NPM1P32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.93174275
2rRNA methylation (GO:0031167)5.78248818
3rRNA modification (GO:0000154)5.73534553
4DNA deamination (GO:0045006)5.25168931
5regulation of isotype switching to IgG isotypes (GO:0048302)4.48389589
6cullin deneddylation (GO:0010388)4.14230460
7protein-cofactor linkage (GO:0018065)4.08781054
8maturation of 5.8S rRNA (GO:0000460)4.02681010
9signal peptide processing (GO:0006465)3.97088942
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.92289928
11chaperone-mediated protein transport (GO:0072321)3.85560224
12protein deneddylation (GO:0000338)3.82467180
13protein neddylation (GO:0045116)3.78493241
14dopamine transport (GO:0015872)3.68882275
15termination of RNA polymerase I transcription (GO:0006363)3.66893319
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.55919213
17transcription elongation from RNA polymerase I promoter (GO:0006362)3.54882157
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47247443
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46312452
20respiratory chain complex IV assembly (GO:0008535)3.43858981
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40380706
22positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.37087324
23ribosome assembly (GO:0042255)3.35060946
24adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34842799
25regulation of chronic inflammatory response (GO:0002676)3.30288483
26regulation of cellular amino acid metabolic process (GO:0006521)3.28246873
27mitochondrial respiratory chain complex assembly (GO:0033108)3.25967145
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23310993
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23310993
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23310993
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23066561
32water-soluble vitamin biosynthetic process (GO:0042364)3.22759028
33DNA double-strand break processing (GO:0000729)3.22320810
34ribosomal large subunit biogenesis (GO:0042273)3.22142951
35chromatin remodeling at centromere (GO:0031055)3.20548738
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.20480691
37somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.20480691
38isotype switching (GO:0045190)3.20480691
39negative regulation of cAMP-mediated signaling (GO:0043951)3.19668480
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.18500524
41regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18399238
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15342990
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15342990
44DNA damage response, detection of DNA damage (GO:0042769)3.14698667
45CENP-A containing nucleosome assembly (GO:0034080)3.11291384
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10164608
47transcription initiation from RNA polymerase I promoter (GO:0006361)3.09897154
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.08213413
49termination of RNA polymerase III transcription (GO:0006386)3.08213413
50histone mRNA metabolic process (GO:0008334)3.08172092
51regulation of immunoglobulin secretion (GO:0051023)3.08146159
52protein complex biogenesis (GO:0070271)3.07676691
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07398765
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.05731013
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03243968
56ATP synthesis coupled proton transport (GO:0015986)3.03243968
57signal transduction involved in DNA damage checkpoint (GO:0072422)3.02897553
58signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02897553
59cytidine deamination (GO:0009972)3.01131316
60cytidine metabolic process (GO:0046087)3.01131316
61cytidine catabolic process (GO:0006216)3.01131316
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.00815302
63formation of translation preinitiation complex (GO:0001731)2.99889982
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99282776
65negative regulation of ligase activity (GO:0051352)2.99282776
66auditory receptor cell stereocilium organization (GO:0060088)2.98083968
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97634575
68peristalsis (GO:0030432)2.95984440
