
76positive regulation of B cell mediated immunity (GO:0002714)2.86776986
77water-soluble vitamin biosynthetic process (GO:0042364)2.86404527
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85734234
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85734234
80regulation of regulatory T cell differentiation (GO:0045589)2.85399441
81ncRNA metabolic process (GO:0034660)2.83627144
82double-strand break repair via homologous recombination (GO:0000724)2.83227414
83telomere maintenance via telomerase (GO:0007004)2.81895138
84recombinational repair (GO:0000725)2.81538054
85positive regulation of cell cycle arrest (GO:0071158)2.80078983
86ncRNA processing (GO:0034470)2.79883893
87tRNA processing (GO:0008033)2.79627285
88spliceosomal snRNP assembly (GO:0000387)2.79067704
89intracellular protein transmembrane import (GO:0044743)2.78867616
90regulation of helicase activity (GO:0051095)2.77192821
91regulation of podosome assembly (GO:0071801)2.76790324
92DNA replication checkpoint (GO:0000076)2.75316261
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.74142884
94ribosomal large subunit biogenesis (GO:0042273)2.73683291
95DNA-templated transcription, termination (GO:0006353)2.73581151
96somatic recombination of immunoglobulin gene segments (GO:0016447)2.72293915
97histone exchange (GO:0043486)2.71376298
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69783386
99peptidyl-histidine modification (GO:0018202)2.68588412
100folic acid-containing compound biosynthetic process (GO:0009396)2.67819843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67111966
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.18490034
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.68685817
4E2F7_22180533_ChIP-Seq_HELA_Human3.02786813
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90011666
6ELK1_19687146_ChIP-ChIP_HELA_Human2.85662394
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.71956285
8VDR_23849224_ChIP-Seq_CD4+_Human2.69885220
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66940739
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47545555
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46967499
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.46432464
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36053645
14VDR_22108803_ChIP-Seq_LS180_Human2.29301315
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.25880445
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22313169
17EWS_26573619_Chip-Seq_HEK293_Human2.22087267
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19868723
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.12227368
20ZNF274_21170338_ChIP-Seq_K562_Hela2.11960272
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09956700
22FOXP3_21729870_ChIP-Seq_TREG_Human2.05093800
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99380783
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92613217
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91500701
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90905343
27TAF15_26573619_Chip-Seq_HEK293_Human1.88658188
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84806896
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83136537
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81111642
31FUS_26573619_Chip-Seq_HEK293_Human1.75787628
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74841098
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63851769
34DCP1A_22483619_ChIP-Seq_HELA_Human1.60965594
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56217054
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55753730
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.55744543
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54114051
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53207150
40MYC_18940864_ChIP-ChIP_HL60_Human1.51408330
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49735161
42P300_19829295_ChIP-Seq_ESCs_Human1.49490791
43IGF1R_20145208_ChIP-Seq_DFB_Human1.49020396
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45045682
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41557469
