NPM1P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)5.68240689
2rRNA modification (GO:0000154)5.56265839
3proteasome assembly (GO:0043248)5.06240353
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.79912005
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.74751199
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.74751199
7folic acid-containing compound biosynthetic process (GO:0009396)4.66157461
8IMP biosynthetic process (GO:0006188)4.35744208
9chaperone-mediated protein transport (GO:0072321)4.30124401
10regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.28186046
11ribosome biogenesis (GO:0042254)4.27244682
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.22807589
13DNA deamination (GO:0045006)4.11719187
14ribosomal small subunit assembly (GO:0000028)4.08730492
15pseudouridine synthesis (GO:0001522)4.07846865
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.05187424
17rRNA processing (GO:0006364)3.99972253
18GTP biosynthetic process (GO:0006183)3.96149067
19mitochondrial RNA metabolic process (GO:0000959)3.94876035
20ATP synthesis coupled proton transport (GO:0015986)3.93886643
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93886643
22ribosome assembly (GO:0042255)3.93586100
23CENP-A containing nucleosome assembly (GO:0034080)3.92730230
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.91431657
25regulation of immunoglobulin secretion (GO:0051023)3.84877854
26rRNA metabolic process (GO:0016072)3.84096256
27chromatin remodeling at centromere (GO:0031055)3.83931541
28ribosomal large subunit biogenesis (GO:0042273)3.82920445
29ribonucleoprotein complex biogenesis (GO:0022613)3.81042808
30maturation of SSU-rRNA (GO:0030490)3.80952390
31IMP metabolic process (GO:0046040)3.79243226
32maturation of 5.8S rRNA (GO:0000460)3.78164778
33pteridine-containing compound biosynthetic process (GO:0042559)3.76018243
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74804186
35regulation of isotype switching to IgG isotypes (GO:0048302)3.67713919
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66556638
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62737511
38purine nucleotide salvage (GO:0032261)3.57860876
39cellular component biogenesis (GO:0044085)3.51133141
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50888200
41UTP biosynthetic process (GO:0006228)3.49419099
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47861375
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47861375
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47861375
45termination of RNA polymerase I transcription (GO:0006363)3.47380324
46transcription elongation from RNA polymerase I promoter (GO:0006362)3.44634516
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43952542
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43952542
49regulation of cellular amino acid metabolic process (GO:0006521)3.42574229
50UTP metabolic process (GO:0046051)3.42213778
51termination of RNA polymerase III transcription (GO:0006386)3.42128542
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.42128542
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40312874
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.38007663
55isotype switching (GO:0045190)3.38007663
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.38007663
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36044912
58signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35407398
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.35407398
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.30442599
61histone exchange (GO:0043486)3.30216100
62guanosine-containing compound biosynthetic process (GO:1901070)3.28294495
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.27363380
64NADH dehydrogenase complex assembly (GO:0010257)3.27363380
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27363380
66positive regulation of isotype switching (GO:0045830)3.26471681
67negative regulation of ligase activity (GO:0051352)3.24055673
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24055673
69protein complex biogenesis (GO:0070271)3.23819128
70CTP biosynthetic process (GO:0006241)3.22693522
