

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.93174275 |
| 2 | rRNA methylation (GO:0031167) | 5.78248818 |
| 3 | rRNA modification (GO:0000154) | 5.73534553 |
| 4 | DNA deamination (GO:0045006) | 5.25168931 |
| 5 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.48389589 |
| 6 | cullin deneddylation (GO:0010388) | 4.14230460 |
| 7 | protein-cofactor linkage (GO:0018065) | 4.08781054 |
| 8 | maturation of 5.8S rRNA (GO:0000460) | 4.02681010 |
| 9 | signal peptide processing (GO:0006465) | 3.97088942 |
| 10 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.92289928 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 3.85560224 |
| 12 | protein deneddylation (GO:0000338) | 3.82467180 |
| 13 | protein neddylation (GO:0045116) | 3.78493241 |
| 14 | dopamine transport (GO:0015872) | 3.68882275 |
| 15 | termination of RNA polymerase I transcription (GO:0006363) | 3.66893319 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.55919213 |
| 17 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.54882157 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.47247443 |
| 19 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.46312452 |
| 20 | respiratory chain complex IV assembly (GO:0008535) | 3.43858981 |
| 21 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.40380706 |
| 22 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.37087324 |
| 23 | ribosome assembly (GO:0042255) | 3.35060946 |
| 24 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.34842799 |
| 25 | regulation of chronic inflammatory response (GO:0002676) | 3.30288483 |
| 26 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.28246873 |
| 27 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.25967145 |
| 28 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.23310993 |
| 29 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.23310993 |
| 30 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.23310993 |
| 31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.23066561 |
| 32 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.22759028 |
| 33 | DNA double-strand break processing (GO:0000729) | 3.22320810 |
| 34 | ribosomal large subunit biogenesis (GO:0042273) | 3.22142951 |
| 35 | chromatin remodeling at centromere (GO:0031055) | 3.20548738 |
| 36 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.20480691 |
| 37 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.20480691 |
| 38 | isotype switching (GO:0045190) | 3.20480691 |
| 39 | negative regulation of cAMP-mediated signaling (GO:0043951) | 3.19668480 |
| 40 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.18500524 |
| 41 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.18399238 |
| 42 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.15342990 |
| 43 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.15342990 |
| 44 | DNA damage response, detection of DNA damage (GO:0042769) | 3.14698667 |
| 45 | CENP-A containing nucleosome assembly (GO:0034080) | 3.11291384 |
| 46 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.10164608 |
| 47 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.09897154 |
| 48 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.08213413 |
| 49 | termination of RNA polymerase III transcription (GO:0006386) | 3.08213413 |
| 50 | histone mRNA metabolic process (GO:0008334) | 3.08172092 |
| 51 | regulation of immunoglobulin secretion (GO:0051023) | 3.08146159 |
| 52 | protein complex biogenesis (GO:0070271) | 3.07676691 |
| 53 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.07398765 |
| 54 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.05731013 |
| 55 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.03243968 |
| 56 | ATP synthesis coupled proton transport (GO:0015986) | 3.03243968 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.02897553 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.02897553 |
| 59 | cytidine deamination (GO:0009972) | 3.01131316 |
| 60 | cytidine metabolic process (GO:0046087) | 3.01131316 |
| 61 | cytidine catabolic process (GO:0006216) | 3.01131316 |
| 62 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.00815302 |
| 63 | formation of translation preinitiation complex (GO:0001731) | 2.99889982 |
| 64 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.99282776 |