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40486605
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.40040861
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39504413
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.36043027
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33668909
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33456894
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28663629
53TTF2_22483619_ChIP-Seq_HELA_Human1.26573670
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25304856
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23399127
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23206720
57GABP_19822575_ChIP-Seq_HepG2_Human1.19708215
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19193143
59ER_23166858_ChIP-Seq_MCF-7_Human1.18651974
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15323639
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15070837
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13873353
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.13857377
64TP53_22573176_ChIP-Seq_HFKS_Human1.12009903
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06716209
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.05572881
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05287405
68SOX2_19829295_ChIP-Seq_ESCs_Human1.05251409
69NANOG_19829295_ChIP-Seq_ESCs_Human1.05251409
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03879732
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03719084
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03560946
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.02887897
74P53_22387025_ChIP-Seq_ESCs_Mouse1.01619225
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01317061
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01213384
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00659581
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00352287
79P300_18555785_Chip-Seq_ESCs_Mouse0.99505242
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98425484
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.98425484
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97615772
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96038982
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95600076
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95432876
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.95273336
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94839430
88CBP_20019798_ChIP-Seq_JUKART_Human0.94839430
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94211946
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93212723
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93132572
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.92514187
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92509090
94NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92192512
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90722408
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.89925254
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89856712
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.89665159
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89610817
100IRF1_19129219_ChIP-ChIP_H3396_Human0.89502987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.01283771
2MP0001835_abnormal_antigen_presentation3.42092809
3MP0008058_abnormal_DNA_repair3.36646041
4MP0008877_abnormal_DNA_methylation3.19542738
5MP0002102_abnormal_ear_morphology3.03115790
6MP0010094_abnormal_chromosome_stability2.66512537
7MP0000569_abnormal_digit_pigmentation2.62292287
8MP0004957_abnormal_blastocyst_morpholog2.55685302
9MP0003693_abnormal_embryo_hatching2.43366996
10MP0003786_premature_aging2.31034886
11MP0001984_abnormal_olfaction2.30555704
12MP0003718_maternal_effect2.10927132
13MP0003077_abnormal_cell_cycle2.08198064
14MP0002006_tumorigenesis2.04845275
15MP0009697_abnormal_copulation1.96567388
16MP0001853_heart_inflammation1.93780112
17MP0001873_stomach_inflammation1.80475637
18MP0003111_abnormal_nucleus_morphology1.77880275
19MP0008007_abnormal_cellular_replicative1.73603305