71CTP metabolic process (GO:0046036)3.22693522
72mitochondrial respiratory chain complex assembly (GO:0033108)3.19562788
73transcription from mitochondrial promoter (GO:0006390)3.18471577
74behavioral response to nicotine (GO:0035095)3.17834760
75peptidyl-histidine modification (GO:0018202)3.17321705
76protein targeting to mitochondrion (GO:0006626)3.16476748
77translation (GO:0006412)3.16154939
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15723789
79ncRNA processing (GO:0034470)3.10363349
80protein-cofactor linkage (GO:0018065)3.09767455
81DNA double-strand break processing (GO:0000729)3.08565544
82positive regulation of DNA recombination (GO:0045911)3.08273653
83amino acid salvage (GO:0043102)3.06358513
84L-methionine salvage (GO:0071267)3.06358513
85L-methionine biosynthetic process (GO:0071265)3.06358513
86tRNA processing (GO:0008033)3.05651433
87spliceosomal snRNP assembly (GO:0000387)3.04919691
88ncRNA metabolic process (GO:0034660)3.04578496
89DNA replication checkpoint (GO:0000076)3.03765988
90regulation of chronic inflammatory response (GO:0002676)3.03556519
91protein localization to mitochondrion (GO:0070585)3.02275988
92purine nucleobase biosynthetic process (GO:0009113)3.00469762
93water-soluble vitamin biosynthetic process (GO:0042364)3.00184067
94tRNA metabolic process (GO:0006399)2.98374834
95amino acid activation (GO:0043038)2.98035212
96tRNA aminoacylation (GO:0043039)2.98035212
97nucleobase biosynthetic process (GO:0046112)2.96236050
98tetrahydrofolate metabolic process (GO:0046653)2.96097539
99DNA replication-independent nucleosome organization (GO:0034724)2.94628217
100DNA replication-independent nucleosome assembly (GO:0006336)2.94628217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.97791038
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.02835677
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.86138397
4E2F7_22180533_ChIP-Seq_HELA_Human4.49863900
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.09221891
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.74809356
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41691071
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14446889
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.05476511
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04567027
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96402050
12VDR_23849224_ChIP-Seq_CD4+_Human2.85756932
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72949096
14ELK1_19687146_ChIP-ChIP_HELA_Human2.61968463
15FOXP3_21729870_ChIP-Seq_TREG_Human2.49891675
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41247896
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38150935
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37855093
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31545793
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30757874
21VDR_22108803_ChIP-Seq_LS180_Human2.30650026
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.11967870
23TTF2_22483619_ChIP-Seq_HELA_Human2.02381356
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99267502
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97779327
26DCP1A_22483619_ChIP-Seq_HELA_Human1.94953176
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90940737
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90076699
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89487784
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.88960729
31ZNF274_21170338_ChIP-Seq_K562_Hela1.86403934
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85980767
33EWS_26573619_Chip-Seq_HEK293_Human1.85968096
34GABP_19822575_ChIP-Seq_HepG2_Human1.85064532
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79147224
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77353897
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76410381
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72019445
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.64117179
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58857545
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54410231
42XRN2_22483619_ChIP-Seq_HELA_Human1.52431299