| 65 | negative regulation of ligase activity (GO:0051352) | 2.99282776 |
| 66 | auditory receptor cell stereocilium organization (GO:0060088) | 2.98083968 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.97634575 |
| 68 | peristalsis (GO:0030432) | 2.95984440 |
| 69 | protein targeting to mitochondrion (GO:0006626) | 2.94722364 |
| 70 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 2.93894118 |
| 71 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 2.93894118 |
| 72 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.91449609 |
| 73 | rRNA processing (GO:0006364) | 2.85108960 |
| 74 | transcription from RNA polymerase I promoter (GO:0006360) | 2.82484549 |
| 75 | protein localization to mitochondrion (GO:0070585) | 2.79619870 |
| 76 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.79109814 |
| 77 | DNA replication checkpoint (GO:0000076) | 2.78904976 |
| 78 | 7-methylguanosine mRNA capping (GO:0006370) | 2.78372985 |
| 79 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.77118743 |
| 80 | histone exchange (GO:0043486) | 2.77101065 |
| 81 | response to pheromone (GO:0019236) | 2.75602506 |
| 82 | replication fork processing (GO:0031297) | 2.74915794 |
| 83 | rRNA metabolic process (GO:0016072) | 2.73845388 |
| 84 | cytochrome complex assembly (GO:0017004) | 2.72801910 |
| 85 | RNA capping (GO:0036260) | 2.71877493 |
| 86 | 7-methylguanosine RNA capping (GO:0009452) | 2.71877493 |
| 87 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.70569880 |
| 88 | centriole replication (GO:0007099) | 2.69506242 |
| 89 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.68435539 |
| 90 | establishment of protein localization to mitochondrion (GO:0072655) | 2.67095703 |
| 91 | positive regulation of ligase activity (GO:0051351) | 2.65745763 |
| 92 | regulation of regulatory T cell differentiation (GO:0045589) | 2.63816324 |
| 93 | spliceosomal snRNP assembly (GO:0000387) | 2.63632584 |
| 94 | translation (GO:0006412) | 2.62355794 |
| 95 | sulfation (GO:0051923) | 2.62130560 |
| 96 | pseudouridine synthesis (GO:0001522) | 2.60478536 |
| 97 | ribosomal small subunit assembly (GO:0000028) | 2.59743599 |
| 98 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.58260903 |
| 99 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.58260903 |
| 100 | NADH dehydrogenase complex assembly (GO:0010257) | 2.58260903 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.98397737 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.30894402 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.00742242 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.62785402 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.40421692 |
| 6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.01839506 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.87636642 |
| 8 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.74475387 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.67461402 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.67199856 |
| 11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.57694716 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.47762853 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.42635998 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.40907164 |
| 15 | EWS_26573619_Chip-Seq_HEK293_Human | 2.31969933 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.31962103 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.29943271 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 2.27650047 |
| 19 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.13956599 |
| 20 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.11571520 |
| 21 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.09974491 |
| 22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.09543800 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.01187059 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.97914241 |
| 25 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.92562210 |
| 26 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.75557171 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.74381387 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.71248393 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.62945807 |
| 30 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.58661289 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.58447663 |