20MP0001529_abnormal_vocalization1.73284001
21MP0002166_altered_tumor_susceptibility1.73176380
22MP0003567_abnormal_fetal_cardiomyocyte1.72435690
23MP0006072_abnormal_retinal_apoptosis1.70185866
24MP0008872_abnormal_physiological_respon1.69797396
25MP0000685_abnormal_immune_system1.69245261
26MP0003195_calcinosis1.65026755
27MP0000372_irregular_coat_pigmentation1.64167366
28MP0006035_abnormal_mitochondrial_morpho1.63405237
29MP0006054_spinal_hemorrhage1.59514075
30MP0006036_abnormal_mitochondrial_physio1.57963223
31MP0003787_abnormal_imprinting1.50651476
32MP0003806_abnormal_nucleotide_metabolis1.48092580
33MP0004381_abnormal_hair_follicle1.47714788
34MP0005408_hypopigmentation1.47654896
35MP0000427_abnormal_hair_cycle1.40595503
36MP0006276_abnormal_autonomic_nervous1.35483066
37MP0005671_abnormal_response_to1.33488503
38MP0008875_abnormal_xenobiotic_pharmacok1.32166090
39MP0005645_abnormal_hypothalamus_physiol1.31880745
40MP0003186_abnormal_redox_activity1.31317645
41MP0009785_altered_susceptibility_to1.31103186
42MP0001881_abnormal_mammary_gland1.30841607
43MP0003011_delayed_dark_adaptation1.28129276
44MP0005075_abnormal_melanosome_morpholog1.27687795
45MP0003121_genomic_imprinting1.22594411
46MP0001293_anophthalmia1.22007948
47MP0003646_muscle_fatigue1.21368694
48MP0008932_abnormal_embryonic_tissue1.20298899
49MP0000604_amyloidosis1.17913623
50MP0005310_abnormal_salivary_gland1.15971226
51MP0002751_abnormal_autonomic_nervous1.12988720
52MP0002148_abnormal_hypersensitivity_rea1.10454210
53MP0005253_abnormal_eye_physiology1.09823502
54MP0002277_abnormal_respiratory_mucosa1.07729992
55MP0002138_abnormal_hepatobiliary_system1.02689521
56MP0001800_abnormal_humoral_immune1.01752536
57MP0003300_gastrointestinal_ulcer1.00238970
58MP0004142_abnormal_muscle_tone0.98904828
59MP0006292_abnormal_olfactory_placode0.98718673
60MP0010352_gastrointestinal_tract_polyps0.97413253
61MP0002938_white_spotting0.97025830
62MP0005387_immune_system_phenotype0.96639769
63MP0001790_abnormal_immune_system0.96639769
64MP0003122_maternal_imprinting0.96124297
65MP0002163_abnormal_gland_morphology0.92746025
66MP0001929_abnormal_gametogenesis0.92289811
67MP0001188_hyperpigmentation0.88012147
68MP0001119_abnormal_female_reproductive0.85214239
69MP0002405_respiratory_system_inflammati0.85180939
70MP0002210_abnormal_sex_determination0.85005604
71MP0008873_increased_physiological_sensi0.84333908
72MP0005266_abnormal_metabolism0.82001175
73MP0008995_early_reproductive_senescence0.81976807
74MP0003763_abnormal_thymus_physiology0.80462243
75MP0009765_abnormal_xenobiotic_induced0.78940483
76MP0005551_abnormal_eye_electrophysiolog0.78838869
77MP0002693_abnormal_pancreas_physiology0.76561600
78MP0000689_abnormal_spleen_morphology0.75415553
79MP0003866_abnormal_defecation0.75326875
80MP0001730_embryonic_growth_arrest0.75283259
81MP0005410_abnormal_fertilization0.74408096
82MP0009764_decreased_sensitivity_to0.74353783
83MP0010307_abnormal_tumor_latency0.74304548
84MP0003890_abnormal_embryonic-extraembry0.73788284
85MP0000653_abnormal_sex_gland0.73274031
86MP0002019_abnormal_tumor_incidence0.72570492
87MP0003937_abnormal_limbs/digits/tail_de0.69272957
88MP0003221_abnormal_cardiomyocyte_apopto0.68874120
89MP0010386_abnormal_urinary_bladder0.68715881
90MP0000465_gastrointestinal_hemorrhage0.68538778
91MP0001348_abnormal_lacrimal_gland0.66944073
92MP0002736_abnormal_nociception_after0.66789871
93MP0000631_abnormal_neuroendocrine_gland0.65942046
94MP0002396_abnormal_hematopoietic_system0.65460107
95MP0000703_abnormal_thymus_morphology0.65456356
96MP0009333_abnormal_splenocyte_physiolog0.63557375
97MP0005379_endocrine/exocrine_gland_phen0.63161915
98MP0003936_abnormal_reproductive_system0.62508419
99MP0001145_abnormal_male_reproductive0.62020386
100MP0004782_abnormal_surfactant_physiolog0.61996816

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.29424205
2Acute necrotizing encephalopathy (HP:0006965)4.08309445
3Acute encephalopathy (HP:0006846)3.65149259
4Progressive macrocephaly (HP:0004481)3.64543299
5Abnormality of the labia minora (HP:0012880)3.54992069
6Increased CSF lactate (HP:0002490)3.51463275
7Pancreatic cysts (HP:0001737)3.39308934
8Abnormal mitochondria in muscle tissue (HP:0008316)3.33125922
9Mitochondrial inheritance (HP:0001427)3.28832834
10Increased hepatocellular lipid droplets (HP:0006565)3.09474863
11Hypoplasia of the pons (HP:0012110)3.02644946
12IgG deficiency (HP:0004315)2.96078553
13Lipid accumulation in hepatocytes (HP:0006561)2.89322236
14Abnormality of the pons (HP:0007361)2.89162891
15Molar tooth sign on MRI (HP:0002419)2.83742196
16Abnormality of midbrain morphology (HP:0002418)2.83742196
17Colon cancer (HP:0003003)2.79192033
18Posterior subcapsular cataract (HP:0007787)2.74102426
19Increased serum lactate (HP:0002151)2.70034926
203-Methylglutaconic aciduria (HP:0003535)2.66240304
21Pancreatic fibrosis (HP:0100732)2.62704682
22Exertional dyspnea (HP:0002875)2.58352939
23Methylmalonic acidemia (HP:0002912)2.54912132
24Cerebral edema (HP:0002181)2.50278977
25Abnormality of alanine metabolism (HP:0010916)2.46401324
26Hyperalaninemia (HP:0003348)2.46401324
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46401324
28Nephronophthisis (HP:0000090)2.39789733
29Amniotic constriction ring (HP:0009775)2.37094968
30Abnormality of placental membranes (HP:0011409)2.37094968
31Optic disc pallor (HP:0000543)2.35750454
32Hepatocellular necrosis (HP:0001404)2.32011318
33Leukodystrophy (HP:0002415)2.30395591
34Progressive inability to walk (HP:0002505)2.28631905
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26581086
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24787932
37Methylmalonic aciduria (HP:0012120)2.20186110
38Sensory axonal neuropathy (HP:0003390)2.19893534
39Degeneration of anterior horn cells (HP:0002398)2.18274354
40Abnormality of the anterior horn cell (HP:0006802)2.18274354
41Abnormality of chromosome stability (HP:0003220)2.15494087
42True hermaphroditism (HP:0010459)2.09529209
43Congenital, generalized hypertrichosis (HP:0004540)2.08828833
44Type II lissencephaly (HP:0007260)2.08797616
45Thyroiditis (HP:0100646)2.08656354
46Hepatic necrosis (HP:0002605)2.08084674
47IgA deficiency (HP:0002720)2.07649661
48Renal Fanconi syndrome (HP:0001994)2.07036083
49Abnormality of the renal medulla (HP:0100957)2.06672661
50Pelvic girdle muscle weakness (HP:0003749)2.04680113
51Prominent metopic ridge (HP:0005487)2.04216961
52Type 2 muscle fiber atrophy (HP:0003554)2.03941604
53Cerebral hemorrhage (HP:0001342)2.01269753
54Abnormality of serum amino acid levels (HP:0003112)2.00916083
55Abnormality of methionine metabolism (HP:0010901)2.00463963
56Meckel diverticulum (HP:0002245)2.00348046
57Pendular nystagmus (HP:0012043)1.98609464
58Respiratory failure (HP:0002878)1.96091450
59Supernumerary spleens (HP:0009799)1.95663364
60Oligodactyly (hands) (HP:0001180)1.95660711
61Abnormality of the ileum (HP:0001549)1.92752670
62Abnormality of the metopic suture (HP:0005556)1.91576974
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90988988
64Volvulus (HP:0002580)1.90176976
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.89276652
66Hypoplasia of the fovea (HP:0007750)1.89276652
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.84442658
68Exercise intolerance (HP:0003546)1.84174223
69Lactic acidosis (HP:0003128)1.84013445
70Abnormality of the renal cortex (HP:0011035)1.83998936
71Neoplasm of the adrenal cortex (HP:0100641)1.83697951
72Gaze-evoked nystagmus (HP:0000640)1.82279259
73Hypoglycemic coma (HP:0001325)1.80364622
74Lethargy (HP:0001254)1.78659411
75T lymphocytopenia (HP:0005403)1.76642085
76Dandy-Walker malformation (HP:0001305)1.76048872
77Hypomagnesemia (HP:0002917)1.73314646
78Abolished electroretinogram (ERG) (HP:0000550)1.72998098
79Respiratory difficulties (HP:0002880)1.72982315
80Medial flaring of the eyebrow (HP:0010747)1.72002481
81Clubbing of toes (HP:0100760)1.71316736
82Abnormal hair whorl (HP:0010721)1.70201217
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.69762372
84Oral leukoplakia (HP:0002745)1.69698692
85Abnormality of the musculature of the pelvis (HP:0001469)1.69434868
86Abnormality of the hip-girdle musculature (HP:0001445)1.69434868
87Abnormality of T cell number (HP:0011839)1.69354635