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49718306
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.46583080
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43502069
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43007432
47TP53_22573176_ChIP-Seq_HFKS_Human1.42531421
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38556243
49MYC_18940864_ChIP-ChIP_HL60_Human1.38128674
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35648236
51ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29345139
52AR_21909140_ChIP-Seq_LNCAP_Human1.29125577
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28802602
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26005312
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25252952
56FUS_26573619_Chip-Seq_HEK293_Human1.20488660
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18841271
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14098263
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14021169
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07891231
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07853394
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06512395
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04019163
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.03900656
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03557095
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02698686
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02174994
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.01762955
69FOXM1_23109430_ChIP-Seq_U2OS_Human0.98204727
70CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97434564
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92784017
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92458025
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89626569
74P300_19829295_ChIP-Seq_ESCs_Human0.88053446
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88026272
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85978880
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85958145
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85293896
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83093509
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82192974
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.82192974
82KDM5A_27292631_Chip-Seq_BREAST_Human0.81905078
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.79814106
84NCOR_22424771_ChIP-Seq_293T_Human0.77722021
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77689433
86HOXB7_26014856_ChIP-Seq_BT474_Human0.76737951
87ERG_20517297_ChIP-Seq_VCAP_Human0.76395888
88EZH2_22144423_ChIP-Seq_EOC_Human0.73819329
89NANOG_19829295_ChIP-Seq_ESCs_Human0.73794123
90SOX2_19829295_ChIP-Seq_ESCs_Human0.73794123
91GATA3_26560356_Chip-Seq_TH1_Human0.73431778
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.73215613
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72875452
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72865014
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.72572497
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71020701
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70809455
98GATA3_26560356_Chip-Seq_TH2_Human0.70296803
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.69569479
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69390405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.83594227
2MP0006292_abnormal_olfactory_placode3.52286562
3MP0008058_abnormal_DNA_repair3.24742248
4MP0001835_abnormal_antigen_presentation3.07572010
5MP0010094_abnormal_chromosome_stability2.89456966
6MP0002102_abnormal_ear_morphology2.67068146
7MP0004957_abnormal_blastocyst_morpholog2.52315882
8MP0003786_premature_aging2.48830175
9MP0003693_abnormal_embryo_hatching2.48262501
10MP0008872_abnormal_physiological_respon2.27250245
11MP0003806_abnormal_nucleotide_metabolis2.26240191
12MP0002938_white_spotting2.21512174
13MP0003718_maternal_effect2.09772821
14MP0004147_increased_porphyrin_level2.01707675
15MP0005670_abnormal_white_adipose2.00562986
16MP0006072_abnormal_retinal_apoptosis1.96236454
17MP0003186_abnormal_redox_activity1.94452357