| 32 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.56822728 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53362065 |
| 34 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.53130267 |
| 35 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.51045461 |
| 36 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.48820335 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.48436954 |
| 38 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.46060402 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.45835253 |
| 40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.42646507 |
| 41 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.36032341 |
| 42 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.35783798 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.35428736 |
| 44 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.34060106 |
| 45 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.32703800 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.31131369 |
| 47 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.29710186 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.29518476 |
| 49 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.28712340 |
| 50 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.26825228 |
| 51 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.25896888 |
| 52 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.23694675 |
| 53 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.23452783 |
| 54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.22844210 |
| 55 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.21504559 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.20309352 |
| 57 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.19774385 |
| 58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.17086351 |
| 59 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.17026573 |
| 60 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.16927760 |
| 61 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.13753879 |
| 62 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.13627678 |
| 63 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.12186437 |
| 64 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.12186437 |
| 65 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.09890580 |
| 66 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.08491550 |
| 67 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.08409321 |
| 68 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.08409321 |
| 69 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06519561 |
| 70 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.06362751 |
| 71 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.05340976 |
| 72 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.04846848 |
| 73 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.03767620 |
| 74 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.03731004 |
| 75 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.01754474 |
| 76 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.01668325 |
| 77 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.01585647 |
| 78 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.99827955 |
| 79 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.99321061 |
| 80 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99138219 |
| 81 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.97598242 |
| 82 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.97477616 |
| 83 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95568790 |
| 84 | GATA3_26560356_Chip-Seq_TH2_Human | 0.95303197 |
| 85 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.94346568 |
| 86 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.93282710 |
| 87 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93224874 |
| 88 | JUN_21703547_ChIP-Seq_K562_Human | 0.92137009 |
| 89 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.91604916 |
| 90 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.90380056 |
| 91 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.90275392 |
| 92 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.89890905 |
| 93 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.89890905 |