69protein targeting to mitochondrion (GO:0006626)2.94722364
70regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93894118
71regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93894118
72DNA catabolic process, exonucleolytic (GO:0000738)2.91449609
73rRNA processing (GO:0006364)2.85108960
74transcription from RNA polymerase I promoter (GO:0006360)2.82484549
75protein localization to mitochondrion (GO:0070585)2.79619870
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79109814
77DNA replication checkpoint (GO:0000076)2.78904976
787-methylguanosine mRNA capping (GO:0006370)2.78372985
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77118743
80histone exchange (GO:0043486)2.77101065
81response to pheromone (GO:0019236)2.75602506
82replication fork processing (GO:0031297)2.74915794
83rRNA metabolic process (GO:0016072)2.73845388
84cytochrome complex assembly (GO:0017004)2.72801910
85RNA capping (GO:0036260)2.71877493
867-methylguanosine RNA capping (GO:0009452)2.71877493
87negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.70569880
88centriole replication (GO:0007099)2.69506242
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68435539
90establishment of protein localization to mitochondrion (GO:0072655)2.67095703
91positive regulation of ligase activity (GO:0051351)2.65745763
92regulation of regulatory T cell differentiation (GO:0045589)2.63816324
93spliceosomal snRNP assembly (GO:0000387)2.63632584
94translation (GO:0006412)2.62355794
95sulfation (GO:0051923)2.62130560
96pseudouridine synthesis (GO:0001522)2.60478536
97ribosomal small subunit assembly (GO:0000028)2.59743599
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58260903
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.58260903
100NADH dehydrogenase complex assembly (GO:0010257)2.58260903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.98397737
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30894402
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.00742242
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.62785402
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40421692
6ZNF274_21170338_ChIP-Seq_K562_Hela3.01839506
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87636642
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.74475387
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67461402
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67199856
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57694716
12VDR_23849224_ChIP-Seq_CD4+_Human2.47762853
13ELK1_19687146_ChIP-ChIP_HELA_Human2.42635998
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40907164
15EWS_26573619_Chip-Seq_HEK293_Human2.31969933
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.31962103
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29943271
18VDR_22108803_ChIP-Seq_LS180_Human2.27650047
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13956599
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.11571520
21TAF15_26573619_Chip-Seq_HEK293_Human2.09974491
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09543800
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01187059
24FOXP3_21729870_ChIP-Seq_TREG_Human1.97914241
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92562210
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75557171
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.74381387
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71248393
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62945807
30E2F7_22180533_ChIP-Seq_HELA_Human1.58661289
31FUS_26573619_Chip-Seq_HEK293_Human1.58447663
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56822728
33MYC_18940864_ChIP-ChIP_HL60_Human1.53362065
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53130267
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51045461
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48820335
37P300_19829295_ChIP-Seq_ESCs_Human1.48436954
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46060402
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45835253
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.42646507
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36032341