18MP0008877_abnormal_DNA_methylation1.91576913
19MP0003878_abnormal_ear_physiology1.88907810
20MP0005377_hearing/vestibular/ear_phenot1.88907810
21MP0003111_abnormal_nucleus_morphology1.85405727
22MP0002736_abnormal_nociception_after1.83319635
23MP0003077_abnormal_cell_cycle1.81192448
24MP0008875_abnormal_xenobiotic_pharmacok1.72322006
25MP0000685_abnormal_immune_system1.72038979
26MP0002006_tumorigenesis1.62012536
27MP0008057_abnormal_DNA_replication1.60824364
28MP0002234_abnormal_pharynx_morphology1.56659678
29MP0008995_early_reproductive_senescence1.55838262
30MP0003567_abnormal_fetal_cardiomyocyte1.53112315
31MP0001293_anophthalmia1.52553622
32MP0005551_abnormal_eye_electrophysiolog1.52382266
33MP0002396_abnormal_hematopoietic_system1.49724994
34MP0005645_abnormal_hypothalamus_physiol1.49083038
35MP0001661_extended_life_span1.45109298
36MP0005360_urolithiasis1.44700446
37MP0001348_abnormal_lacrimal_gland1.41957856
38MP0008789_abnormal_olfactory_epithelium1.41601118
39MP0004885_abnormal_endolymph1.41412399
40MP0008007_abnormal_cellular_replicative1.39416286
41MP0009697_abnormal_copulation1.38764759
42MP0005646_abnormal_pituitary_gland1.35461810
43MP0001529_abnormal_vocalization1.34578643
44MP0001873_stomach_inflammation1.33597242
45MP0009333_abnormal_splenocyte_physiolog1.32058200
46MP0001853_heart_inflammation1.31182969
47MP0003183_abnormal_peptide_metabolism1.31043509
48MP0002837_dystrophic_cardiac_calcinosis1.30017951
49MP0001968_abnormal_touch/_nociception1.29342010
50MP0006036_abnormal_mitochondrial_physio1.27689271
51MP0002166_altered_tumor_susceptibility1.26604648
52MP0005671_abnormal_response_to1.26083842
53MP0001188_hyperpigmentation1.25884319
54MP0002163_abnormal_gland_morphology1.22977131
55MP0002095_abnormal_skin_pigmentation1.18776255
56MP0004142_abnormal_muscle_tone1.18378470
57MP0005084_abnormal_gallbladder_morpholo1.15350102
58MP0000372_irregular_coat_pigmentation1.14855077
59MP0004145_abnormal_muscle_electrophysio1.13186115
60MP0005332_abnormal_amino_acid1.12291631
61MP0005408_hypopigmentation1.10013077
62MP0002160_abnormal_reproductive_system1.09842055
63MP0002138_abnormal_hepatobiliary_system1.07966331
64MP0002210_abnormal_sex_determination1.05578196
65MP0006035_abnormal_mitochondrial_morpho1.04825958
66MP0001800_abnormal_humoral_immune1.04226579
67MP0005075_abnormal_melanosome_morpholog1.02166540
68MP0005174_abnormal_tail_pigmentation1.01608475
69MP0003646_muscle_fatigue1.01137143
70MP0005253_abnormal_eye_physiology0.98897495
71MP0005389_reproductive_system_phenotype0.96016461
72MP0005410_abnormal_fertilization0.93815600
73MP0008932_abnormal_embryonic_tissue0.91774718
74MP0005394_taste/olfaction_phenotype0.90494657
75MP0005499_abnormal_olfactory_system0.90494657
76MP0000631_abnormal_neuroendocrine_gland0.89310201
77MP0001986_abnormal_taste_sensitivity0.87451321
78MP0001929_abnormal_gametogenesis0.86993323
79MP0005387_immune_system_phenotype0.85543630
80MP0001790_abnormal_immune_system0.85543630
81MP0000427_abnormal_hair_cycle0.84350432
82MP0002148_abnormal_hypersensitivity_rea0.83760113
83MP0001502_abnormal_circadian_rhythm0.82762146
84MP0000653_abnormal_sex_gland0.80777928
85MP0002272_abnormal_nervous_system0.79531776
86MP0001764_abnormal_homeostasis0.78218602
87MP0001905_abnormal_dopamine_level0.77029263
88MP0003195_calcinosis0.76943105
89MP0009785_altered_susceptibility_to0.75233619
90MP0001145_abnormal_male_reproductive0.75151296
91MP0005379_endocrine/exocrine_gland_phen0.73957555
92MP0001919_abnormal_reproductive_system0.73926674
93MP0001119_abnormal_female_reproductive0.72388139
94MP0005636_abnormal_mineral_homeostasis0.72086136
95MP0002019_abnormal_tumor_incidence0.69088726
96MP0001501_abnormal_sleep_pattern0.67920661
97MP0003011_delayed_dark_adaptation0.66573939
98MP0006276_abnormal_autonomic_nervous0.65715349
99MP0005085_abnormal_gallbladder_physiolo0.65477863
100MP0003937_abnormal_limbs/digits/tail_de0.65070356

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.51876114
2Hyperalaninemia (HP:0003348)4.51876114
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.51876114
4Acute necrotizing encephalopathy (HP:0006965)4.19475941
5Stomatitis (HP:0010280)3.77038438
6Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.76098201
7Acute encephalopathy (HP:0006846)3.63141036
8Increased CSF lactate (HP:0002490)3.49293507
9Mitochondrial inheritance (HP:0001427)3.47768262
10Abnormal mitochondria in muscle tissue (HP:0008316)3.40236202
11Increased hepatocellular lipid droplets (HP:0006565)3.39008204
12Progressive macrocephaly (HP:0004481)3.38816498
13Abnormality of the labia minora (HP:0012880)3.34682756
14Constricted visual fields (HP:0001133)3.27692778
15Increased serum lactate (HP:0002151)3.10929870
16Lipid accumulation in hepatocytes (HP:0006561)3.09119342
17Congenital, generalized hypertrichosis (HP:0004540)3.04347744
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02410518
193-Methylglutaconic aciduria (HP:0003535)3.00701629
20Cerebral edema (HP:0002181)2.98738319
21Abnormality of the pons (HP:0007361)2.93611223
22Hepatocellular necrosis (HP:0001404)2.90538218
23Colon cancer (HP:0003003)2.87174266
24IgG deficiency (HP:0004315)2.83832555
25Reticulocytopenia (HP:0001896)2.82234102
26Renal Fanconi syndrome (HP:0001994)2.74659952
27Meckel diverticulum (HP:0002245)2.66241515
28Congenital stationary night blindness (HP:0007642)2.60206588
29Hepatic necrosis (HP:0002605)2.57326206
30Macrocytic anemia (HP:0001972)2.55571314
31Abnormality of serum amino acid levels (HP:0003112)2.55117674
32Optic disc pallor (HP:0000543)2.53617439
33Oligodactyly (hands) (HP:0001180)2.53614275
34Fatigue (HP:0012378)2.52476826
35Abnormality of the ileum (HP:0001549)2.50441738
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50277716
37Duplicated collecting system (HP:0000081)2.47034724
38Horseshoe kidney (HP:0000085)2.46430280
39Lactic acidosis (HP:0003128)2.43991750
40Pancreatic cysts (HP:0001737)2.40167620
41Exertional dyspnea (HP:0002875)2.39138300
42Pendular nystagmus (HP:0012043)2.38704781
43Abnormality of midbrain morphology (HP:0002418)2.37591474
44Molar tooth sign on MRI (HP:0002419)2.37591474
45Hypoplasia of the pons (HP:0012110)2.35189309
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.29729097
47Elevated erythrocyte sedimentation rate (HP:0003565)2.26139679
48Abnormality of the renal collecting system (HP:0004742)2.25780382
49Exercise intolerance (HP:0003546)2.23699354
50Absent thumb (HP:0009777)2.22450414
51Megaloblastic anemia (HP:0001889)2.19980288
52Leukodystrophy (HP:0002415)2.17478842
53Homocystinuria (HP:0002156)2.17131092
54Abnormality of homocysteine metabolism (HP:0010919)2.17131092
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15095905
56Chronic sinusitis (HP:0011109)2.14847491
57Multiple enchondromatosis (HP:0005701)2.13374018
58Supernumerary spleens (HP:0009799)2.10964378
59Abnormality of methionine metabolism (HP:0010901)2.08748851
60Abnormality of the preputium (HP:0100587)2.07628319
61Stenosis of the external auditory canal (HP:0000402)2.05872298
62Methylmalonic acidemia (HP:0002912)2.04906966
63Cerebral hypomyelination (HP:0006808)2.04886995
64Nephronophthisis (HP:0000090)2.02935941
65Lethargy (HP:0001254)2.02698478
66Increased IgM level (HP:0003496)2.00364495
67Birth length less than 3rd percentile (HP:0003561)2.00332408
68Abnormality of sulfur amino acid metabolism (HP:0004339)1.97912710
69Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97307625
70Triphalangeal thumb (HP:0001199)1.95265729
71Oligodactyly (HP:0012165)1.93199188
72Abnormality of chromosome stability (HP:0003220)1.92814508
73Abnormality of the renal cortex (HP:0011035)1.92692773
74Ectopic kidney (HP:0000086)1.91706188
75Premature ovarian failure (HP:0008209)1.90439928
76Chromsome breakage (HP:0040012)1.89660039
77Duodenal stenosis (HP:0100867)1.88514738
78Small intestinal stenosis (HP:0012848)1.88514738
79Paralysis (HP:0003470)1.86651429
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86146383
81Abnormal respiratory motile cilium morphology (HP:0005938)1.85027055
82Abnormal respiratory epithelium morphology (HP:0012253)1.85027055
83Abnormal rod and cone electroretinograms (HP:0008323)1.80828599
84Tubular atrophy (HP:0000092)1.79856484
85Oral leukoplakia (HP:0002745)1.79709697
86Type II lissencephaly (HP:0007260)1.78945141