| 94 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.88640003 |
| 95 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.87768424 |
| 96 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.87768046 |
| 97 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.86985387 |
| 98 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.86220431 |
| 99 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.84834646 |
| 100 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.84732743 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 5.02804837 |
| 2 | MP0003880_abnormal_central_pattern | 4.96850977 |
| 3 | MP0008058_abnormal_DNA_repair | 3.20571447 |
| 4 | MP0002138_abnormal_hepatobiliary_system | 3.01186373 |
| 5 | MP0003693_abnormal_embryo_hatching | 2.76775863 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 2.72118433 |
| 7 | MP0002102_abnormal_ear_morphology | 2.57607720 |
| 8 | MP0001873_stomach_inflammation | 2.54577829 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.49855070 |
| 10 | MP0010386_abnormal_urinary_bladder | 2.29752165 |
| 11 | MP0001835_abnormal_antigen_presentation | 2.12752615 |
| 12 | MP0005084_abnormal_gallbladder_morpholo | 2.03566924 |
| 13 | MP0005310_abnormal_salivary_gland | 2.02148395 |
| 14 | MP0002876_abnormal_thyroid_physiology | 1.89466894 |
| 15 | MP0001529_abnormal_vocalization | 1.81868022 |
| 16 | MP0000685_abnormal_immune_system | 1.80835118 |
| 17 | MP0003718_maternal_effect | 1.80405802 |
| 18 | MP0001348_abnormal_lacrimal_gland | 1.66813988 |
| 19 | MP0005085_abnormal_gallbladder_physiolo | 1.66500357 |
| 20 | MP0005671_abnormal_response_to | 1.65778601 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.65486915 |
| 22 | MP0008872_abnormal_physiological_respon | 1.62851605 |
| 23 | MP0001485_abnormal_pinna_reflex | 1.61084660 |
| 24 | MP0005410_abnormal_fertilization | 1.59993153 |
| 25 | MP0005387_immune_system_phenotype | 1.57316362 |
| 26 | MP0001790_abnormal_immune_system | 1.57316362 |
| 27 | MP0003077_abnormal_cell_cycle | 1.57059410 |
| 28 | MP0002277_abnormal_respiratory_mucosa | 1.55987049 |
| 29 | MP0005408_hypopigmentation | 1.54122705 |
| 30 | MP0008875_abnormal_xenobiotic_pharmacok | 1.53176262 |
| 31 | MP0001293_anophthalmia | 1.47532457 |
| 32 | MP0008877_abnormal_DNA_methylation | 1.45191707 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.41983224 |
| 34 | MP0006072_abnormal_retinal_apoptosis | 1.41763347 |
| 35 | MP0005379_endocrine/exocrine_gland_phen | 1.39156766 |
| 36 | MP0009333_abnormal_splenocyte_physiolog | 1.38648949 |
| 37 | MP0001984_abnormal_olfaction | 1.36160025 |
| 38 | MP0003252_abnormal_bile_duct | 1.32861420 |
| 39 | MP0004885_abnormal_endolymph | 1.28511348 |
| 40 | MP0005551_abnormal_eye_electrophysiolog | 1.27901959 |
| 41 | MP0005075_abnormal_melanosome_morpholog | 1.25322433 |
| 42 | MP0002006_tumorigenesis | 1.24091693 |
| 43 | MP0001764_abnormal_homeostasis | 1.23902614 |
| 44 | MP0008007_abnormal_cellular_replicative | 1.22889185 |
| 45 | MP0004215_abnormal_myocardial_fiber | 1.22436685 |
| 46 | MP0003119_abnormal_digestive_system | 1.18010979 |
| 47 | MP0003786_premature_aging | 1.18010957 |
| 48 | MP0006036_abnormal_mitochondrial_physio | 1.12630940 |
| 49 | MP0002928_abnormal_bile_duct | 1.09990764 |
| 50 | MP0000372_irregular_coat_pigmentation | 1.08662734 |
| 51 | MP0005377_hearing/vestibular/ear_phenot | 1.07372316 |
| 52 | MP0003878_abnormal_ear_physiology | 1.07372316 |
| 53 | MP0003136_yellow_coat_color | 1.02376743 |
| 54 | MP0002148_abnormal_hypersensitivity_rea | 1.01394294 |
| 55 | MP0001800_abnormal_humoral_immune | 1.00457610 |
| 56 | MP0001929_abnormal_gametogenesis | 1.00426876 |
| 57 | MP0001486_abnormal_startle_reflex | 0.98941226 |
| 58 | MP0002751_abnormal_autonomic_nervous | 0.98230799 |
| 59 | MP0003011_delayed_dark_adaptation | 0.97924327 |
| 60 | MP0003195_calcinosis | 0.97539586 |
| 61 | MP0003806_abnormal_nucleotide_metabolis | 0.97326947 |
| 62 | MP0002736_abnormal_nociception_after | 0.95707762 |
| 63 | MP0005253_abnormal_eye_physiology | 0.92517831 |
| 64 | MP0009053_abnormal_anal_canal | 0.91773229 |
| 65 | MP0002163_abnormal_gland_morphology | 0.91430027 |
| 66 | MP0003890_abnormal_embryonic-extraembry | 0.91235676 |
| 67 | MP0009697_abnormal_copulation | 0.90919616 |