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35783798
43DCP1A_22483619_ChIP-Seq_HELA_Human1.35428736
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34060106
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32703800
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31131369
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.29710186
48TP53_22573176_ChIP-Seq_HFKS_Human1.29518476
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28712340
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26825228
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25896888
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23694675
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23452783
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22844210
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.21504559
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20309352
57TTF2_22483619_ChIP-Seq_HELA_Human1.19774385
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17086351
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17026573
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16927760
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13753879
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.13627678
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.12186437
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12186437
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09890580
66ER_23166858_ChIP-Seq_MCF-7_Human1.08491550
67SOX2_19829295_ChIP-Seq_ESCs_Human1.08409321
68NANOG_19829295_ChIP-Seq_ESCs_Human1.08409321
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06519561
70GABP_19822575_ChIP-Seq_HepG2_Human1.06362751
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05340976
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.04846848
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03767620
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03731004
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01754474
76BCAT_22108803_ChIP-Seq_LS180_Human1.01668325
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.01585647
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99827955
79P300_18555785_Chip-Seq_ESCs_Mouse0.99321061
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99138219
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97598242
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97477616
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95568790
84GATA3_26560356_Chip-Seq_TH2_Human0.95303197
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.94346568
86HTT_18923047_ChIP-ChIP_STHdh_Human0.93282710
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.93224874
88JUN_21703547_ChIP-Seq_K562_Human0.92137009
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.91604916
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90380056
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90275392
92CBP_20019798_ChIP-Seq_JUKART_Human0.89890905
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89890905
94IGF1R_20145208_ChIP-Seq_DFB_Human0.88640003
95HOXB7_26014856_ChIP-Seq_BT474_Human0.87768424
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87768046
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.86985387
98IRF1_19129219_ChIP-ChIP_H3396_Human0.86220431
99CDX2_22108803_ChIP-Seq_LS180_Human0.84834646
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84732743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.02804837
2MP0003880_abnormal_central_pattern4.96850977
3MP0008058_abnormal_DNA_repair3.20571447
4MP0002138_abnormal_hepatobiliary_system3.01186373
5MP0003693_abnormal_embryo_hatching2.76775863
6MP0004957_abnormal_blastocyst_morpholog2.72118433
7MP0002102_abnormal_ear_morphology2.57607720
8MP0001873_stomach_inflammation2.54577829
9MP0010094_abnormal_chromosome_stability2.49855070
10MP0010386_abnormal_urinary_bladder2.29752165
11MP0001835_abnormal_antigen_presentation2.12752615
12MP0005084_abnormal_gallbladder_morpholo2.03566924
13MP0005310_abnormal_salivary_gland2.02148395
14MP0002876_abnormal_thyroid_physiology1.89466894
15MP0001529_abnormal_vocalization1.81868022
16MP0000685_abnormal_immune_system1.80835118
17MP0003718_maternal_effect1.80405802
18MP0001348_abnormal_lacrimal_gland1.66813988
19MP0005085_abnormal_gallbladder_physiolo1.66500357
20MP0005671_abnormal_response_to1.65778601
21MP0001968_abnormal_touch/_nociception1.65486915
22MP0008872_abnormal_physiological_respon1.62851605
23MP0001485_abnormal_pinna_reflex1.61084660
24MP0005410_abnormal_fertilization1.59993153
25MP0005387_immune_system_phenotype1.57316362
26MP0001790_abnormal_immune_system1.57316362
27MP0003077_abnormal_cell_cycle1.57059410
28MP0002277_abnormal_respiratory_mucosa1.55987049
29MP0005408_hypopigmentation1.54122705
30MP0008875_abnormal_xenobiotic_pharmacok1.53176262
31MP0001293_anophthalmia1.47532457
32MP0008877_abnormal_DNA_methylation1.45191707
33MP0002166_altered_tumor_susceptibility1.41983224
34MP0006072_abnormal_retinal_apoptosis1.41763347
35MP0005379_endocrine/exocrine_gland_phen1.39156766
36MP0009333_abnormal_splenocyte_physiolog1.38648949
37MP0001984_abnormal_olfaction1.36160025
38MP0003252_abnormal_bile_duct1.32861420
39MP0004885_abnormal_endolymph1.28511348
40MP0005551_abnormal_eye_electrophysiolog1.27901959
41MP0005075_abnormal_melanosome_morpholog1.25322433
42MP0002006_tumorigenesis1.24091693
43MP0001764_abnormal_homeostasis1.23902614
44MP0008007_abnormal_cellular_replicative1.22889185
45MP0004215_abnormal_myocardial_fiber1.22436685
46MP0003119_abnormal_digestive_system1.18010979
47MP0003786_premature_aging1.18010957
48MP0006036_abnormal_mitochondrial_physio1.12630940
49MP0002928_abnormal_bile_duct1.09990764
50MP0000372_irregular_coat_pigmentation1.08662734
51MP0005377_hearing/vestibular/ear_phenot1.07372316
52MP0003878_abnormal_ear_physiology1.07372316
53MP0003136_yellow_coat_color1.02376743
54MP0002148_abnormal_hypersensitivity_rea1.01394294
55MP0001800_abnormal_humoral_immune1.00457610
56MP0001929_abnormal_gametogenesis1.00426876
57MP0001486_abnormal_startle_reflex0.98941226
58MP0002751_abnormal_autonomic_nervous0.98230799
59MP0003011_delayed_dark_adaptation0.97924327
60MP0003195_calcinosis0.97539586
61MP0003806_abnormal_nucleotide_metabolis0.97326947
62MP0002736_abnormal_nociception_after0.95707762
63MP0005253_abnormal_eye_physiology0.92517831
64MP0009053_abnormal_anal_canal0.91773229
65MP0002163_abnormal_gland_morphology0.91430027
66MP0003890_abnormal_embryonic-extraembry0.91235676
67MP0009697_abnormal_copulation0.90919616
68MP0001501_abnormal_sleep_pattern0.87836883
69MP0001853_heart_inflammation0.87733920
70MP0003111_abnormal_nucleus_morphology0.86548950
71MP0002210_abnormal_sex_determination0.86432392
72MP0004142_abnormal_muscle_tone0.85682055
73MP0004147_increased_porphyrin_level0.85437152
74MP0003698_abnormal_male_reproductive0.81018689
75MP0004145_abnormal_muscle_electrophysio0.80992082
76MP0003763_abnormal_thymus_physiology0.78778734
77MP0003936_abnormal_reproductive_system0.76881536
78MP0008932_abnormal_embryonic_tissue0.76677901
79MP0001663_abnormal_digestive_system0.75453782
80MP0002234_abnormal_pharynx_morphology0.75009991
81MP0009745_abnormal_behavioral_response0.74982361
82MP0000026_abnormal_inner_ear0.74490540
83MP0006035_abnormal_mitochondrial_morpho0.74088860
84MP0009250_abnormal_appendicular_skeleto0.72669951
85MP0002095_abnormal_skin_pigmentation0.72640886
86MP0000703_abnormal_thymus_morphology0.72606666
87MP0001119_abnormal_female_reproductive0.72319063
88MP0005174_abnormal_tail_pigmentation0.71350564
89MP0002398_abnormal_bone_marrow0.70483522
90MP0005171_absent_coat_pigmentation0.70249598
91MP0003937_abnormal_limbs/digits/tail_de0.69907351
92MP0009785_altered_susceptibility_to0.68637765
93MP0000569_abnormal_digit_pigmentation0.68405532
94MP0002733_abnormal_thermal_nociception0.68317624
95MP0006292_abnormal_olfactory_placode0.67689611
96MP0002272_abnormal_nervous_system0.67532340
97MP0002184_abnormal_innervation0.66694754
98MP0000653_abnormal_sex_gland0.65831799
99MP0002693_abnormal_pancreas_physiology0.63535352
100MP0001145_abnormal_male_reproductive0.62143819

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.55355202
2Oligodactyly (hands) (HP:0001180)3.93364018
3Abnormality of the anterior horn cell (HP:0006802)3.58712715
4Degeneration of anterior horn cells (HP:0002398)3.58712715
5Urethral obstruction (HP:0000796)3.48439916
6Congenital stationary night blindness (HP:0007642)3.45145284
7Stomatitis (HP:0010280)3.18929500
8Hypoplastic pelvis (HP:0008839)3.09913770
9Increased hepatocellular lipid droplets (HP:0006565)3.05752286
10B lymphocytopenia (HP:0010976)3.05655970
11Aplasia/hypoplasia of the uterus (HP:0008684)3.03614680
12Acute necrotizing encephalopathy (HP:0006965)2.98161726
13Fibular aplasia (HP:0002990)2.96880597
14Acute encephalopathy (HP:0006846)2.91327832
15Mitochondrial inheritance (HP:0001427)2.85398260
16Increased CSF lactate (HP:0002490)2.82072797
17Pancreatic cysts (HP:0001737)2.79657092
18Abnormality of macular pigmentation (HP:0008002)2.79445456
19Abnormality of B cell number (HP:0010975)2.77566574
20Chronic bronchitis (HP:0004469)2.73665290
21Lipid accumulation in hepatocytes (HP:0006561)2.73583076
22Abnormal mitochondria in muscle tissue (HP:0008316)2.69737054
23Humeroradial synostosis (HP:0003041)2.67488450
24Synostosis involving the elbow (HP:0003938)2.67488450
25Abnormality of the pons (HP:0007361)2.63140539
26IgG deficiency (HP:0004315)2.60081108
27Hypoproteinemia (HP:0003075)2.55199606
28Adactyly (HP:0009776)2.53380515
29Split foot (HP:0001839)2.51749168
30Oligodactyly (HP:0012165)2.51016576
31Abnormal lung lobation (HP:0002101)2.49059761
32Progressive macrocephaly (HP:0004481)2.46778350
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41084753
34Thyroiditis (HP:0100646)2.38055841
35Renal Fanconi syndrome (HP:0001994)2.33889222
36Abnormality of midbrain morphology (HP:0002418)2.31050126
37Molar tooth sign on MRI (HP:0002419)2.31050126
38Abnormality of alanine metabolism (HP:0010916)2.29376430
39Hyperalaninemia (HP:0003348)2.29376430
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29376430
41Increased serum lactate (HP:0002151)2.26857816
42Hepatocellular necrosis (HP:0001404)2.24223395
43Chronic hepatic failure (HP:0100626)2.17442624
44Exertional dyspnea (HP:0002875)2.16633323
45Severe combined immunodeficiency (HP:0004430)2.16223087
46Hypoplasia of the pons (HP:0012110)2.16040222
47Abnormality of T cell physiology (HP:0011840)2.12891441
48Increased IgM level (HP:0003496)2.12518888
49Aplastic anemia (HP:0001915)2.10583554
50Colon cancer (HP:0003003)2.09571047
51Increased serum pyruvate (HP:0003542)2.08182748
52Abnormality of the labia minora (HP:0012880)2.08006485
53Abnormality of T cells (HP:0002843)2.06385846
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.01346346
55Meckel diverticulum (HP:0002245)2.00908976
56Abnormal finger flexion creases (HP:0006143)2.00865913
57Methylmalonic acidemia (HP:0002912)2.00338550
58Abnormality of the ileum (HP:0001549)2.00281323
59IgM deficiency (HP:0002850)2.00214641
60Hepatic necrosis (HP:0002605)1.95332827
61Intestinal atresia (HP:0011100)1.94954464
62Hyperglycinemia (HP:0002154)1.94803934
63Symphalangism affecting the phalanges of the hand (HP:0009773)1.94573643
64Hydroureter (HP:0000072)1.94069677
65Type I transferrin isoform profile (HP:0003642)1.93205866
66Nephronophthisis (HP:0000090)1.92906161
67IgA deficiency (HP:0002720)1.91970834
68Supernumerary spleens (HP:0009799)1.91132751
69Duodenal stenosis (HP:0100867)1.87909588
70Small intestinal stenosis (HP:0012848)1.87909588
71Rhinitis (HP:0012384)1.87768863
72Optic disc pallor (HP:0000543)1.85405955
73Patellar aplasia (HP:0006443)1.84862227
74Aplasia/Hypoplasia of the patella (HP:0006498)1.84834550
75Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83772156
76Limb hypertonia (HP:0002509)1.83302815
77Abnormality of glycolysis (HP:0004366)1.82702174
78Abnormality of serum amino acid levels (HP:0003112)1.82406880
79Hypoplasia of the fovea (HP:0007750)1.81948117
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.81948117
81Progressive inability to walk (HP:0002505)1.81738371
82Methylmalonic aciduria (HP:0012120)1.81688391
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81226287
84Abnormality of T cell number (HP:0011839)1.80904604
85Abnormality of the renal medulla (HP:0100957)1.79823083
86Aplasia/Hypoplasia of the ulna (HP:0006495)1.79148875
87Xerostomia (HP:0000217)1.78395642
88Pancreatic fibrosis (HP:0100732)1.77812814
89Cerebral edema (HP:0002181)1.75252441
90Lactic acidosis (HP:0003128)1.74505888
91Increased intramyocellular lipid droplets (HP:0012240)1.74434398
92Combined immunodeficiency (HP:0005387)1.73477157
93Panhypogammaglobulinemia (HP:0003139)1.72541733
94Inability to walk (HP:0002540)1.71842166
95T lymphocytopenia (HP:0005403)1.71573014
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70470550
97Abnormality of the duodenum (HP:0002246)1.70078237
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68824161
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.68824161
100Neuroendocrine neoplasm (HP:0100634)1.67270399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.00651314
2EIF2AK33.38181582
3MST43.34368703
4TAF13.13581063
5TXK3.11711523
6ADRBK23.10205197
7BUB12.92804709
8VRK22.81762342
9ZAK2.80778473
10TNIK2.57684727
11NUAK12.51573749
12NEK12.29071713
13PLK32.25021988
14VRK12.22380387
15PLK42.12476753
16TRIM281.87787811
17EIF2AK11.87779758
18PBK1.83830866
19MKNK21.73633322
20WNK41.72976592
21STK161.70802883
22TLK11.70638121
23SRPK11.69351430
24BMPR1B1.62816163
25STK391.44499182
26GRK11.42299306
27PINK11.37853712
28WNK31.34785318
29MKNK11.32464486
30BCR1.25683561
31PLK21.24517456
32MAP4K21.17446546
33PASK1.17341143
34NME11.17148398
35OXSR11.14263524
36STK38L1.12361204
37EIF2AK21.08220769
38TGFBR11.04461874
39CDC71.00190269
40TTK0.99550843
41DYRK30.98207885
42INSRR0.97947598
43PLK10.92255373
44CSNK1G20.90507722
45PIK3CG0.87278101
46CDK60.83069886
47IRAK20.82064343
48STK240.79095555
49WEE10.74531096
50DYRK20.73764601
51CSNK1G30.73121714
52FRK0.71565760
53BCKDK0.70840248
54RPS6KA40.70262246
55CSNK1G10.69252582
56CSNK1A1L0.68516690
57CCNB10.67948695
58ERBB30.67178418
59NEK90.66987691
60PRKCE0.66271056
61ITK0.64323837
62TEC0.59662024
63TIE10.57199059
64AKT30.56504561
65PRKCG0.54873680
66CLK10.54429534
67FGFR10.53621375
68ALK0.52309999
69ADRBK10.52243191
70ATR0.51469473
71AURKB0.50526743
72PNCK0.50444068
73GRK50.49664653
74STK30.48863962
75IKBKB0.48244174
76CDK70.47449127
77CSNK2A20.45907757
78MAP2K60.44641855
79BRSK20.43127610
80BRD40.41152826
81CDK30.38430318
82ACVR1B0.37255137
83PRKCQ0.36525197
84MAPKAPK50.36261955
85IRAK10.35957288
86CSNK2A10.35903123
87TAOK30.34896417
88RPS6KA50.34081677
89CAMK2A0.33989067
90ATM0.32041081
91CSNK1E0.31416499
92PRKCB0.30450343
93CSNK1A10.29796574
94NEK60.27157596
95NME20.26342401
96KIT0.25730318
97MAP3K40.25185226
98CHEK20.25027357
99MAP4K10.24279350
100PRKCI0.22650419

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.69766208
2Protein export_Homo sapiens_hsa030604.29056222
3Basal transcription factors_Homo sapiens_hsa030223.37698376
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90193839
5RNA polymerase_Homo sapiens_hsa030202.64673836
6Ribosome_Homo sapiens_hsa030102.59539411
7Asthma_Homo sapiens_hsa053102.41565415
8Parkinsons disease_Homo sapiens_hsa050122.29214239
9Non-homologous end-joining_Homo sapiens_hsa034502.28065503
10Oxidative phosphorylation_Homo sapiens_hsa001902.27687779
11RNA transport_Homo sapiens_hsa030132.17998819
12Mismatch repair_Homo sapiens_hsa034302.01078964
13Autoimmune thyroid disease_Homo sapiens_hsa053201.97498014
14Allograft rejection_Homo sapiens_hsa053301.93260097
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75269447
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.73415770
17Nucleotide excision repair_Homo sapiens_hsa034201.72017477
18Propanoate metabolism_Homo sapiens_hsa006401.69795847
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69316294
20DNA replication_Homo sapiens_hsa030301.68387632
21Primary immunodeficiency_Homo sapiens_hsa053401.67333454
22One carbon pool by folate_Homo sapiens_hsa006701.61231853
23RNA degradation_Homo sapiens_hsa030181.58019789
24Vitamin B6 metabolism_Homo sapiens_hsa007501.49323259
25Homologous recombination_Homo sapiens_hsa034401.49233359
26Huntingtons disease_Homo sapiens_hsa050161.45321096
27Spliceosome_Homo sapiens_hsa030401.43615219
28Fanconi anemia pathway_Homo sapiens_hsa034601.43436931
29Phototransduction_Homo sapiens_hsa047441.39707168
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34318767
31Type I diabetes mellitus_Homo sapiens_hsa049401.28237291
32Graft-versus-host disease_Homo sapiens_hsa053321.24956086
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.24855414
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22646360
35Alzheimers disease_Homo sapiens_hsa050101.17666892
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17449238
37Pyrimidine metabolism_Homo sapiens_hsa002401.13713395
38Base excision repair_Homo sapiens_hsa034101.05083905
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04125552
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02216648
41Purine metabolism_Homo sapiens_hsa002301.00293807
42Nicotine addiction_Homo sapiens_hsa050330.95376108
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93921894
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90324035
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87797361
46Antigen processing and presentation_Homo sapiens_hsa046120.87486843
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85113886
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83719985
49Rheumatoid arthritis_Homo sapiens_hsa053230.81329949
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78299470
51Linoleic acid metabolism_Homo sapiens_hsa005910.77865104
52Olfactory transduction_Homo sapiens_hsa047400.75355743
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.75176453
54Cardiac muscle contraction_Homo sapiens_hsa042600.74612783
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73936153
56Cell cycle_Homo sapiens_hsa041100.73649254
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72902491
58Hematopoietic cell lineage_Homo sapiens_hsa046400.68279336
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67236225
60Steroid biosynthesis_Homo sapiens_hsa001000.66331885
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65666621
62Taste transduction_Homo sapiens_hsa047420.65305138
63Tryptophan metabolism_Homo sapiens_hsa003800.64839938
64Caffeine metabolism_Homo sapiens_hsa002320.64816528
65Sulfur metabolism_Homo sapiens_hsa009200.64633962
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63244096
67Pyruvate metabolism_Homo sapiens_hsa006200.62185304
68Nitrogen metabolism_Homo sapiens_hsa009100.60237870
69Morphine addiction_Homo sapiens_hsa050320.59325864
70Peroxisome_Homo sapiens_hsa041460.58973099
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.58667646
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57777303
73Epstein-Barr virus infection_Homo sapiens_hsa051690.55500313
74Glutathione metabolism_Homo sapiens_hsa004800.54912699
75T cell receptor signaling pathway_Homo sapiens_hsa046600.52634154
76Regulation of autophagy_Homo sapiens_hsa041400.50728259
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.50421580
78mRNA surveillance pathway_Homo sapiens_hsa030150.47906117
79beta-Alanine metabolism_Homo sapiens_hsa004100.46526386
80p53 signaling pathway_Homo sapiens_hsa041150.45978994
81Metabolic pathways_Homo sapiens_hsa011000.42773526
82Systemic lupus erythematosus_Homo sapiens_hsa053220.40979990
83Retinol metabolism_Homo sapiens_hsa008300.40594931
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38662837
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38528958
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35686677
87Measles_Homo sapiens_hsa051620.34861096
88Selenocompound metabolism_Homo sapiens_hsa004500.33163022
89TGF-beta signaling pathway_Homo sapiens_hsa043500.31615760
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30603124
91Fat digestion and absorption_Homo sapiens_hsa049750.30269881
92Collecting duct acid secretion_Homo sapiens_hsa049660.28952762
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.28681383
94Oocyte meiosis_Homo sapiens_hsa041140.25617754
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.24567001
96Cocaine addiction_Homo sapiens_hsa050300.24565823
97Folate biosynthesis_Homo sapiens_hsa007900.24144102
98Butanoate metabolism_Homo sapiens_hsa006500.23455761
99Sulfur relay system_Homo sapiens_hsa041220.22724722
100Carbon metabolism_Homo sapiens_hsa012000.22650766

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