87Hyperglycinemia (HP:0002154)1.78722773
88Abolished electroretinogram (ERG) (HP:0000550)1.78658924
89Congenital sensorineural hearing impairment (HP:0008527)1.77915356
90Myelodysplasia (HP:0002863)1.77413367
91Abnormality of cells of the erythroid lineage (HP:0012130)1.77349987
92Anorexia (HP:0002039)1.77098070
93Hyperglycinuria (HP:0003108)1.76207554
94Absent septum pellucidum (HP:0001331)1.74650818
95Cleft eyelid (HP:0000625)1.74099415
96Clubbing of toes (HP:0100760)1.73831248
97Abnormal number of erythroid precursors (HP:0012131)1.73619182
98Respiratory failure (HP:0002878)1.73591803
99Cortical visual impairment (HP:0100704)1.72960263
100Abnormal lung lobation (HP:0002101)1.72755190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.56563143
2MST44.23048297
3VRK23.18427557
4EIF2AK12.96113313
5EIF2AK32.91792501
6SRPK12.74963657
7ZAK2.54479767
8TRIM282.46427450
9WNK42.38546739
10PBK2.30682464
11BUB12.17232487
12PLK32.16797317
13NUAK12.13512202
14NME12.13430389
15TAF12.06282579
16VRK11.95751084
17MKNK21.95624945
18CDC71.90038886
19STK391.87217606
20NEK11.74309590
21PLK41.73921846
22WNK31.60491560
23MKNK11.55057656
24EIF2AK21.52041349
25TNIK1.49550617
26ALK1.45594301
27GRK11.43497345
28TEC1.42530344
29BMPR1B1.39387337
30ADRBK21.37086201
31ACVR1B1.31012806
32MAP2K61.28887932
33TLK11.26353041
34TTK1.22885253
35OXSR11.20815930
36BMPR21.20199664
37TXK1.18219660
38DYRK21.12693958
39PLK11.05541394
40ATR0.98969188
41WEE10.94905954
42PASK0.93066859
43CDK70.90832875
44CHEK20.90412967
45TGFBR10.86450655
46MAP3K40.84722484
47PLK20.83959170
48PIK3CG0.82077604
49RPS6KA40.82063290
50RPS6KB20.81837967
51STK40.77603348
52AURKB0.75497160
53IKBKB0.73442661
54CCNB10.72280386
55FGFR10.70439723
56NME20.68554699
57BCKDK0.67767784
58CDK90.66849661
59MAP2K70.65941107
60STK160.64585449
61DYRK30.62525545
62AKT30.62055718
63RPS6KA50.61241769
64JAK30.59988041
65CSNK2A20.59848758
66DAPK30.54262600
67CHEK10.53779998
68CSNK2A10.53537702
69ITK0.51351748
70WNK10.50246826
71CSNK1E0.47267226
72ADRBK10.46208629
73PRKCG0.41715539
74DAPK10.41593461
75KIT0.41537827
76FLT30.41437593
77TIE10.40933012
78CSNK1A10.39705987
79ATM0.39616363
80BRD40.38518745
81AURKA0.35517210
82PDK20.33882995
83CSNK1G30.32902544
84PRKCE0.32497668
85INSRR0.31253435
86CSNK1G10.30963749
87PIM20.30753562
88PRKCQ0.29888426
89CSNK1G20.25966853
90STK30.25593256
91PHKG20.25359347
92PHKG10.25359347
93CDK60.23793559
94EPHB20.23750042
95MAP2K30.22391475
96PRKCI0.22176673
97CLK10.22101893
98FGR0.22081329
99CDK10.20596554
100PAK40.20525841

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.77577058
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58925820
3Ribosome_Homo sapiens_hsa030103.40624562
4One carbon pool by folate_Homo sapiens_hsa006703.03522881
5Protein export_Homo sapiens_hsa030602.96882196
6RNA polymerase_Homo sapiens_hsa030202.91094480
7Oxidative phosphorylation_Homo sapiens_hsa001902.89861893
8Asthma_Homo sapiens_hsa053102.70036842
9Mismatch repair_Homo sapiens_hsa034302.62296981
10DNA replication_Homo sapiens_hsa030302.31940589
11Parkinsons disease_Homo sapiens_hsa050122.31670546
12RNA degradation_Homo sapiens_hsa030182.29645793
13Basal transcription factors_Homo sapiens_hsa030222.28693243
14Homologous recombination_Homo sapiens_hsa034402.13017088
15RNA transport_Homo sapiens_hsa030132.04612030
16Spliceosome_Homo sapiens_hsa030402.04370082
17Allograft rejection_Homo sapiens_hsa053301.96887387
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96398227
19Autoimmune thyroid disease_Homo sapiens_hsa053201.84293581
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.75588648
21Propanoate metabolism_Homo sapiens_hsa006401.73558524
22Huntingtons disease_Homo sapiens_hsa050161.72676420
23Nucleotide excision repair_Homo sapiens_hsa034201.68979916
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.67320067
25Vitamin B6 metabolism_Homo sapiens_hsa007501.56013313
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43986508
27Pyrimidine metabolism_Homo sapiens_hsa002401.42616671
28Fanconi anemia pathway_Homo sapiens_hsa034601.41410882
29Base excision repair_Homo sapiens_hsa034101.40621559
30Alzheimers disease_Homo sapiens_hsa050101.39968938