88Increased IgM level (HP:0003496)1.68953319
89Adrenal hypoplasia (HP:0000835)1.67159039
90Horseshoe kidney (HP:0000085)1.66468847
91Abnormality of T cell physiology (HP:0011840)1.65201141
92Hypoglycemic seizures (HP:0002173)1.64559440
93Abnormality of vitamin B metabolism (HP:0004340)1.63479891
94Cellular immunodeficiency (HP:0005374)1.62213387
95Ependymoma (HP:0002888)1.62209935
96Abnormality of T cells (HP:0002843)1.61848448
97Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61659936
98Aplasia/Hypoplasia of the macula (HP:0008059)1.61453073
99Abnormality of the preputium (HP:0100587)1.61414754
100Abnormality of the fovea (HP:0000493)1.61034148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.98481070
2MST44.28927020
3EIF2AK33.23824765
4EIF2AK13.15554333
5MKNK22.97451026
6TRIM282.91077515
7NUAK12.79352467
8FRK2.69130426
9SRPK12.39674838
10PLK32.37878062
11MKNK12.15683626
12ZAK2.13949691
13NEK12.13914236
14PBK1.96529408
15BUB11.95620928
16VRK21.85966745
17TNIK1.81277309
18NME11.76486949
19BMPR1B1.72809599
20EIF2AK21.70128798
21OXSR11.68583529
22TAOK31.65604572
23PLK21.63122068
24ALK1.58089119
25WNK31.57002883
26STK161.53841080
27TAF11.47976461
28STK391.29209136
29NLK1.24500166
30TEC1.22555538
31ACVR1B1.21146228
32VRK11.20141583
33PLK41.17582511
34CDC71.15758524
35ADRBK21.12183345
36TXK1.07224418
37TTK1.02599923
38GRK10.98881341
39PASK0.98433468
40WNK40.93042313
41PIK3CG0.89053097
42PLK10.88817163
43BCR0.87819866
44DYRK20.84621147
45TLK10.82956692
46STK40.82358586
47ATR0.79080291
48PDK20.74559964
49CLK10.73292652
50DYRK30.68949441
51IRAK10.65254726
52IKBKE0.64946637
53TGFBR10.64847491
54PAK30.63790629
55WNK10.61125293
56CSNK1G20.60505672
57CSNK1G10.57608662
58AURKB0.57457191
59WEE10.53818591
60SIK30.52559621
61ATM0.52276759
62CSNK1G30.51499163
63DAPK10.51354993
64PIK3CA0.51110376
65CSNK1A1L0.50840432
66CSNK1E0.49441409
67CSNK2A20.48532956
68ERBB30.47300663
69IKBKB0.43881676
70PHKG20.42880472
71PHKG10.42880472
72BRSK20.41317730
73PRKCE0.40060126
74RPS6KA50.40016037
75JAK30.39814669
76PRKCG0.39404174
77CSNK2A10.38902489
78ITK0.37370380
79PAK40.37305741
80TIE10.37012953
81MAP3K120.35645032
82FGFR10.35351201
83STK110.35240101
84GRK50.35063388
85ADRBK10.32214652
86EGFR0.31415210
87SGK20.31345177
88MAP2K60.30727103
89CHEK20.30689392
90MAP4K20.29462982
91CHEK10.29265411
92CDK80.27898911
93STK30.27452784
94AKT30.26927324
95RPS6KA40.26902996
96DAPK20.26222658
97CSNK1D0.26203094
98STK100.25238125
99TGFBR20.24794766
100PNCK0.22082825

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.45060931
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33340995
3RNA polymerase_Homo sapiens_hsa030203.14993931
4Protein export_Homo sapiens_hsa030603.11034283
5Basal transcription factors_Homo sapiens_hsa030222.83584595
6RNA degradation_Homo sapiens_hsa030182.68804815
7One carbon pool by folate_Homo sapiens_hsa006702.61231769
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55803245
9RNA transport_Homo sapiens_hsa030132.44481395
10Mismatch repair_Homo sapiens_hsa034302.28091970
11Non-homologous end-joining_Homo sapiens_hsa034502.15166523
12Oxidative phosphorylation_Homo sapiens_hsa001902.08424221
13Spliceosome_Homo sapiens_hsa030402.08098694
14Parkinsons disease_Homo sapiens_hsa050122.04867226
15Homologous recombination_Homo sapiens_hsa034402.04571000
16Asthma_Homo sapiens_hsa053102.03836890
17Vitamin B6 metabolism_Homo sapiens_hsa007501.99298635
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88779836
19Allograft rejection_Homo sapiens_hsa053301.84108708
20Propanoate metabolism_Homo sapiens_hsa006401.81917113
21DNA replication_Homo sapiens_hsa030301.69316365
22Pyrimidine metabolism_Homo sapiens_hsa002401.50747361
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.49821422
24Autoimmune thyroid disease_Homo sapiens_hsa053201.49277384
25Huntingtons disease_Homo sapiens_hsa050161.48073993
26Phototransduction_Homo sapiens_hsa047441.44928989
27Nucleotide excision repair_Homo sapiens_hsa034201.38347003
28Fanconi anemia pathway_Homo sapiens_hsa034601.31664470
29Type I diabetes mellitus_Homo sapiens_hsa049401.30921401
30Ribosome_Homo sapiens_hsa030101.30684626
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24150463
32Purine metabolism_Homo sapiens_hsa002301.23983851
33Alzheimers disease_Homo sapiens_hsa050101.23090136
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22600481
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18930615
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.14139942
37Regulation of autophagy_Homo sapiens_hsa041401.13291399
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12278467
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07978024
40p53 signaling pathway_Homo sapiens_hsa041151.00006191
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99880233
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99191601
43Linoleic acid metabolism_Homo sapiens_hsa005910.97406647
44Butanoate metabolism_Homo sapiens_hsa006500.95734223
45mRNA surveillance pathway_Homo sapiens_hsa030150.94522691
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93442906
47Cell cycle_Homo sapiens_hsa041100.92789133
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85338797
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85282562
50Measles_Homo sapiens_hsa051620.84152993
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82250528
52Primary immunodeficiency_Homo sapiens_hsa053400.81955910
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.76948305
54Epstein-Barr virus infection_Homo sapiens_hsa051690.75673400
55Nitrogen metabolism_Homo sapiens_hsa009100.72729389
56Pyruvate metabolism_Homo sapiens_hsa006200.68017642
57Graft-versus-host disease_Homo sapiens_hsa053320.67835017
58Base excision repair_Homo sapiens_hsa034100.63630611
59Selenocompound metabolism_Homo sapiens_hsa004500.61632237
60Ether lipid metabolism_Homo sapiens_hsa005650.59033231
61T cell receptor signaling pathway_Homo sapiens_hsa046600.58024704
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56132654
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.55902411
64TGF-beta signaling pathway_Homo sapiens_hsa043500.55677453
65Hematopoietic cell lineage_Homo sapiens_hsa046400.55079403
66Caffeine metabolism_Homo sapiens_hsa002320.53093166
67Peroxisome_Homo sapiens_hsa041460.52892916
68Sulfur metabolism_Homo sapiens_hsa009200.52762275
69Legionellosis_Homo sapiens_hsa051340.49460467
70Oocyte meiosis_Homo sapiens_hsa041140.45738424
71Metabolic pathways_Homo sapiens_hsa011000.43704456
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42191707
73Olfactory transduction_Homo sapiens_hsa047400.41245455
74Steroid biosynthesis_Homo sapiens_hsa001000.41109024
75Circadian rhythm_Homo sapiens_hsa047100.41025242
76Tryptophan metabolism_Homo sapiens_hsa003800.40060920
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.39869538
78beta-Alanine metabolism_Homo sapiens_hsa004100.39611292
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39568477
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38147751
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.35570662
82Folate biosynthesis_Homo sapiens_hsa007900.34999860
83Arachidonic acid metabolism_Homo sapiens_hsa005900.30722728
84Systemic lupus erythematosus_Homo sapiens_hsa053220.28253695
85Fat digestion and absorption_Homo sapiens_hsa049750.27910854
86Herpes simplex infection_Homo sapiens_hsa051680.27877566
87Rheumatoid arthritis_Homo sapiens_hsa053230.26857180
88Taste transduction_Homo sapiens_hsa047420.26831475
89Antigen processing and presentation_Homo sapiens_hsa046120.24089454
90Carbon metabolism_Homo sapiens_hsa012000.22994859
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21502577
92Glutathione metabolism_Homo sapiens_hsa004800.17803277
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16728793
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.14796940
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14614759
96Cardiac muscle contraction_Homo sapiens_hsa042600.13985170
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13604646
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12578966
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11884739
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11591499

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