| 68 | MP0001501_abnormal_sleep_pattern | 0.87836883 |
| 69 | MP0001853_heart_inflammation | 0.87733920 |
| 70 | MP0003111_abnormal_nucleus_morphology | 0.86548950 |
| 71 | MP0002210_abnormal_sex_determination | 0.86432392 |
| 72 | MP0004142_abnormal_muscle_tone | 0.85682055 |
| 73 | MP0004147_increased_porphyrin_level | 0.85437152 |
| 74 | MP0003698_abnormal_male_reproductive | 0.81018689 |
| 75 | MP0004145_abnormal_muscle_electrophysio | 0.80992082 |
| 76 | MP0003763_abnormal_thymus_physiology | 0.78778734 |
| 77 | MP0003936_abnormal_reproductive_system | 0.76881536 |
| 78 | MP0008932_abnormal_embryonic_tissue | 0.76677901 |
| 79 | MP0001663_abnormal_digestive_system | 0.75453782 |
| 80 | MP0002234_abnormal_pharynx_morphology | 0.75009991 |
| 81 | MP0009745_abnormal_behavioral_response | 0.74982361 |
| 82 | MP0000026_abnormal_inner_ear | 0.74490540 |
| 83 | MP0006035_abnormal_mitochondrial_morpho | 0.74088860 |
| 84 | MP0009250_abnormal_appendicular_skeleto | 0.72669951 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.72640886 |
| 86 | MP0000703_abnormal_thymus_morphology | 0.72606666 |
| 87 | MP0001119_abnormal_female_reproductive | 0.72319063 |
| 88 | MP0005174_abnormal_tail_pigmentation | 0.71350564 |
| 89 | MP0002398_abnormal_bone_marrow | 0.70483522 |
| 90 | MP0005171_absent_coat_pigmentation | 0.70249598 |
| 91 | MP0003937_abnormal_limbs/digits/tail_de | 0.69907351 |
| 92 | MP0009785_altered_susceptibility_to | 0.68637765 |
| 93 | MP0000569_abnormal_digit_pigmentation | 0.68405532 |
| 94 | MP0002733_abnormal_thermal_nociception | 0.68317624 |
| 95 | MP0006292_abnormal_olfactory_placode | 0.67689611 |
| 96 | MP0002272_abnormal_nervous_system | 0.67532340 |
| 97 | MP0002184_abnormal_innervation | 0.66694754 |
| 98 | MP0000653_abnormal_sex_gland | 0.65831799 |
| 99 | MP0002693_abnormal_pancreas_physiology | 0.63535352 |
| 100 | MP0001145_abnormal_male_reproductive | 0.62143819 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 4.55355202 |
| 2 | Oligodactyly (hands) (HP:0001180) | 3.93364018 |
| 3 | Abnormality of the anterior horn cell (HP:0006802) | 3.58712715 |
| 4 | Degeneration of anterior horn cells (HP:0002398) | 3.58712715 |
| 5 | Urethral obstruction (HP:0000796) | 3.48439916 |
| 6 | Congenital stationary night blindness (HP:0007642) | 3.45145284 |
| 7 | Stomatitis (HP:0010280) | 3.18929500 |
| 8 | Hypoplastic pelvis (HP:0008839) | 3.09913770 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.05752286 |
| 10 | B lymphocytopenia (HP:0010976) | 3.05655970 |
| 11 | Aplasia/hypoplasia of the uterus (HP:0008684) | 3.03614680 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 2.98161726 |
| 13 | Fibular aplasia (HP:0002990) | 2.96880597 |
| 14 | Acute encephalopathy (HP:0006846) | 2.91327832 |
| 15 | Mitochondrial inheritance (HP:0001427) | 2.85398260 |
| 16 | Increased CSF lactate (HP:0002490) | 2.82072797 |
| 17 | Pancreatic cysts (HP:0001737) | 2.79657092 |
| 18 | Abnormality of macular pigmentation (HP:0008002) | 2.79445456 |
| 19 | Abnormality of B cell number (HP:0010975) | 2.77566574 |
| 20 | Chronic bronchitis (HP:0004469) | 2.73665290 |
| 21 | Lipid accumulation in hepatocytes (HP:0006561) | 2.73583076 |
| 22 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.69737054 |
| 23 | Humeroradial synostosis (HP:0003041) | 2.67488450 |
| 24 | Synostosis involving the elbow (HP:0003938) | 2.67488450 |
| 25 | Abnormality of the pons (HP:0007361) | 2.63140539 |
| 26 | IgG deficiency (HP:0004315) | 2.60081108 |
| 27 | Hypoproteinemia (HP:0003075) | 2.55199606 |
| 28 | Adactyly (HP:0009776) | 2.53380515 |
| 29 | Split foot (HP:0001839) | 2.51749168 |
| 30 | Oligodactyly (HP:0012165) | 2.51016576 |
| 31 | Abnormal lung lobation (HP:0002101) | 2.49059761 |
| 32 | Progressive macrocephaly (HP:0004481) | 2.46778350 |
| 33 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.41084753 |
| 34 | Thyroiditis (HP:0100646) | 2.38055841 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.33889222 |
| 36 | Abnormality of midbrain morphology (HP:0002418) | 2.31050126 |
| 37 | Molar tooth sign on MRI (HP:0002419) | 2.31050126 |
| 38 | Abnormality of alanine metabolism (HP:0010916) | 2.29376430 |
| 39 | Hyperalaninemia (HP:0003348) | 2.29376430 |
| 40 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.29376430 |
| 41 | Increased serum lactate (HP:0002151) | 2.26857816 |
| 42 | Hepatocellular necrosis (HP:0001404) | 2.24223395 |
| 43 | Chronic hepatic failure (HP:0100626) | 2.17442624 |
| 44 | Exertional dyspnea (HP:0002875) | 2.16633323 |
| 45 | Severe combined immunodeficiency (HP:0004430) | 2.16223087 |
| 46 | Hypoplasia of the pons (HP:0012110) | 2.16040222 |
| 47 | Abnormality of T cell physiology (HP:0011840) | 2.12891441 |
| 48 | Increased IgM level (HP:0003496) | 2.12518888 |
| 49 | Aplastic anemia (HP:0001915) | 2.10583554 |
| 50 | Colon cancer (HP:0003003) | 2.09571047 |
| 51 | Increased serum pyruvate (HP:0003542) | 2.08182748 |
| 52 | Abnormality of the labia minora (HP:0012880) | 2.08006485 |
| 53 | Abnormality of T cells (HP:0002843) | 2.06385846 |
| 54 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.01346346 |
| 55 | Meckel diverticulum (HP:0002245) | 2.00908976 |
| 56 | Abnormal finger flexion creases (HP:0006143) | 2.00865913 |
| 57 | Methylmalonic acidemia (HP:0002912) | 2.00338550 |
| 58 | Abnormality of the ileum (HP:0001549) | 2.00281323 |
| 59 | IgM deficiency (HP:0002850) | 2.00214641 |
| 60 | Hepatic necrosis (HP:0002605) | 1.95332827 |
| 61 | Intestinal atresia (HP:0011100) | 1.94954464 |
| 62 | Hyperglycinemia (HP:0002154) | 1.94803934 |
| 63 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.94573643 |
| 64 | Hydroureter (HP:0000072) | 1.94069677 |
| 65 | Type I transferrin isoform profile (HP:0003642) | 1.93205866 |
| 66 | Nephronophthisis (HP:0000090) | 1.92906161 |
| 67 | IgA deficiency (HP:0002720) | 1.91970834 |
| 68 | Supernumerary spleens (HP:0009799) | 1.91132751 |
| 69 | Duodenal stenosis (HP:0100867) | 1.87909588 |
| 70 | Small intestinal stenosis (HP:0012848) | 1.87909588 |
| 71 | Rhinitis (HP:0012384) | 1.87768863 |
| 72 | Optic disc pallor (HP:0000543) | 1.85405955 |
| 73 | Patellar aplasia (HP:0006443) | 1.84862227 |
| 74 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.84834550 |
| 75 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.83772156 |
| 76 | Limb hypertonia (HP:0002509) | 1.83302815 |
| 77 | Abnormality of glycolysis (HP:0004366) | 1.82702174 |
| 78 | Abnormality of serum amino acid levels (HP:0003112) | 1.82406880 |
| 79 | Hypoplasia of the fovea (HP:0007750) | 1.81948117 |
| 80 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.81948117 |
| 81 | Progressive inability to walk (HP:0002505) | 1.81738371 |
| 82 | Methylmalonic aciduria (HP:0012120) | 1.81688391 |
| 83 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.81226287 |
| 84 | Abnormality of T cell number (HP:0011839) | 1.80904604 |
| 85 | Abnormality of the renal medulla (HP:0100957) | 1.79823083 |
| 86 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.79148875 |
| 87 | Xerostomia (HP:0000217) | 1.78395642 |
| 88 | Pancreatic fibrosis (HP:0100732) | 1.77812814 |
| 89 | Cerebral edema (HP:0002181) | 1.75252441 |
| 90 | Lactic acidosis (HP:0003128) | 1.74505888 |
| 91 | Increased intramyocellular lipid droplets (HP:0012240) | 1.74434398 |
| 92 | Combined immunodeficiency (HP:0005387) | 1.73477157 |
| 93 | Panhypogammaglobulinemia (HP:0003139) | 1.72541733 |
| 94 | Inability to walk (HP:0002540) | 1.71842166 |
| 95 | T lymphocytopenia (HP:0005403) | 1.71573014 |
| 96 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.70470550 |
| 97 | Abnormality of the duodenum (HP:0002246) | 1.70078237 |
| 98 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.68824161 |
| 99 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.68824161 |
| 100 | Neuroendocrine neoplasm (HP:0100634) | 1.67270399 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 4.00651314 |
| 2 | EIF2AK3 | 3.38181582 |
| 3 | MST4 | 3.34368703 |
| 4 | TAF1 | 3.13581063 |
| 5 | TXK | 3.11711523 |
| 6 | ADRBK2 | 3.10205197 |
| 7 | BUB1 | 2.92804709 |
| 8 | VRK2 | 2.81762342 |
| 9 | ZAK | 2.80778473 |
| 10 | TNIK | 2.57684727 |
| 11 | NUAK1 | 2.51573749 |
| 12 | NEK1 | 2.29071713 |
| 13 | PLK3 | 2.25021988 |
| 14 | VRK1 | 2.22380387 |
| 15 | PLK4 | 2.12476753 |
| 16 | TRIM28 | 1.87787811 |
| 17 | EIF2AK1 | 1.87779758 |
| 18 | PBK | 1.83830866 |
| 19 | MKNK2 | 1.73633322 |
| 20 | WNK4 | 1.72976592 |
| 21 | STK16 | 1.70802883 |
| 22 | TLK1 | 1.70638121 |
| 23 | SRPK1 | 1.69351430 |
| 24 | BMPR1B | 1.62816163 |
| 25 | STK39 | 1.44499182 |
| 26 | GRK1 | 1.42299306 |
| 27 | PINK1 | 1.37853712 |
| 28 | WNK3 | 1.34785318 |
| 29 | MKNK1 | 1.32464486 |
| 30 | BCR | 1.25683561 |
| 31 | PLK2 | 1.24517456 |
| 32 | MAP4K2 | 1.17446546 |
| 33 | PASK | 1.17341143 |
| 34 | NME1 | 1.17148398 |
| 35 | OXSR1 | 1.14263524 |
| 36 | STK38L | 1.12361204 |
| 37 | EIF2AK2 | 1.08220769 |
| 38 | TGFBR1 | 1.04461874 |
| 39 | CDC7 | 1.00190269 |
| 40 | TTK | 0.99550843 |
| 41 | DYRK3 | 0.98207885 |
| 42 | INSRR | 0.97947598 |
| 43 | PLK1 | 0.92255373 |
| 44 | CSNK1G2 | 0.90507722 |
| 45 | PIK3CG | 0.87278101 |
| 46 | CDK6 | 0.83069886 |
| 47 | IRAK2 | 0.82064343 |
| 48 | STK24 | 0.79095555 |
| 49 | WEE1 | 0.74531096 |
| 50 | DYRK2 | 0.73764601 |
| 51 | CSNK1G3 | 0.73121714 |
| 52 | FRK | 0.71565760 |
| 53 | BCKDK | 0.70840248 |
| 54 | RPS6KA4 | 0.70262246 |
| 55 | CSNK1G1 | 0.69252582 |
| 56 | CSNK1A1L | 0.68516690 |
| 57 | CCNB1 | 0.67948695 |
| 58 | ERBB3 | 0.67178418 |
| 59 | NEK9 | 0.66987691 |
| 60 | PRKCE | 0.66271056 |
| 61 | ITK | 0.64323837 |
| 62 | TEC | 0.59662024 |
| 63 | TIE1 | 0.57199059 |
| 64 | AKT3 | 0.56504561 |
| 65 | PRKCG | 0.54873680 |
| 66 | CLK1 | 0.54429534 |
| 67 | FGFR1 | 0.53621375 |
| 68 | ALK | 0.52309999 |
| 69 | ADRBK1 | 0.52243191 |
| 70 | ATR | 0.51469473 |
| 71 | AURKB | 0.50526743 |
| 72 | PNCK | 0.50444068 |
| 73 | GRK5 | 0.49664653 |
| 74 | STK3 | 0.48863962 |
| 75 | IKBKB | 0.48244174 |
| 76 | CDK7 | 0.47449127 |
| 77 | CSNK2A2 | 0.45907757 |
| 78 | MAP2K6 | 0.44641855 |
| 79 | BRSK2 | 0.43127610 |
| 80 | BRD4 | 0.41152826 |
| 81 | CDK3 | 0.38430318 |
| 82 | ACVR1B | 0.37255137 |
| 83 | PRKCQ | 0.36525197 |
| 84 | MAPKAPK5 | 0.36261955 |
| 85 | IRAK1 | 0.35957288 |
| 86 | CSNK2A1 | 0.35903123 |
| 87 | TAOK3 | 0.34896417 |
| 88 | RPS6KA5 | 0.34081677 |
| 89 | CAMK2A | 0.33989067 |
| 90 | ATM | 0.32041081 |
| 91 | CSNK1E | 0.31416499 |
| 92 | PRKCB | 0.30450343 |
| 93 | CSNK1A1 | 0.29796574 |
| 94 | NEK6 | 0.27157596 |
| 95 | NME2 | 0.26342401 |
| 96 | KIT | 0.25730318 |
| 97 | MAP3K4 | 0.25185226 |
| 98 | CHEK2 | 0.25027357 |
| 99 | MAP4K1 | 0.24279350 |
| 100 | PRKCI | 0.22650419 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.69766208 |
| 2 | Protein export_Homo sapiens_hsa03060 | 4.29056222 |
| 3 | Basal transcription factors_Homo sapiens_hsa03022 | 3.37698376 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.90193839 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.64673836 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.59539411 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.41565415 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.29214239 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.28065503 |
| 10 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.27687779 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.17998819 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.01078964 |
| 13 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.97498014 |
| 14 | Allograft rejection_Homo sapiens_hsa05330 | 1.93260097 |
| 15 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.75269447 |
| 16 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.73415770 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.72017477 |
| 18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.69795847 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.69316294 |
| 20 | DNA replication_Homo sapiens_hsa03030 | 1.68387632 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.67333454 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.61231853 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.58019789 |
| 24 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.49323259 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.49233359 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45321096 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.43615219 |
| 28 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.43436931 |
| 29 | Phototransduction_Homo sapiens_hsa04744 | 1.39707168 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.34318767 |
| 31 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.28237291 |
| 32 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.24956086 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.24855414 |
| 34 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.22646360 |
| 35 | Alzheimers disease_Homo sapiens_hsa05010 | 1.17666892 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.17449238 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.13713395 |
| 38 | Base excision repair_Homo sapiens_hsa03410 | 1.05083905 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.04125552 |
| 40 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.02216648 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 1.00293807 |
| 42 | Nicotine addiction_Homo sapiens_hsa05033 | 0.95376108 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.93921894 |
| 44 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.90324035 |
| 45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.87797361 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.87486843 |
| 47 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.85113886 |
| 48 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.83719985 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.81329949 |
| 50 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.78299470 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77865104 |
| 52 | Olfactory transduction_Homo sapiens_hsa04740 | 0.75355743 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.75176453 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74612783 |
| 55 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.73936153 |
| 56 | Cell cycle_Homo sapiens_hsa04110 | 0.73649254 |
| 57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.72902491 |
| 58 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.68279336 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67236225 |
| 60 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.66331885 |
| 61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65666621 |
| 62 | Taste transduction_Homo sapiens_hsa04742 | 0.65305138 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.64839938 |
| 64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.64816528 |
| 65 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64633962 |
| 66 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.63244096 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.62185304 |
| 68 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60237870 |
| 69 | Morphine addiction_Homo sapiens_hsa05032 | 0.59325864 |
| 70 | Peroxisome_Homo sapiens_hsa04146 | 0.58973099 |
| 71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.58667646 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.57777303 |
| 73 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.55500313 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54912699 |
| 75 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.52634154 |
| 76 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50728259 |
| 77 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.50421580 |
| 78 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.47906117 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46526386 |
| 80 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.45978994 |
| 81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.42773526 |
| 82 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.40979990 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.40594931 |
| 84 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.38662837 |
| 85 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.38528958 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35686677 |
| 87 | Measles_Homo sapiens_hsa05162 | 0.34861096 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.33163022 |
| 89 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.31615760 |
| 90 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.30603124 |
| 91 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.30269881 |
| 92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.28952762 |
| 93 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.28681383 |
| 94 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.25617754 |
| 95 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24567001 |
| 96 | Cocaine addiction_Homo sapiens_hsa05030 | 0.24565823 |
| 97 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24144102 |
| 98 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.23455761 |
| 99 | Sulfur relay system_Homo sapiens_hsa04122 | 0.22724722 |
| 100 | Carbon metabolism_Homo sapiens_hsa01200 | 0.22650766 |