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27728787
32Non-homologous end-joining_Homo sapiens_hsa034501.27300627
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22322175
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18650614
35Collecting duct acid secretion_Homo sapiens_hsa049661.16974901
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16551362
37Purine metabolism_Homo sapiens_hsa002301.13079047
38Primary immunodeficiency_Homo sapiens_hsa053401.12300810
39Type I diabetes mellitus_Homo sapiens_hsa049401.09827084
40Sulfur metabolism_Homo sapiens_hsa009201.05798316
41Graft-versus-host disease_Homo sapiens_hsa053321.00662864
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98138839
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95001450
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91511659
45Linoleic acid metabolism_Homo sapiens_hsa005910.88734774
46mRNA surveillance pathway_Homo sapiens_hsa030150.88393841
47Cardiac muscle contraction_Homo sapiens_hsa042600.86807354
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85533231
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77581123
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76898763
51Arginine biosynthesis_Homo sapiens_hsa002200.74239436
52Selenocompound metabolism_Homo sapiens_hsa004500.65027012
53Peroxisome_Homo sapiens_hsa041460.63586135
54Phototransduction_Homo sapiens_hsa047440.63528385
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63059013
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60835893
57Pyruvate metabolism_Homo sapiens_hsa006200.60502002
58Cell cycle_Homo sapiens_hsa041100.58074001
59Antigen processing and presentation_Homo sapiens_hsa046120.57878452
60Metabolic pathways_Homo sapiens_hsa011000.57393637
61Folate biosynthesis_Homo sapiens_hsa007900.57059023
62Nitrogen metabolism_Homo sapiens_hsa009100.55475968
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.54716199
64Epstein-Barr virus infection_Homo sapiens_hsa051690.54239343
65Rheumatoid arthritis_Homo sapiens_hsa053230.53392329
66Tryptophan metabolism_Homo sapiens_hsa003800.52053514
67Hematopoietic cell lineage_Homo sapiens_hsa046400.48563611
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47252018
69Biosynthesis of amino acids_Homo sapiens_hsa012300.45414531
70Butanoate metabolism_Homo sapiens_hsa006500.43295716
71Olfactory transduction_Homo sapiens_hsa047400.43179465
72Caffeine metabolism_Homo sapiens_hsa002320.42823059
73beta-Alanine metabolism_Homo sapiens_hsa004100.42657511
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40576435
75Vitamin digestion and absorption_Homo sapiens_hsa049770.38386062
76Glutathione metabolism_Homo sapiens_hsa004800.38281577
77Retinol metabolism_Homo sapiens_hsa008300.38103744
78Ether lipid metabolism_Homo sapiens_hsa005650.37036693
79Regulation of autophagy_Homo sapiens_hsa041400.35604231
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34268364
81Carbon metabolism_Homo sapiens_hsa012000.33785073
82Arachidonic acid metabolism_Homo sapiens_hsa005900.32223427
83Systemic lupus erythematosus_Homo sapiens_hsa053220.30803832
84Nicotine addiction_Homo sapiens_hsa050330.29741428
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29591643
86Sulfur relay system_Homo sapiens_hsa041220.27914899
87Arginine and proline metabolism_Homo sapiens_hsa003300.27478772
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26124294
89T cell receptor signaling pathway_Homo sapiens_hsa046600.25334989
90GABAergic synapse_Homo sapiens_hsa047270.23971023
91p53 signaling pathway_Homo sapiens_hsa041150.23206699
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23201949
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.22565738
94Morphine addiction_Homo sapiens_hsa050320.22130188
95Fatty acid degradation_Homo sapiens_hsa000710.19929879
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.19595728
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19364844
98Measles_Homo sapiens_hsa051620.19144156
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18304806
100Fatty acid biosynthesis_Homo sapiens_hsa000610.17948172

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »